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https://www.readbyqxmd.com/read/28618238/antiglycating-potential-of-acesulfame-potassium-an-artificial-sweetener
#1
Ahmad Ali, Tejashree Anil More, Amaritpal Kaur Hoonjan, Subramanian Sivakami
Sweeteners have replaced the natural sugars in the food and beverage industry because of many reasons such as hyperglycemia and cost. Saccharin, Sucralose, Aspartame and Acesulfame-K are the most commonly used sweeteners. In the present study, the above mentioned artificial sweeteners were used to assess their glycating properties by established methods like browning, fructosamine assay, determination of carbonyl content, protein aggregation and measurement of fluorescence. Amadori and Advanced Glycation End products (AGEs) are formed as a result of the interaction between carbonyl groups of reducing sugars and amino groups of proteins and other macromolecules during Glycation...
June 15, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28614740/investigation-of-ozonation-kinetics-and-transformation-products-of-sucralose
#2
Ruikang Hu, Lifeng Zhang, Jiangyong Hu
Sucralose is one of widely used artificial sweeteners, which has been ubiquitously detected in various water sources, such as wastewater and randomly in reservoir water. It is also reported to be persistent to various water treatment techniques. Although there are some studies on removal of sucralose by advanced oxidation process, limited information, in terms of reaction kinetics, transformation products and degradation pathway etc., was reported in its ozonation process. In this study, the reaction kinetics, removal efficiency, influence of pH, humic acid and carbonate on sucralose degradation by ozone, have been studied systematically...
June 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28605847/impact-of-on-site-small-and-large-scale-wastewater-treatment-facilities-on-levels-and-fate-of-pharmaceuticals-personal-care-products-artificial-sweeteners-pesticides-and-perfluoroalkyl-substances-in-recipient-waters
#3
Pablo Gago-Ferrero, Meritxell Gros, Lutz Ahrens, Karin Wiberg
One of the main risks associated with effluents from both wastewater treatment plants (WWTPs) and on-site sewage treatment facilities (OSSFs) is the release of micropollutants (MPs) in receiving water bodies. However, the impact of MPs present in the effluents of OSSFs in the aquatic environment has not been studied so far. The current study evaluates the impact of the effluents of OSSFs and small-to-large scale WWTPs on natural waters. The discharge of 74 MPs was assessed including pharmaceuticals, personal care products, pesticides, artificial sweeteners and perfluoroalkyl substances (PFASs)...
June 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28601791/effect-of-operational-and-water-quality-parameters-on-conventional-ozonation-and-the-advanced-oxidation-process-o3-h2o2-kinetics-of-micropollutant-abatement-transformation-product-and-bromate-formation-in-a-surface-water
#4
Marc Bourgin, Ewa Borowska, Jakob Helbing, Juliane Hollender, Hans-Peter Kaiser, Cornelia Kienle, Christa S McArdell, Eszter Simon, Urs von Gunten
The efficiency of ozone-based processes under various conditions was studied for the treatment of a surface water (Lake Zürich water, Switzerland) spiked with 19 micropollutants (pharmaceuticals, pesticides, industrial chemical, X-ray contrast medium, sweetener) each at 1 μg L(-1). Two pilot-scale ozonation reactors (4-5 m(3) h(-1)), a 4-chamber reactor and a tubular reactor, were investigated by either conventional ozonation and/or the advanced oxidation process (AOP) O3/H2O2. The effects of selected operational parameters, such as ozone dose (0...
May 11, 2017: Water Research
https://www.readbyqxmd.com/read/28587159/effects-of-low-dose-non-caloric-sweetener-consumption-on-gut-microbiota-in-mice
#5
Takashi Uebanso, Ai Ohnishi, Reiko Kitayama, Ayumi Yoshimoto, Mutsumi Nakahashi, Takaaki Shimohata, Kazuaki Mawatari, Akira Takahashi
Abstract: Non-caloric artificial sweeteners (NASs) provide sweet tastes to food without adding calories or glucose. NASs can be used as alternative sweeteners for controlling blood glucose levels and weight gain. Although the consumption of NASs has increased over the past decade in Japan and other countries, whether these sweeteners affect the composition of the gut microbiome is unclear. In the present study, we examined the effects of sucralose or acesulfame-K ingestion (at most the maximum acceptable daily intake (ADI) levels, 15 mg/kg body weight) on the gut microbiome in mice...
June 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28558975/critical-review-of-the-current-literature-on-the-safety-of-sucralose
#6
REVIEW
Bernadene A Magnuson, Ashley Roberts, Earle R Nestmann
Sucralose is a non-caloric high intensity sweetener that is approved globally for use in foods and beverages. This review provides an updated summary of the literature addressing the safety of use of sucralose. Studies reviewed include chemical characterization and stability, toxicokinetics in animals and humans, assessment of genotoxicity, and animal and human feeding studies. Endpoints evaluated include effects on growth, development, reproduction, neurotoxicity, immunotoxicity, carcinogenicity and overall health status...
May 27, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28558795/non-caloric-sweetener-provides-magnetic-resonance-imaging-contrast-for-cancer-detection
#7
Puneet Bagga, Mohammad Haris, Kevin D'Aquilla, Neil E Wilson, Francesco M Marincola, Mitchell D Schnall, Hari Hariharan, Ravinder Reddy
BACKGROUND: Image contrast enhanced by exogenous contrast agents plays a crucial role in the early detection, characterization, and determination of the precise location of cancers. Here, we investigate the feasibility of using a non-nutritive sweetener, sucralose (commercial name, Splenda), as magnetic resonance imaging (MRI) contrast agent for cancer studies. METHODS: High-resolution nuclear-magnetic-resonance spectroscopy and MR studies on sucralose solution phantom were performed to detect the chemical exchange saturation transfer (CEST) property of sucralose hydroxyl protons with bulk water (sucCEST)...
May 30, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28550797/potential-tracers-for-tracking-septic-tank-effluent-discharges-in-watercourses
#8
Samia Richards, Paul J A Withers, Eric Paterson, Colin W McRoberts, Marc Stutter
Septic tank effluent (STE) contributes to catchment nutrient and pollutant loads. To assess the role of STE discharges in impairment of surface water, it is essential to identify the sources of pollution by tracing contaminants in watercourses. We examined tracers that were present in STE to establish their potential for identifying STE contamination in two stream systems (low and high dilution levels) against the background of upstream sources. The studied tracers were microbial, organic matter fluorescence, caffeine, artificial sweeteners and effluent chemical concentrations...
May 24, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28506059/application-of-liquid-chromatography-tandem-mass-spectrometry-to-determine-urinary-concentrations-of-five-commonly-used-low-calorie-sweeteners-a-novel-biomarker-approach-for-assessing-recent-intakes
#9
Caomhan Logue, Le Roy C Dowey, J J Strain, Hans Verhagen, Stephen McClean, Alison M Gallagher
Although the use of low-calorie sweeteners (LCSs) is widespread, methods of assessing consumption within free-living populations have inherent limitations. Five commonly consumed LCSs, namely, acesulfame-K, saccharin, sucralose, cyclamate, and steviol glycosides, are excreted via the urine, and therefore a urinary biomarker approach may provide more objective LCS intake data. A LC-ESI-MS/MS method of simultaneously determining acesulfame-K, saccharin, sucralose, cyclamate, and the excretory metabolite of steviol glycosides, steviol glucuronide, in human urine was developed and validated...
June 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28502831/a-12-week-randomized-clinical-trial-investigating-the-potential-for-sucralose-to-affect-glucose-homeostasis
#10
V Lee Grotz, Xavier Pi-Sunyer, Daniel Porte, Ashley Roberts, J Richard Trout
The discovery of gut sweet taste receptors has led to speculations that non-nutritive sweeteners, including sucralose, may affect glucose control. A double-blind, parallel, randomized clinical trial, reported here and previously submitted to regulatory agencies, helps to clarify the role of sucralose in this regard. This was primarily an out-patient study, with 4-week screening, 12-week test, and 4-week follow-up phases. Normoglycemic male volunteers (47) consumed ∼333.3 mg encapsulated sucralose or placebo 3x/day at mealtimes...
May 11, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28497993/personal-variation-in-preference-for-sweetness-effects-of-age-and-obesity
#11
Nuala Bobowski, Julie A Mennella
BACKGROUND: Use of nonnutritive sweeteners (NNSs), which provide sweet taste with few to no calories, has increased, but data on whether children's hedonic responses to NNSs differ from nutritive sugars or from adults' hedonic responses are limited. METHODS: Most preferred levels of sucrose and the NNS sucralose were determined via a forced-choice tracking procedure in 48 children, 7-14 years (mean = 10 years), and 34 adults. Each participant also rated the liking of these taste stimuli, as well as varying concentrations of aspartame on 3- and 5-point facial hedonic scales...
May 12, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28489670/retrospective-comparison-of-fluticasone-propionate-and-oral-viscous-budesonide-in-children-with-eosinophilic-esophagitis
#12
Jacqueline M Fable, Marina Fernandez, Susan Goodine, Trudy Lerer, Wael N Sayej
BACKGROUND: Eosinophilic esophagitis (EoE) is treated with dietary modification and/or pharmacologic management with swallowed topical steroids (TS). Swallowed fluticasone propionate (FP) and oral viscous budesonide (OVB) have proven to be effective in resolving symptoms and reversing histologic changes in children and adults with EoE. There are minimal comparative studies between the two agents. AIM: To retrospectively compare endoscopic and histologic outcomes following FP versus OVB therapy in children with EoE in our center...
May 9, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28472098/t1r3-homomeric-sweet-taste-receptor-regulates-adipogenesis-through-g%C3%AE-s-mediated-microtubules-disassembly-and-rho-activation-in-3t3-l1-cells
#13
Yosuke Masubuchi, Yuko Nakagawa, Johan Medina, Masahiro Nagasawa, Itaru Kojima, Mark M Rasenick, Takeshi Inagaki, Hiroshi Shibata
We previously reported that 3T3-L1 cells express a functional sweet taste receptor possibly as a T1R3 homomer that is coupled to Gs and negatively regulates adipogenesis by a Gαs-mediated but cAMP-independent mechanism. Here, we show that stimulation of this receptor with sucralose or saccharin induced disassembly of the microtubules in 3T3-L1 preadipocytes, which was attenuated by overexpression of the dominant-negative mutant of Gαs (Gαs-G226A). In contrast, overexpression of the constitutively active mutant of Gαs (Gαs-Q227L) as well as treatment with cholera toxin or isoproterenol but not with forskolin caused disassembly of the microtubules...
2017: PloS One
https://www.readbyqxmd.com/read/28441725/sweet-taste-receptor-activation-in-the-gut-is-of-limited-importance-for-glucose-stimulated-glp-1-and-gip-secretion
#14
Monika Y Saltiel, Rune E Kuhre, Charlotte B Christiansen, Rasmus Eliasen, Kilian W Conde-Frieboes, Mette M Rosenkilde, Jens J Holst
Glucose stimulates the secretion of the incretin hormones: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). It is debated whether the sweet taste receptor (STR) triggers this secretion. We investigated the role of STR activation for glucose-stimulated incretin secretion from an isolated perfused rat small intestine and whether selective STR activation by artificial sweeteners stimulates secretion. Intra-luminal administration of the STR agonists, acesulfame K (3.85% w/v), but not sucralose (1...
April 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28407474/the-impact-of-low-and-no-caloric-sweeteners-on-glucose-absorption-incretin-secretion-and-glucose-tolerance
#15
Catherine B Chan, Zohre Hashemi, Fatheema B Subhan
The consumption of non-nutritive, low, or no-calorie sweeteners (LCS) is increasing globally. Previously thought to be physiologically inert, there is a growing body of evidence that LCS not only provide a sweet taste but may also elicit metabolic effects in the gastrointestinal tract. This review provides a brief overview of the chemical and receptor-binding properties and effects on chemosensation of different LCS but focuses on the extent to which LCS stimulates glucose transport, incretin and insulin secretion, and effects on glucose tolerance...
April 13, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28372222/effect-of-sweetener-combination-and-storage-temperature-on-physicochemical-properties-of-sucrose-free-white-chocolate
#16
Laura T Rodriguez Furlán, Yanina Baracco, Javier Lecot, Noemi Zaritzky, Mercedes E Campderrós
The influence of a combination of sweeteners (Stevia (St) and sucralose (Su)) and storage temperature on thermal properties, microstructure, water content, texture and Bloom of sucrose free white chocolate was investigated. A strong relationship between the microstructure and the highest percentage of Bloom was observed. The samples with 100%Su and 50%S+50%Su presented microstructures with channels through which solids and fat could more easily spread to the surface, increasing the fat and sugar Bloom formation...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28351133/monitoring-the-behavior-of-emerging-contaminants-in-wastewater-impacted-rivers-based-on-the-use-of-fluorescence-excitation-emission-matrixes-eem
#17
Massimiliano Sgroi, Paolo Roccaro, Gregory V Korshin, Federico G A Vagliasindi
This study investigated the applicability of fluorescence indexes based on the interpretation of excitation emission matrices (EEMs) by PARAFAC analysis and by selecting fluorescence intensities at a priori defined excitation/emission pairs as surrogates for monitoring the behavior of emerging organic compounds (EOCs) in two catchment basins impacted by wastewater discharges. Relevant EOC and EEM data were obtained for a 90 km stretch of the Simeto River, the main river in Sicily, and the smaller San Leonardo River, which was investigated for a 17 km stretch...
April 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28347724/metabolic-effects-of-intermittent-access-to-caloric-or-non-caloric-sweetened-solutions-in-mice-fed-a-high-caloric-diet
#18
Marion Soto, Catherine Chaumontet, Patrick C Even, Dalila Azzout-Marniche, Daniel Tomé, Gilles Fromentin
Human consumption of obesogenic diets and soft drinks, sweetened with different molecules, is increasing worldwide, and increases the risk of metabolic diseases. We hypothesized that the chronic consumption of caloric (sucrose, high-fructose corn syrup (HFCS), maltodextrin) and non-caloric (sucralose) solutions under 2-hour intermittent access, alongside the consumption of a high-fat high-sucrose diet, would result in differential obesity-associated metabolic abnormalities in mice. Male C57BL/6 mice had ad libitum access to an HFHS diet and to water (water control group)...
June 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28334357/sweetener-intake-by-rats-selectively-bred-for-differential-saccharin-intake-sucralose-stevia-and-acesulfame-potassium
#19
Nancy K Dess, Kiana Dobson, Brandon T Roberts, Clinton D Chapman
Behavioral responses to sweeteners have been used to study the evolution, mechanisms, and functions of taste. Occidental low and high saccharin consuming rats (respectively, LoS and HiS) have been selectively outbred on the basis of saccharin intake and are a valuable tool for studying variation among individuals in sweetener intake and its correlates. Relative to HiS rats, LoS rats consume smaller amounts of all nutritive and nonnutritive sweeteners tested to date, except aspartame. The lines also differ in intake of the commercial product Splenda; the roles of sucralose and saccharides in the difference are unclear...
June 1, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28284644/suitability-of-pharmaceuticals-and-personal-care-products-ppcps-and-artificial-sweeteners-ass-as-wastewater-indicators-in-the-pearl-river-delta-south-china
#20
Yuan-Yuan Yang, Wang-Rong Liu, You-Sheng Liu, Jian-Liang Zhao, Qian-Qian Zhang, Min Zhang, Jin-Na Zhang, Yu-Xia Jiang, Li-Juan Zhang, Guang-Guo Ying
Wastewater indicator is a useful tool for evaluating the wastewater impact on natural water, but there is little information about the suitability of wastewater indicators for different regions. This study aimed to select suitable wastewater indicators in the Pearl River Delta region, south China by screening a range of wastewater related organic compounds. The screening campaign was carried out by investigating the occurrence and removal efficiencies of 93 pharmaceuticals and personal care products (PPCPs) and 5 artificial sweeteners (ASs) in nine wastewater treatment plants (WWTPs) located in the region, and the occurrence of these target compounds in the contaminated and clean surface water of the Pearl River...
March 8, 2017: Science of the Total Environment
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