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Beatriz Navarro, Stefania Zicca, Maria Minutolo, Maria Saponari, Daniela Alioto, Francesco Di Serio
A new RNA virus has been identified from a sweet orange tree in southern Italy. This virus, tentatively named citrus virus A (CiVA), has a bipartite genome composed of (i) a negative-stranded (ns) RNA1, encoding the viral RNA-dependent RNA polymerase (RdRp), and (ii) an ambisense RNA2, coding for the putative movement protein (MP) and nucleocapsid protein (NP), with the two open reading frames separated by a long AU-rich intergenic region (IR) adopting a hairpin conformation. CiVA genomic RNAs and the encoded proteins resemble those of the recently discovered citrus concave gum-associated virus (CCGaV)...
2018: Frontiers in Microbiology
Clementine Bostantzoglou, Marianthi Iliopoulou, Torsten Gerriet Blum
No abstract text is available yet for this article.
September 2018: Journal of Thoracic Disease
Marie Sauvadet, Karel Van den Meersche, Clémentine Allinne, Fréderic Gay, Elias de Melo Virginio Filho, Matthieu Chauvat, Thierry Becquer, Philippe Tixier, Jean-Michel Harmand
Conventional, intensively managed coffee plantations are currently facing environmental challenges. The use of shade trees and the organic management of coffee crops are welcome alternatives, aiming to reduce synthetic inputs and restore soil biological balance. However, little is known about the impacts of the different types of shade tree species on soil functioning and fauna. In this paper, we assess soil nutrient availability and food web structure on a 17-year old experimental coffee plantation in Turrialba in Costa Rica...
February 1, 2019: Science of the Total Environment
Tina Zimmermann, Mattia Maroso, Annika Beer, Sarah Baddenhausen, Susann Ludewig, Wenqiang Fan, Constance Vennin, Sebastian Loch, Benedikt Berninger, Clementine Hofmann, Martin Korte, Ivan Soltesz, Beat Lutz, Julia Leschik
Neural stem cells (NSCs) in the adult mouse hippocampus occur in a specific neurogenic niche, where a multitude of extracellular signaling molecules converges to regulate NSC proliferation as well as fate and functional integration. However, the underlying mechanisms how NSCs react to extrinsic signals and convert them to intracellular responses still remains elusive. NSCs contain a functional endocannabinoid system, including the cannabinoid type-1 receptor (CB1). To decipher whether CB1 regulates adult neurogenesis directly or indirectly in vivo, we performed NSC-specific conditional inactivation of CB1 by using triple-transgenic mice...
October 11, 2018: Cerebral Cortex
Monique Le Ret, Susan Belcher, Stefanie Graindorge, Clémentine Wallet, Sandrine Koechler, Mathieu Erhardt, Rosalind Williams-Carrier, Alice Barkan, José Manuel Gualberto
Thymidine kinase (TK) is a key enzyme of the salvage pathway that recycles thymidine nucleosides to produce dTTP. We identified the single TK of maize, denoted CPTK1, as an essential factor in the replication of the plastidial genome (cpDNA), demonstrating the essential function of the salvage pathway during chloroplast biogenesis. CPTK1 localizes to both plastids and mitochondria. Its absence results in an albino phenotype, reduced cpDNA copy number, and a severe deficiency for plastidial ribosomes. No significant effect was found on mitochondria, indicating that they are less reliant on the salvage pathway...
October 10, 2018: Plant Physiology
Laure Delhon, Clémentine Mahaut, Nicolas Goudin, Emilie Gaudas, Kevin Piquand, Wilfried Le Goff, Valérie Cormier-Daire, Carine Le Goff
Mutations in the a disintegrin and metalloproteinase with thrombospondin motif-like 2 ( ADAMTSL2) gene are responsible for the autosomal recessive form of geleophysic dysplasia, which is characterized by short stature, short extremities, and skeletal abnormalities. However, the exact function of ADAMTSL2 is unknown. To elucidate the role of this protein in skeletal development, we generated complementary knockout (KO) mouse models with either total or chondrocyte Adamtsl2 deficiency. We observed that the Adamtsl2 KO mice displayed skeletal abnormalities reminiscent of the human phenotype...
October 10, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Clémentine Montagnac, Carole Eldin, Anais Thouret, Stéphane Ranque, Philippe Brouqui
No abstract text is available yet for this article.
October 6, 2018: Travel Medicine and Infectious Disease
Jivan Khlghatyan, Clémentine Quintana, Martin Parent, Jean-Martin Beaulieu
Cortical D2 dopamine receptor (Drd2) have mostly been examined in the context of cognitive function regulation and neurotransmission modulation of medial prefrontal cortex by principal neurons and parvalbumin positive, fast-spiking, interneurons in schizophrenia. Early studies suggested the presence of D2 receptors in several cortical areas, albeit with major technical limitations. We used combinations of transgenic reporter systems, recombinase activated viral vectors, quantitative translatome analysis, and high sensitivity in situ hybridization to identify D2 receptor expressing cells and establish a map of their respective projections...
October 6, 2018: Cerebral Cortex
Marlene K Haggblade, Woutrina A Smith, Jean Bosco Noheri, Clementine Usanase, Antoine Mudakikwa, Michael R Cranfield, Kirsten V K Gilardi
Mountain gorillas ( Gorilla beringei beringei) are one of the most critically endangered great apes in the world. The most common cause of mountain gorilla morbidity and mortality is trauma (e.g., injury from conspecifics or snare entrapment). We conducted a retrospective case-control study of free-ranging, human-habituated mountain gorillas to evaluate factors associated with snare entrapment and the results of clinical intervention. Data were collected from clinical records on all clinical intervention cases ( n=132) in Volcanoes National Park, Rwanda, conducted between 1995-2015...
October 4, 2018: Journal of Wildlife Diseases
Nora H Prior, Marie S A Fernandez, Hédi A Soula, Clémentine Vignal
Although steroids are widely known to affect behavior through activation of nuclear/cytosolic receptors ("genomic" effects), steroids can also rapidly affect behavior via modulation of signal transduction pathways ("nongenomic," fast actions, or rapid effects). In zebra finches, there is evidence that sex steroids have context-specific effects on pair-maintenance behavior, on both acute and chronic timescales. Here, we quantified the effects of orally administered testosterone and 17β-estradiol (E2) on pair-maintenance behavior...
October 4, 2018: Behavioral Neuroscience
François Lemonnier, Jehan Dupuis, Pierre Sujobert, Olivier Tournillhac, Morgane Cheminant, Clémentine Sarkozy, Laura Pelletier, Ambroise Marçais, Cyrielle Robe, Virginie Fataccioli, Corinne Haioun, Olivier Hermine, Philippe Gaulard, Richard Delarue
No abstract text is available yet for this article.
October 2, 2018: Blood
Clémentine Le Magnen, Renu K Virk, Aditya Dutta, Jaime Yeji Kim, Sukanya Panja, Zoila A Lopez-Bujanda, Andrea Califano, Charles G Drake, Antonina Mitrofanova, Cory Abate-Shen
While it is known that inflammation plays a critical role in prostate tumorigenesis, the underlying processes are not well understood. Based on analysis of genetically-engineered mouse models combined with correlative analysis of expression profiling data from human prostate tumors, we demonstrate a reciprocal relationship between inflammation and the status of the NKX3.1 homeobox gene associated with prostate cancer initiation. We find that cancer initiation in aged Nkx3.1 mutant mice correlates with enrichment of specific immune populations and increased expression of immunoregulatory genes...
September 28, 2018: Disease Models & Mechanisms
Nathanaëlle Saclier, Clémentine M François, Lara Konecny-Dupré, Nicolas Lartillot, Laurent Guéguen, Laurent Duret, Florian Malard, Christophe J Douady, Tristan Lefébure
The rate of molecular evolution varies widely among species. Life history traits have been proposed as a major driver of these variations. However, the relative contribution of each trait is poorly understood. Here, we test the influence of metabolic rate, longevity and generation time on the nuclear and mitochondrial synonymous substitution rates using a group of isopod species that have made multiple independent transitions to subterranean environments. Subterranean species have repeatedly evolved a lower metabolic rate, a longer lifespan and a longer generation time...
September 24, 2018: Molecular Biology and Evolution
Clémentine Puech, Sophie Hodin, Valérie Forest, Zhiguo He, Patrick Mismetti, Xavier Delavenne, Nathalie Perek
Endothelial cells are main components of the Blood-Brain Barrier (BBB) and form a tight monolayer that regulates the passage of molecules, with the ATP-Binding Cassette (ABC) transporters efflux pumps. We have developed a human in vitro model of HBEC-5i endothelial cells cultivated alone or with human astrocytes conditioned medium on insert. HBEC-5i cells showed a tight monolayer within 14 days, expressing ZO-1 and claudin 5, a low apparent permeability to small molecules, with a TEER stability during five days...
November 15, 2018: International Journal of Pharmaceutics
Candice Bulke, Clémentine Gondolf, Frédérique Grandhomme, Stéphane Allouche
Glycated hemoglobin A1c (HbA1c) reflects the mean blood glucose over the lifespan of red blood cells and has become a valuable tool both for diagnosis and monitoring of diabetes. Nevertheless, some factors may under-estimate the HbA1c value, compromising its application. The aim of this retrospective study was to evaluate the incidence rate of HbA1c lower than 4% and to identify some clinical and biological factors that can potentially reduce the HbA1c level. Between January 1st 2015 and October 1st 2017, we selected 17 patients with a HbA1c level lower than 4% that were measured in our laboratory of biochemistry at the university medical center of Caen...
October 1, 2018: Annales de Biologie Clinique
Clementine L Chambon, Thandeka Y Mkhize, Prashant Reddy, Agnieszka Brandt-Talbot, Nirmala Deenadayalu, Paul S Fennell, Jason P Hallett
Background: Sugarcane bagasse is an abundant and geographically widespread agro-industrial residue with high carbohydrate content, making it a strong candidate feedstock for the bio-based economy. This study examines the use of the low-cost protic ionic liquid triethylammonium hydrogen sulfate ([TEA][HSO4 ]) to fractionate a range of South African sugarcane bagasse preparations into a cellulose-rich pulp and lignin. The study seeks to optimize pretreatment conditions and examine the necessity of applying a depithing step on bagasse prior to pretreatment...
2018: Biotechnology for Biofuels
Clémentine Sarkozy, Laurie H Sehn
Diffuse large B cell lymphoma represents the most common type of non-Hodgkin lymphoma. Although the curability rate is high, around 40% of patients will relapse or exhibit refractory disease. To obtain long-term disease-free survival after relapse, an intensive salvage regimen followed by autologous steam cell transplant remains the standard of care. However, more than 60% of patients will be transplant ineligible, presenting a therapeutic challenge. In this setting, there is no definitive standard approach, as management should be individualized according to patient tolerance...
September 2018: Best Practice & Research. Clinical Haematology
Clémentine Gandilhon, Patricia Soler-Michel, Léa Vecchiato, Claude Chaunier, Isabelle Fay, Thomas Walter, Jérôme Rivory, Jean-Christophe Saurin, Thierry Ponchon, Mathieu Pioche
BACKGROUND: A large proportion of individuals with a positive faecal immunologic test (FIT) will never undergo the recommended colonoscopy despite a full sequence of reminders. AIMS: This prospective study aimed to recruit refractory individuals by a motivational personalised phone call given by a screening physician. METHODS: We evaluated the impact of a motivational phone call given by a physician of the screening organisation in order to convince patients with positive FIT to undergo a colonoscopy...
August 17, 2018: Digestive and Liver Disease
Mathilde Boulanger, Séverine Tual, Clémentine Lemarchand, Anne-Valérie Guizard, Patricia Delafosse, Elisabeth Marcotullio, Romain Pons, Clément Piel, Camille Pouchieu, Isabelle Baldi, Bénédicte Clin, Pierre Lebailly
OBJECTIVES: Farmers are considered at lower risk of lung cancer. However, specific tasks can expose them to hazardous air contaminants such as pesticides, diesel exhaust and mineral dust. This study aimed to assess the associations between various crops and related tasks and the risk of lung cancer, overall and by histological subtypes. METHODS: AGRIculture and CANcer is a prospective French cohort of individuals affiliated to the agricultural health insurance scheme...
September 5, 2018: Occupational and Environmental Medicine
Eglantine Hamouni, Corinne Armari, Clémentine Dupuis, Claudine Giroux-Lathuile, Audrey Petit, Dominique Plantaz, Dalila Adjaoud, Amandine Rubio
Beta thalassemia major (βTM) is the most common inherited hemoglobinopathy. Management essentially focuses on preventing and treating complications. Conventional treatment is based on a regular blood transfusion program, and chelation therapy. Management essentially focuses on preventing and treating complications. Severe complications of βTM are very rarely seen in children in Europe. In the context of the migrant crisis, pediatricians will be confronted with the challenge of managing severe complicated βTM...
August 31, 2018: Journal of Pediatric Hematology/oncology
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