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https://www.readbyqxmd.com/read/30547501/strategies-for-the-management-of-invasive-fungal-infections-due-to-filamentous-fungi-in-high-risk-hemato-oncological-patients
#1
C Vallejo, J Fortún
OBJECTIVE: In recent years, the introduction of new antifungals for the prevention of invasive fungal infections (IFIs) in hemato- oncological patients, particularly extended-spectrum azoles, has led to a change in the diagnostic and therapeutic strategies for established or suspected breakthrough IFI. The aim of the study was to identify the diagnostic and therapeutic strategies used in the management of IFIs in hemato-oncological patients in Spain, and to assess compliance with the recommendations of the consensus documents and clinical practice guidelines...
December 13, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/30547485/les-%C3%A3-volutions-des-modes-d-action-pour-agir-sur-les-in%C3%A3-galit%C3%A3-s-sociales-de-sant%C3%A3-dans-les-recommandations-politiques-%C3%A3-l-international-et-en-france
#2
Marion Porcherie, Blanche Le Bihan-Youinou, Jeanine Pommier
This article describes the changing modalities of action designed to address social inequalities in health recommended in France, in the light of WHO and other international guidelines. Content analysis of policy recommendations identified eleven categories of actions and five types of changes as a function of target populations and the resources deployed. Recommendations have evolved from interventions designed to improve access to primary care to interventions on the social determinants of health, from reinforcement of individual capacities to global empowerment, from interventions on target populations to social inclusion of everyone, from promotion of health investments to increased financial regulation, from a favourable public health policies approach to a health approach in all policies...
September 6, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/30546972/an-ai-based-heart-failure-treatment-adviser-system
#3
Zhuo Chen, Elmer Salazar, Kyle Marple, Sandeep R Das, Alpesh Amin, Daniel Cheeran, Lakshman S Tamil, Gopal Gupta
Management of heart failure is a major health care challenge. Healthcare providers are expected to use best practices described in clinical practice guidelines, which typically consist of a long series of complex rules. For heart failure management, the relevant guidelines are nearly 80 pages long. Due to their complexity, the guidelines are often difficult to fully comply with, which can result in suboptimal medical practices. In this paper, we describe a heart failure treatment adviser system that automates the entire set of rules in the guidelines for heart failure management...
2018: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/30546969/guideline-approaches-for-cardioendocrine-disease-surveillance-and-treatment-following-spinal-cord-injury
#4
REVIEW
Mark S Nash, James L J Bilzon
Purpose of Review: Persons with spinal cord injuries (SCI) commonly experience individual risks and coalesced health hazards of the cardiometabolic syndrome (CMS). This review will examinethe role of exercise and nutritional intervention as countermeasures to these disease risks. Recent Findings: The CMS hazards of overweight/obesity, insulin resistance, hypertension, and dyslipidemia are strongly associated with physical deconditioning and are common after SCI...
2018: Current Physical Medicine and Rehabilitation Reports
https://www.readbyqxmd.com/read/30546797/regular-medications-prescribed-to-elderly-neurosurgical-inpatients-and-the-impact-of-hospitalization-on-potentially-inappropriate-medications
#5
Narushi Sugii, Hiroyuki Fujimori, Naoaki Sato, Akira Matsumura
Objective: This study aimed to evaluate the regular medications prescribed to elderly neurosurgical inpatients in community hospitals in Japan. Materials and Methods: Elderly patients (aged ≥ 65 years) who had been admitted to neurosurgery departments from April 2015 to March 2017 were enrolled in this study. We collected data on regular medications at the time of admission and discharge. Furthermore, we retrospectively analyzed factors associated with potentially inappropriate medications (PIMs). PIMs were defined as polypharmacy (≥ 6 medications used concurrently) or taking any of the unfavorable medications on the "list of drugs to be prescribed with special caution" in the "Guidelines for Medical Treatment and Its Safety in the Elderly 2015"...
November 2018: Journal of Rural Medicine: JRM
https://www.readbyqxmd.com/read/30546465/clinicopathological-features-of-t1-colorectal-carcinomas-with-skip-lymphovascular-invasion
#6
Yuta Sato, Shin-Ei Kudo, Katsuro Ichimasa, Shingo Matsudaira, Yuta Kouyama, Kazuki Kato, Toshiyuki Baba, Kunihiko Wakamura, Takemasa Hayashi, Toyoki Kudo, Noriyuki Ogata, Yuichi Mori, Masashi Misawa, Naoya Toyoshima, Tomoyuki Ishigaki, Yusuke Yagawa, Hiroki Nakamura, Tatsuya Sakurai, Yukiko Shakuo, Kenichi Suzuki, Yui Kudo, Shigeharu Hamatani, Fumio Ishida, Hideyuki Miyachi
With recent advances in endoscopic treatment, many T1 colorectal carcinomas (CRCs) are resected endoscopically with a negative margin. However, some lesions exhibit skip lymphovascular invasion (SLVI), which is defined as the discontinuous foci of the tumor cells within the colon wall. The aim of the present study was to reveal the clinicopathological features of T1 CRCs with SLVI and validate the Japanese guidelines regarding SLVI. A total of 741 patients with T1 CRCs that were resected surgically between April 2001 and October 2016 in our hospital were divided into two groups: With SLVI and without SLVI...
December 2018: Oncology Letters
https://www.readbyqxmd.com/read/30546408/assessment-of-levels-of-d-dimer-and-interferon-%C3%AE-in-pediatric-patients-with-mycoplasma-pneumoniae-pneumonia-and-its-clinical-implication
#7
Xiaoqiu Jin, Ying Zhu, Yingchun Zhang, Jing Chen, Li Rong, Xuesong Zhao
Levels of D-dimer and interferon-γ (INF-γ) in pediatric patients with Mycoplasma pneumoniae pneumonia (MPP) were assessed to explore its clinical implication in evaluating the disease severity and patients' prognosis. Enrolled in this study as subjects were 185 pediatric patients with MPP who were admitted to the Department of Pediatrics of the Second Affiliated Hospital of Qiqihar Medical University and the First Hospital of Qiqihar City from January 2017 to October 2017 and 115 healthy children who underwent physical examination during the same time period...
December 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30546252/macrogol-polyethylene-glycol-4000-without-electrolytes-in-the-symptomatic-treatment-of-chronic-constipation-a-profile-of-its-use
#8
Katherine A Lyseng-Williamson
Macrogol 4000, a biologically inert, non-absorbable osmotic laxative, is a highly effective and well-tolerated first-line option for the treatment of the symptoms of chronic idiopathic/functional constipation in children and adults. High-molecular-weight (HMW) macrogols ± electrolytes have generally similar efficacy profiles; however, the taste of macrogol 4000 is generally preferred over that of macrogol 3350 + electrolytes. Macrogol 4000 is more effective than lactulose in improving stool frequency and consistency, and is associated with less vomiting and flatulence...
2018: Drugs & Therapy Perspectives: for Rational Drug Selection and Use
https://www.readbyqxmd.com/read/30546086/evidence-and-consensus-based-recommendations-for-the-use-of-pegvaliase-in-adults-with-phenylketonuria
#9
Nicola Longo, David Dimmock, Harvey Levy, Krista Viau, Heather Bausell, Deborah A Bilder, Barbara Burton, Christel Gross, Hope Northrup, Fran Rohr, Stephanie Sacharow, Amarilis Sanchez-Valle, Mary Stuy, Janet Thomas, Jerry Vockley, Roberto Zori, Cary O Harding
PURPOSE: Phenylketonuria (PKU) is a rare metabolic disorder that requires life-long management to reduce phenylalanine (Phe) concentrations within the recommended range. The availability of pegvaliase (PALYNZIQ™, an enzyme that can metabolize Phe) as a new therapy necessitates the provision of guidance for its use. METHODS: A Steering Committee comprising 17 health-care professionals with experience in using pegvaliase through the clinical development program drafted guidance statements during a series of face-to-face meetings...
December 14, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/30545997/systemic-mastocytosis-version-2-2019-nccn-clinical-practice-guidelines-in-oncology
#10
Jason Gotlib, Aaron T Gerds, Prithviraj Bose, Mariana C Castells, Michael W Deininger, Ivana Gojo, Krishna Gundabolu, Gabriela Hobbs, Catriona Jamieson, Brandon McMahon, Sanjay R Mohan, Vivian Oehler, Stephen Oh, Eric Padron, Philip Pancari, Nikolaos Papadantonakis, Animesh Pardanani, Nikolai Podoltsev, Raajit Rampal, Erik Ranheim, Lindsay Rein, David S Snyder, Brady L Stein, Moshe Talpaz, Swapna Thota, Martha Wadleigh, Katherine Walsh, Mary Anne Bergman, Hema Sundar
Mastocytosis is a group of heterogeneous disorders resulting from the clonal proliferation of abnormal mast cells and their accumulation in the skin and/or in various extracutaneous organs. Systemic mastocytosis is the most common form of mastocytosis diagnosed in adults, characterized by mast cell infiltration of one or more extracutaneous organs (with or without skin involvement). The identification of KIT D816V mutation and the emergence of novel targeted therapies have significantly improved the diagnosis and treatment of systemic mastocytosis...
December 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/30545990/nccn-guidelines-insights-thyroid-carcinoma-version-2-2018
#11
Robert I Haddad, Christian Nasr, Lindsay Bischoff, Naifa Lamki Busaidy, David Byrd, Glenda Callender, Paxton Dickson, Quan-Yang Duh, Hormoz Ehya, Whitney Goldner, Megan Haymart, Carl Hoh, Jason P Hunt, Andrei Iagaru, Fouad Kandeel, Peter Kopp, Dominick M Lamonica, Bryan McIver, Christopher D Raeburn, John A Ridge, Matthew D Ringel, Randall P Scheri, Jatin P Shah, Rebecca Sippel, Robert C Smallridge, Cord Sturgeon, Thomas N Wang, Lori J Wirth, Richard J Wong, Alyse Johnson-Chilla, Karin G Hoffmann, Lisa A Gurski
The NCCN Guidelines for Thyroid Carcinoma provide recommendations for the management of different types of thyroid carcinoma, including papillary, follicular, Hürthle cell, medullary, and anaplastic carcinomas. These NCCN Guidelines Insights summarize the panel discussion behind recent updates to the guidelines, including the expanding role of molecular testing for differentiated thyroid carcinoma, implications of the new pathologic diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features, and the addition of a new targeted therapy option for BRAF V600E-mutated anaplastic thyroid carcinoma...
December 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/30545972/diagnosis-of-pulmonary-hypertension
#12
Adaani Frost, David Badesch, J Simon R Gibbs, Deepa Gopalan, Dinesh Khanna, Alessandra Manes, Ronald Oudiz, Toru Satoh, Fernando Torres, Adam Torbicki
A revised diagnostic algorithm provides guidelines for the diagnosis of patients with suspected pulmonary hypertension, both prior to and following referral to expert centres, and includes recommendations for expedited referral of high-risk or complicated patients and patients with confounding comorbidities. New recommendations for screening high-risk groups are given, and current diagnostic tools and emerging diagnostic technologies are reviewed.
December 13, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30545969/chronic-thromboembolic-pulmonary-hypertension
#13
Nick H Kim, Marion Delcroix, Xavier Jais, Michael M Madani, Hiromi Matsubara, Eckhard Mayer, Takeshi Ogo, Victor F Tapson, Hossein-Ardeschir Ghofrani, David P Jenkins
Chronic thromboembolic pulmonary hypertension (CTEPH) is a complication of pulmonary embolism and a major cause of chronic PH leading to right heart failure and death. Lung ventilation/perfusion scintigraphy is the screening test of choice; a normal scan rules out CTEPH. In the case of an abnormal perfusion scan, a high-quality pulmonary angiogram is necessary to confirm and define the pulmonary vascular involvement and prior to making a treatment decision. PH is confirmed with right heart catheterisation, which is also necessary for treatment determination...
December 13, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30545816/issues-in-building-a-nursing-home-syndromic-surveillance-system-with-textmining-longitudinal-observational-study
#14
Tiba Delespierre, Loic Josseran
BACKGROUND: New nursing homes (NH) data warehouses fed from residents' medical records allow monitoring the health of elderly population on a daily basis. Elsewhere, syndromic surveillance has already shown that professional data can be used for public health (PH) surveillance but not during a long-term follow-up of the same cohort. OBJECTIVE: This study aimed to build and assess a national ecological NH PH surveillance system (SS). METHODS: Using a national network of 126 NH, we built a residents' cohort, extracted medical and personal data from their electronic health records, and transmitted them through the internet to a national server almost in real time...
December 13, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/30545542/primary-signet-ring-cell-carcinoma-of-the-cervix-a-case-report-with-review-of-the-literature
#15
You-Chen Wang, Yen-Lin Yu, Chung-Wei Fan, Shih-Yin Huang
OBJECTIVE: Primary cervical signet ring cell carcinoma (PCSRCC) is extremely rare. In this paper, we describe a case presenting with PCSRCC. CASE REPORT: The 48-year-old woman visited the gynecological department because of postmenopausal bleeding. A cervical mass was discovered through pelvic examination, and the biopsy results indicated a poorly differentiated adenocarcinoma with a signet ring cell pattern. Colonoscopy revealed external compression of the rectum without intraluminal mucosal lesions...
December 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/30545516/ventilation-perfusion-spect-imaging-diagnosing-other-cardiopulmonary-diseases-beyond-pulmonary-embolism
#16
REVIEW
Marika Bajc, Ari Lindqvist
Ventilation/perfusion single-photon emission computed tomography (V/P SPECT) is the scintigraphic technique recommended primarily for the diagnosis of acute pulmonary embolism (PE) and is golden standard for the diagnosis of chronic PE. Furthermore, interpreting ventilation and corresponding perfusion images enables pattern recognition of many other cardiopulmonary disorders that affect lung function and also allows quantification of their extent. Using Technegas for the ventilation imaging, grading of small airway disease in COPD is possible and the method is recommended for PE diagnosis in patients with severe COPD that is not possible with radiolabelled liquid aerosols...
January 2019: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/30545440/setdb1-regulates-smad7-expression-for-breast-cancer-metastasis
#17
Tae Young Ryu, Kwangho Kim, Seon-Kyu Kim, Jung-Hwa Oh, Jeong-Ki Min, Cho-Rok Jung, Mi-Young Son, Dae-Soo Kim, Hyun-Soo Cho
Breast cancer (BRC) is the most invasive cancer in women. Although the survival rate of BRC is gradually increasing due to improved screening systems, development of novel therapeutic targets for inhibition of BRC proliferation, metastasis and recurrence have been constantly needed. Thus, in this study, we identified overexpression of SETDB1 (SET Domain Bifurcated 1), a histone methyltransferase, in RNA-seq data of BRC derived from TCGA portal. In Gene Ontology (GO) analysis, cell migration-related GO terms were enriched, and we confirmed down-regulation of cell migration/invasion and alteration of EMT /MET markers after knockdown of SETDB1...
December 14, 2018: BMB Reports
https://www.readbyqxmd.com/read/30545434/statins-the-burglar-of-memory
#18
Tara Nicole Downs
Alzheimer's disease is becoming more predominant in our aging population. Statin medications have been reported to contribute to cognitive impairment. Updated cholesterol treatment guidelines significantly increase the proportion of people eligible for treatment with statins. Therefore, uncommon adverse effects related to this medication class have the potential to impact health care by increasing cognitive impairment and/or contributing to statin treatment avoidance. CASE : An 83-year-old Caucasian male was seen in a cognitive evaluation clinic for noticeable memory decline...
December 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/30545432/management-of-primary-sj%C3%A3-gren-s-syndrome
#19
Leisa L Marshall, Gregg A Stevens
OBJECTIVE : Review the clinical manifestations and treatment of primary Sjögren's syndrome. DATA SOURCES : Articles indexed in PubMed, Scopus, and the Cochrane Library in the past 10 years using the key words "Sjögren," "Sjögren's syndrome," "Sjögren's disease," and "Sjögren's syndrome AND treatment." Primary sources were used to locate additional resources. STUDY SELECTION AND DATA EXTRACTION : Forty-six publications were reviewed and criteria supporting the primary objective were used to identify useful resources...
December 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/30545415/current-state-and-future-directions-of-technology-based-ecological-momentary-assessments-and-interventions-for-major-depressive-disorder-protocol-for-a-systematic-review
#20
Desirée Colombo, Azucena Garcia Palacios, Javier Fernandez Alvarez, Andrea Patané, Michelle Semonella, Pietro Cipresso, Marta Kwiatkowska, Giuseppe Riva, Cristina Botella
BACKGROUND: Ecological momentary assessments (EMAs) and ecological momentary interventions (EMIs) represent a novel approach for the assessment and delivery of psychological support to depressed patients in daily life. Beyond the classical paper-and-pencil daily diaries, the more recent progresses in Information and Communication Technologies (ICT) enabled researchers to bring all the needed processes together in only one device, i.e., response signaling, repeated symptom collection, information storage, secure data transfer, and psychological support delivery...
December 13, 2018: Systematic Reviews
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