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https://www.readbyqxmd.com/read/30121427/chemical-and-genomic-diversity-of-six-lonicera-species-occurring-in-korea
#1
Kyo Bin Kang, Shin-Jae Kang, Mi Song Kim, Dong Young Lee, Sang Il Han, Tae Bum Kim, Jee Young Park, Jinwoong Kim, Tae-Jin Yang, Sang Hyun Sung
Lonicera spp. (Caprifoliaceae) are important not only as a common medicinal herb in East Asia but also as one of the most problematic invasive species in North America. In the present study, we performed a systemic analysis of genomic and chemical diversity among six Lonicera species occurring in Korea, L. japonica, L. maackii, L. insularis, L. sachalinensis, L. praeflorens, and L. vesicaria, using chloroplast DNA whole genome shotgun (WGS) sequencing and LC-MS analyses. The phylogenetic and phylochemical relationships did not coincide with each other, but partial consistency could be found among them...
August 16, 2018: Phytochemistry
https://www.readbyqxmd.com/read/30111623/how-to-determine-the-role-of-the-microbiome-in-drug-disposition
#2
Jordan E Bisanz, Peter Spanogiannopoulos, Lindsey M Pieper, Annamarie E Bustion, Peter J Turnbaugh
With a paradigm shift occurring in health care towards personalized and precision medicine, understanding the numerous environmental factors that impact drug disposition is of paramount importance. The highly diverse and variant nature of the human microbiome is now recognized as a factor driving inter-individual variation in therapeutic outcomes. The purpose of this review is to provide a practical guide on methodology that can be applied to study the effects of microbes on the absorption, distribution, metabolism, and excretion of drugs...
August 15, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/30111052/-genetic-diversity-of-6-species-in-polygonatum-by-ssr-marker
#3
Qiao Zhu, Xin Deng, Shu-Bing Zhang, Shi-Yong Mei, Xiao-Jun Chen, Ji-Fang Zhang, Qing-Ming Xiao, Yu Li
Polygonatum is a genus of the perennial herb family Liliaceae, with great potential in food, medicine and other field. In this study, genetic diversity and cluster structure analysis of 6 species in Polygonatum were investigated the molecular marker technique of simple sequence repeat (SSR). A total of 49 SSR makers were used to study genetic diversity and population structure within 60 germplasm resources which obtained from 38 counties and cities in 14 provinces of China. A total of 211 alleles were identified and the number of alleles ranged from 2 to 10, with an average of 4...
July 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/30101517/a-rapid-and-sensitive-method-for-the-quantitative-analysis-of-ibuprofen-and-its-metabolites-in-equine-urine-samples-by-gas-chromatography-tandem-mass-spectrometry
#4
Emilia Waraksa, Mateusz Kacper Woźniak, Ewa Kłodzińska, Robert Wrzesień, Barbara Bobrowska-Korczak, Jacek Namieśnik
Ibuprofen is widely used in human and veterinary medicine for the treatment of chronic pain as well as rheumatic and musculoskeletal disorders. However, the analgesic and anti-inflammatory properties of Ibuprofen have contributed to frequent drug abuse in equestrian sports. A sensitive and rapid GC-MS/MS-based method with a simple liquid-liquid extraction and derivatization requiring 200 μL volume of sample and 2 mL of extraction solvent for the simultaneous determination of ibuprofen and its metabolites was developed...
August 12, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/30100566/facilitators-of-interdepartmental-quality-improvement-a-mixed-methods-analysis-of-a-collaborative-to-improve-pediatric-community-acquired-pneumonia-management
#5
JoAnna K Leyenaar, Christine B Andrews, Emily R Tyksinski, Eric Biondi, Kavita Parikh, Shawn Ralston
BACKGROUND: Emergency medicine and paediatric hospital medicine physicians each provide a portion of the initial clinical care for the majority of hospitalised children in the USA. While these disciplines share goals to increase quality of care, there are scant data describing their collaboration. Our national, multihospital learning collaborative, which aimed to increase narrow-spectrum antibiotic prescribing for paediatric community-acquired pneumonia, provided an opportunity to examine factors influencing the success of quality improvement efforts across these two clinical departments...
August 12, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/30094720/expression-of-lc3b-and-fip200-atg17-in-brain-metastases-of-breast-cancer
#6
Nooshin Hashemi-Sadraei, Gaëlle M Müller-Greven, Fadi W Abdul-Karim, Ilya Ulasov, Erinn Downs-Kelly, Monica E Burgett, Adam Lauko, Maha A Qadan, Robert J Weil, Manmeet S Ahluwalia, Lingling Du, Richard A Prayson, Samuel T Chao, Thomas G Budd, Jill Barnholtz-Sloan, Amy S Nowacki, Ruth A Keri, Candece L Gladson
BACKGROUND: Macroautophagy/autophagy is considered to play key roles in tumor cell evasion of therapy and establishment of metastases in breast cancer. High expression of LC3, a residual autophagy marker, in primary breast tumors has been associated with metastatic disease and poor outcome. FIP200/Atg17, a multi-functional pro-survival molecule required for autophagy, has been implicated in brain metastases in experimental models. However, expression of these proteins has not been examined in brain metastases from patients with breast cancer...
August 9, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/30091416/the-role-of-vascular-endothelial-growth-factor-in-systemic-sclerosis
#7
Victoria A Flower, Shaney L Barratt, Stephen Ward, John D Pauling
The pathological hallmarks of Systemic sclerosis (SSc) constitute an inter-related triad of autoimmunity, vasculopathy and tissue remodeling. Many signaling mediators have been implicated in SSc pathology; most focusing on individual components of this pathogenic triad and current treatment paradigms tend to approach management of such as distinct entities. The present review shall examine the role of vascular endothelial growth factor (VEGF) in SSc pathogenesis. We shall outline potential mechanisms whereby differential vascular endothelial growth factor-A (VEGF-A) isoform expression (through conventional and alternative VEGF-A splicing,) may influence the relevant burden of vasculopathy and fibrosis offering novel insight into clinical heterogeneity and disease progression in SSc...
August 9, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/30085679/inter-species-developmental-differences-in-metabonomic-phenotypes-of-lycium-ruthenicum-and-l-barbarum-fruits
#8
Qi Wang, Shaohua Zeng, Xiangyu Wu, Hehua Lei, Ying Wang, Huiru Tang
Fruits of Lycium ruthenicum (LR) and L. barbarum (LB) in Solanaceae family contain abundant bioactive metabolites used widely as functional food and natural medicine. To characterize the fruit developmental molecular phenotypes, we comprehensively analyzed metabolite composition of both Lycium fruits at three developmental stages using the combined NMR, LC-MS/MS and GC-FID/MS methods. The metabonomes of these fruits were dominated by over 90 metabolites including sugars, amino acids, TCA cycle intermediates, fatty acids, choline metabolites and shikimate-mediated plant secondary metabolites...
August 7, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/30081898/capacity-of-ugandan-public-sector-health-facilities-to-prevent-and-control-non-communicable-diseases-an-assessment-based-upon-who-pen-standards
#9
Hilary E Rogers, Ann R Akiteng, Gerald Mutungi, Adrienne S Ettinger, Jeremy I Schwartz
BACKGROUND: Non-communicable diseases (NCDs) are increasing in prevalence in low-income countries including Uganda. The Uganda Ministry of Health has prioritized NCD prevention, early diagnosis, and management. However, research on the capacity of public sector health facilities to address NCDs is limited. METHODS: We developed a survey guided by the literature and the standards of the World Health Organization Pacakage of Essential Noncommunicable Disease Interventions for Primary Health Care in Low-Resource Settings...
August 6, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/30067128/isoflurane-and-ketamine-differentially-influence-spontaneous-and-evoked-laminar-electrophysiology-in-mouse-v1
#10
Nicholas J Michelson, Takashi Daniel Yoshida Kozai
General anesthesia is ubiquitous in research and medicine, yet although the molecular mechanisms of anesthetics are well characterized, their ultimate influence on cortical electrophysiology remains unclear. Moreover, the influence that different anesthetics have on sensory cortices at neuronal and ensemble scales is mostly unknown, and represents an important gap in knowledge that has widespread relevance for neural sciences. To address this knowledge gap, this work explored the effects of isoflurane and ketamine/xylazine, two widely used anesthetic paradigms, on electrophysiological behavior in mouse primary visual cortex...
August 1, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/30051090/editorial-processes-in-free-open-access-medical-educational-foam-resources
#11
Arden Azim, Jennifer Beck-Esmay, Teresa M Chan
Background: Much of the skepticism toward online educational resources (OERs) in emergency medicine (EM) stems from the low barrier to publishing and a perceived lack of editorial rigor. Learners and educators have demonstrated unreliable gestalt ratings of OERs, suggesting a lack of capacity to consistently appraise these resources. The development of tools to guide clinicians and learners in the selection and use of blogs and podcasts is a growing area of interest. Disclosure of editorial process was identified in previous studies as an important quality indicator for OERs...
July 2018: AEM education and training
https://www.readbyqxmd.com/read/30051053/the-council-of-emergency-medicine-residency-directors-speaker-evaluation-form-for-medical-conference-planners
#12
Andrew W Phillips, David Diller, Sarah Williams, Yoon Soo Park, Jonathan Fisher, Kevin Biese, Jacob Ufberg
Objectives: No summative speaker evaluation form with validity and reliability evidence currently exists in the English medical education literature specifically to help conference planners make future decisions on speakers. We seek to perform a proof-of-concept evaluation of a concise, effective evaluation form to be filled out by audience members to aid conference planners. Methods: We created the Council of Emergency Medicine Residency Directors (CORD-EM) form, a novel, three-question speaker evaluation form for the CORD-EM national conference and evaluated it for proof of concept...
October 2017: AEM education and training
https://www.readbyqxmd.com/read/30048897/simultaneous-determination-of-fourteen-compounds-of-hedyotis-diffusa-willd-extract-in-rats-by-uhplc-ms-ms-method-application-to-pharmacokinetics-and-tissue-distribution-study
#13
Xiaoqing Chen, Pingchuan Zhu, Buming Liu, Liuting Wei, Yuanjin Xu
A rapid, sensitive and selective ultra high-performance liquid chromatography-tandem mass spectrometry UHPLC-MS/MS method has been developed and validated for the simultaneous determination of fourteen bioactive ingredients (gallic acid, geniposidic acid, protocatechuic acid, caffeic acid, ferulic acid, scopoletin, apigenin-7-o-glucuronide, daidzein, apigenin, ursolic acid, oleanolic acid, β-sitosterol, coniferin, and stigmasterol) in the plasma and tissues of rats. Danshensu and icariin were used as internal standards (IS1 and IS2)...
July 18, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/30048731/effects-of-baoyuan-decoction-a-traditional-chinese-medicine-formula-on-the-activities-and-mrna-expression-of-seven-cyp-isozymes-in-rats
#14
Ying-Yuan Lu, Zhi-Yong Du, Yan Li, Jin-Long Wang, Ming-Bo Zhao, Yong Jiang, Xiao-Yu Guo, Peng-Fei Tu
ETHNOPHARMACOLOGICAL RELEVANCE: Baoyuan decoction (BYD), a traditional Chinese medicine (TCM) formula, is composed of four herbs and widely used with western drugs to treat coronary heart disease, aplastic anemia and chronic renal failure in clinic. However, no study of the effect of BYD on the cytochrome P450 (CYP) activities has been reported. AIM OF THE STUDY: The purpose of the present study was to evaluate the potential influences of BYD on the activities of seven CYP isozymes (CYP1A2, 2B6, 2C9, 2C19, 2D6, 2E1, and 3A4) in rats...
October 28, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30042802/reorganising-health-and-social-care-in-qu%C3%A3-bec-a-journey-towards-integrating-care-through-mergers
#15
Paul Wankah, Maxime Guillette, Sophie Dumas, Yves Couturier, Dominique Gagnon, Louise Belzile, Yahya Mosbah, Mylaine Breton
Context: Two reforms (2014, 2015) characterised by the merger of public health care establishments profoundly shaped the current organisation of Quebec's healthcare system. In 2015, 22 megastructures called Integrated Health and Social Services Centres/Integrated University Health and Social Services Centres (IHSSC/IUHSSC), were created and mandated to organise care delivery to their local populations. Objective: To describe the service configuration of the 2015 healthcare system reforms, emphasising on how it shaped the organisation of primary health care (PHC) in Quebec...
May 2018: London Journal of Primary Care
https://www.readbyqxmd.com/read/30042618/molecular-insights-into-genetic-diversity-and-population-dynamics-of-five-medicinal-eulophia-species-a-threatened-orchid-taxa-of-africa
#16
Paromik Bhattacharyya, Johannes van Staden
Genetic diversity existing amongst five Eulophia orchid species were assessed using start codon targeted polymorphism (SCoT) and inter-retrotransposon amplified polymorphism (IRAP) markers. A total of 12 SCoT and 5 IRAP markers revealed an average of 63% genetic variability [SCoT = 63.87; IRAP = 64.95%] amongst the five Eulophia species investigated. The genetic similarities were assessed using both UPGMA and Bayesian approaches which indicated identical clustering patterns at a genetic similarity level of 50%...
July 2018: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/30039466/-big-data-and-deep-learning-in-preventive-and-rehabilitation-medicine
#17
REVIEW
M Jäger, C Mayer, H Hefter, M Siebler, A Kecskeméthy
The digitalization in medicine has led to almost universal availability of information to different healthcare professionals and accelerated clinical pathways. Fast-track concepts and short hospital stays require intelligent and practicable systems in preventive and rehabilitation medicine. This includes optimization of movement analysis by innovative tools such as detectors sensing skin movements, portable feedback systems for monitoring, robot-assisted devices, and prevention programs based on reliable data...
July 23, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/30037304/estimating-mean-local-posterior-predictive-benefit-for-biomarker-guided-treatment-strategies
#18
Meilin Huang, Brian P Hobbs
Precision medicine has emerged from the awareness that many human diseases are intrinsically heterogeneous with respect to their pathogenesis and composition among patients as well as dynamic over the course therapy. Its successful application relies on our understanding of distinct molecular profiles and their biomarkers which can be used as targets to devise treatment strategies that exploit current understanding of the biological mechanisms of the disease. Precision medicine present challenges to traditional paradigms of clinical translational, however, for which estimates of population-averaged effects from large randomized trials are used as the basis for demonstrating improvements comparative effectiveness...
January 1, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30032987/can-positron-emission-tomography-support-the-characterization-of-immune-mediated-inner-ear-disease
#19
J Mucientes Rasilla, L Ortiz Evan, I Villarreal, J R García-Berrocal
INTRODUCTION: To evaluate the utility of 18 F-FDG PET/TC as an imaging tool for the characterization of immune-mediated inner ear disease (IMIED), providing measurements of the inner ear region activity as well as detecting possible involvement of other organs. MATERIAL AND METHODS: The study included 28 patients with IMIED and 4 sex-matched and age-matched control subjects with no history of ear disease. Eighteen patients were considered to be suffering from primary IMIED and 10 patients from secondary...
July 19, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/30023534/the-chemical-sciences-and-health-strengthening-synergies-at-a-vital-interface
#20
EDITORIAL
Stephen A Matlin, Goverdhan Mehta, Alain Krief, Henning Hopf
The indispensable contributions to health made by the chemical sciences have become increasingly constrained by three systemic factors. These involve fragmentations: in the way that the chemicals sciences are structured, practiced, and inter-related to aspects of health; in the combination of public and private efforts delivering medicinal products; and in the regulatory systems which oversee health-related issues across health, food, and the environment. Interlinked systemic reforms are advocated, involving (1) recontextualization of the chemistry/health interface through creating a recognized field of "the chemical sciences and health"; (2) determined and comprehensive efforts, by countries wishing to retain or strengthen their pharmaceutical development capacities, to reinforce their education, research, and innovation eco-systems; and (3) adoption of an integrated approach to the regulation of pharmaceuticals, food, and the environment...
October 31, 2017: ACS Omega
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