Read by QxMD icon Read

Early Initiation

Hongbo Ling, Lirong Peng, Jianbo Wang, Raneen Rahhal, Edward Seto
The protein deacetylase SIRT1 (Sirtuin 1) regulates many cellular processes, including cell-cycle progression, DNA damage response, and metabolism. Although the centrosome is a key regulator of cell-cycle progression and genome stability, little is known concerning SIRT1 controlled centrosome-associated events. Here we report that the centrosome protein Plk2 is acetylated and undergoes deacetylation by SIRT1. Acetylation protects Plk2 from ubiquitination, and SIRT1-mediated deacetylation promotes ubiquitin-dependent degradation of Plk2...
December 4, 2018: Cell Reports
Andreia M Gomes, Ilia Kurochkin, Betty Chang, Michael Daniel, Kenneth Law, Namita Satija, Alexander Lachmann, Zichen Wang, Lino Ferreira, Avi Ma'ayan, Benjamin K Chen, Dmitri Papatsenko, Ihor R Lemischka, Kateri A Moore, Carlos-Filipe Pereira
During development, hematopoietic stem and progenitor cells (HSPCs) arise from specialized endothelial cells by a process termed endothelial-to-hematopoietic transition (EHT). The genetic program driving human HSPC emergence remains largely unknown. We previously reported that the generation of hemogenic precursor cells from mouse fibroblasts recapitulates developmental hematopoiesis. Here, we demonstrate that human fibroblasts can be reprogrammed into hemogenic cells by the same transcription factors. Induced cells display dynamic EHT transcriptional programs, generate hematopoietic progeny, possess HSPC cell surface phenotype, and repopulate immunodeficient mice for 3 months...
December 4, 2018: Cell Reports
Can Ozlu, Gul Yesiltepe Mutlu, Sukru Hatun
Background H syndrome ([OMIM] 602782) is an autosomal recessive disorder with systemic manifestations and characteristic skin lesions, caused by mutations of the SLC29A3 gene. Short stature and diabetes mellitus are the major endocrine problems related to H syndrome, however, clear data from clinical follow-up of H syndrome patients is lacking in the literature. Case presentation Here, we present follow-up of a Turkish girl diagnosed with H syndrome at the age of 10 with a homozygous 310(c.933T>A, p.C310X) early stop codon mutation on exon 6 of the SLC29A3 gene...
December 5, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Jerry K Y Chan, Irene Gil-Farina, Nuryanti Johana, Cecilia Rosales, Yi Wan Tan, Jessika Ceiler, Jenny Mcintosh, Bryan Ogden, Simon N Waddington, Manfred Schmidt, Arijit Biswas, Mahesh Choolani, Amit C Nathwani, Citra N Z Mattar
Adeno-associated viral vectors (AAVs) achieve stable therapeutic expression without long-term toxicity in adults with hemophilia. To avert irreversible complications in congenital disorders producing early pathogenesis, safety and efficacy of AAV-intrauterine gene transfer (IUGT) requires assessment. We therefore performed IUGT of AAV5 or -8 with liver-specific promoter-1 encoding either human coagulation factors IX (hFIX) or X (hFX) into Macaca fascicularis fetuses at ∼0.4 gestation. The initial cohort received 1 × 1012 vector genomes (vgs) of AAV5-hFIX ( n = 5; 0...
December 5, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Moritz Binder, S Vincent Rajkumar, Martha Q Lacy, Morie A Gertz, Francis K Buadi, Angela Dispenzieri, Lisa Hwa, Amie Fonder, Miriam Hobbs, Suzanne R Hayman, Steven R Zeldenrust, John A Lust, Stephen J Russell, Nelson Leung, Prashant Kapoor, Ronald S Go, Wilson I Gonsalves, Taxiarchis Kourelis, Rahma Warsame, Robert A Kyle, Shaji K Kumar
Peripheral blood biomarkers of tumor microenvironment and immune surveillance are independent prognostic factors in multiple myeloma. The timing and prognostic impact of immune reconstitution has been studied after autologous hematopoietic stem cell transplantation, less is known about its significance in newly diagnosed multiple myeloma. We studied absolute lymphocyte (ALC) and monocyte (AMC) counts at the time of treatment initiation and one month thereafter in 771 newly diagnosed patients. Two hundred and thirty-four patients (31%) had evidence of immune dysregulation at baseline (abnormal biomarkers)...
December 5, 2018: American Journal of Hematology
Nora D Volkow, Emily B Jones, Emily B Einstein, Eric M Wargo
Importance: More than 42 000 Americans died of opioid overdoses in 2016, and the fatalities continue to increase. This review analyzes the factors that triggered the opioid crisis and its further evolution, along with the interventions to manage and prevent opioid use disorder (OUD), which are fundamental for curtailing the opioid crisis. Observations: Opioid drugs are among the most powerful analgesics but also among the most addictive. The current opioid crisis, initially triggered by overprescription of opioid analgesics, which facilitated their diversion and misuse, has now expanded to heroin and illicit synthetic opioids (fentanyl and its analogues), the potency of which further increases their addictiveness and lethality...
December 5, 2018: JAMA Psychiatry
Chethan P Venkatasubba Rao, Jose I Suarez
PURPOSE OF REVIEW: This article provides updated information regarding the diagnosis and treatment (specifically critical care management) of acute ischemic stroke. This article also discusses the increased use of thrombolysis and thrombectomy in clinical practice. RECENT FINDINGS: Stroke is the leading cause of disability in the United States. A significant proportion of patients with acute ischemic stroke require critical care management. Much has changed in the early evaluation and treatment of patients presenting with acute ischemic stroke...
December 2018: Continuum: Lifelong Learning in Neurology
Matthieu Schmidt, Guillaume Franchineau, Alain Combes
PURPOSE OF REVIEW: To summarize results of the most recent trials on venovenous extracorporeal membrane oxygenation (VV-ECMO) in severe acute respiratory distress syndrome (ARDS) and to elaborate on the unmet needs regarding VV-ECMO management in this setting. RECENT FINDINGS: Although it was terminated early for futility (i.e., failure to demonstrate a difference in 60-day mortality of 20%), the ECMO to Rescue Lung Injury in Severe ARDS trial of VV-ECMO for severe ARDS reported a nonsignificant, but clinically important, reduction in mortality (35 vs...
November 30, 2018: Current Opinion in Critical Care
Ching-Yu Lan, Huey-Yuan Tien, Yu-Te Lin, Chun-Cheng Hsu, Cheng-Hung Lin, Shih-Heng Chen
Ulnar nerve injury (UNI) is not uncommon and often results in incomplete motor recovery after the initial nerve repair and requires secondary functional reconstruction. To clarify the prognosis and predicting factor of UNI, and if it is reasonable to wait after the initial repair, a systematic literature review from PubMed computerized literature database and Google scholar was performed. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist and guidelines were followed to develop the search protocol for this literature review...
November 30, 2018: Annals of Plastic Surgery
Mahesh Sarki, Alexandr Parlesak, Aileen Robertson
OBJECTIVE: Breast-feeding is an important determinant of health of mothers and their offspring. The present study aimed to compare breast-feeding rates across Europe disaggregated by maternal education and establish what proportion achieves at least 50 % exclusive breast-feeding (EBF) at 6 months.Design/SettingSecondary analysis of national or sub-national studies' breast-feeding data for EU Member States plus Norway and Iceland, published in 2006-2016. Nineteen EU Member States plus Norway reported rates of EBF and any breast-feeding disaggregated by maternal education, of which only thirteen could be matched to the International Standard Classification of Education...
December 5, 2018: Public Health Nutrition
Noreen Kamal, Elaine Shand, Robert Swanson, Michael D Hill, Thomas Jeerakathil, Oje Imoukhuede, Irvin Heinrichs, Jackie Bakker, Carol Stoyberg, Laura Fowler, Sandy Duckett, Scott Holsworth, Balraj Mann, Shelley Valaire, Jennifer Bestard
BACKGROUND: Alteplase is an effective treatment for ischaemic stroke patients, and it is widely available at all primary stroke centres. The effectiveness of alteplase is highly time-dependent. Large tertiary centres have reported significant improvements in their door-to-needle (DTN) times. However, these same improvements have not been reported at community hospitals. METHODS: Red Deer Regional Hospital Centre (RDRHC) is a community hospital of 370 beds that serves approximately 150,000 people in their acute stroke catchment area...
December 5, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
Iñigo Ojanguren, Ferran Morell, María-Antonia Ramón, Ana Villar, Christian Romero, María-Jesús Cruz, Xavier Muñoz
INTRODUCTION: The objective of this study was to analyze mortality, possible predictors of long-term survival and health-related quality of life of a large chronic hypersensitivity pneumonitis (CHP) patient sample. METHODS: Longitudinal study in patients diagnosed with CHP during 2004-2013, followed for at least one year. Patients remaining alive and consenting to participate had a follow-up visit during 2015, including a complete pulmonary function study and the EuroQol-5D and Beck Depression and Anxiety Inventories...
December 4, 2018: Allergy
Rajab Mardani, Mohammad Hassan Jafari Najaf Abadi, Mahsa Motieian, Sima Taghizadeh-Boroujeni, Amir Bayat, Alireza Farsinezhad, Seyed Mohammad Gheibi Hayat, Mahtab Motieian, Hossein Pourghadamyari
Leukemia is known as a progressive malignant disease, which destroys the blood-forming organs and results in adverse effects on the proliferation and development of leukocytes and their precursors in the blood and bone marrow. There are four main classes of leukemia including acute leukemia, chronic leukemia, myelogenous leukemia, and lymphocytic leukemia. Given that a variety of internal and external factors could be associated with the initiation and progression of different types of leukemia. One of the important factors is epigenetic regulators such as microRNAs (miRNAs) and long noncoding RNAs (ncRNA)...
December 4, 2018: Journal of Cellular Physiology
Sine Ravn Havmoeller, Per H Thomsen, Sanne Lemcke
Although there is limited knowledge about early signs of ADHD, deviations in motor development are suggested as a possible indicator of such early signs. The purpose of the present systematic review was to gather knowledge about motor development before three years of age in children later diagnosed with ADHD. A systematic search was completed in four research databases, and the quality of the identified studies was systematically assessed. Of 440 initial search results, only five studies met the inclusion criteria and were fully abstracted...
December 4, 2018: Attention Deficit and Hyperactivity Disorders
Andreas Johnen, Paul-Christian Bürkner, Nils C Landmeyer, Björn Ambrosius, Pasquale Calabrese, Jeremias Motte, Nicole Hessler, Gisela Antony, Inke R König, Luisa Klotz, Muna-Miriam Hoshi, Lilian Aly, Sergiu Groppa, Felix Luessi, Friedemann Paul, Björn Tackenberg, Florian Then Bergh, Tania Kümpfel, Hayrettin Tumani, Martin Stangel, Frank Weber, Antonios Bayas, Brigitte Wildemann, Christoph Heesen, Uwe K Zettl, Frauke Zipp, Bernhard Hemmer, Sven G Meuth, Ralf Gold, Heinz Wiendl, Anke Salmen
BACKGROUND: Cognitive impairment (CI) affects approximately one-third of the patients with early multiple sclerosis (MS) and clinically isolated syndrome (CIS). Little is known about factors predicting CI and progression after initial diagnosis. METHODS: Neuropsychological screening data from baseline and 1-year follow-up of a prospective multicenter cohort study (NationMS) involving 1123 patients with newly diagnosed MS or CIS were analyzed. Employing linear multilevel models, we investigated whether demographic, clinical and conventional MRI markers at baseline were predictive for CI and longitudinal cognitive changes...
December 4, 2018: Journal of Neurology
Stephanie N Moore-Lotridge, Qiaoli Li, Breanne H Y Gibson, Joseph T Martin, Gregory D Hawley, Thomas H Arnold, Masanori Saito, Sami Tannouri, Herbert S Schwartz, Richard J Gumina, Justin M M Cates, Jouni Uitto, Jonathan G Schoenecker
Heterotopic ossification (HO), or the pathologic formation of bone within soft tissues, is a significant complication following severe injuries as it impairs joint motion and function leading to loss of the ability to perform activities of daily living and pain. While soft tissue injury is a prerequisite of developing HO, the exact molecular pathology leading to trauma-induced HO remains unknown. Through prior investigations aimed at identifying the causative factors of HO, it has been suggested that additional predisposing factors that favor ossification within the injured soft tissues environment are required...
December 4, 2018: Calcified Tissue International
Corinna Trujillo Tanner, Michael S Caserta, Julia J Kleinschmidt, Margaret S Clayton, Paul S Bernstein, Jia Wen Guo
Older adults are underrepresented in research, and a potential barrier to their participation may be the increasing prevalence of vision loss and lack of accommodation for this challenge. Although vision loss may initially pose a challenge to research participation, its effects can be mitigated with early, in-depth planning. For example, recruitment is more inclusive when best practices identified in the literature are used in the preparation of written materials to reduce glare and improve readability and legibility...
January 2018: Gerontology & Geriatric Medicine
Sona Haku, Hiromichi Wakui, Kengo Azushima, Kotaro Haruhara, Sho Kinguchi, Kohji Ohki, Kazushi Uneda, Ryu Kobayashi, Miyuki Matsuda, Takahiro Yamaji, Takayuki Yamada, Shintaro Minegishi, Tomoaki Ishigami, Akio Yamashita, Kenichi Ohashi, Kouichi Tamura
Abnormal angiogenesis plays a major role in the development of early stage diabetic nephropathy. Vascular endothelial growth factor (VEGF) is a classical proangiogenic factor that regulates abnormal glomerular angiogenesis linked to glomerular hypertrophy in the early stage of diabetic nephropathy. Leucine-rich α -2-glycoprotein-1 (LRG1) was recently reported as a novel proangiogenic factor that is expressed in endothelial cells and promotes angiogenesis by modulating the transforming growth factor- β signaling pathway...
2018: BioMed Research International
Erik W J Mollen, Jonathan Ient, Vivianne C G Tjan-Heijnen, Liesbeth J Boersma, Lucio Miele, Marjolein L Smidt, Marc A G G Vooijs
Breast cancer is the second most common malignancy, worldwide. Treatment decisions are based on tumor stage, histological subtype, and receptor expression and include combinations of surgery, radiotherapy, and systemic treatment. These, together with earlier diagnosis, have resulted in increased survival. However, initial treatment efficacy cannot be guaranteed upfront, and these treatments may come with (long-term) serious adverse effects, negatively affecting a patient's quality of life. Gene expression-based tests can accurately estimate the risk of recurrence in early stage breast cancers...
2018: Frontiers in Oncology
Chance Taylor Pistoll, Steven Cummins
This study aims to explore changes in uptake and cessation of walking, cycling and public transport use across the lifespan in a representative sample of UK adults aged 16 and older. A longitudinal analysis of 11,559 individuals in waves two (2010-2012) and six (2014-2016) of the General Population Sample (GPS) of the UK Household Longitudinal Survey (UKHLS) was performed. The outcome variables were self-reported and categorised as changes to and from 1) walking or cycling and 2) public transport. In adjusted models compared to younger adults (aged 16-34), middle-aged adults (aged 45-55: OR 0...
March 2019: Preventive Medicine Reports
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"