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Interal Medicine

Anneke A Boerlage, Joost van Rosmalen, Juanita M Cheuk-Alam-Balrak, Jeannette A Goudzwaard, Dick Tibboel, Monique van Dijk
BACKGROUND: The Rotterdam Elderly Pain Observation Scale (REPOS) has been proven useful to assess pain in non-communicative and cognitively impaired nursing home residents. We evaluated whether the REPOS is also reliable and valid for pain assessment in the hospital setting. METHODS: In this prospective multicenter observational study, surgical patients were observed perioperatively at bedside and internal medicine patients were filmed during a possible painful moment and in rest...
December 16, 2018: Pain Practice: the Official Journal of World Institute of Pain
Aunaly Palmer, Lisa A Taitsman, May J Reed, Bala G Nair, Itay Bentov
Hip fractures result in significant morbidity and mortality in elders. Indicators of frailty are associated with poor outcomes. Commonly used frailty tools rely on motor skills that cannot be performed by this population. We determined the association between the Charlson Comorbidity Score (CCS), intraoperative hypotension (IOH), and a geriatric medicine consult index (GCI) with short-term mortality in hip fracture patients. A retrospective cohort study was conducted at a single institution over a 2-year period...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
Paul Georg Werthmann, Pia Inter, Thilo Welsch, Anne-Kathrin Sturm, Robert Grützmann, Markus Debus, Martin-Günther Sterner, Gunver Sophia Kienle
RATIONALE: Metastatic pancreatic cancer has a dismal prognosis. Many patients seek integrative care as an add-on to their conventional cancer treatment. Viscum album extracts (VAE)-widely used as an adjunct to cancer treatment-have cytotoxic, apoptogenic, and immune stimulatory properties. A statistically significant survival benefit has been demonstrated for VAE in advanced pancreatic cancer. PATIENT CONCERNS AND DIAGNOSIS: A 28-year old patient presented with painless jaundice and was subsequently diagnosed as pancreatic adenocarcinoma with liver metastases...
December 2018: Medicine (Baltimore)
Rebecca Langhorn, Jacob D Yrfelt, Claus S Stjernegaard, Liselotte B Christiansen, Lisbeth H Olsen, Lise N Nielsen
BACKGROUND: Cardiac troponins are gold-standard biomarkers of myocardial injury. There is a need for validation of assays with higher availability and lower costs in veterinary medicine. OBJECTIVES: The primary aim of the present study was to perform an analytical validation of the IMMULITE 2000 TnI assay for use in dogs and cats. A secondary aim was to evaluate its agreement with the previously validated and sensitive Siemens ADVIA Centaur TnI-Ultra assay. METHODS: Intra- and inter-assay variation, detection limits, the linearity under dilution, and a sample addition study (modified spike-and-recovery analysis) were investigated to assess analytical performance in 15 canine and 15 feline serum samples...
December 11, 2018: Veterinary Clinical Pathology
Cemal Ozemek, Ross Arena
Physical inactivity is strongly associated with an unfavorable health profile, increasing an individual's risk for developing cardiovascular disease. Initiating a regular exercise routine contributes to improvements in cardiorespiratory fitness, body composition, resting blood pressure, blood glucose, and circulating lipoproteins. However, the extent to which positive changes occur come with significant inter-individual variability within intervention groups; non-responders and responders have been commonly identified across populations, highlighting that not all exercise regimens are universally effective in all individuals and should therefore not be treated as a "one-size fits all" prescription...
December 7, 2018: Progress in Cardiovascular Diseases
Seitaro Nomura
Cardiomyopathy, a leading cause of death worldwide, is etiologically and phenotypically heterogeneous and is caused by a combination of genetic and non-genetic factors. Major genomic determinants of dilated cardiomyopathy (DCM) are titin truncating mutations and lamin A/C mutations. Patients with these two genotypes show critically different phenotypes, including penetrance, coexistence with a conduction system abnormality, cardiac prognosis, and treatment response. The transcriptomic and epigenomic characteristics of DCM include activation of the DNA damage response, metabolic reprogramming, and dedifferentiation...
December 4, 2018: Journal of Cardiology
Cindy J Chang, Timothy Weston, Jessica D Higgs, Monica Ohkubo, Amy Sauls, Fred Tedeschi, Marianne White, Craig C Young
No abstract text is available yet for this article.
December 7, 2018: Journal of Athletic Training
Teresa Leonardo Alves, Elita Poplavska, Signe Mezinska, Ieva Salmane-Kulikovska, Liga Andersone, Aukje K Mantel-Teeuwisse, Barbara Mintzes
BACKGROUND: European legislation prohibits direct-to-consumer advertising of prescription medicines, but allows drug manufacturers to provide information to the public on health and diseases. Our aim was to measure the frequency of disease awareness campaigns in Latvian media and assess their compliance with international and European standards. METHODS: Materials on health/disease and treatments were collected between April and September 2015 from 12 newspapers and magazines and six online portals...
November 28, 2018: BMC Public Health
Shuai Sun, Shunjun Xu, Yijuan Xu, Longgang Guo, Hailing Liu, Liu Yang, Zhengtao Wang, Li Yang
In this paper, a novel high throughput screening method for antioxidants was described. The screening process was completed on a 5 cm × 5 cm silica gel 60 plate. Luminol was used as the fluorogenic substrate while hydrogen peroxide employed to excite the chemiluminescence. A dark spot was observed due to quenching effect of antioxidant. A linear model of the integral area of the spot as a function of analyte amount was fit by using vitamin C as positive control. Excellent linearity (R2  = 0.9978) was obtained in the range of 2...
January 10, 2019: Analytica Chimica Acta
Abbas Rattani, Gabriel Felix, Martin L Campbell
There is a profound absence of Black men in medicine. Addressing this issue requires a concerted and holistic effort that includes learning from the current generation of medical students. This article summarizes three medical student perspectives presented as posters at the National Academies of Science, Engineering, and Medicine inaugural workshop on the growing absence of Black men in medicine. These posters present perspectives from men of color each from one of the three historically Black medical colleges in the country...
November 26, 2018: Journal of Racial and Ethnic Health Disparities
M Ortiz, M Teut, E Ben-Arye, A Reshef, M Kaffman, Z Arnon, B Stöckigt, V Bähr, L Meoded-Danon, B Brinkhaus, E Schiff
INTRODUCTION: Communication is an essential component of patient care, and although medical schools provide training on this topic, patients and physicians alike express the need to improve their communication skills. An international medical student collaboration explored whether complementary medicine (CM) has the ability to further enhance patient-doctor communication. METHODS: Twenty-two medical students, nine mentors and two public representatives from Israel and Germany participated in this 18-month international group project...
December 2018: Complementary Therapies in Medicine
Chiara Molinari, Giorgia Marisi, Alessandro Passardi, Laura Matteucci, Giulia De Maio, Paola Ulivi
High inter-patient variability and high spatial heterogeneity are features of colorectal cancer (CRC). This may influence the molecular characterization of tumor tissue, now mandatory for patients with metastatic CRC who are candidates for treatment with an anti-EGFR mAb, as false-negative results can occur, leading to non optimal therapy. Moreover, temporal molecular heterogeneity during treatment is known to influence the response to therapy and prognosis. We present a literature overview of advances made in characterizing molecular heterogeneity in CRC, underlining that the analysis of liquid biopsy could represent an efficient non-invasive tool to overcome the problem...
November 23, 2018: International Journal of Molecular Sciences
Andreas Meier, Harini Veeraraghavan, Stephanie Nougaret, Yulia Lakhman, Ramon Sosa, Robert A Soslow, Elizabeth J Sutton, Hedvig Hricak, Evis Sala, Hebert A Vargas
PURPOSE: To assess the associations between inter-site texture heterogeneity parameters derived from computed tomography (CT), survival, and BRCA mutation status in women with high-grade serous ovarian cancer (HGSOC). MATERIALS AND METHODS: Retrospective study of 88 HGSOC patients undergoing CT and BRCA mutation status testing prior to primary cytoreductive surgery. Associations between texture metrics-namely inter-site cluster variance (SCV), inter-site cluster prominence (SCP), inter-site cluster entropy (SE)-and overall survival (OS), progression-free survival (PFS) as well as BRCA mutation status were assessed...
November 24, 2018: Abdominal Radiology
A P Lopes, M A Mineiro, F Costa, J Gomes, C Santos, C Antunes, D Maia, R Melo, M Canotilho, E Magalhães, I Vicente, C Valente, B G Gonçalves, B Conde, C Guimarães, C Sousa, J Amado, M E Brandão, M Sucena, M J Oliveira, S Seixas, V Teixeira, L Telo
Alpha-1-antitrypsin deficiency (AATD) is a genetic autosomal codominant disorder caused by mutations in SERPINA1 gene. It is one of the most prevalent genetic disorders, although it remains underdiagnosed. Whereas at international level there are several areas of consensus on this disorder, in Portugal, inter-hospital heterogeneity in clinical practice and resources available have been adding difficulties in reaching a diagnosis and in making therapeutic decisions in this group of patients. This raised a need to draft a document expressing a national consensus for AATD...
December 2018: Pulmonology
Arima Mishra, Devaki Nambiar
BACKGROUND: India has recently renewed emphasis on non-allopathic systems of medicine as a means to address the health needs of its populace. Earlier in 2002, its national health policy had sought to 'revitalize' community-based health knowledge and practices - jointly christened 'local health traditions'. Yet policy texts remain silent on the actual means by which 'revitalization of local health traditions' should take place. Our research sought to understand the policy lessons of and for revitalization of local health traditions in the three Southern Indian states through an ethnographic inquiry in 2014-2016...
November 23, 2018: International Journal for Equity in Health
S Buczinski, S Ferraro, J M Vandeweerd
OBJECTIVE: Evidence-based medicine (EBM) is used in various areas including veterinary medicine. The assessment of the quality of systematic review and meta-analyses (SR-MA) despite their importance in the EBM process is uncommonly performed in veterinary medicine due to the absence of specific dedicated tools. The main objective of this observational study was to examine the extent and nature of SR-MA that can be available online to an equine or bovine veterinarian. Secondary objectives included: (1) to determine if A MeaSurement Tool to Assess systematic Reviews (AMSTAR) tool can be used for equine and bovine SR-MA methodological assessment and if it has a satisfactory interrater reliability in a subsample of these SR-MA and (2) to appraise the completeness of abstract reporting of this sample...
December 1, 2018: Preventive Veterinary Medicine
Thomas Hengl, Jörn Herfert, Alexander Soliman, Kim Schlinzig, Ralph M Trüeb, Harry F Abts
BACKGROUND: Ultraviolet radiation (UVR) is known to be harmful to normal human epidermal keratinocytes (NHEKs) of the epidermal skin layer, as well as to hair-follicle-associated keratinocytes. An oral formulation containing l-cystine, thiamin, calcium d-pantothenate, medicinal yeast, keratin and p-aminobenzoic acid (Panto[vi]gar®) has demonstrated clinical efficacy for the treatment of diffuse telogen effluvium; however, its mode of action at the cellular level, and in particular whether protective mechanisms are involved, has yet to be elucidated...
September 17, 2018: Journal of Photochemistry and Photobiology. B, Biology
Piao Zhang, Meng-Ke Yang, Jun Zhu, Xiao-Jin Li, Ru Feng, Rong Xu, Jun Chen
To intuitively understand the phenotypic diversity of intra-population and inter-population of the medicinal Cistanche Herba distributed in Xinjiang province, three species of Cistanche Herba were selected for the first time to be conducted to phenotypic observation and measurement from the morphological perspective, aiming to fill the gap in the morphological research concerning Cistanche Herba, and discuss about the relationship between the phenotypic variation and the host plants together with the geographical conditions, thus better understanding the speciation and evolutionary mechanism of Cistanche Herba and providing some scientific basis for the resource protection and germplasm breeding of Cistanche Herba...
October 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Brian K Chen, Y Tony Yang, Charles L Bennett
Biologics and biosimilars are medicines made from living cells that treat common and serious diseases such as cancer, diabetes, rheumatoid arthritis, and other inflammatory diseases. They are highly targeted, efficacious, and represent an increasingly important part of physicians' armamentaria in the combat against these medical conditions. Yet they are extremely expensive, costing on average $10,000-$30,000 per year and exceed $500,000 for the most expensive biologics. The advent of biosimilar drugs, or high similar copies of biologics, was supposed to help reduce costs, but thus far the cost of treatment with biologics or biosimilars has not fallen sharply in the USA...
November 16, 2018: Drugs
Julie J Kim, Edmund S H Kwok, Olivia G Cook, Lisa A Calder
Introduction: Highly frequent users (HFU) of the emergency department (ED) are a poorly defined population. This study describes patient and visit characteristics for Canadian ED HFU and patient subgroups with mental illness, substance misuse, or ≥ 30 yearly ED visits. Methods: We reviewed health records from a random selection of adult patients whose visit frequency comprised the 99th percentile of yearly ED visits to The Ottawa Hospital. We excluded scheduled repeat ED assessments...
November 2018: Western Journal of Emergency Medicine
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