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Intravenous drug

Ivan Barbov, Jasmina Korunoska, Valentina Bonevska, Aleksandar Smokovski
No abstract text is available yet for this article.
July 1, 2018: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
Dmytro Butov, Yurii Feshchenko, Mykhailo Kuzhko, Mykola Gumeniuk, Tetiana Butova
The purpose of our study was to examine the efficacy and safety of intravenous chemotherapy during intensive treatment phase for patients with newly diagnosed pulmonary tuberculosis (pulmonary TB). MATERIALS AND METHODS: The study involved 92 patients with newly diagnosed pulmonary TB aged between 20 years and 68 years. All patient with newly diagnosed pulmonary TB and chemosensitive tuberculosis were enrolled in this study. The patients were allocated to two groups. The first (control) group of 46 patients received standard chemotherapy orally...
August 15, 2018: Advances in Respiratory Medicine
Devi Oktafiani, Ni Luh Ayu Megasari, Elsa Fitriana, Nasronudin, Maria Inge Lusida, Soetjipto
Background: Co-infection of human herpesvirus-8 (HHV-8) in HIV-positive people might cause Kaposi's sarcoma. Early detection of HHV-8 may prevent the onset of clinical manifestations. In Indonesia, detection of HHV-8 antigen in HIV-positive patients has yet to be reported. The intention of this research was to examine the presence of HHV-8 antigen in HIV-positive patients in East Java, Indonesia. Material and Methods: 103 serum samples were collected from HIV-positive patients in Surabaya and Tulungagung, East Java, Indonesia...
2018: African Journal of Infectious Diseases
Zhipeng Wang, Lei Xu, Han Wang, Zhenzhi Li, Lu Lu, Xiaojia Li, Qingyuan Zhang
The goal of this study was to assess the antitumor efficacy and safety of lobaplatin-based regimens as the second line of treatment in patients with metastatic breast cancer (MBC) resistant to anthracyclines and taxanes, compared with that of cisplatin-based regimens. During August 2012 to April 2015, 87 patients who received lobaplatin-based regimens or cisplatin-based regimens were included. Medical records of the patients noted that lobaplatin (30 mg/m2 ) or cisplatin (25 mg/m2 ), combined with another chemotherapeutic agent such as Gemcitabine (1000 mg/m2 ) or Vinorelbine (25 mg/m2 ), was intravenously given to the patients on a basis of twenty-one days as one treatment cycle...
July 2018: Saudi Journal of Biological Sciences
Michaël Philippe, Michael Neely, Teresa Rushing, Yves Bertrand, Nathalie Bleyzac, Sylvain Goutelle
Veno-occlusive disease (VOD) is a severe adverse reaction to busulfan-containing regimens used in the preparation of children for hematopoietic stem cell transplantation (HSCT). We conducted a retrospective analysis of data to examine determinants of VOD in children who received IV busulfan for HSCT conditioning. Busulfan PK parameters as well as various indices (maximal concentration-Cmax, area under the concentration-time curve-AUC) were estimated using a validated Bayesian approach. The influence of available PK, demographic, and clinical variables on the incidence of VOD was evaluated by using logistic regression and classification and regression tree (CART) analyses...
August 14, 2018: Bone Marrow Transplantation
Claudia Espinosa, Ravi Jhaveri, A Sidney Barritt
PURPOSE: Hepatitis C, a chronic disease with deadly consequences, is no longer predominantly a disease of older people. METHODS: A limited search was conducted of the relevant literature on 2 topics: (1) the impact of hepatitis C on infants exposed by vertical transmission; and (2) the impact of hepatitis C infection on infected children and adolescents. The findings were supplemented by the first-hand experience of the authors. FINDINGS: Young people, including women of childbearing age, infants, children, and adolescents, are being especially affected by hepatitis C infection secondary to the intravenous drug use and opioid epidemic...
August 11, 2018: Clinical Therapeutics
Dominique L Braun, Benjamin Hampel, Eileen Martin, Roger Kouyos, Katharina Kusejko, Christina Grube, Markus Flepp, Marcel Stöckle, Anna Conen, Charles Béguelin, Patrick Schmid, Julie Delaloye, Mathieu Rougemont, Enos Bernasconi, Andri Rauch, Huldrych F Günthard, Jürg Böni, Jan S Fehr
Background: The proportion of undiagnosed hepatitis C virus (HCV) infections in high-risk populations, such as human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) is unclear. Identification of potential HCV transmitters is important to reach World Health Organization HCV elimination targets. Methods: Between October 2015 and May 2016, we performed a systematic HCV RNA-based screening among HIV-infected MSM participating in the Swiss HIV Cohort Study (SHCS)...
August 13, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
S Omar Ali, Xiang Qing Yu, Gabriel J Robbie, Yuling Wu, Kathryn Shoemaker, Li Yu, Antonio DiGiandomenico, Ashley E Keller, Chuka Anude, Martha Hernandez-Illas, Terramika Bellamy, Judith Falloon, Filip Dubovsky, Hasan S Jafri
OBJECTIVES: MEDI3902 is a bivalent, bispecific human immunoglobulin G1κ monoclonal antibody that binds to both the Pseudomonas aeruginosa PcrV protein involved in host cell cytotoxicity and the Psl exopolysaccharide involved in P. aeruginosa colonization and tissue adherence. MEDI3902 is being developed for the prevention of nosocomial P. aeruginosa pneumonia in high-risk patients. METHODS: This phase 1 dose escalation study (NCT02255760) evaluated the safety, pharmacokinetics, anti-drug antibody (ADA) responses, and ex vivo anticytotoxicity and opsonophagocytic killing (OPK) activities of MEDI3902 after a single intravenous infusion in healthy adults 18- 60 years of age...
August 11, 2018: Clinical Microbiology and Infection
Satoshi Shibuta, Tomotaka Morita, Jun Kosaka
Anesthetic-induced neurotoxicity in the developing brain is a concern. This neurotoxicity is closely related to anesthetic exposure time, dose, and developmental stages. Using calcium imaging and morphological examinations in vitro, we sought to determine whether intravenous anesthetic-induced direct neurotoxicity varies according to different stages of the days in vitro (DIV) of neurons in primary culture. Cortical neurons from E17 Wistar rats were prepared. On DIV 3, 7, and 13, cells were exposed to the intravenous anesthetics thiopental sodium (TPS), midazolam (MDZ), or propofol (PPF), to investigate direct neurotoxicity using morphological experiments...
August 11, 2018: Neurotoxicology
Ofir Elalouf, Stephanie O Keeling, Zahi Touma
Systemic lupus erythematosus is a chronic autoimmune disease with various clinical manifestations, organ involvement and laboratory findings. The disease can involve any organ including skin, joints, kidneys, central and peripheral nervous system, cardiovascular system and more. Currently, the cornerstone of treatment includes antimalarial and immunosuppressive medications and glucocorticosteroids. Recently, great effort has been invested in finding more targeted drugs for achieving better control of the disease with less adverse events...
August 14, 2018: Immunotherapy
Xiaoyun Zheng, Xiaobo Huang, Jianmin Luo, Juan Li, Wei Li, Qifa Liu, Ting Niu, Xiaodong Wang, Jianfeng Zhou, Xi Zhang, Jianda Hu, Kaiyan Liu
INTRODUCTION: Invasive fungal infections (IFIs) are a significant health problem in immunocompromised patients, resulting in substantial morbidity, mortality, and healthcare costs. Micafungin is a broad-spectrum echinocandin with activity against Candida and Aspergillus spp. This was a multicenter, non-comparative, retrospective observational study that evaluated the effectiveness and tolerability of intravenously administered micafungin for treating IFIs caused by Candida and Aspergillus spp...
August 13, 2018: Advances in Therapy
Usha K Misra, Jayantee Kalita, Mritunjai Kumar
Importance: Tuberculous meningitis is associated with high frequency of cerebral salt wasting. There is a paucity of objective information regarding the best method of treatment of this condition. Objective: To evaluate the efficacy and safety of fludrocortisone in the treatment of cerebral salt wasting in patients with tuberculous meningitis. Design, Setting, and Participants: This is a single-center, open-label, randomized clinical trial conducted from October 2015 to April 2017 in India...
August 13, 2018: JAMA Neurology
Cancheng Liao, Danqiao Xu, Xiaohong Liu, Yuqi Fang, Jun Yi, Xiaofang Li, Bohong Guo
Background and aim: Iridium (Ir)-based complex is a potential antitumor ingredient, but its poor physicochemical properties such as hydrophobicity and low biocompatibility hamper further application. Liposome provides a potential delivery approach for improving the poor physicochemical property and reducing the side effects of antitumor drug. In this study, we aimed at incorporating Ir ([Ir(ppy)2 (BTCP)]PF6 ) into liposomes to enhance the biocompatibility and sustained release of Ir for intravenous administration and to elucidate the mechanism in A549 cells...
2018: International Journal of Nanomedicine
S Grau, C Denizci, N von Spreckelsen, R Goldbrunner, B W Böttiger, J Hinkelbein
Background and Aims: In contrast to propofol, volatile agents are often considered harmful to maintain anesthesia due to increasing brain volume and potential deleterious effects. Patients for cranioplasty, including patients with large bone defects, could be susceptible for intraoperative complications but have not properly been investigated so far. The aim of the present study was to evaluate brain swelling, intraoperative conditions, surgical course, and postoperative complication rates of propofol-based vs...
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
Yan Liu, Zenghui Pu, Maomao Zhao
A 70-year-old woman was adimittetd with subarachnoid haemorrhage. The patient underwent cerebral aneurysm embolization. On hospital day 14, the patient underwent a lumbar subarachnoid continuous drain insertion because of fever and enlarged ventricles were showed on the head computed tomography. On hospital day 19, the patient presented with remittent fever (peak at 39.1 °C) associated with altered mental status. Cerebro-Spinal Fluid (CSF) revealed white blood cell (WBC) count of 53484/mm3 (polymorphonucleocytes,75...
August 13, 2018: Antimicrobial Agents and Chemotherapy
Mike M Ruth, Jasper J N Sangen, Lian J Pennings, Jodie A Schildkraut, Wouter Hoefsloot, Cecile Magis-Escurra, Heiman F L Wertheim, Jakko van Ingen
Mycobacterium abscessus (Mab) causes difficult-to-treat pulmonary disease (Mab-PD). After the initial intravenous treatment, minocycline is recommended in the oral continuation phase of treatment. We determined minimum inhibitory concentrations, synergy and time-kill kinetics of minocycline against Mab. With MICs of 8-512 mg/l, rapid emergence of tolerance in time-kill assays and no synergy with other drugs used to treat Mab-PD, minocycline appears ineffective against Mab. These in vitro data question its role as a Mab-PD treatment modality...
August 13, 2018: Antimicrobial Agents and Chemotherapy
Alessandro Galluzzo, Massimo Imazio
Medical therapy of pericardial diseases is moving forward to the road of evidence-based medicine and has improved in the last years because of the first randomized clinical trials in the area as well as new therapeutic options for recurrent pericarditis. Areas covered: The present review will focus on more recent advances with a special emphasis on the treatment of pericarditis, the area with more significant improvements in the last years. Medline/Pubmed Library were systematically screened with two specific key searches: "pericarditis AND therapy" and "pericardial effusion AND therapy"...
August 14, 2018: Expert Review of Cardiovascular Therapy
Ali R Ahmadi, Maria Chicco, Russell N Wesson, Robert A Anders, Frank J M F Dor, Jan N M IJzermans, Tyler J Creamer, George M Williams, Zhaoli Sun, Andrew M Cameron
INTRODUCTION: Acute liver failure (ALF) affects 2000 Americans each year with no treatment options other than liver transplantation. We showed previously that mobilization of endogenous stem cells is protective against ALF in rodents. The objective of this study was to assess whether stem cell mobilizing drugs are lifesaving in a large animal preclinical model of ALF, to assess readiness for a clinical trial. METHODS: Male Yorkshire pigs (14-18 kg) were divided into 2 groups, control (n = 6) and treatment (n = 6)...
August 10, 2018: Annals of Surgery
Zen'ichiro Wajima, Toshiya Shiga, Kazuyuki Imanaga
Hypotension commonly accompanies combined epidural and general anesthesia, and intravenous bolus ephedrine and etilefrine are widely used to correct hypotension. We have noticed that systemic vascular resistance (SVR) transiently decreases just after intravenous bolus administration of these drugs. The goal of the present study was to investigate whether bolus administration of these drugs decrease SVR just after intravenous administration in combined epidural and general anesthesia patients. We investigated 40 patients who were scheduled for elective abdominal surgery...
August 10, 2018: Bioscience Trends
Antonio Del Casale, Serena Sorice, Alessio Padovano, Maurizio Simmaco, Stefano Ferracuti, Dorian A Lamis, Chiara Rapinesi, Gabriele Sani, Paolo Girardi, Georgios D Kotzalidis, Maurizio Pompili
BACKGROUND: Obsessive-compulsive disorder (OCD) is associated with affective and cognitive symptoms causing personal distress and reduced global functioning. These have considerable societal costs due to healthcare service utilization. OBJECTIVE: Our aim was to assess the efficacy of pharmacological interventions in OCD and clinical guidelines, providing a comprehensive overview of this field. METHODS: We searched the PubMed database for papers dealing with drug treatment of OCD, with a specific focus on clinical guidelines, treatments with antidepressants, antipsychotics, mood stabilizers, off-label medications, and pharmacogenomics...
August 13, 2018: Current Neuropharmacology
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