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https://www.readbyqxmd.com/read/30106875/minimum-quality-threshold-in-pre-clinical-sepsis-studies-mqtipss-an-international-expert-consensus-initiative-for-improvement-of-animal-modeling-in-sepsis
#1
Marcin F Osuchowski, Alfred Ayala, Soheyl Bahrami, Michael Bauer, Mihaly Boros, Jean-Marc Cavaillon, Irshad H Chaudry, Craig M Coopersmith, Clifford Deutschman, Susanne Drechsler, Philip Efron, Claes Frostell, Gerhard Fritsch, Waldemar Gozdzik, Judith Hellman, Markus Huber-Lang, Shigeaki Inoue, Sylvia Knapp, Andrey V Kozlov, Claude Libert, John C Marshall, Lyle L Moldawer, Peter Radermacher, Heinz Redl, Daniel G Remick, Mervyn Singer, Christoph Thiemermann, Ping Wang, W Joost Wiersinga, Xianzhong Xiao, Basilia Zingarelli
Pre-clinical animal studies precede the majority of clinical trials. While the clinical definitions of sepsis and recommended treatments are regularly updated, a systematic review of pre-clinical models of sepsis has not been done and clear modeling guidelines are lacking. To address this deficit, a Wiggers-Bernard Conference on pre-clinical sepsis modeling was held in Vienna in May, 2017. The goal of the conference was to identify limitations of pre-clinical sepsis models and to propose a set of guidelines, defined as the "Minimum Quality Threshold in Pre-Clinical Sepsis Studies" (MQTiPSS), to enhance translational value of these models...
August 14, 2018: Shock
https://www.readbyqxmd.com/read/30105433/minimum-quality-threshold-in-pre-clinical-sepsis-studies-mqtipss-an-international-expert-consensus-initiative-for-improvement-of-animal-modeling-in-sepsis
#2
REVIEW
Marcin F Osuchowski, Alfred Ayala, Soheyl Bahrami, Michael Bauer, Mihaly Boros, Jean-Marc Cavaillon, Irshad H Chaudry, Craig M Coopersmith, Clifford Deutschman, Susanne Drechsler, Philip Efron, Claes Frostell, Gerhard Fritsch, Waldemar Gozdzik, Judith Hellman, Markus Huber-Lang, Shigeaki Inoue, Sylvia Knapp, Andrey V Kozlov, Claude Libert, John C Marshall, Lyle L Moldawer, Peter Radermacher, Heinz Redl, Daniel G Remick, Mervyn Singer, Christoph Thiemermann, Ping Wang, W Joost Wiersinga, Xianzhong Xiao, Basilia Zingarelli
PURPOSE: Pre-clinical animal studies precede the majority of clinical trials. While the clinical sepsis definitions and recommended treatments are regularly updated, a systematic review of pre-clinical models of sepsis has not been done and clear modeling guidelines are lacking. To address this deficit, a Wiggers-Bernard Conference on pre-clinical sepsis modeling was held in Vienna in May, 2017. The conference goal was to identify limitations of pre-clinical sepsis models and to propose a set of guidelines, defined as the "Minimum Quality Threshold in Pre-Clinical Sepsis Studies" (MQTiPSS), to enhance translational value of these models...
August 14, 2018: Infection
https://www.readbyqxmd.com/read/30104615/pelvic-lymph-node-dissection-during-radical-cystectomy-for-muscle-invasive-bladder-cancer
#3
REVIEW
Marlon Perera, Shannon McGrath, Shomik Sengupta, Jack Crozier, Damien Bolton, Nathan Lawrentschuk
Radical cystectomy is the gold-standard treatment option for muscle-invasive and metastatic bladder cancer. At the time of cystectomy, up to 25% of patients harbour metastatic lymph node deposits. These deposits most frequently occur in the obturator fossa, but can be as proximal as the interaortocaval region. Thus, the use of concurrent pelvic lymph node dissection (PLND) with cystectomy has been increasingly reported. Data from studies including many patients suggest substantial oncological benefit in PLND cohorts versus non-PLND cohorts, irrespective of pathological nodal status...
August 13, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/30099633/neoadjuvant-therapy-for-breast-cancer-treatment-an-expert-panel-recommendation-from-the-brazilian-society-of-breast-surgeons-2018
#4
REVIEW
Fernanda Barbosa C Rocha, Ana Beatriz Falcone, Antonio Carlos Buzaid, Juliana Martins Pimenta, Gustavo Schvartsman, Antonio Luiz Frasson
PURPOSE: Breast cancer neoadjuvant chemotherapy (NAC) consists of the administration of cytotoxic and targeted drugs prior to breast surgery, with the objective of reducing the tumor burden to allow breast conservation. NAC also aims to improve long-term treatment outcomes such as disease-free and overall survival. To optimize clinical practice with the best available evidence for breast cancer patients in the setting of neoadjuvant treatment, the Brazilian Society of Breast Surgeons (Sociedade Brasileira de Mastologia-SBM) held a consensus conference to develop this guideline...
August 11, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/30093631/compatibility-of-runx1-eto-fusion-protein-modules-driving-cd34-human-progenitor-cell-expansion
#5
Linping Chen-Wichmann, Marina Shvartsman, Caro Preiss, Colin Hockings, Roland Windisch, Enric Redondo Monte, Georg Leubolt, Karsten Spiekermann, Jörn Lausen, Christian Brendel, Manuel Grez, Philipp A Greif, Christian Wichmann
Chromosomal translocations represent frequent events in leukemia. In t(8;21)+ acute myeloid leukemia, RUNX1 is fused to nearly the entire ETO protein, which contains four conserved nervy homology regions, NHR1-4. Furthermore RUNX1/ETO interacts with ETO-homologous proteins via NHR2, thereby multiplying NHR domain contacts. As shown recently, RUNX1/ETO retains oncogenic activity upon either deletion of the NHR3 + 4 N-CoR/SMRT interaction domain or substitution of the NHR2 tetramer domain. Thus, we aimed to clarify the specificities of the NHR domains...
August 9, 2018: Oncogene
https://www.readbyqxmd.com/read/30093514/development-of-a-simple-practice-based-tool-to-assess-quality-of-paediatric-emergency-care-delivery-in-resource-limited-settings-identifying-critical-actions-via-a-delphi-study
#6
Rajesh Kirit Daftary, Brittany Lee Murray, Teri Ann Reynolds
OBJECTIVE: Provision of timely, high-quality care for the initial management of critically ill children in African hospitals remains a challenge. Monitoring the completion of critical actions during resuscitations can inform efforts to reduce variability and improve outcomes. We sought to develop a practice-based tool based on contextually relevant actions identified via a Delphi process. Our goal was to develop a tool that could identify gaps in care, facilitate identification of training and standardised assessment to support quality improvement efforts...
August 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/30086278/current-practices-in-the-management-of-pulmonary-ground-glass-opacities-a-survey-of-sict-members
#7
Filippo Lococo, Giacomo Cusumano, Antonio Fabillian De Filippis, Giuseppe Curcurù, Rosatea Quercia, Giuseppe Marulli, Guglielmo Monaco, Pierluigi Granone, Giovanni Muriana, Federico Rea, Roberto Crisci, Gaetano Di Rienzo, Giuseppe Cardillo, Achille Lococo
BACKGROUND: Several gray areas and controversies exist concerning the management of pulmonary ground-glass opacities (GGOs) and there is a lack of consensus among clinicians on this topic. One of the main aims of the Italian Society of Thoracic Surgery (SICT) is to promote education and research, so we decided to perform a survey on this topic to estimate current trends in practice in a large sample of thoracic surgeons. METHODS: A total of 160 thoracic surgeons responded, i...
August 4, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/30082550/reporting-of-tumor-budding-in-colorectal-adenocarcinomas-using-%C3%A3-40-objective-a-practical-approach-for-resource-constrained-set-ups
#8
Paromita Roy, Jayati Datta, Manas Roy, Indranil Mallick, Mallath Mohandas
CONTEXT: Tumor budding (TBud) is recognized as a poor prognostic marker in colorectal cancer (CRC) with important treatment implications in Stage II cancers and malignant polyps. There are multiple propositions for bud count reporting but without an uniformly accepted system. The International TBud consensus conference (ITBCC) proposed mandatory reporting of budding on the single worst ×20 high power field (0.785 mm2 area) with a 3-tier scoring system (low/intermediate/high for 0-4, 5-9, and ≥10 buds/×20 field)...
October 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30082362/effectiveness-of-female-condom-in-preventing-hiv-and-sexually-transmitted-infections-a-systematic-review-protocol
#9
Ruth Kb Mome, Alison B Wiyeh, Eugene J Kongnyuy, Charles Shey Wiysonge
INTRODUCTION: The HIV pandemic continues to evolve with young women being the most vulnerable group to acquire infection. The presence of sexually transmitted infections (STIs) further enhances HIV susceptibility and also leads to long-term complications such as infertility and cervical cancer. The female condom is a self-initiated method for STI and HIV prevention but there are controversies on its effects. We aim to assess the effectiveness, safety and acceptability of the use of female condoms for prevention of STI and HIV acquisition among women...
August 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/30076767/validity-of-the-iwate-criteria-for-patients-with-hepatocellular-carcinoma-undergoing-minimally-invasive-liver-resection
#10
Felix Krenzien, Simon Wabitsch, Philipp Haber, Can Kamali, Philipp Brunnbauer, Christian Benzing, Georgi Atanasov, Go Wakabayashi, Robert Öllinger, Johann Pratschke, Moritz Schmelzle
BACKGROUND: Recently proposed by the International Consensus Conference on Laparoscopic Liver Resection, the Iwate criteria (IC) can be used by surgeons to predict the operative difficulty of laparoscopic liver resection (LLR) and were validated in patients with hepatocellular carcinoma (HCC), the most common indication for LLR. METHODS: The IC comprise six preoperative factors that allow the grading of operative difficulty as low, intermediate, advanced, or expert...
August 4, 2018: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/30074680/seeking-new-answers-to-old-questions-about-public-reporting-of-transplant-program-performance-in-the-united-states
#11
Bertram L Kasiske, Andrew Wey, Nicholas Salkowski, David Zaun, Cory R Schaffhausen, Ajay K Israni, Jon J Snyder
The Scientific Registry of Transplant Recipients (SRTR) is mandated by the National Organ Transplant Act, the Final Rule, and the SRTR contract with the Health Resources and Services Administration to report program-specific information on the performance of transplant programs. Following a consensus conference in 2012, SRTR developed a new version of the public website to improve public reporting of often complex metrics, including changing from a 3-tier to a 5-tier summary metric for first-year posttransplant survival...
August 3, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/30072142/results-of-the-modification-of-an-acute-pancreatitis-management-protocol-in-intensive-care-medicine
#12
L Amas Gómez, F Zubia Olaskoaga
OBJECTIVE: To determine whether the implementation of a protocol for the management of patients with acute pancreatitis (AP) in an Intensive Care Unit (ICU) improves the clinical outcomes. DESIGN: A retrospective, before-after observational case series study was carried out. STUDY PERIOD: 1 January 2001 to 31 December 2016, divided in 2 periods (pre-protocol 2001-2007, post-protocol 2008-2016). SCOPE: An ICU with 48 beds and a recruitment population of 700,000 inhabitants...
July 30, 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/30059723/current-status-and-future-development-of-infectious-cell-culture-models-for-the-major-genotypes-of-hepatitis-c-virus-essential-tools-in-testing-of-antivirals-and-emerging-vaccine-strategies
#13
REVIEW
Santseharay Ramirez, Jens Bukh
In this review, we summarize the relevant scientific advances that led to the development of infectious cell culture systems for hepatitis C virus (HCV) with the corresponding challenges and successes. We also provide an overview of how these systems have contributed to the study of antiviral compounds and their relevance for the development of a much-needed vaccine against this major human pathogen. An efficient infectious system to study HCV in vitro, using human hepatoma derived cells, has only been available since 2005, and was limited to a single isolate, named JFH1, until 2012...
July 27, 2018: Antiviral Research
https://www.readbyqxmd.com/read/30052961/recommendations-from-the-international-evidence-based-guideline-for-the-assessment-and-management-of-polycystic-ovary-syndrome
#14
Helena J Teede, Marie L Misso, Michael F Costello, Anuja Dokras, Joop Laven, Lisa Moran, Terhi Piltonen, Robert J Norman
STUDY QUESTION: What is the recommended assessment and management of women with polycystic ovary syndrome (PCOS), based on the best available evidence, clinical expertise and consumer preference? SUMMARY ANSWER: International evidence-based guidelines, including 166 recommendations and practice points, addressed prioritized questions to promote consistent, evidence-based care and improve the experience and health outcomes of women with PCOS. WHAT IS KNOWN ALREADY: Previous guidelines either lacked rigorous evidence-based processes, did not engage consumer and international multidisciplinary perspectives, or were outdated...
July 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/30052811/human-immunodeficiency-virus-drug-resistance-2018-recommendations-of-the-international-antiviral-society-usa-panel
#15
Huldrych F Günthard, Vincent Calvez, Roger Paredes, Deenan Pillay, Robert W Shafer, Annemarie M Wensing, Donna M Jacobsen, Douglas D Richman
Background: Contemporary antiretroviral therapies (ART) and management strategies have diminished both human immunodeficiency virus (HIV) treatment failure and the acquired resistance to drugs in resource-rich regions, but transmission of drug-resistant viruses has not similarly decreased. In low- and middle-income regions, ART roll-out has improved outcomes, but has resulted in increasing acquired and transmitted resistances. Our objective was to review resistance to ART drugs and methods to detect it, and to provide updated recommendations for testing and monitoring for drug resistance in HIV-infected individuals...
July 20, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30050156/a-consensus-statement-on-acromegaly-therapeutic-outcomes
#16
REVIEW
Shlomo Melmed, Marcello D Bronstein, Philippe Chanson, Anne Klibanski, Felipe F Casanueva, John A H Wass, Christian J Strasburger, Anton Luger, David R Clemmons, Andrea Giustina
The 11th Acromegaly Consensus Conference in April 2017 was convened to update recommendations on therapeutic outcomes for patients with acromegaly. Consensus guidelines on the medical management of acromegaly were last published in 2014; since then, new pharmacological agents have been developed and new approaches to treatment sequencing have been considered. Thirty-seven experts in the management of patients with acromegaly reviewed the current literature and assessed changes in drug approvals, clinical practice standards and clinical opinion...
July 26, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30043876/ivth-brazilian-consensus-conference-on-helicobacter-pylori-infection
#17
Luiz Gonzaga Vaz Coelho, James Ramalho Marinho, Robert Genta, Laercio Tenório Ribeiro, Maria do Carmo Friche Passos, Schlioma Zaterka, Paulo Pimentel Assumpção, Alfredo José A Barbosa, Ricardo Barbuti, Lucia Libanês Braga, Helenice Breyer, Aloisio Carvalhaes, Décio Chinzon, Marcelo Cury, Gerson Domingues, Jorge Luiz Jorge, Ismael Maguilnik, Frederico Passos Marinho, Joaquim Prado de Moraes-Filho, José Miguel Luz Parente, Celso Mirra de Paula-E-Silva, José Pedrazzoli-Júnior, Ana Flávia Passos Ramos, Heinrich Seidler, José Nonato Spinelli, José Vitor Zir
Significant progress has been obtained since the III Brazilian Consensus Conference on H. pylori infection held in 2012, in Bento Gonçalves, Brazil, and justify a fourth meeting to establish updated guidelines on the current management of H. pylori infection. Therefore, the Núcleo Brasileiro para Estudo do Helicobacter pylori e Microbiota (NBEHPM), association linked to Brazilian Federation of Gastroenterology (FBG) held its fourth meeting again in Bento Gonçalves, RS, Brazil, on August 25-27, 2017. Twenty-six delegates, including gastroenterologists, endoscopists, and pathologists from the five regions of Brazil as well as one international guest from the United States, participated in the meeting...
April 2018: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/30041262/management-of-spontaneous-pneumothorax-and-postinterventional-pneumothorax-german-s3-guideline
#18
Jost Schnell, Meinrad Beer, Stephan Eggeling, Wolfgang Gesierich, Jens Gottlieb, Felix Herth, Hans-Stefan Hofmann, Berthold Jany, Michael Kreuter, Julia Ley-Zaporozhan, Robert Scheubel, Thorsten Walles, Sebastian Wiesemann, Heinrich Worth, Erich Stoelben
In Germany, 10,000 cases of spontaneous pneumothorax are treated inpatient every year. The German Society for Thoracic Surgery (DGT), in co-operation with the German Society for Pulmonology (DGP), the German Radiological Society (DRG) and the German Society of Internal Medicine (DGIM) has developed an S3 guideline on spontaneous pneumothorax and postinterventional pneumothorax moderated by the German Association of Scientific Medical Societies (AWMF). METHOD: Based on the source guideline of the British Thoracic Society (BTS2010) for spontaneous pneumothorax, a literature search on spontaneous pneumothorax was carried out from 2008 onwards, for post-interventional pneumothorax from 1960 onwards...
July 24, 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/30041191/management-of-spontaneous-pneumothorax-and-post-interventional-pneumothorax-german-s3-guideline
#19
Jost Schnell, Meinrad Beer, Stephan Eggeling, Wolfgang Gesierich, Jens Gottlieb, Felix J F Herth, Hans-Stefan Hofmann, Berthold Jany, Michael Kreuter, Julia Ley-Zaporozhan, Robert Scheubel, Thorsten Walles, Sebastian Wiesemann, Heinrich Worth, Erich Stoelben
In Germany, 10,000 cases of spontaneous pneumothorax are treated inpatient every year. The German Society for Thoracic Surgery, in co-operation with the German Society for Pulmonology, the German Radiological Society, and the German Society of Internal Medicine has developed an S3 guideline on spontaneous pneumothorax and post-interventional pneumothorax moderated by the German Association of Scientific Medical Societies. METHOD: Based on the source guideline of the British Thoracic Society (2010) for spontaneous pneumothorax, a literature search on spontaneous pneumothorax was carried out from 2008 onwards, for post-interventional pneumothorax from 1960 onwards...
July 24, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/30040461/tumor-budding-in-colorectal-carcinoma-translating-a-morphologic-score-into-clinically-meaningful-results
#20
Soo-Jin Cho, Sanjay Kakar
CONTEXT: - Tumor budding has received increasing recognition as an important independent prognostic factor in colorectal carcinoma. Prominent tumor budding in adenocarcinoma arising in a polyp has been shown to be a risk factor for lymph node involvement. The variability in methods used for evaluating tumor budding in different studies and lack of standardized guidelines have impeded routine inclusion of tumor budding in pathology reports. This changed last year with consensus guidelines based on the International Tumor Budding Consensus Conference (ITBCC)...
August 2018: Archives of Pathology & Laboratory Medicine
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