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eosinophilic diseases

Heba Ahmed Osman, Sanaa S Aly, Hasan S Mahmoud, Eman H Ahmed, Eman M Salah Eldin, Eman A Abdelrahim, Muhammad A El Masry, Rania A Herdan, Mohammed H Hassan
BACKGROUND AND AIMS: Gastroesophageal reflux disease (GERD) is a common prevalent disease. We aimed to assess the dynamic changes in the peripheral T lymphocytes and lymphocytes infiltrating the esophageal mucosa after treatment with proton-pump inhibitor (PPI) in patients with GERD. PATIENTS AND METHODS: A total of 200 patients who presented with upper GIT symptoms were included in this prospective study. All patients were subjected to full history taking, clinical examination, and complete blood count...
August 16, 2018: Journal of Clinical Gastroenterology
Vanessa Fernandes Rodrigues, Márcia Paulliny Soares Bahia, Núbia Rangel Cândido, João Marcelo Peixoto Moreira, Vinicius Gustavo Oliveira, Emília Souza Araújo, Jailza Lima Rodrigues Oliveira, Michelle de Carvalho Rezende, Ary Correa, Deborah Negrão-Corrêa
Helminth infection can reduce the severity of inflammatory bowel disease. However, the modulatory mechanisms elicited by helminth infection are not yet fully understood and vary depending on the experimental model. Herein we evaluated the effect of acute infection of BALB/c mice with Strongyloides venezuelensis on the clinical course of ulcerative colitis induced by Dextran Sulfate Sodium (DSS) treatment of these animals. For the experiments, S. venezuelensis-infected BALB/c mice were treated orally with 4% DSS solution for seven days...
August 14, 2018: Cytokine
Hiroki Sato, Terasu Honma, Takashi Owaki, Kentaro Tominaga, Junji Yokoyama, Shuji Terai
BACKGROUND: Eosinophilic gastroenteritis (EoGE) can be diagnosed on the basis of histologic criteria; however, the pathology is considered to be heterogeneous. There is no consensus on the management of this enigmatic disorder with an unknown etiology. PATIENTS AND METHODS: Data for patients diagnosed with EoGE and followed up over a 1-year period were analyzed. Their symptoms, patterns of flares, and type of treatment were documented. The shift in peripheral blood eosinophil levels was also examined...
August 14, 2018: European Journal of Gastroenterology & Hepatology
Adrienne J Showler, Thomas B Nutman
PURPOSE OF REVIEW: With increasing international travel and mass global population migration, clinicians in nonendemic countries must be familiar with imported neglected tropical diseases including onchocerciasis, which is commonly known as 'river blindness'. RECENT FINDINGS: Imported onchocerciasis manifests differently in travelers compared with migrants from endemic areas and is likely underdiagnosed in both groups. Recent clinical studies confirm that eosinophilia is not a sensitive marker for Onchocerca volvulus, with one-third of patients having a normal eosinophil count...
August 14, 2018: Current Opinion in Infectious Diseases
Michael Guo, Fahad Alasousi, Christopher Okpaleke, Al-Rahim Habib, Amin Javer
Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have a high risk of disease recurrence and revision surgery. The ability to predict a polyp recurrence in this patient population is critical in order to provide adequately tailored postoperative management. Objective We aim to explore the role of appropriate postoperative care in the prognosis of CRSwNP patients in relation to preoperative eosinophil and basophils levels. Methods This was a retrospective case series; data were collected for 102 CRSwNP patients over a period of 15 months after surgery...
August 16, 2018: American Journal of Rhinology & Allergy
Tarun Dalia, Sonya Parashar, Nilay V Patel, Archana Gautam, Hongyan Dai, Steven Bormann
Eosinophilic granulomatosis with polyangiitis (EGPA), historically known as the Churg-Strauss disease, is a small- to medium-sized vessel multi-organ vasculitis with a propensity to involve the heart. EGPA is a rare condition with an estimated annual incidence of one to 4.2 people per million. The cardiac involvement causes significant morbidity and mortality in EGPA patients. Approximately 50% of the deaths in EGPA are related to cardiac disease and occur within the first few months since diagnosis. The current recommendations support evaluation of cardiac involvement by using history, physical exam and multimodality imaging including echocardiogram and cardiac magnetic resonance imaging (CMR)...
June 12, 2018: Curēus
Ronja Mathiesen, Julie Melsted Birch, Mariann Chriél, Henrik Elvang Jensen, Jens Frederik Agger, Peter Mikael Helweg Heegaard, Tina Struve
BACKGROUND: Pre-weaning diarrhea (PWD) is a syndrome affecting farm-raised neonatal mink kits. Apart from diarrhea it causes greasy skin exudation, dehydration, and distressed behavior and can ultimately lead to death. No specific causative agents have been identified and the syndrome is regarded as multifactorial. The aim of the present study was to investigate a possible inflammatory state in mink kits with PWD, as indicated by raised serum concentrations of the acute phase protein serum amyloid A (SAA) and by changes in intestinal pathomorphology and intestinal contents of bacteria...
August 15, 2018: Acta Veterinaria Scandinavica
Stephanie Posten, Tonya Adamiak, Melissa Jensen
Eosinophilic esophagitis (EoE) is a chronic immune-mediated esophageal inflammatory disease that is becoming more widely recognized as a cause of feeding difficulties in infants and young children, as well as gastroesophageal reflux disease (GERD)-like symptoms, dysphagia, and food impaction in children and adolescents. The diagnosis of EoE is clinicopathologic, based on endoscopic, histologic, and clinical findings. Patients with suspected eosinophilic esophagitis require an endoscopy with biopsies. The diagnosis requires the presence of 15 or more intraepithelial eosinophils/HPF in at least one endoscopic esophageal mucosal biopsy...
August 2018: South Dakota Medicine: the Journal of the South Dakota State Medical Association
M Zhao, A X Wang, X Zhu, J J Yu, W Wang, D H Zhang, X L He, H Y He, X D Teng
Objective: To investigate the clinicopathologic and differential diagnostic features of glomus tumor of the kidney. Methods: Four cases of glomus tumor of the kidney were collected from the archives of Peking University Third Hospital, the Second Hospital of Tianjin Medical University, Ningbo Yinzhou Second Hospital and Zhejiang Provincial People's Hospital between January 2012 to June 2017; the clinical and radiologic features, histomorphology, immunohistochemistry, ultrastucture and prognosis were analyzed and the relevant literature was reviewed...
August 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Yamini V Virkud, Rachel S Kelly, Damien C Croteau-Chonka, Juan C Celedón, Amber Dahlin, Lydiana Avila, Benjamin A Raby, Scott T Weiss, Jessica A Lasky-Su
BACKGROUND: Asthma represents a significant public health burden; however, novel biological therapies targeting immunoglobulin E (IgE)-mediated pathways have widened clinical treatment options for the disease. OBJECTIVE: In this study we sought to identify gene transcripts and gene networks involved in the determination of serum IgE levels in people with asthma that can help inform the development of novel therapeutic agents. METHODS: We analyzed gene expression data from a cross-sectional study of 326 Costa Rican children with asthma, aged 6 to 12 years, from the Genetics of Asthma in Costa Rica Study and 610 young adults with asthma, aged 16 to 25 years, from the Childhood Asthma Management Program trial...
August 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Ahmed A Al Sarkhy, Anjum Saeed, Yassin H Hamid, Mona M Al Asmi, Tariq I Altokhais, Anhar A Ullah, Asaad M Assiri
OBJECTIVES: To determine the outcomes  of endoscopic dilatation of esophageal strictures in children. METHODS: Children younger than 18 years of age diagnosed with esophageal strictures over a period of 7 years (June 2010 to June 2017) were reviewed and analyzed retrospectively. The study took place at King Khalid University Hospital, Riyadh, Saudi Arabia. The patients' clinical characteristics, endoscopic findings, and details of the strictures, treatment, and outcomes were documented...
August 2018: Saudi Medical Journal
Pierre Regenass, Dayana Abboud, François Daubeuf, Christine Lehalle, Patrick Gizzi, Stéphanie Riché, Muriel Hachet-Haas, François Rohmer, Vincent Gasparik, Damien Boeglin, Jacques Haiech, Tim Knehans, Didier Rognan, Denis Heissler, Claire Marsol, Pascal Villa, Jean-Luc Galzi, Marcel Hibert, Nelly Frossard, Dominique Bonnet
We previously reported small molecules that bind the chemokine CXCL12, not its cognate receptors CXCR4 or CXCR7, and neutralize its biological activity. These neutraligands encompass a chalcone chemotype, and suffer from limitations such as poor chemical stability, solubility and oral activity. Herein, we report a systematic structure-activity relationship study around the first neutraligand of CXCL12, Chalcone 4 (1) resulting in the discovery of pyrimidinone 57 (LIT-927), a novel neutraligand of CXCL12 which displays a higher solubility than 1...
August 14, 2018: Journal of Medicinal Chemistry
Sriroopreddy Ramireddy, P Raghuraman, Pradhyum Khandelwal, Jayanthi Abraham, C Sudandiradoss
Asthma, a chronic lung disease characterized by obstruction of airway passage is characterized by inflammation and hyperresponsiveness with increase in the number of eosinophils. Interleukin-13, plays a significant role in causing inflammation during an asthmatic attack by bronchial constriction. Mometasone, a glucocorticoid has been used as the first line of administration for people affected with asthma for almost a decade. However, in several cases, people treated with mometasone have faced systemic and local side effects...
August 2018: 3 Biotech
Emma J Raftis, Margaret I Delday, Philip Cowie, Seánín M McCluskey, Mark D Singh, Anna Ettorre, Imke E Mulder
Asthma is a phenotypically heterogeneous disease. In severe asthma, airway inflammation can be predominantly eosinophilic, neutrophilic, or mixed. Only a limited number of drug candidates are in development to address this unmet clinical need. Live biotherapeutics derived from the gut microbiota are a promising new therapeutic area. MRx0004 is a commensal Bifidobacterium breve strain isolated from the microbiota of a healthy human. The strain was tested prophylactically and therapeutically by oral gavage in a house dust mite mouse model of severe asthma...
August 13, 2018: Scientific Reports
Hongbiao Jing, Hong Wei, Hongtu Yuan, Yahong Li, Ning Li, Dianbin Mu
BACKGROUND: Melanotic Xp11 translocation renal cancer (TRC) is a newly described exceedingly rare tumor, and its characterization remains controversial. This study aimed to describe a case of distinctive melanotic Xp11 TRC and to elucidate its clinicopathological and molecular genetic features. CASE PRESENTATION: A 44-year-old Chinese female presented with a left renal mass. Abdominal ultrasonography and computed tomography (CT) scans revealed a 4.5 cm × 4...
August 13, 2018: Diagnostic Pathology
Jowanka Amorim, Marcos de Carvalho Borges, Alexandre Todorovic Fabro, Silvia Helena Taleb Contini, Mayara Valdevite, Ana Maria Soares Pereira, Fabio Carmona
ETHNOPHARMACOLOGICAL RELEVANCE: Erythrina mulungu Benth. ("mulungu", Fabaceae) is a Brazilian native species with ethnopharmacological use for respiratory diseases. However, the effects of E. mulungu on the respiratory were never studied. AIMS OF THE STUDY: To evaluate the effects of an ethanolic extract from flowers of E. mulungu in ovalbumin (OVA)-induced asthma in mice, and to study the mechanisms involved. MATERIALS AND METHODS: OVA-sensitized mice were intraperitoneally (i...
August 10, 2018: Journal of Ethnopharmacology
Tsutomu Shinohara, Shoutaro Tsuji, Yoshio Okano, Hisanori Machida, Nobuo Hatakeyama, Fumitaka Ogushi
Objective Human intelectin-1 (hITLN-1) binds to galactofuranosyl residues, which are present in the microbial cell wall, but which are absent in mammalian tissues, and has been suggested to play an immunological role against microorganisms. However, the involvement of hITLN-1 in the pathogenesis of diffuse pulmonary diseases remains unknown. The aim of this study was to compare the hITLN-1 concentrations in the bronchoalveolar lavage (BAL) fluid of patients with diffuse pulmonary diseases. Methods The cell components and concentrations of hITLN-1 were analyzed in the bronchoalveolar lavage (BAL) fluid of 8 patients with idiopathic chronic eosinophilic pneumonia (ICEP), 3 patients with drug-induced eosinophilic pneumonia (drug-EP), 4 patients with hypersensitivity pneumonitis (HP), 11 patients with sarcoidosis, 9 patients with cryptogenic organizing pneumonia (COP), and 5 patients with idiopathic fibrosing interstitial pneumonia (fibrosing nonspecific interstitial pneumonia [fNSIP] or usual interstitial pneumonia [UIP]) Results The hITLN-1 concentrations in the BAL fluid of patients with ICEP and HP were higher than in those with other diseases...
August 10, 2018: Internal Medicine
Marina Miletic Kovacevic, Nada Pejnovic, Slobodanka Mitrovic, Nemanja Jovicic, Ivica Petrovic, Nebojsa Arsenijevic, Miodrag L Lukic, Biljana Ljujic
Experimental autoimmune myocarditis (EAM) is a mouse model of immune-mediated myocarditis and cardiomyopathy. The role of Galectin-3 (Gal-3), a β-galactoside-binding lectin, in autoimmune myocarditis has not been studied. Therefore, the aim of this study was to delineate the role of Gal-3 in myosin peptide-induced autoimmune myocarditis in mice. EAM was induced in relatively resistant C57BL/6J mice (wild type, WT) and in mice with a targeted deletion of Gal-3 gene (Gal-3KO) by immunization with myosin peptide MyHCα334-352 ...
August 11, 2018: Immunologic Research
Wladyslaw Januszewicz, Wei Keith Tan, Katie Lehovsky, Irene Debiram-Beecham, Tara Nuckcheddy, Susan Moist, Sudarshan Kadri, Massimiliano di Pietro, Alex Boussioutas, Nicholas J Shaheen, David A Katzka, Evan S Dellon, Rebecca C Fitzgerald
BACKGROUND AND AIMS: Diagnosis and surveillance of Barrett's esophagus (BE) and eosinophilic esophagitis (EoE) have become emerging public health issues. Cytosponge® is a novel, minimally invasive esophageal cell collection device. We aimed to assess the data on safety and acceptability of this device. METHODS: We performed a patient-level review of 5 prospective trials assessing Cytosponge® performance in patients with reflux disease, BE and EoE in primary and secondary care...
August 9, 2018: Clinical Gastroenterology and Hepatology
Dante De Paz, Kai-Ping Chang, Huang-Kai Kao, William Wei-Kai Lao, Yu-Chen Huang, Yu-Liang Chang, Yenlin Huang
OBJECTIVES/HYPOTHESIS: The role of tumor-associated tissue eosinophilia (TATE) in oral cavity cancer remains quite controversial. This study investigated the potential role of TATE in tongue squamous cell carcinoma (TSCC). STUDY DESIGN: Retrospective case series. METHODS: This study retrospectively enrolled 259 consecutive TSCC patients who underwent surgery between July 2004 and December 2015. Histopathological examinations for TATE in TSCC tumors were reviewed, and the association of TATE with different clinicopathological factors was evaluated...
August 10, 2018: Laryngoscope
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