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Graphene cancer

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https://www.readbyqxmd.com/read/28294236/ultrasensitive-electrochemical-detection-of-dicer1-3-utr-for-the-fast-analysis-of-alternative-cleavage-and-polyadenylation
#1
Hui Zhao, Feng Liu, Shilian Wu, Long Yang, Ya-Ping Zhang, Can-Peng Li
Alternative cleavage and polyadenylation (APA) is involved in several important biological processes in animals, e.g. cell growth and development, and cancer progression. The increasing data show that cancer cells are inclined to produce mRNA isoforms with a shortened 3'UTR undergoing APA. For example, the Dicer1 isoform with a shorter 3'untranslated region (3'UTR) was found to be overexpressed in some cancer cells, which may be used as a potential novel prognostic biomarker for cancer. In the present work, a novel electrochemical biosensor for ultrasensitive determination of Dicer1 was designed by using gold nanoparticles and p-sulfonated calix[6]arene functionalized reduced graphene oxide (Au@SCX6-rGO) as nanocarriers...
March 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/28285035/development-of-aflatoxin-b1-aptasensor-based-on-wide-range-fluorescence-detection-using-graphene-oxide-quencher
#2
Minyoung Joo, Seung Hoon Baek, Seon Ah Cheon, Hyang Sook Chun, Sung-Wook Choi, Tae Jung Park
Aflatoxin B1 (AFB1) is a carcinogenic substance produced by fungi of genus Aspergillus, especially Aspergillus flavus. Few nanograms of AFB1 that permeated through the skin is sufficient to cause liver cancer and stunted growth. In this study, a rapid aptamer-based assay for AFB1 was developed using the fluorescence quenching property of graphene oxide (GO) and a fluorescein amidite (FAM)-modified aptamer specific to AFB1. The aptamer, modified with the fluorescence dye FAM on its 5'-end, was used as a probe...
March 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28272412/multifunctional-nanographene-oxide-for-targeted-gene-mediated-thermochemotherapy-of-drug-resistant-tumour
#3
Yiping Zeng, Zhangyou Yang, Hong Li, Yuhui Hao, Cong Liu, Lin Zhu, Jing Liu, Binghui Lu, Rong Li
Drug resistance remains a major challenge for anticancer treatment, and one of the major mechanisms of drug resistance is the overexpression of drug efflux transporters in cancer. A new approach for defeating drug resistance is the use of a co-delivery strategy that utilizes small interfering RNA (siRNA) to silence the expression of efflux transporters together with a suitable anticancer drug for drug-resistant cells. In this work, multifunctional graphene capable of integrating multiple functions in one system was employed as a novel co-delivery system for siRNA and doxorubicin (Dox), as well as for the controlled release of intracellular pH-triggered and heat-triggered Dox...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28257099/electrochemical-detecting-lung-cancer-associated-antigen-based-on-graphene-gold-nanocomposite
#4
Zheng Wei, Junping Zhang, Aihua Zhang, Yanchun Wang, Xiaoping Cai
Using a Au nanoparticle/reduced graphene oxide composite (AuNP-RGO), a signal-enhanced electrochemical immunosensor without label was created to detect neuron-specific enolase (NSE). Furthermore, an environmentally-friendly method was developed to prepare AuNP-RGO by employing chitosan (CS), which served as reducing and stabilizing agent. We showed that the sensitivity of the immunosensor designed in this report was remarkably enhanced because of the numerous active sites in the sensor provided by the AuNP-RGO nanostructure...
March 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28254332/anti-bacterial-activity-of-graphene-oxide-as-a-new-weapon-nanomaterial-to-combat-multidrug-resistance-bacteria
#5
REVIEW
Mohammadreza Yousefi, Mehdi Dadashpour, Maryam Hejazi, Mohammad Hasanzadeh, Behzad Behnam, Miguel de la Guardia, Nasrin Shadjou, Ahad Mokhtarzadeh
Antibiotic resistance in microbial pathogens has become a serious health problem in the world. The increasing spread of hospital acquired infections especially in immunocompromised and cancer patients caused by multidrug-resistant (MDR) microbial pathogens is restricting the choices for impressive antibiotic therapy. So many efforts have been made to develop new compounds with antimicrobial activity. In recent years, nanoparticles, particularly graphene oxide (GO) nanoparticles have found many applications in various fields, including antibacterial action, pathogens bio detection, cancer therapy, and drug and gene delivery...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28254283/graphene-oxide-as-a-nanocarrier-for-controlled-release-and-targeted-delivery-of-an-anticancer-active-agent-chlorogenic-acid
#6
Farahnaz Barahuie, Bullo Saifullah, Dena Dorniani, Sharida Fakurazi, Govindarajan Karthivashan, Mohd Zobir Hussein, Fawzi M Elfghi
We have synthesized graphene oxide using improved Hummer's method in order to explore the potential use of the resulting graphene oxide as a nanocarrier for an active anticancer agent, chlorogenic acid (CA). The synthesized graphene oxide and chlorogenic acid-graphene oxide nanocomposite (CAGO) were characterized using Fourier transform infrared (FTIR) spectroscopy, thermogravimetry and differential thermogravimetry analysis, Raman spectroscopy, powder X-ray diffraction (PXRD), UV-vis spectroscopy and high resolution transmission electron microscopy (HRTEM) techniques...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28250854/radio-graphene-in-theranostic-perspectives
#7
REVIEW
Do Won Hwang
Owing to its unique physicochemical properties such as high surface area, notable biocompatibility, robust mechanical strength, high thermal conductivity, and ease of functionalization, 2D-layered graphene has received tremendous attention as a futuristic nanomaterial and its-associated research has been rapidly evolving in a variety of fields. With the remarkable advances of graphene especially in the biomedical realm, in vivo evaluation techniques to examine in vivo behavior of graphene are largely demanded under the hope of clinical translation...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28240167/recent-advance-in-the-cancer-bioimaging-with-graphene-quantum-dots
#8
Keheng Li, Xinna Zhao, Gang Wei, Zhiqiang Su
Fluorescent graphene quantum dots (GQDs) have attracted increasing interest in cancer bioimaging due to their stable photoluminescence (PL), high stability, low cytotoxicity, and good biocompatibility. In this review, we present the synthesis and chemical modification of GQDs firstly, and then introduce their unique physical, chemical, and biological properties like the absorption, PL, and cytotoxicity of GQDs. Finally and most importantly, the recent applications of GQDs in cancer bioimaging are demonstrated in detail, in which we focus on the biofunctionalization of GQDs for spe¬cific cancer cell imaging and real-time molecular imaging in live cells...
February 23, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28231500/silver-nanoparticle-embedded-graphene-oxide-methotrexate-for-targeted-cancer-treatment
#9
Raj Kumar Thapa, Jae Hee Kim, Jee-Heon Jeong, Beom Soo Shin, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Combination therapies are widely investigated cancer treatment modalities. Carbon based systems such as graphene oxide (GO), plasmonic nanoparticles such as silver nanoparticles (AgNPs), and the folate analog, methotrexate (MTX), have been separately studied for their potential anticancer effects. In this study, we combined these systems to develop AgNPs-embedded GO with conjugated MTX (MTX-GO/AgNPs) and studied their folate receptor-targeted anticancer effects. Results revealed successful formation of AgNPs on GO along with MTX conjugation as suggested by UV/visible, TEM, AFM, FTIR, and XRD analysis...
February 13, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28214703/polyester-fabric-sheet-layers-functionalized-with-graphene-oxide-for-sensitive-isolation-of-circulating-tumor-cells
#10
Jiyoon Bu, Young Jun Kim, Yoon-Tae Kang, Tae Hee Lee, Jeongsuk Kim, Young-Ho Cho, Sae-Won Han
The metastasis of cancer is strongly associated with the spread of circulating tumor cells (CTCs). Based on the microfluidic devices, which offer rapid recovery of CTCs, a number of studies have demonstrated the potential of CTCs as a diagnostic tool. However, not only the insufficient specificity and sensitivity derived from the rarity and heterogeneity of CTCs, but also the high-cost fabrication processes limit the use of CTC-based medical devices in commercial. Here, we present a low-cost fabric sheet layers for CTC isolation, which are composed of polyester monofilament yarns...
February 12, 2017: Biomaterials
https://www.readbyqxmd.com/read/28213264/a-novel-electrochemical-biosensor-based-on-polyadenine-modified-aptamer-for-label-free-and-ultrasensitive-detection-of-human-breast-cancer-cells
#11
Kun Wang, Meng-Qi He, Fu-Heng Zhai, Rong-Huan He, Yong-Liang Yu
Simple, rapid, sensitive, and specific detection of cancer cells plays a pivotal role in the diagnosis and prognosis of cancer. A sandwich electrochemical biosensor was developed based on polyadenine (polydA)-aptamer modified gold electrode (GE) and polydA-aptamer functionalized gold nanoparticles/graphene oxide (AuNPs/GO) hybrid for the label-free and selective detection of breast cancer cells (MCF-7) via a differential pulse voltammetry (DPV) technique. Due to the intrinsic affinity between multiple consecutive adenines of polydA sequences and gold, polydA modified aptamer instead of thiol terminated aptamer was immobilized on the surface of GE and AuNPs/GO...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28208020/graphene-oxide-induced-perturbation-to-plasma-membrane-and-cytoskeletal-meshwork-sensitize-cancer-cells-to-chemotherapeutic-agents
#12
Jianqiang Zhu, Ming Xu, Ming Gao, Zhihong Zhang, Yong Xu, Tian Xia, Sijin Liu
The outstanding physicochemical properties endow graphene materials (e.g., graphene oxide, GO) with beneficial potentials in diverse biomedical fields such as bioimaging, drug delivery, and biomolecular detection. GO recently emerged as a chemosensitizer; however, the detailed molecular basis underlying GO-conducted sensitization and corresponding biological effects are still elusive. Based on our recent findings that GO treatment at sublethal concentrations could impair the general cellular priming state, including disorders of plasma membrane and cytoskeleton construction, we aimed here to explore the mechanism of GO as a sensitizer to make cancer cells more susceptible to chemotherapeutic agents...
February 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28193364/application-of-carbon-nanosorbent-for-prime-pass-through-cleanup-of-10-selected-local-anesthetic-drugs-in-human-plasma-samples
#13
Jian-Bo Ma, Li-Ming Zhao, Qiu-Hong Rui, Yu-Feng Liao, Yan-Min Chen, Jin Xu, Yan Zhu, Yong-Gang Zhao
A novel PRiME (process, robustness, improvements, matrix effects, ease of use) pass-through cleanup procedure has been developed to improve the existing commercially available designs. Carbon nanosorbents, i.e., magnetic modified carboxyl-graphene (Mag-CG) and magnetic modified carboxyl-carbon nanotubes (Mag-CCNTs), have been synthesised and evaluated in PRiME pass-through cleanup procedure for human plasma prior to analysis of 10 selected local anesthetic drugs by liquid chromatography-tandem quadrupole mass spectrometry (LC-MS/MS)...
April 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28193027/fluorescence-imaging-of-intracellular-telomerase-activity-using-enzyme-free-signal-amplification
#14
Min Hong, Lidan Xu, Qingwang Xue, Lu Li, Bo Tang
A novel enzyme-free signal amplification-based assay for highly sensitive in situ fluorescence imaging and detection of intracellular telomerase activity was developed by using a gold nanoflare probe-triggered mimic-hybridization chain reaction (mimic-HCR) coupled with a graphene oxide (GO) surface-anchored fluorescence signal readout pathway. The nanoflare probe consists of gold nanoparticles (AuNPs) functionalized with a dense shell of nucleic acid sequences by Au-S bond formation. The nucleic acid sequence is composed of three segments: a long thiol-labeled sequence (HS-DNA) and two short sequences (a telomerase primer sequence, "Primer-DNA", and an FAM-terminated reporter sequence, "Flare-DNA"), both of which are complementary to HS-DNA...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28192653/double-network-structured-graphene-oxide-containing-nanogels-as-photothermal-agents-for-the-treatment-of-colorectal-cancer
#15
Calogero Fiorica, Nicolò Mauro, Giovanna Pitarresi, Cinzia Scialabba, Fabio S Palumbo, Gaetano Giammona
Here, we reported the production of hyaluronic acid/polyaspartamide-based double-network nanogels for the potential treatment of colorectal carcinoma. Graphene oxide, thanks to the huge aromatic surface area, allows to easily load high amount of irinotecan (33.0% w/w) and confers to the system hyperthermic properties when irradiated with a near-infrared (NIR) laser beam. We demonstrate that the release of antitumor drug is influenced both by the pH of the external medium and the NIR irradiation process. In vitro biological studies, conducted on human colon cancer cells (HCT 116), revealed that nanogels are uptaken by the cancer cells and, in the presence of the antitumor drug, can produce a synergistic hyperthermic/cytotoxic effect...
March 13, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28191450/remotely-triggered-nano-theranostics-for-cancer-applications
#16
Alexandra Sneider, Derek VanDyke, Shailee Paliwal, Prakash Rai
Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response, and, if required, initiate secondary treatments. Recent in vivo experiments demonstrate the promise of using theranostics in the clinic. In this paper, we review the use of remotely triggered theranostic nanoparticles for cancer applications, focusing heavily on advances in the past five years. Remote triggering mechanisms covered include photodynamic, photothermal, phototriggered chemotherapeutic release, ultrasound, electro-thermal, magneto-thermal, X-ray, and radiofrequency therapies...
2017: Nanotheranostics
https://www.readbyqxmd.com/read/28177218/ultrasensitive-photoelectrochemical-biosensing-of-cell-surface-n-glycan-expression-based-on-the-enhancement-of-nanogold-assembled-mesoporous-silica-amplified-by-graphene-quantum-dots-and-hybridization-chain-reaction
#17
Shenguang Ge, Feifei Lan, Linlin Liang, Na Ren, Li Li, Haiyun Liu, Mei Yan, Jinghua Yu
An ultrasensitive photoelectrochemical (PEC) biosensor for N-glycan expression based on the enhancement of nanogold-assembled mesoporous silica nanoparticles (GMSNs) was fabricated, which also combined with multibranched hybridization chain reaction (mHCR) and graphene quantum dots (GQDs). In this work, the localized surface plasmon resonance, mHCR and GQDs-induced signal amplification strategies were integrated exquisitely and applied sufficiently. In the fabrication, after porous ZnO spheres immobilized on the Au nanorod-modified paper working electrode were sensitized by CdTe QDs, the GMSNs were assembled on the CdTe QDs...
March 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28161572/single-wavelength-light-mediated-synergistic-bimodal-cancer-photoablation-and-amplified-photothermal-performance-by-graphene-gold-nanostar-photosensitizer-theranostics
#18
Chunhui Wu, Dan Li, Lianhui Wang, Xiaotian Guan, Yuan Tian, Hong Yang, Shun Li, Yiyao Liu
Light-triggered nanotheranostics opens a fascinating but challenging avenue to achieve simultaneous and highly efficient anticancer outcomes for multimodal therapeutic and diagnostic modalities. Herein, a multifunctional phototheranostics based on a photosensitizer-assembled graphene/gold nanostar hybrid (GO/AuNS-PEG) was developed for cancer synergistic photodynamic (PDT) and photothermal therapy (PTT) as well as effective photothermal imaging. The stable and biocompatible GO/AuNS-PEG composite displayed a high photothermal conversion efficiency due to the enhanced optical absorbance of both graphene and gold nanostars in the near-infrared (NIR) range...
February 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28156035/few-layer-graphene-kills-selectively-tumor-cells-from-myelomonocytic-leukemia-patients
#19
Julie Russier, Verónica León, Marco Orecchioni, Eri Hirata, Patrizia Virdis, Claudio Fozza, Francesco Sgarrella, Gianaurelio Cuniberti, Maurizio Prato, Ester Vázquez, Alberto Bianco, Lucia G Delogu
In the cure of cancer, a major cause of today's mortality, chemotherapy is the most common treatment, though serious frequent challenges are encountered by current anticancer drugs. We discovered that few-layer graphene (FLG) dispersions have a specific killer action on monocytes, showing neither toxic nor activation effects on other immune cells. We confirmed the therapeutic application of graphene on an aggressive type of cancer that is myelomonocytic leukemia, where the monocytes are in their malignant form...
February 3, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28150943/graphene-oxide-decorated-with-ru-ii-polyethylene-glycol-complex-for-lysosome-targeted-imaging-and-photodynamic-photothermal-therapy
#20
Dong-Yang Zhang, Yue Zheng, Cai-Ping Tan, Jing-Hua Sun, Wei Zhang, Liang-Nian Ji, Zong-Wan Mao
The combination of photothermal therapy (PTT) and photodynamic therapy (PDT) can kill cancer cells more efficiently as compared with PTT or PDT treatment alone. In this work, we use nanohybrid rGO-Ru-PEG composed of reduced nanographene oxide (rGO) sheet and a phosphorescent polyethylene glycol modified Ru(II) complex (Ru-PEG) for combined PTT and PDT of cancer. Photosensitizer and imaging agent Ru-PEG is decorated onto delivery and PTT agent rGO via π-π stacking and hydrophobic interactions. The chemical structure and morphology have been characterized by various methods...
March 1, 2017: ACS Applied Materials & Interfaces
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