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https://www.readbyqxmd.com/read/28334357/sweetener-intake-by-rats-selectively-bred-for-differential-saccharin-intake-sucralose-stevia-and-acesulfame-potassium
#1
Nancy K Dess, Kiana Dobson, Brandon T Roberts, Clinton D Chapman
Behavioral responses to sweeteners have been used to study the evolution, mechanisms, and functions of taste. Occidental low and high saccharin consuming rats (respectively, LoS and HiS) have been selectively outbred on the basis of saccharin intake and are a valuable tool for studying variation among individuals in sweetener intake and its correlates. Relative to HiS rats, LoS rats consume smaller amounts of all nutritive and nonnutritive sweeteners tested to date, except aspartame. The lines also differ in intake of the commercial product Splenda; the roles of sucralose and saccharides in the difference are unclear...
March 15, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28284644/suitability-of-pharmaceuticals-and-personal-care-products-ppcps-and-artificial-sweeteners-ass-as-wastewater-indicators-in-the-pearl-river-delta-south-china
#2
Yuan-Yuan Yang, Wang-Rong Liu, You-Sheng Liu, Jian-Liang Zhao, Qian-Qian Zhang, Min Zhang, Jin-Na Zhang, Yu-Xia Jiang, Li-Juan Zhang, Guang-Guo Ying
Wastewater indicator is a useful tool for evaluating the wastewater impact on natural water, but there is little information about the suitability of wastewater indicators for different regions. This study aimed to select suitable wastewater indicators in the Pearl River Delta region, south China by screening a range of wastewater related organic compounds. The screening campaign was carried out by investigating the occurrence and removal efficiencies of 93 pharmaceuticals and personal care products (PPCPs) and 5 artificial sweeteners (ASs) in nine wastewater treatment plants (WWTPs) located in the region, and the occurrence of these target compounds in the contaminated and clean surface water of the Pearl River...
March 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28277180/simultaneous-determination-of-sodium-saccharin-aspartame-acesulfame-k-and-sucralose-in-food-consumed-in-korea-using-high-performance-liquid-chromatography-and-evaporative-light-scattering-detection
#3
Youngsun Lee, Byungkyung Do, Gunyoung Lee, Ho Soo Lim, Sang Soon Yun, Hoonjeong Kwon
Four artificial sweeteners, i.e., sodium saccharin, aspartame, acesulfame-K and sucralose, are permitted for use in Korea, and recent regulatory changes have expanded the number of food categories in which they may be used. Four artificial sweeteners were determined simultaneously in more than 900 food items from 30 food categories that are commercially available in Korean markets, including both domestic and imported products, using high-performance liquid chromatography and evaporative light-scattering detection (ELSD)...
February 17, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28228424/widespread-sucralose-exposure-in-a-randomized-clinical-trial-in-healthy-young-adults
#4
Allison C Sylvetsky, Peter J Walter, H Martin Garraffo, Kim Robien, Kristina I Rother
Background: Low-calorie sweeteners (LCSs) are found in many foods and beverages, but consumers may not realize their presence, and their role in appetite, weight, and health is controversial. Although consumption limits based on toxicologic safety are well established, the threshold required to exert clinically relevant metabolic effects is unknown.Objectives: This study aimed to determine whether individuals who do not report consumption of LCSs can be correctly characterized as "unexposed" and to investigate whether instructions to avoid LCSs are effective in minimizing exposure...
February 22, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28192727/ecotoxicological-assessments-show-sucralose-and-fluoxetine-affect-the-aquatic-plant-lemna-minor
#5
Cherisse Amy-Sagers, Keith Reinhardt, Danelle M Larson
Pharmaceuticals and personal care products (PPCP) are prevalent in aquatic systems, yet the fate and impacts on aquatic plants needs quantification for many compounds. We measured and detected sucralose (an artificial sweetener), fluoxetine (an antidepressant), and other PPCP in the Portneuf River in Idaho, USA, where Lemna minor (an aquatic plant in the environment and used in ecotoxicology studies) naturally occurs. Sucralose was hypothesized to negatively affect photosynthesis and growth of L. minor because sucralose is a chlorinated molecule that may be toxic or unusable for plant metabolism...
April 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28192132/flavor-preferences-conditioned-by-nutritive-and-non-nutritive-sweeteners-in-mice
#6
Anthony Sclafani, Karen Ackroff
Recent studies suggest that preferences are conditioned by nutritive (sucrose) but not by non-nutritive (sucralose) sweeteners in mice. Here we compared the effectiveness of nutritive and non-nutritive sweeteners to condition flavor preferences in three mouse strains. Isopreferred sucrose and sucralose solutions both conditioned flavor preferences in C57BL/6J (B6) mice but sucrose was more effective, consistent with its post-oral appetition action. Subsequent experiments compared flavor conditioning by fructose, which has no post-oral appetition effect in B6 mice, and a sucralose+saccharin mixture (SS) which is highly preferred to fructose in 24-h choice tests...
May 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28174684/sucralose-activates-an-erk1-2-ribosomal-protein-s6-signaling-axis
#7
Marcy L Guerra, Michael A Kalwat, Kathleen McGlynn, Melanie H Cobb
The sweetener sucralose can signal through its GPCR receptor to induce insulin secretion from pancreatic β cells, but the downstream signaling pathways involved are not well-understood. Here we measure responses to sucralose, glucagon-like peptide 1, and amino acids in MIN6 β cells. Our data suggest a signaling axis, whereby sucralose induces calcium and cAMP, activation of ERK1/2, and site-specific phosphorylation of ribosomal protein S6. Interestingly, sucralose acted independently of mTORC1 or ribosomal S6 kinase (RSK)...
February 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28148491/glucose-elicits-cephalic-phase-insulin-release-in-mice-by-activating-k-atp-channels-in-taste-cells
#8
John I Glendinning, Yonina G Frim, Ayelet Hochman, Gabrielle S Lubitz, Anthony J Basile, Anthony Sclafani
The taste of sugar elicits cephalic-phase insulin release (CPIR), which limits the rise in blood glucose associated with meals. Little is known, however, about the orosensory mechanisms that trigger CPIR. We asked whether oral stimulation with any of the following taste stimuli elicited CPIR in mice: glucose, sucrose, maltose, fructose, Polycose, saccharin, sucralose, AceK, SC45647 or a non-metabolizable sugar analog. The only taste stimuli that elicited CPIR were glucose and the glucose-containing saccharides (sucrose, maltose, Polycose)...
February 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28131539/acetylation-and-deacetylation-for-sucralose-preparation-by-a-newly-isolated-bacillus-amyloliquefaciens-wzs01
#9
Jie Sun, Liang Chen, Bo Lou, Yanbing Bai, Xinjun Yu, Man Zhao, Zhao Wang
Sucralose is a non-nutritive artificial sweetener used in a broad range of foods and beverages. In the present study, Bacillus amyloliquefaciens WZS01 was isolated, identified, and used as a catalyst both in regioselective acylation and deacetylation for sucralose preparation. Bacterial cells were immobilized on polyurethane foam and utilized to synthesize sucrose-6-acetate regioselectively. The yield of sucrose-6-acetate was >95% with 60 mM sucrose after 22 h of reaction. Free cells could hydrolyze 75 mM sucralose-6-acetate to produce sucralose with >99% yield after 24 h of reaction...
January 25, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28126491/the-relative-reinforcing-value-of-sweet-versus-savory-snack-foods-after-consumption-of-sugar-or-non-nutritive-sweetened-beverages
#10
Shanon L Casperson, LuAnn Johnson, James N Roemmich
The effects of sugar-sweetened (SSB) and non-nutritive sweetened (NSB) beverages on the regulation of appetite, energy intake and body weight regulation remain controversial. Using a behavioral choice paradigm, we sought to determine the effects of consuming a SSB or NSB on appetite and the reinforcing value of sweet relative to salty/savory snack foods. In a randomized crossover study, 21 healthy weight adults consumed 360 ml of SSB (sucrose; 31 g) or NSB (sucralose; 4 g) with a standardized meal. Hedonic ratings for the sweet and salty/savory snack foods used for the reinforcement task were assessed prior to the start of the study...
January 23, 2017: Appetite
https://www.readbyqxmd.com/read/28122684/enhancement-of-total-nitrogen-removal-through-effluent-recirculation-and-fate-of-ppcps-in-a-hybrid-constructed-wetland-system-treating-urban-wastewater
#11
Cristina Ávila, Catiane Pelissari, Pablo H Sezerino, Massimiliano Sgroi, Paolo Roccaro, Joan García
The effect of effluent recirculation on the removal of total nitrogen (TN) and eight pharmaceuticals and personal care products (PPCPs) was evaluated during 9months in an experimental hybrid constructed wetland (CW) system applied in the treatment of urban wastewater. An Imhoff tank was followed by three stages of CWs (two 1.5-m(2) vertical subsurface flow (VF) beds alternating feed-rest cycles, a 2-m(2) horizontal (HF) and a 2-m(2) free water surface (FWS) wetland in series). A fraction of the final effluent was recycled back to the Imhoff tank with a recirculation rate of 50% (hydraulic loading rate=0...
April 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28118138/comments-on-a-method-to-measure-sucralose-using-uv-photodegradation-followed-by-uv-spectrophotometry
#12
Te Fang, Susan A Andrews, Ron Hofmann
A simple and quick method to measure sucralose in aqueous solution at concentrations in the order of 0.1&#x2013;1.2g&#x00B7;L<sup>&#x2013;1</sup> proposed by Idris et al. uses UV irradiation prior to UV spectrophotometry. The photolysis of sucralose forms a photoactive compound characterized by maximum absorbance at approximately 270 nm. The conditions required for sucralose photolysis, however, had not been completely reported. In this work, the procedure described by Idris et al. was replicated using a low-pressure UV lamp to irradiate sucralose samples with a wider range of initial concentrations (0...
December 20, 2016: Journal of AOAC International
https://www.readbyqxmd.com/read/28113123/disruption-of-gel-phase-lipid-packing-efficiency-by-sucralose-studied-with-merocyanine-540
#13
Morgan Barker, Anthony Kennedy
Sucralose, an artificial sweetener, displays very different behavior towards membranes than its synthetic precursor sucrose. The impact of both sugars on model dipalmitoylphosphatidylcholine model membranes was investigated using absorbance and flourescence spectroscopy and the membrane probe merocyanine 540. This probe molecule is highly sensitive to changes in membrane packing, microviscosity and polarity. This work focuses on the impact of sugars on the outer leaflet of unilamellar dipalmitoyl phosphatidylcholine model membranes...
April 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28095077/running-performance-with-nutritive-and-non-nutritive-sweetened-mouth-rinses
#14
Keely H Hawkins, Sridevi Krishnan, Lara Ringos, Vanessa Garcia, Jamie A Cooper
Mouth rinsing (MR) with carbohydrate during exercise has been shown to act as an ergogenic aid. PURPOSE: To investigate if nutritive or nonnutritive sweetened MR affect exercise performance, and to assess the influence of sweetness intensity on endurance performance during a time-trial (TT). METHODS: This randomized, single blinded study had 4 treatment conditions. 16 subjects (9 men, 7 women) completed a 12.8km TT four different times. During each TT, subjects MR and expectorated a different solution at time 0 and every 12...
January 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28071796/influence-of-package-visual-cues-of-sweeteners-on-the-sensory-emotional-profiles-of-their-products
#15
Wisdom Wardy, Pitchayapat Chonpracha, Napapan Chokumnoyporn, Sujinda Sriwattana, Witoon Prinyawiwatkul, Wannita Jirangrat
Substantial evidence suggests influence of color, physical state, and other extrinsic features on consumer perception and acceptability of food products. In this study, 560 subjects evaluated liking and emotional responses associated with 5 sweeteners (sucralose, stevia, saccharin, aspartame, and sucrose) under 2 eliciting conditions: control (brand name only) and informed (brand name/packet image), to assess impact of the packet color. For a given condition, 5 identical tea samples each labeled with a sweetener type were rated for sweetness and overall liking (9-point) and emotions (5-point)...
January 10, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28040879/type-of-sweet-flavour-carrier-affects-thyroid-axis-activity-in-male-rats
#16
Pałkowska-Goździk Ewelina, Bigos Anna, Rosołowska-Huszcz Danuta
PURPOSE: Non-nutritive sweeteners are the most widely used food additives worldwide. However, their metabolic outcomes are still a matter of controversy and their effect on the thyroid activity, a key regulator of metabolism, has not been previously studied. Therefore, we aim to determine the influence of the sweet type flavour carrier on selected parameters of thyroid axis activity. METHODS: Male Sprague-Dawley rats (n = 105) were divided into 3 groups fed ad libitum for three weeks isocaloric diets (3...
December 31, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/28027980/assessment-of-the-carcinogenic-potential-of-high-intense-sweeteners-through-the-test-for-detection-of-epithelial-tumor-clones-warts-in-drosophila-melanogaster
#17
Mirley Alves Vasconcelos, Priscila Capelari Orsolin, Rosiane Gomes Silva-Oliveira, Júlio César Nepomuceno, Mário Antônio Spanó
High intensity-sweeteners (HIS) are natural or synthetic substances, sweeter than sugar, providing sweetness without calories. Sweeteners are mainly used as an aid in losing weight, preventing obesity and controlling blood sugar levels for diabetics. The objective of this study was to evaluate the carcinogenic potential of the sweeteners aspartame, sucralose, sodium saccharin and steviol glycoside, using the test for detection of epithelial tumor clones in Drosophila melanogaster. Larvae of 72 ± 4h, obtained from wts/TM3 female mated with mwh/mwh males, were treated for approximately 48h with different concentrations of aspartame (0...
March 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27988248/does-eating-good-tasting-food-influence-body-weight
#18
Michael G Tordoff, Jordan A Pearson, Hillary T Ellis, Rachel L Poole
Does eating good-tasting food influence body weight? To investigate, we first established some concentrations of sucralose and mineral oil in chow that mice strongly preferred. Then, in Experiment 1, we compared groups of 16 mice fed plain chow (i.e., chow with no additives) to groups fed chow with added (a) sucralose, (b) mineral oil, (c) sucralose and mineral oil, or (d) sucralose on odd days and mineral oil on even days. During a 6-week test, the body weights and body compositions of the five groups never differed...
March 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/27941594/the-sweetener-sensing-mechanisms-of-the-ghrelin-cell
#19
Sandra Steensels, Laurien Vancleef, Inge Depoortere
Carbohydrate administration decreases plasma levels of the 'hunger hormone' ghrelin. The ghrelin cell is co-localized with the sweet taste receptor subunit, TAS1R3, and the gustatory G-protein, gustducin, both involved in the sensing of sweeteners by entero-endocrine cells. This study investigated the role of gustducin-mediated sweet taste receptor signaling on ghrelin secretion in a gastric ghrelinoma cell line, tissue segments and mice. The monosaccharide d-glucose and low-intensity sweetener oligofructose (OFS) decreased (p < 0...
December 7, 2016: Nutrients
https://www.readbyqxmd.com/read/27925212/sucrose-replacement-in-high-ratio-white-layer-cakes
#20
Rebecca A Miller, Orelia E Dann, Amanda R Oakley, Megan E Angermayer, Katherine H Brackebusch
BACKGROUND: Several commercially available alternative sweeteners have potential in reducing the caloric content of baked products. Sugar alcohols and natural sweeteners have similar bulk as sucrose and can replace sucrose directly. High intensity sweeteners have high potency but light weight so bulking agents are often added. This study determined alternative sweeteners and combinations of alternative sweetener and a bulking agent that produced good quality white layer cakes. RESULTS: Cakes made with maltitol were acceptable but erythritol and fructose produced undesirable cakes...
December 7, 2016: Journal of the Science of Food and Agriculture
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