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https://www.readbyqxmd.com/read/30121845/course-of-colonization-by-multidrug-resistant-organisms-after-allogeneic-hematopoietic-cell-transplantation
#1
D Heidenreich, S Kreil, M Jawhar, N Müller, F Nolte, K-P Becker, T Miethke, W-K Hofmann, Stefan A Klein
Multidrug-resistant organisms (MDRO) have been developing as an emerging problem in allogeneic hematopoietic cell transplantation (HCT). Since no data are available on the course of MDRO colonization after HCT, we investigated in this retrospective, single-center study, persistence and clearance of MDRO after HCT. From June 2010 to December 2015, 121 consecutive HCT patients were included. Patients received a MDRO screening before conditioning as well as surveillance cultures after HCT. In MDRO-colonized patients, surveillance specimens were taken until MDRO were no longer detectable...
August 18, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/30121683/the-prevalence-and-the-risk-of-falls-among-institutionalised-elderly-in-penang-malaysia
#2
S H Kioh, A Rashid
INTRODUCTION AND OBJECTIVES: Over the years, falls has been increasingly the most common public health issue worldwide that affects all age groups. However, the risk is nine times higher in older persons especially among those residing in nursing homes. The objective of this study is to determine the prevalence and the risk of falls and their associated factors among elderly living in nursing homes in Penang, Malaysia. METHODOLOGY: Data were obtained from a cross-sectional survey in ten different nursing homes in the state of Penang, Malaysia...
August 2018: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/30121478/the-breastfeeding-self-efficacy-scale-short-form-psychometric-characteristics-in-portuguese-pregnant-women
#3
Sónia Brandão, Denisa Mendonça, Cláudia Castro Dias, Tiago Miguel Pinto, Cindy-Lee Dennis, Bárbara Figueiredo
BACKGROUND: The Breastfeeding Self-Efficacy Scale-Short Form is a reliable instrument to measure mother's confidence in her ability to breastfeed. The Breastfeeding Self-Efficacy Scale-Short Form has traditionally been used postnatally, but evidence suggests that it can be used antenatally to identify mothers at-risk of requiring additional support to improve breastfeeding outcomes. OBJECTIVE: The aim of this study was to examine the psychometric characteristics of an antenatal version of the Breastfeeding Self-Efficacy Scale-Short Form, among pregnant Portuguese women...
July 29, 2018: Midwifery
https://www.readbyqxmd.com/read/30121375/depression-and-healthcare-utilization-at-end-of-life-among-older-adults-with-advanced-non-small-cell-lung-cancer
#4
Cara McDermott, Aasthaa Bansal, Scott D Ramsey, Gary H Lyman, Sean D Sullivan
CONTEXT: Limited data exist regarding how depression diagnosed at different times relative to a cancer diagnosis may affect healthcare utilization at end of life (EOL). OBJECTIVES: To assess the relationship between depression and health care utilization at EOL among older adults (ages >=67) diagnosed with advanced non-small cell lung cancer (NSCLC) from 2009-2011. METHODS: Using the SEER-Medicare database, we fit multivariable logistic regression models to explore the association of depression with duration of hospice stay plus high-intensity care, e...
August 16, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/30121360/production-of-di-2-ethylhexyl-phthalate-by-bacillus-subtilis-ad35-isolation-purification-characterization-and-biological-activities
#5
Walid A Lotfy, Sahar W Mostafa, Amr A Adel, Khaled M Ghanem
The emergence of extensive antibiotics resistant bacteria increased the demands for finding out new sources of antimicrobial agents. Marine niches were reported to be rich in many competent producers of significant bioactive compounds. On the course of screening program for new antimicrobials, a Bacillus strain was isolated from Alexandria sea shores, Egypt. According to the morphological, cultural and biochemical characteristics, 16S rRNA sequence analysis and matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS), the strain was identified as B...
August 16, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/30121009/characterizing-microsatellite-instability-and-chromosome-instability-in-interval-colorectal-cancers
#6
Amy L Cisyk, Zoann Nugent, Robert H Wightman, Harminder Singh, Kirk J McManus
There are a substantial portion of colorectal cancers (CRCs), termed interval CRCs (I-CRCs), that are diagnosed shortly after a negative colonoscopy (i.e., no detectable polyps or CRC) and before recommended follow-up screening. The underlying cause(s) accounting for I-CRCs remain poorly understood, but may involve aberrant biology that drives genome instability. Genetic defects inducing genome instability are pathogenic events that lead to the development and progression of traditional sporadic (Sp-) CRCs...
August 15, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/30120955/quantitative-assessment-of-mucosal-architecture-using-computer-based-analysis-of-confocal-laser-endomicroscopy-in-inflammatory-bowel-diseases
#7
L Quénéhervé, G David, A Bourreille, J B Hardouin, G Rahmi, N Neunlist, J Brégeon, E Coron
BACKGROUND AND AIMS: Confocal endomicroscopy (CLE) might discriminate mucosal lesions between Crohn's disease (CD) and ulcerative colitis (UC). However, the analysis of CLE images requires time-consuming methods, a long training time and potential impediments, such as significant interobserver variability. Therefore, we developed a computer-based method to analyze mucosal architecture from CLE images and discriminate between healthy subjects and patients with inflammatory bowel disease (IBD) as well as between UC and CD patients...
August 15, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/30120852/characterization-of-mutation-spectrum-and-identification-of-novel-mutations-in-atp7b-gene-from-a-cohort-of-wilson-disease-patients-functional-and-therapeutic-implications
#8
Niti Kumari, Aman Kumar, Babu Ram Thapa, Manish Modi, Arnab Pal, Rajendra Prasad
Wilson disease (WD), a copper metabolism disorder, occurs due to the presence of mutations in the gene encoding ATP7B, a protein that primarily facilitates hepatic copper excretion. A better understanding of spectrum and functional significance of ATP7B variants is critical to formulating targeted and personalized therapies. Henceforth, we screened and sequenced 21 exons of ATP7B gene from 50 WD patients and 60 healthy subjects. We identified 28 variants comprising, seven novels in 20% alleles, while eight variations affecting 23% alleles were first time reported in Indian cohort...
August 18, 2018: Human Mutation
https://www.readbyqxmd.com/read/30120709/lncrna-pvt1-facilitates-tumorigenesis-and-progression-of-glioma-via-regulation-of-mir-128-3p-grem1-axis-and-bmp-signaling-pathway
#9
Chao Fu, Dongyuan Li, Xiaonan Zhang, Naijie Liu, Guonan Chi, Xingyi Jin
The current research was aimed at probing into the role of long noncoding RNA (lncRNA) PVT1 in the pathogenesis of glioma and the regulatory mechanism of PVT1/miR-128-3p/GREM1 network in glioma via regulation of the bone morphogenetic protein (BMP) signaling pathway. Microarray analysis was used for preliminary screening for candidate lncRNAs and mRNAs in glioma tissues. Real-time quantitative polymerase chain reaction, Western blot, MTT assay, flow cytometry, migration and invasion assays, and xenograft tumor model were utilized to examine the influence of the lncRNA PVT1/miR-128-3p/GREM1 network on the biological functions of glioma cells...
August 17, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/30120634/mitochondrial-dna-copy-number-in-peripheral-blood-a-potential-non-invasive-biomarker-for-female-subfertility
#10
Andrea Busnelli, Debora Lattuada, Raffaella Rossetti, Alessio Paffoni, Luca Persani, Luigi Fedele, Edgardo Somigliana
PURPOSE: Low mitochondrial DNA (mtDNA) content in oocytes and in cumulus cells is an indicator of poor oocyte quality. Moreover, initial evidence showed a correlation between mtDNA content in cumulus cells and mtDNA copy number in peripheral blood cells. On these bases, we deemed of interest investigating the correlation between mtDNA copy number in peripheral blood and natural fecundity. METHODS: This is a nested case-control study drawn from a prospective cohort of pregnant women referred for routine first trimester screening for aneuploidies (from 11 + 0 to 12 + 6 weeks of gestation) between January 2012 and March 2013 at the "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico" of Milan, Italy...
August 17, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/30120260/patterns-of-early-primary-school-based-literacy-interventions-among-pacific-children-from-a-nationwide-health-screening-programme-of-4-year-olds
#11
Philip J Schluter, Jesse Kokaua, El-Shadan Tautolo, Rosalina Richards, Tufulasi Taleni, Hyun M Kim, Richard Audas, Brigid McNeill, Barry Taylor, Gail Gillon
Literacy success is critical to unlocking a child's potential and enhancing their future wellbeing. Thus, the early identification and redressing of literacy needs is vital. Pacific children have, on average, the lowest literacy achievement levels in New Zealand. However, this population is very diverse. This study sought to determine whether the current national health screening programme of pre-school children could be used as an early detection tool of Pacific children with the greatest literacy needs. Time-to-event analyses of literacy intervention data for Pacific children born in years 2005-2011 were employed...
August 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30119893/anti-survivin-single-domain-antibodies-derived-from-an-artificial-library-including-three-synthetic-random-regions-by-in-vitro-selection-using-cdna-display
#12
Takeru Suzuki, Yuki Mochizuki, Shinnosuke Kimura, Yoko Akazawa-Ogawa, Yoshihisa Hagihara, Naoto Nemoto
Single-domain antibodies (variable domain of the heavy chain of a heavy chain antibody; VHH) are promising reagents for therapeutics and diagnostics because of their stability, cost-effective production and material workability as a small antibody. Currently, general acquisition of a VHH using immunization of camelids is inconvenient from the standpoint of animal protection, cost and the process is time-consuming. Thus, a straightforward and efficient method for screening VHHs against a target molecule is required...
August 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30119761/amenorrhoea-in-adolescent-female-athletes
#13
REVIEW
Kathryn E Ackerman, Madhusmita Misra
Female athletes often experience amenorrhoea at various times during training, but this should not be considered normal. Low energy availability is a common cause of menstrual dysfunction, and amenorrhoea can serve as a warning sign of some of the health and performance consequences associated with inadequate energy, including poor bone accrual and low bone mineral density. Adolescence is an important time for bone accrual, growth, and development, making delayed menarche and secondary amenorrhoea particularly concerning in young athletes...
September 2018: Lancet Child & Adolescent Health
https://www.readbyqxmd.com/read/30119640/the-long-term-outcomes-and-health-related-quality-of-life-of-patients-following-blunt-thoracic-injury-a-narrative-literature-review
#14
REVIEW
Edward Baker, Andreas Xyrichis, Christine Norton, Philip Hopkins, Geraldine Lee
BACKGROUND: Major Trauma remains a leading cause of mortality and morbidity worldwide. Blunt Thoracic Injury (BTI) accounts for > 15% of United Kingdom (UK) trauma admissions and is consistently associated with respiratory related complications that include pneumonia and respiratory failure. Despite this, it is unclear in current clinical practice how BTI impacts on the recovering trauma patients after discharge from hospital. This study aimed to investigate the state of knowledge on the impact of BTI on the long-term outcomes and health-related quality of life (HRQoL)...
August 17, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/30119087/integrated-rehabilitation-for-breast-cancer-survivors
#15
Andrea L Cheville, Sarah A McLaughlin, Tufia Haddad, Kathleen D Lyons, Robin Newman, Kathryn J Ruddy
The physical and psychological side effects of breast cancer therapies can have substantial impact on survivors' physical and social functioning. Roughly half of the more than 3 million Americans alive with a history of breast cancer report adverse, function-degrading sequelae related to their oncologic treatments. Care delivery models for the timely delivery of rehabilitation services have been proposed yet limitedly vetted or implemented. These include the prospective surveillance model, procedure-linked referrals, survivorship care plans and risk stratification...
August 16, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/30119086/is-it-time-to-give-athletes-a-voice-in-the-dissemination-strategies-of-concussion-related-information-exploratory-examination-of-2444-adolescent-athletes
#16
Mark Beakey, Brian Keenan, Stephen Tiernan, Kieran Collins
OBJECTIVE: The objective of the research was to screen male and female adolescent athletes on their concussion educational histories and preferred future methods of education in terms of educational messenger, modality, and concussion-related areas of interest. DESIGN: Cross-sectional survey. SETTING: Examination setting within the classroom. PARTICIPANTS: Adolescent male (n = 1854) and female (n = 590) athletes aged 12 to 18 years...
August 15, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/30118943/cognitive-reappraisal-moderates-the-relationship-between-ptsd-symptoms-and-alcohol-use-over-time-in-post-9-11-u-s-military-veterans
#17
Darrin M Aase, Stephanie M Gorka, Justin E Greenstein, Eric Proescher, Natania A Crane, Llashe-Kaye Everett, Ikram Hassan, Amanda Osborn, Christopher Schroth, Amy Kennedy-Krage, K Luan Phan
BACKGROUND: Rates of comorbid alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) are increasing among post-9/11 veterans, and emotion regulation problems have been identified as a feature of both disorders. However, no studies to date have explored how individual differences in emotion regulation may moderate the relationship between PTSD symptoms and alcohol use. We evaluated how two core emotion regulation strategies - one adaptive (i.e., cognitive reappraisal) and one maladaptive (i...
August 7, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/30118800/peptides-as-adjuvants-for-ampicillin-and-oxacillin-against-methicillin-resistant-staphylococcus-aureus-mrsa
#18
Praveen Rishi, Shania Vij, Indresh Kumar Maurya, Ujjwal Jit Kaur, Sanjay Bharati, Rupinder Tewari
Fast emerging antibiotic resistance in pathogens requires special attention for strengthening the reservoir of antimicrobial compounds. In view of this, several peptides with known antimicrobial activities have been reported to enhance the efficacy of antibiotics against multidrug resistant (MDR) pathogens. In the present study, potential of peptides having distinct mechanism of action, if any, was evaluated to improve the efficacy of conventional antibiotics against methicillin-resistant S. aureus (MRSA). After primary screening of six peptides, two peptides namely T3 and T4 showing very high minimum inhibitory concentrations (MICs) were selected to assess their role in altering the MICs of antibiotics to which the pathogen was resistant...
August 14, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/30118779/development-of-an-extraction-method-for-anabolic-androgenic-steroids-in-dietary-supplements-and-analysis-by-gas-chromatography-mass-spectrometry-application-for-doping-control
#19
Hajer Dahmani, Kaouthar Louati, Adel Hajri, Senda Bahri, Fathi Safta
Several studies have highlighted that nutritional supplements may contain undeclared anabolic steroids that are banned by the International Olympic Committee/World Anti-Doping Agency. Any kind of abuse with these drugs is extremely dangerous because of their side effects. Thus, the control of food additives in order to protect the best consumer health and to limit fraudulent practices in the field of sports is essential. This paper describes a simple and effective qualitative gas chromatography-mass spectrometry (GC-MS) method to detect anabolic androgenic steroids (AAS): androsterone, nandrolene, dehydroepiandrosterone, 5ɑ-androstane-3β, 17β-diol, dihydrotestosterone, testosterone, methenolone acetate, methandienone, boldenone and fluoxymesterone, in food supplements...
August 14, 2018: Steroids
https://www.readbyqxmd.com/read/30118769/structure-based-identification-and-biological-evaluation-of-novel-and-potent-inhibitors-of-pcaf-catalytic-domain
#20
Venkatesan Suryanarayanan, Tamilselvam Rajavel, Kasi Pandima Devi, Sanjeev Kumar Singh
p300/CBP Associated Factor (PCAF), a GNAT family member protein, represent a valid target for therapeutic interventions since its dysfunction has implicated in variety of diseases like cancer, diabetes, inflammatory diseases, etc. Despite its potential for therapeutics, only a small number of PCAF inhibitors were reported. Hence, in this study, the catalytic domain of PCAF was explored to screen novel, potent and cell permeable inhibitor from three small molecule databases like Life Chemical, Maybridge and Chembridge by using Structure Based Virtual Screening (SBVS) method...
August 10, 2018: International Journal of Biological Macromolecules
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