Yi Wang, Hong-Dong Shi, Hai-Lin Zhang, Yu- Yu Chen, Bing Ren, Qi Tang, Qi Sun, Qian-Ling Zhang, Jin-Gang Liu
In recent years, antimicrobial resistance (AMR) has become one of the greatest threats to human health. There is an urgent need to develop new antibacterial agents to effectively treat AMR infection. Herein, a novel nanozyme platform {Cu, N-GQDs@Ru-NO} was prepared, where Cu, N-doped graphene quantum dots (Cu, N-GQDs) were covalently functionalized with a nitric oxide (NO) donor, ruthenium nitrosyl (Ru-NO). Under 808 nm near infrared (NIR) light irradiation, {Cu, N-GQDs@Ru-NO} demonstrated nicotinamide adenine dinucleotide (NADH) dehydrogenase-like activity for photo-oxidizing NADH to NAD+ , thus disrupting the redox balance in bacterial cells and resulting in bacterial death; meanwhile, the onsite NIR light-delivered NO effectively eradicated the methicillin-resistant staphylococcus aureus (MRSA) bacterial and biofilms, and promoted wound healing; furthermore, the nanozyme showed excellent photothermal effect that enhanced the antibacterial efficacy as well...
June 16, 2023: Advanced Healthcare Materials