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Chamira Dilanka Fernando, Diyathi Tharindhi Karunaratne, Sachith Dilshan Gunasinghe, M C Dilusha Cooray, Prabuddhi Kanchana, Chandani Udawatte, Pathirage Kamal Perera
BACKGROUND: Advanced glycation end products (AGEs) and free radicals are inflammatory mediators and are implicated in many diseases such as diabetes, cancer, rheumatoid arthritis etc. Multi targeted poly herbal drug systems like Nawarathne Kalka (NK) are able to quench the overall effect of these mediators as they contain good combinations of phytochemicals that have least side effects in contrast to modern medicinal drugs. The objectives of this study were to evaluate phytochemical composition, free radical scavenging activity, cytotoxicity and the inhibitory action on the formation of AGEs by aqueous extract of NK...
2016: BMC Complementary and Alternative Medicine
Aaron J Fisher, Jonathan W Reeves, Cyrus Chi
Expanding on recently published methods, the current study presents an approach to estimating the dynamic, regulatory effect of the parasympathetic nervous system on heart period on a moment-to-moment basis. We estimated second-to-second variation in respiratory sinus arrhythmia (RSA) in order to estimate the contemporaneous and time-lagged relationships among RSA, interbeat interval (IBI), and respiration rate via vector autoregression. Moreover, we modeled these relationships at lags of 1 s to 10 s, in order to evaluate the optimal latency for estimating dynamic RSA effects...
July 2016: Psychophysiology
Naveed Ahmad, Abdur Rab, Nisar Ahmad
Stevia rebaudiana (S. rebaudiana) is a very important species with worldwide medicinal and commercial uses. Light is one of the major elicitors that fluctuate morphogenic potential and biochemical responses. In the present study, we investigated the effect of various spectral lights on biomass accumulation and secondary metabolite production in callus cultures of S. rebaudiana. Leaf explants were placed on Murashige and Skoog (MS) medium and exposed to various spectral lights. 6-Benzyle adenine (BA) and 2, 4-dichlorophenoxy acetic acid (2, 4-D; 2...
January 2016: Journal of Photochemistry and Photobiology. B, Biology
Eleazar Gil-Herrera, Garrick Aden-Buie, Ali Yalcin, Athanasios Tsalatsanis, Laura E Barnes, Benjamin Djulbegovic
BACKGROUND: This paper explores and evaluates the application of classical and dominance-based rough set theory (RST) for the development of data-driven prognostic classification models for hospice referral. In this work, rough set based models are compared with other data-driven methods with respect to two factors related to clinical credibility: accuracy and accessibility. Accessibility refers to the ability of the model to provide traceable, interpretable results and use data that is relevant and simple to collect...
2015: BMC Medical Informatics and Decision Making
Jong-Kook Lee, Tudor Luchian, Yoonkyung Park
Obesity is often associated with irregular dietary habits and reduced physical activity. Regular exercise induces a metabolic response that includes increased expression of various cytokines, signaling proteins and hormones, and reduced adipocyte size. In this study, mice performed a swimming exercise for 10 min/day, 5 days/week for 3 weeks. We then investigated the effect of this exercise regimen on inflammation induced by infection with drug-resistant Staphylococcus aureus strain 3089 (DRSA). In humans, DRSA causes dermatitis and pneumonitis...
November 6, 2015: Scientific Reports
Chih-Jung Chen, Yhu-Chering Huang, Cheng-Hsu Chiu
BACKGROUND: The development of non-susceptibility to glycopeptides and daptomycin in MRSA during persistent bacteraemia has become a significant therapeutic challenge. However, the in vivo evolution and mechanism of the dual resistance have remained incompletely understood. METHODS: A series of MRSA blood isolates with incremental non-susceptibility to glycopeptides and daptomycin were consecutively recovered from a bacteraemic patient who was failing chemotherapy...
November 2015: Journal of Antimicrobial Chemotherapy
Łukasz Pałkowski, Jerzy Błaszczyński, Andrzej Skrzypczak, Jan Błaszczak, Alicja Nowaczyk, Joanna Wróblewska, Sylwia Kożuszko, Eugenia Gospodarek, Roman Słowiński, Jerzy Krysiński
The progress of antimicrobial therapy contributes to the development of strains of fungi resistant to antimicrobial drugs. Since cationic surfactants have been described as good antifungals, we present a SAR study of a novel homologous series of 140 bis-quaternary imidazolium chlorides and analyze them with respect to their biological activity against Candida albicans as one of the major opportunistic pathogens causing a wide spectrum of diseases in human beings. We characterize a set of features of these compounds, concerning their structure, molecular descriptors, and surface active properties...
2015: BioMed Research International
Bibo Wang, Koren E Roach, Ashley L Kapron, Niccolo M Fiorentino, Charles L Saltzman, Madeline Singer, Andrew E Anderson
The relationship between altered tibiotalar and subtalar kinematics and development of ankle osteoarthritis is unknown, as skin marker motion analysis cannot measure articulations of each joint independently. Here, we quantified the accuracy and demonstrated the feasibility of high-speed dual fluoroscopy (DF) to measure and visualize the three-dimensional articulation (i.e., arthrokinematics) of the tibiotalar and subtalar joints. Metal beads were implanted in the tibia, talus and calcaneus of two cadavers...
May 2015: Gait & Posture
V Cijo George, D R Naveen Kumar, P K Suresh, R Ashok Kumar
Annona muricata is a naturally occurring edible plant with wide array of therapeutic potentials. In India, it has a long history of traditional use in treating various ailments. The present investigation was carried out to characterize the phytochemicals present in the methanolic and aqueous leaf extracts of A. muricata, followed by validation of its radical scavenging and DNA protection activities. The extracts were also analyzed for its total phenolic contents and subjected to HPLC analysis to determine its active metabolites...
April 2015: Journal of Food Science and Technology
H Blasco, J Błaszczyński, J C Billaut, L Nadal-Desbarats, P F Pradat, D Devos, C Moreau, C R Andres, P Emond, P Corcia, R Słowiński
BACKGROUND: Metabolomics is an emerging field that includes ascertaining a metabolic profile from a combination of small molecules, and which has health applications. Metabolomic methods are currently applied to discover diagnostic biomarkers and to identify pathophysiological pathways involved in pathology. However, metabolomic data are complex and are usually analyzed by statistical methods. Although the methods have been widely described, most have not been either standardized or validated...
February 2015: Journal of Biomedical Informatics
Antonio Boggia, Lucia Rocchi, Luisa Paolotti, Francesco Musotti, Salvatore Greco
Rural Development is a priority in Europe and it is supported by specific, financial programmes. At the same time, sustainability is the key word for the European Union to construct programmes and policies for all human activities. However, measuring sustainability of rural areas is not easy, due to their particular features. The improvement of knowledge on sustainability in rural areas is important to build long term policies and strategies for those territories. The objective of this study is the development of a decision support system based on the Dominance-based Rough Set Approach (DRSA), to assess the level of Rural Sustainable Development in specific areas...
November 1, 2014: Journal of Environmental Management
Radosław Jarząbek, Paweł Bugajski, Krzysztof Greberski, Jerzy Błaszczyński, Barbara Słowińska-Jarząbek, Ryszard Kalawski
BACKGROUND: Intensive care unit (ICU) readmission after cardiac surgery is believed to be associated with higher in-hospital mortality and may predict poor outcomes. ICU readmissions use resources and increase treatment costs. AIM: To determine reasons for readmission to ICU, evaluate outcomes in these patients, and identify factors predisposing to the need for readmission to ICU. METHODS: We retrospectively investigated a total of 2076 consecutive adult patients who underwent either isolated coronary artery bypass grafting or a valve procedure or combination of both and were discharged from our ICU between January 2008 and December 2010...
2014: Kardiologia Polska
Didem Aksoy Körpe, Özlem Darcansoy İşerı, Feride Iffet Sahin, Evren Cabi, Mehmet Haberal
The aim of this study was to comparatively evaluate antibacterial activities of methanol (MetOH) and aqueous (dw) leaf (L), root (R) and seed (S) extracts of Urtica dioica L. (Ud; stinging nettle) and Urtica pilulifera L. (Up; Roman nettle) on both food- and plant-borne pathogens, with total phenolic contents and DPPH radical scavenging activities (DRSA). MetOH extracts of leaves and roots of U. dioica had the highest DRSA. Extracts with high antibacterial activity were in the order Up-LMetOH (13/16) > Ud-SMetOH (11/16) > Up-SMetOH (9/16)...
May 2013: International Journal of Food Sciences and Nutrition
L A González, K S Schwartzkopf-Genswein, M Bryan, R Silasi, F Brown
The objective of the present work was to study space allowance in cattle during commercial long haul transport (≥400 km; n = 6,152 journeys). Surveys, delivered to livestock transport carriers, gathered information on the number, BW, and distribution of cattle by trailer compartment as well as the characteristics of the transport vehicles used. Space allowance (SA; m(2)/animal), allometric coefficient (k = SA / BW(0.6667)), and the percentage of deviation from recommended SA (DRSA; %) in the Canadian Codes of Practice were calculated for each compartment of the trailers...
October 2012: Journal of Animal Science
Kenji Hayashida, Makoto Tanaka, Kota Koizumi, Masaaki Kakiuchi
PURPOSE: The purpose of this study was to examine magnetic resonance imaging (MRI) findings and elucidate retear pattern and its characteristics after surgical repair of the rotator cuff using an arthroscopic double-row suture anchor (DRSA) method. METHODS: Forty-seven patients with complete rotator cuff tears treated by the DRSA method under arthroscopy whose repair condition was assessed by MRI approximately 12 months after the procedure were included in the study...
April 2012: Arthroscopy: the Journal of Arthroscopic & related Surgery
Francisco M Gomez-Soto, José L Puerto, José L Andrey, Francisco J Fernandez, Miguel A Escobar, Antonio A Garcia-Egido, Sotero P Romero, José A Bernal, F Gomez
BACKGROUND AND OBJECTIVE: To evaluate if consultation between specialists in Internal Medicine and family doctors (CIMFD) improves the clinical management and prognosis of patients with heart failure (HF). METHODS: HASH(0x43821f0) DESIGN: prospective case-control study (5 years of follow-up). SETTING: community-based sample within the area of a university teaching hospital. SUBJECTS: 1857 patients (> or = 14 years) diagnosed for the first time with HF (1stDxHF), in the CIMFD...
November 2008: European Journal of Internal Medicine
G Papaioannou, G Nianios, C Mitrogiannis, D Fyhrie, S Tashman, K H Yang
Little is known about in vivo menisci loads and displacements in the knee during strenuous activities. A new method that combines high-speed kinematics measured with biplane dynamic Roentgen stereogrammetric analysis (DRSA) and a subject-specific finite element (FE) model for studying in vivo meniscal behavior is presented here. Further model calibration in a very controlled uniaxial low and high-rate compression loading condition is presented by comparing the model behavior against the measured high-accuracy menisci DRSA kinematics and direct tibio-femoral pressure measurement from a K-scan sensor...
August 28, 2008: Journal of Biomechanics
Tomoko Matsumoto, Toshiyuki Tsurumoto, Hideo Baba, Makoto Osaki, Hiroshi Enomoto, Akihiko Yonekura, Hiroyuki Shindo, Toshio Miyata
Advanced glycation endproducts (AGEs) are the products of non-enzymatic glycation and oxidation of proteins and lipids. Low-turnover tissues such as articular cartilage seem to be susceptible to the accumulation of AGEs, which might lead to cartilage degradation. Recently, a non-invasive method for measuring skin AGE accumulation was developed by using the Autofluorescence Reader (AFR). To examine the usefulness of measuring skin AGE in patients with bone and joint diseases, we examined autofluorescence (AF) levels in skin of patients with osteoarthritis (OA), rheumatoid arthritis (RA), and dialysis-related spondyloarthropathy (DRSA)...
December 2007: Rheumatology International
Steven W Meier, Jeffrey D Meier
There is a high rate of recurrent and residual tears after rotator cuff repair surgery. Recent cadaveric studies have provided surgeons with new knowledge about the anatomy of the supraspinatus tendon insertion. Traditional repair techniques fail to reproduce the area of the supraspinatus insertion, or footprint, on the greater tuberosity anatomically. Double-row suture anchor (DRSA) fixation is a new technique that has been developed to restore the supraspinatus footprint better. In this study, 3-dimensional mapping was used to determine the area of the footprint recreated with 3 different repair methods: a transosseous simple suture technique, fixation with a single row of suture anchors, and DRSA fixation...
November 2006: Journal of Shoulder and Elbow Surgery
Steven W Meier, Jeffrey D Meier
PURPOSE: The purpose of this study was to compare the initial mechanical strength of 3 rotator cuff repair techniques. METHODS: A total of 30 fresh-frozen cadaveric shoulders were prepared, and full-thickness supraspinatus tears were created. Specimens were randomized and placed into 3 groups: (1) transosseous suture technique (group I: TOS, n = 10, 6F/4M), (2) single-row suture anchor fixation (group II: SRSA, n = 10, 6F/4M), and (3) double-row suture anchor fixation (group III: DRSA, n = 10, 6F/4M)...
November 2006: Arthroscopy: the Journal of Arthroscopic & related Surgery
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