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histology and obstetrics

Joanna Jonska-Gmyrek, Leszek Gmyrek, Agnieszka Zolciak-Siwinska, Maria Kowalska, Malgorzata Fuksiewicz, Beata Kotowicz
Objective: Our study assessed the clinical utility and prognostic value of pretreatment hematological parameters and calculated coefficients including the platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), and monocyte to lymphocyte ratio (MLR) in patients with cervical adenocarcinoma (CA). Materials and methods: Among 738 cervical cancer patients with International Federation of Gynecology and Obstetrics (FIGO) stages IA-IV treated at our institution, 96 (13%) presented with CA histology...
2018: Cancer Management and Research
Chanqiong Zhang, Chongan Huang, Xiang Zheng, Dan Pan
Background: Human papillomavirus (HPV) is associated with an increased risk of cervical cancer. Using a vaccine to prevent HPV infections could be a cost-effective strategy to decrease the incidence of cervical cancer. Learning about the characteristics of CIN patients with HPV infection in Wenzhou is a key step in guiding the use of HPV vaccines and screening for cervical cancer. Methods: We undertook a retrospective analysis including 2612 women who were treated in the Department of Gynecology and Obstetrics from Jan 2016 to Nov 2017...
2018: Infectious Agents and Cancer
Anne-Claude Muller Brochut, Patrick Taffe, Romain Piaget-Rossel, Laurence de Leval, Anne-Laure Rougemont
INTRODUCTION: Reference ranges in fetal postmortem anthropometric data derive from heterogeneous studies and rely on data obtained after intrauterine fetal death and abortion, which may introduce bias in the reported fetal growth parameters. We report anthropometric findings in fetuses with the least variation due to cause of death or developmental anomalies. METHODS: We analyzed fetuses after the termination of pregnancy for psychosocial reasons. The external measurements, X-ray dimensions, and body and organ weights were recorded as well as the placenta weight...
November 19, 2018: Pediatric and Developmental Pathology
P Vinklerová, L Minář, M Felsinger, M Anton, P Ventruba, M Bednaříková, J Hausnerová, E Jandáková, M Číhalová, V Weinberger
OBJECTIVE: The aim of the study was to describe the role of hormonal therapy in the treatment of malignant uterine tumors, indications, the effect of the treatment and to verify its safety in our study cohort. We also present an overview of recent studies on that topic. DESIGN: Unicentric retrospective observational study and review of recent literature. SETTING: Department of Obstetrics and Gynecology, Masaryk University, University Hospital Brno...
December 0: Ceská Gynekologie
Na Li, Lichun Chen, Chunying Liu, Yaping Jiang, Jiawei Rong
Collagen triple helix repeat containing 1 (CTHRC1) is overexpressed in different kinds of cancer tissues and may thus promote tumor formation. Thus, we aimed to explore whether CTHRC1 could be a predictor of clinical significance including survival in cervical squamous cell carcinoma (CSCC). Western blot analysis was conducted in 20 frozen tissue specimens of CSCC and 10 frozen tissue sections of normal cervix. Immunohistochemistry was performed in 130 tissues with CSCC. The relationships of CTHRC1 expression with clinicopathological variables, and prognosis of CSCCs were explored...
October 28, 2018: Human Pathology
Kaori Kiuchi, Kiyoshi Hasegawa, Shoko Ochiai, Emi Motegi, Tatsuya Kuno, Nobuaki Kosaka, Ichio Fukasawa
Recently, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) or prognostic nutritional index (PNI) have been investigated as prognostic parameters in various malignancies. Herein, we detail how we have investigated the prognostic significance of NLR, PLR and PNI together with the other clinicopathological factors for International Federation of Gynaecology and Obstetrics stage IVB endometrial carcinoma. Thirty-two patients with clinical stage IVB disease were enrolled. The relationship between clinicopathological factors, NLR, PLR or PNI and overall survival (OS) rates was investigated...
October 27, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Xingchen Zhou, Xiaoqian Yang, Huihui Chen, Xuhong Fang, Xipeng Wang
BACKGROUND: Although vaginal repair has been conducted to manage caesarean scar diverticula, most studies evaluated only the gynaecological outcomes post-surgery, and their obstetrical outcomes were unknown. This study aimed to evaluate the obstetrical outcomes in vaginal repair-treated caesarean scar diverticula patients. METHODS: A series of 51 symptomatic women with caesarean scar defects or a thickness of the remaining muscular layer of less than 3 mm according to transvaginal ultrasound were included...
October 19, 2018: BMC Pregnancy and Childbirth
Ying Liang, Tianli Zhang, Mengdie Shi, Shuo Zhang, Yaxing Guo, Jiwei Gao, Xingsheng Yang
Nuclear receptor coactivator 5 (NCOA5) specifically enhances estrogen receptor α-modulated transcriptional activity. As a novel tumor suppressor, depletion of NCOA5 is associated with the development of a variety of tumors, but its function in cervical cancer is currently unclear. In this study, we addressed how expression of NCOA5 changed in the development of human cervical cancer and its association with clinicopathological features, prognosis, and biology characteristics of cervical cancer. Analysis of the microarrays in the Oncomine database indicated that NCOA5 expression was lower in human cervical squamous cell carcinoma tissues than that in normal cervical tissues...
October 18, 2018: Journal of Cellular Biochemistry
Karolina Okła, Justyna Surówka, Karolina Frąszczak, Arkadiusz Czerwonka, Katarzyna Kaławaj, Anna Wawruszak, Jan Kotarski, Iwona Wertel
Ovarian cancer remains the most lethal gynecologic malignancy. This is due to lack of effective screening, diagnosis predominance in late stage of disease, a high recurrence rate after primary therapy, and poor treatment response in platinum-resistant tumor. Thus, unique biomarkers, predictive of individual disease course, and prognosis are urgently needed. The aim of our study was to assess the clinicopathological significance of plasma, peritoneal fluid, and tumor tissue levels of mesothelin in epithelial ovarian cancer patients...
October 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Fuat Demirkiran, Ilker Kahramanoglu, Tugan Bese, Hasan Turan, Elif Meseci, Macit Arvas
OBJECTIVES: Less radical fertility sparing procedures have been introduced to reduce morbidity and adverse obstetric outcome in cervical cancer. Our objective was to describe oncological and obstetric outcomes of women with early-stage cervical cancer who underwent a simple vaginal trachelectomy (SVT). MATERIAL AND METHODS: From 01/2013 to 05/2017, 14 women underwent SVT preceded by laparoscopic pelvic lymph node dissection. RESULTS: Patients' median age was 32 years and all of them were nulliparous...
2018: Ginekologia Polska
Byung Su Kwon, Jung Mi Byun, Hyun Joo Lee, Dae Hoon Jeong, Tae Hwa Lee, Kyung-Hwa Shin, Dong Soo Suh, Ki Hyung Kim
Purpose: We investigated the clinical relevance and spectrum of BRCA1/2 mutations in Korean ovarian cancer (KoOC) patients. Materials and Methods: Two hundred seventy-nine KoOC patients were enrolled from three university hospitals between 2012 and 2017. Their peripheral blood samples were obtained for BRCA1/2 mutation analysis by direct sequencing. Clinicopathological characteristics were retrospectively reviewed, and spectrum analyses of BRCA1/2 mutation were assessed by systematic literature review...
October 8, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Priscilla Dunyo, Kofi Effah, Emilia Asuquo Udofia
BACKGROUND: Cervical cancer is the leading and most common female cancer among women in Ghana. Although there are screening methods to detect premalignant lesions for treatment, screening coverage in Ghana is 2.8% and late presentation of cases complicates treatment efforts. This study examined the sociodemographic, clinical and histological characteristics associated with late presentation of cervical cancer cases attending Gynecological Oncology care at Catholic Hospital, Battor. METHODS: One hundred and fifty-seven medical records of confirmed cases of cervical cancer reporting to the Outpatient Obstetrics and Gynecology Department between 2012 and 2016 were reviewed...
October 3, 2018: BMC Public Health
Aime Powell, Paul A Cohen, Katrina Spilsbury, Nerida Steel, Penny Blomfield
BACKGROUND: For Australian women with screen-detected adenocarcinoma-in-situ (AIS), an excisional biopsy is mandatory for further assessment, treatment, and to exclude the presence of cervical adenocarcinoma. The only exclusion to this rule is if the woman has a clinically evident invasive cervical malignancy. Excisional treatments should be tailored according to a patient's age and future obstetric needs. To date, practitioner compliance with this recommendation has not been investigated...
October 4, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
Jiayao Lei, Alexander Ploner, Camilla Lagheden, Carina Eklund, Sara Nordqvist Kleppe, Bengt Andrae, K Miriam Elfström, Joakim Dillner, Pär Sparén, Karin Sundström
BACKGROUND: High-risk human papillomavirus (hrHPV) infection is established as the major cause of invasive cervical cancer (ICC). However, whether hrHPV status in the tumor is associated with subsequent prognosis of ICC is controversial. We aim to evaluate the association between tumor hrHPV status and ICC prognosis using national registers and comprehensive human papillomavirus (HPV) genotyping. METHODS AND FINDINGS: In this nationwide population-based cohort study, we identified all ICC diagnosed in Sweden during the years 2002-2011 (4,254 confirmed cases), requested all archival formalin-fixed paraffin-embedded blocks, and performed HPV genotyping...
October 2018: PLoS Medicine
Mohamed A Elshaikh, Ankit Modh, Sharif Sakr, Resha Shrestha, Charlotte Burmeister, Rouba Ali-Fehmi, Rabbie K Hanna
OBJECTIVES: Available risk stratification methods for women with endometrial carcinoma are controversially defined. We sought to develop a simplified and an individualized prognostic index for cancer recurrence in women with International Federation of Gynecology and Obstetrics (FIGO) stage I endometrial carcinoma, solely of endometrioid histology. MATERIALS AND METHODS: We identified 976 women who underwent a hysterectomy and did not receive any adjuvant therapy...
September 26, 2018: American Journal of Clinical Oncology
Arya Amini, Tyler P Robin, Priscilla K Stumpf, Chad Rusthoven, Tracey E Schefter, Ashwin Shinde, Yi-Jen Chen, Scott M Glaser, Bradley R Corr, Christine M Fisher
OBJECTIVE: In this study, we analyzed patterns of care for patients with locally advanced cervical cancer to identify predictors for upfront surgery compared with definitive chemoradiation (CRT). METHODS: The National Cancer Database was queried for patients aged 18 years or older with Federation of Gynecology and Obstetrics IB2-IIB cervical cancer. All patients underwent either upfront hysterectomy with or without postoperative radiation therapy versus definitive CRT...
October 2018: International Journal of Gynecological Cancer
Clodagh Mullen, Ashley N Battarbee, Linda M Ernst, Alan M Peaceman
OBJECTIVE:  To assess the risk factors, adverse obstetrical outcomes, and recurrence risk associated with pathologically diagnosed occult placenta accreta. METHODS:  This was a retrospective observational study of clinically adherent placentas requiring manual extraction that underwent pathological examination. Cases were defined as those with histological evidence of placenta accreta, and controls were defined as those without accreta. All subsequent pregnancies were evaluated to determine the recurrence risk of occult accreta in future pregnancies...
September 5, 2018: American Journal of Perinatology
Ming-Shyen Yen, Tze-Ho Chen, Yu-Min Ke, Keng-Fu Hsu, Jen-Ruei Chen, Mu-Hsien Yu, Hung-Chun Fu, Chia-Yen Huang, An-Jen Chiang, Chao-Yu Chen, Sheng-Mou Hsiao, Yuen-Yee Kan, Fu-Shing Liu
To investigate the clinicopathological features and treatment outcomes in patients with stage I, high-risk endometrial cancer. Patients with International Federation of Gynecology and Obstetrics stage I, papillary serous, clear cell, or grade 3 endometrioid carcinoma treated between 2000 and 2012 were analyzed for the clinical and pathological factors in relation to prognosis. A total of 267 patients (stage IA; n = 175, stage IB; n = 92) were included. Among the clinicopathological features, stage and age were significant prognostic factors...
September 4, 2018: Journal of Clinical Medicine
Ahmed El-Balat, Iryna Schmeil, Khayal Gasimli, Nicole Sänger, Thomas Karn, Andre Ahr, Sven Becker, Ruza Arsenic, Uwe Holtrich, Knut Engels
AIMS: Expression of Claudin-1 has been associated with prognosis in several cancers. Here we investigated the expression pattern of Claudin-1 in borderline tumours of the ovary (BOT). METHODS: We analysed a cohort of 114 cases of borderline tumour (BOT). Claudin-1 expression was studied by immunohistochemistry using a polyclonal antibody and was compared with clinical and histopathological characteristics. RESULTS: Strong Claudin-1 expression was found in 30 cases (26...
August 31, 2018: Journal of Clinical Pathology
Ji Zhang, Weizhong Tian, Xinhua Bu, Xiulan Wang, Fangzheng Tian, Linyun Wu
Background Patients with uterine cervical cancer suffer high mortality. Accurate detection of a residual tumor by magnetic resonance imaging (MRI) during and after directed brachytherapy (BCT) is crucial for the success of cancer treatment and is a significant predictor of patient survival. Purpose To determine the diagnostic significance of MRI in detecting residual tumor tissue after BCT. Material and Methods The Web of Knowledge, Cochrane Library, and PubMed were systematically searched (January 1997 to December 2016) for post-brachytherapy MRI studies that measured residual tumors in patients with uterine cervical cancer...
August 27, 2018: Acta Radiologica
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