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Nicolas Clementy, Yann Ancedy, Arnaud Bisson, Clémentine Andre, Bertrand Pierre, Laurent Fauchier, Dominique Babuty
INTRODUCTION: Ablation of premature ventricular contractions has emerged as a safe and effective treatment in patients experiencing a high premature ventricular contractions burden. Mapping of premature ventricular contractions origin may sometimes be challenging. We sought to evaluate the accuracy of a new electrophysiological criterion, the Distal-to-Proximal Delay, at localizing the optimal site for ablation of ventricular ectopic foci. METHODS AND RESULTS: Consecutive patients with ablation attempts of symptomatic premature ventricular contractions were included...
December 5, 2018: Journal of Cardiovascular Electrophysiology
Célia Fourrier, Clémentine Bosch-Bouju, Raphaël Boursereau, Julie Sauvant, Agnès Aubert, Lucile Capuron, Guillaume Ferreira, Sophie Layé, Nathalie Castanon
Although the high prevalence of anxiety in obesity increasingly emerges as significant risk factor for related severe health complications, the underlying pathophysiological mechanisms remain poorly understood. Considering that chronic inflammation is a key component of obesity and is well known to impact brain function and emotional behavior, we hypothesized that it may similarly contribute to the development of obesity-related anxiety. This hypothesis was experimentally tested by measuring whether chronic food restriction, a procedure known to reduce inflammation, or chronic anti-inflammatory treatment with ibuprofen improved anxiety-like behavior and concomitantly decreased peripheral and/or hippocampal inflammation characterizing a model of severe obesity, the db/db mice...
November 30, 2018: Brain, Behavior, and Immunity
Guy Rostoker, Christelle Loridon, Mireille Griuncelli, Clémentine Rabaté, Fanny Lepeytre, Pablo Ureña-Torres, Belkacem Issad, Nasredine Ghali, Yves Cohen
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a spectrum of diseases including steatosis, nonalcoholic steatohepatitis (NASH), cirrhosis, and end-stage liver failure. Hepatic iron accumulation has been linked to hepatic fibrosis severity in NASH and NAFLD. Iron overload induced by parenteral (IV) iron therapy is a potential clinical problem in dialysis patients. We analyzed the hypothetical triggering and aggravating role of iron on NAFLD in patients on dialysis. METHODS: Liver iron concentration (LIC) and hepatic proton density fat fraction (PDFF) were analyzed prospectively in 68 dialysis patients by magnetic resonance imaging (MRI)...
November 27, 2018: EBioMedicine
Clémentine Minozzi, Jean-Christophe Grenier-Petel, Shawn Parisien-Collette, Shawn K Collins
A copper-based photocatalyst, Cu(tmp)(BINAP)BF4 , was found to be active in a photoredox Appel-type conversion of alcohols to bromides. The catalyst was identified from a screening of 50 complexes and promoted the transformation of primary and secondary alcohols to their corresponding bromides and carboxylic acids to their anhydrides. The protocol was also amendable and optimized under continuous flow conditions.
2018: Beilstein Journal of Organic Chemistry
Clémentine Dressaire, Vânia Pobre, Sandrine Laguerre, Laurence Girbal, Cecilia Maria Arraiano, Muriel Cocaign-Bousquet
BACKGROUND: Exoribonucleases are crucial for RNA degradation in Escherichia coli but the roles of RNase R and PNPase and their potential overlap in stationary phase are not well characterized. Here, we used a genome-wide approach to determine how RNase R and PNPase affect the mRNA half-lives in the stationary phase. The genome-wide mRNA half-lives were determined by a dynamic analysis of transcriptomes after transcription arrest. We have combined the analysis of mRNA half-lives with the steady-state concentrations (transcriptome) to provide an integrated overview of the in vivo activity of these exoribonucleases at the genome-scale...
November 29, 2018: BMC Genomics
Clémentine Sarkozy, Matthew J Maurer, Brian K Link, Hervé Ghesquieres, Emmanuelle Nicolas, Carrie A Thompson, Alexandra Traverse-Glehen, Andrew L Feldman, Cristine Allmer, Susan L Slager, Stephen M Ansell, Thomas M Habermann, Emmanuel Bachy, James R Cerhan, Gilles Salles
PURPOSE: Although the life expectancy of patients with follicular lymphoma (FL) has increased, little is known of their causes of death (CODs) in the rituximab era. PATIENTS AND METHODS: We pooled two cohorts of newly diagnosed patients with FL grade 1-3A. Patients were enrolled between 2001 and 2013 in two French referral institutions (N = 734; median follow-up 89 months) and 2002 and 2012 in the University of Iowa and Mayo Clinic Specialized Program of Research Excellence (SPORE; N = 920; median follow-up 84 months)...
November 27, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Sarah L Dalglish, Jessica Vandermark, Clémentine Rossier, Adama Kemou, Hope Neighbor
Global initiatives aim to add 120 million new family planning (FP) users by 2020; however supply-side interventions may be reaching the limits of their effectiveness in some settings. Our case study in Niger used demand analysis techniques from marketing science. We performed a representative survey (N = 2,004) on women's FP knowledge, attitudes, needs, and behaviors, then used latent class analysis to produce a segmentation of women based on their responses. We found that Nigerien women's demand for modern FP methods was low, with majorities aware of modern methods but much smaller proportions considering use, trying modern methods, or using one consistently...
November 26, 2018: Studies in Family Planning
Clémentine Sciard, Sophie Collardeau-Frachon, Anthony Atallah, Danièle Combourieu, Jérôme Massardier, Sophie Heissat, Pascal Gaucherand, Laurent Guibaud, Mona Massoud
We report prenatal imaging features of four cases of neonatal hemochromatosis due to an alloimmune disease. All cases exhibited intra uterine growth restriction (IUGR) without arguments for a vascular etiology, associated with oligohydramnios. Placental hydrops was present in 75% of cases. Splenomegaly was identified in one case. Other causes of NH have been ruled out during diagnostic workup including karyotype, detection of IGFBP-1 to evaluate a premature rupture of membranes, maternal serologic tests. MRI was performed in two cases and showed an atrophic liver associated with a low signal intensity on T2-sequence in one case...
November 19, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Patrick Murigu Kamau Njage, Clementine Henri, Pimlapas Leekitcharoenphon, Michel-Yves Mistou, Rene S Hendriksen, Tine Hald
Next-generation sequencing (NGS) data present an untapped potential to improve microbial risk assessment (MRA) through increased specificity and redefinition of the hazard. Most of the MRA models do not account for differences in survivability and virulence among strains. The potential of machine learning algorithms for predicting the risk/health burden at the population level while inputting large and complex NGS data was explored with Listeria monocytogenes as a case study. Listeria data consisted of a percentage similarity matrix from genome assemblies of 38 and 207 strains of clinical and food origin, respectively...
November 21, 2018: Risk Analysis: An Official Publication of the Society for Risk Analysis
Clémentine Broche, Pauline Pralong, Hugo Gil, Nassima Yahiaoui, Mireille Mousseau, Catharina Chatain, Jean-Pierre Jacquier, Julie Charles, Marie-Thérèse Leccia
No abstract text is available yet for this article.
November 21, 2018: Contact Dermatitis
Clémentine Mazoyer, Patrick Treacy, Laurent Turchi, Paul Antoine Lehur, Emmanuel Benizri, Antonio Iannelli
BACKGROUND: Obesity is a well-known risk factor for female pelvic floor disorders (PFD). This study assessed the effects of bariatric surgery (BS) on pelvic organ prolapse symptoms (POPs) and urinary (UI) and anal incontinence (AI) in morbidly obese women undergoing either sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB). METHODS: Morbidly obese women undergoing BS from June 2016 to May 2017 were prospectively included. POPs, UI, and AI were compared at baseline and at 1 year after surgery using validated questionnaires...
November 17, 2018: Obesity Surgery
Benjamin Herran, Nicolas Cerveau, Camille Houdelet, Clémentine Bernier, Catherine Debenest, Carine Delaunay, Maryline Raimond, Joanne Bertaux, Pierre Grève
The first protein which has been described to interact with the malacostracan Androgenic Gland Hormone (AGH) is a binding protein called IGFBP-rP1. It has been identified and studied in several species of decapods, in which its interaction with the masculinizing hormone and its expression patterns have been established in several ways. However, this protein remains uncharacterised to date in the other malacostracan orders, like Amphipoda and Isopoda, although they were historically the first ones in which the androgenic gland and the corresponding hormone were respectively described...
November 15, 2018: General and Comparative Endocrinology
Sandra De Barros, Flora Vayr, Fabien Despas, Mathilde Strumia, Clémentine Podevin, Martin Gauthier, Eric Delabesse, Jean-Marc Soulat, Guy Laurent, Françoise Huguet, Fabrice Herin
Patients with chronic myeloid leukemia treated with breakpoint cluster region-Abelson tyrosine kinase inhibitors are likely to survive in excess of 20 years after diagnosis. New challenges appear as we consider life after the disease, including professional challenges and the social reintegration of patients. The purpose of this study was to determine the impact of chronic myeloid leukemia on employment within 2 years after diagnosis. This prospective, observational study included patients diagnosed with chronic myeloid leukemia and treated with a tyrosine kinase inhibitor...
November 17, 2018: Annals of Hematology
Antonin Bal, Clémentine Sarkozy, Laurence Josset, Valérie Cheynet, Guy Oriol, Jérémie Becker, Gaëlle Vilchez, Pierre Sesques, François Mallet, Alexandre Pachot, Florence Morfin, Bruno Lina, Gilles Salles, Fréderic Reynier, Sophie Trouillet-Assant, Karen Brengel-Pesce
Over recent years, there has been increasing interest in the use of the anelloviruses, the major component of the human virome, for the prediction of post-transplant complications such as severe infections. Due to an important diversity, the comprehensive characterization of this viral family over time has been poorly studied. To overcome this challenge, we used a metagenomic next-generation sequencing (mNGS) approach with the aim of determining the individual anellovirus profile of autologous stem cell transplant (ASCT) patients...
November 14, 2018: Viruses
Miriam Franco, Clémentine Lantin, François-Xavier Dekeuleneer, Xavier Bongaerts, Juan Martin Tecco
BACKGROUND: Personality disorders are a class of mental diseases characterized by inflexible and maladaptive patterns of behavior, cognition, and inner experience, involving several areas of functioning, such as affectivity, impulse control, ways of perceiving and thinking and reaction to stress factors. In the literature, personality disorders have always been described as stable patterns of long duration, and their onset can be found during adolescence or early adulthood. These patterns are associated with significant distress or impairment in a patient's life in which a main element affects every aspect of living, and in which no biological or other pathologies exist to assist in its identification...
November 2018: Psychiatria Danubina
Clémentine Lantin, Miriam Franco, François-Xavier Dekeuleneer, Didier Chamart, Juan Martin Tecco
BACKGROUND: Neuroleptic malignant syndrome (NMS), which is linked to the use of antipsychotic medication, is a potentially lethal neurological emergency. The interest of our study is that NMS induced by the use of clotiapine has never previously been described. SUBJECTS AND METHODS: We present the case of a 61-year old man whose sleep disorders were treated with clotiapine 40 mg/day. After 7 days of taking 40 mg clotiapine, the patient presented with a deterioration of his general health which had gradually taken hold, with altered consciousness accompanied by generalised muscle rigidity and hypersalivation...
November 2018: Psychiatria Danubina
Thibaut Powolny, Renaud Scheifler, Francis Raoul, Clémentine Fritsch
In wildlife ecotoxicology, the rationale for using blood rather than other body fluids or tissues is that sampling blood is a minimally invasive technique without animal mortality, providing both ethical and scientific benefits. To date, few studies are available on the relationships between blood and organ metal concentrations of small mammals living in contaminated sites. The present work aimed to study the relationships between the concentrations of 18 essential and nonessential metals in blood and their concentrations in the liver and kidneys, two accumulation and target organs, in wood mice from a former lead and zinc smelter, Metaleurop Nord, in northern France...
November 4, 2018: Chemosphere
Clémentine Eloi, Gauthier Foulon, Laure Bridoux-Henno, Estelle Breton, Cecile Pelatan, Emilie Chaillou, Isabelle Grimal, Estelle Darviot, Emilie Carré, Swellen Gastineau, Yann Tourtelier, Dorothee Nicaise, Chloe Rousseau, Alain Dabadie
OBJECTIVES: Inflammatory Bowel Diseases (IBD) are chronic diseases which negatively affect the schooling of children. The aim is to analyze school absenteeism and its causes in children followed for IBD. METHODS: A prospective multicenter study of IBD patients aged from 5 to 18 years old, from September 2016 to June 2017. Data on absenteeism and its causes were collected via a monthly questionnaire completed by patients or their family by mail. The results were compared with existing data supplied by the school authorities (497 students without IBD divided by class)...
November 8, 2018: Journal of Pediatric Gastroenterology and Nutrition
Clementine Lasne, Belinda Van Heerwaarden, Carla M Sgrò, Tim Connallon
During local adaptation with gene flow, some regions of the genome are inherently more responsive to selection than others. Recent theory predicts that X-linked genes should disproportionately contribute to local adaptation relative to other genomic regions, yet this prediction remains to be tested. We carried out a multi-generation crossing scheme, using two cline-end populations of Drosophila melanogaster, to estimate the relative contributions of the X chromosome, autosomes and mitochondrial genome to adaptive divergence in four traits involved in local adaptation (wing size, and resistance to heat, desiccation, and starvation stresses)...
November 12, 2018: Evolution; International Journal of Organic Evolution
Clémentine Andre, Eric Piver, Romain Perault, Arnaud Bisson, Julien Pucheux, Emmanuelle Vermes, Bertrand Pierre, Laurent Fauchier, Dominique Babuty, Nicolas Clementy
BACKGROUND: Cardiac resynchronization therapy (CRT) reduces symptoms, morbidity and mortality in chronic heart failure patients with wide QRS complexes. However, approximately one third of CRT patients are non-responders. Myocardial fibrosis is known to be associated with absence of response. We sought to see whether galectin-3, a promising biomarker involved in fibrosis processes, could predict response and outcomes after CRT. METHODS: Consecutive patients eligible for implantation of a CRT device with a typical left bundle branch block ≥ 120 ms were prospectively included...
November 3, 2018: Journal of Translational Medicine
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