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Ravi Kondama Reddy, Rubin Pooni, Dessi P Zaharieva, Brian Senf, Joseph El Youssef, Eyal Dassau, Francis J Doyle Iii, Mark A Clements, Michael R Rickels, Susana R Patton, Jessica R Castle, Michael C Riddell, Peter G Jacobs
BACKGROUND: Wrist-worn activity monitors are often used to monitor heart rate (HR) and energy expenditure (EE) in a variety of settings including more recently in medical applications. The use of real-time physiological signals to inform medical systems including drug delivery systems and decision support systems will depend on the accuracy of the signals being measured, including accuracy of HR and EE. Prior studies assessed accuracy of wearables only during steady-state aerobic exercise...
December 10, 2018: JMIR MHealth and UHealth
Vassilis Genoud, Eliana Marinari, Sergey I Nikolaev, John C Castle, Valesca Bukur, Pierre-Yves Dietrich, Hideho Okada, Paul R Walker
Immune checkpoint blockade (ICB) is currently evaluated in patients with glioblastoma (GBM), based on encouraging clinical data in other cancers, and results from studies with the methylcholanthrene-induced GL261 mouse glioma. In this paper, we describe a novel model faithfully recapitulating some key human GBM characteristics, including low mutational load, a factor reported as a prognostic indicator of ICB response. Consistent with this observation, SB28 is completely resistant to ICB, contrasting with treatment sensitivity of the more highly mutated GL261...
2018: Oncoimmunology
Rebecca McKetin, Alexandra Voce, Richard Burns, Robert Ali, Dan I Lubman, Amanda L Baker, David J Castle
The inability to distinguish clearly between methamphetamine-related psychosis and schizophrenia has led to the suggestion that "methamphetamine psychosis" does not represent a distinct diagnostic entity but rather that the drug has triggered a vulnerability to schizophrenia. We tested this possibility by exploring the latent class structure of psychotic symptoms amongst people who use the drug and examining how these latent symptom profiles correspond to a diagnosis of schizophrenia. Latent class analysis was carried out on the lifetime psychotic symptoms of 554 current methamphetamine users, of whom 40 met the DSM-IV criteria for schizophrenia...
2018: Frontiers in Psychiatry
Dan Remley, Lisa Franzen-Castle, Lacey McCormack, Heather A Eicher-Miller
Objectives: Food insecurity and diet-related chronic health conditions are interrelated problems in rural communities. The population facing such outcomes may rely on food pantries as a way to gain access to food. Many food pantries use a traditional distribution model that restricts choice. Yet, dietary recommendations and the need to economize food resources place many challenges on households. In this research, we sought to determine whether clients self-reporting chronic health conditions in their households have unique perceptions about food pantries and their ability to meet needs...
January 1, 2019: American Journal of Health Behavior
Alexia Bourgeois, Emmanuel Badier, Naem Baron, Fabien Carruzzo, Patrik Vuilleumier
Rewards constitute crucial signals that motivate approach behavior and facilitate the perceptual processing of objects associated with favorable outcomes in past encounters. Reward-related influences on perception and attention have been reliably observed in studies where a reward is paired with a unidimensional low-level visual feature, such as the color or orientation of a line in visual search tasks. However, our environment is drastically different and composed of multidimensional and changing visual features, encountered in complex and dynamic scenes...
2018: PloS One
Melissa D Olfert, Rebecca L Hagedorn, Makenzie L Barr, Sarah E Colby, Kendra K Kattelmann, Lisa Franzen-Castle, Adrienne A White
OBJECTIVE: To evaluate barriers to dissemination and implementation and perceptions of the Evidence-Based Forecast Capture, Assemble, Sustain, Timelessness (eB4CAST) dissemination infographic tool as part of iCook 4-H dissemination. DESIGN: Online surveys and phone interviews. PARTICIPANTS: Experts (n = 35) in community research completed the survey; 13 completed the interview. MAIN OUTCOMES MEASURE: Experts' perceptions of eB4CAST reports used for iCook 4-H dissemination...
December 1, 2018: Journal of Nutrition Education and Behavior
Kendra K Kattelmann, Jessica R Meendering, Emily J Hofer, Chase M Merfeld, Melissa D Olfert, Rebecca L Hagedorn, Sarah E Colby, Lisa Franzen-Castle, Jon Moyer, Douglas R Mathews, Adrienne A White
OBJECTIVE: To report physical activity and sedentary time outcomes of youth in iCook 4-H. STUDY DESIGN AND SETTING: iCook 4-H was a 5-state, randomized, control-treatment, family-based childhood obesity prevention intervention promoting cooking, eating, and playing together. PARTICIPANTS AND INTERVENTION: Youth aged 9-10 years and the main preparer of their meals participated in the 12-week program followed by monthly newsletters and biyearly booster sessions until 24 months...
December 1, 2018: Journal of Nutrition Education and Behavior
Sharlene A Greenwood, Ellen Castle, Herolin Lindup, Juliet Mayes, Iain Waite, Denise Grant, Emmanuel Mangahis, Olivia Crabb, Kamer Shevket, Iain C Macdougall, Helen L MacLaughlin
Background: Twelve weeks of renal rehabilitation (RR) have been shown to improve exercise capacity in patients with chronic kidney disease (CKD); however, survival following RR has not been examined. Methods: This study included a retrospective longitudinal analysis of clinical service outcomes. Programme completion and improvement in exercise capacity, characterised as change in incremental shuttle walk test (ISWT), were analysed with Kaplan-Meier survival analyses to predict risk of a combined event including death, cerebrovascular accident, myocardial infarction and hospitalisation for heart failure in a cohort of patients with CKD...
November 30, 2018: Nephrology, Dialysis, Transplantation
Tanya M Horacek, Elif Dede Yildirim, Erin Kelly, Adrienne A White, Karla P Shelnutt, Kristin Riggsbee, Melissa D Olfert, Jesse Stabile Morrell, Anne E Mathews, Terezie T Mosby, Tandalayo Kidd, Kendra Kattelmann, Geoffrey Greene, Lisa Franzen-Castle, Sarah Colby, Carol Byrd-Bredbenner, Onikia Brown
Background This paper describes the development, reliability, and convergent validity of a practical tool-the Convenience Store Supportive Healthy Environment for Life-Promoting Food (SHELF) Audit. Methods Audit items included: a variety of fresh, processed, and frozen fruits and vegetables; low-fat dairy products; healthy staples and frozen meals; healthy food incentive programs; items sold in check-out areas; portion/cup sizes; and pricing. Each audit item was scored using a five-point semantic-differential scale (1 = provides little or no support for healthful foods to 5 = provides high support for healthful foods)...
November 28, 2018: International Journal of Environmental Research and Public Health
David J Castle, Robert D Goldney
No abstract text is available yet for this article.
December 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
Melissa D Olfert, Sina J King, Rebecca L Hagedorn, Makenzie L Barr, Barbara A Baker, Sarah E Colby, Kendra K Kattelmann, Lisa Franzen-Castle, Adrienne A White
OBJECTIVE: To describe the impact of the iCook 4-H intervention study based on data gathered through ripple effect mapping focus groups through an explorative approach. DESIGN: Youth-adult dyads responded about ways in which iCook had affected the individual, family, and community. Three questions were asked: (1) What were people doing differently as a result of iCook? (2) Who benefited from iCook and how? (3) Were there changes in the way community groups and institutions did things as a result of iCook? SETTING: Ripple effect mapping sessions took place across 5 states (Maine, Nebraska, South Dakota, Tennessee, and West Virginia)...
October 25, 2018: Journal of Nutrition Education and Behavior
Suzanne H Verver, Mathijs P J Vervloed, Bert Steenbergen
BACKGROUND: Children with visual impairments (VIs) face challenges in social play activities, which limits their opportunities to practice social skills. AIMS: We investigated whether augmented toys were effective to facilitate play in 52 children with VIs who attended special schools for students with visual impairments and blindness. METHODS AND PROCEDURES: 52 children with VIs (mean age: 9.22 years, SD = 2.07) played three times with both an augmented and a non-augmented toy...
November 24, 2018: Research in Developmental Disabilities
Genevieve McArthur, Yumi Sheehan, Nicholas A Badcock, Deanna A Francis, Hua-Chen Wang, Saskia Kohnen, Erin Banales, Thushara Anandakumar, Eva Marinus, Anne Castles
BACKGROUND: The reading skills of 16% of children fall below the mean range for their age, and 5% of children have significant and severe reading problems. Phonics training is one of the most common reading treatments used with poor readers, particularly children. OBJECTIVES: To measure the effect of phonics training and explore the impact of various factors, such as training duration and training group size, that might moderate the effect of phonics training on literacy-related skills in English-speaking poor readers...
November 14, 2018: Cochrane Database of Systematic Reviews
Ian Howard, Bernard Pillay, Nicholas Castle, Loua Al Shaikh, Robert Owen, David Williams
BACKGROUND: Emergency Care has previously been identified as an area of significant concern regarding the prevalence of Adverse Events (AEs). However, the majority of this focus has been on the in-hospital setting, with little understanding of the identification and incidence of AEs in the prehospital environment. METHOD: The early development and testing of Emergency Medical Services (EMS) specific triggers for the identification of AEs and Harm has been previously described...
November 26, 2018: BMC Emergency Medicine
Douglas Mathews, Zachary J Kunicki, Sarah Colby, Lisa Franzen-Castle, Kendra Kattelmann, Melissa D Olfert, Adrienne A White
OBJECTIVE: To develop and test the validity of program outcome evaluation instruments for cooking, eating, and playing together for obesity prevention during iCook 4-H. DESIGN: Instrument development for both youth and adults through pre-post testing of items newly constructed and compiled to address key curriculum constructs. Testing occurred throughout program intervention and dissemination to determine dimensionality, internal consistency and test-retest reliability, and validity...
November 21, 2018: Journal of Nutrition Education and Behavior
Ji Young Choi, Sherri Castle, Margaret Burchinal, Diane Horm, Shannon Guss, Gary E Bingham
Using data from a large study of 78 high-quality Head Start classrooms in 12 sites across the U.S., this study examined whether peers' receptive vocabulary skills and teacher-reported social-emotional (S-E) functioning (i.e., behavior problems and self-regulation) measured at the beginning of the preschool year were related to children's gains in these three domains over a school year. Analyses included over 75% of the children in each classroom and produced three noteworthy findings. First, children in classrooms where average peers had higher behavior problems demonstrated increased teacher-reported behavior problems themselves at the end of the year...
December 2018: Journal of School Psychology
Julia Brodski, Susan L Rossell, David J Castle, Eric J Tan
OBJECTIVES: Recognition of cognitive impairment in chronic kidney disease (CKD) and its impact on functioning in adults is growing. The vast majority of studies to date have been conducted in older populations where CKD is more pronounced; however, the degree to which age-related cognitive changes could be influencing these findings remains unaddressed. This current study thus aimed to review cognitive impairment findings by stage in non-elderly CKD samples. METHODS: PubMed and Medline via Scopus were searched for cross-sectional or cohort studies and randomized controlled trials that assessed cognitive function in individuals with CKD in any research setting...
November 22, 2018: Journal of the International Neuropsychological Society: JINS
D Camp, A Haage, V Solianova, W M Castle, Q A Xu, E Lostchuck, B T Goult, G Tanentzapf
Attachment of cells to the Extracellular Matrix (ECM) via integrins is essential for animal development and tissue maintenance. The cytoplasmic protein Talin is necessary for linking integrins to the cytoskeleton and its recruitment is a key step in the assembly of the adhesion complex. However, the mechanisms that regulate Talin recruitment to sites of adhesion in vivo are still not well understood. Here we show that Talin recruitment to, and maintenance at, sites of integrin-mediated adhesion requires a direct interaction between Talin and the GTPase Rap1...
November 16, 2018: Journal of Cell Science
Michael J Castle, Yuhsiang Cheng, Aravind Asokan, Mark H Tuszynski
Several neurological disorders may benefit from gene therapy. However, even when using the lead vector candidate for intrathecal administration, adeno-associated virus serotype 9 (AAV9), the strength and distribution of gene transfer to the brain are inconsistent. On the basis of preliminary observations that standard intrathecal AAV9 infusions predominantly drive reporter gene expression in brain regions where gravity might cause cerebrospinal fluid to settle, we tested the hypothesis that counteracting vector "settling" through animal positioning would enhance vector delivery to the brain...
November 2018: Science Advances
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