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Sarcomas radiotherapy

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https://www.readbyqxmd.com/read/30101012/extraskeletal-osteosarcoma-in-right-neck-subcutaneous-tissue-a-case-report-of-an-extremely-rare-tumour
#1
Jin-Shan Zhang, Ge Wen, Yuan Liu, Zhao-Hong Wu, Gang-Dong Chen, Hao Wang, Tong-Chong Zhou
Extraskeletal osteosarcoma (ESOS) is a rare soft-tissue sarcoma that is treated with surgical resection, chemotherapy and radiotherapy; however, as it is now considered to be radiation resistance, it is associated with conflicting management principles and poor outcomes. A multimodality approach is currently used to treat ESOS, which entails the incorporation of multidrug chemotherapy and/or radiotherapy coupled with surgery to obtain the best outcome; however, there are many factors that influence the treatment effects and clinical outcomes of ESOS...
August 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30094099/impact-of-first-line-treatment-on-outcomes-of-ewing-sarcoma-of-the-spine
#2
Jianjun Zhang, Yujing Huang, Jing Lu, Aina He, Yan Zhou, Haiyan Hu, Zan Shen, Yuanjue Sun, Yang Yao
The optimal first-line treatment for primary Ewing sarcoma (ES) of the spine is unclear, especially when the patients present with acute neurological deficits. This study aimed to retrospectively analyze the effect of first-line treatment with surgery or chemotherapy on neurological and survival outcomes of ES of the spine. 39 patients treated between January 2005 and December 2016 were included in the present analysis. 29 (74.4%) presented with symptomatic spinal cord compression at diagnosis. 21 patients were submitted to primary surgery followed by chemotherapy and local radiotherapy, while 18 patients received induction chemotherapy before surgery and/or local radiotherapy...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30091959/intra-articular-epithelioid-sarcoma-of-the-knee-a-diagnostic-challenge
#3
Teresa Martins Rocha, Rui Costa, João Barroso, Alexandra Bernardo, Márcio Rodrigues, Catarina Meireles, Filipe Duarte, Alberto Vieira, Mariana Afonso
Epithelioid sarcoma is a rare mesenchymal neoplasm characterized by aggregates of epithelioid cells. Intra-articular occurrence is exceedingly rare with only few reports described in the literature. A 22 year-old man presented a progressive mechanical knee pain. Initially, the investigation revealed a non-infectious unspecific synovitis. The patient gradually presented increasing knee enlargement and functional impairment. Intra-articular nodular proliferation with bone invasion was later observed on magnetic resonance imaging reevaluation...
April 2018: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/30080131/vincristine-irinotecan-and-temozolomide-treatment-for-refractory-relapsed-pediatric-solid-tumors-a-single-center-experience
#4
Sema Büyükkapu Bay, Rejin Kebudi, Omer Görgün, Bülent Zülfikar, Emin Darendeliler, Fatma B Çakır
Background Although the survival of pediatric cancer has increased dramatically in the last decades, the survival of refractory, relapsed, and metastatic cases is still dismal. The combination of irinotecan and temozolomide has shown activity against refractory/relapsed pediatric solid tumors. Method Thirty-four children with refractory/relapsed solid tumors who had previously been heavily pretreated and who were given vincristine, irinotecan, and temozolomide as third- or further line chemotherapy during 2004-2015 were evaluated...
August 6, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/30078492/chest-wall-reconstruction-after-tumor-resection
#5
Gideon Sandler, Andrea Hayes-Jordan
Pediatric chest wall tumors are rare. Malignancies predominate of which sarcomas are the most common. Their resection and the subsequent reconstruction of the chest wall has been a surgical challenge since Dr. Frederick W. Parham published his first comprehensive account on the subject in 1898. Chest wall reconstruction is age, site and pathology dependent, must preserve long term function and cosmesis, must accommodate future growth and development, and must not be a hindrance to adjuvant radiotherapy. Bony reconstruction can be relatively simple or complex involving combinations of synthetic meshes, bioprosthetic materials, steel or titanium constructs, autografts, homografts and porcine or bovine xenografts...
June 2018: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/30077790/short-hypofractionated-radiotherapy-in-palliation-of-pediatric-malignancies-outcomes-and-toxicities
#6
Stanislav Lazarev, Brian H Kushner, Suzanne L Wolden
PURPOSE: Treatment strategies in palliation of pediatric cancer remain a significant challenge. In this study, we aimed to assess efficacy and safety of a short course of hypofractionated RT for metastatic, or recurrent childhood tumors. METHODS AND MATERIALS: A total of 104 lesions in 62 pediatric patients with metastatic or recurrent cancer were treated with a short hypofractionation schedule (>1 but ≤5 fractions; ≥3 Gy per fraction) between 2007 and 2017 in our institution...
August 2, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/30077697/clinicopathologic-features-and-clinical-outcome-differences-in-de-novo-versus-secondary-histiocytic-sarcomas-a-multi-institutional-experience-and-review-of-the-literature
#7
Devin R Broadwater, Joanna L Conant, David R Czuchlewski, Jordan M Hall, Shi Wei, Gene P Siegal, Deniz Peker
INTRODUCTION: Histiocytic sarcoma (HS) is a rare malignant neoplasm that can occur in patients with a history of treatment for hematologic or solid tumors. Because no optimal treatment has been defined and standardized, the treatment modalities used and outcomes reported have been highly variable. In the present study, 3 major institutions explored the clinicopathologic features of de novo and secondary HS. MATERIALS AND METHODS: After institutional review board approval, clinical, histopathologic, and immunophenotypic data were collected from patients with a diagnosis of HS and treated at the University of Alabama at Birmingham, University of New Mexico, or Brooke Army Medical Center from January 1, 2003 to December 31, 2016...
August 1, 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/30077520/synovial-sarcoma-do-children-do-better
#8
Maria Anna Smolle, Michael Parry, Lee Jeys, Seggy Abudu, Robert Grimer
OBJECTIVES: Synovial sarcoma, a distinct subtype of soft tissue sarcomas (STS), is typically found in young patients. Long history of symptoms and heterogeneous clinical presentation sometimes delays diagnosis. Children have been reported to have a better prognosis than adults in some series. The main emphasis of this study was to determine differences between children and adults and to investigate prognostic factors regarding cancer specific survival (CSS). METHODS: 248 patients treated between 1982 and 2014 at one department were included...
July 20, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30076069/human-mesenchymal-stromal-cells-do-not-promote-recurrence-of-soft-tissue-sarcomas-in-mouse-xenografts-after-radiation-and-surgery
#9
Paola A Filomeno, Kyung-Phil Kim, Nara Yoon, Iran Rashedi, Victor Dayan, Rita A Kandel, Xing-Hua Wang, Tania C Felizardo, Elliot Berinstein, Salomeh Jelveh, Andrea Filomeno, Jeffrey A Medin, Peter C Ferguson, Armand Keating
BACKGROUND: Mesenchymal stromal cells (MSCs) promote wound healing, including after radiotherapy (RT) and surgery. The use of MSCs in regenerative medicine in the context of malignancy, such as to enhance wound healing post-RT/surgery in patients with soft tissue sarcomas (STSs), requires safety validation. The aim of this study was to determine the effects of human MSCs on STS growth in vitro and local recurrence and metastasis in vivo. METHODS: Human primary STS and HT-1080 fibrosarcoma lines were transduced to express luciferase/eGFP (enhanced green fluorescent protein)...
July 31, 2018: Cytotherapy
https://www.readbyqxmd.com/read/30060202/the-influence-of-anatomic-location-on-outcomes-in-patients-with-localized-primary-soft-tissue-sarcoma
#10
Ruping Zhao, Xiaoli Yu, Yan Feng, Jian Wang, Yanjiao Mao, Wei Yin, Zhen Zhang, Xiaomao Guo, Shenglin Ma
Background: We hypothesized that survival varied significantly between retroperitoneal soft tissue sarcoma (STS) and extremity/trunk STS. This study explored the reasons for the different outcomes and identified patient characteristics for survival. Methods: This retrospective study identified 213 consecutive patients with localized primary STS from January 2002 to July 2013, including 47 retroperitoneal STS (22.1%) and 166 extremity/trunk STS (77.9%). Local failure-free survival (LFFS), distant metastasis-free survival (DMFS) and overall survival (OS) were constructed by the Kaplan-Meier method...
July 27, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30049393/50-years-ago-in-the-journal-of-pediatrics-treatment-of-ewing-sarcoma-with-concurrent-radiotherapy-and-chemotherapy
#11
Emily Heikamp
No abstract text is available yet for this article.
August 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30034663/a-huge-phyllodes-tumor-in-the-breast-a-case-report
#12
Ibrahim Altedlawi Albalawi
Phyllodes tumor is a benign breast cancer with a malignant potential. It is very rare in Saudi Arabia and also rare around the world. Malignant phyllodes tumors originate from the connective tissue of the breast, so they are histologically sarcomas. We report the largest phyllodes tumor ever seen in Saudi Arabia, a 41-year-old female who presented with a huge breast mass occupying the whole breast with areas of ulceration. Her history had started 14 months previously with a slowly growing left breast swelling, ultimately the lump ulcerated and became necrotic...
June 2018: Electronic Physician
https://www.readbyqxmd.com/read/30031154/correlation-between-rb1germline-mutations-and-second-primary-malignancies-in-hereditary-retinoblastoma-patients-treated-with-external-beam-radiotherapy
#13
REVIEW
Amélie Chaussade, Gaël Millot, Constance Wells, Hervé Brisse, Marick Laé, Alexia Savignoni, Laurence Desjardins, Rémi Dendale, François Doz, Isabelle Aerts, Irène Jimenez, Nathalie Cassoux, Dominique Stoppa Lyonnet, Marion Gauthier Villars, Claude Houdayer
Retinoblastoma (Rb) results from biallelic inactivation of the RB1 gene. Hereditary Rb patients i. e germline carriers of a RB1 mutation also have a risk of developing subsequent malignant neoplasms (SMN) such as osteosarcomas. This SMN risk is maximized by external beam radiotherapy treatments (EBRT), which is why these treatments are now avoided. Nevertheless, EBRT is still a matter of great concern, as EBRT-treated patients are in their adulthood and SMNs remain the major cause of death for patients. To decipher the relationship between RB1 genotype and SMN development in EBRT treated patients, we conducted a retrospective study in a cohort of 160 irradiated hereditary Rbs with fully resolved RB1 mutational status...
July 18, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/30030906/carbon-ion-radiotherapy-for-unresectable-localized-axial-soft-tissue-sarcoma
#14
Reiko Imai, Tadashi Kamada, Nobuhito Araki
Carbon ion radiotherapy is known for its high-precision dose distribution and high biological effectiveness. We evaluated the results of carbon ion radiotherapy in 128 patients with unresectable localized axial soft tissue sarcoma at a single institution. The patients' median age was 54 years, and the median follow-up period was 49.4 (range 6.4-146.4) months. The median tumor volume was 356 cm3 . The 5-year local control, overall survival, and disease-free survival rates were 65%, 46%, and 39%, respectively...
July 20, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/30030882/limb-sparing-surgery-plus-radiotherapy-results-in-superior-survival-an-analysis-of-patients-with-high-grade-extremity-soft-tissue-sarcoma-from-the-ncdb-and-seer
#15
Stephen J Ramey, Raphael Yechieli, Wei Zhao, Joyson Kodiyan, David Asher, Felix M Chinea, Vivek Patel, Isildinha M Reis, Lily Wang, Breelyn A Wilky, Ty Subhawong, Jonathan C Trent
Small randomized trials have not shown an overall survival (OS) difference among local treatment modalities for patients with extremity soft-tissue sarcomas (E-STS) but were underpowered for OS. We examine the impact of local treatment modalities on OS and sarcoma mortality (SM) using two national registries. The National Cancer Database (NCDB) and the Surveillance, Epidemiology, and End Results (SEER) Program were analyzed separately to identify patients with stage II-III, high-grade E-STS diagnosed between 2004 and 2013 and treated with (1) amputation alone, (2) limb-sparing surgery (LSS) alone, (3) preoperative radiation therapy (RT) and LSS, or (4) LSS and postoperative RT...
July 20, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/30028823/syncytial-variant-nodular-sclerosis-classical-hodgkin-lymphoma-in-an-adolescent-and-review-of-the-literature-a-unique-entity
#16
Eman Al-Antary, Rohith Jesudas, Amy George, Janet Poulik, Süreyya Savaşan
Syncytial variant of nodular sclerosis (SV-NS) classical Hodgkin lymphoma (cHL) with its histologic features and clinical presentation is uncommon in adults and extremely rare in children. Here, we report a female teenager presenting with long-standing B symptoms, prominent soft tissue and bone involvement mimicking sarcoma and significant nodal disease who is diagnosed with advanced SV-NS cHL. Rare Reed-Sternberg-like cells displaying neutrophil and erythrocyte emperipolesis were seen on bone marrow aspiration slides...
July 19, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30027013/acquired-hemophilia-secondary-to-soft-tissue-sarcoma-case-report-from-a-latin-american-hospital-and-literature-review
#17
Camila Casadiego-Peña, Alejandro González-Motta, Oliver G Perilla, Pedro D Gomez, Leonardo J Enciso
Acquired hemophilia A is a rare bleeding disorder caused by inhibiting antibodies against factor VIII characterized by the presence of severe bleeding, which in occasions can be lethal. The bleeding manifestations typically have a sudden onset and patients have a negative family and personal histories of bleeding, with a normal prothrombin time (PT) and an extended partial thromboplastin time (PTT). Incidence has been calculated to be between 0.2 and 1.48 cases per million per year. Between 6% and 15% of cases are associated with neoplasms...
May 14, 2018: Curēus
https://www.readbyqxmd.com/read/30002213/secondary-spindle-cell-sarcoma-following-external-beam-radiotherapy-for-prostate-cancer-a-rare-but-devastating-complication
#18
Matthew Farag, Anthony Ta, Siva Shankar, Lih-Ming Wong
We report a case of rapidly growing sarcoma that resulted in mortality only 6 years after radiotherapy for low-grade prostate cancer.At the age of 69 years and a prostate-specific antigen (PSA) that had risen to 9.0 µg/L, transrectal ultrasound-guided biopsy of the prostate found a single core of Gleason 3+3 disease involving 4 mm of a 10 mm core. The patient declined active surveillance and completed 78 Gy of external beam radiotherapy over 39 fractions to a prostate volume of 46 mL.His PSA nadir was 0...
July 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29989856/risk-of-solid-cancer-after-treatment-of-testicular-germ-cell-cancer-in-the-platinum-era
#19
Harmke J Groot, Sjoukje Lubberts, Ronald de Wit, Johannes A Witjes, Jan Martijn Kerst, Igle J de Jong, Gerard Groenewegen, Alfons J M van den Eertwegh, Philip M Poortmans, Heinz-Josef Klümpen, Hetty A van den Berg, Tineke J Smilde, Ben G L Vanneste, Maureen J Aarts, Luca Incrocci, Alfons C M van den Bergh, Katarzyna Jóźwiak, Alexandra W van den Belt-Dusebout, Simon Horenblas, Jourik A Gietema, Flora E van Leeuwen, Michael Schaapveld
Purpose Testicular cancer (TC) treatment increases risk of subsequent malignant neoplasms (SMNs). It is unknown whether changes in TC treatment over time have affected SMN risk. Methods Solid SMN risk was evaluated in a multicenter cohort comprising 5,848 1-year survivors treated for TC before age 50 years between 1976 and 2007. SMN incidence was compared with cancer incidence in the general population. Treatment-specific risks were assessed using multivariable regression in a case-cohort design. Results After a median follow-up of 14...
July 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29988594/regional-chemotherapy-by-isolated-limb-perfusion-prior-to-surgery-compared-with-surgery-and-post-operative-radiotherapy-for-primary-locally-advanced-extremity-sarcoma-a-comparison-of-matched-cohorts
#20
Jens Jakob, Henry G Smith, Michelle J Wilkinson, Tim Pencavel, Aisha B Miah, Joseph M Thomas, Per-Ulf Tunn, Lothar R Pilz, Dirk C Strauss, Peter Hohenberger, Andrew J Hayes
Background: Induction chemotherapy by isolated limb perfusion (ILP) with melphalan and tumour necrosis factor-α is an effective strategy to facilitate limb-conserving surgery in locally advanced extremity sarcoma. In a comparison of cohorts matched for grade, size and surgical resectability, we compared the outcome of patients undergoing induction ILP prior to limb-conserving surgery and selective post-operative radiotherapy with patients undergoing limb-conserving surgery and routine post-operative radiotherapy...
2018: Clinical Sarcoma Research
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