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Neutropenia Fever

Toby A Eyre, Graham P Collins, Avinash Gupta, Nicholas Coupe, Semira Sheikh, John Whittaker, Lai Mun Wang, Leticia Campo, Elizabeth Soilleux, Finn Tysoe, Richard Cousins, Nick La Thangue, Lisa K Folkes, Michael R L Stratford, David Kerr, Mark R Middleton
BACKGROUND: In the current study, the authors sought to determine the maximum tolerated dose (MTD) of the novel class 1 selective histone deacetylase inhibitor CXD101 in a dose escalation study in patients with advanced solid tumors or recurrent/refractory lymphoma. METHODS: The authors escalated the dose of CXD101 from 1 mg twice daily orally for 5 days in a 21-day cycle (3+3 design). RESULTS: A total of 39 patients were enrolled, 36 of whom received CXD101...
October 17, 2018: Cancer
Fabrice Denis, Eric Voog, Yoann Pointreau, Hugues Bourgeois, Valérie Seegers, Katell Le Du
BACKGROUND: We aimed to investigate whether patient self-evaluated symptoms transmitted via Internet is feasible between planned visits to provide an early management of fever and neutropenia induced by chemotherapy, and if it can reduce hospitalizations for severe neutropenia. METHODS: Patients who received a chemotherapy regimen with an overall risk of febrile neutropenia ≥ 20% had to report daily temperature between physician planned visits using a web application...
October 10, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Anna S Świerzko, Mateusz Michalski, Anna Sokołowska, Mateusz Nowicki, Łukasz Eppa, Agnieszka Szala-Poździej, Iwona Mitrus, Anna Szmigielska-Kapłon, Małgorzata Sobczyk-Kruszelnicka, Katarzyna Michalak, Aleksandra Gołos, Agnieszka Wierzbowska, Sebastian Giebel, Krzysztof Jamroziak, Marek L Kowalski, Olga Brzezińska, Steffen Thiel, Jens C Jensenius, Katarzyna Kasperkiewicz, Maciej Cedzyński
We conducted a prospective study of 312 patients (194 with multiple myeloma, 118 with lymphomas) receiving high-dose conditioning chemotherapy and autologous hematopoietic stem cell transplantation (auto-HSCT). Polymorphisms of MBL2 and MASP2 genes were investigated and serial measurements of serum concentrations of mannose-binding lectin (MBL), CL-LK collectin and MASP-2 as well as activities of MBL-MASP-1 and MBL-MASP-2 complex were made. Serum samples were taken before conditioning chemotherapy, before HSCT and once weekly after (totally 4-5 samples); in minority of subjects also 1 and/or 3 months post transplantation...
2018: Frontiers in Immunology
Emma J Quinn, Allena H-C Cheong, Julie K Calvert, Geoffrey Higgins, Trish Hahesy, David L Gordon, Jillian M Carr
Reported cases of dengue are rising in South Australia (SA) in travellers returning from dengue-endemic regions. We have undertaken a retrospective analysis to identify the clinical and laboratory characteristics of patients returning to SA with suspected dengue virus (DENV) infection. From 488 requests, 49 (10%) were defined by serology as acute dengue, with the majority of patients (75%) testing as non-structural protein 1 (NS1) and/or IgM positive. Dengue was most commonly acquired in Indonesia (42.9%) with clinical features of fever (95%), headache (41%) and myalgia/arthralgia (56%)...
January 7, 2018: Tropical Medicine and Infectious Disease
Sam E Grigg, Patrick Date, Zoe Loh, Ortis Estacio, Douglas F Johnson, Eliza A Hawkes, Andrew Grigg
PURPOSE: There is a paucity of data regarding the utility of routine urine cultures in adults with febrile neutropenia (FN) without urinary symptoms receiving protocolised antibiotics. This is reflected by inconsistent recommendations in international and regional FN guidelines. We addressed this issue by retrospectively reviewing the impact of routine urine cultures on antibiotic management in haematology cancer inpatients at a tertiary hospital. METHODS: All haematology inpatients over a 5-year period (2011-2015) were retrospectively reviewed for episodes of FN (neutrophil count < 0...
September 27, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Basit Siddiqui, Rabeea Azmat, Shiyam Sunder Tikmani, Shumaila Rafi, Beenish Syed, Muhammad Tahir Khan, Hareem Rehman, Saleemullah Paracha
Introduction: About 20% of febrile neutropenic patients are presented with bloodstream infection which is a leading cause of mortality among these patients. Awareness of the locally prevalent pathogens and their susceptibility pattern is important for proper treatment of infection which improves survival in these patients. The objective of this study was to determine the frequency of bloodstream infection in patients with febrile neutropenia admitted in Abbasi Shaheed Hospital. Methods: This cross-sectional study was conducted in the Medical wards in Abbasi Shaheed Hospital, Karachi from 21-2-2016 to 20-8-2017...
October 2018: Annals of Medicine and Surgery
Wenjun Deng, Mingyi Zhao, Yingting Liu, Lizhi Cao, Minghua Yang
Fanconi anemia (FA) is a rare inherited disease caused by mutations in genes that are primarily involved in DNA damage response or repair. The disease is often characterized by congenital malformations, progressive bone marrow failure, abnormal skin pigmentation patterns and susceptibility to cancer. The present study describes a pair of 4-year-old male twins, both of whom had been suffering from upper respiratory tract infections for >2 years. There was no indication of discomfort including fever, coughing, bleeding or fatigue from either child when the upper respiratory tract infection disappeared...
October 2018: Oncology Letters
Florian Pelzer, Wilfried Tröger, Dr Rer Nat
OBJECTIVES: Evaluate the safety and clinical response of complementary treatment with European mistletoe extracts during chemotherapy. DESIGN: Monocentric controlled trial with 95 patients randomized into three groups. SETTINGS/LOCATION: National Cancer Research Center of Serbia. SUBJECTS: Breast cancer patients (stage T1-3 N0-2 M0 ) undergoing surgery and adjuvant chemotherapy with six cycles of cyclophosphamide, adriamycin, and 5-fluorouracil...
September 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
José Carlos Jaime-Pérez, Lorena Salazar-Cavazos, Patrizia Aguilar-Calderón, José Luis Herrera-Garza, César Homero Gutiérrez-Aguirre, David Gómez-Almaguer
Efficacy of an ambulatory hematopoietic stem cell transplant (HSCT) program with a reduced intensity conditioning regimen (RIC) in malignant hematological diseases was assessed. We analyzed 217 patients who underwent HSCT from August 2013 to July 2017. There were 78 (35.9%) HLA-identical, 56 (25.8%) haploidentical, and 83 (38.2%) autologous transplants. Two-year transplant-related mortality (TRM) for HLA-identical, haploidentical, and auto grafts were 20%, 25%, and 2.5%; relapse/progression was 44%, 60%, and 55%; overall survival (OS) was 61%, 44...
September 21, 2018: Bone Marrow Transplantation
Soetkin Kennes, Dirk Van de Putte, Jo Van Dorpe, Vanessa Van Hende, Tessa Kerre, Philip Vlummens
OBJECTIVES: Since primary intestinal aspergillosis is a severe infectious complication with a high morbidity and mortality in immunocompromised patients, we want to draw attention to this rare entity and the importance of early recognition. METHODS: We report a case of documented primary intestinal aspergillosis in a patient receiving an autologous stem cell transplantation (SCT). Furthermore, this article gives a short reflection on the occurrence of invasive aspergillosis in autologous SCT and the value of serum galactomannan levels based on literature search and linked with the case...
September 21, 2018: Acta Clinica Belgica
Kathy Monroe, Clay T Cohen, Kimberly Whelan, Amber King, Lisa Maloney, Janet Deason, John Charles Nichols, Gregory K Friedman, Matthew Kutny, Leslie Hayes
Introduction: In patients who are immunocompromised, fever may indicate a life-threatening infection. Prompt time to antibiotic administration in febrile patients at risk for neutropenia has been identified by national and international panels as a key benchmark of quality care in emergent situations. A quality improvement initiative to improve health care provided in a pediatric emergency department (ED) is described. Methods: A clinical pathway was previously initiated in a pediatric ED with a goal of improving time to antibiotics for febrile neutropenia patients...
July 2018: Pediatric Quality & Safety
Lee S Schwartzberg, Lincy S Lal, Sanjeev Balu, Kim Campbell, Lee Brekke, Caitlin Elliott, Stephanie Korrer
Background: Filgrastim and other granulocyte colony-stimulating factors are recommended to decrease febrile neutropenia (FN) incidence among patients with nonmyeloid cancers undergoing chemotherapy. Data comparing biosimilar filgrastim-sndz with reference filgrastim (filgrastim-ref) are limited outside of clinical trials in the US. Objective: To compare the incidence of FN across chemotherapy cycles 1-6 between patients treated with filgrastim-sndz vs filgrastim-ref...
2018: ClinicoEconomics and Outcomes Research: CEOR
Juliane Léger, Isabelle Oliver, Danielle Rodrigue, Anne-Sophie Lambert, Régis Coutant
R1 The diagnosis of Graves' disease in children is based on detecting a suppression of serum TSH concentrations and the presence of anti-TSH receptor antibodies. 1/+++. R2 Thyroid ultrasound is unnecessary for diagnosis, but can be useful for assessing the size and homogeneity of the goiter. 2/+. R3. Thyroid scintigraphy is not required for the diagnosis of Graves' disease. 1/+++. R4. The measurement of T4L and T3L levels is not necessary for the diagnosis of Graves' disease in children but can be useful for the management and assessment of prognosis...
August 16, 2018: Annales D'endocrinologie
Theodore E Warkentin, Pierre-Aurèle Morin, Nancy M Heddle
BACKGROUND: Transfusion-associated anaphylaxis has been associated with anti-immunoglobulin A (anti-IgA) of IgG class in patients with IgA deficiency. In recent years, however, the frequency and clinical impact of this syndrome has been questioned. We present a case of recurrent red blood cell (RBC) transfusion-associated anaphylactoid reactions (rigors, hypertension, transient monocytopenia, and neutropenia) associated with anti-IgA. CASE REPORT: An 88-year-old woman developed anemia after a traumatic right humerus fracture...
October 2018: Transfusion
Kazuaki Kameda, Shun-Ichi Kimura, Yukiko Misaki, Kazuki Yoshimura, Ayumi Gomyo, Jin Hayakawa, Masaharu Tamaki, Machiko Kusuda, Yu Akahoshi, Tomotaka Ugai, Yuko Ishihara, Koji Kawamura, Kana Sakamoto, Aki Tanihara, Hidenori Wada, Miki Sato, Kiriko Terasako-Saito, Misato Kikuchi, Hideki Nakasone, Shinichi Kako, Yoshinobu Kanda
Infection and inflammation can induce acute graft-vs.-host disease (aGVHD). We hypothesized that febrile neutropenia early after allogeneic hematopoietic cell transplantation (HCT) would increase the risk of aGVHD and non-relapse mortality (NRM). We retrospectively evaluated the impact of fever, C-reactive protein (CRP) concentration and blood stream infection (BSI) early after HCT on the incidence of grade II-IV aGVHD and NRM in 227 patients. Within 7 days after HCT, 91 (40.1%) patients experienced fever for at least 2 days (early-FN group)...
August 31, 2018: Bone Marrow Transplantation
Ali Arash Anoshirvani, Nader Zarinfar, Mohammad Rafiee, Zahra Zamani
AIM: This study aimed to compare the effect of Imipenem monotherapy and combination therapy with Ceftazidime/Amikacin in febrile episodes in neutropenic cancer patients. MATERIALS AND METHODS: In this double-blind randomised trial, 122 adult patients with cancer, neutropenia and fever who were treated by chemotherapy were gathered by simple sampling method and were divided randomly to two equal Imipenem (IP) and Ceftazidime/Amikacin (CA) groups. 500 mg of Imipenem was administered every 6 hours IP group and 2 g of Ceftazidimeplus 15 mg/kg/day in 2 equally divided doses of Amikacin was administered in the CA group...
August 20, 2018: Open Access Macedonian Journal of Medical Sciences
Kashif Ali, Ali Akbar Sial, Mirza Tasawer Baig, Nida Baig, Saqib Hussain Ansari, Tahir Sultan Shamsi
Background: Reactivation of hepatitis B virus (HBV) and hepatitis C virus (HCV) and febrile neutropenia (FN) are common in diffuse large B-cell lymphoma (DLBCL) patients undergoing cyclophosphamide, hydroxyrubicin, Oncovin, and prednisolone (CHOP) or cyclophosphamide, hydroxyrubicin, Oncovin, prednisolone - rituximab containing (R-CHOP) chemotherapy. This ultimately leads to delaying the therapy, increasing hospital stay, and raising the pharmacoeconomic burden on patients. Aim and Objective: The aim of this study was to determine the incidence of HBV and HCV infection and febrile neutropenia in DLBCL patients treated with R-CHOP and CHOP...
June 2018: Hospital Pharmacy
Sonia Parikh, Parijat Goswami, Asha Anand, Harsha Panchal, Apurva Patel, Rahul Kulkarni, Bhadresh Shastri
BACKGROUND: The primary objective of this study is to describe clinical and microbiological profile of infections during induction phase of acute myeloid leukemia (AML). PATIENTS AND METHODS: We reviewed the case records of 50 hospitalized patients with AML undergoing standard dose induction chemotherapy from January to December 2015. RESULTS: Out of 50 cases, 34 were males 16 females with median age of 30 years. Most common presenting symptoms were fever followed by bleeding diathesis...
May 2018: Gulf Journal of Oncology
Rima Moghnieh, Dania Abdallah, Lyn Awad, Tamima Jisr, Anas Mugharbil, Ali Youssef, Hani Tamim, Samer Khaldieh, Oula Massri, Najat Rashini, Youssef Hamdan, Ahmad Ibrahim
PURPOSE: In this study, we assessed the incidence, contributing factors and outcome of prolonged neutropenia above 7 days and of bacteraemia in patients with lymphoma and multiple myeloma who underwent autologous haematopoietic stem cell transplantation (AHSCT) without antibacterial prophylaxis. METHODS: This is a retrospective chart review of 190 adult patients who underwent AHSCT between 2005 and 2015 at a Lebanese hospital. RESULTS: Neutropenia of 7 days duration and longer was documented in 66% of the patient population...
August 24, 2018: Infection
Abdulkerim Yıldız, Hacer Ba Öztürk, Murat Albayrak, Çiğdem Pala, Osman Şahin, Senem Maral, Harika Okutan
Background Prophylaxis is strongly recommended in patients with hematological malignancy who are usually at higher risk for infection and neutropenic fever. It is still unclear whether or not there is a definite need for antimicrobial prophylaxis in intermediate-risk hematology patients such as those with lymphoma. Methods A retrospective analysis was made of patients admitted from January 2009 to December 2017 to the Hematology Department of Diskapi Yildirim Beyazit Training and Research Hospital, a tertiary referral hospital in Ankara, Turkey...
August 22, 2018: Journal of Oncology Pharmacy Practice
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