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Cold injury

Harumitsu Hirata, Valentina Dallacasagrande, Kamila Mizerska, Evguenia Ivakhnitskaia, Mark I Rosenblatt
Purpose: Previously we found two types of corneal neurons that we hypothesized to play an important role in tearing. One type is called low threshold-cold sensitive plus dry sensitive (LT-CS + DS), and the other is termed high threshold-cold sensitive plus dry sensitive (HT-CS + DS). The present study examined critical stimuli influencing the activity of these neurons to elucidate environmental factors that may trigger this ocular reflex. Methods: Single corneal neurons were extracellularly recorded from the trigeminal ganglia in response to ocular stimuli that mimic environmental conditions one encounters in daily life...
August 1, 2018: Investigative Ophthalmology & Visual Science
J F Willms, O Boss, E Keller
BACKGROUND: Fever control plays a key role in therapy of patients with acute brain injury. The infusion of cold saline could serve as an alternative or additional method for targeted temperature management. However, it is difficult to estimate the amount of fluid required to achieve normothermia merely on the basis of body weight. There is no standardized load management regarding the administration of cold saline, and no closed-loop systems based on continuous temperature-controlled feedback are available...
August 10, 2018: Neurocritical Care
Chong Xue, Huanyu Lu, Ying Liu, Jianbin Zhang, Jiye Wang, Wenjing Luo, Wenbin Zhang, Jingyuan Chen
Trans -ferulic acid-4-β-glucoside (C16 H20 O₉, TFA-4β-G) is a monomer extracted from the Chinese medicine called radix aconiti carmichaeli (Fuzi). To date, research on this substance is lacking. Here, we found that trans -ferulic acid-4-β-glucoside effectively promoted cold acclimatization in mice via increased heat production and alleviation of oxidative stress in a cold environment. Thus, our work indicates that ferulic acid-4-β-glucoside is a potential therapeutic candidate for prevention and treatment of cold stress injury...
August 8, 2018: International Journal of Molecular Sciences
Rui Li, Lixing Zhang, Liu Wang, Lin Chen, Ruirui Zhao, Jiping Sheng, Lin Shen
Chilling stress is the main constraint in tomato (Solanum lycopersicum) production, as this is a chilling-sensitive horticultural crop. The highly conserved C-repeat binding factors (CBFs) are cold-response system components found in many species. In this study, we generated slcbf1 mutants using the CRISPR/Cas9 system and investigated the role of SlCBF1 in tomato plant chilling tolerances. The slcbf1 mutants exhibited more severe chilling injury symptoms with higher electrolyte leakage and malondialdehyde levels than wild type (WT) plants...
August 10, 2018: Journal of Agricultural and Food Chemistry
Ryan Patel, Mateusz Kucharczyk, Carlota Montagut-Bordas, Stevie Lockwood, Anthony H Dickenson
BACKGROUND: The term 'irritable nociceptor' was coined to describe neuropathic patients characterised by evoked hypersensitivity and preservation of primary afferent fibres. Oxcarbazepine is largely ineffectual in an overall patient population but has clear efficacy in a sub-group with the irritable nociceptor profile. We examine whether neuropathy in rats induced by spinal nerve injury shares overlapping pharmacological sensitives with the irritable nociceptor phenotype using drugs that target sodium channels...
August 9, 2018: European Journal of Pain: EJP
Andrew J Shepherd, Aaron D Mickle, Judith P Golden, Madison R Mack, Carmen M Halabi, Annette D de Kloet, Vijay K Samineni, Brian S Kim, Eric G Krause, Robert W Gereau, Durga P Mohapatra
Peripheral nerve damage initiates a complex series of structural and cellular processes that culminate in chronic neuropathic pain. The recent success of a type 2 angiotensin II (Ang II) receptor (AT2R) antagonist in a phase II clinical trial for the treatment of postherpetic neuralgia suggests angiotensin signaling is involved in neuropathic pain. However, transcriptome analysis indicates a lack of AT2R gene ( Agtr2 ) expression in human and rodent sensory ganglia, raising questions regarding the tissue/cell target underlying the analgesic effect of AT2R antagonism...
August 6, 2018: Proceedings of the National Academy of Sciences of the United States of America
Dawlat A Sayed, Amel M Soliman, Sohair R Fahmy
OBJECTIVE: evaluate the antiulcer healing effect of echinochrome pigment (Ech 5 and 10 mg/kg) extracted from sea urchin (Paracentrotus lividus). METHODS: Severe gastric ulceration induced in rats by administration of indomethacin in combination with cold stress (IND + CS) for 2 h. The antiulcer effect of Ech was indicated by determination of gastric juice volume, gastric juice acidity, and ulcer index as well as determination of gastric malondialdhyde (MDA), glutathione (GSH), catalase (CAT), glutathione-S-transferase (GST), superoxide dismutase (SOD), nitric oxide (NO) activities...
August 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Suboot Hairat, Vinay Kumar Baranwal, Paramjit Khurana
Role of plant nsLTP in biotic stress is well reported; however, their role during abiotic stress is far from clear. This study comprises genome-wide identification of LTPs and characterizes the regulation and function of two Triticum aestivum lipid transfer proteins, TaLTP40 and TaLTP75, under stresses that influence membrane fluidity. A total of 105 LTP gene family members have been identified. The selected LTPs for functional validation were highly expressed during salt, cold and drought stress. Further, selected LTPs showed differential expression thermotolerant and thermosusceptible wheat cultivars...
July 27, 2018: Plant Physiology and Biochemistry: PPB
Konra Mueller, Matthew S Kokotilo, Jodi Carter, Aducio Thiesen, Karen L Madsen, Jacek Studzinski, Rachel G Khadaroo, Thomas A Churchill
We have developed a novel, intraluminal preservation solution that is tailored to the metabolic requirements of the intestine. This organ-specific solution addresses many of the problems associated with low temperature organ storage including energy, oxidative and osmotic stresses. However, conservation of energy levels remains one of the most difficult obstacles to overcome due to the inherent sensitivity of the mucosa to ischemia. Creatine-loading has become a popular and scientifically proven method of augmenting energy reserves in athletes performing anaerobic burst work activities...
August 1, 2018: Cryobiology
Ramy Boles, Justin P Gawaziuk, Nora Cristall, Sarvesh Logsetty
OBJECTIVE: To describe frostbite (freezing cold injured tissue) in children and intrinsic (psychological and behavioral) and extrinsic (meteorological and safety hazard) factors related to the injury. METHODS: Retrospective chart review of children <18 years old referred to a regional pediatric hospital for frostbite, to determine the demographics, environment, and risk factors related to injuries. RESULTS: 47 patients met the inclusion criteria...
July 30, 2018: Burns: Journal of the International Society for Burn Injuries
Mathias Ströhle, Simon Rauch, Philipp Lastei, Monika Brodmann Maeder, Hermann Brugger, Peter Paal
Ströhle, Mathias, Simon Rauch, Philipp Lastei, Monika Brodmann Maeder, Hermann Brugger, and Peter Paal. Frostbite injuries in the Austrian Alps: a retrospective 11-year national registry study. High Alt Med Biol 00:000-000, 2018. OBJECTIVES: Frostbite is a cold injury mostly affecting the extremities. The objective of this study was to reveal the incidence of frostbite injuries in the Austrian Alps, to search for frostbite risk factors, and thereby optimize prevention and treatment. METHODS: Out-of-hospital data in the National Registry of Alpine Accidents from January 1, 2005, to December 31, 2015, were screened for frostbite injuries...
August 1, 2018: High Altitude Medicine & Biology
Kumar Jayant, Isabella Reccia, A M James Shapiro
Nowadays liver transplantation is considered as the treatment of choice for patients presenting with the end-stage liver disease. However, the scarcity of suitable donor organs limits the delivery of care in a timely manner leading to the deaths of patients while on the waiting list. Recently, the concept of ex-situ normothermic machine perfusion (NMP) has emerged as an alternative to the standard organ preservation technique, static cold storage (SCS) and promises to not only restore the normal metabolic activity but attempts to recondition the marginal livers back to the pristine state which are otherwise more susceptible to ischemic injury and foster poor post-transplant outcomes...
July 31, 2018: Expert Review of Gastroenterology & Hepatology
Y Xian, B Li, P Pan, Y Wang, X Pei, Y Yang
BACKGROUND: Ovarian cryopreservation by vitrification and transplantation are useful methods to recover female fertility after radiotherapy and chemotherapy. As type II programmed cell death, autophagy plays important roles in ovarian follicle development, ovarian follicle atresia and anti-stress injury. OBJECTIVE: The potential role of autophagy in ovarian vitrification was investigated. MATERIALS AND METHODS: Mouse ovaries were cryopreserved by vitrification, and autophagy was treated, after which the ovarian histology was checked, and ovarian follicles were counted...
May 2018: Cryo Letters
Emine Burcu Çığşar, Cetin Karadag, Canan Tanik, Abdurrahman Aydin, Ali Dokucu
BACKGROUND AND AIM: Necrotizing enterocolitis (NEC) is a severe gastrointestinal inflammatory disease associated with high rates of morbidity and mortality. Its pathophysiology includes hypoxic-ischemic injury that may be related to oxygen-derived free radical formation. Sesamol is considered to be an antioxidant and free radical scavenger with anti-inflammatory effects. The aim of this study is to investigate the effects of sesamol in a neonatal rat model of NEC. MATERIALS AND METHODS: The study included 1-d-old Wistar albino rat pups (n = 34) that were randomly divided into four groups: Group 1 (NEC), group 2 (NEC + intraperitoneal sesamol), group 3 (NEC + oral sesamol), and a control group...
July 29, 2018: Journal of Maternal-fetal & Neonatal Medicine
Moman A Mohammad, Sasha Koul, J Gustav Smith, Marco Noc, Irene Lang, Michael Holzer, Peter Clemmensen, Ulf Jensen, Thomas Engstrøm, Håkan Arheden, Stefan James, Bertil Lindahl, Bernhard Metzler, David Erlinge
The association of markers of myocardial injury and dysfunction with infarct size (IS) and ejection fraction (EF) are well documented. However, limited data are available on the newer high-sensitivity troponin assays and comparison with morphologic and functional assessment with cardiac magnetic resonance imaging. We aimed to examine the associations of high-sensitivity cardiac Troponin-T (hs-cTnT), creatine kinase MB iso-enzyme (CKMB), and N-terminal pro B-type Natriuretic Peptide (NT-proBNP) to IS and EF at 6 months...
June 5, 2018: American Journal of Cardiology
Francois Faitot, Camille Besch, Benjamin Lebas, Pietro Addeo, Bernard Ellero, Marie-Lorraine Woehl-Jaegle, Izzie-Jacques Namer, Philippe Bachellier, Guy Freys
BACKGROUND & AIMS: ischemia-reperfusion injury impacts early liver graft function. Interleukin 6 (IL6) as early as at reperfusion has shown to predict in-hospital complications but its impact on vascular complications and long-term outcomes is not ascertained. METHODS: a retrospective study was conducted on all consecutive patients transplanted during a 6-year period to define significant early systemic inflammatory response (ESIR). Main endpoint was 3-year graft survival...
July 25, 2018: Clinical Transplantation
Renata J Troncoso, Daniel E Herzberg, Constanza S Meneses, Heine Y Müller, Marianne P Werner, Hedie Bustamante
Background: Tail docking of dairy cows is a painful procedure that affects animal welfare level. The aims of this study were first to evaluate the response to mechanical and thermal stimulation, and second to determine the superficial temperature of the stump of tail-docked dairy cows. Methods: One hundred and sixty-four dairy cows were enrolled. From these, 133 cows were assigned to the tail-docked (TD) group and 31 cows were selected as control animals. The following sensory assessments to evaluate pain in tail-docked cows were performed...
2018: PeerJ
Wenjiao Zhu, Ke Shi, Ruimin Tang, Xiaoying Mu, Jinghui Cai, Min Chen, Xiong You, Qing Yang
Low temperature causes a negative impact on plant growth and development, but plants evolve a series of mechanisms to respond to chilling stress, and one of them is CBF [C-repeat (CRT)/dehydration-responsive element (DRE) binding factor] gene family which has been well studied in different crops. In this paper, a new CBF1 gene, named as SpCBF1 , was isolated from frost-tolerant Solanum pinnatisectum by PCR and analyzed for its function in cold-tolerance by over-expression technique. The ORF of SpCBF1 was 666 bp long and encoded a protein of 221 amino acids with a predicted molecular mass 24...
July 2018: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
Pradeep Kumar Sudheeran, Oleg Feygenberg, Dalia Maurer, Noam Alkan
Red fruits were suggested to be tolerant to cold. To understand cold-storage tolerance of red mango fruit that were subjected to sunlight at the orchard, mango cv. Shelly from inside (green fruit) or outside (red fruit) the tree canopy was stored for 3 weeks at 5, 8 or 12 °C and examined for flavonoids, antioxidant, volatiles and tolerance to biotic and abiotic stress. Red fruit from the outer canopy showed significant increases in total anthocyanin and flavonoids, and antioxidant activity. Ripening parameters for red and green mango fruit were similar at harvest and during storage...
July 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
C Humbrecht, D Kientz, C Gachet
Since the late sixties, platelet concentrates are transfused to patients presenting with severe thrombocytopenia, platelet function defects, injuries, or undergoing surgery, to prevent the risk of bleeding or to treat actual hemorrhage. Current practices differ according to the country or even in different hospitals and teams. Although crucial advances have been made during the last decades, questions and debates still arise about the right doses to transfuse, the use of prophylactic or therapeutic strategies, the nature and quality of PC, the storage conditions, the monitoring of transfusion efficacy and the microbiological and immunological safety of platelet transfusion...
July 20, 2018: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
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