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Brandon Barnds, William Tucker, Brandon Morris, Armin Tarakemeh, John Paul Schroeppel, Scott Mullen, Bryan G Vopat
BACKGROUND: Controversy exists regarding optimal primary management of Lisfranc injuries. Whether open reduction internal fixation (ORIF) or primary arthrodesis is superior remains unknown. METHODS: A national insurance database of approximately 23.5 million orthopedic patients was retrospectively queried for subjects who were diagnosed with a Lisfranc injury from 2007 to 2016 based on international classification of diseases (ICD) codes (PearlDiver, Colorado Springs, CO)...
October 3, 2018: Injury
Prabhu P Gounder, Anders Koch, Ginger Provo, Astrid Lovlie, Josefine Lundberg Ederth, Maria Axelsson, Chris P Archibald, Brendan Hanley, Angie Mullen, Myrna Matheson, David Allison, Henrik Trykker, Thomas W Hennessy, Markku Kuusi, Vladimir Chulanov, Brian J McMahon
We summarised available hepatitis C virus (HCV) surveillance data for 2012-14 from Arctic/sub-Arctic countries/regions. We sent a HCV data collection template by email to public health authorities in all jurisdictions. Population statistics obtained from census sources for each country were used to estimate rates of reported acute and chronic/undifferentiated HCV cases. Seven countries with Arctic regions (Canada, Denmark, Finland, Greenland, Norway, Sweden and the United States, represented by the state of Alaska), including three Canadian territories and one province, as well as 11 Russian subnational Arctic regions, completed the data collection template...
October 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
William B Tu, Yu-Jia Shiah, Corey Lourenco, Peter J Mullen, Dharmendra Dingar, Cornelia Redel, Aaliya Tamachi, Wail Ba-Alawi, Ahmed Aman, Rima Al-Awar, David W Cescon, Benjamin Haibe-Kains, Cheryl H Arrowsmith, Brian Raught, Paul C Boutros, Linda Z Penn
MYC is an oncogenic driver that regulates transcriptional activation and repression. Surprisingly, mechanisms by which MYC promotes malignant transformation remain unclear. We demonstrate that MYC interacts with the G9a H3K9-methyltransferase complex to control transcriptional repression. Inhibiting G9a hinders MYC chromatin binding at MYC-repressed genes and de-represses gene expression. By identifying the MYC box II region as essential for MYC-G9a interaction, a long-standing missing link between MYC transformation and gene repression is unveiled...
October 8, 2018: Cancer Cell
Mohammad A Obeid, Christine Dufès, Sukrut Somani, Alexander B Mullen, Rothwelle J Tate, Valerie A Ferro
RNA interference (RNAi) is an effective and naturally occurring post-transcriptional gene regulatory mechanism. This mechanism involves the degradation of a target messenger RNA (mRNA) through the introduction of short interfering RNA (siRNA) that is complementary to the target mRNA. The application of siRNA-based therapeutics is limited by the development of an effective delivery system, as naked siRNA is unstable and cannot penetrate the cell membrane. In this study, we investigated the use of cationic niosomes (CN) prepared by microfluidic mixing for siRNA delivery...
October 8, 2018: Journal of Liposome Research
Lori-Ann R Sacrey, Lonnie Zwaigenbaum, Susan Bryson, Jessica Brian, Isabel M Smith, Sarah Raza, Wendy Roberts, Peter Szatmari, Tracy Vaillancourt, Caroline Roncadin, Nancy Garon
BACKGROUND: Children with autism spectrum disorder (ASD) often experience impairments in adaptive behavior. METHODS: Developmental trajectories of adaptive behavior in ASD were examined in children from high-risk (siblings of children diagnosed with ASD, n = 403) and low-risk (no family history of ASD, n = 163) families. Children were assessed prospectively at 12, 18, 24, and 36 months of age using the Vineland Adaptive Behavior Scales and underwent a blind independent diagnostic assessment for ASD at 36 months of age...
October 8, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
Margaret C Fahey, G Wayne Talcott, Callie M Cox Bauer, Zoran Bursac, Leslie Gladney, Marion E Hare, Jean Harvey, Melissa Little, Deirdre McCullough, Ann S Hryshko-Mullen, Robert C Klesges, Mehmet Kocak, Teresa M Waters, Rebecca A Krukowski
No abstract text is available yet for this article.
October 4, 2018: Contemporary Clinical Trials
Jennifer L Kriss, Alison P Albert, Victoria M Carter, Angela J Jiles, Jennifer L Liang, Jennifer Mullen, Leslie Rodriguez, Penelope P Howards, Walter A Orenstein, Saad B Omer, Allison Fisher
Objectives The Advisory Committee on Immunization Practices (ACIP) and the American College of Obstetricians and Gynecologists (ACOG) recommend that pregnant women receive the Tdap vaccine during every pregnancy. The objectives of this paper are to evaluate disparities in Tdap vaccination among pregnant women in the U.S., and to assess whether race/ethnicity and other characteristics are associated with factors that inform pregnant women's decisions about Tdap vaccination. Methods We conducted a nationwide cross-sectional web-based survey of pregnant women in the U...
October 4, 2018: Maternal and Child Health Journal
Pamela J McCabe, Lynette G Stuart-Mullen, Christopher J McLeod, Thomas O Byrne, Monika M Schmidt, Megan E Branda, Joan M Griffin
Background: Higher levels of patient activation for self-managing health are associated with positive clinical and health care utilization outcomes. Identifying a patient's activation level can guide clinicians to tailor interventions to improve their health. Effective self-management of atrial fibrillation (AF) requires patient activation to participate in treatment decisions, prevent complications, and manage risk factors. Yet, little is known about activation in patients with AF. The purpose of this descriptive study was to identify patient activation levels and factors associated with activation in patients with AF...
2018: Patient Preference and Adherence
Pavlos Msaouel, Andrew L Hong, Elizabeth A Mullen, Michael B Atkins, Cheryl Lyn Walker, Chung-Han Lee, Marcus A Carden, Giannicola Genovese, W Marston Linehan, Priya Rao, Maria J Merino, Howard Grodman, Jeffrey S Dome, Conrad V Fernandez, James I Geller, Andrea B Apolo, Najat C Daw, H Courtney Hodges, Marva Moxey-Mims, Darmood Wei, Donald P Bottaro, Michael Staehler, Jose A Karam, W Kimryn Rathmell, Nizar M Tannir
Renal medullary carcinoma (RMC) is one of the most aggressive renal cell carcinomas. It predominantly afflicts young adults and adolescents with sickle cell trait and other sickle hemoglobinopathies, and is refractory to targeted and antiangiogenic therapies used in patients with clear-cell renal cell carcinoma. Platinum-based cytotoxic chemotherapy is the mainstay for RMC treatment. On the basis of recent advances in the diagnosis, management, and clinical trial development for RMC, a panel of experts met in October 2017 and developed updated consensus recommendations to inform clinicians, researchers, and patients...
September 12, 2018: Clinical Genitourinary Cancer
Steven L Flamm, Kevin D Mullen, Zeev Heimanson, Arun J Sanyal
Background: Cirrhosis-related complications are associated with poor prognosis. With our analyses, we examined the potential benefit of rifaximin in reducing the risk of developing cirrhosis-related complications. Methods: Adults with cirrhosis and hepatic encephalopathy (HE) in remission were randomly assigned to receive rifaximin 550 mg twice daily or placebo for 6 months with concomitant lactulose permitted. Post hoc analyses examined time to cirrhosis-related complications (HE, spontaneous bacterial peritonitis (SBP), variceal bleeding, acute kidney injury/hepatorenal syndrome)...
2018: Therapeutic Advances in Gastroenterology
Karen C Albright, Lei Huang, Justin Blackburn, George Howard, Michael Mullen, Vera Bittner, Paul Muntner, Virginia Howard
OBJECTIVE: To determine black-white differences in 1-year recurrent stroke and 30-day case fatality after a recurrent stroke in older US adults. METHODS: We conducted a retrospective cohort study using a 5% random sample of Medicare beneficiaries with fee-for-service health insurance coverage who were hospitalized for ischemic stroke between 1999 and 2013. Hazard ratios for recurrent ischemic stroke and risk ratios for 30-day case fatality comparing blacks to whites were calculated with adjustment for demographics, risk factors, and competing risk of death when appropriate...
October 3, 2018: Neurology
Rebecca A Krukowski, Marion E Hare, Gerald W Talcott, Leslie A Gladney, Karen C Johnson, Phyllis A Richey, Mehmet Kocak, Patrick L Keller, Ann Hryshko-Mullen, Robert C Klesges
OBJECTIVE: The purpose of this study, "Fit Blue," was to compare a translation of the Look AHEAD (Action for Heath in Diabetes) intensive lifestyle intervention with a self-paced version of the same intervention among active duty military personnel. METHODS: Active duty military personnel (N = 248; 49% male, 34% racial minority) with overweight or obesity were randomized to 12-month distance-based (i.e., phone and email) parallel programs, counselor-initiated (CI) condition or self-paced (SP) condition, from 2014 to 2016...
October 2018: Obesity
Jessica Bradshaw, Cheryl Klaiman, Scott Gillespie, Natalie Brane, Moira Lewis, Celine Saulnier
Achievement of early motor milestones in infancy affords new opportunities for social interaction and communication. Research has shown that both motor and social deficits are observed in infants who later develop autism spectrum disorder (ASD). The current study examined associations between motor and social-communication skills in 12-month-old infant siblings of children with ASD who are at heightened risk for developmental delays (N=86) and low-risk, typically developing infants (N=113). Infants were classified into one of three groups based on their walking ability: walkers (walks independently), standers (stands independently), or pre-walkers (does not yet stand or walk independently)...
September 2018: Infancy: the Official Journal of the International Society on Infant Studies
Jessica B Girault, Benjamin W Langworthy, Barbara D Goldman, Rebecca L Stephens, Emil Cornea, J Steven Reznick, Jason Fine, John H Gilmore
Intelligence is an important individual difference factor related to mental health, academic achievement, and life success, yet there is a lack of research into its early cognitive predictors. This study investigated the predictive value of infant developmental assessment scores for school-age intelligence in a large, heterogeneous sample of single- and twin-born subjects (N = 521). We found that Early Learning Composite (ELC) scores from the Mullen Scales of Early Learning have similar predictive power to that of other infant tests...
May 2018: Intelligence
Babita Panigrahi, Susan C Harvey, Lisa A Mullen, Eniola Falomo, Philip Di Carlo, Bonmyong Lee, Kelly S Myers
BACKGROUND: There are few data regarding the use and outcomes of Breast Imaging Reporting and Data System (BI-RADS) 3 assessment on breast magnetic resonance imaging (MRI). The aim of this study was to describe the imaging findings prompting a BI-RADS 3 assessment and to report their outcomes, including the timing of follow-up examinations. PATIENTS AND METHODS: We performed a retrospective study evaluating 199 breast lesions in 186 patients who were assigned a BI-RADS 3 assessment on breast MRI over a 5-year period...
August 31, 2018: Clinical Breast Cancer
Emily B Ambinder, Lisa A Mullen, Eniola Falomo, Kelly Myers, Jessica Hung, Bora Lee, Susan C Harvey
RATIONALE AND OBJECTIVES: Although the breast imaging reporting and data system (BI-RADS) lists specific criteria for designating a lesion as BI-RADS category 3 (probably benign), there are no target benchmarks for BI-RADS 3 usage rates. This study investigates the variability of BI-RADS 3 rates among a group of academic breast imagers, with the goal of defining more precise utilization. MATERIALS AND METHODS: We retrospectively reviewed all diagnostic mammograms performed between July 1, 2013 and August 8, 2017 at our academic institution...
September 27, 2018: Academic Radiology
T Gibbs, A D M Villa, E Sammut, S Jeyabraba, G Carr-White, T F Ismail, G Mullen, B Ganeshan, A Chiribiri
AIM: To determine whether heterogeneity of cardiac scar, as assessed by cardiovascular magnetic resonance (CMR) texture analysis, may provide insight into better risk stratification for patients with previous myocardial infarction (MI). MATERIALS AND METHODS: Patients with previous MI (n=76) were followed for a median of 371.5 days after late gadolinium enhancement (LGE) CMR. The primary endpoint was a composite of ventricular tachycardia, ventricular fibrillation, or unexplained syncope...
September 26, 2018: Clinical Radiology
C Verity Bennett, Sabine Maguire, Diane Nuttall, Daniel M Lindberg, Steven Moulton, Lalit Bajaj, Alison M Kemp, Stephen Mullen
INTRODUCTION: Appropriate first aid can reduce the morbidity of burns, however, there are considerable variations between international first aid recommendations. We aim to identify, and compare first aid practices in children who present to Emergency Departments (ED) with a burn. METHODS: A prospective cross-sectional study of 500 children (0-16 completed years) presenting with a burn to a paediatric ED in the UK (Cardiff) and the USA (Denver, Colorado), during 2015-2017...
September 25, 2018: Burns: Journal of the International Society for Burn Injuries
Cam Escoffery, E Lebow-Skelley, R Haardoerfer, E Boing, H Udelson, R Wood, M Hartman, M E Fernandez, P D Mullen
BACKGROUND: Adaptations of evidence-based interventions (EBIs) often occur. However, little is known about the reasons for adaptation, the adaptation process, and outcomes of adapted EBIs. To address this gap, we conducted a systematic review to answer the following questions: (1) What are the reasons for and common types of adaptations being made to EBIs in community settings as reported in the published literature? (2) What steps are described in making adaptations to EBIs? and (3) What outcomes are assessed in evaluations of adapted EBIs? METHODS: We conducted a systematic review of English language publications that described adaptations of public health EBIs...
September 26, 2018: Implementation Science: IS
Beth S Slomine, Faye S Silverstein, James R Christensen, Kent Page, Richard Holubkov, J Michael Dean, Frank W Moler
Importance: Little is known about neuropsychological outcomes of children who survived pediatric cardiac arrest (CA). Objective: To describe the neuropsychological outcomes of CA survivors enrolled in the Therapeutic Hypothermia After Pediatric Cardiac Arrest In-Hospital (THAPCA-IH) and Out-of-Hospital (THAPCA-OH) trials and compare the results with the primary outcome measure for these trials. Design, Setting, and Participants: Secondary analysis of 222 CA survivors aged 1 to 18 years who received chest compressions for 2 minutes or more, remained comatose and required mechanical ventilation after return of circulation, and were enrolled in targeted temperature-management trials from 41 pediatric intensive care units...
September 17, 2018: JAMA Neurology
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