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Sarcomas radiotherapy

Min Wook Joo, Yong Koo Kang, Koichi Ogura, Shintaro Iwata, June Hyuk Kim, Won Ju Jeong, Xiaohui Niu, Pramod S Chinder, Han Soo Kim, Sung Wook Seo, Yang-Guk Chung
The oncologic risk of ionizing radiation is widely known. Sarcomas developing after radiotherapy have been reported, and they are a growing problem because rapid advancements in cancer management and screening have increased the number of long-term survivors. Although many patients have undergone radiation treatment in Asian countries, scarce reports on post-radiation sarcomas (PRSs) have been published. We investigated the feature and prognostic factors of PRSs in an Asian population. The Eastern Asian Musculoskeletal Oncology Group participated in this project...
2018: PloS One
Hyun Ju Kim, Woong Sub Koom, Jaeho Cho, Hyo Song Kim, Chang Ok Suh
PURPOSE: Local recurrence is the most common cause of failure in retroperitoneal soft tissue sarcoma patients after surgical resection. Postoperative radiotherapy (PORT) is infrequently used due to its high complication risk. We investigated the efficacy of PORT using modern techniques in patients with retroperitoneal soft tissue sarcoma. MATERIALS AND METHODS: Eighty patients, who underwent surgical resection for non-metastatic primary retroperitoneal soft tissue sarcoma at the Yonsei Cancer Center between 1994 and 2015, were retrospectively reviewed...
November 2018: Yonsei Medical Journal
Dóra Mihály, Noémi Nagy, Gergő Papp, Zsuzsanna Pápai, Zoltán Sápi
BACKGROUND: Synovial sarcoma is a rare soft tissue tumor which contains the unique SS18-SSX1, SS18-SSX2 - or, rarely, SS18-SSX4 - fusion transcripts. It is well known that some soft tissue tumors, like Ewing sarcomas and myxoid liposarcomas, can spread via the blood with free circulating tumor cells (CTC); this can be detected by several sensitive molecular biology methods. Here we report a study of fifteen synovial sarcoma patients with varied clinical backgrounds. METHOD: After blood withdrawal and nucleic acid isolation, we attempted to detect the SS18-SSX fusion genes from circulating tumor cells or cell-free nucleic acids with nested PCR and droplet digital PCR...
October 17, 2018: Diagnostic Pathology
Uwe A Ulrich, Dominik Denschlag
Uterine adenosarcoma is a rare malignancy. It is defined as a biphasic tumor composed of both sarcomatous stroma and benign epithelium. While the sarcomatous component usually is a low-grade homologous uterine sarcoma, the epithelium most often consists of endometrium-like cells. If the sarcomatous part occupies more than 25% of the tumor volume, the situation is referred to as sarcomatous overgrowth - accounting for about 10% of cases. While adenosarcoma usually may be considered a tumor of low malignant potential, the sarcomatous overgrowth most often presents as high-grade sarcoma and is associated with aggressive clinical behavior...
October 17, 2018: Oncology Research and Treatment
Hafsa Chahdi, Bouchaib Chafry, Mohamed Allaoui
BACKGROUND: The extraskeletal myxoid chondrosarcoma (CME) is a rare tumor of the soft tissue, with clinically distinguishable clinical, histological, immunohistochemical, cytogenetic and evolutionary characteristics with an unfavorable long-term prognosis. CASE: We reported the case of a young patient of 18 years, accusing pelvic pain for 5 months with a poor general condition, an MRI was performed immediately, objective infiltrative mass endopelvic evoking several etiologies...
January 2018: La Tunisie Médicale
Panagiotis Tsagozis, Otte Brosjö, Mikael Skorpil
Background: Preoperative radiotherapy is often used to facilitate excision of soft-tissue sarcomas. We aimed define factors that affect local tumour control and patient survival. Methods: A single institution registry study of 89 patients with non-metastatic soft-tissue sarcomas having preoperative radiotherapy between 1994 and 2014. Radiologic (presence of peritumoural oedema and volume change following radiotherapy) and histopathologic (tumour volume, grade and surgical margin) parameters were recorded...
2018: Clinical Sarcoma Research
Jin-Hu Wang, Min-Ju Li, Da-Xing Tang, Shan Xu, Jun-Qing Mao, Jia-Bin Cai, Min He, Qiang Shu, Can Lai
BACKGROUND: Clear cell sarcoma of the kidney (CCSK) is a rare and aggressive malignant renal tumor. We describe our experience with neoadjuvant transcatheter arterial chemoembolization (TACE) and systematic chemotherapy for the treatment of advanced CCSK in children. METHODS: Between January 2010 and December 2016, seven patients (3 boys and 4 girls; median 2.2 years) with advanced CCSK received preoperative TACE of renal artery and systemic chemotherapy. The chemoembolic emulsion for TACE consisted of cisplatin, pirarubicin, vindesine, and iodized oil...
October 2, 2018: Journal of Pediatric Surgery
Emily Z Keung, Yi-Ju Chiang, Janice N Cormier, Keila E Torres, Kelly K Hunt, Barry W Feig, Christina L Roland
BACKGROUND: Retroperitoneal sarcomas (RPS) are rare tumors for which complete surgical resection remains the mainstay of treatment. The objective of the current study was to determine the impact of hospital case volume on outcomes in patients with RPS. METHODS: A total of 6950 patients with primary RPS who underwent surgical resection were identified from the National Cancer Data Base (1998-2011). Treating hospitals were classified by annual case volume; low-volume hospitals (LVHs) and high-volume hospitals (HVHs) were defined as those with ≤10 cases per year and >10 cases per year, respectively...
October 14, 2018: Cancer
Falk C Thiel, Sonja Halmen
Like other uterine sarcomas, low-grade endometrial stromal sarcomas (LG-ESS) are a very rare tumor entity. In the past, research studies therefore discussed the various different types of the disease in combination. In addition, the classification of endometrial stromal tumors presented difficulties for quite some time so that in earlier studies it was not always possible to precisely distinguish between LG-ESS, high-grade endometrial stromal sarcoma, and undifferentiated uterine sarcoma. For LG-ESS, surgery with hysterectomy and adnexectomy is the first-line treatment...
October 13, 2018: Oncology Research and Treatment
Jules Lansu, Jan Groenewegen, Frits van Coevorden, Winan van Houdt, Alexander C J van Akkooi, Hester van Boven, Michiel van de Sande, Marcel Verheij, Rick L Haas
AIMS: The purpose of the study was to investigate the time dependent dynamics of wound complications and local control after preoperative radiotherapy (RT) in Extremity Soft Tissue Sarcomas (ESTS). PATIENTS & METHODS: In this retrospective cohort study, all patients treated for an extremity sarcoma with pre-operative radiotherapy followed by surgery were identified from a prospectively maintained database. A wound complication (WC) was defined as any local complication of the surgical area requiring intervention, hospital readmission or significant extension of the initial admission period...
October 6, 2018: European Journal of Surgical Oncology
Yoshinobu Saitoh, Costansia Bureta, Hiromi Sasaki, Satoshi Nagano, Shingo Maeda, Tatsuhiko Furukawa, Noboru Taniguchi, Takao Setoguchi
Undifferentiated pleomorphic sarcoma (UPS) is the second most frequent soft tissue sarcoma. Because of its resistance to chemotherapy, UPS patients are treated with surgical resection and complementary radiotherapy. However, since standard chemotherapy has not been established, unresectable or metastatic cases result in a poor prognosis. Therefore, the identification of a more effective therapy for UPS patients is needed. The development and progression of malignant tumors involve epigenetic alterations, and histone deacetylases (HDAC) have become a promising chemotherapeutic target...
October 10, 2018: Molecular Carcinogenesis
Sebastian Zschaeck, Peter Wust, Ingo Melcher, Jacek Nadobny, Daniel Rau, Jana Striefler, Stefan Pahl, Anne Flörcken, Annegret Kunitz, Pirus Ghadjar
PURPOSE: Localized adult high-grade soft tissue sarcomas (STS) usually require multimodality treatment including surgery, radiotherapy, chemotherapy and hyperthermia. If maximal preoperative tumor-shrinkage is envisaged, neoadjuvant chemotherapy + radiation (CRT) is often applied, however at the expense of relatively high toxicities and increased postoperative complication rates. This study aims to compare preoperative CRT with neoadjuvant chemotherapy + regional hyperthermia (HCT) regarding histopathological response, toxicity and outcome...
October 9, 2018: International Journal of Hyperthermia
Raphaël Porcher, Justine Jacot, Jay S Wunder, David J Biau
Individualizing treatment according to patients' characteristics is central for personalized or precision medicine. There has been considerable recent research in developing statistical methods to determine optimal personalized treatment strategies by modeling the outcome of patients according to relevant covariates under each of the alternative treatments, and then relying on so-called predicted individual treatment effects. In this paper, we use potential outcomes and principal stratification frameworks and develop a multinomial model for left and right-censored data to estimate the probability that a patient is a responder given a set of baseline covariates...
October 9, 2018: Statistical Methods in Medical Research
R L Haas, J Szkandera
No abstract text is available yet for this article.
October 8, 2018: Annals of Surgical Oncology
Mahmoud Abdelnaby, Abdallah Almaghraby, Yehia Saleh, Rasha Abayazeed
Pericardial sarcomas are extremely rare aggressive neoplasms. Non-specific symptoms and incidental discovery are usually the rule. Multimodality imaging is extremely important for diagnosis and tissue characterisation of all cardiac masses. Despite treatment, pericardial sarcomas are considered extremely fatal. We encountered a 27-year-old female patient who presented to our facility with progressive dyspnoea. On examination, clinical signs of cardiac tamponade were appreciated, transthoracic echocardiography revealed a tamponading pericardial effusion and a large heterogeneous pericardial mass...
October 7, 2018: BMJ Case Reports
A Italiano, Solène Bringer, J Y Blay, S Bonvalot, A Le Cesne, F Le Loarer, P Maingon
More than half of all cancer patients receive radiotherapy. With the increasing number of long-term cancer survivors, there is a growing concern about the risk of radiation induced second malignant neoplasm. Sarcomas represent the most frequent type of cancer than can be induced by radiation exposure. We report the largest series of radiation-induced sarcomas (RIS). We demonstrate that a majority of RIS can be cured, provided they underwent well-planned surgery.
October 5, 2018: International Journal of Radiation Oncology, Biology, Physics
Hisaki Aiba, Satoshi Yamada, Jun Mizutani, Norio Yamamoto, Hideki Okamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Hiroyuki Tsuchiya, Takanobu Otsuka
BACKGROUND: Recurrence after wide excision or residual tumor after an unplanned excision of a malignant soft tissue sarcoma (STS) is a complex problem, due to a higher recurrence rate and poorer survival rate compared with primary resection. Regional hyperthermia was used, with the expectation that it will enhance the anti-tumor effects of chemotherapy and radiotherapy. This study aimed to assess the efficacy of neoadjuvant concomitant radiotherapy, hyperthermia, and chemotherapy (RHC) for salvage of recurrent or residual malignant STS...
October 8, 2018: International Journal of Hyperthermia
Elahe Nazeri, Mohammad Gouran Savadkoohi, Keivan Majidzadeh-A, Rezvan Esmaeili
Sarcomas are known as a heterogeneous class of cancers arisen in the connective tissues and demonstrated various histological subtypes including both soft tissue and bone origin. Chondrosarcoma is one of the main types of bone sarcoma that shows a considerable deficiency in response to chemotherapy and radiotherapy. While conventional treatment based on surgery, chemo-and radiotherapy are used in this tumor, high rate of death especially among children and adolescents are reported. Due to high resistance to current conventional therapies in chondrosarcoma, there is an urgent requirement to recognize factors causing resistance and discover new strategies for optimal treatment...
November 2018: Critical Reviews in Oncology/hematology
Hayden A Snow, Tatiana X Hitchen, Jessica Head, Alan Herschtal, Susie Bae, Sarat Chander, Julie Chu, Shona Hendry, Samuel Y Ngan, Jayesh Desai, Peter F M Choong, Michael Henderson, David E Gyorki
BACKGROUND: Several unanswered questions surround the management of retroperitoneal sarcoma (RPS). Guidelines recommend treatment by a multidisciplinary team at a specialized referral centre. The objective of this study was to describe the management of RPS at an Australian specialist sarcoma centre, comparing outcomes to international standards and analysing for predictors of local failure. METHODS: A retrospective review of a prospectively maintained database was performed on patients with RPS treated between 2008 and 2016...
October 4, 2018: ANZ Journal of Surgery
Jörg Thomas Hartmann
Soft tissue sarcomas are a diagnostically and therapeutically complex disease. This is due to the pronounced heterogeneity, characterized by biologically very different histological subtypes and the resulting clinical progressions. The term encompasses more than 80 different pathologically defined tumors of the soft tissue. Every year, nearly 4000 patients are affected in Germany. The diversity and rarity of the disease make progress difficult. The average 5-year mortality is around 40 %. Therapy is stage-adapted based on size, grading, localization, involvement of lymph nodes or distant metastasis...
October 2018: Deutsche Medizinische Wochenschrift
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