George Vasquez-Rios, Wonsuk Oh, Samuel Lee, Pavan Bhatraju, Sherry G Mansour, Dennis G Moledina, Faris F Gulamali, Edward D Siew, Amit X Garg, Pinaki Sarder, Vernon M Chinchilli, James S Kaufman, Chi-Yuan Hsu, Kathleen D Liu, Paul L Kimmel, Alan S Go, Mark M Wurfel, Jonathan Himmelfarb, Chirag R Parikh, Steven G Coca, Girish N Nadkarni
BACKGROUND: AKI is a heterogeneous syndrome. Current subphenotyping approaches have only used limited laboratory data to understand a much more complex condition. METHODS: We focused on patients with AKI from the Assessment, Serial Evaluation, and Subsequent Sequelae in AKI (ASSESS-AKI). We used hierarchical clustering with Ward linkage on biomarkers of inflammation, injury, and repair/health. We then evaluated clinical differences between subphenotypes and examined their associations with cardiorenal events and death using Cox proportional hazard models...
June 1, 2023: Clinical Journal of the American Society of Nephrology: CJASN