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https://www.readbyqxmd.com/read/29760482/glycemic-impact-of-non-nutritive-sweeteners-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#1
Alexander D Nichol, Maxwell J Holle, Ruopeng An
BACKGROUND/OBJECTIVES: Nonnutritive sweeteners (NNSs) are zero- or low-calorie alternatives to nutritive sweeteners, such as table sugars. A systematic review and meta-analysis of randomized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs. SUBJECTS/METHODS: PubMed and Web of Science databases were searched. Two authors screened the titles and abstracts of candidate publications. The third author was consulted to resolve discrepancies...
May 15, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29756702/non-nutritive-sweeteners-children-and-adolescent-consumption-and-food-sources
#2
María B Garavaglia, Vanesa Rodríguez García, María E Zapata, Alicia Rovirosa, Verónica González, Florencia Flax Marcó, Esteban Carmuega
The availability of food and beverages with non-nutritive sweeteners (NNSs) has increased in recent years. OBJECTIVES: To estimate NNSs consumption among children and adolescents in the Autonomous City of Buenos Aires, the prevalence of a daily intake higher than acceptable, and the main food and beverages contributing to it. MATERIAL AND METHODS: Descriptive study about the information collected in the First Food and Nutritional/Nutrition Survey of Buenos Aires City, which was conducted in 2011 and included 2664 children and adolescents aged 2-18 years...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29751045/detection-and-modulation-of-capsaicin-perception-in-the-human-oral-cavity
#3
Gregory Smutzer, Jeswin C Jacob, Joseph T Tran, Darshan I Shah, Shilpa Gambhir, Roni K Devassy, Eric B Tran, Brian T Hoang, Joseph F McCune
Capsaicin causes a burning or spicy sensation when this vanilloid compound comes in contact with trigeminal neurons of the tongue. This compound has low solubility in water, which presents difficulties in examining the psychophysical properties of capsaicin by standard aqueous chemosensory tests. This report describes a new approach that utilizes edible strips for delivering precise amounts of capsaicin to the human oral cavity for examining threshold and suprathreshold amounts of this irritant. When incorporated into pullulan-based edible strips, recognition thresholds for capsaicin occurred over a narrow range, with a mean value near 1 nmol...
May 8, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29742349/widespread-micropollutant-monitoring-in-the-hudson-river-estuary-reveals-spatiotemporal-micropollutant-clusters-and-their-sources
#4
Corey Carpenter, Damian E Helbling
The objective of this study was to identify sources of micropollutants in the Hudson River Estuary (HRE). We collected 127 grab samples at seventeen sites along the HRE over two years and screened for up to 200 micropollutants. We quantified 168 of the micropollutants in at least one of the samples. Atrazine, gabapentin, metolachlor, and sucralose were measured in every sample. We used data-driven unsupervised methods to cluster the micropollutants based on their spatiotemporal occurrence and normalized-concentration patterns...
May 9, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29660810/sensory-profile-drivers-of-liking-and-influence-of-information-on-the-acceptance-of-low-calorie-synbiotic-and-probiotic-chocolate-ice-cream
#5
Juliana Peres, Erick Esmerino, Alessandra Lins da Silva, Ilana Racowski, Helena Bolini
The objective of this study was to evaluate the sensory profile and the influence of the information on the acceptance of the symbiotic chocolate ice cream made with sucrose and different sweeteners (aspartame, sucralose, neotame, Stevia with 60%, 85%, 95%, and 97% of rebaudioside A) through analysis of variance (ANOVA), Tukey's test, and partial least of square (PLS) regression. Quantitative descriptive analysis (QDA) was carried out by 18 assessors, who evaluated the samples in relation to the raised descriptors...
April 16, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29660801/evaluation-of-long-term-effects-of-artificial-sweeteners-on-rat-brain-a-biochemical-behavioral-and-histological-study
#6
Oytun Erbaş, Mümin Alper Erdoğan, Asghar Khalilnezhad, Volkan Solmaz, Fulya Tuzcu Gürkan, Gürkan Yiğittürk, Hüseyin Avni Eroglu, Dilek Taskiran
The aim of the present study was to compare the effects of artificial sweeteners (aspartame, saccharin, and sucralose) on rat brain. Twenty-four adult male Sprague-Dawley rats were included in the study. The control group (n = 6) received regular tap water, whereas other groups received aspartame (3 mg/kg/day, n = 6,) or saccharin (3 mg/kg/day, n = 6) or sucralose (1.5 mg/kg/day, n = 6) in the drinking water. Following 6 weeks, the passive avoidance learning (PAL) test was performed to evaluate the neurobehavioral effects of sweeteners...
April 16, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29601264/associations-between-nonnutritive-sweetener-intake-and-metabolic-syndrome-in-adults
#7
Erica L Hess, Emily A Myers, Susan E Swithers, Valisa E Hedrick
OBJECTIVE: Individuals looking to improve their health or weight status often use nonnutritive sweeteners (NNS), yet NNS consumption has been associated with increased risk factors for metabolic syndrome (MetS). Most studies examining NNS only assess total intake using diet soda as a proxy for NNS consumption, without distinguishing potential risks associated with individual sweeteners. The objective of this cross-sectional investigation was to identify whether there were associations between NNS consumption (total or individual) and risk factors for MetS in adults (n = 125) from Southwest Virginia...
March 30, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29571111/spatial-patterns-of-pharmaceuticals-and-wastewater-tracers-in-the-hudson-river-estuary
#8
Mark G Cantwell, David R Katz, Julia C Sullivan, Daniel Shapley, John Lipscomb, Jennifer Epstein, Andrew R Juhl, Carol Knudson, Gregory D O'Mullan
The widespread use of pharmaceuticals by human populations results in their sustained discharge to surface waters via wastewater treatment plants (WWTPs). In this study, 16 highly prescribed pharmaceuticals were quantified along a 250 km transect of the Hudson River Estuary and New York Harbor to describe their sources and spatial patterns. Sampling was conducted over two dry weather periods in May and July 2016, at 72 sites which included mid-channel and nearshore sites, as well as locations influenced by tributaries and WWTP outfalls...
December 22, 2017: Water Research
https://www.readbyqxmd.com/read/29554272/the-artificial-sweetener-splenda-promotes-gut-proteobacteria-dysbiosis-and-myeloperoxidase-reactivity-in-crohn-s-disease-like-ileitis
#9
Alexander Rodriguez-Palacios, Andrew Harding, Paola Menghini, Catherine Himmelman, Mauricio Retuerto, Kourtney P Nickerson, Minh Lam, Colleen M Croniger, Mairi H McLean, Scott K Durum, Theresa T Pizarro, Mahmoud A Ghannoum, Sanja Ilic, Christine McDonald, Fabio Cominelli
Background: Epidemiological studies indicate that the use of artificial sweeteners doubles the risk for Crohn's disease (CD). Herein, we experimentally quantified the impact of 6-week supplementation with a commercial sweetener (Splenda; ingredients sucralose maltodextrin, 1:99, w/w) on both the severity of CD-like ileitis and the intestinal microbiome alterations using SAMP1/YitFc (SAMP) mice. Methods: Metagenomic shotgun DNA sequencing was first used to characterize the microbiome of ileitis-prone SAMP mice...
March 15, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29543782/low-no-calorie-sweeteners-a-review-of-global-intakes
#10
REVIEW
Danika Martyn, Maryse Darch, Ashley Roberts, Han Youl Lee, Tina Yaqiong Tian, Naoko Kaburagi, Pablo Belmar
The current review examined published data on the intake of all major low-/no-calorie sweeteners-aspartame, acesulfame-K, saccharin, sucralose, cyclamate, thaumatin and steviol glycosides-globally over the last decade. The most detailed and complex exposure assessments were conducted in Europe, following a standardized approach. Japan and Korea similarly had up-to-date and regular intake data available. The data for other Asian countries, Latin America, Australia/New Zealand and global estimates, evaluated by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), while available, were shown to be more limited in terms of design...
March 15, 2018: Nutrients
https://www.readbyqxmd.com/read/29534454/the-comparative-reproducibility-and-validity-of-a-non-nutritive-sweetener-food-frequency-questionnaire
#11
Emily A Myers, Erin M Passaro, Valisa E Hedrick
In order to better assess non-nutritive sweetener (NNS) consumption, measurement tools with greater utility are needed. The objective of this investigation is to determine the reproducibility and validity of a newly developed NNS food frequency questionnaire (NNS-FFQ) that measures five types of NNS (saccharin, aspartame, acesulfame potassium, sucralose and erythritol). Adult participants ( n = 123, 56% female, 75% Caucasian, mean age = 36.8 ± 16.6) completed the NNS-FFQ twice and had 24-h dietary recalls three times over a two-week study period...
March 10, 2018: Nutrients
https://www.readbyqxmd.com/read/29511682/noncaloric-sweeteners-in-children-a-controversial-theme
#12
REVIEW
Samuel Durán Agüero, Lissé Angarita Dávila, Ma Cristina Escobar Contreras, Diana Rojas Gómez, Jorge de Assis Costa
Noncaloric sweeteners (NCS) are food additives used to provide sweetness without adding calories. Their consumption has become more widespread around the world in all age groups, including children. The aim of this study is to show the state of the art about the intake of noncaloric sweeteners in children, as well as their benefits and consumption risk. Scientific searchers were used (PUBMED, Scopus, and Scielo) to analyze articles that included keywords (noncaloric sweeteners/saccharin/cyclamate/acesulfame potassium/aspartame/sucralose/stevia/children) in English, Spanish, and Portuguese...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29467367/removal-of-artificial-sweeteners-and-their-effects-on-microbial-communities-in-sequencing-batch-reactors
#13
Shaoli Li, Jinju Geng, Gang Wu, Xingsheng Gao, Yingying Fu, Hongqiang Ren
Concern is growing over contamination of the environment with artificial sweeteners (ASWs) because of their widespread existence in wastewater treatment plants (WWTPs). To evaluate ASWs removal and the effect on activated sludge, acesulfame (ACE), sucralose (SUC), cyclamate (CYC) and saccharin (SAC) were introduced individually or in mixture to sequencing batch reactors (SBRs) in environmentally relevant concentrations (100 ppb) for 100 days. Comparisons between ACE removal in a full-scale WWTP and in lab-scale SBRs were conducted...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29393240/increased-small-intestinal-permeability-during-severe-acute-exacerbations-of-copd
#14
Roy T M Sprooten, Kaatje Lenaerts, Dionne C W Braeken, Ilvy Grimbergen, Erica P Rutten, Emiel F M Wouters, Gernot G U Rohde
BACKGROUND: Disturbances of intestinal integrity, manifested by increased gastro-intestinal (GI) permeability, have been found in chronic obstructive pulmonary disease (COPD) patients during physical activity, often associated with intermittent hypoxic periods. Evidence about extrapulmonary organ disturbances, especially of the GI tract, during hospitalised acute exacerbation of COPD (AE-COPD) with hypoxaemic respiratory failure (RF) is lacking. OBJECTIVE: The aim was to assess changes in GI permeability in patients with AE-COPD and during recovery 4 weeks later...
January 25, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29385054/a-preliminary-study-for-evaluating-the-dose-dependent-effect-of-d-allulose-for-fat-mass-reduction-in-adult-humans-a-randomized-double-blind-placebo-controlled-trial
#15
Youngji Han, Eun-Young Kwon, Mi Kyeong Yu, Seon Jeong Lee, Hye-Jin Kim, Seong-Bo Kim, Yang Hee Kim, Myung-Sook Choi
d-allulose is a rare sugar with zero energy that can be consumed by obese/overweight individuals. Many studies have suggested that zero-calorie d-allulose has beneficial effects on obesity-related metabolism in mouse models, but only a few studies have been performed on human subjects. Therefore, we performed a preliminary study with 121 Korean subjects (aged 20-40 years, body mass index ≥ 23 kg/m²). A randomized controlled trial involving placebo control (sucralose, 0.012 g × 2 times/day), low d-allulose (d-allulose, 4 g × 2 times/day), and high d-allulose (d-allulose, 7 g × 2 times/day) groups was designed...
January 31, 2018: Nutrients
https://www.readbyqxmd.com/read/29326475/alternative-sugars-sucralose
#16
(no author information available yet)
No abstract text is available yet for this article.
January 12, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29288052/hydrophobic-interactions-of-sucralose-with-protein-structures
#17
Nimesh Shukla, Enrico Pomarico, Cody J S Hecht, Erika A Taylor, Majed Chergui, Christina M Othon
Sucralose is a commonly employed artificial sweetener that appears to destabilize protein native structures. This is in direct contrast to the bio-preservative nature of its natural counterpart, sucrose, which enhances the stability of biomolecules against environmental stress. We have further explored the molecular interactions of sucralose as compared to sucrose to illuminate the origin of the differences in their bio-preservative efficacy. We show that the mode of interactions of sucralose and sucrose in bulk solution differ subtly through the use of hydration dynamics measurement and computational simulation...
February 1, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29281655/evidence-supporting-oral-sensitivity-to-complex-carbohydrates-independent-of-sweet-taste-sensitivity-in-humans
#18
Julia Y Q Low, Kathleen E Lacy, Robert L McBride, Russell S J Keast
Compared to simple sugars, complex carbohydrates have been assumed invisible to taste. However, two recent studies proposed that there may be a perceivable taste quality elicited by complex carbohydrates independent of sweet taste. There is precedent with behavioural studies demonstrating that rats are very attracted to complex carbohydrates, and that complex carbohydrates are preferred to simple sugars at low concentrations. This suggests that rats may have independent taste sensors for simple sugars and complex carbohydrates...
2017: PloS One
https://www.readbyqxmd.com/read/29280297/hypercrosslinked-particles-for-the-extraction-of-sweeteners-using-dispersive-solid-phase-extrction-from-environmental-samples
#19
Sameer S Lakade, Qing Zhou, Aimin Li, Francesc Borrull, Núria Fontanals, Rosa M Marcé
This work presents a new extraction material, namely, Q-100, based on hypercrosslinked magnetic particles, which was tested in dispersive solid-phase extraction for a group of sweeteners from environmental samples. The hypercrosslinked Q-100 magnetic particles had the advantage of suitable pore size distribution and high surface area, and showed good retention behavior towards sweeteners. Different dispersive solid-phase extraction parameters such as amount of magnetic particles or extraction time were optimized...
December 26, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29225094/the-sweet-effect-comparative-assessments-of-dietary-sugars-on-cognitive-performance
#20
Rachel Ginieis, Elizabeth A Franz, Indrawati Oey, Mei Peng
In recent years there has been increasing interest in studying cognitive effects associated with sugar consumption. Neuro-cognitive research has confirmed that glucose, as a main energy substrate for the brain, can momentarily benefit cognitive performances, particularly for memory functioning. However, there is still limited understanding of relative effects of other common sugars (e.g., fructose and sucrose) on cognitive performance. The present study tested in 49 people the effects of three common dietary sugars against a placebo sweetener (i...
February 1, 2018: Physiology & Behavior
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