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Angela K Lucas-Herald, Petra Zürbig, Avril Mason, Esther Kinning, Catriona E Brown, Bahareh Mansoorian, William Mullen, Syed Faisal Ahmed, Christian Delles
BACKGROUND: Progeria-like syndromes offer a unique insight into ageing. Here we present the case of a boy affected with mandibuloacral dysplasia and compound heterozygous mutations in ZMPSTE24. METHODS: Capillary electrophoresis-mass spectroscopy was used for proteome analysis to analyse peptides previously found to be differentially regulated in chronic kidney disease (273 peptides defining the CKD273 classifier), coronary artery disease (238 peptides defining the CAD238 classifier) and ageing (116 peptides defining the AGE116 classifier)...
December 13, 2018: Proteomics. Clinical Applications
Ayelet Harel-Gadassi, Edwa Friedlander, Maya Yaari, Benjamin Bar-Oz, Smadar Eventov-Friedman, David Mankuta, Nurit Yirmiya
Background: The aim of this study was to examine the long-term risk for autism spectrum disorders (ASD) in individuals who are born preterm and full-term using both observational instruments and parental reports. Neonatal risk factors and developmental characteristics associated with ASD risk were also examined. Method: Participants included 110 preterm children (born at a gestational age of ≤ 34 weeks) and 39 full-term children assessed at ages 18, 24, and 36 months...
2018: Autism Research and Treatment
Jirka Cops, Wilfried Mullens, Frederik H Verbrugge, Quirine Swennen, Bart De Moor, Carmen Reynders, Joris Penders, Ruth Achten, Ann Driessen, Amélie Dendooven, Jean-Michel Rigo, Dominique Hansen
Venous congestion is an important contributor to worsening renal function in heart failure and the cardiorenal syndrome. In patients, it is difficult to study the effects of isolated venous congestion on organ function. In this study, the consequences of isolated abdominal venous congestion on morphology and function of the kidneys, liver and heart were studied in a rat model. Twelve sham-operated (SHAM) male Sprague Dawley rats were compared to eleven inferior vena cava-constricted (IVCc) rats for twenty-one weeks...
December 10, 2018: Scientific Reports
Pieter Martens, Petra Nijst, Matthias Dupont, Wilfried Mullens
BACKGROUND: Progressive plasma volume (PV) expansion is a hallmark of chronic heart failure (HF), ultimately contributing to decompensated heart failure. Monitoring PV might offer prognostic information and might be a target for tailored therapy. METHODS: The correlation between technetium-(99 Tc)-labeled red blood cell measured PV and calculated PV was first determined in a validation cohort. The relationship between PV-status (PVS; a marker how much actual PV deviated from the ideal PV) and outcome was analyzed using cox-proportional modeling in a prospective CHF-population (the outcome cohort)...
December 4, 2018: Journal of Cardiac Failure
Tommy Nyberg, Koveela Govindasami, Goska Leslie, Tokhir Dadaev, Elizabeth Bancroft, Holly Ni Raghallaigh, Mark N Brook, Nafisa Hussain, Diana Keating, Andrew Lee, Romayne McMahon, Angela Morgan, Andrea Mullen, Andrea Osborne, Reshma Rageevakumar, Zsofia Kote-Jarai, Rosalind Eeles, Antonis C Antoniou
BACKGROUND: The homeobox B13 (HOXB13) G84E mutation has been recommended for use in genetic counselling for prostate cancer (PCa), but the magnitude of PCa risk conferred by this mutation is uncertain. OBJECTIVE: To obtain precise risk estimates for mutation carriers and information on how these vary by family history and other factors. DESIGN, SETTING, AND PARTICIPANTS: Two-fold: a systematic review and meta-analysis of published risk estimates, and a kin-cohort study comprising pedigree data on 11983 PCa patients enrolled during 1993-2014 from 189 UK hospitals and who had been genotyped for HOXB13 G84E...
December 7, 2018: European Urology
Lorenzo Gigli, Shigeki Kawai, Roberto Guerra, Nicola Manini, Rémy Pawlak, Xinliang Feng, Klaus Müllen, Pascal Ruffieux, Roman Fasel, Erio Tosatti, Ernst Meyer, Andrea Vanossi
Metal-surface physisorbed graphene nanoribbons (GNRs) constitute mobile nanocontacts whose interest is simultaneously mechanical, electronic, and tribological. Previous work showed that GNRs adsorbed on Au(111) generally slide smoothly and superlubrically owing to incommensurability of their structures. We address here the nanomechanics of detachment, such as realized when one end is picked up and lifted by an AFM cantilever. AFM nanomanipulations and molecular-dynamics (MD) simulations identify two successive regimes, characterized by (i) a progressively increasing local bending, accompanied by the smooth sliding of the adhered part, followed by (ii) a stick-slip dynamics involving sudden bending relaxation associated to intermittent jumps of the remaining adhered GNR segment and tail end...
December 10, 2018: ACS Nano
Klaus Müllen, Chang Liu, Shaobo Zhang, Jianhao Li, Jie Wei, Meizhen Yin
Precision phototheranostics, including photoacoustic imaging and photothermal therapy, requires stable photothermal agents. Developing photothermal agents with high stability and high photothermal conversion efficiency (PTCE) remains a considerable challenge in biomedical applications. Herein, we introduce a new photothermal agent based on water-soluble quaterrylenediimide (QDI) that can self-assemble into nanoparticles (QDI-NPs) in aqueous solution. Incorporation of polyethylene glycol (PEG) into the QDI core significantly enhances both physiological stability and biocompatibility of QDI-NPs...
December 7, 2018: Angewandte Chemie
Hirotake Komatsu, Colin A Cook, Nelson Gonzalez, Leonard Medrano, Mayra Salgado, Feng Sui, Junfeng Li, Fouad Kandeel, Yoko Mullen, Yu-Chong Tai
Cell transplantation is a promising treatment for complementing lost function by replacing new cells with a desired function, e.g., pancreatic islet transplantation for diabetics. To prevent cell obliteration, oxygen supply is critical after transplantation, especially until the graft is sufficiently re-vascularized. To supply oxygen during this period, we developed a chemical-/electrical-free implantable oxygen transporter that delivers oxygen to the hypoxic graft site from ambient air by diffusion potential...
November 22, 2018: Biofabrication
Lucja T Bundy, Regine Haardörfer, Michelle C Kegler, Shadé Owolabi, Carla J Berg, Cam Escoffery, Tess Thompson, Patricia Dolan Mullen, Rebecca Williams, Mel Hovell, Tanya Kahl, Dayanne Harvey, Adrianne Price, Donnie House, Becky W Booker, Matthew W Kreuter
Introduction: Given homes are now a primary source of secondhand smoke exposure (SHS) in the US, research-tested interventions that promote smoke-free homes should be evaluated in real-world settings to build the evidence-base for dissemination. This study describes outcome evaluation results from a dissemination and implementation study of a research-tested program to increase smoke-free home rules through US 2-1-1 helplines. Methods: Five 2-1-1 organizations, chosen through a competitive application process, were awarded grants of up to $70,000...
December 5, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Alik S Widge, Matthew Boggess, Alexander P Rockhill, Andrew Mullen, Shivani Sheopory, Roman Loonis, Daniel K Freeman, Earl K Miller
Oscillations of the brain's local field potential (LFP) may coordinate neural ensembles and brain networks. It has been difficult to causally test this model or to translate its implications into treatments, because there are few reliable ways to alter LFP oscillations. We developed a closed-loop analog circuit to enhance brain oscillations by feeding them back into cortex through phase-locked transcranial electrical stimulation. We tested the system in a rhesus macaque with chronically implanted electrode arrays, targeting 8-15 Hz (alpha) oscillations...
2018: PloS One
Ian Lambourne McCulloch, Cody L Mullens, Kristen M Hardy, Jon S Cardinal, Cristiane M Ueno
Open abdominal surgery continues to be most commonly complicated by postoperative herniation at the incision line. In 2012, Novitsky et al described a novel hernia repair technique that utilized a transversus abdominis release coupled with a posterior (retrorectus) component separation (TAR-PCS) of the ventral abdominal wall. Early reports attest to the versatility and low recurrence rate of this technique, particularly when repairing large and complex defects. We present a rare case of herniation below the linea arcuate (LAH) following repair via TAR-PCS...
December 3, 2018: Annals of Plastic Surgery
Miek Smeets, Bert Aertgeerts, Wilfried Mullens, Joris Penders, Jan Vercammen, Stefan Janssens, Bert Vaes
BACKGROUND: Heart failure (HF) imposes a burden for patients and health economics. General practitioners (GPs) are confronted with the broadest range of HF management. Although guidelines exist, they are not fully implemented in the Belgian health care system. METHODS: We will conduct a non-randomised, non-controlled prospective observational trial (six months follow-up) to implement a multifaceted intervention in Belgian general practice to support GPs in the implementation of evidence-based HF guidelines...
December 3, 2018: Acta Cardiologica
Julie Early, Juliane Ollinger, Crystal Darby, Torey Alling, Steven Mullen, Allen Casey, Ben Gold, Jason Ochoada, Todd Wiernicki, Thierry Masquelin, Carl F Nathan, Philip Hipskind, Tanya Parish
To find new inhibitors of Mycobacterium tuberculosis that have novel mechanisms of action, we miniaturized a high throughput screen to identify compounds which disrupt pH homeostasis. We adapted and validated a 384-well format assay to determine intrabacterial pH using a ratiometric green fluorescent protein. We screened 89k small molecules under non-replicating conditions and confirmed 556 hits that reduced intrabacterial pH (below pH 6.5). We selected five compounds that were active in the screen and also showed some activity against non-replicating bacteria in a 4-stress model, but with no (or greatly reduced) activity against replicating bacteria...
December 1, 2018: ACS Infectious Diseases
Daniel Raemer, Alexander Hannenberg, Ann Mullen
No abstract text is available yet for this article.
November 28, 2018: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
Ibtissam Talhaoui, Manuel Bernal, Janet R Mullen, Hugo Dorison, Benoit Palancade, Steven J Brill, Gerard Mazón
The repair of double-stranded DNA breaks (DSBs) by homologous recombination involves the formation of branched intermediates that can lead to crossovers following nucleolytic resolution. The nucleases Mus81-Mms4 and Yen1 are tightly controlled during the cell cycle to limit the extent of crossover formation and preserve genome integrity. Here we show that Yen1 is further regulated by sumoylation and ubiquitination. In vivo, Yen1 becomes sumoylated under conditions of DNA damage by the redundant activities of Siz1 and Siz2 SUMO ligases...
November 27, 2018: Nature Communications
Yong-Li Zhong, Ed Cleator, Zhijian Liu, Jianguo Yin, William J Morris, Mahbub Alam, Brian Bishop, Aaron M Dumas, John Edwards, Adrian Goodyear, Peter Mullens, Zhiguo Jake Song, Michael Shevlin, David A Thaisrivongs, Hongming Li, Edward C Sherer, Ryan D Cohen, Jingjun Yin, Lushi Tan, Nobuyoshi Yasuda, John Limanto, Antony Davies, Kevin R Campos
An asymmetric synthesis of HCV NS5B nucleoside polymerase inhibitor (1) is described. This novel route features several remarkably diastereoselective and high yielding transformations, including construction of the all carbon quaternary stereogenic center at C-2 via a thermodynamic aldol reaction. Subsequent glycosylation reaction with activated uracil via C-1 phosphate, and installation of the cyclic phosphate group using an achiral phosphorous (III) reagent followed by oxidation provides 1.
November 26, 2018: Journal of Organic Chemistry
Chirik Wah Lau, Pieter Martens, Seppe Lambeets, Matthias Dupont, Wilfried Mullens
BACKGROUND: Sacubitril/valsartan significantly reduced heart failure(HF) hospitalisations and mortality in the PARADIGM-HF-trial. However real-world data on symptomatic and functional improvement are lacking. METHODS: Between December 2016 and January 2018, we retrospectively collected baseline and follow-up data including New York Heart Association (NYHA)-functional class and Cardio-pulmonary exercise data(CPET) in all HF-patients receiving sacubitril/valsartan...
November 25, 2018: Acta Cardiologica
Judith S Mercer, Debra A Erickson-Owens, Sean C L Deoni, Douglas C Dean, Jennifer Collins, Ashley B Parker, Meijia Wang, Sarah Joelson, Emily N Mercer, James F Padbury
OBJECTIVE: To evaluate whether placental transfusion influences brain myelination at 4 months of age. STUDY DESIGN: A partially blinded, randomized controlled trial was conducted at a level III maternity hospital in the US. Seventy-three healthy term pregnant women and their singleton fetuses were randomized to either delayed umbilical cord clamping (DCC, >5 minutes) or immediate clamping (ICC, <20 seconds). At 4 months of age, blood was drawn for ferritin levels...
December 2018: Journal of Pediatrics
Jürgen Weippert, Jakob Hauns, Julian Bachmann, Artur Böttcher, Xuelin Yao, Bo Yang, Akimitsu Narita, Klaus Müllen, Manfred M Kappes
Temperature Programmed Desorption (TPD) spectroscopy was used to determine the binding energies of polycyclic aromatic hydrocarbons C n H m (22 ≤ n ≤ 60) with highly oriented pyrolytic graphite. These energies were then used to estimate the dispersive graphite interlayer cohesion by means of a refined extrapolation method proposed by Björk et al. This yields a cohesion energy of 44.0 ± 3.8 meV per carbon atom. We discuss some limits of the TPD-based approach and contrast our values with previous determinations of the interlayer cohesion energy of graphite...
November 21, 2018: Journal of Chemical Physics
Jose A Aznar-Moreno, Rosario Sánchez, Satinder K Gidda, Enrique Martínez-Force, Antonio J Moreno-Pérez, Mónica Venegas Calerón, Rafael Garcés, Robert T Mullen, Joaquín J Salas
Sunflower seeds ( Helianthus annuus L.) accumulate large quantities of triacylglycerols (TAG) between 12 and 28 days after flowering (DAF). This is the period of maximal acyl-acyl carrier protein (acyl-ACP) thioesterase activity in vitro , the enzymes that terminate the process of de novo fatty acid synthesis by catalyzing the hydrolysis of the acyl-ACPs synthesized by fatty acid synthase. Fatty acid thioesterases can be classified into two families with distinct substrate specificities, namely FatA and FatB...
2018: Frontiers in Plant Science
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