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https://www.readbyqxmd.com/read/29793116/patterns-of-invasive-growth-in-malignant-gliomas-the-hippocampus-emerges-as-an-invasion-spared-brain-region
#1
Awais A Mughal, Lili Zhang, Artem Fayzullin, Andres Server, Yuping Li, Yingxi Wu, Rainer Glass, Torstein Meling, Iver A Langmoen, Trygve B Leergaard, Einar O Vik-Mo
BACKGROUND: Widespread infiltration of tumor cells into surrounding brain parenchyma is a hallmark of malignant gliomas, but little data exist on the overall invasion pattern of tumor cells throughout the brain. METHODS: We have studied the invasive phenotype of malignant gliomas in two invasive mouse models and patients. Tumor invasion patterns were characterized in a patient-derived xenograft mouse model using brain-wide histological analysis and magnetic resonance (MR) imaging...
May 21, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29792518/it-is-the-family-context-that-matters-concurrent-and-predictive-effects-of-aspects-of-parent-child-interaction-on-video-gaming-related-problems
#2
Angel Yee-Lam Li, Barbara Chuen-Yee Lo, Cecilia Cheng
Studies have shown that children frequently experiencing poor parent-child interaction are prone to video gaming-related problems, but it is unclear which specific aspects of such an interaction play a predictive role in the problems. To extend previous research that relies primarily on the self-report method to assess parent-child interaction, we conducted a longitudinal, mixed-methods study. In a laboratory setting, three major aspects of interaction (i.e., affectivity, cohesiveness, and parental behavior) were observed in 241 parent-child dyads (Children: 43 percent female, age range = 8-15, Mage  = 12...
May 24, 2018: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/29792136/zinc-dependent-histone-deacetylase-inhibitors-in-cancer-therapeutics-recent-update
#3
Panagiotis I Georgianos, Maria Divani, Theodoros Eleftheriadis, Peter R Mertens, Vassilios Liakopoulos
BACKGROUND: Despite optimal management of diabetic kidney disease (DKD) with intensive glycemic control and administration of agents blocking the renin-angiotensin-aldosterone-system, the residual risk for nephropathy progression to end-stage-renal-disease (ESRD) remains high. Sodium-glucose co-transporter type 2 (SGLT-2)-inhibitors represent a newly-introduced anti-diabetic drug class with pleiotropic actions extending above their glucose-lowering efficacy. Herein, we provide an overview of preclinical and clinical-trial evidence supporting a protective effect of SGLT-2 inhibitors on DKD...
May 23, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29792135/modified-ldl-immune-complexes-and-cardiovascular-disease
#4
Maria F Lopes-Virella, Gabriel Virella
Modified forms of LDL, both spontaneously formed in the organism or prepared in the laboratory, are immunogenic. As a consequence, antigen-antibody complexes (immune complexes, IC) formed in vivo can be measured in the peripheral blood, and their levels are strong predictors of cardiovascular disease (CVD). It has been possible to generate antibodies that recognize different LDL modifications, allowing the analysis of circulating IC constitution. Clinical studies showed that the antigenic constitution of the IC has a modulating effect on the development of CVD...
May 23, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29791697/total-laparoscopic-hysterectomy-in-the-setting-of-prior-bilateral-renal-transplant-a-case-report-and-review-of-the-literature
#5
Nupur Tamhane, Entidhar Al Sawah, Emad Mikhail
In recent years, more women are undergoing renal transplantation as a treatment for end-stage renal disease. Women with kidney transplants are prone to certain gynecologic issues which might necessitate hysterectomy. Laparoscopic hysterectomy can safely be performed in patients with prior unilateral or bilateral renal transplantation. Laparoscopy offers magnification of anatomy, decreased wound-related problems, and continuation of immunosuppression therapy. We present a case report and review of the literature for total laparoscopic hysterectomy and bilateral salpingectomy for a patient with prior bilateral renal transplant...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791248/ddy-mice-fed-10-fat-diet-exhibit-high-p27kip-expression-and-delayed-hepatocyte-dna-synthesis-during-liver-regeneration
#6
Yohei Saito, Yoshikazu Kuwahara, Yumi Yamamoto, Masatoshi Suzuki, Manabu Fukumoto, Fumihiko Yamamoto
BACKGROUND: Excessive intake of a high-calorie diet has been implicated in the development of non-alcoholic fatty liver disease (NAFLD). Several studies have investigated the effect of NAFLD on liver regeneration, but the effects of simple steatosis have been found to be inconsistent. We aimed to assess whether the initial phase of diet-induced lipid accumulation, induced by a diet containing moderate levels of fat, impairs liver regeneration after partial hepatectomy (PHx) of mice. METHODS: Male ddY mice are prone to obesity, even when fed a relatively low-fat diet (FD)...
May 23, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29790701/the-clinical-importance-of-changes-in-treg-and-th17-lymphocyte-subsets-in-splenectomized-patients-after-spleen-injury
#7
Witold Zgodziński, Ewelina Grywalska, Dorota Siwicka-Gieroba, Agata Surdacka, Krzysztof Zinkiewicz, Dariusz Szczepanek, Grzegorz Wallner, Jacek Roliński
BACKGROUND: Splenectomized patients are more prone to bacterial infections due to their immunocompromised status. Little is known about the role of T helper 17 (Th17) and T regulatory cells (Treg) in the immune system of patients after the removal of the spleen. OBJECTIVES: The aim of the present study was to analyze possible changes in CD4+ lymphocyte T subsets, especially Treg and Th17, in patients who had undergone splenectomy. MATERIAL AND METHODS: The study included a group of 67 male patients (41...
May 22, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790367/are-hydroethidine-based-probes-reliable-for-ros-detection
#8
Yi Xiao, David Meierhofer
Detection and quantification of the highly reactive and short lived superoxide (O·2-) can be challenging. Here, we present a new mass spectrometry (MS)-based method to detect and quantify O·2- using three fluorogenic hydroethidine probes: HE, mito-HE, and HPr+, which measure cytosolic, mitochondrial and extracellular O·2-, respectively. The probes and their oxidation products were simultaneously quantified by applying multiple reaction monitoring (MRM) with mass spectrometry that allowed the specific measurement of ROS distribution within the cell...
May 23, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29790144/-prone-position-and-nursing-care
#9
Shu-Ju Lu, Shiao-Pei Wang
Acute respiratory distress syndrome (ARDS) is a life-threatening disease, as acute inflammation in the lungs typically leads to hypoxia and symptoms of dyspnea. The treatment modalities of ARDS include mechanical ventilation, corticosteroid, extracorporeal membranous oxygenation, inhaled nitrogen oxide, and the prone position. Among these, the prone position is supported by evidence showing significantly reduced mortality in patients that adopt this modality. Lying in the prone position reduces atelectatic lung volumes by recruitment of dependent parts and facilitates normal regulation of alveolar ventilation, giving better-matched ventilation perfusion and, thus, improved oxygenation...
June 2018: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29789820/structural-mechanisms-of-oligomer-and-amyloid-fibril-formation-by-the-prion-protein
#10
Ishita Sengupta, Jayant B Udgaonkar
Misfolding and aggregation of the prion protein is responsible for multiple neurodegenerative diseases. Works from several laboratories on folding of both the WT and multiple pathogenic mutant variants of the prion protein have identified several structurally dissimilar intermediates, which might be potential precursors to misfolding and aggregation. The misfolded aggregates themselves are morphologically distinct, critically dependent on the solution conditions under which they are prepared, but always β-sheet rich...
May 23, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29789721/is-leptin-resistance-the-cause-or-the-consequence-of-diet-induced-obesity
#11
Kathy C G de Git, Céline Peterse, Sanne Beerens, Mieneke C M Luijendijk, Geoffrey van der Plasse, Susanne E la Fleur, Roger A H Adan
BACKGROUND/OBJECTIVES: Obesity is strongly associated with leptin resistance. It is unclear whether leptin resistance results from the (over)consumption of energy-dense diets or if reduced leptin sensitivity is also a pre-existing factor in rodent models of diet-induced obesity (DIO). We here tested whether leptin sensitivity on a chow diet predicts subsequent weight gain and leptin sensitivity on a free choice high-fat high-sucrose (fcHFHS) diet. METHODS: Based upon individual leptin sensitivity on chow diet, rats were grouped in leptin sensitive (LS, n = 22) and leptin resistant (LR, n = 19) rats (P = 0...
May 22, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29789497/treating-p53-mutant-aggregation-associated-cancer
#12
REVIEW
Mathumai Kanapathipillai
p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth. Recent studies show correlation between p53 mutant aggregation, functional loss, and tumor growth...
May 23, 2018: Cancers
https://www.readbyqxmd.com/read/29789202/relationship-between-prolonged-neural-suppression-and-cerebral-hemodynamic-dysfunction-during-hypothermia-in-asphyxiated-piglets
#13
Wataru Jinnai, Shinji Nakamura, Kosuke Koyano, Satoshi Yamato, Takayuki Wakabayashi, Yinmon Htun, Yasuhiro Nakao, Takashi Iwase, Makoto Nakamura, Saneyuki Yasuda, Masaki Ueno, Takanori Miki, Takashi Kusaka
OBJECTIVES: Hypothermia (HT) improves the outcome of neonatal hypoxic-ischemic encephalopathy. Here, we investigated changes during HT in cortical electrical activity using amplitude-integrated electroencephalography (aEEG) and in cerebral blood volume (CBV) and cerebral hemoglobin oxygen saturation using near-infrared time-resolved spectroscopy (TRS) and compared the results with those obtained during normothermia (NT) after a hypoxic-ischemic (HI) insult in a piglet model of asphyxia...
May 19, 2018: Brain & Development
https://www.readbyqxmd.com/read/29789091/spinal-stiffness-in-prone-and-upright-postures-during-0-1-8-g-induced-by-parabolic-flight
#14
Jaap Swanenburg, Michael L Meier, Anke Langenfeld, Petra Schweinhardt, B Kim Humphreys
INTRODUCTION: The purpose of this study was to analyze posterior-to-anterior spinal stiffness in Earth, hyper-, and microgravity conditions during both prone and upright postures. CASE REPORT: During parabolic flight, the spinal stiffness of the L3 vertebra of a healthy 37-yr-old man was measured in normal Earth gravity (1.0 g), hypergravity (1.8 g), and microgravity (0.0 g) conditions induced in the prone and upright positions. Differences in spinal stiffness were significant across all three gravity conditions in the prone and upright positions...
June 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29788779/elevated-serum-lipid-peroxidation-and-reduced-vitamin-c-and-trace-element-concentrations-are-correlated-with-epilepsy
#15
Abhijit Das, Md Shahid Sarwar, Md Shohel Hossain, Palash Karmakar, Mohammad Safiqul Islam, Mohammad Enayet Hussain, Sujan Banik
BACKGROUND: Epilepsy is one of the chronic and heterogeneous epidemic neurological disorders leading to substantial mortality. The aim of the present study was to investigate the serum levels of malondialdehyde (MDA), vitamin C, and trace elements namely zinc (Zn), copper (Cu), and manganese (Mn) in epileptic patients of Bangladesh and to establish if there are any pathophysiological correlations. METHODS: This was a case-control study with 40 generalized epileptic patients and 40 healthy subjects as controls...
May 1, 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29788154/macrovascular-decompression-of-facial-nerve-with-anteromedial-transposition-of-a-dolichoectatic-vertebral-artery-3-dimensional-operative-video
#16
Halima Tabani, Sonia Yousef, Jan-Karl Burkhardt, Sirin Gandhi, Arnau Benet, Michael T Lawton
Most cranial nerve compression syndromes (ie, trigeminal neuralgia and hemifacial spasm) are caused by small arteries impinging on a nerve and are relieved by microvascular decompression. Rarely, cranial nerve compression syndromes can be caused by large artery impingement and can be relieved by macrovascular decompression. When present, this compression often occurs in association with degenerative atherosclerosis in the vertebral arteries (VA) and basilar artery. Conservative treatment is recommended for mild forms, but surgical transposition of the VA away from the root entry zone (REZ) can be considered...
May 21, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29787777/examination-of-the-effects-of-cannabinoid-ligands-on-decision-making-in-a-rat-gambling-task
#17
Jacqueline-Marie N Ferland, Madison Carr, Angela M Lee, Myrthe E Hoogeland, Catharine A Winstanley, Tommy Pattij
Although exposure to delta-9-tetrahydrocannabinol (THC) is perceived to be relatively harmless, mounting evidence has begun to show that it is associated with a variety of cognitive deficits, including poor decision making. THC-induced impairments in decision making are thought to be the result of cannabinoid CB1 receptor activation, and although clinical literature suggests that chronic activation via THC contributes to perturbations in decision making, acute CB1 receptor modulation has yielded mixed results...
May 19, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29787584/method-overtness-forensic-autopsy-and-the-evidentiary-suicide-note-a-multilevel-national-violent-death-reporting-system-analysis
#18
Ian R H Rockett, Eric D Caine, Steven Stack, Hilary S Connery, Kurt B Nolte, Christa L Lilly, Ted R Miller, Lewis S Nelson, Sandra L Putnam, Paul S Nestadt, Haomiao Jia
OBJECTIVE: Higher prevalence of suicide notes could signify more conservatism in accounting and greater proneness to undercounting of suicide by method. We tested two hypotheses: (1) an evidentiary suicide note is more likely to accompany suicides by drug-intoxication and by other poisoning, as less violent and less forensically overt methods, than suicides by firearm and hanging/suffocation; and (2) performance of a forensic autopsy attenuates any observed association between overtness of method and the reported presence of a note...
2018: PloS One
https://www.readbyqxmd.com/read/29787441/exome-sequencing-discloses-ionizing-radiation-induced-dna-variants-in-the-genome-of-human-gingiva-fibroblasts
#19
Neetika Nath, Jennifer Esche, Jessica Müller, Lars R Jensen, Matthias Port, Mario Stanke, Lars Kaderali, Harry Scherthan, Andreas W Kuss
Ionizing radiation can induce genomic lesions such as DNA double-strand breaks whose incomplete or faulty repair can result in mutations, which in turn can influence cellular functions and alter the fate of affected cells and organ systems. Ionizing-radiation-induced sequence alterations/mutations occur in a stochastic manner, which contributes to an increased cancer risk in irradiated individuals. Ionizing radiation exposure, and particularly acute doses at high dose rates (as often observed in radiation accidents), induce alterations in the genome that in part will reflect specific characteristics of the DNA damage response and the repair mechanisms involved...
July 2018: Health Physics
https://www.readbyqxmd.com/read/29787435/nhej-contributes-to-the-fast-repair-of-radiation-induced-dna-double-strand-breaks-at-late-prophase-i-telomeres
#20
Emad A Ahmed, Michael Rosemann, Harry Scherthan
Exposure of cells to ionizing radiation induces DNA double-strand breaks. To repair double-strand breaks correctly, cells must distinguish between the ends of chromosomes (telomeres) and DNA double-strand breaks within chromosomes. Double-strand breaks in telomeric DNA may lead to telomere shortening and mutagenesis. Eukaryotic cells repair double-strand breaks primarily by two mechanisms: error-free homologous recombination and error-prone nonhomologous end joining, of which homologous recombination is used in early meiotic prophase I to create recombined haploid gametes by two meiotic cell divisions lacking an intervening S-phase...
July 2018: Health Physics
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