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https://www.readbyqxmd.com/read/30073843/modeling-the-hiv-1-antiretroviral-therapeutic-drug-interaction
#1
Michael H Cynamon, Ernest N Damianopoulos
To model the ART (antiretroviral therapeutic) drug interaction with the HIV-1 virus, a two-domain model is proposed that separates HIV-1 into a stable non-proliferating domain where the virus is integrated into the host resting memory CD4+ t cells; and, a second domain where the virus is in the blood in a rapidly reproductive state. ART inhibits blood HIV-1 reproduction levels sufficient to prevent progression to the AIDS end-stage, the principal goal of ART. There are 25 FDA approved antiretroviral drugs toward this goal grouped into 6 classes: NRTIs (nucleoside/nucleotide inhibitors), NNRTIs (non-nucleoside/nucleotide inhibitors), PIs (protease inhibitors), FIs (fusion inhibitors), CCR5s (chemokine cell receptor 5 antagonists), and INSTIs (integrase inhibitors)...
August 3, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29973042/time-resolved-measurements-of-nitric-oxide-nitrogen-dioxide-and-nitrous-acid-in-an-occupied-new-york-home
#2
Shan Zhou, Cora J Young, Trevor C VandenBoer, Shawn F Kowal, Tara F Kahan
Indoor oxidizing capacity in occupied residences is poorly understood. We made simultaneous continuous time-resolved measurements of ozone (O3 ), nitric oxide (NO), nitrogen dioxide (NO2 ), and nitrous acid (HONO) for two months in an occupied detached home with gas appliances in Syracuse, NY. Indoor NO and HONO mixing ratios were higher than those outdoors, whereas O3 was much lower (sub-ppbv) indoors. Cooking led to peak NO, NO2 , and HONO levels 20-100 times greater than background levels; HONO mixing ratios of up to 50 ppbv were measured...
July 24, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29945465/depressive-symptoms-prospectively-predict-cardiovascular-disease-among-older-adults-findings-from-the-maine-syracuse-longitudinal-study
#3
Emily Ap Haigh, Olivia E Bogucki, Peter J Dearborn, Michael A Robbins, Merrill F Elias
A recent meta-analysis identified a prospective association between depression and cardiovascular disease; however, there was no association for studies with long-term follow-up periods. The literature has primarily focused on baseline depression status or symptoms, which may not capture the chronic nature of depression. This study examined the prospective relationship between depressive symptoms and cardiovascular disease up to 15 years later in 274 cardiovascular disease-free older adults. Depressive and anxiety symptoms, mean arterial pressure, and cardiovascular disease status were assessed...
June 1, 2018: Journal of Health Psychology
https://www.readbyqxmd.com/read/29926789/poorer-visual-acuity-is-associated-with-declines-in-cognitive-performance-across-multiple-cognitive-domains-the-maine-syracuse-longitudinal-study
#4
Peter J Dearborn, Merrill F Elias, Kevin J Sullivan, Cara E Sullivan, Michael A Robbins
OBJECTIVES: Prior studies have found associations between visual acuity (VA) and cognitive function. However, these studies used a limited range of cognitive measures and did not control for cardiovascular disease risk factors (CVD-RFs) and baseline function. The primary objective of this study was to analyze the associations of VA and cognitive performance using a thorough neuropsychological test battery. METHODS: This study used community-dwelling sample data across the sixth (2001-2006) and seventh (2006-2010) waves of the Maine-Syracuse Longitudinal Study (n=655)...
June 21, 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29889853/projected-climate-and-agronomic-implications-for-corn-production-in-the-northeastern-united-states
#5
Rishi Prasad, Stephan Kpoti Gunn, Clarence Alan Rotz, Heather Karsten, Greg Roth, Anthony Buda, Anne M K Stoner
Corn has been a pillar of American agriculture for decades and continues to receive much attention from the scientific community for its potential to meet the food, feed and fuel needs of a growing human population in a changing climate. By midcentury, global temperature increase is expected to exceed 2°C where local effects on heat, cold and precipitation extremes will vary. The Northeast United States is a major dairy producer, corn consumer, and is cited as the fastest warming region in the contiguous U...
2018: PloS One
https://www.readbyqxmd.com/read/29785703/a-cross-sectional-study-evaluating-the-use-of-free-clinics-in-syracuse-ny-patient-demographics-and-barriers-to-accessing-healthcare-in-traditional-settings
#6
Simone Arvisais-Anhalt, Matthew MacDougall, Michael Rosenthal, Peter Congelosi, Daniel F Farrell, Paula Rosenbaum
Free clinics provide healthcare to underserved patient populations, playing a critical role in the medical safety-net. Syracuse, New York has notable racial, socioeconomic, and educational disparities and is home to four free clinics. Little is known about these clinics' patient population. This study attempts to better define this population and the barriers they face accessing traditional care. We developed a 27-question survey investigating patient demographics, barriers to traditional healthcare, and experience at local free clinics...
May 21, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29761082/associations-between-type-2-diabetes-mellitus-and-arterial-stiffness-a-prospective-analysis-based-on-the-maine-syracuse-study
#7
Merrill F Elias, Georgina E Crichton, Peter J Dearborn, Michael A Robbins, Walter P Abhayaratna
Background: The aim of this study was to investigate prospective associations between type 2 diabetes mellitus status and the gold standard non-invasive method for ascertaining arterial stiffness, carotid femoral pulse wave velocity. Methods: The prospective analysis employed 508 community-dwelling participants (mean age 61 years, 60% women) from the Maine-Syracuse Longitudinal Study. Pulse wave velocity at wave 7 (2006-2010) was compared between those with type 2 diabetes mellitus at wave 6 (2001-2006) ( n = 52) and non-diabetics at wave 6 ( n = 456), with adjustment for demographic factors, cardiovascular risk factors and lifestyle- and pulse wave velocity-related factors...
March 2018: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/29623668/generational-differences-in-medical-education-can-we-all-just-get-along-mind-the-gap-generational-differences-in-medical-education-by-alliance-for-clinical-education-geoffrey-a-talmon-and-gary-l-beck-dallaghan-editors-gegensatz-press-north-syracuse-new-york
#8
https://www.readbyqxmd.com/read/29551338/sirolimus-in-patients-with-clinically-active-systemic-lupus-erythematosus-resistant-to-or-intolerant-of-conventional-medications-a-single-arm-open-label-phase-1-2-trial
#9
Zhi-Wei Lai, Ryan Kelly, Thomas Winans, Ivan Marchena, Ashwini Shadakshari, Julie Yu, Maha Dawood, Ricardo Garcia, Hajra Tily, Lisa Francis, Stephen V Faraone, Paul E Phillips, Andras Perl
BACKGROUND: Patients with systemic lupus erythematosus have T-cell dysfunction that has been attributed to the activation of the mammalian target of rapamycin (mTOR). Rapamycin inhibits antigen-induced T-cell proliferation and has been developed as a medication under the generic designation of sirolimus. We assessed safety, tolerance, and efficacy of sirolimus in a prospective, biomarker-driven, open-label clinical trial. METHODS: We did a single-arm, open-label, phase 1/2 trial of sirolimus in patients with active systemic lupus erythematosus disease unresponsive to, or intolerant of, conventional medications at the State University of New York Upstate Medical University (Syracuse, NY, USA)...
March 24, 2018: Lancet
https://www.readbyqxmd.com/read/29232999/using-synthetic-controls-to-evaluate-the-effect-of-unique-interventions-the-case-of-say-yes-to-education
#10
Robert Bifulco, Ross Rubenstein, Hosung Sohn
BACKGROUND: "Place-based" scholarships seek to improve student outcomes in urban school districts and promote urban revitalization in economically challenged cities. Say Yes to Education is a unique district-wide school reform effort adopted in Syracuse, NY, in 2008. It includes full-tuition scholarships for public and private universities, coupled with extensive wraparound support services in schools. OBJECTIVES: This study uses synthetic control methods to evaluate the effect of Say Yes on district enrollment and graduation rates...
December 2017: Evaluation Review
https://www.readbyqxmd.com/read/28929576/systolic-orthostatic-hypotension-is-related-to-lowered-cognitive-function-findings-from-the-maine-syracuse-longitudinal-study
#11
Rachael V Torres, Merrill F Elias, Georgina E Crichton, Gregory A Dore, Adam Davey
The aim of the present study was to examine the relationship between orthostatic changes in blood pressure (BP) and cognition, with consideration given to cardiovascular risk factors and lifestyle variables. The cross-sectional analysis included 961 community-dwelling participants of the Maine-Syracuse Longitudinal Study, for whom BP clinic measures (five sitting, five recumbent, and five standing) were obtained. Eighteen percent of participants had orthostatic hypotension (fall in systolic BP ≥20 mm Hg or diastolic BP ≥10 mm Hg upon standing) and 6% had orthostatic hypertension (rise in systolic BP ≥20 mm Hg)...
December 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28861603/pleasantness-of-olfactory-and-trigeminal-stimulants-in-different-italian-regions
#12
Elena Cantone, Andrea Ciofalo, Jan Vodicka, Valentina Iacono, Ioannis Mylonakis, Bruno Scarpa, Massimiliano Russo, Maurizio Iengo, Marco de Vincentiis, Alessandro Martini, Giancarlo Ottaviano
Although individuals categorize odors according to their pleasantness, experience may also influence odor perception-a phenomenon that partially explains why different populations perceive odors differently. Italy, which comprises 20 regions, is characterized by very different cultures. In the present study, we investigated for the first time how Italian regional differences can affect odor perception. 254 healthy volunteers coming from northern, central, southern Italy, and Sicily, one of the two major Italian islands, were recruited in Padua, Rome, Naples, and Syracuse, respectively...
November 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28833191/exploring-spatially-varying-relationships-between-children-s-lead-poisoning-and-environmental-factors
#13
Liyang Shao, Lianjun Zhang, Zhen Zhen
Children's lead poisoning continues to compromise children's health and development, particularly in the inner cities of the United States. We applied a global Poisson model, a Poisson with random effects model, and a geographically weighted Poisson regression (GWPR) model to deal with the spatial dependence and heterogeneity of the number of children's lead poisoning cases in Syracuse, New York. We used three environmental factors-the building year (i.e., the year of construction) of houses, the town taxable value of houses, and the soil lead concentration-averaged at the census block level to explore the spatially varying relationships between children's lead poisoning and environmental factors...
September 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28791510/error-propagation-in-spatial-modeling-of-public-health-data-a-simulation-approach-using-pediatric-blood-lead-level-data-for-syracuse-new-york
#14
Monghyeon Lee, Yongwan Chun, Daniel A Griffith
Lead poisoning produces serious health problems, which are worse when a victim is younger. The US government and society have tried to prevent lead poisoning, especially since the 1970s; however, lead exposure remains prevalent. Lead poisoning analyses frequently use georeferenced blood lead level data. Like other types of data, these spatial data may contain uncertainties, such as location and attribute measurement errors, which can propagate to analysis results. For this paper, simulation experiments are employed to investigate how selected uncertainties impact regression analyses of blood lead level data in Syracuse, New York...
April 2018: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28787305/age-modifies-the-relation-between-intraindividual-measurement-to-measurement-variation-in-blood-pressure-and-cognitive-function-the-maine-syracuse-study
#15
Gregory A Dore, Merrill F Elias, Georgina E Crichton, Michael A Robbins
BACKGROUND: There is evidence to suggest that intraindividual variability in blood pressure (BP IIV) may be superior to mean BP for predicting cognitive function, taken from both within a single visit and between-visits. BP IIV increases with age in studies of persons middle-aged and older. The aim was therefore to investigate age by BP IIV (SBP and DBP) interactions with regard to cognitive functioning while considering medication class and polypharmacy, which may also affect BP IIV with advancing age...
February 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/28762678/-anticorruption-in-syracuse-italy
#16
EDITORIAL
Paolo Emilio Russo
No abstract text is available yet for this article.
August 1, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28729383/definitions-and-end-points-for-interventional-studies-for-arteriovenous-dialysis-access
#17
Gerald A Beathard, Charmaine E Lok, Marc H Glickman, Ahmed A Al-Jaishi, Donna Bednarski, David L Cull, Jeffery H Lawson, Timmy C Lee, Vandana D Niyyar, Donna Syracuse, Scott O Trerotola, Prabir Roy-Chaudhury, Surendra Shenoy, Margo Underwood, Haimanot Wasse, Karen Woo, Theodore H Yuo, Thomas S Huber
This paper is part of the Clinical Trial Endpoints for Dialysis Vascular Access Project of the American Society of Nephrology Kidney Health Initiative. The purpose of this project is to promote research in vascular access by clarifying trial end points which would be best suited to inform decisions in those situations in which supportive clinical data are required. The focus of a portion of the project is directed toward arteriovenous access. There is a potential for interventional studies to be directed toward any of the events that may be associated with an arteriovenous access' evolution throughout its life cycle, which has been divided into five distinct phases...
March 7, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28708839/tumor-necrosis-factor-dynamically-regulates-the-mrna-stabilome-in-rheumatoid-arthritis-fibroblast-like-synoviocytes
#18
Konstantinos Loupasakis, David Kuo, Upneet K Sokhi, Christopher Sohn, Bethany Syracuse, Eugenia G Giannopoulou, Sung Ho Park, Hyelim Kang, Gunnar Rätsch, Lionel B Ivashkiv, George D Kalliolias
During rheumatoid arthritis (RA), Tumor Necrosis Factor (TNF) activates fibroblast-like synoviocytes (FLS) inducing in a temporal order a constellation of genes, which perpetuate synovial inflammation. Although the molecular mechanisms regulating TNF-induced transcription are well characterized, little is known about the impact of mRNA stability on gene expression and the impact of TNF on decay rates of mRNA transcripts in FLS. To address these issues we performed RNA sequencing and genome-wide analysis of the mRNA stabilome in RA FLS...
2017: PloS One
https://www.readbyqxmd.com/read/28605296/filling-out-the-forms-health-literacy-among-the-uninsured
#19
Sandra D Lane, Sally J Huntington, Lynn-Beth Satterly, Robert A Rubinstein, Robert H Keefe, Amaus Project Student Researchers
This study addresses health literacy among patients at a free clinic in Syracuse, NY. Researchers conducted chart reviews of 600 patients and qualitative interviews with 22 patients and 7 providers. Most clinic patients had a high school, or higher, level education and no difficulty with reading comprehension. Nevertheless, a majority had at least some difficulty with comprehending and following through on health information. For many interviewees, the greatest difficulty was completing the required forms for entitlement programs...
September 2017: Social Work in Health Care
https://www.readbyqxmd.com/read/28388517/a-cost-benefit-analysis-of-a-pellet-boiler-with-electrostatic-precipitator-versus-conventional-biomass-technology-a-case-study-of-an-institutional-boiler-in-syracuse-new-york
#20
Jonathan I Levy, Leiran Biton, Philip K Hopke, K Max Zhang, Lisa Rector
BACKGROUND: Biomass facilities have received increasing attention as a strategy to increase the use of renewable fuels and decrease greenhouse gas emissions from the electric generation and heating sectors, but these facilities can potentially increase local air pollution and associated health effects. Comparing the economic costs and public health benefits of alternative biomass fuel, heating technology, and pollution control technology options provides decision-makers with the necessary information to make optimal choices in a given location...
July 2017: Environmental Research
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