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congenital tremors

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https://www.readbyqxmd.com/read/29885794/congenital-tremor-in-piglets-is-bovine-viral-diarrhea-virus-an-etiological-cause
#1
Marina Lopes Mechler, Felipe Dos Santos Gomes, Karla Alvarenga Nascimento, Andressa de Souza-Pollo, Felipe Ferreira Barbosa Pires, Samir Issa Samara, Edviges Maristela Pituco, Luís Guilherme de Oliveira
Congenital tremor in pigs involves several etiologies, including pestivirus, which may cause neurological injuries in different animal species. To evaluate whether bovine viral diarrhea virus (BVDV), an important pestivirus, is one of the etiological agents of congenital tremor in swine, gilts and the fetuses were challenged at 45 days of gestation with BVDV-2. Four pregnant gilts were inoculated oronasally, four gilts underwent fetal intrauterine inoculation, and two gilts constituted the control group. Antibody titers were determined by virus neutralization (VN), and viral RNA was detected by RT-PCR...
July 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29761653/detection-of-porcine-circovirus-like-virus-p1-in-hebei-china
#2
L Wen, A Mao, F Jiao, D Zhang, J Xie, K He
Porcine circovirus-like virus P1 is a novel unclassified circovirus that was first detected in China and may be associated with post-weaning multisystemic wasting syndrome (PMWS) and congenital tremor. In this study, we detected P1 infection in pigs in Hebei Province, China, in 2017. One hundred and forty of 500 (28.0%) serum samples from 25 pig farms with different PMWS status in seven cities were P1 positive on PCR. Twelve P1 strains were sequenced, and the complete genomes of 11 P1 strains were 648 nucleotides (nt) in length, whereas that of strain ZJK02 was 647 nt, with a G deletion at position of 183 in its genome...
May 14, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29606732/first-report-of-atypical-porcine-pestivirus-in-piglets-with-congenital-tremor-in-canada
#3
Fanny G Dessureault, Martin Choinière, Chantale Provost, Carl A Gagnon
No abstract text is available yet for this article.
April 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/29527814/frequent-infection-of-wild-boar-with-atypical-porcine-pestivirus-appv
#4
G N Cagatay, A Antos, D Meyer, C Maistrelli, O Keuling, P Becher, A Postel
The recently identified atypical porcine pestivirus (APPV) was demonstrated to be the causative agent of the neurological disorder "congenital tremor" in newborn piglets. Despite its relevance and wide distribution in domestic pigs, so far nothing is known about the situation in wild boar, representing an important wild animal reservoir for the related classical swine fever virus. In this study, 456 wild boar serum samples obtained from northern Germany were investigated for the presence of APPV genomes and virus-specific antibodies...
August 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29441694/presynaptic-congenital-myasthenic-syndrome-with-altered-synaptic-vesicle-homeostasis-linked-to-compound-heterozygous-sequence-variants-in-rph3a
#5
Ricardo A Maselli, Jessica Vázquez, Leah Schrumpf, Juan Arredondo, Marian Lara, Jonathan B Strober, Peter Pytel, Robert L Wollmann, Michael Ferns
BACKGROUND: Monogenic defects of synaptic vesicle (SV) homeostasis have been implicated in many neurologic diseases, including autism, epilepsy, and movement disorders. In addition, abnormal vesicle exocytosis has been associated with several endocrine dysfunctions. METHODS: We report an 11 year old girl with learning disabilities, tremors, ataxia, transient hyperglycemia, and muscle fatigability responsive to albuterol sulfate. Failure of neuromuscular transmission was confirmed by single fiber electromyography...
May 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29393592/detection-of-atypical-porcine-pestivirus-in-brazil-in-the-central-nervous-system-of-suckling-piglets-with-congenital-tremor
#6
I R H Gatto, K Harmon, L Bradner, P Silva, D C L Linhares, P H Arruda, L G de Oliveira, B L Arruda
Atypical porcine pestivirus (APPV) has been detected in piglets with congenital tremor (CT) from three different continents including North America, Europe and Asia. Thirteen piglets from four farms in two different states in Brazil with CT were sampled. Viral RNA was detected by quantitative real-time PCR in the cerebellum or cerebellum and spinal cord in the 100% of the piglets with CT, and APPV was not detected in any tissue sample from clinically non-affected piglets with the exception of the cerebellum of one piglet from Farm A...
April 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29391028/improvement-of-severe-myalgic-encephalomyelitis-chronic-fatigue-syndrome-symptoms-following-surgical-treatment-of-cervical-spinal-stenosis
#7
Peter C Rowe, Colleen L Marden, Scott Heinlein, Charles C Edwards
BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a potentially disabling disorder. Little is known about the contributors to severe forms of the illness. We describe three consecutive patients with severe ME/CFS whose symptoms improved after recognition and surgical management of their cervical spinal stenosis. METHODS: All patients satisfied clinical criteria for ME/CFS and orthostatic intolerance, and were later found to have cervical spinal stenosis...
February 2, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29322653/viruses-associated-with-congenital-tremor-and-high-lethality-in-piglets
#8
F Possatti, S A Headley, R A Leme, A M Dall Agnol, E Zotti, T E S de Oliveira, A F Alfieri, A A Alfieri
The recently described atypical porcine pestivirus (APPV) has been associated with congenital tremor (CT) type A-II in piglets in different countries. Another important neurological pathogen of pigs is porcine teschovirus (PTV), which has been associated with non-suppurative encephalomyelitis in pigs with severe or mild neurological disorders. There have been no reports of APPV and/or PTV coinfection associated with CT or encephalomyelitis in Brazilian pig herds. The aim of this study was to describe the pathological and molecular findings associated with simultaneous infection of APPV and PTV in piglets with clinical manifestations of CT that were derived from a herd with high rates of CT-associated lethality...
April 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29284212/identification-and-characterization-of-atypical-porcine-pestivirus-genomes-in-newborn-piglets-with-congenital-tremor-in-china
#9
Hanqin Shen, Xiangcong Liu, Pengfei Zhang, Lei Wang, Yanling Liu, Leyi Zhang, Pengshuai Liang, Changxu Song
Recently, a novel atypical porcine pestivirus (APPV) in pig was reported. In this study, two APPV strains, APPV-China/GZ01/2016 (GZ01) and APPV-China/GD-SD/2016 (GD-SD), were identified in two newborn piglet herds with congenital tremor from China. The open reading frame of the two strains shared an 83.5% nucleotide identity. Phylogenetically, the APPV strains were placed into two groups: GZ01 belonged to group I and GD-SD belonged to group II. A high viral load was detected in the cerebellum (quantification cycles < 26)...
May 31, 2018: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29178610/evidence-of-porcine-circovirus-like-virus-p1-in-piglets-with-an-unusual-congenital-tremor
#10
L Wen, A Mao, F Jiao, D Zhang, J Xie, K He
Outbreaks of trembling and shaking were reported among pigs at two pig farms in Jiangsu Province, China. Serum and tissue samples tested positive for porcine circovirus-like virus P1 and negative for classical swine fever virus, porcine circovirus type 2, astrovirus and porcine pestivirus using PCR/RT-PCR and immunohistochemical techniques. High P1 viral genome loads were identified in sera, brain and lymph node tissue samples by qPCR. In addition, one of the most notable pathological changes was dissolution of the nucleus in Purkinje cells...
April 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29168350/breakpoint-mapping-and-haplotype-analysis-of-translocation-t-1-12-q43-q21-1-in-two-apparently-independent-families-with-vascular-phenotypes
#11
Tiia Maria Luukkonen, Mana M Mehrjouy, Minna Pöyhönen, Anna-Kaisa Anttonen, Päivi Lahermo, Pekka Ellonen, Lars Paulin, Niels Tommerup, Aarno Palotie, Teppo Varilo
BACKGROUND: The risk of serious congenital anomaly for de novo balanced translocations is estimated to be at least 6%. We identified two apparently independent families with a balanced t(1;12)(q43;q21.1) as an outcome of a "Systematic Survey of Balanced Chromosomal Rearrangements in Finns." In the first family, carriers (n = 6) manifest with learning problems in childhood, and later with unexplained neurological symptoms (chronic headache, balance problems, tremor, fatigue) and cerebral infarctions in their 50s...
January 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29144025/detection-of-atypical-porcine-pestivirus-in-semen-from-commercial-boar-studs-in-the-united-states
#12
I R H Gatto, P H Arruda, C A Visek, J G Victoria, A R Patterson, A C Krull, K J Schwartz, L G de Oliveira, B L Arruda
Atypical porcine pestivirus (APPV) has recently been identified as a cause of congenital tremor (CT) in pigs and has been detected in semen and preputial swabs from boars that were known to be clinically affected with CT. Accordingly, the objectives of this study were to 1) detect the presence of APPV in semen, preputial fluids and preputial swabs from adult boars by quantitative reverse transcription PCR (qRT-PCR) and 2) genetically characterize a subset of positive samples to better understand the ecology of APPV in commercial boar studs and the potential risk of transmission of APPV via semen...
April 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29119697/presence-of-atypical-porcine-pestivirus-appv-in-brazilian-pigs
#13
A C S Mósena, M N Weber, R A S da Cruz, S P Cibulski, M S da Silva, D E Puhl, M E Hammerschmitt, K L Takeuti, D Driemeier, D E S N de Barcellos, C W Canal
Recently, a putative new pestivirus species, provisionally named as Atypical Porcine Pestivirus (APPV), was associated with the congenital tremor in piglets in North America and consequently in Europe and Asia. The present research aimed to describe the detection and characterization of APPV employing NS5B gene partial sequencing, gross pathology and histologic examination of piglets displaying congenital tremor from two different farms of Southern Brazil. No gross lesions were observed, and the histological findings revealed moderate vacuolization of the white matter of the cerebellum...
February 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29031627/development-of-a-sybr-green-based-real-time-quantitative-pcr-assay-to-detect-pcv3-in-pigs
#14
Gui-Hua Chen, Xiao-Yu Tang, Yuan Sun, Ling Zhou, Di Li, Yang Bai, Kai-Jie Mai, Yi-Yun Li, Qi-Wen Wu, Jing-Yun Ma
Porcine circovirus 3 (PCV3) has been reported in cases of porcine dermatitis and nephropathy syndrome, reproductive failure, cardiac and multi-systemic inflammation. A SYBR green-based real-time quantitative PCR (qPCR) assay was established in this study to detect PCV3 in 203 clinical samples from suckling piglets affected by congenital tremors in China. The limit of detection (LOD) of PCV3 was 1.73×104 copies/μL for gel electrophoresis and 1.73×102 copies/μL for SYBR green-based real-time qPCR. The melt curve analysis showed a single melt peak at 82...
January 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/28975769/detection-and-genome-sequencing-of-porcine-circovirus-3-in-neonatal-pigs-with-congenital-tremors-in-south-china
#15
G H Chen, K J Mai, L Zhou, R T Wu, X Y Tang, J L Wu, L L He, T Lan, Q M Xie, Y Sun, J Y Ma
Porcine circovirus 3 (PCV3) is a novel circovirus first discovered in the United States in piglets and sows with porcine dermatitis and nephropathy syndrome, reproductive failure, cardiac and multisystemic inflammation. Here, seven PCV3 strains were identified for the first time from neonatal pigs with clinical signs of congenital tremors (CT) in South China. The tissue tropism of PCV3 in CT-affected piglets was analysed by the real-time quantitative PCR, and the result showed that high loads of viral genomes were detected in the brains and hearts...
December 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28941140/first-report-of-the-novel-atypical-porcine-pestivirus-in-spain-and-a-retrospective-study
#16
S Muñoz-González, A Canturri, M Pérez-Simó, J A Bohórquez, R Rosell, O Cabezón, J Segalés, M Domingo, L Ganges
This study aimed to provide information regarding viral pathogenesis and molecular epidemiology linked with recently reported atypical porcine pestivirus (APPV) strains and to determine the circulation of APPV in Spain from 1997 to 2016. Two-day-old piglets with moderate-severe congenital tremor (CT) from a Spanish farm were received for diagnostic purposes. Sera, nasal and rectal swabs and tissue samples were collected. qRT-PCR was performed in these samples, and a retrospective study to detect APPV RNA was carried out using a serum collection from 1997 to 2016...
December 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28710801/phylogenetic-and-genomic-characterization-of-a-novel-atypical-porcine-pestivirus-in-china
#17
H Zhang, W Wen, G Hao, Y Hu, H Chen, P Qian, X Li
Atypical porcine pestivirus (APPV) has been considered a novel pestivirus and causative agent of congenital tremor type A-II. An APPV CH-GX2016 strain was characterized from newly born piglets with clinical symptoms of congenital tremor in Guangxi, China. The genome of APPV CH-GX 2016 strain was 11,475 bp in length and encoded a polyprotein composed of the 3,635 amino acids. This genome sequence exhibited 88.0% to 90.8% nucleotide sequence homology with other APPV reference sequences in GenBank. Phylogenetic analysis further showed that APPV CH-GX is a novel pestivirus compared with previously described classical pestivirus strains...
February 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28628456/novel-pestivirus-species-in-pigs-austria-2015
#18
Benjamin Lamp, Lukas Schwarz, Sandra Högler, Christiane Riedel, Leonie Sinn, Barbara Rebel-Bauder, Herbert Weissenböck, Andrea Ladinig, Till Rümenapf
A novel pestivirus species was discovered in a piglet-producing farm in Austria during virologic examinations of congenital tremor cases. The emergence of this novel pestivirus species, provisionally termed Linda virus, in domestic pigs may have implications for classical swine fever virus surveillance and porcine health management.
July 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28553280/atypical-porcine-pestivirus-as-a-novel-type-of-pestivirus-in-pigs-in-china
#19
Jin Yuan, Zhiyong Han, Jun Li, Yunzhen Huang, Jiongfeng Yang, Hongxing Ding, Jingyuan Zhang, Mengjiao Zhu, Yangyi Zhang, Jiedan Liao, Mingqiu Zhao, Jinding Chen
Pestiviruses are highly variable RNA viruses. A growing number of novel pestiviruses has been discovered in domestic and wild species in the last two decades. Recently, a novel atypical porcine pestivirus (APPV) linked with the development of congenital tremor (CT) in neonatal pigs was described in Europe and the Americas. Here, the first Asian APPV complete polyprotein coding sequence was assembled from serum samples from newborn piglets affected with CT in Southern China, and termed APPV_GD. 14 organ samples from affected piglets were analyzed by quantitative RT-PCR (qRT-PCR) to investigate the tissue tropism of APPV, and 135 serum samples from pigs from 10 farms were used for identifying APPV in adult pigs...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28497656/identification-of-atypical-porcine-pestivirus-infection-in-swine-herds-in-china
#20
K Zhang, K Wu, J Liu, S Ge, Y Xiao, Y Shang, Z Ning
Atypical porcine pestivirus (APPV) have been detected in swine herds from the USA, Germany, the Netherlands, Spain and most recently in Austria, suggesting a wide geographic distribution of this novel virus. Here, for the first time, we reported APPV infection in swine herds in China. Newborn piglets from two separate swine herds in Guangdong province were found showing typical congenital tremors in July and August 2016. RT-PCR, sequencing and phylogenetic analysis showed APPV infection occurred. Phylogenetic analysis showed that Chinese APPV strains, GD1 and GD2, formed independent branch from the USA, Germany and the Netherlands...
May 11, 2017: Transboundary and Emerging Diseases
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