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Li-Wei Chiu, Matthew J Heckert, You You, Nicholas Albanese, Tamara Fenwick, Daniel L Siehl, Linda A Castle, Yumin Tao
Auxin homeostasis is a highly-regulated process that must be maintained to allow auxin to exert critical growth and developmental controls. Auxin conjugase and hydrolase family proteins play important roles in auxin homeostasis through means of storage, activation, inactivation, response inhibition, and degradation of auxins in plants. We systematically evaluated 60 GH3 proteins from diverse plant species for amino acid conjugation activity with the known substrates jasmonic acid (JA), indole-3-acetic acid (IAA), and 4-hydroxybenzoate (4-HBA)...
August 8, 2018: Plant & Cell Physiology
Gad Murenzi, Jean-Claude Dusingize, Theogene Rurangwa, Jean d'Amour Sinayobye, Athanase Munyaneza, Anthere Murangwa, Thierry Zawadi, Tiffany Hebert, Pacifique Mugenzi, Adebola Adedimeji, Leon Mutesa, Kathryn Anastos, Philip E Castle
INTRODUCTION: The optimal method(s) for screening HIV-infected women, especially for those living in sub-Saharan Africa, for cervical precancer and early cancer has yet to be established. METHODS AND ANALYSIS: A convenience sample of >5000 Rwandan women, ages 30-54 years and living with HIV infection, is being consented and enroled into a cross-sectional study of cervical cancer screening strategies. Participants are completing an administered short risk factor questionnaire and being screened for high-risk human papillomavirus (hrHPV) using the Xpert HPV assay (Cepheid, Sunnyvale, California, USA), unaided visual inspection after acetic acid (VIA) and aided VIA using the Enhanced Visual Assessment (EVA) system (Mobile ODT, Tel Aviv, Israel)...
August 5, 2018: BMJ Open
Bracha Shraibman, Eilon Barnea, Dganit Melamed Kadosh, Yael Haimovich, Gleb Slobodin, Itzhak Rosner, Carlos López-Larrea, Norbert Hilf, Sabrina Kuttruff, Colette Song, Cedrik Britten, John Castle, Sebastian Kreiter, Katrin Frenzel, Marcos Tatagiba, Ghazaleh Tabatabai, Pierre-Yves Dietrich, Valérie Dutoit, Wolfgang Wick, Michael Platten, Frank Winkler, Andreas Von Deimling, Judith Kroep, Juan Sahuquillo, Francisco Martinez-Ricarte, Jordi Rodon, Ulrik Lassen, Christian Ottensmeier, Sjoerd H van der Burg, Per Thor Straten, Hans Skovgaard Poulsen, Berta Ponsati, Hideho Okada, Hans Georg Rammensee, Ugur Sahin, Harpreet Singh, Arie Admon
Glioblastoma multiforme (GBM) is the most aggressive brain tumor with poor prognosis to most patients. Immunotherapy of GBM is a potentially beneficial treatment option, whose optimal implementation may depend on familiarity with tumor specific antigens, presented as HLA peptides by the GBM cells. Furthermore, early detection of GBM, such as by a routine blood test, may improve survival, even with the current treatment modalities. This study includes large-scale analyses of the HLA peptidome (immunopeptidome) of the plasma-soluble HLA molecules (sHLA) of 142 plasma samples, and the membranal HLA of GBM tumors of 10 of these patients' tumor samples...
August 2, 2018: Molecular & Cellular Proteomics: MCP
Glenn D Castle, Graham A Mills, Adil Bakir, Anthony Gravell, Melanie Schumacher, Kate Snow, Gary R Fones
Metaldehyde is a molluscicide and the active ingredient in formulated slug pellets used for the protection of crops. Due to its mobility in the environment it is frequently found in river catchments, often at concentrations exceeding the EU Drinking Water Directive limit of 100 ng L-1 for a single pesticide. This presents a major problem for water companies in the UK where such waters are abstracted for production of potable drinking water supplies. Therefore, it is important to understand the sources, transport and fate of this emerging pollutant of concern in the aquatic environment...
July 31, 2018: Environmental Science. Processes & Impacts
Lucia Kraková, Katarína Šoltys, Andrea Puškárová, Mária Bučková, Lenka Jeszeová, Marcel Kucharík, Jaroslav Budiš, Ľubomír Orovčík, Tomáš Szemes, Domenico Pangallo
This microbiological survey was performed to determine the conservation state of a mummy in the Slovak castle of Krásna Hôrka and its surrounding environment. Culture-dependent identification was coupled with biodegradation assays on keratin, gelatin and cellulose. Next Generation Sequencing using Illumina platform was employed for a deeper microbial investigation. Three environmental samples were collected: from the glass of the sarcophagus, from the air inside it, and from the air of the chapel where the mummy is located...
July 26, 2018: Environmental Microbiology
Hui Cong, Xinghua Zhao, Brian T Castle, Emily J Pomeroy, Bo Zhou, John Lee, Yi Wang, Tengfei Bian, Zhenyuan Miao, Wannian Zhang, Yuk Yin Sham, David J Odde, Craig E Eckfeldt, Chengguo Xing, Chunlin Zhuang
Multidrug resistance and toxic side effects are the major challenges in cancer treatment with microtubule-targeting agents (MTAs), and thus, there is an urgent clinical need for new therapies. Chalcone, a common simple scaffold found in many natural products, is widely used as a privileged structure in medicinal chemistry. We have previously validated tubulin as the anticancer target for chalcone derivatives. In this study, an α-methyl-substituted indole-chalcone (FC77) was synthesized and found to exhibit an excellent cytotoxicity against the NCI-60 cell lines (average concentration causing 50% growth inhibition = 6 nM)...
August 9, 2018: Molecular Pharmaceutics
Kirsty Forsdike, Manjula O'Connor, David Castle, Kelsey Hegarty
OBJECTIVE: Examine knowledge, opinions and practices of psychiatrists and trainees in responding to domestic violence (DV). METHOD: Online survey including two sub-scales from PREMIS (Physician Readiness to Manage Intimate Partner Violence Survey): knowledge (10 items) and preparedness (10 items). RESULTS: Of psychiatrists completing the survey (216), 47% had received less than 2 hours of training in DV. PREMIS findings showed moderate knowledge of, and preparedness to deal with, DV...
July 26, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
Shadi Ferdosi, Thai H Ho, Erik P Castle, Melissa L Stanton, Chad R Borges
Despite systemic therapy and cystectomy, bladder cancer is characterized by a high recurrence rate. Serum glycomics represents a promising source of prognostic markers for monitoring patients. Our approach, which we refer to as "glycan node analysis", constitutes the first example of molecularly "bottom-up" glycomics. It is based on a global glycan methylation analysis procedure that is applied to whole blood plasma/serum. The approach detects and quantifies partially methylated alditol acetates arising from unique glycan features such as α2-6 sialylation, β1-4 branching, and core fucosylation that have been pooled together from across all intact glycans within a sample into a single GC-MS chromatographic peak...
2018: PloS One
Massimiliano Orri, Lea C Perret, Gustavo Turecki, Marie-Claude Geoffroy
BACKGROUND: Irritability is gaining considerable attention as a risk factor for suicide-related outcomes (suicide mortality, attempt, and ideation). However, the evidence of this association is scant. We conducted a systematic review of the evidence regarding the associations between irritability and suicide-related outcomes across the life-course. METHODS: We conducted a systematic search on Medline and PsycINFO (up to January 2018) for original articles published in English investigating the association between irritability and suicide-related outcomes...
July 4, 2018: Journal of Affective Disorders
(no author information available yet)
Original article: Castles, A., Rastle, K., & Nation, K. (2018). Ending the reading wars: Reading acquisition from novice to expert. Psychological Science in the Public Interest, 19, 5-51. doi: 10.1177/1529100618772271 On page 23, in the left column, at the beginning of the first full paragraph, four sentences were inadvertently omitted during the editing process. Those sentences are as follows: This characterization changes substantially in cases of words with more than one morpheme. Morphemes are the minimum meaning-bearing units in English (e...
July 1, 2018: Psychological Science in the Public Interest: a Journal of the American Psychological Society
Kassem Faraj, Kelli Gross, Christopher Beauchamp, Erik Castle, Aqsa Khan
No abstract text is available yet for this article.
September 2018: Urology Case Reports
Malcolm Battersby, Michael R Kidd, Julio Licinio, Philip Aylward, Amanda Baker, Julie Ratcliffe, Stephen Quinn, David J Castle, Sara Zabeen, A Kate Fairweather-Schmidt, Sharon Lawn
BACKGROUND: The estimated 300,000 adults in Australia with severe mental illness (SMI) have markedly reduced life expectancy compared to the general population, mainly due to physical health comorbidities. Cardiovascular disease (CVD) is the commonest cause of early death and people with SMI have high rates of most modifiable risk factors, with associated quality of life (QoL) reduction. High blood pressure, smoking, dyslipidaemia, diabetes and obesity are major modifiable CVD risk factors...
July 11, 2018: Trials
Malik Elharram, Natalie Dayan, Amanpreet Kaur, Tara Landry, Louise Pilote
OBJECTIVE: To systematically review and summarize studies investigating an association between a history of preeclampsia and cognitive function later in life. DATA SOURCES: Studies published before August 2017 were identified without any language restriction or study design limits through electronic searches of 10 main databases including MEDLINE and METHODS OF STUDY SELECTION: We considered all observational studies that included preeclampsia as a clearly defined prespecified risk factor and that examined a cognition-related outcome measure including validated cognitive tests, magnetic resonance brain imaging, or a clinical diagnosis of dementia...
August 2018: Obstetrics and Gynecology
Ana Lusicic, Koen Rj Schruers, Stefano Pallanti, David J Castle
Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neurostimulation technique receiving increasing attention in the treatment of different psychiatric disorders. Evidence for rTMS use in obsessive-compulsive disorder (OCD) is accumulating and informing further developments in the neurostimulation field, the latest being deep transcranial magnetic stimulation (dTMS). dTMS allows direct stimulation of deeper subcortical structures and larger brain volume than conventional rTMS. Underlying neurobiological mechanisms related to transcranial magnetic stimulation are still under evaluation, but appear to offer a novel "third" way of addressing symptoms via localized electrical stimulation compared to pharmacotherapy and psychotherapy approaches...
2018: Neuropsychiatric Disease and Treatment
Sharon A Andreason, Nilima Prabhaker, Steven J Castle, Fatemeh Ganjisaffar, David R Haviland, Beth Stone-Smith, Thomas M Perring
Pest management for the glassy-winged sharpshooter, Homalodisca vitripennis Germar (Hemiptera: Cicadellidae), in Kern County, California relies on the application of insecticides. These treatments have contributed to low H. vitripennis field counts since applications were initiated in 2001. However, densities have been high in recent years despite continued management, prompting efforts to evaluate the susceptibility of current populations to insecticides. H. vitripennis adults were subjected to bioassays with five commonly applied insecticides, and the results were compared to baseline toxicities determined in 2002...
July 3, 2018: Journal of Economic Entomology
Naitielle Pantano, Brady Hunt, Richard A Schwarz, Sonia Parra, Katelin Cherry, Júlio César Possati-Resende, Adhemar Longatto-Filho, José Humberto Tavares Guerreiro Fregnani, Philip E Castle, Kathleen Schmeler, Rebecca Richards-Kortum
Proflavine is an acridine dye used with high-resolution microendoscopy for in vivo diagnostic evaluation of cervical epithelial cells. However, there are concerns that even short-term exposure of cervical tissue to dilute proflavine may increase cervical cancer risk. We performed a retrospective analysis of women referred for colposcopy to Barretos Cancer Hospital comparing the risk of cervical disease progression in those whose cervical tissue was (n = 232) or was not exposed (n = 160) to proflavine. Patients in both groups underwent treatment and follow-up based on histopathologic results and per the local standards of care...
July 7, 2018: Photochemistry and Photobiology
Dipen J Parekh, Isildinha M Reis, Erik P Castle, Mark L Gonzalgo, Michael E Woods, Robert S Svatek, Alon Z Weizer, Badrinath R Konety, Mathew Tollefson, Tracey L Krupski, Norm D Smith, Ahmad Shabsigh, Daniel A Barocas, Marcus L Quek, Atreya Dash, Adam S Kibel, Lynn Shemanski, Raj S Pruthi, Jeffrey Scott Montgomery, Christopher J Weight, David S Sharp, Sam S Chang, Michael S Cookson, Gopal N Gupta, Alex Gorbonos, Edward M Uchio, Eila Skinner, Vivek Venkatramani, Nachiketh Soodana-Prakash, Kerri Kendrick, Joseph A Smith, Ian M Thompson
BACKGROUND: Radical cystectomy is the surgical standard for invasive bladder cancer. Robot-assisted cystectomy has been proposed to provide similar oncological outcomes with lower morbidity. We aimed to compare progression-free survival in patients with bladder cancer treated with open cystectomy and robot-assisted cystectomy. METHODS: The RAZOR study is a randomised, open-label, non-inferiority, phase 3 trial done in 15 medical centres in the USA. Eligible participants (aged ≥18 years) had biopsy-proven clinical stage T1-T4, N0-N1, M0 bladder cancer or refractory carcinoma in situ...
June 23, 2018: Lancet
Anca Dorhoi, Jonathan Jantsch, Norbert Reiling
No abstract text is available yet for this article.
July 2018: European Journal of Immunology
Mendel Castle-Kirszbaum, Tony Goldschlager, Benjamin Ho, Yi Yuen Wang, James King
PURPOSE: The pituitary gland is an unusual site for metastatic spread, but as patients with metastatic malignancy are living longer, it may become more prevalent. Compression of important anatomy adjacent to the sella may produce disabling symptoms and endocrine derangement, leading to significant morbidity. METHODS: An ambispective review of patient records between 2013 and 2017 from three neurosurgical centres was performed. After identifying cases, further investigation was performed to evaluate patient demographic, symptoms at presentation, radiological and histological findings, management, and outcome...
July 5, 2018: Pituitary
Anders Schouw, Francesca Vulcano, Irene Roalkvam, William Peter Hocking, Eoghan Reeves, Runar Stokke, Gunhild Bødtker, Ida Helene Steen
Abyssivirga alkaniphila strain L81T , recently isolated from a black smoker biofilm at the Loki’s Castle hydrothermal vent field, was previously described as a mesophilic, obligately anaerobic heterotroph able to ferment carbohydrates, peptides, and aliphatic hydrocarbons. The strain was classified as a new genus within the family Lachnospiraceae . Herein, its genome is analyzed and A. alkaniphila is reassigned to the genus Vallitalea as a new strain of V. guaymasensis , designated V. guaymasensis strain L81...
July 4, 2018: Microorganisms
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