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https://www.readbyqxmd.com/read/29775731/targeted-and-controlled-drug-delivery-by-multifunctional-mesoporous-silica-nanoparticles-with-internal-fluorescent-conjugates-and-external-polydopamine-and-graphene-oxide-layers
#1
Anh-Vy Tran, KyuHwan Shim, Thu-Thao Vo Thi, Jeong-Keun Kook, Seong Soo A An, Sang-Wha Lee
This study demonstrated the targeted delivery and controlled release of cisplatin drug molecules from doubly decorated mesoporous silica nanoparticles (MSNs), which were internally grafted with fluorescent conjugates and externally coated with polydopamine (PDA) and graphene oxide (GO) layers. The brush-like internal conjugates conferred fluorescent functionality and high capacity of cisplatin loading into MSNs, as well as contributing to a sustained release of the cisplatin through a porous channel with the assistance of external PDA layer...
May 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29764213/a-novel-non-invasive-strategy-for-low-level-laser-induced-cancer-therapy-by-using-new-ag-zno-and-nd-zno-functionalized-reduced-graphene-oxide-nanocomposites
#2
Saeed Jafarirad, Ebrahim Hammami Torghabe, Seyed Hosseyn Rasta, Roya Salehi
In the present research, an effective drug-free approach was developed to kill MCF7 breast cancer cells using low-level laser therapy (LLLT) combined with reduced graphene oxide (rGO)-based hybrid nanocomposites (NCs). Here, fruit extract of Rosa canina was used for the first time to obtain the rGO/ZnO, Ag-ZnO/rGO and Nd-ZnO/rGO NCs by green synthesis. Physico/photochemical properties of these NCs were evaluated using FTIR, XRD, Raman, XPS, SEM/EDX, UV-Vis, DLS and AFM. The potential of the as-synthesized NCs on ROS generating and antioxidant activity were assessed by DPPH...
May 15, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29763376/antitumor-effect-of-go-peg-dox-complex-on-emt-6-mouse-breast-cancer-cells
#3
Jinyin Yan, Bo Song, Wanning Hu, Ying Meng, Fengling Niu, Xiaochen Han, Yuhui Ge, Ning Li
OBJECTIVE: Doxorubicin (DOX) can be used to treat malignant tumors, but with multiple adverse effects. Graphene oxide-polyethylene glycol (GO-PEG) is a novel nanoscale carrier material and can elevate solubility and biocompatibility of drugs. This study prepared a GO-PEG-DOX complex, whose toxicity and antitumor effects were evaluated on mouse EMT-6 breast cancer cells. MATERIALS AND METHODS: GO-PEG-DOX complex was prepared for calculating the drug carrier rate of DOX on GO-PEG by MV approach...
May 2018: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29759240/reduced-graphene-oxide-zno-nanocomposite-based-electrochemical-sensor-for-sensitive-and-selective-monitoring-of-8-hydroxy-2-deoxyguanosine
#4
Junxing Hao, Kangbing Wu, Chidan Wan, Yong Tang
Developing reliable and feasible electrochemical sensors for the detection of 8-hydroxy-2'-deoxyguanosine (8-OHdG) is important because the urinary level of 8-OHdG is related to cancer disease. Moreover, the co-existed uric acid (UA) as an interference severe affects the sensitive detection of 8-OHdG. Herein, sensitive monitoring of 8-OHdG was conducted using a nanocomposite of reduced graphene oxide (rGO) and ZnO nanoparticles (ZnO@rGO) as the sensing material. This nanocomposite was prepared via in-situ reduction of GO with Zn powders...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29759176/carbon-nanosphere-based-fluorescence-aptasensor-for-targeted-detection-of-breast-cancer-cell-mcf-7
#5
Dandan Yang, Mei Liu, Jing Xu, Chao Yang, Xiaoxiao Wang, Yongbing Lou, Nongyue He, Zhifei Wang
In this work, carbon nanosphere (CNS)-based fluorescence "turn off/on" aptasensor was developed for targeted detection of breast cancer cell MCF-7 by conjugation with FAM (a dye)-labeled mucin1 (MUC1) aptamer P0 (P0-FAM), which can recognize MUC1 protein overexpressed on the surface of MCF-7. Different from other carbon based fluorescence quenching materials, CNSs prepared by the carbonization of glucose not only have the high fluorescence quenching efficiency (98.8%), but also possess negligible cytotoxicity (in the concentration range of 0-1 mg/mL, which is 10 times higher than that of traditional carbon nanotubes or graphene oxide (0-100 µg/mL))...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29757340/polyethylene-glycol-and-octa-arginine-dual-functionalized-nanographene-oxide-an-optimization-for-efficient-nucleic-acid-delivery
#6
Rana Imani, Satya Prakash, Hojatollah Vali, Shahab Faghihi
The successful application of nucleic acid-based therapy for the treatment of various cancers is largely dependent on a safe and efficient delivery system. A dual-functionalized graphene oxide (GO)-based nanocarrier with the conjugation of aminated-polyethylene glycol (PEG-diamine) and octa-arginine (R8) for the intracellular delivery of nucleic acids is proposed. The functionalized sites are covalently co-conjugated and the PEG : R8 molar ratio is optimized at 10 : 1 to achieve a hydrocolloidally stable size of 252 ± 2...
May 14, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29753166/double-determination-of-long-noncoding-rnas-from-lung-cancer-via-multi-amplified-electrochemical-genosensor-at-sub-femtomole-level
#7
Xiaoyan Li, Gang Peng, Feng Cui, Qianying Qiu, Xiaojun Chen, He Huang
An ultrasensitive electrochemical genosensor has been fabricated for the double determination of two different specific sequences deduced from the maternally expressed gene3 (MEG3) lncRNA (long noncoding RNA), which was demonstrated by coupling RNase A-aided target recycling with DNA supersandwich-induced signal enhancement, based on a composite interface of graphene-like tungsten disulfide/dendritic gold nanostructures (WS2 /DGN). Firstly, duple target sequences of T1 and T2 were captured by the primer probes of P1 /P2 functionalized Fe3 O4 @C magnetic nanoparticles, via the DNA/RNA hybridization between T1 /T2 and P1 /P2 ...
May 2, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29753165/diagnosis-of-egfr-exon21-l858r-point-mutation-as-lung-cancer-biomarker-by-electrochemical-dna-biosensor-based-on-reduced-graphene-oxide-functionalized-ordered-mesoporous-carbon-ni-oxytetracycline-metallopolymer-nanoparticles-modified-pencil-graphite-electrode
#8
Yalda Shoja, Ahmad Kermanpur, Fathallah Karimzadeh
In this present work we made a novel, fast, selective and sensitive electrochemical genobiosensor to detection of EGFR exon 21 point mutation based on two step electropolymerization of Ni(II)-oxytetracycline conducting metallopolymer nanoparticles (Ni-OTC NPs) on the surface of pencil graphite electrode (PGE) which was modified by reduced graphene oxide/carboxyl functionalized ordered mesoporous carbon (rGO/f-OMC) nanocomposite. ssDNA capture probe with amine groups at the5' end which applied as recognition element was immobilized on the rGO/f-OMC/PGE surface via the strong amide bond...
April 14, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29752102/cyclodextrin-and-dendrimer-conjugated-graphene-oxide-as-a-nanocarrier-for-the-delivery-of-selected-chemotherapeutic-and-photosensitizing-agents
#9
Ampornphan Siriviriyanun, Ya-Ju Tsai, Siew Hui Voon, Siaw Fui Kiew, Toyoko Imae, Lik Voon Kiew, Chung Yeng Looi, Won Fen Wong, Hong Boon Lee, Lip Yong Chung
In this study, nanohybrid materials consisting of graphene oxide (GO), β‑cyclodextrin (CD) and poly(amido amine) dendrimer (DEN) were successfully prepared by covalent bonding. GO-CD and GO-CD-DEN were found to be potential nanocarriers for anticancer drugs including chemotherapeutics (doxorubicin (DOX), camptothecin (CPT)) and photosensitizer (protoporphyrin IX (PpIX)). GO-CD possessed 1.2 times higher DOX-loading capacity than GO due to inclusion of additional DOX to the CD. The drug loading on GO-CD-DEN increased in the order: DOX < PpIX < CPT...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752084/amphiphilic-prodrug-decorated-graphene-oxide-as-a-multi-functional-drug-delivery-system-for-efficient-cancer-therapy
#10
Chunzhi Huang, Jilian Wu, Wei Jiang, Ruiling Liu, Zhonghao Li, Yuxia Luan
Graphene oxide (GO) has shown great potential in drug delivery. However, the aqueous stability, non-specific drug release and slow release rate are major problems of the GO-based drug delivery system. Herein, we for the first time integrate the dispersant, stabilizing agent and active targeting carrier into a novel drug delivery system based on GO/PP-SS-DOX nanohybrids. The redox-sensitive PP-SS-DOX prodrug was obtained by conjugating mPEG-PLGA (PP) with doxorubicin (DOX) via disulfide bond. PEG-FA provided active targeting property for the constructed drug delivery system, GO/PP-SS-DOX/PEG-FA...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29746967/modification-of-sterculia-gum-polysaccharide-via-network-formation-by-radiation-induced-crosslinking-polymerization-for-biomedical-applications
#11
Baljit Singh, Baldev Singh
AIMS: Keeping in view the therapeutic and pharmaceutical applications of sterculia gum polysaccharide in consideration, its modification has been carried out through grafting and crosslinking to develop the hydrogels for enhanced biomedical applications. Radiation method was used for formation of sterile network of sterculia gum, carbopol and graphene oxide (GO). These polymers were characterized by Cryo-SEMs, AFM, 13 C NMR solid state, swelling studies. Some biomedical properties of hydrogels like thrombogenicity, haemolytic potential, antioxidant activity, mucoadhesion and gel strength were determined along with the drug delivery studies...
May 7, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29742484/cost-effective-three-dimensional-ag-polymer-dyes-graphene-carbon-spheres-hybrids-for-high-performance-nonenzymatic-sensor-and-its-application-in-living-cell-h-2-o-2-detection
#12
Baoping Lu, Xuna Yuan, Yuehong Ren, Qinghua Shi, Song Wang, Jinlong Dong, Ze-Dong Nan
We describe a facile method to synthesize a new type of catalyst by electrodepositing Ag nanocrystals (AgNCs) on the different polymer dyes, Poly (methylene blue) (PMB) or Poly (4-(2-Pyridylazo)-Resorcinol) (PAR) modified graphene‑carbon spheres (GS) hybrids. The self-assembled GS take dual advantages of carbon spheres and graphene. Carbon spheres acts as nano-spacers prevent the aggregation of graphene and guarantee the fast electron transfer of GS. Secondly, polymerized dyes used here are beneficial for AgNCs growing as a linker...
May 3, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29732885/measurement-of-the-extracellular-ph-of-adherently-growing-mammalian-cells-with-high-spatial-resolution-using-a-voltammetric-ph-microsensor
#13
Raluca-Elena Munteanu, Luciana Stanica, Mihaela Gheorghiu, Szilveszter Gaspar
There are only a few tools suitable for measuring the extracellular pH of adherently growing mammalian cells with high spatial resolution, and none of them is widely used in laboratories around the world. Cell biologists very often limit themselves to measuring the intracellular pH with commercially available fluorescent probes. Therefore, we have built a voltammetric pH microsensor and investigated its suitability for monitoring the extracellular pH of adherently growing mammalian cells. The voltammetric pH microsensor consisted of a 37 µm diameter carbon fiber microelectrode modified with reduced graphene oxide and syringaldazine...
May 7, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29732070/isotopic-graphene-isolated-au-nanocrystals-with-cellular-raman-silent-signals-for-cancer-cell-pattern-recognition
#14
Yuxiu Zou, Siqi Huang, Yixin Liao, Xupeng Zhu, Yiqin Chen, Long Chen, Fang Liu, Xiaoxiao Hu, Haijun Tu, Liang Zhang, Zhangkun Liu, Zhuo Chen, Weihong Tan
For cancer diagnosis, technologies must be capable of molecular recognition, and they must possess a built-in pattern recognition component for efficient imaging and discrimination of targeted cancer cells. Surface enhanced Raman scattering (SERS) tags based on plasmonically active nanoparticles hold promise for accurate and efficient cancer cell recognition, owing to ultra-narrow peak and sensitive optical properties. However, a complex fingerprint spectrum increases data analysis difficulty, making it necessary to develop multicolor SERS tags with a simple fingerprint spectrum...
March 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29730956/recent-progress-of-functionalized-graphene-oxide-in-cancer-therapy
#15
Lingyun Yi, Yanan Zhang, Xiaoqun Shi, Xiyou Du, Xinyi Wang, Aihua Yu, Guangxi Zhai
In recent years, graphene oxide (GO) nanomaterials have attracted wide attention due to their large surface area, strong light sensitivity and good biocompatibility in cancer treatment. The rich oxygen-containing functional groups on the surface provide it with the opportunity to be modified by many functional molecules to expand biological applications and reduce toxicity. In this review, the properties of GO and the methods of surface modification are presented, and the toxicity of GO is analyzed. In addition, the current applications of GO in cancer diagnoses and treatments including biological imaging, drug and gene delivery, phototherapy, and imaging-mediated combination therapy are summarized...
May 7, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29722257/graphene-oxide-facilitated-comprehensive-analysis-of-cellular-nucleic-acid-binding-proteins-for-lung-cancer
#16
Zhi Shang, Liqiang Qian, Sha Liu, Xiaomin Niu, Zhi Qiao, Yan Sun, Yan Zhang, Liu-Yin Fan, Xin Guan, Cheng-Xi Cao, Hua Xiao
Nucleic acid binding proteins (NABPs) mediate a broad range of essential cellular functions. However, it is very challenging to comprehensively extract whole cellular NABPs due to the lack of approaches with high efficiency. To this end, carbon nanomaterials, including Graphene Oxide (GO), Carboxylated Graphene (cG), and Carboxylated Carbon Nanotube (cCNT), were utilized to extract cellular NABPs in this study through a new strategy. Our data demonstrated that GO, cG, and cCNT could extract nearly 100% cellular DNA in vitro...
May 3, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29721093/graphene-oxide-sensitizes-cancer-cells-to-chemotherapeutics-by-inducing-early-autophagy-events-promoting-nuclear-trafficking-and-necrosis
#17
Kuan-Chen Lin, Mei-Wei Lin, Mu-Nung Hsu, Guan Yu-Chen, Yu-Chan Chao, Hsing-Yu Tuan, Chi-Shiun Chiang, Yu-Chen Hu
Rationale: Cisplatin (CDDP) is a broad-spectrum anticancer drug but chemoresistance to CDDP impedes its wide use for cancer therapy. Autophagy is an event occurring in the cytoplasm and cytoplasmic LC3 puncta formation is a hallmark of autophagy. Graphene oxide (GO) is a nanomaterial that provokes autophagy in CT26 colon cancer cells and confers antitumor effects. Here we aimed to evaluate whether combined use of GO with CDDP (GO/CDDP) overcomes chemoresistance in different cancer cells and uncover the underlying mechanism...
2018: Theranostics
https://www.readbyqxmd.com/read/29710679/effects-of-polymer-coated-boron-nitrides-with-increased-hemorheological-compatibility-on-human-erythrocytes-and-blood-coagulation
#18
Jeong-Ho Kim
BACKGROUND: Boron nitride (BN) nanomaterials are promising in biomedical research owing to their large surface area, graphene-like structure, and chemical and thermal properties. However, the toxicological effects of BN on erythrocytes and blood coagulation remain uninvestigated. OBJECTIVE: The aims of our study were to synthesize glycol chitosan (GC)- and hyaluronic acid (HA)-coated BNs, and to investigate the effects of these BNs on human cancer cells, erythrocytes, and whole blood...
April 14, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29708240/a-facile-graphene-oxide-based-fluorescent-nanosensor-for-the-in-situ-turn-on-detection-of-telomerase-activity
#19
Li Zhang, Jie Peng, Ming-Fang Hong, Jia-Qing Chen, Ru-Ping Liang, Jian-Ding Qiu
A facile and sensitive method for the quantitative detection of telomerase and in situ imaging of intracellular telomerase is developed by using a graphene oxide (GO)-based fluorescent nanosensor. The nanosensor consists of a fluorescent DNA (P1) adsorbed on the GO surface. Here, GO serves not only as a fluorescence quencher but also as a carrier to successfully transport P1 into cancer cells as a signal reporter. P1 is a dye-labeled single-stranded DNA complementary to the telomeric repeated sequence, and initially the combination of P1 and GO exhibits minimal background fluorescence...
April 30, 2018: Analyst
https://www.readbyqxmd.com/read/29705108/facile-preparation-of-antibacterial-chitosan-graphene-oxide-ag-bio-nanocomposite-hydrogel-beads-for-controlled-release-of-doxorubicin
#20
Monireh Rasoulzadehzali, Hassan Namazi
The present project describes the facile preparation of novel pH-sensitive bio-nanocomposite hydrogel beads based on chitosan (CH) and GO-Ag nanohybrid particles for controlled release of anti-cancer drugs such as doxorubicin (DOX). The loading efficiency of doxorubicin into test beads was measured via UV-vis spectroscopy analysis and was found to be high. The formation of silver nanoparticles on the GO sheets and structural characteristics were evaluated via FT-IR, TEM, XRD, and SEM techniques. In addition, the antibacterial activity, swelling and drug release profiles of prepared nanocomposite beads were evaluated...
April 26, 2018: International Journal of Biological Macromolecules
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