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Colin berry

Colin Berry, Kenneth Mangion, Faraz Pathan
No abstract text is available yet for this article.
October 2018: JACC. Cardiovascular Imaging
Thomas J Ford, Bethany Stanley, Richard Good, Paul Rocchiccioli, Margaret McEntegart, Stuart Watkins, Hany Eteiba, Aadil Shaukat, Mitchell Lindsay, Keith Robertson, Stuart Hood, Ross McGeoch, Robert McDade, Eric Yii, Novalia Sidik, Peter McCartney, David Corcoran, Damien Collison, Christopher Rush, Alex McConnachie, Rhian M Touyz, Keith G Oldroyd, Colin Berry
BACKGROUND: Angina without obstructive epicardial coronary artery disease (CAD) is a common problem with distinct underlying causes. OBJECTIVE: To test the hypothesis that stratified medical therapy guided by an interventional diagnostic procedure (IDP) improves patient outcomes. METHODS: We conducted a randomized, controlled, blinded clinical trial of stratified medical therapy versus standard care in patients with angina. We recruited patients with angina undergoing invasive coronary angiography (standard care)...
September 19, 2018: Journal of the American College of Cardiology
Valentina O Puntmann, Silvia Valbuena, Rocio Hinojar, Steffen E Petersen, John P Greenwood, Christopher M Kramer, Raymond Y Kwong, Gerry P McCann, Colin Berry, Eike Nagel
Cardiovascular disease remains a leading cause of morbidity and mortality globally. Changing natural history of the disease due to improved care of acute conditions and ageing population necessitates new strategies to tackle conditions which have more chronic and indolent course. These include an increased deployment of safe screening methods, life-long surveillance, and monitoring of both disease activity and tailored-treatment, by way of increasingly personalized medical care. Cardiovascular magnetic resonance (CMR) is a non-invasive, ionising radiation-free method, which can support a significant number of clinically relevant measurements and offers new opportunities to advance the state of art of diagnosis, prognosis and treatment...
September 20, 2018: Journal of Cardiovascular Magnetic Resonance
Yuhei Kobayashi, Jacob Lønborg, Andy Jong, Takeshi Nishi, Bernard De Bruyne, Dan Eik Høfsten, Henning Kelbæk, Jamie Layland, Chang-Wook Nam, Nico H J Pijls, Pim A L Tonino, Julie Warnøe, Keith G Oldroyd, Colin Berry, Thomas Engstrøm, William F Fearon
BACKGROUND: The residual SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) score (RSS) quantitatively assesses angiographic completeness of revascularization after percutaneous coronary intervention (PCI) and has been shown to be a predictor of events after angiography-guided PCI. In stable patients undergoing functionally complete revascularization with fractional flow reserve (FFR) guidance, RSS did not predict outcome. Whether this is also true in patients with acute coronary syndromes (ACS) is unknown...
September 18, 2018: Journal of the American College of Cardiology
Anoop S V Shah, Atul Anand, Fiona E Strachan, Amy V Ferry, Kuan Ken Lee, Andrew R Chapman, Dennis Sandeman, Catherine L Stables, Philip D Adamson, Jack P M Andrews, Mohamed S Anwar, John Hung, Alistair J Moss, Rachel O'Brien, Colin Berry, Iain Findlay, Simon Walker, Anne Cruickshank, Alan Reid, Alasdair Gray, Paul O Collinson, Fred S Apple, David A McAllister, Donogh Maguire, Keith A A Fox, David E Newby, Christopher Tuck, Ronald Harkess, Richard A Parker, Catriona Keerie, Christopher J Weir, Nicholas L Mills
BACKGROUND: High-sensitivity cardiac troponin assays permit use of lower thresholds for the diagnosis of myocardial infarction, but whether this improves clinical outcomes is unknown. We aimed to determine whether the introduction of a high-sensitivity cardiac troponin I (hs-cTnI) assay with a sex-specific 99th centile diagnostic threshold would reduce subsequent myocardial infarction or cardiovascular death in patients with suspected acute coronary syndrome. METHODS: In this stepped-wedge, cluster-randomised controlled trial across ten secondary or tertiary care hospitals in Scotland, we evaluated the implementation of an hs-cTnI assay in consecutive patients who had been admitted to the hospitals' emergency departments with suspected acute coronary syndrome...
September 15, 2018: Lancet
Thomas J Ford, Paul Rocchiccioli, Richard Good, Margaret McEntegart, Hany Eteiba, Stuart Watkins, Aadil Shaukat, Mitchell Lindsay, Keith Robertson, Stuart Hood, Eric Yii, Novalia Sidik, Adam Harvey, Augusto C Montezano, Elisabeth Beattie, Laura Haddow, Keith G Oldroyd, Rhian M Touyz, Colin Berry
Aims: Coronary microvascular dysfunction and/or vasospasm are potential causes of ischaemia in patients with no obstructive coronary artery disease (INOCA). We tested the hypothesis that these patients also have functional abnormalities in peripheral small arteries. Methods and results: Patients were prospectively enrolled and categorised as having microvascular angina (MVA), vasospastic angina (VSA) or normal control based on invasive coronary artery function tests incorporating probes of endothelial and endothelial-independent function (acetylcholine and adenosine)...
August 27, 2018: European Heart Journal
Colin Berry
Recent advances in our understanding of the process of carcinogenesis in Man have required revision of our thinking about the classical initiation/promotion sequence; understanding must now encompass the roles of both genetic and epigenetic change, realisation of the importance of the variable genetic backgrounds of the tumour bearers in any group and an understanding of the importance of random genetic events over time. The behavior of tumours, once established, is more complex than has been thought. Current views of the processes involved are not modelled in toxicity testing programmes...
July 1, 2018: Toxicology Research
Sonia V Shah, Frederik M Zimmermann, Nils P Johnson, Takeshi Nishi, Yuhei Kobayashi, Nils Witt, Colin Berry, Allen Jeremias, Bon-Kwon Koo, Giovanni Esposito, Gilles Rioufol, Seung-Jung Park, Keith G Oldroyd, Emanuele Barbato, Nico H J Pijls, Bernard De Bruyne, William F Fearon
OBJECTIVES: The goal of this study was to investigate sex differences in adenosine-free coronary pressure indexes. BACKGROUND: Several adenosine-free coronary pressure wire indexes have been proposed to assess the functional significance of coronary artery lesions; however, there is a theoretical concern that sex differences may affect diagnostic performance because of differences in resting flow and distal myocardial mass. METHODS: In this CONTRAST (Can Contrast Injection Better Approximate FFR Compared to Pure Resting Physiology?) substudy, contrast fractional flow reserve (cFFR), obtained during contrast-induced submaximal hyperemia, the instantaneous wave-free ratio (iFR), and distal/proximal coronary pressure ratio (Pd/Pa) were compared with fractional flow reserve (FFR) in 547 men and 216 women...
August 13, 2018: JACC. Cardiovascular Interventions
Caroline Haig, David Carrick, Jaclyn Carberry, Kenneth Mangion, Annette Maznyczka, Kirsty Wetherall, Margaret McEntegart, Mark C Petrie, Hany Eteiba, Mitchell Lindsay, Stuart Hood, Stuart Watkins, Andrew Davie, Ahmed Mahrous, Ify Mordi, Nadeem Ahmed, Vannesa Teng Yue May, Ian Ford, Aleksandra Radjenovic, Paul Welsh, Naveed Sattar, Keith G Oldroyd, Colin Berry
OBJECTIVES: The aim of this study was to mechanistically investigate associations among cigarette smoking, microvascular pathology, and longer term health outcomes in patients with acute ST-segment elevation myocardial infarction (MI). BACKGROUND: The pathophysiology of myocardial reperfusion injury and prognosis in smokers with acute ST-segment elevation MI is incompletely understood. METHODS: Patients were prospectively enrolled during emergency percutaneous coronary intervention...
July 13, 2018: JACC. Cardiovascular Imaging
Wardati Mazlan-Kepli, Jesse Dawson, Colin Berry, Matthew Walters
OBJECTIVE: To assess whether cardiovascular events are increased after cessation of dual antiplatelet therapy (DAPT) following acute coronary syndrome (ACS) and to explore predictors for recurrent events after DAPT cessation during long-term follow-up. METHODS: We did a retrospective observational cohort study. We included consecutive people with ACS who were discharged from Scottish hospitals between January 2008 and December 2013 and who received DAPT after discharge followed by antiplatelet monotherapy...
July 20, 2018: Heart: Official Journal of the British Cardiac Society
Michael Aschner, Herman Autrup, Colin L Berry, Alan R Boobis, Samuel M Cohen, Wolfgang Dekant, Corrado L Galli, Jay I Goodman, Gio B Gori, Helmut A Greim, Norbert E Kaminski, Curtis D Klaassen, James E Klaunig, Marcello Lotti, Hans Wj Marquardt, Angelo Moretto, Olavi Pelkonen, I Glenn Sipes, Kendall B Wallace, Hiroshi Yamazaki
Several recent and prominent articles in Science and Nature deliberately mischaracterized the nature of genuine scientific evidence. Those articles take issue with the United States Environmental Protection Agency's recent proposal to structure its policies and rules only from studies with transparently published raw data. The articles claim it is an effort to obfuscate with transparency, by eliminating a host of studies not offering raw data. A remarkable declaration by a Science editorial is that properly trained experts can verify the scientific evidence of studies without access to raw data, We assert the Agency's proposal must be sustained...
August 2018: Regulatory Toxicology and Pharmacology: RTP
David Carrick, Caroline Haig, Annette M Maznyczka, Jaclyn Carberry, Kenneth Mangion, Nadeem Ahmed, Vannesa Teng Yue May, Margaret McEntegart, Mark C Petrie, Hany Eteiba, Mitchell Lindsay, Stuart Hood, Stuart Watkins, Andrew Davie, Ahmed Mahrous, Ify Mordi, Ian Ford, Aleksandra Radjenovic, Paul Welsh, Naveed Sattar, Kirsty Wetherall, Keith G Oldroyd, Colin Berry
The rationale for our study was to investigate the pathophysiology of microvascular injury in patients with acute ST-segment-elevation myocardial infarction in relation to a history of hypertension. We undertook a cohort study using invasive and noninvasive measures of microvascular injury, cardiac magnetic resonance imaging at 2 days and 6 months, and assessed health outcomes in the longer term (URL: Unique identifier: NCT02072850). Three hundred twenty-four patients with acute myocardial infarction (mean age, 59 [12] years; blood pressure, 135 [25] / 79 [14] mm Hg; 237 [73%] male, 105 [32%] with antecedent hypertension) were prospectively enrolled during emergency percutaneous coronary intervention...
July 16, 2018: Hypertension
Junren Wang, Colin McGinty, Robert Reich, Valerie Finnemeyer, Harry Clark, Shaun Berry, Philip Bos
In this work, the detailed studies of surface polymerization stabilizing liquid crystal formed on an azodye sublayer are presented. The surface localized stabilization is obtained by free-radical polymerization of a dilute solution of a bi-functional reactive monomer (RM) in a liquid crystal (LC) solvent. To optimize the process for surface localized stabilization, we investigate the effects of several process parameters including RM concentration in LC hosts, the types of materials (either RM or LC), the photo-initiator (PI) concentration, ultra-violet (UV) polymerization intensity, and the UV curing temperature...
July 12, 2018: Materials
Colin Berry, Kenneth Mangion, David Corcoran
No abstract text is available yet for this article.
July 2018: JACC. Cardiovascular Imaging
Parastu Kasaie, Stephen A Berry, Maunank S Shah, Eli S Rosenberg, Karen W Hoover, Thomas L Gift, Harrell Chesson, Jeff Pennington, Danielle German, Colin P Flynn, Chris Beyrer, David W Dowdy
BACKGROUND: Pre-exposure prophylaxis (PrEP) greatly reduces the risk of HIV acquisition, but its optimal delivery strategy remains uncertain. Clinics for sexually transmitted infections (STIs) can provide an efficient venue for PrEP delivery. METHODS: To quantify the added value of STI clinic-based PrEP delivery, we used an agent-based simulation of HIV transmission among men who have sex with men (MSM). We simulated the impact of PrEP delivery through STI clinics compared with PrEP delivery in other community-based settings...
June 25, 2018: Sexually Transmitted Diseases
Martin J P Sullivan, Simon L Lewis, Wannes Hubau, Lan Qie, Timothy R Baker, Lindsay F Banin, Jerôme Chave, Aida Cuni-Sanchez, Ted R Feldpausch, Gabriela Lopez-Gonzalez, Eric Arets, Peter Ashton, Jean-François Bastin, Nicholas J Berry, Jan Bogaert, Rene Boot, Francis Q Brearley, Roel Brienen, David F R P Burslem, Charles de Canniere, Markéta Chudomelová, Martin Dančák, Corneille Ewango, Radim Hédl, Jon Lloyd, Jean-Remy Makana, Yadvinder Malhi, Beatriz S Marimon, Ben Hur Marimon Junior, Faizah Metali, Sam Moore, Laszlo Nagy, Percy Nuñez Vargas, Colin A Pendry, Hirma Ramírez-Angulo, Jan Reitsma, Ervan Rutishauser, Kamariah Abu Salim, Bonaventure Sonké, Rahayu S Sukri, Terry Sunderland, Martin Svátek, Peter M Umunay, Rodolfo Vasquez Martinez, Ronald R E Vernimmen, Emilio Vilanova Torre, Jason Vleminckx, Vincent Vos, Oliver L Phillips
Quantifying the relationship between tree diameter and height is a key component of efforts to estimate biomass and carbon stocks in tropical forests. Although substantial site-to-site variation in height-diameter allometries has been documented, the time consuming nature of measuring all tree heights in an inventory plot means that most studies do not include height, or else use generic pan-tropical or regional allometric equations to estimate height.Using a pan-tropical dataset of 73 plots where at least 150 trees had in-field ground-based height measurements, we examined how the number of trees sampled affects the performance of locally derived height-diameter allometries, and evaluated the performance of different methods for sampling trees for height measurement...
May 2018: Methods in Ecology and Evolution
Thomas J Ford, David Corcoran, Keith G Oldroyd, Margaret McEntegart, Paul Rocchiccioli, Stuart Watkins, Katriona Brooksbank, Sandosh Padmanabhan, Naveed Sattar, Andrew Briggs, Alex McConnachie, Rhian Touyz, Colin Berry
BACKGROUND: Coronary angiography is performed to assess for obstructive coronary artery disease (CAD), but "nonobstructive CAD" is a common finding. Microvascular or vasospastic angina may be relevant, but routine confirmatory testing is not evidence based and thus rarely performed. AIM: The aim was to assess the effect of stratified medicine guided by coronary function testing on the diagnosis, treatment, and well-being of patients with angina and nonobstructive CAD...
July 2018: American Heart Journal
Thomas J Ford, Peter McCartney, David Corcoran, Damien Collison, Barry Hennigan, Margaret McEntegart, David Hildick-Smith, Keith G Oldroyd, Colin Berry
BACKGROUND: The majority of coronary bifurcation lesions are treated with a provisional single-stent strategy rather than an up-front 2-stent strategy. This approach is supported by multiple randomized controlled clinical trials with short- to medium-term follow-up; however, long-term follow-up data is evolving from many data sets. METHODS AND RESULTS: Meta-analysis of randomized controlled trials evaluating long-term outcomes (≥1 year) according to treatment strategy for coronary bifurcation lesions...
May 25, 2018: Journal of the American Heart Association
Johan Svanerud, Jung-Min Ahn, Allen Jeremias, Marcel van 't Veer, Ankita Gore, Akiko Maehara, Aaron Crowley, Nico H J Pijls, Bernard De Bruyne, Nils P Johnson, Barry Hennigan, Stuart Watkins, Colin Berry, Keith G Oldroyd, Seung-Jung Park, Ziad A Ali
AIMS: Randomised controlled trials have reported instantaneous wave-free ratio (iFR) to be non-inferior to fractional flow reserve (FFR) for major adverse cardiovascular events at one year; however, iFR is limited by sensitive landmarking of the pressure waveform, and the assumption that maximal flow and minimal resistance occur during a fixed period of diastole. We sought to validate the resting full-cycle ratio (RFR), a novel non-hyperaemic index of coronary stenosis severity based on unbiased identification of the lowest distal coronary pressure to aortic pressure ratio (Pd/Pa), independent of the ECG, landmark identification, and timing within the cardiac cycle...
May 23, 2018: EuroIntervention
Sanjeet Singh Avtaar Singh, Nicholas R Banner, Sally Rushton, Andre R Simon, Colin Berry, Nawwar Al-Attar
BACKGROUND: Heart transplantation (HTx) remains the most effective long-term treatment for advanced heart failure. Primary graft dysfunction (PGD) continues to be a potentially life-threatening early complication. In 2014, a consensus statement released by ISHLT established diagnostic criteria for PGD. We studied the incidence of PGD across the UK. METHODS: We analysed the medical records of all adult patients who underwent heart transplantation between October 2012-October 2015 in the 6 UK heart transplant centers Preoperative donor and recipient characteristics, intraoperative details and posttransplant complications were compared between the PGD and non PGD groups using the ISHLT definition...
May 1, 2018: Transplantation
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