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Graphene cancer

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https://www.readbyqxmd.com/read/28231500/silver-nanoparticle-embedded-graphene-oxide-methotrexate-for-targeted-cancer-treatment
#1
Raj Kumar Thapa, Jae Hee Kim, Jee-Heon Jeong, Beom Soo Shin, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Combination therapies are widely investigated cancer treatment modalities. Carbon based systems such as graphene oxide (GO), plasmonic nanoparticles such as silver nanoparticles (AgNPs), and the folate analog, methotrexate (MTX), have been separately studied for their potential anticancer effects. In this study, we combined these systems to develop AgNPs-embedded GO with conjugated MTX (MTX-GO/AgNPs) and studied their folate receptor-targeted anticancer effects. Results revealed successful formation of AgNPs on GO along with MTX conjugation as suggested by UV/visible, TEM, AFM, FTIR, and XRD analysis...
February 13, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28214703/polyester-fabric-sheet-layers-functionalized-with-graphene-oxide-for-sensitive-isolation-of-circulating-tumor-cells
#2
Jiyoon Bu, Young Jun Kim, Yoon-Tae Kang, Tae Hee Lee, Jeongsuk Kim, Young-Ho Cho, Sae-Won Han
The metastasis of cancer is strongly associated with the spread of circulating tumor cells (CTCs). Based on the microfluidic devices, which offer rapid recovery of CTCs, a number of studies have demonstrated the potential of CTCs as a diagnostic tool. However, not only the insufficient specificity and sensitivity derived from the rarity and heterogeneity of CTCs, but also the high-cost fabrication processes limit the use of CTC-based medical devices in commercial. Here, we present a low-cost fabric sheet layers for CTC isolation, which are composed of polyester monofilament yarns...
February 12, 2017: Biomaterials
https://www.readbyqxmd.com/read/28213264/a-novel-electrochemical-biosensor-based-on-polyadenine-modified-aptamer-for-label-free-and-ultrasensitive-detection-of-human-breast-cancer-cells
#3
Kun Wang, Meng-Qi He, Fu-Heng Zhai, Rong-Huan He, Yong-Liang Yu
Simple, rapid, sensitive, and specific detection of cancer cells plays a pivotal role in the diagnosis and prognosis of cancer. A sandwich electrochemical biosensor was developed based on polyadenine (polydA)-aptamer modified gold electrode (GE) and polydA-aptamer functionalized gold nanoparticles/graphene oxide (AuNPs/GO) hybrid for the label-free and selective detection of breast cancer cells (MCF-7) via a differential pulse voltammetry (DPV) technique. Due to the intrinsic affinity between multiple consecutive adenines of polydA sequences and gold, polydA modified aptamer instead of thiol terminated aptamer was immobilized on the surface of GE and AuNPs/GO...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28208020/graphene-oxide-induced-perturbation-to-plasma-membrane-and-cytoskeletal-meshwork-sensitize-cancer-cells-to-chemotherapeutic-agents
#4
Jianqiang Zhu, Ming Xu, Ming Gao, Zhihong Zhang, Yong Xu, Tian Xia, Sijin Liu
The outstanding physicochemical properties endow graphene materials (e.g., graphene oxide, GO) with beneficial potentials in diverse biomedical fields such as bioimaging, drug delivery, and biomolecular detection. GO recently emerged as a chemosensitizer; however, the detailed molecular basis underlying GO-conducted sensitization and corresponding biological effects are still elusive. Based on our recent findings that GO treatment at sublethal concentrations could impair the general cellular priming state, including disorders of plasma membrane and cytoskeleton construction, we aimed here to explore the mechanism of GO as a sensitizer to make cancer cells more susceptible to chemotherapeutic agents...
February 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28193364/application-of-carbon-nanosorbent-for-prime-pass-through-cleanup-of-10-selected-local-anesthetic-drugs-in-human-plasma-samples
#5
Jian-Bo Ma, Li-Ming Zhao, Qiu-Hong Rui, Yu-Feng Liao, Yan-Min Chen, Jin Xu, Yan Zhu, Yong-Gang Zhao
A novel PRiME (process, robustness, improvements, matrix effects, ease of use) pass-through cleanup procedure has been developed to improve the existing commercially available designs. Carbon nanosorbents, i.e., magnetic modified carboxyl-graphene (Mag-CG) and magnetic modified carboxyl-carbon nanotubes (Mag-CCNTs), have been synthesised and evaluated in PRiME pass-through cleanup procedure for human plasma prior to analysis of 10 selected local anesthetic drugs by liquid chromatography-tandem quadrupole mass spectrometry (LC-MS/MS)...
April 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28193027/fluorescence-imaging-of-intracellular-telomerase-activity-using-enzyme-free-signal-amplification
#6
Min Hong, Lidan Xu, Qingwang Xue, Lu Li, Bo Tang
A novel enzyme-free signal amplification-based assay for highly sensitive in situ fluorescence imaging and detection of intracellular telomerase activity was developed by using a gold nanoflare probe-triggered mimic-hybridization chain reaction (mimic-HCR) coupled with a graphene oxide (GO) surface-anchored fluorescence signal readout pathway. The nanoflare probe consists of gold nanoparticles (AuNPs) functionalized with a dense shell of nucleic acid sequences by Au-S bond formation. The nucleic acid sequence is composed of three segments: a long thiol-labeled sequence (HS-DNA) and two short sequences (a telomerase primer sequence, "Primer-DNA", and an FAM-terminated reporter sequence, "Flare-DNA"), both of which are complementary to HS-DNA...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28192653/double-network-structured-graphene-oxide-containing-nanogels-as-photothermal-agents-for-the-treatment-of-colorectal-cancer
#7
Calogero Fiorica, Nicolò Mauro, Giovanna Pitarresi, Cinzia Scialabba, Fabio S Palumbo, Gaetano Giammona
Here, we reported the production of hyaluronic acid/polyaspartamide-based double-network nanogels for the potential treatment of colorectal carcinoma. Graphene oxide, thanks to the huge aromatic surface area, allows to easily load high amount of irinotecan (33.0% w/w) and confers to the system hyperthermic properties when irradiated with a near-infrared (NIR) laser beam. We demonstrate that the release of antitumor drug is influenced both by the pH of the external medium and the NIR irradiation process. In vitro biological studies, conducted on human colon cancer cells (HCT 116), revealed that nanogels are uptaken by the cancer cells and, in the presence of the antitumor drug, can produce a synergistic hyperthermic/cytotoxic effect...
February 20, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28191450/remotely-triggered-nano-theranostics-for-cancer-applications
#8
Alexandra Sneider, Derek VanDyke, Shailee Paliwal, Prakash Rai
Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response, and, if required, initiate secondary treatments. Recent in vivo experiments demonstrate the promise of using theranostics in the clinic. In this paper, we review the use of remotely triggered theranostic nanoparticles for cancer applications, focusing heavily on advances in the past five years. Remote triggering mechanisms covered include photodynamic, photothermal, phototriggered chemotherapeutic release, ultrasound, electro-thermal, magneto-thermal, X-ray, and radiofrequency therapies...
2017: Nanotheranostics (Syd)
https://www.readbyqxmd.com/read/28177218/ultrasensitive-photoelectrochemical-biosensing-of-cell-surface-n-glycan-expression-based-on-the-enhancement-of-nanogold-assembled-mesoporous-silica-amplified-by-graphene-quantum-dots-and-hybridization-chain-reaction
#9
Shenguang Ge, Feifei Lan, Linlin Liang, Na Ren, Li Li, Haiyun Liu, Mei Yan, Jinghua Yu
An ultrasensitive photoelectrochemical (PEC) biosensor for N-glycan expression based on the enhancement of nanogold-assembled mesoporous silica nanoparticles (GMSNs) was fabricated, which also combined with multibranched hybridization chain reaction (mHCR) and graphene quantum dots (GQDs). In this work, the localized surface plasmon resonance, mHCR and GQDs-induced signal amplification strategies were integrated exquisitely and applied sufficiently. In the fabrication, after porous ZnO spheres immobilized on the Au nanorod-modified paper working electrode were sensitized by CdTe QDs, the GMSNs were assembled on the CdTe QDs...
February 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28161572/single-wavelength-light-mediated-synergistic-bimodal-cancer-photoablation-and-amplified-photothermal-performance-by-graphene-gold-nanostar-photosensitizer-theranostics
#10
Chunhui Wu, Dan Li, Lianhui Wang, Xiaotian Guan, Yuan Tian, Hong Yang, Shun Li, Yiyao Liu
: Light-triggered nanotheranostics opens a fascinating but challenging avenue to achieve simultaneous and highly efficient anticancer outcomes for multimodal therapeutic and diagnostic modalities. Herein, a multifunctional phototheranostics based on a photosensitizer-assembled graphene/gold nanostar hybrid (GO/AuNS-PEG) was developed for cancer synergistic photodynamic (PDT) and photothermal therapy (PTT) as well as effective photothermal imaging. The stable and biocompatible GO/AuNS-PEG composite displayed a high photothermal conversion efficiency due to the enhanced optical absorbance of both graphene and gold nanostars in the near-infrared (NIR) range...
February 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28156035/few-layer-graphene-kills-selectively-tumor-cells-from-myelomonocytic-leukemia-patients
#11
Julie Russier, Verónica León, Marco Orecchioni, Eri Hirata, Patrizia Virdis, Claudio Fozza, Francesco Sgarrella, Gianaurelio Cuniberti, Maurizio Prato, Ester Vázquez, Alberto Bianco, Lucia G Delogu
In the cure of cancer, a major cause of today's mortality, chemotherapy is the most common treatment, though serious frequent challenges are encountered by current anticancer drugs. We discovered that few-layer graphene (FLG) dispersions have a specific killer action on monocytes, showing neither toxic nor activation effects on other immune cells. We confirmed the therapeutic application of graphene on an aggressive type of cancer that is myelomonocytic leukemia, where the monocytes are in their malignant form...
February 3, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28150943/graphene-oxide-decorated-with-ru-ii-polyethylene-glycol-complex-for-lysosome-targeted-imaging-and-photodynamic-photothermal-therapy
#12
Dong-Yang Zhang, Yue Zheng, Cai-Ping Tan, Jing-Hua Sun, Wei Zhang, Liang-Nian Ji, Zong-Wan Mao
The combination of photothermal therapy (PTT) and photodynamic therapy (PDT) can kill cancer cells more efficiently as compared with PTT or PDT treatment alone. In this work, we use a nanohybrid rGO-Ru-PEG composed of reduced nanographene oxide (rGO) sheet and a phosphorescent polyethylene glycol-modified Ru(II) complex (Ru-PEG) for combined PTT and PDT of cancer. The photosensitizer and imaging agent Ru-PEG is decorated onto the delivery and PTT agent rGO via - stacking and hydrophobic interactions. The chemical structure and morphology have been characterized by various methods...
February 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28114997/targeted-imaging-and-induction-of-apoptosis-of-drug-resistant-hepatoma-cells-by-mir-122-loaded-graphene-inp-nanocompounds
#13
Xin Zeng, Yi Yuan, Ting Wang, Han Wang, Xianyun Hu, Ziyi Fu, Gen Zhang, Bin Liu, Guangming Lu
BACKGROUND: Currently, graphene oxide has attracted growing attention as a drug delivery system due to its unique characteristics. Furthermore, utilization of microRNAs as biomarkers and therapeutic strategies would be particularly attractive because of their biological mechanisms and relatively low toxicity. Therefore, we have developed functionalized nanocompounds consisted of graphene oxide, quantum dots and microRNA, which induced cancer cells apoptosis along with targeted imaging...
January 23, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28112858/cooperative-strategies-for-enhancing-performance-of-photothermal-therapy-ptt-agent-optimizing-its-photothermal-conversion-and-cell-internalization-ability
#14
Baoji Du, Chongbo Ma, Guanyu Ding, Xu Han, Dan Li, Erkang Wang, Jin Wang
Photothermal conversion ability (PCA) and cell internalization ability (CIA) are two key factors for determining the performance of photothermal agents. The previous studies mostly focus on improving the PCA by exploring new photothermal nanomaterials. Herein, the authors take the hybrids of graphene and gold nanostar (GGN) as an example to investigate the gradually enhanced phototherapy effect by changing the PCA and CIA of photothermal therapy (PTT) agent simultaneously. Based on the GGN, the GGN and the reduced GGN protected by bovine serum albumin (BSA) or BSA-FA (folic acid) are prepared, which are named as GGNB, rGGNB, and rGGNB-FA, respectively...
January 23, 2017: Small
https://www.readbyqxmd.com/read/28106850/au-graphene-hybrid-plasmonic-nanostructure-sensor-based-on-intensity-shift
#15
Raed Alharbi, Mehrdad Irannejad, Mustafa Yavuz
Integrating plasmonic materials, like gold with a two-dimensional material (e.g., graphene) enhances the light-material interaction and, hence, plasmonic properties of the metallic nanostructure. A localized surface plasmon resonance sensor is an effective platform for biomarker detection. They offer a better bulk surface (local) sensitivity than a regular surface plasmon resonance (SPR) sensor; however, they suffer from a lower figure of merit compared to that one in a propagating surface plasmon resonance sensors...
January 19, 2017: Sensors
https://www.readbyqxmd.com/read/28090694/graphene-oxide-wrapped-sio2-tio2-hollow-nanoparticles-loaded-with-photosensitizer-for-photothermal-and-photodynamic-combination-therapy
#16
Yoonsun Jang, Sojin Kim, Seungae Lee, Chang-Min Yoon, Inkyu Lee, Jyongsik Jang
Graphene oxide (GO) enwrapped SiO2/TiO2 hollow nanoparticles (GO-HNP) are synthesized by stöbber method and used as a nanocarrier for loading protoporphyrin IX (PpIX). The synthesized nanoparticle has high dispersibitliy and high uniformity in diameter (ca. 50 nm). . Furthermore, this nanoparticle shows 808 nm laser induced PpIX release property (photo-induced "on-off" drug release system). The GO-HNP-PpIX is employed for inducing both photothermal therapy (PTT) and photodynamic therapy (PDT). The synergic effect of the PTT and PDT exhibits powerful anti-cancer property...
January 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28088076/in%C3%A2-vivo-visualization-of-endogenous-mir-21-using-hyaluronic-acid-coated-graphene-oxide-for-targeted-cancer-therapy
#17
Do Won Hwang, Han Young Kim, Fangyuan Li, Ji Yong Park, Dohyun Kim, Jae Hyung Park, Hwa Seung Han, Jung Woo Byun, Yun-Sang Lee, Jae Min Jeong, Kookheon Char, Dong Soo Lee
Oncogene-targeted nucleic acid therapy has been spotlighted as a new paradigm for cancer therapeutics. However, in vivo delivery issues and uncertainty of therapeutic antisense drug reactions remain critical hurdles for a successful targeted cancer therapy. In this study, we developed a fluorescence-switchable theranostic nanoplatform using hyaluronic acid (HA)-conjugated graphene oxide (GO), which is capable of both sensing oncogenic miR-21 and inhibiting its tumorigenicity simultaneously. Cy3-labeled antisense miR-21 peptide nucleic acid (PNA) probes loaded onto HA-GO (HGP21) specifically targeted CD44-positive MBA-MB231 cells and showed fluorescence recovery by interacting with endogenous miR-21 in the cytoplasm of the MBA-MB231 cells...
March 2017: Biomaterials
https://www.readbyqxmd.com/read/28079217/cisplatin-induced-self-assembly-of-graphene-oxide-sheets-into-spherical-nanoparticles-for-damaging-sub-cellular-dna
#18
Aditi Nandi, Abhik Mallick, Piyush More, Poulomi Sengupta, Nirmalya Ballav, Sudipta Basu
This report describes the hitherto unobserved cisplatin induced self-assembly of 2D-graphene oxide sheets into 3D-spherical nano-scale particles. These nanoparticles can encompass dual DNA damaging drugs simultaneously. A combination of confocal microscopy, gel electrophoresis and flow cytometry studies clearly demonstrated that these novel nanoparticles can internalize into cancer cells by endocytosis, localize into lysosomes, and damage DNA, leading to apoptosis. Cell viability assays indicated that these nanoparticles were more cytotoxic towards cancer cells compared to healthy cells...
January 12, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28069192/acoustic-cavitation-induced-generation-of-stabilizer-free-extremely-stable-reduced-graphene-oxide-nanodispersion-for-efficient-delivery-of-paclitaxel-in-cancer-cells
#19
Renu Geetha Bai, Kasturi Muthoosamy, Fiona Natalia Shipton, Sivakumar Manickam
Graphene is one of the highly explored nanomaterials due to its unique and extraordinary properties. In this study, by utilizing a hydrothermal reduction method, graphene oxide (GO) was successfully converted to reduced graphene oxide (RGO) without using any toxic reducing agents. Following this, with the use of ultrasonic cavitation, profoundly stable few layer thick RGO nanodispersion was generated without employing any stabilizers or surfactants. During ultrasonication, shockwaves from the collapse of bubbles cause a higher dispersing energy to the graphene nanosheets which surpass the forces of Van der Waal's and π-π stacking and thus pave the way to form a stable aqueous nanodispersion of graphene...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28067928/near-infrared-light-mediated-enhancement-of-reactive-oxygen-species-generation-through-electron-transfer-from-graphene-oxide-to-iron-hydroxide-oxide
#20
Yue He, Andrea Del Valle, Yu Qian, Yu-Fen Huang
Clinical applications of current photodynamic therapy (PDT) agents are often restricted to be activated only by UV and visible light, which have very poor tissue penetration depths. In this study, a new near infrared (NIR)-absorbing nanoagent based on graphene oxide decorated with iron hydroxide/oxide (GO-FeOxH) was developed for light-activated nanomaterial-mediated PDT. This nanocomposite, GO-FeOxH was prepared via the one-step electrooxidation of iron nails in an aqueous GO solution. The as-prepared GO-FeOxH showed a much higher reactive oxygen species (ROS) activity under NIR light irradiation than GO...
January 9, 2017: Nanoscale
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