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Global filtration rate

Arkadiusz Lubas, Robert Ryczek, Artur Maliborski, Przemysław Dyrla, Longin Niemczyk, Stanisław Niemczyk
Renal perfusion, which depends on cardiac function, is a factor conditioning the work of kidneys. The objective of the study was to assess the influence of cardiac function, including left ventricular contractility and relaxation, on renal cortical perfusion in patients with hypertension and chronic kidney disease treated pharmacologically. There were 63 patients (7 F and 56 M; aged 56 ± 14) with hypertension and stable chronic kidney disease enrolled into the study. Serum cystatin C, with estimated glomerular filtration rate (eGFR), ambulatory blood pressure monitoring, carotid intima-media thickness (cIMT), echocardiography with speckle tracking imaging and the calculation of global longitudinal strain (GLS), diameter of vena cava inferior (VCI), and an ultrasound dynamic tissue perfusion measurement of the renal cortex were performed...
December 4, 2018: Advances in Experimental Medicine and Biology
Michela Del Prete, François-Alexandre Buteau, Frédéric Arsenault, Nassim Saighi, Louis-Olivier Bouchard, Alexis Beaulieu, Jean-Mathieu Beauregard
PURPOSE: Peptide receptor radionuclide therapy (PRRT) is mostly administered using a fixed injected activity (IA) per cycle. This empiric regime results in highly variable absorbed doses to the critical organs and undertreatment of the majority of patients. We conceived a personalized PRRT protocol in which the IA is adjusted to deliver a prescribed absorbed dose to the kidney, with the aim to safely increase tumour irradiation. We herein report on the initial results of our prospective study of personalized PRRT, the P-PRRT Trial (NCT02754297)...
November 30, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Madelyn N Woods, Margaret E Stack, David M Fields, Susan D Shaw, Patricia A Matrai
Microplastic fibers (MPF) are a ubiquitous marine contaminant, making up to 90% of global microplastic concentrations. Imaging flow cytometry was used to measure uptake and ingestion rates of MPF by blue mussels (Mytilus edulis). Mussels were fed a diet of Rhodomonas salina and MPF concentrations up to 30 MPF mL-1 , or 0.374% of available seston. Filtration rates were greatly reduced in mussels exposed to MPF. Uptake of MPF followed a Holling's Type II functional response with 95% of the maximum rate (5227 MPF h- 1 ) occurring at 13 MPF mL-1 ...
December 2018: Marine Pollution Bulletin
Rosanna Coppo
The search of personalized treatment for a subject with immunoglobulin A nephropathy (IgAN) is appealing since the individual long-term outcome is highly variable in spite of common mild clinical signs such as microscopic haematuria, moderate proteinuria and slightly reduced glomerular filtration rate (GFR). The only risk factor considered by the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines to target corticosteroid/immunosuppressive treatment in IgAN is proteinuria persistently >1 g/day despite 3-6 months of optimized supportive care...
November 26, 2018: Nephrology, Dialysis, Transplantation
Javier A Neyra, Federica Mescia, Xilong Li, Beverley Adams-Huet, Lenar Yessayan, Jerry Yee, Robert D Toto, Orson W Moe
Introduction: Chronic kidney disease (CKD) and acute kidney injury (AKI) are strongly associated with excess morbidity and mortality and frequently co-occur in critically ill septic patients, but how their interplay affects clinical outcomes is not well elucidated. Methods: We conducted a single-center, retrospective cohort study of 2632 adult patients admitted to the intensive care unit (ICU) with severe sepsis or septic shock. Subjects were classified into 6 groups according to baseline CKD (no-CKD: estimated glomerular filtration rate [eGFR] ≥60; CKD: eGFR 15-59 ml/min per 1...
November 2018: KI Reports
Lulu Qu, Gen Zhu, Jie Ji, T P Yadav, Yijiang Chen, Guohai Yang, Hui Xu, Haitao Li
Organic pollutants are harmful to human health, which creates a global need for the development of novel and effective materials for efficiently removing contaminants. Accordingly, an efficient visible light-driven heterostructured membrane combined with oxygen-modified monolayer g-C3 N4 , graphene oxide, and nitrogen-doped carbon nanotubes (CNTs) (O-g-C3 N4 /GO/N-CNT) was successfully fabricated through electrostatic interactions and subsequent vacuum filtration. The results suggested that the O-g-C3 N4 /GO/N-CNT membrane exhibited higher degradation rate than those of O-g-C3 N4 /GO and pure O-g-C3 N4 under visible light exposure...
November 29, 2018: ACS Applied Materials & Interfaces
Eglė Tamulėnaitė, Rūta Žvirblytė, Rūta Ereminienė, Edita Žiginskienė, Eglė Ereminienė
Background and objectives : Chronic kidney disease (CKD) increases the risk of cardiovascular diseases even in its early stages and is associated with structural and functional cardiac abnormalities. The aim of this study was to use speckle-tracking echocardiography (STE) to evaluate left and right ventricle mechanics and function, markers of subclinical dysfunction in patients with end-stage renal disease (ESRD) undergoing haemodialysis. Methods : Patients with ESRD undergoing regular haemodialysis and with preserved left ventricle (LV) ejection fraction (EF) ( n = 38) were enrolled in this retrospective study...
November 13, 2018: Medicina
Katsuaki Kasahara, Yoshimitsu Gotoh, Yoshiyuki Kuroyanagi, China Nagano, Satoshi Yamakawa, Kazuki Tanaka, Asami Takeda, Osamu Uemura
BACKGROUND: The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines suggest initially using angiotensin-converting-enzyme inhibitors (ACE-Is) and/or angiotensin receptor blockers (ARBs) to treat Henoch-Schönlein purpura nephritis (HSPN). However, these guidelines might overlook the potential benefits of aggressive therapy. Therefore, we evaluated the efficacy of an HSPN protocol that primarily uses steroids and immunosuppressants, without ACE-Is or ARBs. METHODS: We determine treatment intensity based on International Study of Kidney Diseases in Children (ISKDC) grading...
November 7, 2018: Minerva Pediatrica
Yu Zang, Brecht Devleesschauwer, P Michael Bolger, Emily Goodman, Herman J Gibb
Chronic exposures to cadmium (Cd) are associated with reduced glomerular filtration rate (GFR), increasing the risk of chronic kidney disease (CKD). In support of the World Health Organization (WHO)'s initiative to estimate the global burden of foodborne diseases, a risk assessment was performed to estimate the Disability-Adjusted Life Years (DALYs) due to late-stage CKD associated with dietary exposures to cadmium. Using the distribution of population GFRs, the prevalence of CKD was calculated as the proportion of humans whose GFR fall in the ranges corresponding to Stage 4 or Stage 5 CKD...
October 22, 2018: Environmental Research
Pierre Delanaye
The prevalence of chronic kidney disease (CKD) clearly depends on its definition, and the definition used most often is the one proposed by the Kidney Disease: Improving Global Outcomes guidelines in 2012: 'CKD is defined as abnormalities of kidney structure or function, present for >3 months, with implications for health.' Abnormality of kidney function is a glomerular filtration rate (GFR) <60 mL/min/1.73 m2, and the most frequently used marker of kidney damage is the presence of albuminuria [albumin excretion rate >30 mg/24 h or albumin/creatinine ratio (ACR) >30 mg/g (or 3 mg/mmol)]...
November 12, 2018: Nephrology, Dialysis, Transplantation
Hannan Chaudery, Neil MacDonald, Tahania Ahmad, Susilo Chandra, Aida Tantri, Velayuthapillai Sivasakthi, Marzida Mansor, Ricardo Matos, Rupert M Pearse, John R Prowle
BACKGROUND: Postoperative acute kidney injury (AKI) is associated with a high mortality rate. However, the relationship among AKI, its associations, and mortality is not well understood. METHODS: Planned analysis of data was collected during an international 7-day cohort study of adults undergoing elective in-patient surgery. AKI was defined using Kidney Disease Improving Global Outcomes criteria. Patients missing preoperative creatinine data were excluded. We used multivariable logistic regression to examine the relationships among preoperative creatinine-based estimated glomerular filtration rate (eGFR), postoperative AKI, and hospital mortality, accounting for the effects of age, major comorbid diseases, and nature and severity of surgical intervention on outcomes...
November 9, 2018: Anesthesia and Analgesia
M E Ougaard, H E Jensen, I D Thuen, E G Petersen, P H Kvist
INTRODUCTION: Chronic kidney disease (CKD) is a global health concern, but the current treatments only slow down the progression. Thus an improved understanding of the pathogenesis and novel treatments of CKD are needed. The nephrotoxic nephritis (NTN) model has the potential to study the pathogenesis of CKD as it resembles human CKD. The classical treatments with angiotensin II receptor blocker (ARB) or the angiotensin-converting enzyme inhibitor (ACE I) have shown a clinical effect in CKD...
November 2018: Renal Failure
Takao Nonaka, Naoyuki Kimura, Daijiro Hori, Yusuke Sasabuchi, Mitsunori Nakano, Koichi Yuri, Masamitsu Sanui, Harunobu Matsumoto, Atsushi Yamaguchi
Objective : To investigate the predictors of acute kidney injury (AKI) following surgery for abdominal aortic aneurysm. Materials and Methods : Subjects were 642 non-hemodialysis patients (open aortic repair [OAR] group, n=453; endovascular aortic repair [EVAR] group, n=189) who underwent elective surgery between 2009 and 2015. AKI was assessed according to the Kidney Disease Improving Global Outcomes criteria. In-hospital mortality and incidence of AKI were compared between the OAR and EVAR groups. The effect of AKI on outcomes and predictors of AKI were examined in both groups...
September 25, 2018: Annals of Vascular Diseases
Bryce Tan, Narayanaswamy Venketasubramanian, Henri Vrooman, Ching-Yu Cheng, Tien Yin Wong, Christopher Chen, Saima Hilal
BACKGROUND: Low haemoglobin is highly prevalent among the elderly and has been associated with dementia. However, the mechanisms underlying this association with cognitive dysfunction, either through cerebrovascular disease or neurodegeneration, remain poorly understood. We aimed to examine the association of decreased haemoglobin levels with markers of cerebral small vessel disease (CSVD), neurodegeneration and cognitive impairment in an elderly Asian population. METHODS: A total of 796 Chinese, Malay and Indian participants aged 60 years and older from the Epidemiology of Dementia in Singapore study were included in this study...
November 6, 2018: Alzheimer's Research & Therapy
Yusuke Okabayashi, Nobuo Tsuboi, Hoichi Amano, Yoichi Miyazaki, Tetsuya Kawamura, Makoto Ogura, Ichiei Narita, Toshiharu Ninomiya, Hitoshi Yokoyama, Takashi Yokoo
OBJECTIVES: The clinical severity of IgA nephropathy (IgAN) at the time of biopsy diagnosis differs significantly among cases. One possible determinant of any such difference is the time taken for referral from the primary care physician to a nephrologist, but the definitive cause remains unclear. This study examined the contribution of the number of nephrologists per regional population as a potential social factor influencing the clinical severity at diagnosis among patients with IgAN in Japan, which has an ethnically homogeneous population...
October 31, 2018: BMJ Open
Georges Belfort
After 70 years, modern pressure-driven polymer membrane processes with liquids are mature and accepted in many industries due to their good performance, ease of scale-up, low energy consumption, modular compact construction, and low operating costs compared with thermal systems. Successful isothermal operation of synthetic membranes with liquids requires consideration of three critical aspects or "legs" in order of relevance: selectivity, capacity (i.e. permeation flow rate per unit area) and transport of mass and momentum comprising concentration polarization (CP) and fouling (F)...
October 29, 2018: Angewandte Chemie
Miklos Z Molnar, Kiran Joglekar, Yu Jiang, George Cholankeril, Mubeen Khan Mohammed Abdul, Satish Kedia, Humberto C Gonzalez, Aijaz Ahmed, Ashwani Singal, Kalyan Ram Bhamidimarri, Guruprasad Padur Aithal, Ajay Duseja, Vincent Wai-Sun Wong, Agayeva Gulnare, Puneet Puri, Satheesh Nair, James D Eason, Sanjaya K Satapathy
BACKGROUND: Nonalcoholic Steatohepatitis(NASH) is one of the top three indications for liver transplantation in western countries. It is unknown whether renal dysfunction at the time of liver transplantation has any effect on post-liver transplantation outcomes in recipients with NASH. METHODS: From the United Network for Organ Sharing-Standard Transplant Analysis and Research(UNOS-STAR) dataset, we identified 4,088 NASH recipients who received deceased donor liver transplant...
October 28, 2018: Liver Transplantation
V Mendoza-Grimón, J R Fernández-Vera, J M Hernández-Moreno, I Hernández-Brito, M P Palacios-Diaz
Livestock effluents are a nutrient supply that is beneficial for crops, so their use is essential to guarantee the sustainability of the global management of farms. Zero discharge cattle effluent management to irrigate fodder crops is a mitigation option, so it is considered a key factor for adaptation to climate change. This paper presents the result of an "on site" pilot scale (three-stage, vertical flow filtration system using lapilli). This is a low-cost solution in terms of finance and energy, which does not require the addition of chemicals, to treat a cattle effluent...
October 23, 2018: Journal of Environmental Management
M Cañadas-Garre, K Anderson, J McGoldrick, A P Maxwell, A J McKnight
BACKGROUND: Chronic kidney disease (CKD) is recognised as a global public health problem, more prevalent in older persons and associated with multiple co-morbidities. Diabetes mellitus and hypertension are common aetiologies for CKD, but IgA glomerulonephritis, membranous glomerulonephritis, lupus nephritis and autosomal dominant polycystic kidney disease are also common causes of CKD. MAIN BODY: Conventional biomarkers for CKD involving the use of estimated glomerular filtration rate (eGFR) derived from four variables (serum creatinine, age, gender and ethnicity) are recommended by clinical guidelines for the evaluation, classification, and stratification of CKD...
October 25, 2018: Journal of Translational Medicine
Lesley A Inker, Morgan E Grams, Andrew S Levey, Josef Coresh, Massimo Cirillo, John F Collins, Ron T Gansevoort, Orlando M Gutierrez, Takayuki Hamano, Gunnar H Heine, Shizukiyo Ishikawa, Sun Ha Jee, Florian Kronenberg, Martin J Landray, Katsuyuki Miura, Girish N Nadkarni, Carmen A Peralta, Dietrich Rothenbacher, Elke Schaeffner, Sanaz Sedaghat, Michael G Shlipak, Luxia Zhang, Arjan D van Zuilen, Stein I Hallan, Csaba P Kovesdy, Mark Woodward, Adeera Levin
RATIONALE & OBJECTIVE: Chronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities and hypertension with the estimated glomerular filtration rate (eGFR) and albuminuria CKD staging framework. STUDY DESIGN: Cross-sectional individual participant-level analyses in a global consortium. SETTING & STUDY POPULATIONS: 17 CKD and 38 general population and high-risk cohorts...
October 19, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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