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Jong-Kook Lee, Tudor Luchian, Yoonkyung Park
Clavaspirin peptide (CSP) is derived from the pharyngeal tissues of the tunicate Styela clava . The 23-amino acid peptide is histidine-rich and amidated at the N-terminus. CSP possesses low antimicrobial and high hemolytic activity at pH 7.4. Therefore, we designed 4 CSP analogs with substituted hydrophobic amino acids to reduce hydrophobic amino acid interactions. These modifications reduced the aggregation and cytotoxicity of the analogs at pH 7.4. The analogs also showed potent antimicrobial activity by accumulating on bacterial cell surfaces and inducing the lytic mechanism against gram-negative and gram-positive cells at pH 5...
March 20, 2018: Oncotarget
Ewelina Gowin, Danuta Januszkiewicz-Lewandowska, Roman Słowiński, Jerzy Błaszczyński, Michał Michalak, Jacek Wysocki
Differential Diagnosis of bacterial and viral meningitis remains an important clinical problem. A number of methods to assist in the diagnoses of meningitis have been developed, but none of them have been found to have high specificity with 100% sensitivity.We conducted a retrospective analysis of the medical records of 148 children hospitalized in St. Joseph Children's Hospital in Poznań. In this study, we applied for the first time the original methodology of dominance-based rough set approach (DRSA) to diagnostic patterns of meningitis data and represented them by decision rules useful in discriminating between bacterial and viral meningitis...
August 2017: Medicine (Baltimore)
Lars Hansen, Sepp de Raedt, Peter Bo Jørgensen, Bjarne Mygind-Klavsen, Bart Kaptein, Maiken Stilling
BACKGROUND: Dynamic RSA (dRSA) enables non-invasive 3D motion-tracking of bones and may be used to evaluate in-vivo hip joint kinematics including hip pathomechanics such as femoroacetabular impingement (FAI) and the biomechanical effects of arthroscopic cheilectomy and -rim trimming (ACH). The study aim was to evaluate the kinematic changes in the hip joint after ACH. METHODS: Seven non-FAI affected human cadaveric hips were CT-scanned and CT-bone models were created...
December 2017: Journal of Experimental Orthopaedics
Sara Palermo, Leonardo Lopiano, Maurizio Zibetti, Rosalba Rosato, Daniela Leotta, Martina Amanzio
BACKGROUND: Although dyskinesias-reduced-self-awareness (DRSA) in Parkinson's disease (PD) is related to deficit in metacognition, other factors, such as "Theory of Mind" (ToM), could operate. METHODS: Forty-one PD patients were assessed using the Global Awareness of Movement Disorders (GAM) and the Dyskinesias Subtracted-Index (DS-I). To study whether GAM and DS-I scores could be influenced by second-type ToM or Reading the Mind in the Eyes (RME) tasks, we conducted two multiple logistic regression analyses...
June 2017: Parkinsonism & related Disorders
Chamira Dilanka Fernando, Diyathi Tharindhi Karunaratne, Sachith Dilshan Gunasinghe, M C Dilusha Cooray, Prabuddhi Kanchana, Chandani Udawatte, Pathirage Kamal Perera
BACKGROUND: Advanced glycation end products (AGEs) and free radicals are inflammatory mediators and are implicated in many diseases such as diabetes, cancer, rheumatoid arthritis etc. Multi targeted poly herbal drug systems like Nawarathne Kalka (NK) are able to quench the overall effect of these mediators as they contain good combinations of phytochemicals that have least side effects in contrast to modern medicinal drugs. The objectives of this study were to evaluate phytochemical composition, free radical scavenging activity, cytotoxicity and the inhibitory action on the formation of AGEs by aqueous extract of NK...
July 8, 2016: BMC Complementary and Alternative Medicine
Aaron J Fisher, Jonathan W Reeves, Cyrus Chi
Expanding on recently published methods, the current study presents an approach to estimating the dynamic, regulatory effect of the parasympathetic nervous system on heart period on a moment-to-moment basis. We estimated second-to-second variation in respiratory sinus arrhythmia (RSA) in order to estimate the contemporaneous and time-lagged relationships among RSA, interbeat interval (IBI), and respiration rate via vector autoregression. Moreover, we modeled these relationships at lags of 1 s to 10 s, in order to evaluate the optimal latency for estimating dynamic RSA effects...
July 2016: Psychophysiology
Naveed Ahmad, Abdur Rab, Nisar Ahmad
Stevia rebaudiana (S. rebaudiana) is a very important species with worldwide medicinal and commercial uses. Light is one of the major elicitors that fluctuate morphogenic potential and biochemical responses. In the present study, we investigated the effect of various spectral lights on biomass accumulation and secondary metabolite production in callus cultures of S. rebaudiana. Leaf explants were placed on Murashige and Skoog (MS) medium and exposed to various spectral lights. 6-Benzyle adenine (BA) and 2, 4-dichlorophenoxy acetic acid (2, 4-D; 2...
January 2016: Journal of Photochemistry and Photobiology. B, Biology
Eleazar Gil-Herrera, Garrick Aden-Buie, Ali Yalcin, Athanasios Tsalatsanis, Laura E Barnes, Benjamin Djulbegovic
BACKGROUND: This paper explores and evaluates the application of classical and dominance-based rough set theory (RST) for the development of data-driven prognostic classification models for hospice referral. In this work, rough set based models are compared with other data-driven methods with respect to two factors related to clinical credibility: accuracy and accessibility. Accessibility refers to the ability of the model to provide traceable, interpretable results and use data that is relevant and simple to collect...
November 25, 2015: BMC Medical Informatics and Decision Making
Jong-Kook Lee, Tudor Luchian, Yoonkyung Park
Obesity is often associated with irregular dietary habits and reduced physical activity. Regular exercise induces a metabolic response that includes increased expression of various cytokines, signaling proteins and hormones, and reduced adipocyte size. In this study, mice performed a swimming exercise for 10 min/day, 5 days/week for 3 weeks. We then investigated the effect of this exercise regimen on inflammation induced by infection with drug-resistant Staphylococcus aureus strain 3089 (DRSA). In humans, DRSA causes dermatitis and pneumonitis...
November 6, 2015: Scientific Reports
Chih-Jung Chen, Yhu-Chering Huang, Cheng-Hsu Chiu
BACKGROUND: The development of non-susceptibility to glycopeptides and daptomycin in MRSA during persistent bacteraemia has become a significant therapeutic challenge. However, the in vivo evolution and mechanism of the dual resistance have remained incompletely understood. METHODS: A series of MRSA blood isolates with incremental non-susceptibility to glycopeptides and daptomycin were consecutively recovered from a bacteraemic patient who was failing chemotherapy...
November 2015: Journal of Antimicrobial Chemotherapy
Łukasz Pałkowski, Jerzy Błaszczyński, Andrzej Skrzypczak, Jan Błaszczak, Alicja Nowaczyk, Joanna Wróblewska, Sylwia Kożuszko, Eugenia Gospodarek, Roman Słowiński, Jerzy Krysiński
The progress of antimicrobial therapy contributes to the development of strains of fungi resistant to antimicrobial drugs. Since cationic surfactants have been described as good antifungals, we present a SAR study of a novel homologous series of 140 bis-quaternary imidazolium chlorides and analyze them with respect to their biological activity against Candida albicans as one of the major opportunistic pathogens causing a wide spectrum of diseases in human beings. We characterize a set of features of these compounds, concerning their structure, molecular descriptors, and surface active properties...
2015: BioMed Research International
Bibo Wang, Koren E Roach, Ashley L Kapron, Niccolo M Fiorentino, Charles L Saltzman, Madeline Singer, Andrew E Anderson
The relationship between altered tibiotalar and subtalar kinematics and development of ankle osteoarthritis is unknown, as skin marker motion analysis cannot measure articulations of each joint independently. Here, we quantified the accuracy and demonstrated the feasibility of high-speed dual fluoroscopy (DF) to measure and visualize the three-dimensional articulation (i.e., arthrokinematics) of the tibiotalar and subtalar joints. Metal beads were implanted in the tibia, talus and calcaneus of two cadavers...
May 2015: Gait & Posture
V Cijo George, D R Naveen Kumar, P K Suresh, R Ashok Kumar
Annona muricata is a naturally occurring edible plant with wide array of therapeutic potentials. In India, it has a long history of traditional use in treating various ailments. The present investigation was carried out to characterize the phytochemicals present in the methanolic and aqueous leaf extracts of A. muricata, followed by validation of its radical scavenging and DNA protection activities. The extracts were also analyzed for its total phenolic contents and subjected to HPLC analysis to determine its active metabolites...
April 2015: Journal of Food Science and Technology
H Blasco, J Błaszczyński, J C Billaut, L Nadal-Desbarats, P F Pradat, D Devos, C Moreau, C R Andres, P Emond, P Corcia, R Słowiński
BACKGROUND: Metabolomics is an emerging field that includes ascertaining a metabolic profile from a combination of small molecules, and which has health applications. Metabolomic methods are currently applied to discover diagnostic biomarkers and to identify pathophysiological pathways involved in pathology. However, metabolomic data are complex and are usually analyzed by statistical methods. Although the methods have been widely described, most have not been either standardized or validated...
February 2015: Journal of Biomedical Informatics
Antonio Boggia, Lucia Rocchi, Luisa Paolotti, Francesco Musotti, Salvatore Greco
Rural Development is a priority in Europe and it is supported by specific, financial programmes. At the same time, sustainability is the key word for the European Union to construct programmes and policies for all human activities. However, measuring sustainability of rural areas is not easy, due to their particular features. The improvement of knowledge on sustainability in rural areas is important to build long term policies and strategies for those territories. The objective of this study is the development of a decision support system based on the Dominance-based Rough Set Approach (DRSA), to assess the level of Rural Sustainable Development in specific areas...
November 1, 2014: Journal of Environmental Management
Radosław Jarząbek, Paweł Bugajski, Krzysztof Greberski, Jerzy Błaszczyński, Barbara Słowińska-Jarząbek, Ryszard Kalawski
BACKGROUND: Intensive care unit (ICU) readmission after cardiac surgery is believed to be associated with higher in-hospital mortality and may predict poor outcomes. ICU readmissions use resources and increase treatment costs. AIM: To determine reasons for readmission to ICU, evaluate outcomes in these patients, and identify factors predisposing to the need for readmission to ICU. METHODS: We retrospectively investigated a total of 2076 consecutive adult patients who underwent either isolated coronary artery bypass grafting or a valve procedure or combination of both and were discharged from our ICU between January 2008 and December 2010...
2014: Kardiologia Polska
Didem Aksoy Körpe, Özlem Darcansoy İşerı, Feride Iffet Sahin, Evren Cabi, Mehmet Haberal
The aim of this study was to comparatively evaluate antibacterial activities of methanol (MetOH) and aqueous (dw) leaf (L), root (R) and seed (S) extracts of Urtica dioica L. (Ud; stinging nettle) and Urtica pilulifera L. (Up; Roman nettle) on both food- and plant-borne pathogens, with total phenolic contents and DPPH radical scavenging activities (DRSA). MetOH extracts of leaves and roots of U. dioica had the highest DRSA. Extracts with high antibacterial activity were in the order Up-LMetOH (13/16) > Ud-SMetOH (11/16) > Up-SMetOH (9/16)...
May 2013: International Journal of Food Sciences and Nutrition
L A González, K S Schwartzkopf-Genswein, M Bryan, R Silasi, F Brown
The objective of the present work was to study space allowance in cattle during commercial long haul transport (≥400 km; n = 6,152 journeys). Surveys, delivered to livestock transport carriers, gathered information on the number, BW, and distribution of cattle by trailer compartment as well as the characteristics of the transport vehicles used. Space allowance (SA; m(2)/animal), allometric coefficient (k = SA / BW(0.6667)), and the percentage of deviation from recommended SA (DRSA; %) in the Canadian Codes of Practice were calculated for each compartment of the trailers...
October 2012: Journal of Animal Science
Kenji Hayashida, Makoto Tanaka, Kota Koizumi, Masaaki Kakiuchi
PURPOSE: The purpose of this study was to examine magnetic resonance imaging (MRI) findings and elucidate retear pattern and its characteristics after surgical repair of the rotator cuff using an arthroscopic double-row suture anchor (DRSA) method. METHODS: Forty-seven patients with complete rotator cuff tears treated by the DRSA method under arthroscopy whose repair condition was assessed by MRI approximately 12 months after the procedure were included in the study...
April 2012: Arthroscopy: the Journal of Arthroscopic & related Surgery
Francisco M Gomez-Soto, José L Puerto, José L Andrey, Francisco J Fernandez, Miguel A Escobar, Antonio A Garcia-Egido, Sotero P Romero, José A Bernal, F Gomez
BACKGROUND AND OBJECTIVE: To evaluate if consultation between specialists in Internal Medicine and family doctors (CIMFD) improves the clinical management and prognosis of patients with heart failure (HF). METHODS: HASH(0x37bb450) DESIGN: prospective case-control study (5 years of follow-up). SETTING: community-based sample within the area of a university teaching hospital. SUBJECTS: 1857 patients (> or = 14 years) diagnosed for the first time with HF (1stDxHF), in the CIMFD...
November 2008: European Journal of Internal Medicine
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