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Acute Respiratory Failure in adults

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https://www.readbyqxmd.com/read/30105627/severe-atypical-pneumonia-in-critically-ill-patients-a-retrospective-multicenter-study
#1
S Valade, L Biard, V Lemiale, L Argaud, F Pène, L Papazian, F Bruneel, A Seguin, A Kouatchet, J Oziel, S Rouleau, N Bele, K Razazi, O Lesieur, F Boissier, B Megarbane, N Bigé, N Brulé, A S Moreau, A Lautrette, O Peyrony, P Perez, J Mayaux, E Azoulay
BACKGROUND: Chlamydophila pneumoniae (CP) and Mycoplasma pneumoniae (MP) patients could require intensive care unit (ICU) admission for acute respiratory failure. METHODS: Adults admitted between 2000 and 2015 to 20 French ICUs with proven atypical pneumonia were retrospectively described. Patients with MP were compared to Streptococcus pneumoniae (SP) pneumonia patients admitted to ICUs. RESULTS: A total of 104 patients were included, 71 men and 33 women, with a median age of 56 [44-67] years...
August 13, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/30100769/epidemiology-prognostic-factors-and-outcome-of-trauma-patients-admitted-in-a-brazilian-intensive-care-unit
#2
Gabriella F Pogorzelski, Taline Aal Silva, Thamara Piazza, Tomás M Lacerda, Fernando Ac Spencer Netto, Amaury Cesar Jorge, Péricles Ad Duarte
Background: Trauma is a major cause of hospital admissions and is associated with manifold complications and high mortality rates. However, data on intensive care unit (ICU) admissions are scarce in developing and low-income countries, where its incidence has been increasing. Objectives: To analyze epidemiological and clinical factors and outcomes in adult trauma patients admitted to the ICU of a public teaching hospital in a developing country as well as to identify risk factors for complications in the ICU...
2018: Open Access Emergency Medicine: OAEM
https://www.readbyqxmd.com/read/30095800/can-elective-spine-surgery-be-performed-safely-among-nonagenarians-analysis-of-a-national-inpatient-database-in-japan
#3
Takeshi Oichi, Yasushi Oshima, Hiroki Matsui, Kiyohide Fushimi, Sakae Tanaka, Hideo Yasunaga
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To compare morbidity and mortality between nonagenarians and other older adult patients who underwent elective spine surgery. SUMMARY OF BACKGROUND DATA: There is a lack of information of the perioperative risks of nonagenarians undergoing spine surgery. METHODS: Data of patients aged ≥65 years who underwent elective spine surgery from July 2010 to March 2013 were extracted from the Diagnosis Procedure Combination database, a nationwide administrative inpatient database in Japan...
August 7, 2018: Spine
https://www.readbyqxmd.com/read/30095746/randomized-study-of-early-continuous-positive-airways-pressure-in-acute-respiratory-failure-in-children-with-impaired-immunity-scarf-isrctn82853500
#4
Mark J Peters, Rachel Agbeko, Peter Davis, Nigel Klein, Zohra Zenasi, Amy Jones, Christine Mackerness, Susan George, Paul Veys, Samiran Ray, Paul R Mouncey, David A Harrison, Kathy Rowan
OBJECTIVES: Previous trials in adults with impaired immunity and respiratory failure suggest that early noninvasive ventilation avoids endotracheal intubation and improves survival. No randomized clinical trials have addressed this question in children. DESIGN: We undertook an open, parallel-group randomized trial in three pediatric hospitals. SUBJECTS: Children with impaired immunity and acute respiratory failure defined as tachypnoea (> 90th centile); a new requirement for supplemental oxygen; and new chest radiograph infiltrates...
August 7, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/30095498/epidemiology-of-cause-of-death-in-pediatric-acute-respiratory-distress-syndrome
#5
Jasmine C Dowell, Kaushik Parvathaneni, Neal J Thomas, Robinder G Khemani, Nadir Yehya
OBJECTIVES: Investigations of acute respiratory distress syndrome in adults suggest hypoxemia is an uncommon cause of death. However, the epidemiology of death in pediatric acute respiratory distress syndrome is not well characterized. We aimed to describe the cause, mode, and timing of death in pediatric acute respiratory distress syndrome nonsurvivors. We hypothesized that most deaths would be due to nonpulmonary factors, rather than hypoxemia. DESIGN: Retrospective, decedent-only analysis...
August 7, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/30083347/lung-thorax-compliance-measured-during-a-spontaneous-breathing-trial-is-a-good-index-of-extubation-failure-in-the-surgical-intensive-care-unit-a-retrospective-cohort-study
#6
Yugo Okabe, Takehiko Asaga, Sayuri Bekku, Hiromi Suzuki, Kanae Kanda, Takeshi Yoda, Tomohiro Hirao, Gotaro Shirakami
Background: Extubation failure is associated with mortality and morbidity in the intensive care unit. Ventilator weaning protocols have been introduced, and extubation is conducted based on the results of a spontaneous breathing trial. Room for improvement still exists in extubation management, and additional objective indices may improve the safety of the weaning and extubation process. Static lung-thorax compliance reflects lung expansion difficulty that is caused by several conditions, such as atelectasis, fibrosis, and pleural effusion...
2018: Journal of Intensive Care
https://www.readbyqxmd.com/read/30080702/drowning-in-fresh-or-salt-water-respective-influence-on-respiratory-function-in-a-matched-cohort-study
#7
Pierre Michelet, Marion Dusart, Laurence Boiron, Julien Marmin, Tarak Mokni, Anderson Loundou, Mathieu Coulange, Thibaut Markarian
INTRODUCTION: For the most severe drowned patients, hypoxemia represents one of the major symptoms. As the influence of the type of water (fresh or salt water) on respiratory function is still unclear, the primary endpoint of this multicenter study was to compare hypoxemia according to the type of water. METHODS: Medical records of adult patients who experienced a drowning event and were consequently admitted to 10 ICU for acute respiratory failure were analyzed retrospectively using data collected over three consecutive summer periods...
August 3, 2018: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/30076119/invasive-aspergillosis-in-patients-admitted-to-the-intensive-care-unit-with-severe-influenza-a-retrospective-cohort-study
#8
Alexander F A D Schauwvlieghe, Bart J A Rijnders, Nele Philips, Rosanne Verwijs, Lore Vanderbeke, Carla Van Tienen, Katrien Lagrou, Paul E Verweij, Frank L Van de Veerdonk, Diederik Gommers, Peter Spronk, Dennis C J J Bergmans, Astrid Hoedemaekers, Eleni-Rosalina Andrinopoulou, Charlotte H S B van den Berg, Nicole P Juffermans, Casper J Hodiamont, Alieke G Vonk, Pieter Depuydt, Jerina Boelens, Joost Wauters
BACKGROUND: Invasive pulmonary aspergillosis typically occurs in an immunocompromised host. For almost a century, influenza has been known to set up for bacterial superinfections, but recently patients with severe influenza were also reported to develop invasive pulmonary aspergillosis. We aimed to measure the incidence of invasive pulmonary aspergillosis over several seasons in patients with influenza pneumonia in the intensive care unit (ICU) and to assess whether influenza was an independent risk factor for invasive pulmonary aspergillosis...
July 31, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30050640/determinants-and-outcomes-associated-with-decisions-to-deny-intensive-care-unit-admission-in-tunisian-icu
#9
Rania Bouneb, Menel Mellouli, Maha Dardouri, Houda Ben Soltane, Imed Chouchene, Mohamed Boussarsar
Introduction: intensive care unit (ICU) beds are a scarce resource, and admissions may require prioritization when demand exceeds supply. However, there are few data regarding both outcomes of admitted patients to intensive care unit (ICU) in comparison with outcomes of not admitted patients. The aim of this study was to assess reasons and factors associated to refusal of admission to ICU as well as the impact on mortality at 28 days and patients' outcomes. Methods: Single-center, cross-sectional descriptive study conducted in 8-bed Medical ICU at a Tunisian University hospital...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/30045171/early-predictors-of-abdominal-hemorrhage-among-critically-ill-patients-with-pancreatitis-a-prospective-cohort-study
#10
Eduardo Labarca, Felix Zubia, Enrique Maraví-Poma, Felipe Martinez
OBJECTIVE: To establish incidence, risk factors, and prognostic implications of abdominal hemorrhage (AH) among critically ill patients with acute pancreatitis (AP). METHODS: Prospective cohort study in 46 intensive care units aimed at describing the characteristics of critically ill patients with AP (Epidemiología de la Pancreatitis Aguda en Medicina Intensiva Study). Adult patients with AP and at least 1 organ failure were included. The presence of AH was established either by using computed tomography, magnetic resonance imaging, or by direct visualization during surgery...
July 24, 2018: Pancreas
https://www.readbyqxmd.com/read/30043501/best-life-bringing-ecmo-simultion-to-life-how-medical-simulation-improved-regional-ecmo-program
#11
Mateusz Puślecki, Marcin Ligowski, Marek Dąbrowski, Sebastian Stefaniak, Małgorzata Ładzińska, Piotr Ładziński, Aleksander Pawlak, Marcin Zieliński, Agata Dąbrowska, Aniela Artyńska, Mariusz Gezela, Paweł Sobczyński, Łukasz Szarpak, Bartłomiej Perek, Marek Jemielity
BACKGROUND: The implemented "ECMO for Greater Poland" program takes full advantage of the ECMO (extracorporeal membrane oxygenation) perfusion therapy to promote health for 3.5 million inhabitants in the region (Greater Poland). The predominant subjects of implementation are patients with hypothermia, with severe reversible respiratory failure (RRF) and treatment of other critical states leading to heart failure such as sudden cardiac arrest, cardiogenic shock or acute intoxication...
July 25, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30026931/study-protocol-for-the-anesthesiology-control-tower-feedback-alerts-to-supplement-treatments-actfast-3-trial-a-pilot-randomized-controlled-trial-in-intraoperative-telemedicine
#12
Stephen Gregory, Teresa M Murray-Torres, Bradley A Fritz, Arbi Ben Abdallah, Daniel L Helsten, Troy S Wildes, Anshuman Sharma, Michael S Avidan
Background : Each year, over 300 million people undergo surgical procedures worldwide. Despite efforts to improve outcomes, postoperative morbidity and mortality are common. Many patients experience complications as a result of either medical error or failure to adhere to established clinical practice guidelines. This protocol describes a clinical trial comparing a telemedicine-based decision support system, the Anesthesiology Control Tower (ACT), with enhanced standard intraoperative care. Methods : This study is a pragmatic, comparative effectiveness trial that will randomize approximately 12,000 adult surgical patients on an operating room (OR) level to a control or to an intervention group...
2018: F1000Research
https://www.readbyqxmd.com/read/30024538/fatal-pulmonary-infection-with-respiratory-syncytial-virus-in-an-immunocompromised-adult-patient-a-case-report
#13
Qi Wang, Wei Li, Danhua Qu, Tong Xin, Peng Gao
RATIONALE: Respiratory syncytial virus (RSV) is a single-stranded negative-sense RNA virus that belongs to the family of paramyxoviruses. RSV is the most common pathogen that causes acute lower respiratory tract infection in infants and young children. However, its incidence in immunocompromised adults remains unclear. In the present study, we report an adult patient with chronic nephropathy, who received long-term immunosuppressants and died of rapid respiratory failure due to RSV infection...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30011073/identification-of-potential-pathogenic-viruses-in-patients-with-acute-myocarditis-using-next-generation-sequencing
#14
Suguru Takeuchi, Jun-Ichi Kawada, Yusuke Okuno, Kazuhiro Horiba, Takako Suzuki, Yuka Torii, Kazushi Yasuda, Atsushi Numaguchi, Taichi Kato, Yoshiyuki Takahashi, Yoshinori Ito
Myocarditis is an inflammatory disease of the myocardium, leading to cardiac dysfunction and heart failure. Although viral infections are considered to be the most common etiology of myocarditis, identification of the causative virus is still challenging. Recently, next-generation sequencing (NGS) has been applied in the diagnosis of infectious diseases. The aim of the present study was to comprehensively analyze potential pathogenic microorganisms using NGS in sera of patients with myocarditis. Twelve pediatric and five adult patients hospitalized for acute myocarditis were included...
July 16, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29997953/comparison-of-clinical-manifestations-and-treatment-outcome-according-to-age-groups-in-adult-patients-with-miliary-tuberculosis
#15
Jaehee Lee, Jae Kwang Lim, Eun Jin Kim, Deok Heon Lee, Yu Kyung Kim, Seung Soo Yoo, Shin Yup Lee, Seung Ick Cha, Jae Yong Park, Chang Ho Kim
Background: After the introduction of chemotherapy, miliary tuberculosis (TB) has been more prevalent in adults than in children. However, adult patients have a wide age range and may have different characteristics across the age span. Thus, clinical manifestations and treatment outcome may differ according to age groups in adult patients with miliary TB. However, there is limited information regarding this issue. Methods: Adult patients with miliary TB were retrospectively reviewed and were categorized into young (18-40 years), middle-aged (41-64 years), and old adults (≥65 years)...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29977768/idiopathic-pulmonary-fibrosis-patient-supported-with-extracorporeal-membrane-oxygenation-for-403-days-while-waiting-for-a-lung-transplant-a-case-report
#16
Nao Umei, Shingo Ichiba, Atsuhiro Sakamoto
According to the Extracorporeal Life Support Organization, the average duration of veno-venous extracorporeal membrane oxygenation (V-V ECMO) in adults with acute respiratory failure is 10.5-13.5 days. Some patients on V-V ECMO may not recover in such a short period of time, and recently, there have been more reports of prolonged V-V ECMO. However, we do not know how long it is feasible to wait for native lung recovery or lung transplant (LTx) with the use of ECMO. We describe a patient with acute exacerbation of idiopathic pulmonary fibrosis supported by ECMO for 403 days while waiting for a LTx...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29946477/the-acute-ambulance-cpap-use-treatment-effect-and-economics-feasibility-study-a-pilot-randomised-controlled-trial-of-prehospital-cpap-for-acute-respiratory-failure
#17
Gordon W Fuller, Steve Goodacre, Samuel Keating, Gavin Perkins, Matthew Ward, Andy Rosser, Imogen Gunson, Joshua Miller, Mike Bradburn, Praveen Thokala, Tim Harris, Andrew Carson, Maggie Marsh, Cindy Cooper
Background: Acute respiratory failure (ARF) is a common and life-threatening medical emergency. Standard prehospital management involves controlled oxygen therapy and disease-specific ancillary treatments. Continuous positive airway pressure (CPAP) is a potentially beneficial alternative treatment that could be delivered by emergency medical services. However, it is uncertain whether this treatment could work effectively in United Kingdom National Health Service (NHS) ambulance services and if it represents value for money...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29934099/a-double-blind-randomized-controlled-trial-of-gabapentin-vs-placebo-for-acute-pain-management-in-critically-ill-patients-with-rib-fractures
#18
Eliza E Moskowitz, Lucin Garabedian, Kimberly Harden, Emily Perkins-Pride, Menilik Asfaw, Candice Preslaski, Kiara N Liasia, Ryan Lawless, Clay Cothren Burlew, Fredric Pieracci
INTRODUCTION: Achieving adequate pain control for rib fractures remains challenging; prescription of alternatives to narcotics is imperative to curtail the current opioid epidemic. Although gabapentin has shown promise following elective thoracic procedures, its efficacy in patients with rib fractures remains unstudied. We hypothesized that gabapentin, as compared to placebo, would both improve acute pain control and decrease narcotic use among critically ill patients with rib fractures...
June 9, 2018: Injury
https://www.readbyqxmd.com/read/29926544/clinical-effectiveness-of-high-flow-nasal-cannula-in-hypoxaemic-patients-during-bronchoscopic-procedures
#19
Sang Mi Chung, Ju Whan Choi, Young Seok Lee, Jong Hyun Choi, Jee Youn Oh, Kyung Hoon Min, Gyu Young Hur, Sung Yong Lee, Jae Jeong Shim, Kyung Ho Kang
BACKGROUND: Bronchoscopy is a useful diagnostic and therapeutic tool. However, the clinical use of high-flow nasal cannula (HFNC) in adults with acute respiratory failure for diagnostic and invasive procedures has not been well evaluated. We present our experiences of well-tolerated diagnostic bronchoscopy as well as cases of improved saturation in hypoxaemic patients after a therapeutic bronchoscopic procedure. METHODS: We retrospectively reviewed data of hypoxaemic patients who had undergone bronchoscopy for diagnostic or therapeutic purposes from October 2015 to February 2017...
June 19, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29924026/management-of-adult-onset-methylmalonic-acidemia-with-hypotonia-and-acute-respiratory-failure-a-case-report
#20
Zhanqi Zhao, Chan-Ching Chu, Mei-Yun Chang, Hao-Tai Chang, Yeong-Long Hsu
RATIONALE: Methylmalonic acidemia (MMA) is an autosomal recessive disease of organic acidemia. PATIENT CONCERNS: We report a 26-year-old male who presented with metabolic acidosis, acute renal failure required hemodialysis and acute respiratory failure required mechanical ventilation support. Progressive hypotonia of muscles made weaning from mechanical ventilator difficult. DIAGNOSES: High level of serum methylmalonic acid and the mut genotype sequences confirmed the diagnosis of this adult-onset MMA...
June 2018: Medicine (Baltimore)
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