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Graphene cancer

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https://www.readbyqxmd.com/read/27931160/preparation-of-hollow-core-shell-fe3o4-graphene-oxide-composites-as-magnetic-targeting-drug-nanocarriers
#1
Junmei Wang, Jianjun Fang, Pan Fang, Xian Li, Shijie Wu, Wenjing Zhang, Sufang Li
A main challenge for anticancer drugs is that the drugs can not arrive the cancer tissue at right time. In this work, a magnetic targeting nanoparticle based on hollow Fe3O4/graphene oxide (Fe3O4/GO) was developed as a potential tumor targeting drug carriers. The morphology results showed the Fe3O4 nanoparticles were uniformly wrapped by graphene oxide. After coating with graphene oxide, the Fe3O4/GO showed a higher saturation magnetization of 71.47 emu g(-1) as compared to neat Fe3O4 nanoparticles. The drug loading and releasing experiment indicated the obtained Fe3O4/GO has a good loading capacity of of 0...
December 8, 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27923144/folic-acid-grafted-bovine-serum-albumin-decorated-graphene-oxide-an-efficient-drug-carrier-for-targeted-cancer-therapy
#2
Naxin Ma, Jing Liu, Wenxiu He, Zhonghao Li, Yuxia Luan, Yunmei Song, Sanjay Garg
Targeting drug carrier systems based on graphene oxide (GO) are of great interest, since it can selectively deliver anticancer drugs to tumor cells, and enhance therapeutic activities with minimized side effects. However, direct grafting target molecules on GO usually results in aggregation of physiological fluid, limiting its biomedical applications. Here, we propose a new strategy to construct targeting GO drug carrier using folic acid grafted bovine serum albumin (FA-BSA) as both the stabilizer and targeting agent...
November 29, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27920430/biomimetic-antimicrobial-cloak-by-graphene-oxide-agar-hydrogel
#3
Massimiliano Papi, Valentina Palmieri, Francesca Bugli, Marco De Spirito, Maurizio Sanguinetti, Carlotta Ciancico, Maria Chiara Braidotti, Silvia Gentilini, Luca Angelani, Claudio Conti
Antibacterial surfaces have an enormous economic and social impact on the worldwide technological fight against diseases. However, bacteria develop resistance and coatings are often not uniform and not stable in time. The challenge is finding an antibacterial coating that is biocompatible, cost-effective, not toxic, and spreadable over large and irregular surfaces. Here we demonstrate an antibacterial cloak by laser printing of graphene oxide hydrogels mimicking the Cancer Pagurus carapace. We observe up to 90% reduction of bacteria cells...
December 2016: Scientific Reports
https://www.readbyqxmd.com/read/27891534/graphene-oxide-nanosheets-stimulate-ruffling-and-shedding-of-mammalian-cell-plasma-membranes
#4
Chao Sun, Devin L Wakefield, Yimo Han, David A Muller, David A Holowka, Barbara A Baird, William R Dichtel
Graphene oxide (GO) has attracted intense interest for use in living systems and environmental applications. GO's compatibility with mammalian cells is sometimes inferred from its low cytotoxicity, but such conclusions ignore non-lethal effects that will influence GO's utility. Here we demonstrate, with rat basophilic leukemia (RBL) cells, profound plasma membrane (PM) ruffling and shedding induced by GO using confocal and live cell fluorescence microscopy, as well as scanning electron microscopy. These membrane structures contain immunoglobulin E receptors, are resistant to detergents, and lack detectable fluorescence labeling of F-actin and fibronectin...
August 11, 2016: Chem
https://www.readbyqxmd.com/read/27886602/multifunctional-nanoparticles-for-protein-detections-in-thin-channels
#5
Hweiyan Tsai, Weimin Lin, Mingchieh Chuang, Yishuan Lu, C Bor Fuh
This paper presents a method for simultaneous detection of two proteins by using multifunctional nanoparticles with a magnetic immunoassay in thin channels. Biofunctional magnetic graphene quantum dots (GQDs) combined with two biofunctional quantum dots (QDs) were used for simultaneously detecting two proteins. Magnetic GQDs enabled selective and quantitative nanoparticle deposition with blue emission. Biofunctional QDs confirmed the two protein detections with orange and green emissions. We used two model biomarkers [alpha-fetoprotein (AFP) and cancer antigen 125 (CA125)] to demonstrate the feasibility of the proposed method...
November 12, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27878179/when-biomolecules-meet-graphene-from-molecular-level-interactions-to-material-design-and-applications
#6
REVIEW
Dapeng Li, Wensi Zhang, Xiaoqing Yu, Zhenping Wang, Zhiqiang Su, Gang Wei
Graphene-based materials have attracted increasing attention due to their atomically-thick two-dimensional structures, high conductivity, excellent mechanical properties, and large specific surface areas. The combination of biomolecules with graphene-based materials offers a promising method to fabricate novel graphene-biomolecule hybrid nanomaterials with unique functions in biology, medicine, nanotechnology, and materials science. In this review, we focus on a summarization of the recent studies in functionalizing graphene-based materials using different biomolecules, such as DNA, peptides, proteins, enzymes, carbohydrates, and viruses...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27876601/bioapplications-of-graphene-constructed-functional-nanomaterials
#7
REVIEW
Arif Gulzar, Piaoping Yang, Fei He, Jiating Xu, Dan Yang, Liangge Xu, Mohammad Omar Jan
Graphene has distinctive mechanical, electronic, and optical properties, which researchers have applied to develop innovative electronic materials including transparent conductors and ultrafast transistors. Lately, the understanding of various chemical properties of graphene has expedited its application in high-performance devices that generate and store energy. Graphene is now increasing its terrain outside electronic and chemical applications toward biomedical areas such as precise bio sensing through graphene-quenched fluorescence, graphene-enhanced cell differentiation and growth, and graphene-assisted laser desorption/ionization for mass spectrometry...
November 19, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27875978/near-infrared-light-responsive-polymeric-nanocomposites-for-cancer-therapy
#8
Cong Min, Xueqing Zou, Quanzhu Yang, Liqiong Liao, Guofu Zhou, Lijian Liu
Inorganic nanoparticles, which can absorb and convert near infrared (NIR) light to heat to ablate cancer cells, have been widely investigated in photothermal therapy. However, the inherent poor solubility and acute systemic toxicity of these inorganic particles hinder their application in clinical practice. Polymeric nnanocomposites materials containing both inorganic nanoparticles and polymers could be harnessed to achieve enhanced photothermal therapeutic effect as well as improved biocompatibility and multi-responsiveness...
November 22, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27860462/improved-anticancer-photothermal-therapy-using-the-bystander-effect-enhanced-by-antiarrhythmic-peptide-conjugated-dopamine-modified-reduced-graphene-oxide-nanocomposite
#9
Jiantao Yu, Yu-Hsin Lin, Lingyan Yang, Chih-Ching Huang, Liliang Chen, Wen-Cheng Wang, Guan-Wen Chen, Junyan Yan, Saranta Sawettanun, Chia-Hua Lin
Despite tremendous efforts toward developing novel near-infrared (NIR)-absorbing nanomaterials, improvement in therapeutic efficiency remains a formidable challenge in photothermal cancer therapy. This study aims to synthesize a specific peptide conjugated polydopamine-modified reduced graphene oxide (pDA/rGO) nanocomposite that promotes the bystander effect to facilitate cancer treatment using NIR-activated photothermal therapy. To prepare a nanoplatform capable of promoting the bystander effect in cancer cells, we immobilized antiarrhythmic peptide 10 (AAP10) on the surface of dopamine-modified rGO (AAP10-pDA/rGO)...
November 8, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27853677/reduced-graphene-oxide-decorated-with-gold-nanoparticle-as-signal-amplification-element-on-ultra-sensitive-electrochemiluminescence-determination-of-caspase-3-activity-and-apoptosis-using-peptide-based-biosensor
#10
Balal Khalilzadeh, Nasrin Shadjou, Hadi Afsharan, Morteza Eskandani, Hojjatollah Nozad Charoudeh, Mohammad-Reza Rashidi
Introduction: Growing demands for ultrasensitive biosensing have led to the development of numerous signal amplification strategies. In this report, a novel electrochemiluminescence (ECL) method was developed for the detection and determination of caspase-3 activity based on reduced graphene oxide sheets decorated by gold nanoparticles as signal amplification element and horseradish peroxidase enzyme (HRP) as ECL intensity enhancing agent. Methods: The ECL intensity of the luminol was improved by using the streptavidin coated magnetic beads and HRP in the presence of hydrogen peroxide...
2016: BioImpacts: BI
https://www.readbyqxmd.com/read/27825882/a-reusable-laser-wrapped-graphene-ag-array-based-sers-sensor-for-trace-detection-of-genomic-dna-methylation
#11
Lei Ouyang, Yaowu Hu, Lihua Zhu, Gary J Cheng, Joseph Irudayaraj
Methylation is an important epigenetic DNA modification that governs gene expression. The genomic level of methylated DNA and its derivatives may serve as important indicators for the initiation and progression of cancers among other diseases. In this effort we propose a new laser wrapped graphene-Ag array as a highly sensitive Surface-enhanced Raman spectroscopy (SERS) sensor for the detection of methylated DNA (5-methylcytosine, 5mC) and its oxidation derivatives namely 5-hydroxymethylcytosine (5-hmC) and 5-carboxylcytosine (5-caC)...
September 22, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27822913/graphene-oxide-gallic-acid-nanodelivery-system-for-cancer-therapy
#12
Dena Dorniani, Bullo Saifullah, Farahnaz Barahuie, Palanisamy Arulselvan, Mohd Zobir Bin Hussein, Sharida Fakurazi, Lance J Twyman
Despite the technological advancement in the biomedical science, cancer remains a life-threatening disease. In this study, we designed an anticancer nanodelivery system using graphene oxide (GO) as nanocarrier for an active anticancer agent gallic acid (GA). The successful formation nanocomposite (GOGA) was characterized using XRD, FTIR, HRTEM, Raman, and UV/Vis spectroscopy. The release study shows that the release of GA from the designed anticancer nanocomposite (GOGA) occurs in a sustained manner in phosphate-buffered saline (PBS) solution at pH 7...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27807499/nanomaterials-incorporated-ultrasound-contrast-agents-for-cancer-theranostics
#13
Lei Fu, Heng-Te Ke
Nanotechnology provides various nanomaterials with tremendous functionalities for cancer diagnostics and therapeutics. Recently, theranostics has been developed as an alternative strategy for efficient cancer treatment through combination of imaging diagnosis and therapeutic interventions under the guidance of diagnostic results. Ultrasound (US) imaging shows unique advantages with excellent features of real-time imaging, low cost, high safety and portability, making US contrast agents (UCAs) an ideal platform for construction of cancer theranostic agents...
September 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/27786282/cristae-remodeling-causes-acidification-detected-by-integrated-graphene-sensor-during-mitochondrial-outer-membrane-permeabilization
#14
Ted D Pham, Phi Q Pham, Jinfeng Li, Anthony G Letai, Douglas C Wallace, Peter J Burke
The intrinsic apoptotic pathway and the resultant mitochondrial outer membrane permeabilization (MOMP) via BAK and BAX oligomerization, cytochrome c (cytc) release, and caspase activation are well studied, but their effect on cytosolic pH is poorly understood. Using isolated mitochondria, we show that MOMP results in acidification of the surrounding medium. BAK conformational changes associated with MOMP activate the OMA1 protease to cleave OPA1 resulting in remodeling of the cristae and release of the highly concentrated protons within the cristae invaginations...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27774142/icg-conjugated-magnetic-graphene-oxide-for-dual-photothermal-and-photodynamic-therapy
#15
Ismail Ocsoy, Nuran Isiklan, Sena Cansiz, Nalan Özdemir, Weihong Tan
Aptamer-functionalized magnetic graphene oxide conjugates loaded with indocyanine green (ICG) dye, or Apt@ICG@mGO, have been successfully developed for dual-targeted photothermal and photodynamic therapy. In general, a drug or its carrier or their dosage can be imprtant important issues in terms of toxicity. However, in this system, each component used is quite safe, biocompatibe and clean. For instance, ICG, a Food and Drug Administration (FDA) approved near-infrared (NIR) dye, serves as both a photothermal and photodynamic agent...
2016: RSC Advances
https://www.readbyqxmd.com/read/27770930/a-polyamidoamne-dendrimer-functionalized-graphene-oxide-for-dox-and-mmp-9-shrna-plasmid-co-delivery
#16
Yaming Gu, Yizhen Guo, Changyong Wang, Jiake Xu, Jianping Wu, Thomas Brett Kirk, Dong Ma, Wei Xue
It is a promising way to treat the multi drug resistance (MDR) of tumor cells in both of drug and gene methods. A polyamidoamne dendrimer functionalized graphene oxide (GO-PAMAM) was designed, which could load doxorubicin (DOX) and MMP-9 shRNA plasmid at the same time in order to achieve effective treatment to breast cancer. GO-PAMAM has a high loading capacity to DOX and pH-controlled DOX release. Besides, it has efficient gene transfer ability, the transfection efficiency is significantly better than PEI-25k in the presence of serum, and it can significantly inhibit the expression of MMP-9 protein in MCF-7 cells...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27770563/biocompatibility-and-toxicology-effects-of-graphene-oxide-in-cancer-normal-and-primary-immune-cells
#17
Iêda Maria Martinez Paino, Fabrício Santos, Valtencir Zucolotto
Graphene Oxide (GO) has received enormous attention regarding its possible applications in medical areas including cancer treatment. Nevertheless, graphene biocompatibility and its interactions with cancer, normal and immune system cells still remain a major issue. In the current study, we focused on the immunological impact of GO in the oxidative burst by GO produced in fresh isolated primary human neutrophils, the most abundant leukocyte of immune system. We also studied the GO cytotoxicity, cell uptake and genotoxicity in fresh isolated primary human monocyte, neutrophil, human carcinoma cervical (HeLa) and L929 cells...
October 22, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27769433/highly-sensitive-detection-of-acid-phosphatase-by-using-a-graphene-quantum-dots-based-f%C3%A3-rster-resonance-energy-transfer
#18
Weidan Na, Qing Liu, Bowen Sui, Tianyu Hu, Xingguang Su
A novel and effective fluorescence strategy was developed for sensitive and selective detection of acid phosphatase (ACP). A förster resonance energy transfer (FRET) biosensor was established by attaching nile red (NR) to graphene quantum dots (GQDs) via lecithin/β-Cyclodextrin (lecithin/β-CD) complex as the linker. The introduction of lecithin/β-CD would brought GQDs-NR pair close enough through both electrostatic interaction and hydrophobic interaction, thereby making the FRET occur and thus resulting in the fluorescence quenching of GQDs (donor) and meanwhile the fluorescence enhancement of NR (acceptor)...
December 1, 2016: Talanta
https://www.readbyqxmd.com/read/27754379/a-graphene-oxide-based-fluorescent-method-for-the-detection-of-human-chorionic-gonadotropin
#19
Ning Xia, Xin Wang, Lin Liu
Human chorionic gonadotropin (hCG) has been regarded as a biomarker for the diagnosis of pregnancy and some cancers. Because the currently used methods (e.g., disposable Point of Care Testing (POCT) device) for hCG detection require the use of many less stable antibodies, simple and cost-effective methods for the sensitive and selective detection of hCG have always been desired. In this work, we have developed a graphene oxide (GO)-based fluorescent platform for the detection of hCG using a fluorescein isothiocyanate (FITC)-labeled hCG-specific binding peptide aptamer (denoted as FITC-PPLRINRHILTR) as the probe, which can be manufactured cheaply and consistently...
October 13, 2016: Sensors
https://www.readbyqxmd.com/read/27739298/rapid-and-sensitive-detection-of-cancer-cells-based-on-the-photothermal-effect-of-graphene-functionalized-magnetic-microbeads
#20
Hongyan Zhang, Zhen Zhang, Yanhong Wang, Chuanchen Wu, Qingling Li, Bo Tang
A strategy based on immune-graphene oxide (GO)-magnetic microbead complex for the sensitive, rapid, portable and low-cost detection of cancer cells was developed. The high efficiency cell capture and high sensitive thermal contrast detection could be simultaneously achieved using magnetic microbeads and the photothermal effect of GOs. The temperature variation caused by irradiating the GOs with a laser was used to establish the standard curve of temperature variation and cancer cell number. Under optimal conditions, the limit of detection could reach 100 cells...
October 14, 2016: ACS Applied Materials & Interfaces
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