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Andy Clark

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https://www.readbyqxmd.com/read/29975016/corrigendum-validating-eaton-s-hypothesis-cubane-as-a-benzene-bioisostere
#1
Benjamin A Chalmers, Hui Xing, Sevan Houston, Charlotte Clark, Sussan Ghassabian, Andy Kuo, Benjamin Cao, Andrea Reitsma, Cody-Ellen P Murray, Jeanette E Stok, Glen M Boyle, Carly J Pierce, Stuart W Littler, David A Winkler, Paul V Bernhardt, Cielo Pasay, James J De Voss, James McCarthy, Peter G Parsons, Gimme H Walter, Maree T Smith, Helen M Cooper, Susan K Nilsson, John Tsanaktsidis, G Paul Savage, Craig M Williams
No abstract text is available yet for this article.
July 9, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29970883/dynamic-strain-determination-using-fibre-optic-cables-allows-imaging-of-seismological-and-structural-features
#2
Philippe Jousset, Thomas Reinsch, Trond Ryberg, Hanna Blanck, Andy Clarke, Rufat Aghayev, Gylfi P Hersir, Jan Henninges, Michael Weber, Charlotte M Krawczyk
Natural hazard prediction and efficient crust exploration require dense seismic observations both in time and space. Seismological techniques provide ground-motion data, whose accuracy depends on sensor characteristics and spatial distribution. Here we demonstrate that dynamic strain determination is possible with conventional fibre-optic cables deployed for telecommunication. Extending recently distributed acoustic sensing (DAS) studies, we present high resolution spatially un-aliased broadband strain data...
July 3, 2018: Nature Communications
https://www.readbyqxmd.com/read/29914411/access-to-primary-care-for-socio-economically-disadvantaged-older-people-in-rural-areas-exploring-realist-theory-using-structural-equation-modelling-in-a-linked-dataset
#3
John A Ford, Andy Jones, Geoff Wong, Allan Clark, Tom Porter, Nick Steel
BACKGROUND: Realist approaches seek to answer questions such as 'how?', 'why?', 'for whom?', 'in what circumstances?' and 'to what extent?' interventions 'work' using context-mechanism-outcome (CMO) configurations. Quantitative methods are not well-established in realist approaches, but structural equation modelling (SEM) may be useful to explore CMO configurations. Our aim was to assess the feasibility and appropriateness of SEM to explore CMO configurations and, if appropriate, make recommendations based on our access to primary care research...
June 19, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29880660/high-resolution-comparative-analysis-of-great-ape-genomes
#4
Zev N Kronenberg, Ian T Fiddes, David Gordon, Shwetha Murali, Stuart Cantsilieris, Olivia S Meyerson, Jason G Underwood, Bradley J Nelson, Mark J P Chaisson, Max L Dougherty, Katherine M Munson, Alex R Hastie, Mark Diekhans, Fereydoun Hormozdiari, Nicola Lorusso, Kendra Hoekzema, Ruolan Qiu, Karen Clark, Archana Raja, AnneMarie E Welch, Melanie Sorensen, Carl Baker, Robert S Fulton, Joel Armstrong, Tina A Graves-Lindsay, Ahmet M Denli, Emma R Hoppe, PingHsun Hsieh, Christopher M Hill, Andy Wing Chun Pang, Joyce Lee, Ernest T Lam, Susan K Dutcher, Fred H Gage, Wesley C Warren, Jay Shendure, David Haussler, Valerie A Schneider, Han Cao, Mario Ventura, Richard K Wilson, Benedict Paten, Alex Pollen, Evan E Eichler
Genetic studies of human evolution require high-quality contiguous ape genome assemblies that are not guided by the human reference. We coupled long-read sequence assembly and full-length complementary DNA sequencing with a multiplatform scaffolding approach to produce ab initio chimpanzee and orangutan genome assemblies. By comparing these with two long-read de novo human genome assemblies and a gorilla genome assembly, we characterized lineage-specific and shared great ape genetic variation ranging from single- to mega-base pair-sized variants...
June 8, 2018: Science
https://www.readbyqxmd.com/read/29606507/human-isl1-ventricular-progenitors-self-assemble-into-an-in-vivo-functional-heart-patch-and-preserve-cardiac-function-post-infarction
#5
Kylie S Foo, Miia L Lehtinen, Chuen Yan Leung, Xiaojun Lian, Jiejia Xu, Wendy Keung, Lin Geng, Terje R S Kolstad, Sebastian Thams, Andy On-Tik Wong, Nicodemus Wong, Kristine Bylund, Chikai Zhou, Xiaobing He, Shao-Bo Jin, Jonathan Clarke, Urban Lendahl, Ronald A Li, William E Louch, Kenneth R Chien
The generation of human pluripotent stem cell (hPSC)-derived ventricular progenitors and their assembly into a 3-dimensional in vivo functional ventricular heart patch has remained an elusive goal. Herein, we report the generation of an enriched pool of hPSC-derived ventricular progenitors (HVPs), which can expand, differentiate, self-assemble, and mature into a functional ventricular patch in vivo without the aid of any gel or matrix. We documented a specific temporal window, in which the HVPs will engraft in vivo...
July 5, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29437162/compilation-of-climate-data-from-heterogeneous-networks-across-the-hawaiian-islands
#6
Ryan J Longman, Thomas W Giambelluca, Michael A Nullet, Abby G Frazier, Kevin Kodama, Shelley D Crausbay, Paul D Krushelnycky, Susan Cordell, Martyn P Clark, Andy J Newman, Jeffrey R Arnold
Long-term, accurate observations of atmospheric phenomena are essential for a myriad of applications, including historic and future climate assessments, resource management, and infrastructure planning. In Hawai'i, climate data are available from individual researchers, local, State, and Federal agencies, and from large electronic repositories such as the National Centers for Environmental Information (NCEI). Researchers attempting to make use of available data are faced with a series of challenges that include: (1) identifying potential data sources; (2) acquiring data; (3) establishing data quality assurance and quality control (QA/QC) protocols; and (4) implementing robust gap filling techniques...
February 13, 2018: Scientific Data
https://www.readbyqxmd.com/read/29105912/how-much-do-direct-livestock-emissions-actually-contribute-to-global-warming
#7
Andy Reisinger, Harry Clark
Agriculture directly contributes about 10%-12% of current global anthropogenic greenhouse gas emissions, mostly from livestock. However, such percentage estimates are based on global warming potentials (GWPs), which do not measure the actual warming caused by emissions and ignore the fact that methane does not accumulate in the atmosphere in the same way as CO2 . Here, we employ a simple carbon cycle-climate model, historical estimates and future projections of livestock emissions to infer the fraction of actual warming that is attributable to direct livestock non-CO2 emissions now and in future, and to CO2 from pasture conversions, without relying on GWPs...
April 2018: Global Change Biology
https://www.readbyqxmd.com/read/29034807/andy-clark-surfing-uncertainty-prediction-action-and-the-embodied-mind-clark-andy-surfing-uncertainty-prediction-action-and-the-embodied-mind-new-york-ny-oxford-university-press-2016-424-pp-isbn-9780190217013-%C3%A2-19-99-hardback
#8
https://www.readbyqxmd.com/read/28925894/aerosol-a-novel-vehicle-for-pharmacotherapy-in-neonates
#9
Ronan MacLoughlin, Colin Telfer, Andy Clark, James Fink
BACKGROUND: Local delivery of drugs to the lungs of newborn infant represents an unmet need as no drugs have been approved. Potential benefits could be large. Development of aerosol for delivery of drugs to infants and newborn offers huge potential for better therapy. Newborn infants present unique challenges with regard to aerosol therapy. Efficient deposition of aerosolized medications on the neonate airway surface is hampered by anatomical features such as small airway geometries and physiological features such as exquisitely small tidal volumes, rapid breathing and unfavorable inhalation:exhalation ratios...
2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28776920/creating-an-innovative-youth-mental-health-service-in-the-united-kingdom-the-norfolk-youth-service
#10
Jon Wilson, Tim Clarke, Rebecca Lower, Uju Ugochukwu, Sarah Maxwell, Jo Hodgekins, Karen Wheeler, Andy Goff, Robert Mack, Rebecca Horne, David Fowler
Young people attempting to access mental health services in the United Kingdom often find traditional models of care outdated, rigid, inaccessible and unappealing. Policy recommendations, research and service user opinion suggest that reform is needed to reflect the changing needs of young people. There is significant motivation in the United Kingdom to transform mental health services for young people, and this paper aims to describe the rationale, development and implementation of a novel youth mental health service in the United Kingdom, the Norfolk Youth Service...
August 4, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28766476/general-steps-to-standardize-the-laboratory-measurement-of-serum-total-25-hydroxyvitamin-d
#11
Christopher T Sempos, Joseph M Betz, Johanna E Camara, Graham D Carter, Etienne Cavalier, Michael W Clarke, Kirsten G Dowling, Ramon A Durazo-Arvizu, Andrew N Hoofnagle, Andy Liu, Karen W Phinney, Kurtis Sarafin, Stephen A Wise, Paul M Coates
The Vitamin D Standardization Program (VDSP) has collaborated with numerous groups and agencies to assemble a set of tools, i.e., a reference measurement system, that can be used to establish the traceability of 25-hydroxyvitamin D [25(OH)D] assays to relevant reference measurement procedures and reference materials. This is done with the goal of verifying end-user laboratory performance using precise statistical criteria to determine whether a specific assay is standardized. The purpose of this paper was to outline a set of steps that routine clinical and research laboratories can use to standardize their 25(OH)D assays using these tools...
September 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28753852/desnt-a-poor-prognosis-category-of-human-prostate-cancer
#12
Bogdan-Alexandru Luca, Daniel S Brewer, Dylan R Edwards, Sandra Edwards, Hayley C Whitaker, Sue Merson, Nening Dennis, Rosalin A Cooper, Steven Hazell, Anne Y Warren, Rosalind Eeles, Andy G Lynch, Helen Ross-Adams, Alastair D Lamb, David E Neal, Krishna Sethia, Robert D Mills, Richard Y Ball, Helen Curley, Jeremy Clark, Vincent Moulton, Colin S Cooper
BACKGROUND: A critical problem in the clinical management of prostate cancer is that it is highly heterogeneous. Accurate prediction of individual cancer behaviour is therefore not achievable at the time of diagnosis leading to substantial overtreatment. It remains an enigma that, in contrast to breast cancer, unsupervised analyses of global expression profiles have not currently defined robust categories of prostate cancer with distinct clinical outcomes. OBJECTIVE: To devise a novel classification framework for human prostate cancer based on unsupervised mathematical approaches...
March 6, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28693812/predictions-precision-and-agentive-attention
#13
REVIEW
Andy Clark
Ransom, Fazelpour, and Mole (this journal - 2017) raise an important puzzle for the 'prediction error minimization' account of cognitive processing. That account depicts all cognitive processing as fundamentally in the business of minimizing prediction errors concerning the evolving flow of sensory information. One of the cornerstones of these highly ambitious, would-be unifying accounts is their depiction of attention as nothing other than the process of optimizing the precision (inverse variance) of critical prediction error signals...
November 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28614977/andy-clark-surfing-uncertainty-prediction-action-and-the-embodied-mind-clark-andy-surfing-uncertainty-prediction-action-and-the-embodied-mind-new-york-ny-oxford-university-press-2016-424-pp-isbn-9780190217013-%C3%A2-19-99-hardback
#14
https://www.readbyqxmd.com/read/28595091/detection-and-characterisation-of-bone-destruction-in-murine-rheumatoid-arthritis-using-statistical-shape-models
#15
James M Brown, Ewan Ross, Guillaume Desanti, Atif Saghir, Andy Clark, Chris Buckley, Andrew Filer, Amy Naylor, Ela Claridge
Rheumatoid arthritis (RA) is an autoimmune disease in which chronic inflammation of the synovial joints can lead to destruction of cartilage and bone. Pre-clinical studies attempt to uncover the underlying causes by emulating the disease in genetically different mouse strains and characterising the nature and severity of bone shape changes as indicators of pathology. This paper presents a fully automated method for obtaining quantitative measurements of bone destruction from volumetric micro-CT images of a mouse hind paw...
August 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28458677/photosynthesis-light-use-efficiency-and-yield-of-reduced-chlorophyll-soybean-mutants-in-field-conditions
#16
Rebecca A Slattery, Andy VanLoocke, Carl J Bernacchi, Xin-Guang Zhu, Donald R Ort
Reducing chlorophyll (chl) content may improve the conversion efficiency of absorbed photosynthetically active radiation into biomass and therefore yield in dense monoculture crops by improving light penetration and distribution within the canopy. The effects of reduced chl on leaf and canopy photosynthesis and photosynthetic efficiency were studied in two reportedly robust reduced-chl soybean mutants, Y11y11 and y9y9, in comparison to the wild-type (WT) "Clark" cultivar. Both mutants were characterized during the 2012 growing season whereas only the Y11y11 mutant was characterized during the 2013 growing season...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28369381/randomized-controlled-trial-of-the-tolerability-and-completion-of-maraviroc-compared-with-kaletra%C3%A2-in-combination-with-truvada%C3%A2-for-hiv-post-exposure-prophylaxis-mipep-trial
#17
RANDOMIZED CONTROLLED TRIAL
Ana Milinkovic, Paul Benn, Alejandro Arenas-Pinto, Nataliya Brima, Andrew Copas, Amanda Clarke, Martin Fisher, Gabriel Schembri, David Hawkins, Andy Williams, Richard Gilson
Objectives: Post-exposure prophylaxis (PEP) for HIV is often poorly tolerated and not completed. Alternative PEP regimens may improve adherence and completion, aiding HIV prevention. We conducted a randomized controlled trial of a maraviroc-based PEP regimen compared with a standard-of-care regimen using ritonavir-boosted lopinavir. Methods: Patients meeting criteria for PEP were randomized to tenofovir disoproxil/emtricitabine (200/245 mg) once daily plus ritonavir-boosted lopinavir (Kaletra ® 400/100 mg) or maraviroc 300 mg twice daily...
June 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28355839/attention-alters-predictive-processing
#18
Andy Clark
Firestone & Scholl (F&S) bracket many attentional effects as "peripheral," altering the inputs to a cognitive process without altering the processing itself. By way of contrast, I highlight an emerging class of neurocomputational models that imply profound, pervasive, nonperipheral influences of attention on perception. This transforms the landscape for empirical debates concerning possible top-down effects on perception.
January 2016: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28355064/plastic-bag-derived-microplastics-as-a-vector-for-metal-exposure-in-terrestrial-invertebrates
#19
Mark E Hodson, Calum A Duffus-Hodson, Andy Clark, Miranda T Prendergast-Miller, Karen L Thorpe
Microplastics are widespread contaminants in terrestrial environments but comparatively little is known about interactions between microplastics and common terrestrial contaminants such as zinc (Zn). In adsorption experiments fragmented HDPE bags c. one mm(2) in size showed similar sorption characteristics to soil. However, when present in combination with soil, concentrations of adsorbed Zn on a per mass basis were over an order of magnitude lower on microplastics. Desorption of the Zn was minimal from both microplastics and soil in synthetic soil solution (0...
April 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28353419/a-new-anti-mesothelin-antibody-targets-selectively-the-membrane-associated-form
#20
Kamal Asgarov, Jeremy Balland, Charline Tirole, Adeline Bouard, Virginie Mougey, Diana Ramos, António Barroso, Vincent Zangiacomi, Marine Jary, Stefano Kim, Maria Gonzalez-Pajuelo, Bernard Royer, Hans de Haard, Andy Clark, John Wijdenes, Christophe Borg
Mesothelin is a glycosylphosphatidylinositol (GPI)-anchored membrane protein that shows promise as a target for antibody-directed cancer therapy. High levels of soluble forms of the antigen represent a barrier to directing therapy to cellular targets. The ability to develop antibodies that can selectively discriminate between membrane-bound and soluble conformations of a specific protein, and thus target only the membrane-associated antigen, is a substantive issue. We show that use of a tolerance protocol provides a route to such discrimination...
April 2017: MAbs
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