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Hypertension And Antihypertensives

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https://www.readbyqxmd.com/read/30546052/physician-pharmacist-collaborative-practice-and-telehealth-may-transform-hypertension-management
#1
REVIEW
Stefano Omboni, Mauro Tenti, Claudio Coronetti
Community pharmacists play a crucial role in hypertension management and their intervention, mainly including education, medication monitoring, and reviewing, blood pressure (BP) measurement and cardiovascular risk factors tracking, have proved to enhance BP control and adherence to antihypertensive treatment. A multidisciplinary collaborative approach with the referring physician and a patient-centered model of care have been proved to be particularly effective for improving control of hypertension and promoting patients' health...
December 13, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/30544795/-spirulina-maxima-decreases-endothelial-damage-and-oxidative-stress-indicators-in-patients-with-systemic-arterial-hypertension-results-from-exploratory-controlled-clinical-trial
#2
Jesús Martínez-Sámano, Adriana Torres-Montes de Oca, Oscar Ivan Luqueño-Bocardo, Patricia V Torres-Durán, Marco A Juárez-Oropeza
(1) Background: Spirulina ( Arthrospira ) maxima has shown beneficial effects such as being anti-dyslipidemic, antiviral, antioxidant and antihypertensive. However, there are few and limited clinical studies. (2) Methods: a prospective, randomized, parallel pilot study of 4.5 g administration of Spirulina maxima or placebo for 12 weeks in 16 patients with systemic arterial hypertension (SAH) undergoing treatment with angiotensin-converting enzyme (ACE) inhibitors was performed to assess the effects on endothelial damage and oxidative stress indicators...
December 8, 2018: Marine Drugs
https://www.readbyqxmd.com/read/30543913/vasorelaxant-and-chemical-fingerprint-studies-of-citrus-reticulatae-pericarpium-extracts
#3
Chu Shan Tan, Yean Chun Loh, Yung Sing Ch'ng, Chiew Hoong Ng, Zhao Qin Yeap, Mariam Ahmad, Mohd Zaini Asmawi, Mun Fei Yam
ETHNOPHARMACOLOGICAL RELEVANCE: Citrus reticulatae Pericarpium (Chen pi) was widely used as an important ingredient in the prescription of TCM to treat phlegm fluid retention type hypertension. Since Chen pi is involved in treatment as antihypertensive TCM formula, we have reasonable expectation in believing that it might possess vasorelaxant activity. AIM OF THE STUDY: This study is designed to investigate the vasorelaxant effect of Chen pi and to study its pharmacology effects...
December 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30543092/losartan-inhibits-egfr-transactivation-in-vascular-smooth-muscle-cells
#4
Mustafa Kırça, Akın Yeşilkaya
Background/aim: Angiotensin II (Ang II)-induced molecular signaling pathways play a significant role in the progression of cardiovascular diseases, including hypertension and atherosclerosis. In addition to the well-known effects of Ang II, it may activate epidermal growth factor receptor (EGFR) in a process known as transactivation, which contributes to vascular pathologies. The aim of this study was to determine whether losartan could reduce EGFR transactivation induced by Ang II. Additionally, we evaluated the roles of heparin-binding epidermal-like growth factor (HB-EGF) and matrix metalloproteinases (MMPs) in Ang II-induced EGFR transactivation...
December 12, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30542527/immunosuppression-associated-posterior-reversible-encephalopathy-syndrome-in-an-acute-leukemia-case
#5
Umit Y Malkan, Gursel Gunes, Haluk Demiroglu, Hakan Goker
Posterior reversible encephalopathy syndrome (PRES) was described in 1996. Herein, we aimed to report an immunosuppression- related PRES case. A 34-year-old woman was diagnosed as t-cell acute lymphoblastic leukemia and allogeneic hematopoietic stem cell transplantation (HSCT) was performed. Cyclosporine was given for GVHD prophylaxis in addition to the other routine medications of HSCT. She was hospitalized for acute renal failure and due to the possible contribution of acute renal failure cyclosporine was stopped...
November 6, 2018: Hematology Reports
https://www.readbyqxmd.com/read/30542082/cornell-product-in-an-electrocardiogram-is-related-to-reduced-lv-regional-wall-motion
#6
Joji Ishikawa, Yuko Yamanaka, Shintaro Watanabe, Ayumi Toba, Kazumasa Harada
Electrocardiographic left ventricular hypertrophy (LVH) diagnosed by Cornell product and the Sokolow-Lyon voltage are associated with anatomical LVH; therefore, we investigated whether Cornell product and the Sokolow-Lyon voltage were associated with echocardiographic regional wall motion (measured by 2D-strain imaging). We reviewed data on 288 consecutive hypertensive patients who underwent both echocardiography and electrocardiography. Electrocardiographic LVH was calculated as follows: Cornell voltage, S in lead V3 + R in lead aVL; Cornell product, Cornell voltage (+0...
December 12, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30540406/poor-oral-health-and-blood-pressure-control-among-us-hypertensive-adults-results-from-the-national-health-and-nutrition-examination-survey-2009-to-2014
#7
Davide Pietropaoli, Rita Del Pinto, Claudio Ferri, Jackson T. Wright, Mario Giannoni, Eleonora Ortu, Annalisa Monaco
Periodontal disease is a chronic inflammatory disorder of the tissues surrounding the teeth, with evidence of systemic effects. Some studies showed the benefit of periodontal therapy on blood pressure (BP), but the impact of periodontitis on BP control is unknown. We retrospectively analyzed cross-sectional, nationally representative data from treated hypertensive adults aged ≥30 years with and without periodontitis. BP was examined as both continuous (mm Hg) and categorical (treatment goal achievement status according to guidelines: at goal and above goal) variable according to the presence or absence of periodontitis and its clinical parameters (probing depth, clinical attachment loss, and disease severity [mild, moderate, and severe])...
October 22, 2018: Hypertension
https://www.readbyqxmd.com/read/30535368/reconsidering-the-cut-off-diastolic-blood-pressure-for-predicting-cardiovascular-events-a-nationwide-population-based-study-from-korea
#8
You-Jung Choi, Sun-Hwa Kim, Si-Hyuck Kang, Chang-Hwan Yoon, Hae-Young Lee, Tae-Jin Youn, In-Ho Chae, Cheol-Ho Kim
Aims: It is unclear whether a J-curve association exists in cardiovascular risk prediction and how independently systolic and diastolic blood pressure (BP) predict cardiovascular outcomes. This study evaluated the association of systolic and diastolic BP with major cardiovascular events to clarify these issues. Methods and results: Antihypertensive medication-naïve subjects with available BP measurements and no history of cardiovascular events were extracted from the National Health Insurance Services Health Screening Cohort...
December 6, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30535341/non-linear-relationship-between-blood-pressure-and-glaucoma-in-us-adults
#9
Hyojin Kim, BongKyoo Choi
BACKGROUND: Previous studies have reported that vascular disease is associated with glaucoma. However, the relationship between blood pressure (BP) and glaucoma has been inconsistent. We investigated whether there is a non-linear association between BP and glaucoma in an adult population of the United States. METHODS: From the 2005-2008 National Health and Nutrition Examination Surveys (NHANES) data, 4,137 participants aged 40 and older were chosen. BP was assessed based on a standard protocol...
December 8, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/30531843/effects-of-hypertension-and-antihypertensive-treatments-on-sulfatide-levels-in-serum-and-its-metabolism
#10
Ran Guo, Xiao Hu, Yosuke Yamada, Makoto Harada, Takero Nakajima, Toshihide Kashihara, Mitsuhiko Yamada, Toshifumi Aoyama, Yuji Kamijo
Serum sulfatides are critical glycosphingolipids present in lipoproteins that work as modulators of thrombosis and hemostasis. Decreased serum sulfatide levels are suggested by our previous work to be related to cardiovascular disease (CVD). Hypertension, known to be an important risk factor for CVD, may affect serum sulfatide levels. However, how hypertension affects serum sulfatides directly and mechanistically is unknown. To elucidate these possible mechanisms, we investigated changes in serum sulfatide levels and their metabolism using an established experimental model of hypertension that uses continuous infusion of angiotensin II (AngII) into mice...
December 10, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30530462/a-novel-just-in-time-contextual-mobile-app-intervention-to-reduce-sodium-intake-in-hypertension-protocol-and-rationale-for-a-randomized-controlled-trial-lowsalt4life-trial
#11
Michael P Dorsch, Lawrence C An, Scott L Hummel
BACKGROUND: High sodium intake is a significant public health problem in the United States. Interventions that lower sodium intake can decrease blood pressure and improve cardiovascular outcomes. Restaurants and grocery stores are prime targets for intervention with about 77% of all sodium intake in the average US diet coming from processed and restaurant foods. OBJECTIVE: This study proposes that a mobile app intervention that promotes low-sodium alternatives at grocery stores and restaurants will reduce dietary intake of sodium and improve confidence following a low-sodium diet in hypertension...
December 7, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/30529389/individualized-dosing-of-axitinib-based-on-first-dose-area-under-the-concentration-time-curve-for-metastatic-renal-cell-carcinoma
#12
Yuji Miura, Chiyo K Imamura, Keita Uchino, Takeshi Kishida, Nobuaki Matsubara, Toshiaki Shinojima, Keiichi Kondo, Fumiya Hongo, Kenichi Yoshimura, Yusuke Tanigawara, Toshimi Takano
BACKGROUND: Previous studies have revealed that higher exposure of axitinib leads to better prognosis in metastatic renal-cell carcinoma. We thus assessed individualized dosing of axitinib on the basis of the first-dose area under the concentration-time curve from 0 to 12 hours (AUC0-12 ) for sunitinib-pretreated metastatic renal-cell carcinoma patients. PATIENTS AND METHODS: In this prospective single-arm trial, the starting dose of axitinib was 5 mg twice daily...
September 29, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/30527153/hypotensive-effect-of-heated-water-based-exercise-persists-after-12-week-cessation-of-training-in-patients-with-resistant-hypertension
#13
Guilherme Veiga Guimãraes, Miguel Morita Fernandes-Silva, Luciano Ferreira Drager, Lais Galvani de Barros Cruz, Rafael Ertner Castro, Emmanuel Gomes Ciolac, Edimar Alcides Bocchi
BACKGROUND: Heated water-based exercise (HEx) promotes a marked reduction of blood pressure (BP), but it is not entirely clear whether its effects on BP persist after cessation of HEx. METHODS: We analyzed the effects of cessation of HEx on 24-hour ambulatory BP monitoring (ABPM) in patients with resistant hypertension (RH). Thirty-two patients (aged 53 ± 6 years) with RH (4 to 6 antihypertensive drugs) were randomly assigned to HEx (n = 16) or control (n = 16) groups...
December 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/30527119/timely-treatment-of-severe-maternal-hypertension-and-reduction-in-severe-maternal-morbidity
#14
Megha Gupta, Naomi Greene, Sarah J Kilpatrick
OBJECTIVE: To determine if timely treatment within 60 min of confirmed diagnosis of severe maternal hypertension with antihypertensive medications was associated with reduction in severe maternal morbidity. STUDY DESIGN: Medical records of women with severe hypertension (at least two severe blood pressures, systolic ≥160 mmHg and/or diastolic ≥110 mmHg, within 60 min) were accessed for timing of severe blood pressures, timing of treatment, and blood pressure response to treatment...
October 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/30527112/severe-hypertension-preeclampsia-and-small-for-gestational-age-in-women-with-chronic-hypertension-diagnosed-before-and-during-pregnancy
#15
Diane Nzelu, Dan Dumitrascu-Biris, Polly Kay, Kypros H Nicolaides, Nikos A Kametas
OBJECTIVES: To compare rates of severe hypertension (SH), preeclampsia (PE) birth of small for gestational age (SGA) neonates between women with chronic hypertension (CH) diagnosed during the first trimester of pregnancy and those with pre-pregnancy CH. STUDY DESIGN: Prospective cohort study of women with CH and singleton pregnancies referred to an Antenatal Hypertension Clinic at 8-14 weeks' gestation. At presentation the patients were subdivided into four groups based on blood pressure (BP) control...
October 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/30527096/association-of-antepartum-blood-pressure-levels-and-angiogenic-profile-among-women-with-chronic-hypertension
#16
Ruby Minhas, Danielle Young, Rabab Naseem, Ariel Mueller, Sireesha Chinthala, Joana Lopes Perdigao, Kiang-Teck J Yeo, Siaw Li Chan, Avery Tung, Julia Bregand White, Sajid Shahul, Sarosh Rana
BACKGROUND: Angiogenic factors have been implicated in the pathogenesis of preeclampsia. This pilot study explored the association between antenatal blood pressure levels and angiogenic biomarkers (sFlt1 and PlGF) among women with chronic hypertension (cHTN). METHODS: Blood samples were collected from women with cHTN (with/without superimposed preeclampsia) within 96 h prior to delivery. Subjects were stratified by mean outpatient BP as controlled (cBP < 140/90) or uncontrolled (uBP ≥ 140/90)...
October 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/30525343/poor-oral-health-and-blood-pressure-control-among-us-hypertensive-adults-results-from-the-national-health-and-nutrition-examination-survey-2009-to-2014
#17
Davide Pietropaoli, Rita Del Pinto, Claudio Ferri, Jackson T. Wright, Mario Giannoni, Eleonora Ortu, Annalisa Monaco
Periodontal disease is a chronic inflammatory disorder of the tissues surrounding the teeth, with evidence of systemic effects. Some studies showed the benefit of periodontal therapy on blood pressure (BP), but the impact of periodontitis on BP control is unknown. We retrospectively analyzed cross-sectional, nationally representative data from treated hypertensive adults aged ≥30 years with and without periodontitis. BP was examined as both continuous (mm Hg) and categorical (treatment goal achievement status according to guidelines: at goal and above goal) variable according to the presence or absence of periodontitis and its clinical parameters (probing depth, clinical attachment loss, and disease severity [mild, moderate, and severe])...
October 22, 2018: Hypertension
https://www.readbyqxmd.com/read/30525279/morning-surge-in-blood-pressure-and-blood-pressure-variability-in-asia-evidence-and-statement-from-the-hope-asia-network
#18
REVIEW
Guru P Sogunuru, Kazuomi Kario, Jinho Shin, Chen-Huan Chen, Peera Buranakitjaroen, Yook C Chia, Romeo Divinagracia, Jennifer Nailes, Sungha Park, Saulat Siddique, Jorge Sison, Arieska A Soenarta, Jam C Tay, Yuda Turana, Yuqing Zhang, Satoshi Hoshide, Ji-Guang Wang
Hypertension is a major risk factor for cardiovascular and cerebrovascular diseases. To effectively prevent end-organ damage, maintain vascular integrity and reduce morbidity and mortality, it is essential to decrease and adequately control blood pressure (BP) throughout each 24-hour period. Exaggerated early morning BP surge (EMBS) is one component of BP variability (BPV), and has been associated with an increased risk of stroke and cardiovascular events, independently of 24-hour average BP. BPV includes circadian, short-term and long-term components, and can best be documented using out-of-office techniques such as ambulatory and/or home BP monitoring...
December 7, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/30525273/the-impact-of-apelin-and-relaxin-plasma-levels-in-masked-hypertension-and-white-coat-hypertension
#19
Elias Sanidas, Kostas Tsakalis, Dimitrios P Papadopoulos, Kanella Zerva, Maria Velliou, Despoina Perrea, Marina Mantzourani, Dimitrios Iliopoulos, John Barbetseas
Masked hypertension (HTN) and white coat hypertension represent two reverse forms of clinical HTN with questionable prognostic significance. Recent evidence supports that low apelin and relaxin plasma levels contribute to vascular damage accelerating atherogenesis and predisposing to HTN and cardiovascular (CV) events. The aim of this study was to compare apelin and relaxin plasma levels between patients with masked hypertension (MH) and those with white coat HTN (WCH). Overall, 130 patients not receiving antihypertensive therapy were studied...
December 7, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/30525180/resistant-and-refractory-hypertension-two-sides-of-the-same-disease
#20
Elizabeth Silaid Muxfeldt, Bernardo Chedier, Cibele Isaac Saad Rodrigues
Refractory hypertension (RfH) is an extreme phenotype of resistant hypertension (RH), being considered an uncontrolled blood pressure besides the use of 5 or more antihypertensive medications, including a long-acting thiazide diuretic and a mineralocorticoid antagonist. RH is common, with 10-20% of the general hypertensives, and its associated with renin angiotensin aldosterone system hyperactivity and excess fluid retention. RfH comprises 5-8% of the RH and seems to be influenced by increased sympathetic activity...
December 6, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
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