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https://www.readbyqxmd.com/read/30119987/suspected-gonorrhea-and-chlamydia-incidence-and-utilization-of-empiric-antibiotics-in-a-health-system-emergency-department-setting
#1
Jenna Garlock, Leborah Lee, Michaelia Cucci, Lawrence A Frazee, Chanda Mullen
BACKGROUND: In the ED, patients are treated empirically for suspected gonorrhea and/or chlamydia (GC). Limited studies have evaluated the treatment of sexually transmitted diseases (STDs) in conjunction with predictor variables. This study will allow providers to better identify patients with potential GC to streamline antibiotic treatment. OBJECTIVES: The primary objective was to determine the incidence of positive assay in patients that underwent GC screening...
August 7, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/30115211/young-people-the-internet-and-mental-health
#2
D Chambers, K Cairns, L Ivancic
The original research by Mullen et al. in this issue is a welcome contribution to the increasingly important research area concerned with mental health and internet use. There is a persistent and growing tension between harmful online content and the potential to support vulnerable people online. Although current research has established both negative and positive influences of the internet on mental health, a policy framework to guide the development of online mental health resources is lacking. Based on 20 years of online service provision (in Australia originally and now in Ireland), ReachOut...
March 2018: Irish Journal of Psychological Medicine
https://www.readbyqxmd.com/read/30115201/internet-use-among-young-people-with-and-without-mental-health-difficulties
#3
G Mullen, C Dowling, G O'Reilly
OBJECTIVES: Research regarding adolescent internet use and mental health is sparse. However, awareness of a young person's internet use is becoming increasingly recognised as an important element of clinical assessment and intervention, and requires the development of an evidence base. The aim of the present study was to better understand the internet use of young people experiencing mental health difficulties and to contrast it with those who currently report no concerns. METHOD: In total, 299 young people aged 12-19 years, across a continuum of mental health difficulties, completed an online survey measuring internet use and related experiences...
March 2018: Irish Journal of Psychological Medicine
https://www.readbyqxmd.com/read/30105861/socioemotional-and-behavioral-problems-in-toddlers-with-language-delay
#4
Audrey Thurm, Stacy S Manwaring, Cecilia Cardozo Jimenez, Lauren Swineford, Cristan Farmer, Renee Gallo, Mika Maeda
Toddlers with language delay are at risk for persistent developmental and behavioral difficulties; however, the association between socioemotional/behavior problems and language in young children is not well understood. This study explored socioemotional/behavior problems in a unique sample of toddlers with language delays using a measure developed explicitly for this age group. Toddlers identified by 18 months with receptive and expressive language delay (LD; n = 30) or typical development (TD; n = 61) were evaluated at 18 and 24 months of age using the Infant-Toddler Social and Emotional Assessment (ITSEA) and the Mullen Scales of Early Learning...
August 14, 2018: Infant Mental Health Journal
https://www.readbyqxmd.com/read/30102564/improving-diagnostic-accuracy-in-clinically-ambiguous-paediatric-appendicitis-a-retrospective-review-of-ultrasound-and-pathology-findings-with-focus-on-the-non-visualised-appendix
#5
B S Kelly, S M Bollard, A Weir, C O'Brien, M Kerin, Dorinda Mullen, P McCarthy
OBJECTIVE: To compare preoperative ultrasound to histopathological results and retrospectively assess the diagnostic accuracy of ultrasound in paediatric appendicitis.' METHODS: 5 year review of all appendectomies performed in patients < 16 years old in a tertiary referral university hospital. 983 patients had an appendicectomy over the time period while 189 patients had a preoperative ultrasound. We retrospectively reviewed all of the preoperative imaging in conjunction with the reports for the 189 patients; our aim was to determine the sensitivity of preoperative ultrasound for the diagnosis of acute appendicitis...
August 13, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30101386/moderators-of-establishing-a-smoke-free-home-pooled-data-from-three-randomized-controlled-trials-of-a-brief-intervention
#6
Michelle C Kegler, Regine Haardörfer, Lucja T Bundy, Cam Escoffery, Rebecca S Williams, Mel Hovell, Matthew Kreuter, Patricia Dolan Mullen
Interventions to create smoke-free homes typically focus on parents, involve multiple counseling sessions and blend cessation and smoke-free home messages. Smoke-Free Homes: Some Things are Better Outside is a minimal intervention focused on smokers and nonsmokers who allow smoking in the home, and emphasizes creation of a smoke-free home over cessation. The purpose of this study is to conduct moderator analyses using pooled data from three randomized controlled trials of the intervention conducted in collaboration with 2-1-1 contact centers in Atlanta, North Carolina and Houston...
August 12, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/30092037/evaluating-the-impact-of-social-support-services-on-tuberculosis-treatment-default-in-ukraine
#7
Martha Priedeman Skiles, Siân L Curtis, Gustavo Angeles, Stephanie Mullen, Tatyana Senik
Ukraine is among the top 20 highest drug-resistant tuberculosis burden countries in the world. Driving the high drug-resistant tuberculosis rates is an unchecked treatment default rate. This evaluation measures the effect of social support provided to tuberculosis patients at risk of defaulting on treatment during outpatient treatment. Five tuberculosis patient cohorts, served in three oblasts from 2011 and 2012, were constructed from medical records to compare risk factors for default, receipt of social services, and treatment outcome...
2018: PloS One
https://www.readbyqxmd.com/read/30089919/engineering-of-robust-topological-quantum-phases-in-graphene-nanoribbons
#8
Oliver Gröning, Shiyong Wang, Xuelin Yao, Carlo A Pignedoli, Gabriela Borin Barin, Colin Daniels, Andrew Cupo, Vincent Meunier, Xinliang Feng, Akimitsu Narita, Klaus Müllen, Pascal Ruffieux, Roman Fasel
Boundaries between distinct topological phases of matter support robust, yet exotic quantum states such as spin-momentum locked transport channels or Majorana fermions1-3 . The idea of using such states in spintronic devices or as qubits in quantum information technology is a strong driver of current research in condensed matter physics4-6 . The topological properties of quantum states have helped to explain the conductivity of doped trans-polyacetylene in terms of dispersionless soliton states7-9 . In their seminal paper, Su, Schrieffer and Heeger (SSH) described these exotic quantum states using a one-dimensional tight-binding model10,11 ...
August 2018: Nature
https://www.readbyqxmd.com/read/30089448/a-qualitative-analysis-of-decision-making-among-women-with-sexual-violence-related-pregnancies-in-conflict-affected-eastern-democratic-republic-of-the-congo
#9
Jennifer Scott, Monica A Onyango, Gillian Burkhardt, Colleen Mullen, Shada Rouhani, Sadia Haider, Katherine Albutt, Ashley Greiner, Michael VanRooyen, Susan Bartels
BACKGROUND: Sexual violence is prevalent in conflict-affected settings and may result in sexual violence-related pregnancies (SVRPs). There are limited data on how women with SVRPs make decisions about pregnancy continuation or termination, especially in contexts with limited or restricted access to comprehensive reproductive health services. METHODS: A qualitative study was conducted in Bukavu, Democratic Republic of the Congo (DRC) as part of a larger mixed methods study in 2012...
August 8, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/30085890/assessment-and-improvement-strategies-for-a-breast-cancer-early-detection-program-in-rural-south-africa
#10
Megan Hadley, Lisa A Mullen, Lindsay Dickerson, Susan C Harvey
Purpose To assess and develop solutions for an ultrasound-based breast cancer early detection program in rural South Africa 1 year after implementation. Methods A WHO-endorsed RAD-AID Radiology Readiness Assessment was used to evaluate clinic resources. In addition, 5 weeks of observation identified resource deficiencies and reviewed existing documentation methods. On the basis of stakeholders' input and the BI-RADS, we developed new documentation systems. Training was followed by a survey that assessed feasibility and provider acceptance...
July 2018: Journal of Global Oncology
https://www.readbyqxmd.com/read/30084630/intrinsic-properties-of-single-graphene-nanoribbons-in-solution-synthetic-and-spectroscopic-studies
#11
Yinjuan Huang, Fugui Xu, Lucia Ganzer, Franco V A Camargo, Tetsuhiko Nagahara, Joan Teyssandier, Hans van Gorp, Kristoffer Basse, Lasse Arnt Straasø, Vaiva Nagyte, Cinzia Casiraghi, Michael Ryan Hansen, Steven De Feyter, Deyue Yan, Klaus Müllen, Xinliang Feng, Giulio Cerullo, Yiyong Mai
Structurally defined graphene nanoribbons (GNRs) are of interest due to their unique optical and electronic properties. However, strong π-π interactions typically cause distinct aggregation in liquid phase, thus hampering their solution processability. Here, we report a novel type of structurally defined graphene nanoribbons (GNRs) with uniform width of 1.7 nm and average length up to 58 nm. These GNRs are decorated with pending Diels-Alder cycloadducts of anthracenyl units and N-n-hexadecyl maleimide. The resultant bulky side groups on GNRs afford excellent dispersibility with concentrations of up to 5 mg/mL in many organic solvents such as tetrahydrofuran (THF), two orders of magnitude higher than the previously reported GNRs...
August 7, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/30080734/opioids-a-need-for-better-education-and-a-call-to-action-and-developing-safe-opioid-prescribing-practices-through-medical-student-education
#12
John T Mullen, Haytham M A Kaafarani, Roy Phitayakorn, Noelle N Saillant
No abstract text is available yet for this article.
August 3, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/30077789/a-phase-i-study-of-nilotinib-plus-radiation-in-high-risk-chordoma
#13
Gregory M Cote, Constance M Barysauskas, Thomas DeLaney, Joseph Schwab, Kevin Raskin, Santiago Lozano-Calderon, Karen Bernstein, John Mullen, Alex B Haynes, Francis Hornicek, Yen-Lin Chen, Edwin Choy
PURPOSE: Chordomas are malignant tumors arising from remnant notochordal tissue. Despite improved local control with pre-/postoperative radiation therapy (RT), the progression free survival (PFS) and overall survival (OS) remains poor in patients with high-risk features. Chordoma has been identified to express and activate PDGFR signaling. We conducted a phase I trial to identify the maximum tolerated dose (MTD), safety, and feasibility of nilotinib with RT as either preoperative or definitive treatment for patients with high-risk chordoma...
August 2, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/30075971/qualitative-analysis-of-clinician-experience-in-utilising-the-burn-tool-burns-risk-assessment-for-neglect-or-abuse-tool-in-clinical-practice
#14
Stephen Mullen, Harriet D Quinn-Scoggins, Diane Nuttall, Alison M Kemp
INTRODUCTION: The BuRN-Tool (Burns Risk assessment for Neglect or abuse Tool) is a clinical prediction tool (CPT) aiding the identification of child maltreatment in children with burn injuries. The tool has been derived from systematic reviews and epidemiological studies, validated and is under-going an implementation evaluation. Clinician opinion on the use of this CPT is a key part of its evaluation. OBJECTIVES: To explore the experience of emergency clinicians use of the BuRN-Tool in an emergency department (ED)...
July 31, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/30075881/variability-in-the-management-recommendations-given-for-high-risk-breast-lesions-detected-on-image-guided-core-needle-biopsy-at-u-s-academic-institutions
#15
Eniola Falomo, Catherine Adejumo, Kathryn A Carson, Susan Harvey, Lisa Mullen, Kelly Myers
The purpose of this study was to describe and compare the management recommendations provided in the setting of a high-risk lesion diagnosed on core needle biopsy of the breast at academic institutions across the United States. We contacted breast imagers at U.S. academic institutions via email and asked them to complete a voluntary online survey. The survey consisted of eight questions regarding the management recommendations given when core biopsy yields various high-risk lesions. We received survey responses from 41 of the 59 institutions contacted (69% response rate)...
June 27, 2018: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/30061417/-osterix-functions-downstream-of-anti-m%C3%A3-llerian-hormone-signaling-to-regulate-m%C3%A3-llerian-duct-regression
#16
Rachel D Mullen, Ying Wang, Bin Liu, Emma L Moore, Richard R Behringer
In mammals, the developing reproductive tract primordium of male and female fetuses consists of the Wolffian duct and the Müllerian duct (MD), two epithelial tube pairs surrounded by mesenchyme. During male development, mesenchyme-epithelia interactions mediate MD regression to prevent its development into a uterus, oviduct, and upper vagina. It is well established that transforming growth factor-β family member anti-Müllerian hormone (AMH) secreted from the fetal testis and its type 1 and 2 receptors expressed in MD mesenchyme regulate MD regression...
August 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30060766/detection-of-variants-in-dystroglycanopathy-associated-genes-through-the-application-of-targeted-whole-exome-sequencing-analysis-to-a-large-cohort-of-patients-with-unexplained-limb-girdle-muscle-weakness
#17
Katherine Johnson, Marta Bertoli, Lauren Phillips, Ana Töpf, Peter Van den Bergh, John Vissing, Nanna Witting, Shahriar Nafissi, Shirin Jamal-Omidi, Anna Łusakowska, Anna Kostera-Pruszczyk, Anna Potulska-Chromik, Nicolas Deconinck, Carina Wallgren-Pettersson, Sonja Strang-Karlsson, Jaume Colomer, Kristl G Claeys, Willem De Ridder, Jonathan Baets, Maja von der Hagen, Roberto Fernández-Torrón, Miren Zulaica Ijurco, Juan Bautista Espinal Valencia, Andreas Hahn, Hacer Durmus, Tracey Willis, Liwen Xu, Elise Valkanas, Thomas E Mullen, Monkol Lek, Daniel G MacArthur, Volker Straub
BACKGROUND: Dystroglycanopathies are a clinically and genetically heterogeneous group of disorders that are typically characterised by limb-girdle muscle weakness. Mutations in 18 different genes have been associated with dystroglycanopathies, the encoded proteins of which typically modulate the binding of α-dystroglycan to extracellular matrix ligands by altering its glycosylation. This results in a disruption of the structural integrity of the myocyte, ultimately leading to muscle degeneration...
July 30, 2018: Skeletal Muscle
https://www.readbyqxmd.com/read/30059417/screening-for-autism-spectrum-disorder-profiles-of-children-who-are-missed
#18
Chloe Beacham, Morganne Reid, Jessica Bradshaw, Meena Lambha, Lindsey Evans, Scott Gillespie, Cheryl Klaiman, Shana S Richardson
OBJECTIVE: To characterize children presenting with concerns for autism spectrum disorder (ASD) missed by parent-report screeners and to examine benefits of a combined screening approach with the Modified Checklist for Autism in Toddlers, Revised (M-CHAT-R) and the Ages and Stages Questionnaire, Third Edition (ASQ-3). METHODS: Participants included were 154 children aged 16 to 42 months presenting for an evaluation at an autism center. Caregivers completed the M-CHAT-R, ASQ-3, and a demographic questionnaire...
July 26, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/30059332/considerations-for-systemic-and-topical-treatment-of-morganella-morganii-septicemia-arising-from-maggot-infestation
#19
Ian Lambourne McCulloch, Cody L Mullens, Janice Shreve, Arif R Sarwari, Cristiane M Ueno
INTRODUCTION: Live maggot infestation (myiasis) of wounds can present a host of ailments. Loosely associated with maggot excreta, Morganella morganii is a widespread, gram-negative rod bacterium commonly found in the intestinal tracts of humans. M morganii has been observed as being pathogenic, particularly in nosocomial and postoperative environments, as well as in immunosuppressed and elderly populations. CASE REPORT: Herein, the authors present a rare, previously unreported case of M morganii septicemia (as confirmed by positive blood culture), secondary to myiasis of the lower extremities...
June 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/30056230/assessing-uptake-of-antimicrobials-by-zea-mays-l-and-prevalence-of-antimicrobial-resistance-genes-in-manure-fertilized-soil
#20
Rachel A Mullen, Jerod J Hurst, Kayla M Naas, Lauren M Sassoubre, Diana S Aga
Manure-borne antimicrobials and antimicrobial resistance genes (ARGs) are of environmental concern due to their potential to be transferred into the food-web via plant-uptake. In this study, Zea mays L. seeds were grown in three different soil conditions: soil without dairy manure, dairy manure-amended soil, and antimicrobial spiked dairy manure-amended soil, to investigate the potential uptake of antimicrobials and ARGs present in manure. The antimicrobial spiked manure consisted of dairy manure fortified with 1 mg/Kg of each individual antimicrobial compounds belonging to the sulfonamide and tetracycline classes...
July 26, 2018: Science of the Total Environment
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