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https://www.readbyqxmd.com/read/30118917/how-to-improve-clinical-practice-on-forced-medication-in-psychiatric-practice-suggestions-from-the-eunomia-european-multicentre-study
#1
Mario Luciano, Corrado De Rosa, Gaia Sampogna, Valeria Del Vecchio, Vincenzo Giallonardo, Michele Fabrazzo, Francesco Catapano, George Onchev, Jiri Raboch, Anastasia Mastrogianni, Zahava Solomon, Algirdas Dembinskas, Petr Nawka, Andrzej Kiejna, Francisco Torres-Gonzales, Lars Kjellin, Kallert Thomas, Fiorillo Andrea
BACKGROUND: The decision to adopt forced medication in psychiatric care is particularly relevant from a clinical and ethical viewpoint. The European Commission has funded the EUNOMIA study in order to develop European recommendations for good clinical practice on coercive measures, including forced medication. METHODS: The recommendations on forced medication have been developed in 11 countries with the involvement of national clinical leaders, key-professionals and stakeholders' representatives...
August 14, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/30116852/-update-of-the-german-s3-guideline-on-atraumatic-femoral-head-necrosis-in-adults
#2
REVIEW
Andreas Roth, Johannes Beckmann, Klaus Bohndorf, Christian Heiß, Marcus Jäger, Stefan Landgraeber, Uwe Maus, Ulrich Nöth, Klaus M Peters, Christof Rader, Stephan Reppenhagen, Ulrich Smolenski, Ina Kopp, Markus Tingart
The update of the German S3 guideline on atraumatic femoral head necrosis in adults aims to provide an overview of diagnosis and treatment. All clinical studies, systematic reviews, and meta-analyses published in German or English between 01.05.2013 and 30.04.2017 were included. Of 427 studies, 28 were suitable for analysis. Risk factors are corticosteroids, chemotherapy, kidney transplants, hemoglobinopathies, and alcoholism. Differential diagnoses are for example bone marrow edema, insufficiency fracture, and destructive arthropathy...
August 16, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/30116116/feasibility-and-effects-of-structured-physical-exercise-interventions-in-adults-with-relapsing-remitting-multiple-sclerosis-a-pilot-study
#3
Elisabet Guillamó, Álvaro Cobo-Calvo, Guillermo R Oviedo, Noémie Travier, Juan Álamo, Oscar A Niño-Mendez, Antonio Martínez-Yelamos, Sergio Martínez-Yelamos, Casimiro Javierre
Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS...
September 2018: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/30114870/recurrent-pregnancy-loss-a-summary-of-international-evidence-based-guidelines-and-practice
#4
Ying Hong Li, Anthony Marren
BACKGROUND: Recurrent pregnancy loss (RPL) is defined as two or more pregnancy losses. It affects <5% of couples. There are many proposed causes; however, in a significant proportion of cases, the cause is unknown. OBJECTIVE: The aim of this paper is to provide a summary of the aetiology, investigations and management of RPL, which is based on the three most recent international guidelines on RPL (European Society of Human Reproduction and Embryology, 2017; American Society for Reproductive Medicine, 2012; and the Royal College of Obstetricians and Gynaecologists, 2011)...
July 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/30113491/surgical-decompression-of-the-lateral-femoral-cutaneous-nerve-lfcn-for-meralgia-paresthetica-treatment-experimental-or-state-of-the-art-a-single-center-outcome-analysis
#5
Karl Schwaiger, Paul Panzenbeck, Martin Purschke, Elisabeth Russe, René Kaplan, Klemens Heinrich, Patrick Mandal, Gottfried Wechselberger
Meralgia paresthetica (MP) is a rare lateral femoral cutaneous nerve-(LFCN)-mononeuropathy. Treatment for this disorder includes conservative and operative approaches; the latter is considered if conservative therapy fails. The most commonly used surgical approaches are decompression/neurolysis and avulsion/neurectomy. However, there are no definitive guidelines on the optimal surgical approach to be used. The purpose of this study was to evaluate the outcome of surgical decompression of the LFCN for the treatment of persistent MP with preservation of sensation along the distribution of the LFCN...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30113269/rationale-and-methods-of-the-idomeneo-health-outcomes-of-the-peripheral-arterial-disease-revascularisation-study-in-the-germanvasc-registry
#6
Eike Sebastian Debus, Levente Kriston, Thea Schwaneberg, Sandra Hischke, Henrik Christian Rieß, Martin Härter, Ursula Marschall, Hannes Federrath, Christian-Alexander Behrendt
BACKGROUND: Atherosclerotic disease of the lower extremity arteries (PAD) remains a significant burden on global healthcare systems with increasing prevalence. Various guidelines on the diagnosis and treatment of patients with PAD are available but they often lack a sufficient evidence base for high-grade recommendations since randomized and controlled trials (RCT) remain rare or are frequently subject to conflicts of interest. This registry trial aims to evaluate the outcomes of catheter-based endovascular revascularisations vs...
August 16, 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/30113226/antibiotic-utilization-prior-to-endourological-surgery-for-urolithiasis-endourological-society-survey-results
#7
Evan Clayton Carlos, Ramy F Youssef, Adam Geoffrey Kaplan, Daniel Arthur Wollin, Brenton B Winship, Brian H Eisner, Roger L Sur, Glenn M Preminger, Michael Eric Lipkin
INTRODUCTION: Ureteroscopy(URS) and percutaneous nephrolithotomy(PNL) are common procedures performed to treat kidney stones. Despite advances in technology/technique, serious infectious complications can occur. To better understand preoperative antibiotic administration patterns and adherence to guidelines from the American Urological Association(AUA) and the European Association of Urology(EAU), members of the Endourological Society were sent a clinical vignette-based survey to assess antibiotic use in a variety of pre-URS and pre-PNL scenarios...
August 16, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/30111949/unmet-needs-for-palliation-in-fibrotic-interstitial-lung-disease
#8
Sumeet Vimal Kishore Singhania, Shriram Sudhakar Shenoy
Chronic fibrotic interstitial lung disease (ILD) forms a substantial proportion of disabling lung diseases and leads to significant morbidity and mortality. The mortality of these patients when admitted to the Intensive Care Unit with acute respiratory worsening requiring mechanical ventilation can reach up to 90%. Indian law does not allow the physician to make the final decision about mechanical ventilation, we are forced to follow the wishes of the family despite knowing the extremely poor outcome of aggressive intervention and invasive ventilation...
July 2018: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/30108402/paediatric-insulin-injection-technique-the-softer-side
#9
Sanjay Kalra, Asma Al Deeb, Mudita Dhingra, Kenneth Strauss
This communication highlights the unique features of insulin injection technique in the paediatric age group. It describes the anatomical, neurodevelopmental and psychosocial characteristics of children and adolescents of various age groups. These are correlated to highlight 'best practices' or 'injection manner' which diabetes care providers and care givers should observe, in order to achieve a 'happy' and healthy insulin injection experience for the child. The softer side of paediatric insulin injection technique adds to existing guidelines on insulin delivery...
August 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/30107831/review-of-guidelines-on-expression-storage-and-transport-of-breast-milk-for-infants-in-hospital-to-guide-formulation-of-such-recommendations-in-sri-lanka
#10
Ranmali Rodrigo, Lisa H Amir, Della A Forster
BACKGROUND: Sick newborns in neonatal units who are unable to breastfeed are fed expressed breast milk. In Sri Lanka, most mothers stay in hospital throughout baby's stay to provide this milk freshly. In other countries mothers go home, express breast milk at home and bring it to hospital. There are concerns about the safety of transported expressed milk if used in a tropical middle-income country. The aim of this paper is to compare and contrast advice offered by different hospitals and organizations on how to express, store and transport breast milk safely...
August 14, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/30107754/qualitative-evaluation-of-a-guideline-supporting-shared-decision-making-for-extreme-preterm-birth
#11
Gregory Moore, Jessica Reszel, Thierry Daboval, Brigitte Lemyre, Conor Barker, Sandra Dunn
BACKGROUND AND OBJECTIVES: The decision to attempt resuscitation or provide palliative care at birth for extremely preterm infants between 22-25 weeks remains complex. The purpose of this study was to identify facilitators and barriers to implementation of a clinical practice guideline developed to support shared decision-making for these cases. METHODS: A purposeful sample of healthcare providers, involved in the care of one of five cases of anticipated extremely preterm birth, was recruited for interviews...
August 14, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30107709/-introduction-to-world-health-organization-guidelines-on-protecting-workers-from-potential-risks-of-manufactured-nanomaterials
#12
J L Tang, Y X Zheng
No abstract text is available yet for this article.
August 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/30107475/perspective-food-based-dietary-guidelines-in-europe-scientific-concepts-current-status-and-perspectives
#13
Angela Bechthold, Heiner Boeing, Inge Tetens, Lukas Schwingshackl, Ute Nöthlings
Food-based dietary guidelines (FBDGs) are important tools for nutrition policies and public health. FBDGs provide guidelines on healthy food consumption and are based on scientific evidence. In the past, disease prevention and nutrient recommendations dominated the process of establishing FBDGs. However, scientific advances and social developments such as changing lifestyles, interest in personalized health, and concerns about sustainability require a reorientation of the creation of FBDGs to include a wider range of aspects of dietary behavior...
August 11, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/30106874/part-i-minimum-quality-threshold-in-pre-clinical-sepsis-studies-mqtipss-for-study-design-and-humane-modeling-endpoints
#14
Basilia Zingarelli, Craig M Coopersmith, Susanne Drechsler, Philip Efron, John C Marshall, Lyle Moldawer, W Joost Wiersinga, Xianzhong Xiao, Marcin F Osuchowski, Christoph Thiemermann
Pre-clinical animal studies are mandatory before new treatments can be tested in clinical trials. However, their use in developing new therapies for sepsis has been controversial because of limitations of the models and inconsistencies with the clinical conditions. In consideration of the revised definition for clinical sepsis and septic shock (Sepsis-3), a Wiggers-Bernard Conference was held in Vienna in May 2017 to propose standardized guidelines on pre-clinical sepsis modeling. The participants conducted a literature review of 260 most highly cited scientific articles on sepsis models published between 2003 and 2012...
August 14, 2018: Shock
https://www.readbyqxmd.com/read/30105621/a-survey-on-practices-for-active-surveillance-of-carriage-of-multidrug-resistant-bacteria-in-hospitals-in-the-autonomous-community-of-valencia-spain
#15
Nuria Tormo, Eliseo Albert, Emilio Borrajo, Monserrat Bosque, Juan José Camarena, Victoria Domínguez, Encarnación Fuentes, Isabel Gascón, Bárbara Gomila, Nieves Gonzalo, Marta Jiménez, Olalla Martínez, José Miguel Nogueira, Nieves Orta, Josep Prat, Juan Carlos Rodríguez, Concepción Gimeno, David Navarro
A questionnaire-based cross-sectional study was conducted to gather information on current microbiological practices for active surveillance of carriage of multidrug-resistant (MDR) bacteria in hospitals from 14 health departments of the Autonomous Community of Valencia (ACV), Spain, which together provided medical attention to 3,271,077 inhabitants in 2017, approximately 70% of the population of the ACV. The survey consisted of 35 questions on MDR bacteria screening policies, surveillance approach chosen (universal vs...
August 13, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30105573/contemporary-management-of-the-newly-diagnosed-prostate-cancer-patient-with-metastatic-disease-at-presentation
#16
REVIEW
Lai Xu, Russell K Pachynski
PURPOSE OF REVIEW: Androgen deprivation therapy (ADT) has been the standard-of-care (SOC) for metastatic hormone-sensitive prostate cancer (mHSPC) since the middle of the twentieth century. Recently, several practice-changing trials have added new therapy options for these patients. Here we review these studies and discuss guidelines on treatment decision-making. RECENT FINDINGS: A trio of studies (GETUG-AFU15, STAMPEDE, CHAARTED) combining docetaxel chemotherapy with ADT all showed clinical benefit of the addition...
August 13, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/30105209/microcystins-in-water-and-in-microalgae-do-microcystins-as-microalgae-contaminants-warrant-the-current-public-alarm
#17
Stefano Scoglio
Microcystins have been the subject of increasingly alarming popular and scientific articles, which have taken as their unquestionable foundation the provisional Guideline of 1 μg/L established by the WHO Panel on microcystins levels in water, and mechanically translated by the Oregon government as 1 μg/g of Klamath Aphanizomenon flos aquae microalgae. This article underlines the significant limitations and ultimately scientific untenability of the WHO Guideline on microcystins in water, for being based on testing methodologies which may lead to a significant overestimation of the toxicity of microcystins...
2018: Toxicology Reports
https://www.readbyqxmd.com/read/30104795/prior-caesarean-section-and-likelihood-of-vaginal-birth-2012-2016-china
#18
Yi Mu, Xiaohong Li, Jun Zhu, Zheng Liu, Mingrong Li, Kui Deng, Changfei Deng, Qi Li, Leni Kang, Yanping Wang, Juan Liang
Objective: To examine the trends and safety of vaginal birth after caesarean section around the period of the one-child policy relaxation in China. Methods: We used data from China's National Maternal Near Miss Surveillance System between 2012 and 2016. To examine trends in vaginal birth after caesarean section, we used Poisson regression with a robust variance estimator. We also assessed the association between vaginal birth after caesarean section and maternal and perinatal outcomes...
August 1, 2018: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/30104418/data-independent-acquisition-based-swath-ms-for-quantitative-proteomics-a-tutorial
#19
REVIEW
Christina Ludwig, Ludovic Gillet, George Rosenberger, Sabine Amon, Ben C Collins, Ruedi Aebersold
Many research questions in fields such as personalized medicine, drug screens or systems biology depend on obtaining consistent and quantitatively accurate proteomics data from many samples. SWATH-MS is a specific variant of data-independent acquisition (DIA) methods and is emerging as a technology that combines deep proteome coverage capabilities with quantitative consistency and accuracy. In a SWATH-MS measurement, all ionized peptides of a given sample that fall within a specified mass range are fragmented in a systematic and unbiased fashion using rather large precursor isolation windows...
August 13, 2018: Molecular Systems Biology
https://www.readbyqxmd.com/read/30104219/treatment-dilemmas-in-asymptomatic-children-with-primary-haemophagocytic-lymphohistiocytosis
#20
Giovanna Lucchini, Rebecca Marsh, Kimberly Gilmour, Austen Worth, Zohreh Nademi, Anupama Rao, Claire Booth, Persis Amrolia, Juliana Silva, Robert Chiesa, Robert Wynn, Kai Lehmberg, Itziar Astigarraga, Tayfun Gungor, Jan Stary, Despina Moshous, Marianne Ifversen, Daniel Zinn, Michael Jordan, Ashish Kumar, Takahiro Yasumi, Paul Veys, Kanchan Rao
Asymptomatic carriers of pathogenic bilallelic mutations in causative genes for primary haemophagocytic lymphohistiocytosis (HLH) are at high-risk of developing life-threatening HLH, which requires allogeneic haematopoietic stem cell transplantation (HSCT) to be cured. There are no guidelines on the management of these asymptomatic patients. We analysed the outcomes of pairs of index cases (ICs) and subsequently diagnosed asymptomatic family members (ACs) carrying the same genetic defect. We collected data from 22 HSCT Centres worldwide...
August 13, 2018: Blood
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