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Melanoma radiotherapy

Amit Maity, Rosemarie Mick, Alexander C Huang, Sangeeth M George, Michael D Farwell, John N Lukens, Abigail T Berman, Tara C Mitchell, Josh Bauml, Lynn M Schuchter, Mark O'Hara, Lilie L Lin, Angela Demichele, John P Christodouleas, Naomi B Haas, Dana M Patsch, Stephen M Hahn, Andy J Minn, E John Wherry, Robert H Vonderheide
BACKGROUND: We conducted a phase I trial evaluating pembrolizumab+hypofractionated radiotherapy (HFRT) for patients with metastatic cancers. METHODS: There were two strata (12 patients each): (i) NSCLC/melanoma progressing on prior anti-PD-1 therapy, (ii) other cancer types; anti-PD-1-naive. Patients received 6 cycles of pembrolizumab, starting 1 week before HFRT. Patients had ≥2 lesions; only one was irradiated (8 Gy × 3 for first half; 17 Gy × 1 for second half in each stratum) and the other(s) followed for response...
October 15, 2018: British Journal of Cancer
Claudia Matteucci, Emanuela Balestrieri, Ayele Argaw-Denboba, Paola Sinibaldi-Vallebona
Cancer incidence and mortality, metastasis, drug resistance and recurrence are still the critical issues of oncological diseases. In this scenario, increasing scientific evidences demonstrate that the activation of human endogenous retroviruses (HERVs) is involved in the aggressiveness of tumors such as melanoma, breast, germ cell, renal, ovarian, liver and haematological cancers. In their dynamic regulation, HERVs have also proved to be important determinants of pluripotency in human embryonic stem cells (ESC) and of the reprogramming process of induced pluripotent stem cells (iPSCs)...
October 11, 2018: Seminars in Cancer Biology
Joanna Katarzyna Bujak, Rafał Pingwara, Michelle Hase Nelson, Kinga Majchrzak
Cancer immunotherapy is recently considered the most promising treatment for human patients with advanced tumors and could be effectively combined with conventional therapies such as chemotherapy or radiotherapy. Patients with hematological malignancies and melanoma have benefited greatly from immunotherapies such as, adoptive cell transfer therapy, experiencing durable remissions and prolonged survival. In the face of increasing enthusiasm for immunotherapy, particularly for the administration of tumor-specific T lymphocytes, the question arises whether this method could be employed to improve treatment outcomes for canine patients...
October 11, 2018: Acta Veterinaria Scandinavica
Heinz Schmidberger, Matthias Rapp, Anne Ebersberger, Silla Hey-Koch, Carmen Loquai, Stephan Grabbe, Arnulf Mayer
PURPOSE: Since the introduction of ipilimumab (IPI) for the treatment of patients with metastatic malignant melanoma, we have observed remarkable responses after hypofractionated whole brain irradiation (WBRT) or stereotactic radiotherapy (STX) for brain metastases of malignant melanoma. We sought to investigate the impact of the sequence of these treatment modalities. METHODS: We retrospectively evaluated the survival of melanoma patients with brain metastases who were treated with WBRT or STX and received IPI in close temporal relation between October 2010 and March 2015...
October 8, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
G F Yin, W Guo, X H Chen, Z Y Liu, Z G Huang
Objective: To study the clinical characteristics of mucosal melanoma in the head and neck, including the risk factors affecting distant metastasis, recurrence and survival rate, and to provide the basis for the individualized treatment of mucosal melanoma in the head and neck. Methods: The clinical data of 117 cases of mucosal melanoma in the head and neck treated from January 2004 to June 2016 in Beijing Tongren Hospital were analyzed retrospectively, and the risk factors affecting the prognosis, distant metastasis and local recurrence were analyzed...
September 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Jackelien G M van Beek, Gabrielle H S Buitendijk, Reinier Timman, Karin Muller, Gregorius P M Luyten, Dion Paridaens, Nicole C Naus, Emine Kiliç
PURPOSE: To report the quality of life and visual functioning in uveal melanoma patients treated with enucleation or fractionated stereotactic radiation therapy (fSRT). METHODS: Uveal melanoma (UM) patients treated with fSRT (n = 65) or enucleation (n = 48) participated in this prospective study. Questionnaires to measure anxiety (State-Trait Anxiety Inventory), subjective distress (Impact of Event Scale) and quality of life (EORTC-QLQ-C30 and National Eye Institute Visual Function Questionnaire (VFQ-25)) were obtained before treatment and 2, 6, 12, 24, 36 and 48 months after treatment...
October 3, 2018: Acta Ophthalmologica
Aman Sharma, Marloes Duijm, Esther Oomen-de Hoop, Joachim G Aerts, Cornelis Verhoef, Mischa Hoogeman, Joost Jan Nuyttens
BACKGROUND: Stereotactic body radiotherapy (SBRT) for pulmonary oligometastatic disease achieves excellent treatment outcomes in terms of local control and toxicity. Patients treated with SBRT are often elderly and have multiple co-morbidities. This subset of patients may experience different survival as compared to young and fit patients subjected to radical metastasectomies. The purpose of this retrospective study was to evaluate OS and identify factors associated with OS for inoperable pulmonary oligometastases treated with SBRT...
October 3, 2018: Acta Oncologica
Carlo M Oranges, Giovanni Sisti, Dimitrios Nasioudis, Mathias Tremp, Pietro G DI Summa, Daniel F Kalbermatten, René D Largo, Dirk J Schaefer
BACKGROUND/AIM: Hard palate melanoma is an extremely rare and aggressive tumor arising from the mucosal epithelium of the oral cavity. The aim of this study was to analyze epidemiology, loco-regional treatment patterns and survival outcomes of this disease. MATERIALS AND METHODS: The National Cancer Institute's Surveillance Epidemiology and End Results (SEER) database was searched for all cases of hard palate melanoma diagnosed between 1973 and 2012. The Kaplan-Meier method was used to calculate overall survival rate, log-rank test to compare survivals of different subgroups, and Cox hazard regression analysis to determine independent predictors of overall survival...
October 2018: Anticancer Research
Carol L Shields, Kareem Sioufi, Archana Srinivasan, Maura DiNicola, Babak Masoomian, Laura E Barna, Vladislav P Bekerman, Emil A T Say, Arman Mashayekhi, Jacqueline Emrich, Lydia Komarnicky, Jerry A Shields
Importance: Early detection of choroidal melanoma at a small tumor size is emphasized in the literature. However, there is little published information on the specific risks of plaque-irradiated small choroidal melanoma on visual acuity and metastasis. Objective: To analyze outcomes of plaque radiotherapy for small choroidal melanoma 3 mm in thickness or less. Design, Setting, and Participants: This retrospective noncomparative series at a tertiary referral center included 1780 consecutive patients who had received plaque radiotherapy treatment for small choroidal melanoma...
September 27, 2018: JAMA Ophthalmology
Bagher Farhood, Hadi Samadian, Mahdi Ghorbani, Seyed Salman Zakariaee, Courtney Knaup
Neutron capture therapy (NCT) is a targeted radiotherapy for cancer treatment. In this method, neutrons with a spectra/specific energy (depending on the type of agent used for NCT) are captured with an agent that has a high cross-section with these neutrons. There are some agents that have been proposed in NCT including 10 B, 157 Gd and 33 S. Among these agents, only 10 B is used in clinical trials. Application of 157 Gd is limited to in-vivo and in-vitro research. In addition, 33 S has been applied in the field of Monte Carlo simulation...
September 2018: Reports of Practical Oncology and Radiotherapy
A Baus, D Culie, L T Duong, A Ben Lakhdar, J-B Schaaf, F Janot, F Kolb
Clear cell sarcomas (SCC), also called "soft-tissue melanoma", are rare and aggressive tumors that preferentially affect the lower limbs (tendons and fasciae) and which have also been described in head and neck localizations. Their clinical and immunohistochemical mimicry with melanoma makes it difficult to diagnose sarcomas. SCC treatment is mainly focused on large-scale resection surgery with adjuvant radiotherapy because of their low chemo-sensitivity and extreme lymphophilia. In case of head and neck localization, these treatments may lead to function and aesthetic sequelae thus requiring the use of modern techniques of reconstructive surgery...
September 24, 2018: Annales de Chirurgie Plastique et Esthétique
David Miguel, Jesús María de Frutos-Baraja, Francisco López-Lara, María Antonia Saornil, Ciro García-Álvarez, Pilar Alonso, Patricia Diezhandino
Purpose: To assess the influence of the radiobiological doses, tumor, and treatment features on retinopathy, cataracts, retinal detachment, optic neuropathy, vitreous hemorrhage, and neovascular glaucoma at the authors' institution after brachytherapy for posterior uveal melanoma. Material and methods: Medical records of 243 eyes with uveal melanoma, treated by iodine brachytherapy between 1996 and 2016 at a single center were analyzed. Clinical and radiotherapy data were extracted from a dedicated database...
August 2018: Journal of Contemporary Brachytherapy
David Miguel, Jesús María de Frutos-Baraja, Francisco López-Lara, María Antonia Saornil, Ciro García-Álvarez, Pilar Alonso, Patricia Diezhandino
Purpose: To assess influence of the radiobiological doses, tumor, and treatment features on local control, enucleation rates, overall and disease-specific survival rates after brachytherapy for posterior uveal melanoma. Material and methods: Local control, enucleation, overall and disease-specific survival rates were evaluated on the base of 243 patients from 1996 through 2016, using plaques loaded with iodine sources. Clinical and radiotherapy data were extracted from a dedicated prospective database...
August 2018: Journal of Contemporary Brachytherapy
François Lux, Vu Long Tran, Eloïse Thomas, Sandrine Dufort, Fabien Rossetti, Matteo Martini, Charles Truillet, Tristan Doussineau, Guillaume Bort, Franck Denat, Frédéric Boschetti, Goran Angelovski, Alexandre Detappe, Yannick Crémillieux, Nathalie Mignet, Bich-Thuy Doan, Benoit Larrat, Sébastien Meriaux, Emmanuel Barbier, Stéphane Roux, Peter Fries, Andreas Müller, Marie-Caline Abadjian, Carolyn Anderson, Emmanuelle Canet-Soulas, Penelope Bouziotis, Muriel Barberi-Heyob, Céline Frochot, Camille Verry, Jacques Balosso, Michael Evans, Jacqueline Sidi-Boumedine, Marc Janier, Karl Butterworth, Stephen McMahon, Kevin Prise, Marie-Thérèse Aloy, Dominique Ardail, Claire Rodriguez-Lafrasse, Erika Porcel, Sandrine Lacombe, Ross Berbeco, Awatef Allouch, Jean-Luc Perfettini, Cyrus Chargari, Eric Deutsch, Géraldine Le Duc, Olivier Tillement
AGuIX® are sub-5 nm nanoparticles made of a polysiloxane matrix and gadolinium chelates. This nanoparticle has been recently accepted in clinical trials in association with radiotherapy. This review will summarize the principal preclinical results that have led to first in man administration. No evidence of toxicity has been observed during regulatory toxicity tests on two animal species (rodents and monkeys). Biodistributions on different animal models have shown passive uptake in tumours due to enhanced permeability and retention effect combined with renal elimination of the nanoparticles after intravenous administration...
September 18, 2018: British Journal of Radiology
M X Chen, Y M Liu, W B Wei
Radiation treatment, including episcleral plaque radiotherapy, stereotactic radiosurgery, proton beam therapy and so on, is the primary eye-conserving choice for uveal melanoma. But the complications resulted from radiotherapy's nonselective kill to tumor cells can be visual-threatening and eventually result in the enucleation of eyeball. This review summarizes current radiation strategies for uveal melanoma and how these complications occur, develop and present, in the hope that it could provide insights for the radiation interventions and diagnosis of radiative complications...
September 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Ahmad Walid Ayas, Stefan Grau, Karolina Jablonska, Daniel Ruess, Maximilian Ruge, Simone Marnitz, Roland Goldbrunner, Martin Kocher
PURPOSE: Evaluation of postoperative fractionated local 3D-conformal radiotherapy (3DRT) of the resection cavity in brain metastases. PATIENTS AND METHODS: Between 2011 and 2016, 57 patients underwent resection of a single, previously untreated (37/57, 65%) or recurrent (20/57, 35%) brain metastasis (median maximal diameter 3.5 cm [1.1-6.5 cm]) followed by 3DRT. For definition of the gross tumor volume (GTV), the resection cavity was used and for the clinical target volume (CTV), margins of 1...
September 14, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Ahmad Tarhini, Sameer R Ghate, Raluca Ionescu-Ittu, Ameur M Manceur, Briana Ndife, Philippe Jacques, François Laliberté, Antonio Nakasato, Rebecca Burne, Mei Sheng Duh
Surgery is the mainstay treatment for operable nonmetastatic melanoma, but recurrences are common and limit patients' survival. This study aimed to describe real-world patterns of treatment and recurrence in patients with melanoma and to quantify healthcare resource utilization (HRU) and costs associated with episodes of locoregional/distant recurrences. Adults with nonmetastatic melanoma who underwent melanoma lymph node surgery were identified from the Truven Health MarketScan database (1 January 2008 to 31 July 2017)...
September 13, 2018: Melanoma Research
Sotirios Apostolakis, Athanasios Mitropoulos, Kalliopi Diamantopoulou, Konstantinos Vlachos
Background: Cavernomas are benign malformations of the vasculature. In the central nervous system, they are mostly located supratentorially. However, in adults, cavernomas also comprise about 3% of all subdural spinal cord tumors. Notably, cavernomas of the cauda equina are extremely rare, with only 23 cases reported in the literature. Here, we report the 24th case involving a 77-year-old male. Case Description: A 77-year-old male presented with low back pain for 3 years duration...
2018: Surgical Neurology International
Soodabeh Abbasi Sani, Mohammad Mahdi Forghanifard, Noorieh Sharifi, Mahnaz Hashemi Bidokhti, Alireza Jian Bagherpoor, Mohammad Reza Abbaszadegan
Background: Esophageal squamous cell carcinoma (ESCC) is considered as the seventh most common cancer worldwide, and the second prevalent malignancy in the north of Iran. A subfamily group of tumor-specific antigens, commonly specified as cancer/testis antigens (CTAs), are expressed restrictedly in testis, ovary, and placenta. Melanoma-associated antigen A4 (MAGEA4) as a CTA is overexpressed in a variety of cancers. Expressional analysis of MAGEA4 protein in ESCC may be useful to investigate its clinical relevance leading to effective improvements in ESCC diagnosis and treatment...
July 2018: Journal of Cancer Research and Therapeutics
T P Hanna, P Nguyen, T Baetz, C M Booth, E Eisenhauer
AIMS: New targeted drugs and immune therapies reported since 2010 for metastatic or unresectable melanoma (MM) have shown improved survival in randomised trials. We studied the uptake of these new drugs and their impact on population-based survival. MATERIALS AND METHODS: This was a retrospective, population-based cohort study of all patients treated for MM in Ontario 2007-2015. Provincial administrative sources covering the whole population identified palliative systemic therapy, radiotherapy and metastasis surgery...
October 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
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