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Graphene apoptosis

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https://www.readbyqxmd.com/read/28092742/short-term-in-vivo-exposure-to-graphene-oxide-can-cause-damage-to-the-gut-and-testis
#1
Marta Dziewięcka, Julia Karpeta-Kaczmarek, Maria Augustyniak, Magdalena Rost-Roszkowska
Graphene oxide (GO) has unique physicochemical properties and also has a potentially widespread use in every field of daily life (industry, science, medicine). Demand for nanotechnology is growing every year, and therefore many aspects of its toxicity and biocompatibility still require further clarification. This research assesses the in vivo toxicity of pure and manganese ion-contaminated GO that were administrated to Acheta domesticus with food (at 200mgkg(-1) of food) throughout their ten-day adult life...
January 9, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28088076/in%C3%A2-vivo-visualization-of-endogenous-mir-21-using-hyaluronic-acid-coated-graphene-oxide-for-targeted-cancer-therapy
#2
Do Won Hwang, Han Young Kim, Fangyuan Li, Ji Yong Park, Dohyun Kim, Jae Hyung Park, Hwa Seung Han, Jung Woo Byun, Yun-Sang Lee, Jae Min Jeong, Kookheon Char, Dong Soo Lee
Oncogene-targeted nucleic acid therapy has been spotlighted as a new paradigm for cancer therapeutics. However, in vivo delivery issues and uncertainty of therapeutic antisense drug reactions remain critical hurdles for a successful targeted cancer therapy. In this study, we developed a fluorescence-switchable theranostic nanoplatform using hyaluronic acid (HA)-conjugated graphene oxide (GO), which is capable of both sensing oncogenic miR-21 and inhibiting its tumorigenicity simultaneously. Cy3-labeled antisense miR-21 peptide nucleic acid (PNA) probes loaded onto HA-GO (HGP21) specifically targeted CD44-positive MBA-MB231 cells and showed fluorescence recovery by interacting with endogenous miR-21 in the cytoplasm of the MBA-MB231 cells...
December 31, 2016: Biomaterials
https://www.readbyqxmd.com/read/28079217/cisplatin-induced-self-assembly-of-graphene-oxide-sheets-into-spherical-nanoparticles-for-damaging-sub-cellular-dna
#3
Aditi Nandi, Abhik Mallick, Piyush More, Poulomi Sengupta, Nirmalya Ballav, Sudipta Basu
This report describes the hitherto unobserved cisplatin induced self-assembly of 2D-graphene oxide sheets into 3D-spherical nano-scale particles. These nanoparticles can encompass dual DNA damaging drugs simultaneously. A combination of confocal microscopy, gel electrophoresis and flow cytometry studies clearly demonstrated that these novel nanoparticles can internalize into cancer cells by endocytosis, localize into lysosomes, and damage DNA, leading to apoptosis. Cell viability assays indicated that these nanoparticles were more cytotoxic towards cancer cells compared to healthy cells...
January 12, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28042941/ph-responsive-self-sacrificial-nanotheranostic-agent-for-potential-in-vivo-and-in-vitro-dual-modal-mri-ct-imaging-real-time-and-in-situ-monitoring-of-cancer-therapy
#4
Ludan Yue, Jinlong Wang, Zhichao Dai, Zunfu Hu, Xue Chen, Yafei Qi, Xiuwen Zheng, Dexin Yu
Multifunctional nanotheranostic agents have been highly commended due to the application to image-guided cancer therapy. Herein, based on the chemically disordered face centered cubic (fcc) FePt nanoparticles (NPs) and graphene oxide (GO), we develop a pH-responsive FePt-based multifunctional theranostic agent for potential in vivo and in vitro dual modal MRI/CT imaging and in situ cancer inhibition. The fcc-FePt will release highly active Fe ions due to the low pH in tumor cells, which would catalyze H2O2 decomposition into reactive oxygen species (ROS) within the cells and further induce cancer cell apoptosis...
January 20, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28013165/in-vitro-cytotoxicity-evaluation-of-graphene-oxide-from-the-peroxidase-like-activity-perspective
#5
Wei Zhang, Ying Sun, Zhichao Lou, Lina Song, Yang Wu, Ning Gu, Yu Zhang
In this study, PEGylated graphene oxide (PEG-GO)-hemin composite structure was constructed. Hemin in the form of nanoscaled aggregates were immobilized on PEG-GO sheets by the π-π stacking super-molecular interaction. Via catalyzing the oxidation of chromogenic substrates, we elicited the obtained PEG-GO-Hemin composite sheets have much higher peroxidase-like activity compared to hemin or PEG-GO alone, which is due to the introduction of enzyme active center of hemin with high dispersity, the excellent affinity to organic substrate through π-π stacking and/or electrostatic adsorption and the rapid electron transfer capability of PEG-GO...
December 19, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28005089/-fullerenols-in-therapy-and-diagnosis-of-cancer
#6
REVIEW
Anna Lichota, Anita Krokosz
Malignant tumors are one of the main causes of death in Poland. One of the objectives of contemporary biomedical research is to maximize the effects of therapeutic strategies. The actions undertaken to improve therapeutic agents are aimed at reducing the side effects of cancer treatments. Another direction of investigations is the search for protective substances that reduce the toxicity of the drug to normal cells. Carbon-based nanomaterials (fullerenes and their derivatives, graphene, carbon nanotubes, nanodiamonds) are a broad class of nanoparticles that have potential biomedical applications in both therapy and diagnostics...
December 22, 2016: Medycyna Pracy
https://www.readbyqxmd.com/read/27987732/apoptotic-and-anti-apoptotic-genes-transcripts-patterns-of-graphene-in-mice
#7
Hossein Ahmadian, Ehsan Hashemi, Omid Akhavan, Mehdi Shamsara, Mehrdad Hashemi, Abbas Farmany, Morteza Daliri Joupari
Recent studies showed that a large amount of graphene oxide accumulated in kidney and liver when it injected intravenously. Evaluation of lethal and apoptosis gene expression in these tissues, which are under stress is very important. In this paper the in vivo dose-dependent effects of graphene oxide and reduced graphene oxide nanoplatelets on kidney and liver of mice were studied. Balb/C mice were treated by 20mg/kg body weight of nanoplatelets. Molecular biology analysis showed that graphene nanoplatelets injected intravenously lead to overexpression of BAX gene in both kidney and liver tissues (P≥0...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27941848/in-vitro-and-in-vivo-comparison-of-the-immunotoxicity-of-single-and-multi-layered-graphene-oxides-with-or-without-pluronic-f-127
#8
Young Chol Cho, Pyo June Pak, Yong Hoon Joo, Hoi-Seon Lee, Namhyun Chung
Graphene oxide (GO) has been a focus of research in the fields of electronics, energy, and biomedicine, including drug delivery. Thus, single- and multi-layered GO (SLGO and MLGO) have been produced and investigated. However, little information on their toxicity and biocompatibility is available. In the present study, we performed a comprehensive study of the size- and dose-dependent toxicity of GOs in the presence or absence of Pluronic F-127 on THP-1 cells by examining their viability, membrane integrity, levels of cytokine and ROS production, phagocytosis, and cytometric apoptosis...
December 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27853677/reduced-graphene-oxide-decorated-with-gold-nanoparticle-as-signal-amplification-element-on-ultra-sensitive-electrochemiluminescence-determination-of-caspase-3-activity-and-apoptosis-using-peptide-based-biosensor
#9
Balal Khalilzadeh, Nasrin Shadjou, Hadi Afsharan, Morteza Eskandani, Hojjatollah Nozad Charoudeh, Mohammad-Reza Rashidi
Introduction: Growing demands for ultrasensitive biosensing have led to the development of numerous signal amplification strategies. In this report, a novel electrochemiluminescence (ECL) method was developed for the detection and determination of caspase-3 activity based on reduced graphene oxide sheets decorated by gold nanoparticles as signal amplification element and horseradish peroxidase enzyme (HRP) as ECL intensity enhancing agent. Methods: The ECL intensity of the luminol was improved by using the streptavidin coated magnetic beads and HRP in the presence of hydrogen peroxide...
2016: BioImpacts: BI
https://www.readbyqxmd.com/read/27825531/preliminary-study-on-an-innovative-simple-mast-cell-based-electrochemical-method-for-detecting-foodborne-pathogenic-bacterial-quorum-signaling-molecules-n-acyl-homoserine-lactones
#10
Donglei Jiang, Dongdong Feng, Hui Jiang, Limin Yuan, Yin Yongqi, Xin Xu, Weiming Fang
This paper reports the a novel and simple mast cell-based electrochemical method for detecting of bacterial quorum signaling molecules, N-acylhomoserine lactones (AHLs), which can be utilized to preliminarily evaluate the toxicity of food-borne pathogenic bacteria. Rat basophilic leukemia (RBL-2H3) mast cells encapsulated in alginate/graphene oxide hydrogel were immobilized on a gold electrode, while mast cells as recognition elements were cultured in a 3D cell culture system. Electrochemical impedance spectroscopy (EIS) was utilized to record the cell impedance signal as-influenced by Pseudomonas aeruginosa quorum-sensing molecule, N-3-oxododecanoyl homoserine lactone (3OC12-HSL)...
April 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27799056/toxicity-of-graphene-family-nanoparticles-a-general-review-of-the-origins-and-mechanisms
#11
REVIEW
Lingling Ou, Bin Song, Huimin Liang, Jia Liu, Xiaoli Feng, Bin Deng, Ting Sun, Longquan Shao
Due to their unique physicochemical properties, graphene-family nanomaterials (GFNs) are widely used in many fields, especially in biomedical applications. Currently, many studies have investigated the biocompatibility and toxicity of GFNs in vivo and in intro. Generally, GFNs may exert different degrees of toxicity in animals or cell models by following with different administration routes and penetrating through physiological barriers, subsequently being distributed in tissues or located in cells, eventually being excreted out of the bodies...
October 31, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27786282/cristae-remodeling-causes-acidification-detected-by-integrated-graphene-sensor-during-mitochondrial-outer-membrane-permeabilization
#12
Ted D Pham, Phi Q Pham, Jinfeng Li, Anthony G Letai, Douglas C Wallace, Peter J Burke
The intrinsic apoptotic pathway and the resultant mitochondrial outer membrane permeabilization (MOMP) via BAK and BAX oligomerization, cytochrome c (cytc) release, and caspase activation are well studied, but their effect on cytosolic pH is poorly understood. Using isolated mitochondria, we show that MOMP results in acidification of the surrounding medium. BAK conformational changes associated with MOMP activate the OMA1 protease to cleave OPA1 resulting in remodeling of the cristae and release of the highly concentrated protons within the cristae invaginations...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27721039/-gold-nanoparticles-composite-folic-acid-conjugated-graphene-oxide-nanohybrids-for-targeted-chemo-thermal-cancer-ablation-in-vitro-screening-and-in-vivo-studies
#13
Gaurav Chauhan, Vianni Chopra, Amit Tyagi, Goutam Rath, Rakesh K Sharma, Amit K Goyal
Nano-graphene oxide (GO) nanometal composite (specifically nanogold and nanosilver) have shown to be a promising material for anticancer therapeutics. Owing to their high drug loading capacity, photothermal and synergizing effects, it is very important to exploit them for targeted chemo-thermal cancer therapeutics. In this work, gold nanoparticles (AuNPs) were selected as the composite metal, folic acid (FA) was taken as GO surface functionalization moiety for active tumor targeting of model anticancer drug Doxorubicin (Dox)...
January 1, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27684494/triggering-of-apoptosis-in-osteosarcoma-cells-by-graphene-single-walled-carbon-nanotube-hybrids-via-the-ros-mediated-mitochondrial-pathway
#14
Xinxin Yan, Wen Yang, Zengwu Shao, Shuhua Yang, Xianzhe Liu
Carbon nanomaterials are increasingly significant in the biological and medical fields, especially becoming promising candidates in treating difficult and complicated disease. Graphene/single-walled carbon nanotubes (G/SWCNT) hybrids is 3D structure which has been constructed by combining 1D single-walled carbon nanotubes (SWCNTs) and 2D graphene. However, the effects of the nanomaterial on biological systems are limited. In this study, we report a systematic investigation of the cytotoxicity and in vivo biodistribution of G/SWCNT hybrids on osteosarcoma cells (HOS and U2OS)...
February 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27647388/effect-of-graphene-oxide-on-bacteria-and-peripheral-blood-mononuclear-cells
#15
Jessica Campos-Delgado, Kelly L S Castro, Jose G Munguia-Lopez, Ana K González, Martin E Mendoza, Benjamin Fragneaud, Raphael Verdan, Joyce R Araujo, Francisco J González, Hugo Navarro-Contreras, Ivan N Pérez-Maldonado, Antonio de León-Rodríguez, Carlos A Achete
BACKGROUND: Driven by the potential biological applications of graphene, many groups have studied the response of cells exposed to graphene oxide (GO). In particular, investigations of bacteria indicate that there are 2 crucial parameters, which so far have only been investigated separately: GO size and exposure methodology. Our study took into account both parameters. We carefully characterized the samples to catalog sizes and structural properties, and tested different exposure methodologies: exposure in saline solution and in the presence of growth media...
November 2, 2016: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/27640918/graphene-oxide-induces-apoptotic-cell-death-in-endothelial-cells-by-activating-autophagy-via-calcium-dependent-phosphorylation-of-c-jun-n-terminal-kinases
#16
Mi-Hee Lim, In Cheul Jeung, Jinyoung Jeong, Sung-Jin Yoon, Sang-Hyun Lee, Jongjin Park, Yu-Seon Kang, Hansu Lee, Young-Jun Park, Hee Gu Lee, Seon-Jin Lee, Baek Soo Han, Nam Woong Song, Sang Chul Lee, Jang-Seong Kim, Kwang-Hee Bae, Jeong-Ki Min
Despite the rapid expansion of the biomedical applications of graphene oxide (GO), safety issues related to GO, particularly with regard to its effects on vascular endothelial cells (ECs), have been poorly evaluated. To explore possible GO-mediated vasculature cytotoxicity and determine lateral GO size relevance, we constructed four types of GO: micrometer-sized GO (MGO; 1089.9 ± 135.3 nm), submicrometer-sized GO (SGO; 390.2 ± 51.4 nm), nanometer-sized GO (NGO; 65.5 ± 16.3 nm), and graphene quantum dots (GQDs)...
September 15, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27597657/exceedingly-higher-co-loading-of-curcumin-and-paclitaxel-onto-polymer-functionalized-reduced-graphene-oxide-for-highly-potent-synergistic-anticancer-treatment
#17
Kasturi Muthoosamy, Ibrahim Babangida Abubakar, Renu Geetha Bai, Hwei-San Loh, Sivakumar Manickam
Metastasis of lung carcinoma to breast and vice versa accounts for one of the vast majority of cancer deaths. Synergistic treatments are proven to be the effective method to inhibit malignant cell proliferation. It is highly advantageous to use the minimum amount of a potent toxic drug, such as paclitaxel (Ptx) in ng/ml together with a natural and safe anticancer drug, curcumin (Cur) to reduce the systemic toxicity. However, both Cur and Ptx suffer from poor bioavailability. Herein, a drug delivery cargo was engineered by functionalizing reduced graphene oxide (G) with an amphiphilic polymer, PF-127 (P) by hydrophobic assembly...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27377242/polydopamine-functionalized-graphene-oxide-loaded-with-gold-nanostars-and-doxorubicin-for-combined-photothermal-and-chemotherapy-of-metastatic-breast-cancer
#18
Fengyang Wang, Qianqian Sun, Bing Feng, Zhiai Xu, Junying Zhang, Jie Xu, Linlin Lu, Haijun Yu, Mingwei Wang, Yaping Li, Wen Zhang
Breast cancer is the leading cancer type diagnosed in the female population, and cancer metastasis is the main reason for cancer-caused mortality. A novel nanoplatform is herein presented integrating polydopamine-functionalized nanosized reduced graphene oxide (NRGO), gold nanostars (GNS), and doxorubicin (DOX) (denoted as NRGO-GNS@DOX) for combinational treatment of metastatic breast cancer. Upon localized near infrared (NIR) laser irradiation, the NRGO-GNS@DOX nanocomposites induce significant cytotoxicity in 4T1 breast cancer cells due to a cumulative therapy effect of NRGO-GNS-elicited hyperthermia and DOX-induced cytotoxicity...
September 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27324937/graphene-enhances-cellular-proliferation-through-activating-the-epidermal-growth-factor-receptor
#19
Wei Liu, Cheng Sun, Chunyang Liao, Lin Cui, Haishan Li, Guangbo Qu, Wenlian Yu, Naining Song, Yuan Cui, Zheng Wang, Wenping Xie, Huiming Chen, Qunfang Zhou
Graphene has promising applications in food packaging, water purification, and detective sensors for contamination monitoring. However, the biological effects of graphene are not fully understood. It is necessary to clarify the potential risks of graphene exposure to humans through diverse routes, such as foods. In the present study, graphene, as the model nanomaterial, was used to test its potential effects on the cell proliferation based on multiple representative cell lines, including HepG2, A549, MCF-7, and HeLa cells...
July 27, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27255045/-the-effects-of-graphene-quantum-dots-on-hematopoietic-system-in-rats
#20
Ting-jian Wang, Sha-li Wang
OBJECTIVE: To study the effects of graphene quantum dots (GQDs) on hematopoietic system in rats. METHODS: Thirty male SD rats were randomly divided into three groups (n = 10): control group, high dose group (10 mg/kg · d), low dose group (5 mg/kg · d), The rats in experimental group were intravenous injected with GQDs for 28 days and those in control group were injected with normal saline at the same volume. Routine blood and the function of liver and kidney were detected by instrument analysis...
January 2016: Chinese Journal of Applied Physiology
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