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eosinophilic diseases

Jenny Hallberg, Natalia Ballardini, Catarina Almqvist, Marit Westman, Marianne van Hage, Gunnar Lilja, Anna Bergström, Inger Kull, Erik Melén
BACKGROUND: Both allergic and non-allergic rhinitis are associated with worse asthma control. However, it is unclear how IgE sensitization and/or rhinitis are associated to lung function. We therefore evaluated the effect of rhinitis and sensitization on lung function, including the periphery of the airway system, and inflammatory biomarkers in individuals with and without asthma. METHODS: Participants in the BAMSE longitudinal birth cohort study underwent measures of spirometry, impulse oscillometry and FeNO at age 16 years...
October 20, 2018: Pediatric Allergy and Immunology
Matea Kovačić, Josipa Unić, Zrinjka Mišak, Oleg Jadrešin, Vlatka Konjik, Sanja Kolaček, Iva Hojsak
BACKGROUND AND AIMS: Despite rising incidence of eosinophilic esophagitis (EoE), data on the follow-up and treatment outcomes in pediatric patients are scarce. Therefore, the aim of this study was to present data on the treatment outcomes in children diagnosed with EoE who were treated in a tertiary medical center. PATIENTS AND METHODS: A retrospective study involving patients younger than 18 years who were diagnosed with EoE in our center between January 2011 and June 2017...
October 19, 2018: Esophagus: Official Journal of the Japan Esophageal Society
Zhu Chen, Aline Bozec, Andreas Ramming, Georg Schett
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a failure of spontaneous resolution of inflammation. Although the pro-inflammatory cytokines and mediators that trigger RA have been the focus of intense investigations, the regulatory and anti-inflammatory cytokines responsible for the suppression and resolution of disease in a context-dependent manner have been less well characterized. However, knowledge of the pathways that control the suppression and resolution of inflammation in RA is clinically relevant and conceptually important for understanding the pathophysiology of the disease and for the development of treatments that enable long-term remission...
October 19, 2018: Nature Reviews. Rheumatology
Marisol I Gonzalez, Fernando Lopes, Derek M McKay, Jose L Reyes
Infection with helminth parasites evokes a complex cellular response in the host, where granulocytes (i.e. eosinophils, basophils and mast cells (MCs)) feature prominently.  In addition to being used as markers of helminthic infections, MCs have been implicated in worm expulsion since animals defective in c-kit signalling, which results in diminished MC numbers, can have delayed worm expulsion. The role of MCs in the rejection of the rat tapeworm, Hymenolepsis diminuta , from the non-permissive mosue host is not known...
October 19, 2018: Bioscience Reports
Ewa Szczerba, Robert Kowalik, Katarzyna Gorska, Michal Mierzejewski, Anna Slowikowska, Tomasz Bednarczyk, Michal Marchel, Rafal Krenke, Grzegorz Opolski
We present a case of 44-year-old woman who underwent effective pharmacological treatment of severe mitral stenosis. The patient was hospitalized due to rapidly progressive dyspnea. Her medical history included asthma, perennial rhinitis, and nasal polyps. Echocardiography showed a mass of the left ventricle involving the mitral valve; cardiac MRI suggested acute endocarditis. Severe peripheral blood eosinophilia was found. Eosinophilic granulomatosis with polyangiitis was diagnosed; treatment with prednisone and cyclophosphamide was started...
October 18, 2018: Echocardiography
Borja G Cosío, David Dacal, Luis Pérez de Llano
Asthma and chronic obstructive pulmonary disease (COPD) are both highly prevalent conditions that can coexist in the same individual: the so-called 'asthma -COPD overlap' (ACO). Its prevalence and prognosis vary widely depending on how ACO is defined in each publication, the severity of bronchial obstruction of patients included and the treatment they are receiving. Although there is a lack of evidence about the biology of ACO, the overlap of both diseases should express a mixture of a Th1 inflammatory pattern (characteristic of COPD) and a Th2 signature (characteristic of asthma)...
January 2018: Therapeutic Advances in Respiratory Disease
Luc Biedermann, Alex Straumann
Eosinophilic esophagitis (EoE) refers to a relatively new chronic inflammatory disease of the esophagus, which according to the current understanding underlies an immune-mediated pathogenesis driven by exposure to allergens. While several open questions remain regarding ethiopathogenesis as well as treatment options and their positioning, one thing has increasingly been recognized. The disease is on the rise and will increasingly be of importance in everyday's clinical practice, not only in expert physicians but also gastroenterologists with a broad clinical spectrum, allergologists and even general practitioners...
October 15, 2018: Current Opinion in Pharmacology
Alexia D'Andréa, Damien L Peillet, Christine Serratrice, Pierre-Augute Petignat, Virginie Prendki, Jean-Luc Reny, Jacques Serratrice
RATIONALE: Eosinophilic pleural effusion in elderly patients is most commonly due to malignancies and infections. PATIENT CONCERNS: In rare cases, pleural eosinophilia is associated with connective tissue disease. DIAGNOSES: Presence of Hargraves cells, also called lupus erythematosus (LE) cells (polynuclear cells that have engulfed denatured nuclear material), was a key point of American College of Rheumatology (ACR) classification criteria for systemic lupus erythematosus (SLE) until 1997...
October 2018: Medicine (Baltimore)
Shohei Asada, Akitoshi Douhara, Koji Murata, Koji Yanase, Masahiro Tsutsumi, Hitoshi Yoshiji
Both autoimmune hepatitis (AIH) and eosinophilic fasciitis (EF) are known to be complicated by other autoimmune diseases. However, AIH complicated by EF has never been reported. We experienced a 58-year-old man with AIH complicated by EF. He was admitted to our hospital with acute hepatic injury and edema of the legs in April 201X. The etiologies of these symptoms were histologically proven as AIH and EF. The administration of prednisolone (PSL) drastically improved his liver injury and edema of the legs. When we make a diagnosis of AIH, we should carefully evaluate the physical findings, including the appearance of the legs, in order to detect other coexisting autoimmune diseases...
October 17, 2018: Internal Medicine
Haris Zahoor, Pedro C Barata, Xuefei Jia, Allison Martin, Kimberly D Allman, Laura S Wood, Timothy D Gilligan, Petros Grivas, Moshe C Ornstein, Jorge A Garcia, Brian I Rini
BACKGROUND: Nivolumab is approved for the treatment of refractory metastatic renal cell carcinoma. Patterns and predictors of progressive disease (PD) on nivolumab, and outcomes in such patients are lacking. METHODS: A retrospective analysis of patients (pts) with metastatic clear cell renal cell carcinoma (ccRCC) who received nivolumab at Cleveland Clinic (2015-2017) was performed. PD was defined per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 or clinical progression as per treating physician...
October 17, 2018: Journal for Immunotherapy of Cancer
Soichiro Ueda, Koichi Fukunaga, Takahisa Takihara, Yoshiki Shiraishi, Tsuyoshi Oguma, Tetsuya Shiomi, Yusuke Suzuki, Makoto Ishii, Koichi Sayama, Shizuko Kagawa, Hiroyuki Hirai, Kinya Nagata, Masataka Nakamura, Taku Miyasho, Tomoko Betsuyaku, Koichiro Asano
Chemoattractant receptor homologous with Th2 cells (CRTH2), a receptor for prostaglandin D2 is preferentially expressed on Th2 lymphocytes, group 2 innate lymphoid cells, eosinophils, and basophils, and elicits production of type2 cytokines including profibrotic IL-13. We supposed lack of CRTH2 might be protective role against fibrotic lung disease and examined bleomycin-induced lung inflammation and fibrosis model with CRTH2-deficient (CRTH2-/-) or wild-type BALB/c mice. Compared to the wild-type, CRTH2-/- mice treated with bleomycin exhibited significantly higher mortality, enhanced accumulation of inflammatory cells 14-21 days after bleomycin injection, reduced pulmonary compliance, and increased levels of collagen and total protein in the lungs...
October 16, 2018: American Journal of Respiratory Cell and Molecular Biology
Murat Türk, Sakine Nazik Bahçecioğlu, Nuri Tutar, Fatma Sema Oymak, İnci Gülmez, İnsu Yılmaz
OBJECTIVES: Omalizumab is a monoclonal antibody that is used as add-on therapy for treating moderate-to-severe persistant atopic asthma in patients with persistant symptoms and frequent exacerbations, despite step 4 treatment according to GINA guidelines. Real-life studies on omalizumab treatment are limited in Turkey. Thus, the present study aims to assess the clinical efficacy and treatment outcomes of omalizumab in patients with atopic severe persistant asthma. MATERIALS AND METHODS: Patients with atopic severe persistant asthma who were treated with omalizumab between 2009 and 2017 were retrospectively evaluated...
September 13, 2018: Turkish Thoracic Journal
Emine Aksoy, Sinem Güngör, Meltem Çoban Ağca, İpek Özmen, Dildar Duman, Nagihan Durmuş Koçak, Ülkü Aka Aktürk, Eylem Tunçay, Cüneyt Saltürk, Murat Yalçınsoy, Birsen Ocaklı, Zuhal Karakurt
OBJECTIVES: The choice of treatment according to the inflammation type in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has been of recent interest. This study investigated the role of novel biomarkers, hospital outcomes, and readmission rates in the first month in patients with eosinophilic or neutrophilic AECOPD. MATERIALS AND METHODS: We conducted a retrospective observational cohort study in a Chest Teaching Hospital with hospitalized AECOPD patients...
September 13, 2018: Turkish Thoracic Journal
Tatyana Milman, Codrin Iacob, Simeon Lauer, Michael D Feldman, Paul J L Zhang
Neoplasms arising in accessory lacrimal glands are rare. We describe a 33-year-old man with adenocarcinoma arising in the left lower eyelid accessory lacrimal gland. Microscopic evaluation demonstrated an infiltrative neoplasm composed of mildly to moderately pleomorphic cells with abundant eosinophilic cytoplasm and focal intracytoplasmic vacuoles, arranged predominantly in ductules. Foci of luminal and intracytoplasmic eosinophilic secretory material and occasional mucin were noted. An in situ component was identified in the gland of Wolfring...
September 2018: Ocular Oncology and Pathology
Brian Lipworth, Chris RuiWen Kuo, Sunny Jabbal
A single inhaler containing inhaled corticosteroid (ICS)/long-acting beta-agonist (LABA)/long-acting muscarinic antagonist (LAMA) is a more convenient way of delivering triple therapy in patients with COPD. Single triple therapy has been shown to be superior at reducing exacerbations and improving quality of life compared to LABA/LAMA, especially in patients with a prior history of frequent exacerbations and blood eosinophilia, who have ICS responsive disease. The corollary is that patients with infrequent exacerbations who are noneosinophilic may be safely de-escalated from triple therapy to LABA/LAMA without loss of control...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Bailu Du, Yue Tao, Jing Ma, Xing Weng, Yanping Gong, Yang Lin, Nan Shen, Xi Mo, Qing Cao
The incidence of sparganosis, a parasitic disease caused by plerocercoid larvae of the genus Spirometra, has gradually risen worldwide (especially in remote areas) in recent years. Pulmonary and pleural sparganosis, as well as other sites of infestation, including the subcutaneous tissues, the abdominal viscera, brain and eyes, has been reported. In clinical practice, due to the atypical signs and symptoms and limited laboratory approaches for the specific detection of sparganum, sparganosis is often misdiagnosed...
October 10, 2018: Infection, Genetics and Evolution
Chrysanthi Skevaki, Harald Renz
This review highlights advances in mechanisms of allergic disease, particularly type 2 innate lymphoid cells; TH 2 lymphocytes; B cells; dendritic cells: microbiome and barrier function; eosinophils, mast cells. During the last year, considerable progress has been made in the further characterization of type 2 inflammation controlled by both adaptive (TH 2) as well as innate (ILC2) effector cells. New pathways of lymphocyte activation, trafficking and recruitment, and effector cell mechanisms have been discovered...
October 10, 2018: Journal of Allergy and Clinical Immunology
S M Jalali, A Rasooli, M Seifi Abad Shapuri, M Daneshi
This study was performed to determine the clinical, hematologic, and biochemical findings in animals affected with lumpy skin disease (LSD) in southwest Iran. Sixty cattle with LSD were included in this study and compared with 20 healthy ones as the control group. The disease was diagnosed based on clinical examination and confirmed by polymerase chain reaction analysis of the blood samples. The major observed clinical signs included skin nodules, fever, enlarged lymph nodes, and edema. In hematologic assessment, the average numbers of leukocytes, lymphocytes, eosinophils, erythrocytes, and platelets, as well as the average level of hemoglobin in the infected animals were significantly lower than in the control group...
December 2017: Archives of Razi Institute
Luc Dauchet, Sébastien Hulo, Nathalie Cherot-Kornobis, Régis Matran, Philippe Amouyel, Jean-Louis Edmé, Jonathan Giovannelli
INTRODUCTION: Air pollution impacts health by increasing mortality and the incidence of acute events in unhealthy individuals. In contrast, the acute effects of pollution in healthy individuals are less obvious. The present study was designed to evaluate the associations between short-term exposure to air pollution on one hand and lung function, and inflammatory markers on the other in middle-aged, non-smoking adults with no respiratory disease, in two urban areas in northern France. METHODS: A sample of 1506 non-smoking adults (aged from 40 to 65) with no respiratory disease was selected from the participants in the 2011-2013 cross-sectional Enquête Littoral Souffle Air Biologie Environnement (ELISABET) survey in two urban areas in the northern France...
October 9, 2018: Environment International
O L M Määttä, H P Laurila, S Holopainen, L Lilja-Maula, M Melamies, S J Viitanen, L R Johnson, N Koho, M Neuvonen, M Niemi, M M Rajamäki
BACKGROUND: Gastroesophageal reflux and microaspiration (MA) of gastric juice are associated with various human respiratory diseases but not in dogs. OBJECTIVE: To detect the presence of bile acids in bronchoalveolar lavage fluid (BALF) of dogs with various respiratory diseases. ANIMALS: Twenty-seven West Highland White Terriers (WHWTs) with canine idiopathic pulmonary fibrosis (CIPF), 11 dogs with bacterial pneumonia (BP), 13 with chronic bronchitis (CB), 9 with eosinophilic bronchopneumopathy (EBP), 19 with laryngeal dysfunction (LD), 8 Irish Wolfhounds (IWHs) with previous BPs, 13 healthy WHWTs, all privately owned dogs, and 6 healthy research colony Beagles METHODS: Prospective cross-sectional observational study with convenience sampling of dogs...
October 12, 2018: Journal of Veterinary Internal Medicine
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