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Melanoma radiotherapy

Paul Lesueur, Valentin Calugaru, Catherine Nauraye, Dinu Stefan, Kim Cao, Evelyne Emery, Yves Reznik, Jean Louis Habrand, Thomas Tessonnier, Abdulhamid Chaikh, Jacques Balosso, Juliette Thariat
INTRODUCTION: The depth-dose distribution of a proton beam, materialized by the Bragg peak makes it an attractive radiation modality as it reduces exposure of healthy tissues to radiations, compared with photon therapy Prominent indications, based on a long-standing experience are: intraocular melanomas, low-grade skull-base and spinal canal malignancies. However, many others potential indications are under investigations such as the benign morbid conditions that are compatible with an extended life-expectancy: low grade meningiomas, paragangliomas, pituitary adenomas, neurinomas craniopharyngioma or recurrent pleomorphic adenomas...
December 1, 2018: Cancer Treatment Reviews
Yunteng Wu, Lizheng Wang, Xuhui Ma, Wei Guo, Guoxin Ren
BACKGROUND: Oral mucosal melanoma (OMM) is an aggressive tumor with an extremely low incidence, and the current TNM Staging System has classified all OMMs as high stage. However, controversy remains regarding the existence of early stage OMMs. PATIENTS AND METHODS: The clinical and pathological features, treatments and outcomes of 170 OMM patients treated in a single institution from January 2007 to July 2017 were retrospectively analyzed. Multivariate analysis was performed to identify significant prognostic factors for overall survival (OS)...
December 2018: Oral Oncology
Robin L Whitney, Janice F Bell, Daniel J Tancredi, Patrick S Romano, Richard J Bold, Ted Wun, Jill G Joseph
PURPOSE: Reducing acute care use is an important strategy for improving value in cancer care. However, little information is available to describe and compare population-level hospital use across cancer types. Our aim was to estimate unplanned hospitalization rates and to describe the reasons for hospitalization in a population-based cohort recently diagnosed with cancer. MATERIALS AND METHODS: California Cancer Registry data linked with administrative inpatient data were used to examine unplanned hospitalization among individuals diagnosed with cancer between 2009 and 2012 (n = 412,850)...
December 5, 2018: Journal of Oncology Practice
Lavinia Ferrante di Ruffano, Jacqueline Dinnes, Naomi Chuchu, Susan E Bayliss, Yemisi Takwoingi, Clare Davenport, Rubeta N Matin, Colette O'Sullivan, Derek Roskell, Jonathan J Deeks, Hywel C Williams
BACKGROUND: Early accurate detection of all skin cancer types is essential to guide appropriate management, reduce morbidity and improve survival. Basal cell carcinoma (BCC) is usually localised to the skin but has potential to infiltrate and damage surrounding tissue, while cutaneous squamous cell carcinoma (cSCC) and melanoma have a much higher potential to metastasise and ultimately lead to death. Exfoliative cytology is a non-invasive test that uses the Tzanck smear technique to identify disease by examining the structure of cells obtained from scraped samples...
December 3, 2018: Cochrane Database of Systematic Reviews
J M Mor, K R Koch, V Kakkassery, C Cursiefen, L M Heindl
BACKGROUND: Benign iridal tumors rarely necessitate a therapeutic intervention. In contrast, malignant tumors of the iris can threaten the patient's life and eyesight and require early treatment to prevent the development of metastases. OBJECTIVE: Presentation of current treatment options for iridal tumors with special emphasis on iridal melanoma. METHODS: This article gives an overview of the current literature based on a PubMed search as well as own clinical experience...
December 4, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Giulia Allavena, Barbara Del Bello, Paolo Tini, Nila Volpi, Giuseppe Valacchi, Clelia Miracco, Luigi Pirtoli, Emilia Maellaro
Cutaneous melanomas frequently metastasize to the brain, with temozolomide (TMZ) plus radiotherapy (RT) offering little control of these lesions. We tested whether trehalose, a natural glucose disaccharide proved to induce autophagy, could enhance the effect of TMZ and ionizing radiation (IR). In two melanoma cell lines (A375 and SK-Mel-28), which greatly differ in chemosensitivity and radiosensitivity, trehalose significantly inhibited short-term cell proliferation and also enhanced IR-induced cytostasis. Interestingly, in TMZ-resistant SK-Mel-28 cells, trehalose was more effective than TMZ, and combined trehalose + TMZ further reduced cell proliferation...
November 29, 2018: Journal of Cellular Physiology
M Lundberg, A Haapaniemi, J Hagstrom, S Juteau, M Hernberg, A A Makitie, S I Vento
BACKGROUND: To describe a cohort of sinonasal mucosal melanoma (SNMM) patients, and to assess if choice of surgical approach (open versus endoscopic) has impact on survival. METHODOLOGY: Adequate data on clinical presentation, treatment, and recurrence pattern were available for 58 consecutive patients treated for SNMM at the Helsinki University Hospital (HUH) between 1983 and 2016. RESULTS: The 5-year disease-specific survival (DSS) was 27% and overall survival 25% for the whole cohort...
November 24, 2018: Rhinology
Dong Hyun Jo, Jin Hyoung Kim, Jeong Hun Kim
Uveal melanoma is the most common intraocular primary malignant tumor in adults, and retinoblastoma is the one in children. Current mainstay treatment options include chemotherapy using conventional drugs and enucleation, the total removal of the eyeball. Targeted therapies based on profound understanding of molecular mechanisms of ocular tumors may increase the possibility of preserving the eyeball and the vision. Tyrosine kinases, which modulate signaling pathways regarding various cellular functions including proliferation, differentiation, and attachment, are one of the attractive targets for targeted therapies against uveal melanoma and retinoblastoma...
November 23, 2018: Archives of Pharmacal Research
Leila Heckel, Kate M Gunn, Patricia M Livingston
BACKGROUND: Family members are increasingly involved in the care of cancer patients, however many are not prepared for this challenging role. Intervention-based studies are valuable to inform the most appropriate and effective support for caregivers. Barriers in the recruitment of patient/caregiver dyads exist but the reasons for non-participation are less well understood. This analysis determined the factors associated with participation in a randomized controlled trial involving patient/caregiver dyads, reasons for non-participation and factors associated with these reasons...
November 21, 2018: BMC Medical Research Methodology
Kenji Miki, Nobuhiro Hata, Yousuke Kawano, Yuhei Michiwaki, Akira Nakamizo, Keita Uchino, Koji Iihara
No abstract text is available yet for this article.
November 2018: No Shinkei Geka. Neurological Surgery
Ayumu Takahashi, Akihito Kubo, Shohei Mizuno, Kenji Kasai, Nobuhiro Asai, Toshiyuki Yonezawa, Kenshi Kosaka, Masaki Nishimura, Hiroyuki Tanaka, Norihito Yokoe, Toyonori Tsuzuki, Akiyoshi Takami, Etsuro Yamaguchi
A 73-year-old man who was a current smoker complained of weakness in his limbs and slow movement and was diagnosed with primary lung melanoma with brain metastases. Following stereotactic brain radiotherapy, nivolumab was administrated. After the first cycle of nivolumab, his blood neutrophil count and hemoglobin levels started to decline. Excluding other possible causes, nivolumab was considered the most probable cause of bicytopenia. Nivolumab was not restarted, and the bicytopenia gradually recovered with no corticosteroid administration for this event...
November 19, 2018: Internal Medicine
Takanori Abe, Tatsuya Ohno, Masashi Koto, Yusuke Demizu, Hiroaki Suefuji, Hiroshi Tsuji, Tomoaki Okimoto, Yoshiyuki Shioyama, Jun-Ichi Saitoh, Katsuyuki Shirai, Kenji Nemoto, Takashi Nakano, Tadashi Kamada
BACKGROUND: This multi-institutional retrospective study focused on the clinical outcome of carbon-ion radiotherapy (C-ion RT) for non-squamous cell malignant tumors of the nasopharynx. METHODS: The Japan Carbon-ion Radiation Oncology Study Group collected and analyzed data for 43 patients with non-squamous cell malignant tumors of the nasopharynx treated with C-ion RT at four institutions in Japan. RESULTS: Twenty-nine patients had adenoid cystic carcinomas, seven had malignant melanomas, three had adenocarcinomas, two had mucoepidermoid carcinomas, and two had other pathologies...
November 18, 2018: Cancer Medicine
Solly Thomas, Bimal Patel, Sunitha S Varghese, Selvamani Backianathan
Neurocutaneous melanoma is a rare congenital syndrome associated with congenital melanocytic nevi with meningeal melanosis or melanoma. The disease is aggressive and has a high propensity for leptomeningeal metastases. We present the case history of a man with neurocutaneous melanoma managed with radical excision followed by hypofractionated adjuvant radiotherapy. One year, eight months later, he had a recurrence of the condition with leptomeningeal spread and was managed with re-excision of the recurrent lesion...
September 10, 2018: Curēus
Vivienne S Lee, Lucinda S McRobb, Vaughan Moutrie, Estavam D Santos, Timothy L Siu
Metastatic melanoma can be highly refractory to conventional radiotherapy and chemotherapy but combinatorial-targeted therapeutics are showing greater promise on improving treatment efficacy. Previous studies have shown that knockdown of Forkhead box M1 ( FOXM1 ) can sensitize various tumor types to radiation-induced cell death. The effect of combining radiation with a small molecule FOXM1 inhibitor, Siomycin A, on growth, death and migration of a metastatic melanoma cell line (SK-MEL-28) that overexpresses this pleiotropic cell cycle regulator was investigated...
November 2018: Oncology Letters
Vasco Bravo-Filho, Patrick Logan, Pablo Zoroquiain, Sultan Aldrees, Natàlia Vilà, Ayman Oweida, Rubens Belfort Neto, Miguel N Burnier
PURPOSE: To evaluate the effects of ranibizumab and amfenac in human uveal melanoma cell lines and to explore the ability of these compounds to sensitize uveal melanoma cells to radiation therapy. METHODS: The 92.1 human uveal melanoma cell line was cultured and subjected to the proposed treatment (ranibizumab, amfenac, and a combination of both). Proliferation, migration, and invasion assays of the 92.1 uveal melanoma cell line were assessed after pretreatment with ranibizumab (125 mg/mL), amfenac (150 nM), or a combination of both...
November 1, 2018: Arquivos Brasileiros de Oftalmologia
Eric D Brooks, Joe Y Chang
Considerable interest is being directed toward combining immune-checkpoint inhibition (ICI) with radiotherapy to improve response rates to ICI, which have been disappointingly low at around 15-30% among patients with advanced-stage cancers other than melanoma. Since a case report published in 2012, in which authors described the resolution of metastatic disease after irradiation of a single lesion in a patient who had been receiving ICI, hundreds of clinical trials have been launched with the aim of testing the safety and/or efficacy of radiotherapy in combination with immunotherapy, nearly all of which use this single-site irradiation, or 'abscopal', approach...
November 6, 2018: Nature Reviews. Clinical Oncology
Nian Liu, Kuan Song Wang, Min Qi, Ying Jun Zhou, Guang Yao Zeng, Juan Tao, Jian Da Zhou, Jiang Lin Zhang, Xiang Chen, Cong Peng
BACKGROUND: Vitex negundo L (Verbenaceae) is an aromatic shrub that is abundant in Asian countries. A series of compounds from Vitex negundo have been used in traditional Chinese medicine for the treatment of various diseases. Cutaneous melanoma is one of the most aggressive malignancies. A significant feature of melanoma is its resistance to traditional chemotherapy and radiotherapy; therefore, there is an urgent need to develop novel treatments for melanoma. METHODS: We first examined the effects of VB1 (vitexin compound 1) on cell viability by CCK-8 (cell counting kit) and Colony Formation Assay; And then, we analyzed the apoptosis and cell cycle by flow cytometry, verified apoptosis by Immunoblotting...
November 6, 2018: Journal of Experimental & Clinical Cancer Research: CR
M Kandel, C Allayous, S Dalle, L Mortier, S Dalac, C Dutriaux, M T Leccia, B Guillot, P Saiag, J P Lacour, D Legoupil, T Lesimple, F Aubin, M Beylot-Barry, F Brunet-Possenti, J P Arnault, F Granel-Brocard, P E Stoebner, A Dupuy, E Maubec, J J Grob, B Dreno, F Rotolo, A Ballon, S Michiels, C Lebbe, I Borget
PURPOSE: Since 2011, significant progress was observed in metastatic melanoma (MM), with the commercialisation of seven immunotherapies or targeted therapies, which showed significant improvement in survival. In France, in 2004, the cost of MM was estimated at €1634 per patient; this cost has not been re-estimated since. This study provided an update on survival and cost in real-life clinical practice. METHODS: Clinical and economic data (treatments, hospitalisations, radiotherapy sessions, visits, imaging and biological exams) were extracted from the prospective MelBase cohort, collecting individual data in 955 patients in 26 hospitals, from diagnosis of metastatic disease until death...
December 2018: European Journal of Cancer
Ilaria Porcellato, Chiara Brachelente, Livia De Paolis, Laura Menchetti, Serenella Silvestri, Monica Sforna, Gaia Vichi, Selina Iussich, Luca Mechelli
Human melanoma is one of the deadliest forms of cancer, with poor prognosis and high resistance to chemotherapy and radiotherapy. The discovery of immunosuppressive mechanisms in the human melanoma microenvironment led to the use of new prognostic markers and to the development of immunotherapies targeting immune checkpoint molecules. Immunoescape mechanisms in canine melanoma have not yet been investigated, and no such immunotherapy has been tested. The aim of this study was to provide preliminary data on the expression of transcription factor forkhead box protein P3 (FoxP3) and indoleamine 2,3-dioxygenase (IDO) in primary canine melanocytic tumors and to investigate their prognostic role...
October 31, 2018: Veterinary Pathology
John F Thompson, Hidde M Kroon
No abstract text is available yet for this article.
October 26, 2018: Annals of Surgical Oncology
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