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https://www.readbyqxmd.com/read/30341504/treatment-patterns-by-egfr-mutation-status-in-non-small-cell-lung-cancer-patients-in-the-usa-a-retrospective-database-analysis
#1
Kathleen M Aguilar, Katherine B Winfree, Catherine E Muehlenbein, Yajun Emily Zhu, Thomas Wilson, Stewart Wetmore, Eric S Nadler
INTRODUCTION: Targeted therapies, including tyrosine kinase inhibitors (TKIs) that target the sensitizing epidermal growth factor receptor (EGFR) gene are recommended for patients with non-small cell lung cancer (NSCLC). Most patients with NSCLC who test positive for the EGFR mutation and receive TKIs develop resistance to these drugs. Questions remain regarding which treatment sequence is optimal for patients with EGFR-mutant NSCLC, and few studies have evaluated patterns of TKI treatment use in NSCLC, irrespective of EGFR mutation status, in a real-world setting...
October 19, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/30341448/-correction-to-drugs-for-intravenous-induction-of-anesthesia-ketamine-midazolam-and-synopsis-of-current-hypnotics
#2
E Halbeck, C Dumps, D Bolkenius
No abstract text is available yet for this article.
October 19, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/30338261/comparing-the-efficacy-of-iv-ibuprofen-and-ketorolac-in-the-management-of-postoperative-pain-following-arthroscopic-knee-surgery-a-randomized-double-blind-active-comparator-pilot-study
#3
Alberto A Uribe, Fernando L Arbona, David C Flanigan, Christopher C Kaeding, Marilly Palettas, Sergio D Bergese
Introduction: Acute postoperative pain following knee arthroscopy is common in orthopedic surgeries. Managing pain postoperatively combines usage of opioids and non-steroidal anti-inflammatory drugs. The aim of this clinical study was to assess the efficacy of two different analgesic treatment regimens: intravenous (IV) ibuprofen and IV ketorolac for the treatment of postoperative pain pertaining to arthroscopic knee surgery. Methods: This was a single center, randomized, double-blind, parallel, active comparator clinical pilot study...
2018: Frontiers in Surgery
https://www.readbyqxmd.com/read/30337746/-effect-of-dexmedetomidine-on-supraclavicular-brachial-plexus-block-a-randomized-double-blind-prospective-study
#4
Y Li, H Wang, Y Deng, Y Yao, M Li
OBJECTIVE: To evaluate the effect of dexmedetomidine combined with ropivacaine on brachial plexus block in patients scheduled for elective shoulder arthroscopy. METHODS: Ninety patients with American Society of Anesthesiologists (ASA) I or II, scheduled for elective shoulder arthroscopy, were randomly divided into three groups. In group R (n=30), the patients were given 10 mL of 0.375% ropivacaine in branchial plexus block (interscalene approach guided by ultrasound), in group D1 (n=30), the patients were given 10 mL of 0...
October 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/30337273/safety-tolerability-and-preliminary-efficacy-of-an-igf-1-mimetic-in-patients-with-spinal-and-bulbar-muscular-atrophy-a-randomised-placebo-controlled-trial
#5
Christopher Grunseich, Ram Miller, Therese Swan, David J Glass, Mohamed El Mouelhi, Mara Fornaro, Olivier Petricoul, Igor Vostiar, Ronenn Roubenoff, Matthew N Meriggioli, Angela Kokkinis, Robert D Guber, Maher S Budron, John Vissing, Gianni Soraru, Tahseen Mozaffar, Albert Ludolph, John T Kissel, Kenneth H Fischbeck
BACKGROUND: Spinal and bulbar muscular atrophy is an X-linked neuromuscular disease caused by CAG repeat expansion in the androgen receptor gene. Patients with this disease have low concentrations of insulin-like growth factor-1 (IGF-1), and studies of overexpression and administration of IGF-1 showed benefit in a transgenic model; thus the IGF-1 pathway presents as a potential treatment target. We assessed safety, tolerability, and preliminary efficacy of BVS857, an IGF-1 mimetic, in patients with spinal and bulbar muscular atrophy...
October 15, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30336952/corrigendum-to-physical-compatibility-of-meropenem-and-vaborbactam-with-select-intravenous-drugs-during-simulated-y-site-administration-clinical-therapeutics-40-2018-261-269
#6
James M Kidd, Lindsay M Avery, Tomefa E Asempa, David P Nicolau, Joseph L Kuti
No abstract text is available yet for this article.
October 16, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/30336720/lacosamide-pharmacokinetics-in-a-critically-ill-patient-during-continuous-renal-replacement-therapy
#7
Patrick M Wieruszewski, Arnaldo Lopez-Ruiz, Robert C Albright, Jennifer E Fugate, Erin Frazee Barreto
The objective of this study is to describe the pharmacokinetics of lacosamide in a critically ill adult during continuous venovenous hemofiltration (CVVH). A 78-year-old male developed sepsis and acute kidney injury following cardiac surgery. He was initially treated with intermittent hemodialysis but developed nonconvulsive status epilepticus at the end of the first session and was subsequently initiated on CVVH. In addition to lorazepam boluses, levetiracetam, and midazolam infusion, he was loaded with lacosamide 400 mg intravenously and started on 200 mg intravenously twice daily as maintenance therapy...
October 18, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30334956/comparison-of-the-response-of-frequently-relapsing-steroid-dependent-minimal-change-nephrotic-syndrome-to-rituximab-therapy-between-childhood-onset-and-adult-onset-disease
#8
Yuko Iwabuchi, Yoei Miyabe, Shiho Makabe, Marie Nakano, Shun Manabe, Kazunori Karasawa, Takahito Moriyama, Kosaku Nitta
Rituximab has been approved in Japan for the treatment of intractable nephrotic syndrome, but in cases of childhood-onset disease only; its efficacy and safety in adult-onset disease has yet to be established. This study was undertaken to evaluate the efficacy of rituximab and adverse effects in patients with adult-onset minimal change nephrotic syndrome (MCNS).The study involved 32 childhood-onset cases (mean age at onset: 8.6 years) and 19 adult-onset cases (mean age at onset: 30.6 years) of frequently relapsing steroid-dependent MCNS, all of whom received intravenous rituximab drip infusion (375 mg/m body surface area per dose) at 4 time points at 6-month intervals...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30334626/the-actual-management-of-hepatitis-b-and-hepatitis-c-in-children
#9
Irini D Batsis, Paul Wasuwanich, Wikrom W Karnsakul
In the present paper, we review the increased disease burden of Hepatitis B (HBV) and Hepatitis C (HCV) infection that is recognized worldwide; especially in children when the most common mode of transmission is vertically from infected mothers. In children with HBV and HCV infection, spontaneous clearance of the virus in the first years of life is not common, in contrast with adults, but these patients often stay asymptomatic until early adulthood, when disease has progressed to chronic hepatitis with increased risk of cirrhosis and its complication, and hepatocellular carcinoma...
October 18, 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/30333366/negative-lusitropic-property-of-nifekalant-identified-using-ventricular-pressure-volume-loop-analyses-in-anesthetized-monkeys
#10
Tomomichi Ishizaka, Yu Yoshimatsu, Yu Maeda, Katsuyoshi Chiba, Kazuhiko Mori
The present study was conducted to clarify multiple cardiohemodynamic and electrophysiological properties including inotropic/lusitropic effects of nifekalant, a class III antiarrhythmic drug, in an isoflurane-anesthetized monkey. Nifekalant was administered intravenously at the therapeutic dose of 0.3 mg/kg over 10 minutes to male cynomolgus monkeys (n=4), followed by higher dose of 1 (n=3) or 3 mg/kg (n=1) that was limited due to arrythmogenicity. Left ventricular (LV) pressure-volume (PV) analysis revealed that the 0...
October 17, 2018: Experimental Animals
https://www.readbyqxmd.com/read/30332946/enzymatic-hydrolysis-of-hyaluronic-layer-before-drug-dosing
#11
Anna Trusek-Holownia, Anita Niesobska, Damian Semba
Polymeric drug delivery system, allowing the controlled long-term drug release, is a good alternative to the standard way (oral or intravenous) of pharmaceuticals' administration. The most widespread drug release strategy is based on the drug molecules diffusion: first inside the carrier, then through the external layers of carrier and then, outside the carrier, to the cells surrounding. The proposed type of the local therapy is a particularly proper approach in treatment of cancer diseases, at which the drugs are highly toxic...
October 17, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30328645/empagliflozin-directly-improves-diastolic-function-in-human-heart-failure
#12
Steffen Pabel, Stefan Wagner, Hannah Bollenberg, Philipp Bengel, Árpád Kovács, Christian Schach, Petros Tirilomis, Julian Mustroph, André Renner, Jan Gummert, Thomas Fischer, Sophie Van Linthout, Carsten Tschöpe, Katrin Streckfuss-Bömeke, Gerd Hasenfuss, Lars S Maier, Nazha Hamdani, Samuel Sossalla
AIMS: Empagliflozin, a clinically used oral antidiabetic drug that inhibits the sodium-dependent glucose co-transporter 2, has recently been evaluated for its cardiovascular safety. Surprisingly, empagliflozin reduced mortality and hospitalization for heart failure (HF) compared to placebo. However, the underlying mechanisms remain unclear. Therefore, our study aims to investigate whether empagliflozin may cause direct pleiotropic effects on the myocardium. METHODS AND RESULTS: In order to assess possible direct myocardial effects of empagliflozin, we performed contractility experiments with in toto-isolated human systolic end-stage HF ventricular trabeculae...
October 17, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/30328074/acinetobacter-baumannii-meningitis-in-children-a-case-series-and-literature-review
#13
Jiying Xiao, Chenmei Zhang, Sheng Ye
INTRODUCTION: The incidence of Acinetobacter baumannii meningitis, which typically occurs after neurosurgery, has increased in recent years. Pediatric Acinetobacter baumannii meningitis due to the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains has important clinical significance. METHODOLOGY: We retrospectively reviewed the clinical course and outcome of nine cases of meningitis due to Acinetobacter baumannii in children and reviewed the relevant literature...
October 16, 2018: Infection
https://www.readbyqxmd.com/read/30327982/a-preliminary-study-on-plasma-concentration-achieved-following-intrapterygomandibular-space-injection-of-dexamethasone-as-a-route-of-drug-delivery-with-lignocaine-inferior-alveolar-nerve-block-correlation-of-clinical-effects
#14
Darpan Bhargava, Rajkumar Ahirwal, Ganesh Koneru, Balaji R Srikanth, Sivakumar Beena
PURPOSE: To determine the quantity of dexamethasone plasma concentration achieved following intrapterygomandibular space injection of dexamethasone when co-administered with inferior alveolar nerve block correlating with the clinical effects in the postoperative phase. OBJECTIVE: A preliminary prospective study to evaluate the dexamethasone plasma concentration achieved following intrapterygomandibular space injection of dexamethasone with 2% lignocaine inferior alveolar nerve block to achieve hemi-mandibular anesthesia for minor oral surgical procedures and derive clinical correlations...
October 16, 2018: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/30327544/multiple-circulating-saponins-from-intravenous-shenmai-inhibit-oatp1bs-in-vitro-potential-joint-precipitants-of-drug-interactions
#15
Olajide E Olaleye, Wei Niu, Fei-Fei Du, Feng-Qing Wang, Fang Xu, Salisa Pintusophon, Jun-Lan Lu, Jun-Ling Yang, Chuan Li
ShenMai, an intravenous injection prepared from steamed Panax ginseng roots (Hongshen) and Ophiopogon japonicus roots (Maidong), is used as an add-on therapy for coronary artery disease and cancer; saponins are its bioactive constituents. Since many saponins inhibit human organic anion-transporting polypeptides (OATP)1B, this investigation determined the inhibition potencies of circulating ShenMai saponins on the transporters and the joint potential of these compounds for ShenMai-drug interaction. Circulating saponins and their pharmacokinetics were characterized in rats receiving a 30-min infusion of ShenMai at 10 mL/kg...
October 16, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/30324285/physicochemical-characterization-of-ferric-pyrophosphate-citrate
#16
Ajay Gupta, Raymond Pratt, Bhoopesh Mishra
Iron deficiency is a significant health problem across the world. While many patients benefit from oral iron supplements, some, including those on hemodialysis require intravenous iron therapy to maintain adequate iron levels. Until recently, all iron compounds suitable for parenteral administration were colloidal iron-carbohydrate conjugates that require uptake and processing by macrophages. These compounds are associated with variable risk of anaphylaxis, oxidative stress, and inflammation, depending on their physicochemical characteristics...
October 15, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30324277/clinical-pharmacokinetics-and-pharmacodynamics-of-delafloxacin
#17
Jennifer Shiu, Grace Ting, Tony Kl Kiang
Delafloxacin has recently received approval by the US Food and Drug Administration for the treatment of acute bacterial skin and skin structure infections. This article provides a balanced and comprehensive systematic critique of the literature in order to provide an up-to-date summary of its clinical pharmacology. Oral delafloxacin is rapidly absorbed and exhibits comparable exposure characteristics (300 mg intravenous versus 450 mg oral) between the two formulations, allowing easy transition from intravenous to oral therapy...
October 15, 2018: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/30323622/evolving-role-of-neurokinin-1-receptor-antagonists-for-chemotherapy-induced-nausea-and-vomiting
#18
REVIEW
Rudolph M Navari, Lee S Schwartzberg
To examine pharmacologic and clinical characteristics of neurokinin 1 (NK1 )-receptor antagonists (RAs) for preventing chemotherapy-induced nausea and vomiting (CINV) following highly or moderately emetogenic chemotherapy, a literature search was performed for clinical studies in patients at risk of CINV with any approved NK1 RAs in the title or abstract: aprepitant (capsules or oral suspension), HTX019 (intravenous [IV] aprepitant), fosaprepitant (IV aprepitant prodrug), rolapitant (tablets or IV), and fixed-dose tablets combining netupitant or fosnetupi-tant (IV netupitant prodrug) with the 5-hydroxytryptamine type 3 (5HT3 ) RA palonosetron (oral or IV)...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/30323205/prefrontal-expectancy-and-reinforcement-driven-antidepressant-placebo-effects
#19
M Peciña, J Heffernan, J Wilson, J K Zubieta, A Y Dombrovski
Placebo responses in depression exemplify how expectancies and appraisals impact mood. Cognitive and neural mechanisms underlying these responses are still poorly understood, partly due to the difficulty of simulating antidepressant effects and manipulating mood experimentally. To address these challenges, we developed an acute antidepressant placebo experiment involving the intravenous administration of a "fast-acting antidepressant" and a trial-by-trial sham fMRI "neurofeedback" manipulation, purporting to reveal mood-relevant neural responses...
October 15, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/30322014/amphiphilic-polymeric-micelles-based-on-deoxycholic-acid-and-folic-acid-modified-chitosan-for-the-delivery-of-paclitaxel
#20
Liang Li, Na Liang, Danfeng Wang, Pengfei Yan, Yoshiaki Kawashima, Fude Cui, Shaoping Sun
The present investigation aimed to develop a tumor-targeting drug delivery system for paclitaxel (PTX). The hydrophobic deoxycholic acid (DA) and active targeting ligand folic acid (FA) were used to modify water-soluble chitosan (CS). As an amphiphilic polymer, the conjugate FA-CS-DA was synthesized and characterized by Proton nuclear magnetic resonance (¹H-NMR) and Fourier-transform infrared spectroscopy (FTIR) analysis. The degree of substitutions of DA and FA were calculated as 15.8% and 8.0%, respectively...
October 12, 2018: International Journal of Molecular Sciences
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