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https://www.readbyqxmd.com/read/29326475/alternative-sugars-sucralose
#1
(no author information available yet)
No abstract text is available yet for this article.
January 12, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29288052/hydrophobic-interactions-of-sucralose-with-protein-structures
#2
Nimesh Shukla, Enrico Pomarico, Cody J S Hecht, Erika A Taylor, Majed Chergui, Christina M Othon
Sucralose is a commonly employed artificial sweetener that appears to destabilize protein native structures. This is in direct contrast to the bio-preservative nature of its natural counterpart, sucrose, which enhances the stability of biomolecules against environmental stress. We have further explored the molecular interactions of sucralose as compared to sucrose to illuminate the origin of the differences in their bio-preservative efficacy. We show that the mode of interactions of sucralose and sucrose in bulk solution differ subtly through the use of hydration dynamics measurement and computational simulation...
December 26, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29281655/evidence-supporting-oral-sensitivity-to-complex-carbohydrates-independent-of-sweet-taste-sensitivity-in-humans
#3
Julia Y Q Low, Kathleen E Lacy, Robert L McBride, Russell S J Keast
Compared to simple sugars, complex carbohydrates have been assumed invisible to taste. However, two recent studies proposed that there may be a perceivable taste quality elicited by complex carbohydrates independent of sweet taste. There is precedent with behavioural studies demonstrating that rats are very attracted to complex carbohydrates, and that complex carbohydrates are preferred to simple sugars at low concentrations. This suggests that rats may have independent taste sensors for simple sugars and complex carbohydrates...
2017: PloS One
https://www.readbyqxmd.com/read/29280297/hypercrosslinked-particles-for-the-extraction-of-sweeteners-using-dispersive-solid-phase-extrction-from-environmental-samples
#4
Sameer S Lakade, Qing Zhou, Aimin Li, Francesc Borrull, Núria Fontanals, Rosa M Marcé
This work presents a new extraction material, namely, Q-100, based on hypercrosslinked magnetic particles, which was tested in dispersive solid-phase extraction for a group of sweeteners from environmental samples. The hypercrosslinked Q-100 magnetic particles had the advantage of suitable pore size distribution and high surface area, and showed good retention behavior towards sweeteners. Different dispersive solid-phase extraction parameters such as amount of magnetic particles or extraction time were optimized...
December 26, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29225094/the-sweet-effect-comparative-assessments-of-dietary-sugars-on-cognitive-performance
#5
Rachel Ginieis, Elizabeth A Franz, Indrawati Oey, Mei Peng
In recent years there has been increasing interest in studying cognitive effects associated with sugar consumption. Neuro-cognitive research has confirmed that glucose, as a main energy substrate for the brain, can momentarily benefit cognitive performances, particularly for memory functioning. However, there is still limited understanding of relative effects of other common sugars (e.g., fructose and sucrose) on cognitive performance. The present study tested in 49 people the effects of three common dietary sugars against a placebo sweetener (i...
December 7, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29214535/simultaneous-determination-of-41-multiclass-organic-pollutants-in-environmental-waters-by-means-of-polyethersulfone-microextraction-followed-by-liquid-chromatography-tandem-mass-spectrometry
#6
Leire Mijangos, Haizea Ziarrusta, Maitane Olivares, Olatz Zuloaga, Monika Möder, Nestor Etxebarria, Ailette Prieto
A new procedure using polyethersulfone (PES) microextraction followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis was developed in this work for the simultaneous determination of 41 multiclass priority and emerging organic pollutants including herbicides, hormones, personal care products, and pharmaceuticals, among others, in seawater, wastewater treatment plant (WWTP) effluents, and estuary samples. The optimization of the analysis included two different chromatographic columns and different variables (polarity, fragmentor voltage, collision energy, and collision cell accelerator) of the mass spectrometer...
December 6, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29210609/dietary-intakes-of-six-intense-sweeteners-by-irish-adults
#7
Maria Buffini, Séverine Goscinny, Joris Van Loco, Anne P Nugent, Janette Walton, Albert Flynn, Michael J Gibney, Breige A McNulty
This research investigated the intakes of six intense sweeteners: acesulfame-K (E950), aspartame (E951), cyclamate (E952), saccharin (E954), sucralose (E955), and steviol glycosides (E960) in the diets of Irish adults, using data from the National Adult Nutrition Survey. A food label survey that included products currently available on the Irish market supplemented the analysis. Sweetener intakes were investigated using three different exposure scenarios; beginning with a crude assessment which assumed that all foods permitted to contain the additives of interest always did contain them, and at their maximum permitted level (Tier 1)...
December 28, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29169565/septic-systems-contribute-to-nutrient-pollution-and-harmful-algal-blooms-in-the-st-lucie-estuary-southeast-florida-usa
#8
Brian E Lapointe, Laura W Herren, Armelle L Paule
Nutrient enrichment is a significant global-scale driver of change in coastal waters, contributing to an array of problems in coastal ecosystems. The St. Lucie Estuary (SLE) in southeast Florida has received national attention as a result of its poor water quality (elevated nutrient concentrations and fecal bacteria counts), recurring toxic Microcystis aeruginosa blooms, and its proximity to the northern boundary of tropical coral species in the United States. The SLE has an artificially large watershed comprised of a network of drainage canals, one of which (C-44) is used to lower the water level in Lake Okeechobee...
December 2017: Harmful Algae
https://www.readbyqxmd.com/read/29138943/contaminants-of-emerging-concern-in-surface-waters-in-barbados-west-indies
#9
Quincy A Edwards, Sergei M Kulikov, Leah D Garner-O'Neale, Chris D Metcalfe, Tamanna Sultana
Contaminants of emerging concern (CECs), including pharmaceuticals, artificial sweeteners, steroid hormones, and current-use pesticides have been detected in surface waters around the world, but to date, there have been no reports in the peer-reviewed literature on the levels of these classes of contaminants in freshwater resources in the Caribbean region. In the present study, multi-residue solid phase extraction (SPE) and liquid chromatography with tandem mass spectroscopy (LC-MS/MS) were used to analyze grab samples of surface waters collected from five different watersheds in Barbados, West Indies...
November 14, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29132732/the-role-of-artificial-and-natural-sweeteners-in-reducing-the-consumption-of-table-sugar-a-narrative-review
#10
REVIEW
Arshag D Mooradian, Meridith Smith, Masaaki Tokuda
The rapid increase in the prevalence of obesity worldwide has been partially attributed to the overconsumption of added sugars. Recent guidelines call for limiting the consumption of simple sugars to less than 10% of daily caloric consumption. High intensity sweeteners are regulated as food additives and include aspartame, acesulfame-k, neotame, saccharin, sucralose, cyclamate and alitame. Steviol glycosides and Luo Han Guo fruit extracts are high intensity sweeteners that are designated as generally recognized as safe (GRAS)...
April 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29130464/boronic-acid-recognition-of-non-interacting-carbohydrates-for-biomedical-applications-increasing-fluorescence-signals-of-minimally-interacting-aldoses-and-sucralose
#11
Angel Resendez, Md Abdul Halim, Jasmeet Singh, Dominic-Luc Webb, Bakthan Singaram
To address carbohydrates that are commonly used in biomedical applications with low binding affinities for boronic acid based detection systems, two chemical modification methods were utilized to increase sensitivity. Modified carbohydrates were analyzed using a two component fluorescent probe based on boronic acid-appended viologen-HPTS (4,4'-o-BBV). Carbohydrates normally giving poor signals (fucose, l-rhamnose, xylose) were subjected to sodium borohydride (NaBH4) reduction in ambient conditions for 1 h yielding the corresponding sugar alcohols from fucose, l-rhamnose and xylose in essentially quantitative yields...
November 22, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29129950/response-to-letter-to-the-editor-regarding-sylvetsky-et-al-2017-plasma-concentrations-of-sucralose-in-children-and-adults
#12
COMMENT
Allison C Meni Sylvetsky, Kristina I Rother
No abstract text is available yet for this article.
2017: Toxicological and Environmental Chemistry
https://www.readbyqxmd.com/read/29127847/effect-of-sucralose-on-the-enzyme-kinetics-of-invertase-using-real-time-nmr-spectroscopy-and-progress-curve-analysis
#13
Cheenou Her, Jaideep Singh, V V Krishnan
Sucralose, a derivative of sucrose, is widely used in noncaloric artificial sweeteners (NAS). Contrary to the belief that sucralose is physiologically inert and a healthy alternative sweetener to natural sugar, emerging studies indicate that sucralose alters the host metabolism as well as the composition of the microbiome. In this manuscript, we use real-time nuclear magnetic resonance (NMR) spectroscopy to demonstrate that sucralose alters the enzymatic conversion of sucrose to glucose and fructose. The real-time NMR progress curve analysis suggests that sucralose has the characteristic of a competitive inhibitor on the kinetics of the enzymatic process...
October 31, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/29126998/high-runner-mice-have-reduced-incentive-salience-for-a-sweet-taste-reward-when-housed-with-wheel-access
#14
Zoe Thompson, Erik M Kolb, Theodore Garland
To explore reward substitution in the context of voluntary exercise, female mice from four replicate high-runner (HR) lines (bred for wheel running) and four non-selected control (C) lines were given simultaneous access to wheels and palatable solutions as competing rewards (two doses of saccharin [0.1, 0.2% w/v]; two doses of common artificial sweetener blends containing saccharin [Sweet 'N Low(®): 0.1, 0.2% w/v], aspartame [Equal(®): 0.04, 0.08% w/v], or sucralose [Splenda(®): 0.08, 0.16% w/v]; or two doses of sucrose [3...
November 7, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/29108962/no-detriment-in-taste-response-or-expression-in-offspring-of-mice-fed-representative-levels-of-sucrose-or-non-caloric-sucralose-while-pregnant
#15
Ezen Choo, Robin Dando
Recent studies in mice indicate that consumption of acesulfame K (a high intensity sweetener) while pregnant, can lead to deficits in taste or enhanced sweet consumption in the offspring, leading to concerns the same may be common in human populations. However, this work employed a relatively unpopular sweetener, fed in quantities amounting to over 20× the FDA's Acceptable Daily Intake (ADI). The aims of this study were to test the effects of sucralose, the USA's most popular high intensity sweetener, along with sucrose, on the taste system of the offspring of mice supplemented at a level commensurate with ADIs while pregnant...
November 3, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29089128/pharmaceuticals-and-personal-care-products-ppcps-and-artificial-sweeteners-ass-in-surface-and-ground-waters-and-their-application-as-indication-of-wastewater-contamination
#16
Yuan-Yuan Yang, Jian-Liang Zhao, You-Sheng Liu, Wang-Rong Liu, Qian-Qian Zhang, Li Yao, Li-Xin Hu, Jin-Na Zhang, Yu-Xia Jiang, Guang-Guo Ying
We systematically investigated the occurrence and distribution of 93 pharmaceuticals and personal care products (PPCPs) and 5 artificial sweeteners (ASs) in surface water and groundwater of Dongjiang River basin in south China. In surface water, 52 compounds were detected with median concentrations ranging from 0.06ng/L to 504ng/L, while in groundwater, 33 compounds were detected with concentrations up to 4580ng/L for acesulfame. PPCPs and ASs were widely detected in the surface water and groundwater samples, which indicated contamination by domestic wastewater in the surface water and groundwater of Dongjiang River basin...
October 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29077645/pharmacokinetics-of-sucralose-and-acesulfame-potassium-in-breast-milk-following-ingestion-of-diet-soda
#17
Kristina I Rother, Allison C Sylvetsky, Peter J Walter, H Martin Garraffo, David A Fields
OBJECTIVE: To determine sucralose and acesulfame-K pharmacokinetics in breast milk following maternal ingestion of a diet soda. METHODS: Thirty-four exclusively breastfeeding women (14 normal weight, 20 obese) consumed twelve ounces of Diet Rite Cola™, sweetened with 68 mg sucralose and 41 mg acesulfame-potassium, prior to a standardized breakfast meal. Habitual LCS intake was assessed via a diet questionnaire. Breast milk was collected from the same breast prior to beverage ingestion and hourly for six hours...
October 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29074484/diurnal-variations-in-intestinal-barrier-integrity-and-liver-pathology-in-mice-implications-for-alcohol-binge
#18
Robin M Voigt, Christopher B Forsyth, Maliha Shaikh, Lijuan Zhang, Shohreh Raeisi, Costica Aloman, Nailliw Zanini Preite, Terrence M Donohue, Louis F Fogg, Ali Keshavarzian
Recent studies suggest that circadian rhythms regulate intestinal barrier integrity but it is not clear whether there are daily variations in barrier integrity. This study investigated daily variations in intestinal barrier integrity, including if there are differences in alcohol-induced intestinal barrier dysfunction after an alcohol binge at different times of day and if this is associated with concurrent liver injury. C57BL6/J male mice were fed a standard chow diet, an alcohol-containing liquid diet, or an alcohol control diet for four weeks...
October 26, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29074082/pullulan-based-oral-thin-film-formulation-of-zolmitriptan-development-and-optimization-using-factorial-design
#19
Vipul D Prajapati, Anita M Chaudhari, Abhishek K Gandhi, Pankaj Maheriya
The goal of study was to formulate and characterize pullulan based oral thin film (OTF) of zolmitriptan by solvent casting method. Based on preliminary trials, glass, PEG 400 and sucralose were selected as casting surface, water-miscible plasticizer and sweetener for OTF, respectively. A 3(2) factorial design was used to study the effect of amount of PEG 400 (X1) and sucralose (X2) as independent variables on tensile strength (Y1), elasticity (Y2), % in-vitro drug release in phosphate buffer of pH 6.8 at 5min (Q5min, Y3) and overall taste of OTF (Y4) as responses...
October 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28971978/activation-of-the-sweet-taste-receptor-t1r3-by-the-artificial-sweetener-sucralose-regulates-the-pulmonary-endothelium
#20
Elizabeth O Harrington, Alexander Vang, Julie Braza, Aparna Shil, Havovi Chichger
A hallmark of acute respiratory distress syndrome (ARDS) is pulmonary vascular permeability. In these settings, loss of barrier integrity is mediated by cell-contact disassembly and actin-remodelling. Studies into molecular mechanisms responsible for improving microvascular barrier function are therefore vital in the development of therapeutic targets for reducing vascular permeability in ARDS. The sweet taste receptor, T1R3 is a GPCR, activated following exposure to sweet molecules, to trigger a gustducin-dependent signal cascade...
September 28, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
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