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Global filtration rate

Mariette J Chartier, Navdeep Tangri, Paul Komenda, Randy Walld, Ina Koseva, Charles Burchill, Kari-Lynne McGowan, Allison Dart
BACKGROUND: Chronic Kidney Disease (CKD) is common and its prevalence has increased steadily over several decades. Monitoring of rates and severity of CKD across populations is critical for policy development and resource planning. Administrative health data alone has insufficient sensitivity for this purpose, therefore utilizing population level laboratory data and novel methodology is required for population-based surveillance. The aims of this study include a) develop the Manitoba CKD Cohort, b) estimate CKD prevalence, c) identify individuals at high risk of progression to kidney failure and d) determine rates of comorbid health conditions...
October 10, 2018: BMC Nephrology
Giangiuseppe Cappabianca, Domenico Paparella, Augusto D'Onofrio, Luca Caprili, Giuseppe Minniti, Massimiliano Lanzafame, Alessandro Parolari, Francesco Musumeci, Cesare Beghi
AIMS: A global outbreak of Mycobacterium chimaera infections following cardiac surgery and linked to contaminated heater-cooler units (HCUs) is currently ongoing. Neither the status of this outbreak in Italy nor the mitigation strategies adopted by adult cardiac surgery units (ACSUs) are currently known. In 2017, the Italian Society of Cardiac Surgery launched a national survey among the Italian ACSU to shed some light on this issue. METHODS: In Italy, there are 90 ACSUs across 20 regions...
October 8, 2018: Journal of Cardiovascular Medicine
Wuhua Jiang, Jiawei Yu, Jiarui Xu, Bo Shen, Yimei Wang, Zhe Luo, Chunsheng Wang, Xiaoqiang Ding, Jie Teng
BACKGROUND: The association between pre-operative cardiac catheterization and cardiac surgery associated acute kidney injury (CSA-AKI) has been reported inconsistently. The purpose of this study is to evaluate the effect of the catheterization timing and contrast media dose on the incidence of postoperative acute kidney injury. METHODS: Patients who underwent cardiac catheterization and cardiac surgery successively from January 2015 to December 2015 were prospectively enrolled in this study...
October 5, 2018: BMC Cardiovascular Disorders
Hiroshi Okada, Muhei Tanaka, Takashi Yasuda, Tadaaki Kamitani, Hisahiro Norikae, Tetsuya Fujita, Takashi Nishi, Hirokazu Oyamada, Tetsuro Yamane, Michiaki Fukui
The number of people with peripheral artery disease (PAD) has been increasing globally; therefore, it is important to explore more options to screen patients who are at a risk of developing PAD. The perfusion index (PI) represents the degree of circulation through the peripheral tissues and is measured noninvasively. We investigated the correlation between the PI and ankle-brachial index (ABI) to explore whether the PI could be used a screening tool for PAD. This cross-sectional study included 390 patients...
October 3, 2018: Heart and Vessels
Z-J Sun, X-Q Li, D-Y Chang, S-X Wang, G Liu, M Chen, M-H Zhao
AIMS: As the potential role of the complement system in diabetic nephropathy (DN) is increasingly reported, this study aimed to investigate C1q and C3c deposition as seen on renal histopathology, as well as its association with clinical and pathological parameters, in DN patients. METHODS: Renal biopsy specimens from 161 DN patients were investigated using direct immunofluorescence, light, and electron microscopy. For direct immunofluorescence, staining for C1q and C3c on fresh-frozen renal tissue was performed immediately after biopsy...
September 19, 2018: Diabetes & Metabolism
Amalia Schiavetti, Valeria Pedetti, Giulia Varrasso, Oriana Marrucci, Camilla Celani, Gianmarco Andreoli, Enea Bonci
AIM: Little data is available on long-term renal impairment in survivors from childhood sarcoma. We investigated the prevalence of renal impairment and hypertension after very long-term follow-up in survivors who reached adulthood after treatment for childhood sarcoma. METHODS: A cross-sectional single center study was performed. Outcomes included estimating glomerular filtration rate (eGFR), albuminuria, glycosuria, serum phosphate and magnesium, tubular reabsorption phosphate (TRP), chronic kidney disease (CKD) according to the "Kidney Disease: Improving Global Outcomes" (KDIGO) guidelines and blood pressure (BP)...
September 19, 2018: Pediatric Hematology and Oncology
Alberto Martini, Shivaram Cumarasamy, Alp Tuna Beksac, Ronney Abaza, Daniel D Eun, Akshay Bhandari, Ashok K Hemal, James R Porter, Ketan K Badani
BACKGROUND: Decreased functional outcome after partial nephrectomy is associated with overall mortality. OBJECTIVE: To create a model that predicts ≥25% reduction from baseline estimated glomerular filtration rate (eGFR) in patients undergoing robot-assisted partial nephrectomy (RAPN) and to investigate the role of acute kidney injury (AKI) in this patient population. DESIGN, SETTING, AND PARTICIPANTS: A total of 999 patients were identified from a multi-institutional database...
September 14, 2018: European Urology
Tomáš Šálek, Alena Adamíková
The aim of this study was to provide evidence for the hypothesis that estimated glomerular filtration rate from serum Cystatin C (eGFRcys) is better to be determined for all elderly type 2 diabetes mellitus (T2DM) patients based on eGFRcys upward and downward reclassification rate for hypothetical metformin dose reduction by eGFRcys at the GFR decision point of 45 mL/min/1.73 m2 . A total of 265 consecutive T2DM elderly patients (age range 65-91 years) from outpatient diabetic clinic were included in the study...
September 15, 2018: Basic & Clinical Pharmacology & Toxicology
Kelly R McMahon, Maya Harel-Sterling, Michael Pizzi, Louis Huynh, Erin Hessey, Michael Zappitelli
BACKGROUND: Childhood cancer survivors treated with cisplatin, ifosfamide, or carboplatin are at risk for late kidney and blood pressure (BP) abnormalities. Few studies have comprehensively evaluated kidney outcomes and 24-h ambulatory BP monitoring (ABPM) in this population. We aimed to describe chemotherapy-associated acute kidney injury (AKI) and late kidney outcomes using standardized definitions. METHODS: This was a single-center longitudinal pilot study of 23 children who participated in a previous study during cisplatin, carboplatin, or ifosfamide treatment...
September 14, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Fang Wang, Kevin He, Jinwei Wang, Ming-Hui Zhao, Yi Li, Luxia Zhang, Rajiv Saran, Jennifer L Bragg-Gresham
Introduction: Chronic kidney disease (CKD) is an important noncommunicable disease globally. Overall prevalence of CKD and distribution of its stages differ between countries. We postulate that these differences may not only be due to variation in prevalence of risk factors but also their differential impact in different populations or settings. Methods: We used nationally representative data on the adult populations from both the United States (US; National Health and Nutrition Examination Survey [NHANES], 2009 to 2010, N = 5557) and China (China National Survey of CKD, 2009 to 2010, N = 46,949)...
September 2018: KI Reports
Guobin Su, Hong Xu, Emilia Riggi, Zhiren He, Liming Lu, Bengt Lindholm, Gaetano Marrone, Zehuai Wen, Xusheng Liu, David W Johnson, Juan-Jesus Carrero, Cecilia Stålsby Lundborg
Antibiotic resistance is a major global health threat. High prevalences of colonization and infection with multi-drug resistance organisms (MDROs) have been reported in patients undergoing dialysis. It is unknown if this finding extends to patients with mild and moderate/severe kidney disease. An observational study included all adult incident patients hospitalized with a discharge diagnosis of infection in four hospitals from Guangzhou, China. INCLUSION CRITERIA: Serum creatinine measurement at admission together with microbial culture confirmed infections...
September 6, 2018: Scientific Reports
Juan Betuel Ivey-Miranda, Eduardo Almeida-Gutiérrez, Gabriela Borrayo-Sánchez, Javier Antezana-Castro, Alicia Contreras-Rodríguez, Edith Liliana Posada-Martínez, Edith González-Morales, Nayeli García-Hernández, Diana Romero-Zertuche, Horacio Marquez-Gonzalez, Guillermo Saturno-Chiu
Right ventricular (RV) systolic dysfunction due to acute myocardial infarction is associated with serious complications in the short-term. Acute kidney injury (AKI) is a frequent and unrecognized complication. This study aimed to assess whether RV longitudinal strain predicts AKI and short-term prognosis in patients with RV infarction. Prospective cohort of patients with RV infarction. RV function was evaluated with global and free wall right ventricular longitudinal strain (GRVLS and FWRVLS), tricuspid annular plane systolic excursion, and tricuspid S' wave...
September 4, 2018: International Journal of Cardiovascular Imaging
Samuel N Uwaezuoke, Adaeze C Ayuk, Vivian U Muoneke, Ngozi R Mbanefo
Chronic kidney disease (CKD) in children contributes to the global health burden. The focus on using novel biomarkers to predict the onset and progression of the disease has increased tremendously over the past decade. Discovery of these biomarkers offers prospects for the early anticipation of the late stages of CKD, slowing down disease progression, and achieving better disease outcomes. The aim of this article is to classify and highlight the utility of these novel biomarkers in predicting disease-onset and progression...
July 2018: Saudi Journal of Kidney Diseases and Transplantation
Hasan Demetgul, Dilek Giray, Ali Delibas, Olgu Hallioglu
IntroductionThe aim of this study is to determine early changes in cardiac function of children with chronic kidney disease by using 2D-speckle tracking echocardiography. METHOD: The study included 38 children - 16 girls and 22 boys - diagnosed as having chronic kidney disease in the nephrology department with a glomerular filtration rate of <90 ml/minute/1.73 m2 for at least 3 months. A total of 37 - 15 girls and 22 boys - age- and sex-matched healthy children were included as the control group...
August 28, 2018: Cardiology in the Young
Anca Moţăţăianu, Smaranda Maier, Zoltan Bajko, Septimiu Voidazan, Rodica Bălaşa, Adina Stoian
BACKGROUND: Cardiac autonomic neuropathy (CAN) in diabetes is among the strongest risk markers for future global and cardiovascular mortality. The aim of this study was to analyse CAN prevalence and to compare the associations between CAN, the glycaemic control, cardiovascular risk factors, peripheral neuropathy, retinopathy and macroangiopathy in patients with type 1 (T1DM) and type 2 diabetes mellitus (T2DM). METHODS: One hundred ninety-five diabetic patients were included in this study...
August 27, 2018: BMC Neurology
Benoît Georges, Justine Huart, Jean-Marie Krzesinski, François Jouret
Metabolic acidosis is a frequent and early biological abnormality of chronic kidney disease (CKD). Chronic metabolic acidosis affects the global homeostasis of the human body, including the metabolism of bone and muscles. Numerous studies have proved a causal relationship between metabolic acidosis and accelerated CKD progression. Hence, the measure of serum bicarbonate level should be part of the systematic follow-up of CKD patients of whom glomerular filtration rate decreases below 50 ml/min/1.73m². Both screening and treatment of metabolic acidosis are easy and cheap...
August 22, 2018: Revue Médicale Suisse
Sojib Bin Zaman, Naznin Hossain, Muntasirur Rahman
BACKGROUND: Chronic kidney disease (CKD) has emerged as a public health burden globally. Obesity and long-term hyperglycaemia can initiate the renal vascular complications in patients with type 2 diabetes mellitus (T2DM). This study aimed to investigate the association of body mass index (BMI) with the CKD in patients with T2DM. METHODS: This study has used retrospective medical records, biochemical reports, and anthropometric measurements of 3,580 T2DM patients which were collected between January to December 2015 from a district hospital in Thailand...
August 2018: Diabetes & Metabolism Journal
Yuyan Tang, Haidong He, Weiqian Sun, Pin Hu, Xia Chen, Xudong Xu
Currently, there is no clear evidence that advocates the widespread use of corticosteroids for the treatment of immunoglobulin A nephropathy (IgAN) with minimal proteinuria (<1 g/day). The recent Kidney Disease: Improving Global Outcomes Clinical Practice Guideline recommends supportive corticosteroid treatment. In the present study, 45 IgAN patients with high renal pathological scores and minimal proteinuria were enrolled. The patients were randomly divided into two groups. The treatment group received methylprednisolone tablets in addition to angiotensin‑converting‑enzyme inhibitor (ACE‑I) and/or angiotensin‑receptor blocker (ARB) treatment...
August 21, 2018: Molecular Medicine Reports
Alexander Nikolay, Arnaud Léon, Klaus Schwamborn, Yvonne Genzel, Udo Reichl
A live-attenuated, human vaccine against mosquito-borne yellow fever virus has been available since the 1930s. The vaccine provides long-lasting immunity and consistent mass vaccination campaigns counter viral spread. However, traditional egg-based vaccine manufacturing requires about 12 months and vaccine supplies are chronically close to shortages. In particular, for urban outbreaks, vaccine demand can be covered rarely by global stockpiling. Thus, there is an urgent need for an improved vaccine production platform, ideally transferable to other flaviviruses including Zika virus...
October 2018: Applied Microbiology and Biotechnology
Marco Ranucci, Tommaso Aloisio, Anna Cazzaniga, Umberto Di Dedda, Chiara Gallazzi, Valeria Pistuddi
BACKGROUND: Cardiac surgery-associated acute kidney injury (AKI) is a serious complication of cardiac surgery, even when renal replacement therapy (RRT) is not required. The existing risk models for cardiac surgery associated AKI are designed to predict AKI requiring RRT (RRT-AKI). The aim of this study is to validate three risk models for the prediction of RRT-dependent and non-RRT AKI after cardiac surgery. METHODS: Retrospective analysis on 7675 consecutive adult patients undergoing cardiac surgery with cardiopulmonary bypass...
December 1, 2018: International Journal of Cardiology
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