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histology and obstetrics

Byung Su Kwon, Jung Mi Byun, Hyun Joo Lee, Dae Hoon Jeong, Tae Hwa Lee, Kyung-Hwa Shin, Dong Soo Suh, Ki Hyung Kim
Purpose: We investigated the clinical relevance and spectrum of BRCA1/2 mutations in Korean ovarian cancer (KoOC) patients. Materials and Methods: Two hundred seventy-nine KoOC patients were enrolled from three university hospitals between 2012 and 2017. Their peripheral blood samples were obtained for BRCA1/2 mutation analysis by direct sequencing. Clinicopathological characteristics were retrospectively reviewed, and spectrum analyses of BRCA1/2 mutation were assessed by systematic literature review...
October 8, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Priscilla Dunyo, Kofi Effah, Emilia Asuquo Udofia
BACKGROUND: Cervical cancer is the leading and most common female cancer among women in Ghana. Although there are screening methods to detect premalignant lesions for treatment, screening coverage in Ghana is 2.8% and late presentation of cases complicates treatment efforts. This study examined the sociodemographic, clinical and histological characteristics associated with late presentation of cervical cancer cases attending Gynecological Oncology care at Catholic Hospital, Battor. METHODS: One hundred and fifty-seven medical records of confirmed cases of cervical cancer reporting to the Outpatient Obstetrics and Gynecology Department between 2012 and 2016 were reviewed...
October 3, 2018: BMC Public Health
Aime Powell, Paul A Cohen, Katrina Spilsbury, Nerida Steel, Penny Blomfield
BACKGROUND: For Australian women with screen-detected adenocarcinoma-in-situ (AIS), an excisional biopsy is mandatory for further assessment, treatment, and to exclude the presence of cervical adenocarcinoma. The only exclusion to this rule is if the woman has a clinically evident invasive cervical malignancy. Excisional treatments should be tailored according to a patient's age and future obstetric needs. To date, practitioner compliance with this recommendation has not been investigated...
October 4, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
Jiayao Lei, Alexander Ploner, Camilla Lagheden, Carina Eklund, Sara Nordqvist Kleppe, Bengt Andrae, K Miriam Elfström, Joakim Dillner, Pär Sparén, Karin Sundström
BACKGROUND: High-risk human papillomavirus (hrHPV) infection is established as the major cause of invasive cervical cancer (ICC). However, whether hrHPV status in the tumor is associated with subsequent prognosis of ICC is controversial. We aim to evaluate the association between tumor hrHPV status and ICC prognosis using national registers and comprehensive human papillomavirus (HPV) genotyping. METHODS AND FINDINGS: In this nationwide population-based cohort study, we identified all ICC diagnosed in Sweden during the years 2002-2011 (4,254 confirmed cases), requested all archival formalin-fixed paraffin-embedded blocks, and performed HPV genotyping...
October 2018: PLoS Medicine
Mohamed A Elshaikh, Ankit Modh, Sharif Sakr, Resha Shrestha, Charlotte Burmeister, Rouba Ali-Fehmi, Rabbie K Hanna
OBJECTIVES: Available risk stratification methods for women with endometrial carcinoma are controversially defined. We sought to develop a simplified and an individualized prognostic index for cancer recurrence in women with International Federation of Gynecology and Obstetrics (FIGO) stage I endometrial carcinoma, solely of endometrioid histology. MATERIALS AND METHODS: We identified 976 women who underwent a hysterectomy and did not receive any adjuvant therapy...
September 26, 2018: American Journal of Clinical Oncology
Arya Amini, Tyler P Robin, Priscilla K Stumpf, Chad Rusthoven, Tracey E Schefter, Ashwin Shinde, Yi-Jen Chen, Scott M Glaser, Bradley R Corr, Christine M Fisher
OBJECTIVE: In this study, we analyzed patterns of care for patients with locally advanced cervical cancer to identify predictors for upfront surgery compared with definitive chemoradiation (CRT). METHODS: The National Cancer Database was queried for patients aged 18 years or older with Federation of Gynecology and Obstetrics IB2-IIB cervical cancer. All patients underwent either upfront hysterectomy with or without postoperative radiation therapy versus definitive CRT...
October 2018: International Journal of Gynecological Cancer
Clodagh Mullen, Ashley N Battarbee, Linda M Ernst, Alan M Peaceman
OBJECTIVE:  To assess the risk factors, adverse obstetrical outcomes, and recurrence risk associated with pathologically diagnosed occult placenta accreta. METHODS:  This was a retrospective observational study of clinically adherent placentas requiring manual extraction that underwent pathological examination. Cases were defined as those with histological evidence of placenta accreta, and controls were defined as those without accreta. All subsequent pregnancies were evaluated to determine the recurrence risk of occult accreta in future pregnancies...
September 5, 2018: American Journal of Perinatology
Ming-Shyen Yen, Tze-Ho Chen, Yu-Min Ke, Keng-Fu Hsu, Jen-Ruei Chen, Mu-Hsien Yu, Hung-Chun Fu, Chia-Yen Huang, An-Jen Chiang, Chao-Yu Chen, Sheng-Mou Hsiao, Yuen-Yee Kan, Fu-Shing Liu
To investigate the clinicopathological features and treatment outcomes in patients with stage I, high-risk endometrial cancer. Patients with International Federation of Gynecology and Obstetrics stage I, papillary serous, clear cell, or grade 3 endometrioid carcinoma treated between 2000 and 2012 were analyzed for the clinical and pathological factors in relation to prognosis. A total of 267 patients (stage IA; n = 175, stage IB; n = 92) were included. Among the clinicopathological features, stage and age were significant prognostic factors...
September 4, 2018: Journal of Clinical Medicine
Ahmed El-Balat, Iryna Schmeil, Khayal Gasimli, Nicole Sänger, Thomas Karn, Andre Ahr, Sven Becker, Ruza Arsenic, Uwe Holtrich, Knut Engels
AIMS: Expression of Claudin-1 has been associated with prognosis in several cancers. Here we investigated the expression pattern of Claudin-1 in borderline tumours of the ovary (BOT). METHODS: We analysed a cohort of 114 cases of borderline tumour (BOT). Claudin-1 expression was studied by immunohistochemistry using a polyclonal antibody and was compared with clinical and histopathological characteristics. RESULTS: Strong Claudin-1 expression was found in 30 cases (26...
August 31, 2018: Journal of Clinical Pathology
Ji Zhang, Weizhong Tian, Xinhua Bu, Xiulan Wang, Fangzheng Tian, Linyun Wu
Background Patients with uterine cervical cancer suffer high mortality. Accurate detection of a residual tumor by magnetic resonance imaging (MRI) during and after directed brachytherapy (BCT) is crucial for the success of cancer treatment and is a significant predictor of patient survival. Purpose To determine the diagnostic significance of MRI in detecting residual tumor tissue after BCT. Material and Methods The Web of Knowledge, Cochrane Library, and PubMed were systematically searched (January 1997 to December 2016) for post-brachytherapy MRI studies that measured residual tumors in patients with uterine cervical cancer...
August 27, 2018: Acta Radiologica
Joana Aidos, Renata Veríssimo, Joana Almeida, Teresa Carvalho, Nuno Nogueira Martins, Francisco Nogueira Martins
OBJECTIVE:  Intraoperative frozen section (IFS) is a valuable resource, and its use in gynecological pathology has not been sufficiently emphasized. The main goal of the present study is to evaluate the reliability and agreement rates between IFS and the final paraffin section (PS) and determine how reliable IFS is. METHODS:  A retrospective study of all IFSs performed on uterine tumors and suspicious adnexal masses between January 2012 and December 2016 (excluding metastases) at the department of obstetrics and gynecology of the Centro Hospitalar Tondela Viseu...
August 2018: Revista Brasileira de Ginecologia e Obstetrícia
Amilcar Barreta, Luis Sarian, Amanda Canato Ferracini, Larissa Eloy, Angelo Borsarelli Carvalho Brito, Liliana de Angelo Andrade, Sophie Derchain
OBJECTIVE: The aim of this study was to analyze and compare the clinicopathologic features and prognosis of clear cell ovarian carcinoma (CCOC) and endometrioid ovarian carcinoma (EOC) associated or not with endometriosis. METHODS: This was a reconstituted cohort study from a single-institution Brazilian cancer center approved under review board no. 68150617.7.0000.5404 with 50 patients with CCOC and EOC diagnosed between 1995 and 2016, followed up until 2017. Clinicopathologic characteristics and survival outcomes were analyzed...
September 2018: International Journal of Gynecological Cancer
Jvan Casarin, Francesco Multinu, Kalyan Pasupathy, Amy Weaver, Michaela McGree, Lucia Tortorella, Diogo Torres, Amanika Kumar, Carrie Langstraat, Yajue Huang, Fabio Ghezzi, Andrea Mariani, Gretchen Glaser
OBJECTIVE: The aim of this study was to assess the role of frozen section (FS) in identifying an absence of lymph nodes during sentinel lymph node (SLN) biopsy for apparent early-stage endometrial cancer (EC). METHODS: Consecutive apparent early-stage EC patients who had SLNs removed after cervical injection with indocyanine green (ICG) from 1 June 2014 to 30 June 2016 were analyzed. An empty node (EN) was defined as an SLN specimen without evidence of lymph node(s)...
August 16, 2018: Annals of Surgical Oncology
Kenji Yoshikawa, Takeshi Fukuda, Ryo Uemura, Hiroaki Matsubara, Takuma Wada, Masaru Kawanishi, Reiko Tasaka, Mari Kasai, Yasunori Hashiguchi, Tomoyuki Ichimura, Tomoyo Yasui, Toshiyuki Sumi
Approximately 40% of all patients with ovarian cancer in Japan are aged ≥65 years. The aim of the present study was to evaluate the differences in prognosis and prognostic factors between elderly and younger patients with epithelial ovarian cancer. A total of 114 patients with International Federation of Gynecology and Obstetrics (FIGO) stage I-IV ovarian cancer who were initiated on primary treatment at the Osaka City University Hospital (Osaka, Japan) were included in this study. Patient characteristics, treatment outcome and prognosis were compared between elderly (aged ≥65 years) and younger patients, and the prognostic factors associated with overall survival were evaluated by univariate and multivariate analyses...
September 2018: Molecular and Clinical Oncology
X Z Zheng, X Y Qin, P Wang, F Xu, J H Ma, X L Wang, S W Chen, W Q Feng, L Zhu, C H Yin, B Q Wu
Objective: To investigate the value of short tandem repeat (STR) genotyping in the diagnostic workup of molar and non-molar gestations with correlation of histological characteristics. Methods: Six hundred and fifty-six cases were selected based on clinically suspected hydropic abortion and/or molar pregnancy from July 2015 to September 2017 at Beijing Obstetrics and Gynecology Hospital. DNA was extracted from dissected chorionic villi and paired maternal endometrial FFPE tissue samples by Simplex OUP™ FFPE DNA Tissue Kit...
August 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Natsuo Tomita, Mika Mizuno, Chiyoko Makita, Shinji Kondo, Masahiko Mori, Jun Sakata, Hirofumi Tsubouchi, Kimiko Hirata, Hiroyuki Tachibana, Takeshi Kodaira
OBJECTIVE: The aim of this study was to compare the outcomes and toxicities of radical hysterectomy (RH) and definitive chemoradiation (CRT) for International Federation of Gynecology and Obstetrics (FIGO) stage IIB cervical cancer. MATERIALS AND METHODS: A retrospective analysis was performed on FIGO stage IIB patients who underwent RH with adjuvant radiotherapy (surgery group) or intended to receive CRT (CRT group). The distributions of disease-free survival (DFS) and overall survival (OS) were calculated using the Kaplan-Meier method...
August 7, 2018: International Journal of Gynecological Cancer
Diya Das, Moumita Sengupta, Keya Basu, Mona Tirkey, Chhanda Datta, Uttara Chatterjee
Background: Pap-smears-based cytology and human papilloma virus testing have their own limitations in detecting cervical precancerous lesions, and still need further standardization. Co-expression of p16ink4a and Ki-67 can be used as additional biomarker. Aims: To study the role of liquid-based cytology and the dual immunostaining for p16/Ki-67 in predicting the presence of significant lesion in cases of mild cytological atypia. Materials and Methods: A prospective, cross-sectional study was performed in the Department of Pathology, in collaboration with Department of Obstetrics and Gynecology over 15 months including 545 patients...
July 2018: Journal of Cytology
Erik Kudela, Jozef Visnovsky, Tomas Balharek, Anna Farkasova, Pavol Zubor, Lukas Plank, Jan Danko
PURPOSE: The aim of this study was to evaluate and correlate the amplification of chromosomal regions 3q26 and 5p15 in different cytological and histological subgroups of patients and to compare the sensitivity and specificity of amplification tests with cytology, colposcopy and HPV status. METHODS: The work was conducted at the Department of Obstetrics and Gynaecology in cooperation with the Institute of Pathological Anatomy, JFM CU in Martin and UNM during years 2013-2016...
August 2018: Annals of Diagnostic Pathology
Dina Bassiouny, Mahmoud A El-Baz, Tawakol M Gamil, Nazem Shams, Nadia Ismiil, Valerie Dubé, Guangming Han, Matthew Cesari, Fang-I Lu, Elzbieta Slodkowska, Hak Fai Chiu, Magda Naeim, Nim Li, Sharon Nofech-Mozes, Mahmoud A Khalifa
There is a controversy about whether endometriosis-associated ovarian cancer (EAOC) might represent a different entity from the corresponding ovarian cancer occurring de novo, in the absence of endometriosis. This study investigated the clinical-pathologic characteristics and outcome of EAOC compared with other ovarian carcinomas that are not associated with endometriosis (non-EAOC) in a large cohort. Seven hundred two patients meeting the inclusion criteria were further subclassified as group I when patients had ovarian carcinoma associated with or arising within endometriosis (EAOC) and group II when patients had non-EAOC...
July 27, 2018: International Journal of Gynecological Pathology
Gigin Lin, Lan-Yan Yang, Yu-Chun Lin, Yu-Ting Huang, Feng-Yuan Liu, Chun-Chieh Wang, Hsin-Ying Lu, Hsin-Ju Chiang, Yu-Ruei Chen, Ren-Chin Wu, Koon-Kwan Ng, Ji-Hong Hong, Tzu-Chen Yen, Chyong-Huey Lai
OBJECTIVES: To develop and validate a prognostic model of integrating whole-tumour apparent diffusion coefficient (ADC) from pretreatment diffusion-weighted (DW) magnetic resonance (MR) imaging with human papillomavirus (HPV) genotyping in predicting the overall survival (OS) and disease-free survival (DFS) for women with stage IB-IV cervical cancer following concurrent chemoradiotherapy (CCRT). METHODS: We retrospectively analysed three prospectively collected cohorts comprising 300 patients with stage IB-IV cervical cancer treated with CCRT in 2007-2014 and filtered 134 female patients who underwent MR imaging at 3...
July 26, 2018: European Radiology
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