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Sarcomas radiotherapy

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https://www.readbyqxmd.com/read/30554419/is-malnutrition-associated-with-postoperative-complications-in-patients-with-primary-bone-sarcomas
#1
Andrew Park, Jonathan Lans, Kevin Raskin, Francis Hornicek, Joseph Schwab, Santiago Lozano Calderon
BACKGROUND: Modifiable risk factors that can be optimized to minimize postoperative complications in patients with bone sarcomas are yet to be identified. METHODS: We retrospectively identified 275 patients aged 18 and older who underwent surgery for primary bone sarcomas who also had albumin values recorded within 4 weeks before surgery. Postoperative complications were defined as infection, hematoma, need for additional surgery, or wound complications. RESULTS: In the multivariate analysis, age (P = 0...
December 16, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30553605/colonic-ewing-sarcoma-pnet-associated-with-liver-metastases-a-systematic-review-and-case-report
#2
Pietro Parcesepe, Guido Giordano, Caterina Zanella, Jacopo Giuliani, Filippo Greco, Andrea Bonetti, Massimo Pancione, Erminia Manfrin, Enrico Molinari, Tiziana Pia Latiano, Mario Rosario D'Andrea, Matteo Fassan, Nunzio Olivieri, Andrea Remo
Ewing Sarcoma is a highly lethal undifferentiated tumor of bone. ES is a small round cell tumor with etiological and characteristic chromosomal translocations between TET/FET (TLS/FUS, EWSR1, and TAF15) and ETS (E26 transformation-specific) family genes. Generally, therapeutic approach for metastatic Ewing Sarcoma includes both local (surgery and radiotherapy) and systemic (chemotherapy) disease control with an overall cure rate of 20%. For extra-osseous tumors, the most common primary sites of disease are trunk, extremities, head and neck, retroperitoneum...
November 29, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/30546886/radiotherapy-associated-intra-abdominal-angiosarcoma-after-prostatic-adenocarcinoma-case-reports
#3
David Parada Domínguez, Karla B Peña Gonzalez
Angiosarcoma is a rare soft tissue neoplasm, which accounts for <1% of all soft tissue tumours. It has been previously reported that the incidence rate of angiosarcomas increases following radiotherapy. The present study reports two cases of intra-abdominal angiosarcoma associated with previous radiotherapy treatment. To the best of our knowledge, these associations have not been previously described in English literature. The patients aged 71 and 83 years were admitted to the center for abdominal pain and diarrhea...
December 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30541578/proton-beam-therapy-for-cancer-in-the-era-of-precision-medicine
#4
REVIEW
Man Hu, Liyang Jiang, Xiangli Cui, Jianguang Zhang, Jinming Yu
Precision radiotherapy, which accurately delivers the dose on a tumor and confers little or no irradiation to the surrounding normal tissue and organs, results in maximum tumor control and decreases the toxicity to the utmost extent. Proton beam therapy (PBT) provides superior dose distributions and has a dosimetric advantage over photon beam therapy. Initially, the clinical practice and study of proton beam therapy focused on ocular tumor, skull base, paraspinal tumors (chondrosarcoma and chordoma), and unresectable sarcomas, which responded poorly when treated with photon radiotherapy...
December 12, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/30540864/-treatment-results-of-pediatric-soft-tissue-sarcomas-at-the-2nd-department-of-pediatrics-semmelweis-university
#5
Bianka Bots, Olivér Eipel, Lotte Terkovics, Luca Felkai, Monika Csóka
Malignant tumors found in children are different from the ones that occur in adults. Compared to the malignancies in adults, the histological entities in pediatric patients are different and survival rates are higher among the children. Though pediatric soft tissue sarcomas are less common than leukemia and central nervous system malignancies, recognition of them is necessary to start the therapy as soon as possible. The delay of an appropriate treatment - chemotherapy, radiotherapy, surgery, in some cases targeted therapy - is unfavorable because somatic damages and functional loss can occur...
December 12, 2018: Magyar Onkologia
https://www.readbyqxmd.com/read/30538385/resection-of-the-inferior-vena-cava-for-retroperitoneal-sarcoma-six-cases-and-a-review-of-literature
#6
Joy Ghose, Rahul Bhamre, Nikhil Mehta, Ashwin Desouza, Shraddha Patkar, Jayesh Dhareshwar, Mahesh Goel, Shailesh V Shrikhande
Resection of the inferior vena cava (IVC) for malignancy is a technically demanding procedure. We present a series of six cases of resection of the IVC for retroperitoneal sarcomas, four of which were primary caval tumors. We outline the technical difficulties faced in these complex procedures and discuss the oncological outcomes of these rare tumors. We performed a retrospective review of six patients operated for retroperitoneal masses involving the inferior vena cava between April 2015 and July 2016 at our tertiary care institute...
December 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30531222/proton-beam-therapy-in-pediatric-oncology
#7
Sujith Baliga, Torunn I Yock
PURPOSE OF REVIEW: The advent of proton beam therapy (PBT) has initiated a paradigm shift in the field of pediatric radiation oncology, with increasing promise to alleviate both short-term and long-term toxicities. Given the dramatic rise in proton therapy centers in the United States, a discussion of the quality of evidence supporting its use in pediatric cancers is warranted. RECENT FINDINGS: Proton radiotherapy appears to decrease the incidence and severity of late effects with the strongest evidence in pediatric brain tumor cohorts that shows benefits in neurocognitive, hearing, and endocrine outcomes...
December 6, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/30528284/propeller-flap-reconstruction-of-irradiated-sarcoma-defects-a-comparison-%C3%A2
#8
Sarah Lonie, Damien Grinsell, Eldon Mah
INTRODUCTION: The treatment for soft tissue sarcomas has evolved to include radiotherapy, wide local excision and plastic surgical reconstruction. Goals for the reconstruction of these irradiated defects are the introduction of non-irradiated healthy tissue, tension-free closure and obliteration of potential dead space. Although many defects once required free tissue transfer for reconstruction, greater knowledge of anatomical vascular pattern has led to the increasing use of propeller perforator flaps, islanded and transposed into the defect...
November 9, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/30527301/mri-assessment-of-surrounding-tissues-in-soft-tissue-sarcoma-during-neoadjuvant-chemotherapy-can-help-predicting-response-and-prognosis
#9
Amandine Crombé, François Le Loarer, Eberhard Stoeckle, Sophie Cousin, Audrey Michot, Antoine Italiano, Xavier Buy, Michèle Kind
OBJECTIVES: To determine if changes in surrounding tissues of soft-tissue sarcomas (STS) evaluated by MRI during neoadjuvant chemotherapy (NAC) are associated with the histological response and satellite tumorous cells beyond the pseudocapsule on surgical specimen, disease-free survival (DFS) and overall survival (OS). METHODS: Fifty-seven adult patients with locally advanced high-grade STS of extremities and trunk wall were included in this single-centre retrospective study...
December 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/30505419/analysis-of-postural-stability-and-daily-energy-expenditure-to-manage-tumor-patients-functional-expectation
#10
Emrah Caliskan, Evrim Karadag Saygi, Zeynep Kardelen Gencer, Hizir Kurtel, Bulent Erol
Background: Advances in surgical techniques, implant technology, radiotherapy, and chemotherapy have increased the recovery chances of patients with bone sarcomas. Accordingly, patients' expectations on life quality have also increased, highlighting the importance of objective evaluation of the functional results of reconstruction. Methods: Thirteen patients with distal femoral endoprosthesis, who had been followed for an average of 2.9 years were evaluated. Postural stability, daily energy expenditure, muscle power, and range of motion were the four parameters analyzed in this study...
December 2018: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/30496933/clinical-features-and-long-term-outcome-of-primary-intracranial-ewing-sarcoma-peripheral-primitive-neuroectodermal-tumors-14-cases-from-a-single-institution
#11
Jun Chen, Qian Jiang, Yu Zhang, Yufei Yu, Yifeng Zheng, Juan Chen, Yiqing Zhao, Zhuangzhuang Miao, Fanfan Fan, Yu Wang
OBJECTIVE: Primary intracranial Ewing sarcoma (ES)/peripheral primitive neuroectodermal tumors (pPNETs) are extremely rare, and only a few studies have reported more than four cases of this disease. The purpose of this study was to explore the clinical features, treatment, and outcome of primary intracranial ES/pPNETs. METHODS: The clinical data of 14 patients who had been surgically treated from February 2003 to November 2017 and in whom immunohistochemical staining results had confirmed the diagnosis of primary intracranial ES/pPNETs were retrospectively analyzed...
November 26, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30482506/laryngeal-synovial-sarcoma-report-of-2-cases
#12
Mouna Bellakhdhar, Amira Cheniti, Monia Ghammem, Ahlem Bdioui, Sarra Mestiri, Abir Meherzi, Wassim Kermani, Mohamed Abdelkefi
Synovial sarcoma is a malignant mesenchymal tumor. It most commonly occurs in the lower extremities of young adults. The head and neck are rare sites, accounting for less than 10%. The larynx is an extremely rare site. We report two cases of 27 and 18 year-old men who developed a synovial sarcoma of the larynx. They presented with hoarseness of voice and hemoptysis. Endoscopy detected a mass in the supraglottic region. The biopsy concluded a synovial sarcoma. Immunohistochemistry conveyed diagnostic certainty...
November 24, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/30479620/interstitial-brachytherapy-in-soft-tissue-sarcoma-a-5-years-institutional-experience-with-cobalt-60-based-high-dose-rate-brachytherapy-system
#13
Kazi Sazzad Manir, Abhishek Basu, Krishnangshu B Choudhury, Swapnendu Basu, Koushik Ghosh, Subir Gangopadhyay
Purpose: Soft tissue sarcoma (STS) is rare but aggressive neoplasm. Interstitial brachytherapy (ISBT) alone or combined with external beam radiotherapy (EBRT) as post-operative treatment improves loco-regional (LRC) and distant control. Material and methods: Out of twenty-nine non-metastatic STS (lower limb 64%) patients (median age 37 yrs), treated with surgery and post-operative ISBT during February 2011 - December 2016, 27 patients with > 6 months follow-up were analyzed...
October 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/30470126/clear-cell-sarcoma-of-tendons-and-aponeuroses-in-the-right-genitofemoral-line-a-case-report
#14
R Adwan, P Prošvic, J Prošvicová, V Straka, B Herzig
INTRODUCTION: Our case report presents a rare occurrence of clear cell sarcoma in the genitofemoral line region that has not been described to date. CASE REPORT: A 57-year-old male patient with clear-cell sarcoma of tendons and aponeuroses is presented. The patient underwent a radical operation and adjuvant radiotherapy. CONCLUSION: The patient is still alive, in a good health condition, without local recurrence or generalised disease...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/30464895/primary-myeloid-sarcoma-of-the-breast-a-case-report-and-review-of-literature
#15
Wafaey Gomaa, Ayman Ghanim, Eman Emam, Khaled Bayoumi, Ahmad Ghanim
Myeloid sarcoma (MS) of the breast is uncommon. We report this case of a 29-year-old female presented with a breast lump that was diagnosed as hamartoma by radiology. The lump was removed surgically. Pathological examination revealed a malignant tumor composed of immature cells with eosinophilic cytoplasm and single or multiple nucleoli, diffusely infiltrating the mammary parenchyma and sparing a few ducts and lobules. Immunostaining revealed positivity for leukocytic common antigen, myeloperoxidase, and CD68, and focally positive for CD34 and CD117...
October 2018: Journal of microscopy and ultrastructure
https://www.readbyqxmd.com/read/30459282/the-hdac3-smarca4-mir-27a-axis-promotes-expression-of-the-pax3-foxo1-fusion-oncogene-in-rhabdomyosarcoma
#16
Narendra Bharathy, Noah E Berlow, Eric Wang, Jinu Abraham, Teagan P Settelmeyer, Jody E Hooper, Matthew N Svalina, Yoshihiro Ishikawa, Keith Zientek, Zia Bajwa, Martin W Goros, Brian S Hernandez, Johannes E Wolff, Michelle A Rudek, Linping Xu, Nicole M Anders, Ranadip Pal, Alexandria P Harrold, Angela M Davies, Arya Ashok, Darnell Bushby, Maria Mancini, Christopher Noakes, Neal C Goodwin, Peter Ordentlich, James Keck, Douglas S Hawkins, Erin R Rudzinski, Bishwanath Chatterjee, Hans Peter Bächinger, Frederic G Barr, Jennifer Liddle, Benjamin A Garcia, Atiya Mansoor, Theodore J Perkins, Christopher R Vakoc, Joel E Michalek, Charles Keller
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood with an unmet clinical need for decades. A single oncogenic fusion gene is associated with treatment resistance and a 40 to 45% decrease in overall survival. We previously showed that expression of this PAX3:FOXO1 fusion oncogene in alveolar RMS (aRMS) mediates tolerance to chemotherapy and radiotherapy and that the class I-specific histone deacetylase (HDAC) inhibitor entinostat reduces PAX3:FOXO1 protein abundance. Here, we established the antitumor efficacy of entinostat with chemotherapy in various preclinical cell and mouse models and found that HDAC3 inhibition was the primary mechanism of entinostat-induced suppression of PAX3:FOXO1 abundance...
November 20, 2018: Science Signaling
https://www.readbyqxmd.com/read/30454911/the-impact-of-postoperative-therapy-on-primary-cardiac-sarcoma
#17
Yufan Wu, Lynn Million, Everett J Moding, Gregory Scott, Mark Berry, Kristen N Ganjoo
OBJECTIVE: Primary cardiac sarcomas (PCS) are extremely rare, portend a very poor prognosis, and have limited outcomes data to direct management. This study evaluated the impact of postoperative chemotherapy and/or radiotherapy on survival for PCS. METHODS: A retrospective chart review was conducted of 12 patients diagnosed with and who underwent resection for PCS at a single institution between 2000 and 2016. Data were collected on patient/tumor characteristics and analyzed with respect to treatment and outcome using Kaplan-Meier methods...
December 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/30453392/demographics-stage-distribution-and-relative-roles-of-surgery-and-radiotherapy-on-survival-of-persons-with-primary-prostate-sarcomas
#18
Jonathan D Tward, Matthew M Poppe, Ying J Hitchcock, Brock O'Neil, Daniel J Albertson, Dennis C Shrieve
BACKGROUND: Primary prostate sarcomas (PPS) are rare. Outcomes for this cancer have not been well characterized. MATERIALS AND METHODS: Subjects with a PPS diagnosed between 1973 and 2014 were identified in the SEER database. Subjects were stratified by disease stage and types of therapies received. Disease-specific survival (DSS) and Overall survival (OS) was estimated by Kaplan-Meier analysis and cohorts were compared with a univariate and multivariable Cox regression...
November 19, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/30449071/ewing-s-sarcoma-of-the-head-and-neck-margins-are-not-just-for-surgeons
#19
Jebrane Bouaoud, Stephane Temam, Nathalie Cozic, Louise Galmiche-Rolland, Kahina Belhous, Frederic Kolb, Francois Bidault, Stephanie Bolle, Sarah Dumont, Valerie Laurence, Dominique Plantaz, Marie-Dominique Tabone, Perrine Marec-Berard, Quentin Quassemyar, Vincent Couloigner, Arnaud Picard, Anne Gomez-Brouchet, Marie-Cécile Le Deley, Céline Mahier-Ait Oukhatar, Natacha Kadlub, Nathalie Gaspar
BACKGROUND, METHODS: To describe the characteristics, treatments (systemic/local), and outcome (oncological/functional) of French patients with head and neck Ewing's sarcomas (HNES) registered in the Euro-Ewing 99 (EE99) database. Specific patient-level data were reviewed retrospective. RESULTS: Forty-seven HNES patients in the EE99 database had a median age of 11 years, 89% had bone tumors (skull 55%, mandible 21%, maxilla 11%), 89% had small tumors (<200 mL), and they were rarely metastatic (9%)...
November 17, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/30447405/substantial-volume-changes-and-plan-adaptations-during-preoperative-radiotherapy-in-extremity-soft-tissue-sarcoma-patients
#20
R L Haas, S van Beek, A Betgen, S Ali, C J Schneider, F Heres Diddens, A N Scholten, F Koetsveld, P Remeijer
INTRODUCTION: Many authors suggest that extremity soft tissue sarcomas (ESTS) do not change significantly in size during preoperative radiotherapy (RT). This conebeam CT study investigates the justification to deliver the entire course with one initial RT plan by observing anatomical changes during RT. METHODS: In 2015-2017, 99 ESTS patients were treated with either curative (n=80) or palliative intent (n=19) with a regimen of at least 6 fractions. CTV-to-PTV margin was 1cm...
November 14, 2018: Practical Radiation Oncology
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