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https://www.readbyqxmd.com/read/30335694/management-of-recurrent-and-de-novo-nafld-nash-after-liver-transplantation
#1
Giacomo Germani, Marie Laryea, Laura Rubbia-Brandt, Hiroto Egawa, Patrizia Burra, John O'Grady, Kymberly D Watt
Nonalcoholic steatohepatitis (NASH) is a growing indication for liver transplant whether the primary or secondary cause of liver disease, and it is expected to be the leading indication in the years to come. NASH recurs after transplant but the impact of the recurrence on allograft and patient outcomes is unclear. A group of multidisciplinary transplant practice providers convened at the International Liver Transplant Society NASH consensus conference with the purpose of determining the current knowledge and future directions for understanding the recurrence rates, risk and management of NASH in the transplant allograft...
October 17, 2018: Transplantation
https://www.readbyqxmd.com/read/30334577/newborn-screening-for-sickle-cell-disease-in-europe-recommendations-from-a-pan-european-consensus-conference
#2
Stephan Lobitz, Paul Telfer, Elena Cela, Bichr Allaf, Michael Angastiniotis, Carolina Backman Johansson, Catherine Badens, Celeste Bento, Marelle J Bouva, Duran Canatan, Matthew Charlton, Cathy Coppinger, Yvonne Daniel, Marianne de Montalembert, Patrick Ducoroy, Elena Dulin, Ralph Fingerhut, Claudia Frömmel, Marina García-Morin, Béatrice Gulbis, Ute Holtkamp, Baba Inusa, John James, Marina Kleanthous, Jeannette Klein, Joachim B Kunz, Lisa Langabeer, Claudine Lapouméroulie, Ana Marcao, José L Marín Soria, Corrina McMahon, Kwaku Ohene-Frempong, Jean-Marc Périni, Frédéric B Piel, Giovanna Russo, Laura Sainati, Markus Schmugge, Allison Streetly, Leon Tshilolo, Charles Turner, Donatella Venturelli, Laura Vilarinho, Rachel Yahyaoui, Jacques Elion, Raffaella Colombatti
Sickle Cell Disease (SCD) is an increasing global health problem and presents significant challenges to European health care systems. Newborn screening (NBS) for SCD enables early initiation of preventive measures and has contributed to a reduction in childhood mortality from SCD. Policies and methodologies for NBS vary in different countries, and this might have consequences for the quality of care and clinical outcomes for SCD across Europe. A two-day Pan-European consensus conference was held in Berlin in April 2017 in order to appraise the current status of NBS for SCD and to develop consensus-based statements on indications and methodology for NBS for SCD in Europe...
October 18, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30328198/proceedings-of-the-6th-iti-consensus-conference
#3
Daniel Wismeijer, Stephen T Chen
The 6th ITI Consensus Conference was held in Amsterdam on 17-19 April 2018. In preparation for the conference, 21 systematic reviews were written. They were divided into five main topics in dental implantology-surgery, prosthodontics, patient-reported outcomes, complications/risk and digital technologies. Based on these review papers, the working groups prepared consensus statements, clinical guidelines and recommendations for future research.
October 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/30328196/group-2-iti-consensus-report-prosthodontics-and-implant-dentistry
#4
Dean Morton, German Gallucci, Wei-Shao Lin, Bjarni Pjetursson, Waldemar Polido, Stefan Roehling, Irena Sailer, Tara Aghaloo, Hugo Albera, Lauren Bohner, Vedrana Braut, Daniel Buser, Stephen Chen, Anthony Dawson, Steven Eckert, Michael Gahlert, Adam Hamilton, Robert Jaffin, Christian Jarry, Banu Karayazgan, Juhani Laine, William Martin, Lira Rahman, Andreas Schlegel, Makato Shiota, Charlotte Stilwell, Christiaan Vorster, Anja Zembic, Wenjie Zhou
OBJECTIVES: Working Group 2 was convened to address topics relevant to prosthodontics and dental implants. Systematic reviews were developed according to focused questions addressing (a) the number of implants required to support fixed full-arch restorations, (b) the influence of intentionally tilted implants compared to axial positioned implants when supporting fixed dental prostheses (FDPs), (c) implant placement and loading protocols, (d) zirconia dental implants, (e) zirconia and metal ceramic implant supported single crowns and (f) zirconia and metal ceramic implant supported FDPs...
October 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/30328189/group-1-iti-consensus-report-the-influence-of-implant-length-and-design-and-medications-on-clinical-and-patient-reported-outcomes
#5
Ronald E Jung, Bilal Al-Nawas, Mauricio Araujo, Gustavo Avila-Ortiz, Stephen Barter, Nadine Brodala, Vivianne Chappuis, Bo Chen, Andre De Souza, Ricardo Faria Almeida, Stefan Fickl, Gary Finelle, Jeffrey Ganeles, Hadi Gholami, Christoph Hammerle, Simon Jensen, Asbjørn Jokstad, Hideaki Katsuyama, Johannes Kleinheinz, Chatchai Kunavisarut, Nikos Mardas, Alberto Monje, Panos Papaspyridakos, Michael Payer, Eik Schiegnitz, Ralf Smeets, Martina Stefanini, Christiaan Ten Bruggenkate, Konstantinos Vazouras, Hans-Peter Weber, Dieter Weingart, Péter Windisch
OBJECTIVES: The aim of Working Group 1 was to address the influence of different local (implant length, diameter, and design) and systemic (medications) factors on clinical, radiographic, and patient-reported outcomes in implant dentistry. Focused questions on (a) short posterior dental implants (≤6 mm), (b) narrow diameter implants, (c) implant design (tapered compared to a non-tapered implant design), and (d) medication-related dental implant failures were addressed. MATERIALS AND METHODS: Four systematic reviews were prepared in advance of the Consensus Conference and were discussed among the participants of Group 1...
October 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/30328187/group-3-iti-consensus-report-patient-reported-outcome-measures-associated-with-implant-dentistry
#6
Jocelyne Feine, Samir Abou-Ayash, Majd Al Mardini, Ronaldo Barcelllos de Santana, Trine Bjelke-Holtermann, Michael M Bornstein, Urs Braegger, Olivia Cao, Luca Cordaro, Didier Eycken, Mathieu Fillion, Georges Gebran, Guy Huynh-Ba, Tim Joda, Robert Levine, Nikos Mattheos, Thomas W Oates, Hani Abd-Ul-Salam, Robert Santosa, Shakeel Shahdad, Stefano Storelli, Nikitas Sykaras, Alejandro Treviño Santos, Ulrike Stephanie Webersberger, Mary Ann H Williams, Thomas G Wilson, Daniel Wismeijer, Julia-Gabriela Wittneben, Coral Jie Yao, Juan Pablo Villareal Zubiria
OBJECTIVES: The aim of Working Group 3 was to focus on three topics that were assessed using patient-reported outcome measures (PROMs). These topics included the following: (a) the aesthetics of tooth and implant-supported fixed dental prostheses focusing on partially edentulous patients, (b) a comparison of fixed and removable implant-retained prostheses for edentulous populations, and (c) immediate versus early/conventional loading of immediately placed implants in partially edentate patients...
October 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/30327406/protocol-for-a-multicentre-dual-prospective-and-retrospective-cohort-study-investigating-timing-of-ileostomy-closure-after-anterior-resection-for-rectal-cancer-the-closure-of-ileostomy-timing-close-it-study
#7
Peter G Vaughan-Shaw, Katherine Gash, Katie Adams, Abigail E Vallance, Sophie A Pilkington, Jared Torkington, Julie A Cornish
INTRODUCTION: A defunctioning ileostomy is often formed during rectal cancer surgery to reduce the potentially fatal sequelae of anastomotic leak. Once the ileostomy is closed and bowel continuity restored, many patients can suffer poor bowel function, that is, low anterior resection syndrome (LARS). It has been suggested that delay to closure can increase incidence of LARS which is known to significantly reduce quality of life. Despite this, within the UK, time to closure of ileostomy is not subject to national targets within the National Health Service and delay to closure exceeds 18 months in one-third of patients...
October 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/30325065/dataset-for-the-reporting-of-carcinoma-of-renal-tubular-origin-recommendations-from-the-international-collaboration-on-cancer-reporting-iccr
#8
REVIEW
B Delahunt, J R Srigley, M J Judge, M B Amin, A Billis, P Camparo, A J Evans, S Fleming, D Griffiths, A Lopez-Beltran, G Martignoni, H Moch, J N Nacey, M Zhou
AIMS: The International Collaboration on Cancer Reporting (ICCR) has provided detailed datasets based upon the published reporting protocols of the Royal College of Pathologists, The Royal College of Pathologists of Australasia and the College of American Pathologists. METHODS AND RESULTS: The dataset for carcinomas of renal tubular origin treated by nephrectomy was developed to provide a minimum structured reporting template suitable for international use and incorporated recommendations from the 2012 Vancouver Consensus Conference of the International Society of Urological Pathology and the fourth edition of the World Health Organization Bluebook on tumours of the urinary and male genital systems published in 2016...
October 16, 2018: Histopathology
https://www.readbyqxmd.com/read/30324047/gamification-of-hospital-utilization-incorporating-cost-consciousness-in-daily-practices
#9
Peter J Tomaselli, Dimitrios Papanagnou, Jonathan E Karademos, Elizabeth Teixeira, Xiao Chi Zhang
Healthcare costs in the United States have skyrocketed over the past decade, contributing to an estimated $750 billion in wasteful spending annually. Despite the demand to improve residency education on value-based, cost-conscious healthcare, there is no consensus on how to best teach this practice. Traditional lectures have failed to demonstrate enduring change in clinical practice patterns, provider attitudes, and reductions in hospital expenditures. We sought to evaluate whether gamification is an effective pedagogical tool to teach cost-consciousness to emergency medicine (EM) residents by creating a 60-minute interactive session based on the popular gameshow, the Price is Right...
August 3, 2018: Curēus
https://www.readbyqxmd.com/read/30318611/the-importance-of-ethics-in-dermatopathology-a-fellow-s-perspective
#10
I U Perkins
I am a second year dermatopathology fellow at the University of California San Francisco. As I begin my last year of training, I find myself increasingly considering questions that go beyond the usual "What is the most likely diagnosis or the most helpful immunostain?" Once I enter practice, what sort of pathologist, dermatopathologist, and physician colleague do I aspire to be? How will I do my best for the patient represented by each glass slide that crosses my stage? What should I do if I recognize that an error has been made, especially, if the error is my own? Very recently, we deliberated a particularly challenging case of a poorly differentiated malignant neoplasm in our division consensus conference; I wondered how much is truly "enough" in the work-up of such a case, particularly in an under-insured patient...
October 15, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/30314839/pathobiology-pathology-and-genetics-of-pulmonary-hypertension-update-from-the-cologne-consensus-conference-2018
#11
Andrea Olschewski, Eva M Berghausen, Christina A Eichstaedt, Bernd K Fleischmann, Ekkehard Grünig, Gabriele Grünig, Georg Hansmann, Lars Harbaum, Jan K Hennigs, Danny Jonigk, Wolfgang M Kuebler, Grazyna Kwapiszewska, Soni S Pullamsetti, Elvira Stacher, Norbert Weissmann, Daniela Wenzel, Ralph T Schermuly
The European guidelines, which focus on clinical aspects of pulmonary hypertension (PH), provide only minimal information about the pathophysiological concepts of PH. Here, we review this topic in greater detail, focusing on specific aspects in the pathobiology, pathology and genetics, which include mechanisms of vascular inflammation, the role of transcription factors, ion channels/ion channel diseases, hypoxic pulmonary vasoconstriction, genetics/epigenetics, metabolic dysfunction, and the potential future role of histopathology of PH in the modern era of PH therapy...
September 20, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30311387/clinvar-at-five-years-delivering-on-the-promise
#12
Melissa J Landrum, Brandi L Kattman
The increasing application of genetic testing for determining the causes underlying Mendelian, pharmacogenetic, and somatic phenotypes has accelerated the discovery of novel variants by clinical genetics laboratories, resulting in a critical need for interpreting the significance of these variants and presenting considerable challenges. Launched in 2013 at the National Center for Biotechnology Information, National Institutes of Health, ClinVar is a public database for clinical laboratories, researchers, expert panels, and others to share their interpretations of variants with their evidence...
November 2018: Human Mutation
https://www.readbyqxmd.com/read/30311285/2018-aem-consensus-conference-advancing-pem-education-through-research-scholarship
#13
Jean E Klig, Andrea Fang, Sean M Fox, Jeffrey Hom, Ashley Strobel, Sonny Tat, Jessica J Wall, Rahul Bhat, Eric Weinberg, Kurt R Deninghoff, Paul Ishmine, Maybelle Kou
Successful Pediatric Emergency Medicine (PEM) education research and scholarship can alter the varied landscape of care that is delivered outside of children's hospitals in the U.S. It is well established that most pediatric emergency care occurs in general emergency departments and urgent care centers by a diverse group of providers, whose core training and experience in treating acutely ill or injured children can be quite limited.1 Beyond gaps in fundamental PEM education, there are no systems, processes, or even standards that fully assure an ongoing communication of best practices between tertiary pediatric institutions and general (non-children's) hospital emergency departments...
October 12, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/30309991/burden-of-seasonal-influenza-in-sub-saharan-africa-a-systematic-review-protocol
#14
Evanson Zondani Sambala, Aaron Mdolo, Richard Banda, Arthur Phiri, Alison B Wiyeh, Charles Shey Wiysonge
INTRODUCTION: Measures of epidemiological burdens are an important contribution to estimating disease severity and determining the at-risk populations for seasonal influenza. In the absence of these data, it is extremely difficult for policy-makers to decide on how to distribute limited resources. This systematic review will synthesise the literature on reported burden of seasonal influenza (eg, morbidity and mortality) in sub-Saharan Africa. METHOD AND ANALYSIS: We will include published epidemiological studies that capture the burden estimation of seasonal influenza between 1 January 2000 and 31 August 2018...
October 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/30306699/dental-implant-quality-register-a-possible-tool-to-further-improve-implant-treatment-and-outcome
#15
Björn Klinge, Mats Lundström, Måns Rosén, Kristina Bertl, Anna Klinge, Andreas Stavropoulos
The Board of EAO (European Association for Osseointegration) has discussed an initiative to explore the conditions to establish a Dental Implant Register. It was suggested to bring this issue to the EAO Consensus Conference 2018 for a discussion and to possibly propose relevant and manageable parameters. This article presents some select examples from quality registers in the medical field. Based on the experience of established registers, essentially in the medical field, factors considered to be of importance, if and when establishing a Dental Implant Register are introduced and discussed...
October 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/30306692/dental-implant-register-summary-and-consensus-statements-of-group-2-the-5-th-eao-consensus-conference-2018
#16
Björn Klinge, Mariano Sanz, Gil Alcoforado, Stefan P Bienz, Jan Cosyn, Hugo De Bruyn, Jan Derks, Elena Figuero, Katarzyna Gurzawska, Lisa Heitz-Mayfield, Ronald E Jung, Turker Ornekul, Alberto Sagado
OBJECTIVES: This publication reports the EAO Workshop group-2 and consensus plenary discussions and statements on a narrative review providing the background and possible facilities and importance of a dental implant register, to allow for a systematic follow-up of the clinical outcome of dental implant treatment in various clinical settings. It should be observed that the format of the review and the subsequent consensus report consciously departs from conventional consensus publications and reports...
October 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/30306691/reconstructive-aspects-summary-and-consensus-statements-of-group-3-the-5-th-eao-consensus-conference-2018
#17
Irena Sailer, Sven Mühlemann, Ralf J Kohal, Benedikt C Spies, Bjarni E Pjetursson, Niklaus P Lang, Klaus L Gotfredsen, Jan E Ellingsen, Helena Francisco, Mutlu Özcan, Bassam Hassan, Guillem E Pardo, Javier A Bardaji, Riccardo D Kraus, Ann Wennerberg
OBJECTIVES: The tasks of this working group were to evaluate the existing evidence on the efficiency and efficacy of the digital and conventional workflows for the fabrication of fixed implant reconstructions, to assess the performance of all-ceramic fixed implant reconstructions and, finally, to evaluate the outcomes of internally and externally connected implant abutments and reconstructions. METHODS: Four reviews were available analyzing the current literature on the respective topics...
October 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/30306690/biomechanical-aspects-summary-and-consensus-statements-of-group-4-the-5-th-eao-consensus-conference-2018
#18
Christoph H F Hämmerle, Luca Cordaro, Karol A Apaza Alccayhuaman, Daniele Botticelli, Marco Esposito, Lino E Colomina, Alfonso Gil, Felix L Gulje, Alexis Ioannidis, Henny Meijer, Spyridon Papageorgiou, Gerry Raghoebar, Eugenio Romeo, Franck Renouard, Stefano Storelli, Ferruccio Torsello, Hannes Wachtel
OBJECTIVES: The aim of the present publication was to report on the EAO Workshop group-4 discussions and consensus statements on the five reviews previously prepared. These reviews provided the scientific evidence on the effect of crown-to-implant ratio, on reconstructions with cantilevers in fully and partially edentulous patients, on biological and technical complications of tilted in comparison with straight implants, and on the effects of osseointegrated implants functioning in a residual dentition...
October 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/30306688/the-5-th-eao-consensus-conference-7-10-february-2018-pf%C3%A3-ffikon-schwyz-switzerland
#19
Christoph H F Hämmerle, Björn Klinge, Henning Schliephake
No abstract text is available yet for this article.
October 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/30306685/biological-aspects-summary-and-consensus-statements-of-group-2-the-5-th-eao-consensus-conference-2018
#20
Mariano Sanz, Bjorn Klinge, Gil Alcoforado, Stefan P Bienz, Jan Cosyn, Hugo De Bruyn, Jan Derks, Elena Figuero, Katarzyna Gurzawska, Lisa Heitz-Mayfield, Ronald E Jung, Tunker Ornekul, Alberto Sagado
OBJECTIVES: This publication reports the EAO Workshop group-2 discussions and consensus statements which provided the scientific evidence on the influence of biological parameters on implant-related clinical outcomes. MATERIAL AND METHODS: The first publication was a systematic review on the biological effects of abutment material on the stability of peri-implant marginal bone levels and the second, a critical narrative review on how peri-implant diagnostic parameters correspond with long-term implant survival and success...
October 2018: Clinical Oral Implants Research
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