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https://www.readbyqxmd.com/read/30095702/propensity-score-analysis-of-radical-hysterectomy-versus-definitive-chemoradiation-for-figo-stage-iib-cervical-cancer
#1
Natsuo Tomita, Mika Mizuno, Chiyoko Makita, Shinji Kondo, Masahiko Mori, Jun Sakata, Hirofumi Tsubouchi, Kimiko Hirata, Hiroyuki Tachibana, Takeshi Kodaira
OBJECTIVE: The aim of this study was to compare the outcomes and toxicities of radical hysterectomy (RH) and definitive chemoradiation (CRT) for International Federation of Gynecology and Obstetrics (FIGO) stage IIB cervical cancer. MATERIALS AND METHODS: A retrospective analysis was performed on FIGO stage IIB patients who underwent RH with adjuvant radiotherapy (surgery group) or intended to receive CRT (CRT group). The distributions of disease-free survival (DFS) and overall survival (OS) were calculated using the Kaplan-Meier method...
August 7, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/30089944/role-of-p16-ki-67-dual-immunostaining-in-detection-of-cervical-cancer-precursors
#2
Diya Das, Moumita Sengupta, Keya Basu, Mona Tirkey, Chhanda Datta, Uttara Chatterjee
Background: Pap-smears-based cytology and human papilloma virus testing have their own limitations in detecting cervical precancerous lesions, and still need further standardization. Co-expression of p16ink4a and Ki-67 can be used as additional biomarker. Aims: To study the role of liquid-based cytology and the dual immunostaining for p16/Ki-67 in predicting the presence of significant lesion in cases of mild cytological atypia. Materials and Methods: A prospective, cross-sectional study was performed in the Department of Pathology, in collaboration with Department of Obstetrics and Gynecology over 15 months including 545 patients...
July 2018: Journal of Cytology
https://www.readbyqxmd.com/read/30072014/different-amplification-patterns-of-3q26-and-5p15-regions-in-cervical-intraepithelial-neoplasia-and-cervical-cancer
#3
Erik Kudela, Jozef Visnovsky, Tomas Balharek, Anna Farkasova, Pavol Zubor, Lukas Plank, Jan Danko
PURPOSE: The aim of this study was to evaluate and correlate the amplification of chromosomal regions 3q26 and 5p15 in different cytological and histological subgroups of patients and to compare the sensitivity and specificity of amplification tests with cytology, colposcopy and HPV status. METHODS: The work was conducted at the Department of Obstetrics and Gynaecology in cooperation with the Institute of Pathological Anatomy, JFM CU in Martin and UNM during years 2013-2016...
August 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/30059454/endometriosis-associated-ovarian-cancer-is-a-subset-with-a-more-favorable-outcome-and-distinct-clinical-pathologic-characteristics
#4
Dina Bassiouny, Mahmoud A El-Baz, Tawakol M Gamil, Nazem Shams, Nadia Ismiil, Valerie Dubé, Guangming Han, Matthew Cesari, Fang-I Lu, Elzbieta Slodkowska, Hak Fai Chiu, Magda Naeim, Nim Li, Sharon Nofech-Mozes, Mahmoud A Khalifa
There is a controversy about whether endometriosis-associated ovarian cancer (EAOC) might represent a different entity from the corresponding ovarian cancer occurring de novo, in the absence of endometriosis. This study investigated the clinical-pathologic characteristics and outcome of EAOC compared with other ovarian carcinomas that are not associated with endometriosis (non-EAOC) in a large cohort. Seven hundred two patients meeting the inclusion criteria were further subclassified as group I when patients had ovarian carcinoma associated with or arising within endometriosis (EAOC) and group II when patients had non-EAOC...
July 27, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30051142/prognostic-model-based-on-magnetic-resonance-imaging-whole-tumour-apparent-diffusion-coefficient-values-and-hpv-genotyping-for-stage-ib-iv-cervical-cancer-patients-following-chemoradiotherapy
#5
Gigin Lin, Lan-Yan Yang, Yu-Chun Lin, Yu-Ting Huang, Feng-Yuan Liu, Chun-Chieh Wang, Hsin-Ying Lu, Hsin-Ju Chiang, Yu-Ruei Chen, Ren-Chin Wu, Koon-Kwan Ng, Ji-Hong Hong, Tzu-Chen Yen, Chyong-Huey Lai
OBJECTIVES: To develop and validate a prognostic model of integrating whole-tumour apparent diffusion coefficient (ADC) from pretreatment diffusion-weighted (DW) magnetic resonance (MR) imaging with human papillomavirus (HPV) genotyping in predicting the overall survival (OS) and disease-free survival (DFS) for women with stage IB-IV cervical cancer following concurrent chemoradiotherapy (CCRT). METHODS: We retrospectively analysed three prospectively collected cohorts comprising 300 patients with stage IB-IV cervical cancer treated with CCRT in 2007-2014 and filtered 134 female patients who underwent MR imaging at 3...
July 26, 2018: European Radiology
https://www.readbyqxmd.com/read/30050604/-radio-histological-correlation-of-acr4-microcalcifications-in-breast-lesions-about-181-cases-and-literature-review
#6
Ahmed Guennoun, Yousra Krimou, Chahrazed Bouchikhi, Nisrine Mamouni, Sanaa Errarhay, Abdelaziz Banani
The Bi-RADS (Breast Imaging Reporting and Data System) classification developed by the ACR (American College of Radiology) is the classification system for radiological images recommended for breast cancer screening. The ACR 4 microcalcification is an indeterminate or suspected abnormality with 2-95% probability of malignancy, according to studies. This disparity pushed us to conduct this retrospective study of 181 patients in the Department of Obstetrics and Gynecology I at the Hassan II University Hospital, Fez, over a period of 5 years...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/30044764/the-frequency-and-type-of-placental-histologic-lesions-in-term-pregnancies-with-normal-outcome
#7
Roberto Romero, Yeon Mee Kim, Percy Pacora, Chong Jai Kim, Neta Benshalom-Tirosh, Sunil Jaiman, Gaurav Bhatti, Jung-Sun Kim, Faisal Qureshi, Suzanne M Jacques, Eun Jung Jung, Lami Yeo, Bogdan Panaitescu, Eli Maymon, Sonia S Hassan, Chaur-Dong Hsu, Offer Erez
Objective To determine the frequency and type of histopathologic lesions in placentas delivered by women with a normal pregnancy outcome. Methods This retrospective cohort study included placental samples from 944 women with a singleton gestation who delivered at term without obstetrical complications. Placental lesions were classified into the following four categories as defined by the Society for Pediatric Pathology and by our unit: (1) acute placental inflammation, (2) chronic placental inflammation, (3) maternal vascular malperfusion and (4) fetal vascular malperfusion...
July 25, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/30036224/comparative-use-of-napsin-a-and-glypican-3-to-distinguish-endometrial-clear-cell-from-serous-and-endometrioid-carcinomas
#8
Eirwen M Miller, Joan Tymon-Rosario, Jaya Sunkara, Bryan E Harmon, Rouzan G Karabakhtsian, Akiva P Novetsky
OBJECTIVE: Diagnosis of endometrial clear cell carcinomas is difficult owing to the low reproducibility of histological cell type in high-grade endometrial cancers. Recently, immunoreactivity for napsin A and glypican 3 has been reported in clear cell cancers. We sought to evaluate the use of napsin A and glypican 3 staining to distinguish clear cell carcinoma from other high-grade endometrial cancers. METHODS/MATERIALS: Twenty cases of pure and mixed endometrial clear cell carcinoma were extracted from the 2000-2014 archival material in the Departments of Obstetrics & Gynecology and Pathology at Montefiore Medical Center and compared to serous and grade 3 endometrioid controls...
July 20, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/30024495/clinical-significance-of-matrix-metalloproteinase-2-in-endometrial-cancer-a-systematic-review-and-meta-analysis
#9
REVIEW
Chang Liu, Ying Li, Shasha Hu, Yao Chen, Li Gao, Dajiang Liu, Hongtao Guo, Yongxiu Yang
BACKGROUND: Matrix metalloproteinase-2 (MMP-2), a member of the zinc-dependent metalloproteinase gene family, plays a vital role in cancer invasion, metastasis, and progression. This systematic review and meta-analysis aims to explore the clinical significance of MMP-2 expression in endometrial cancer. METHODS: PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure databases were systematically searched up to September 30, 2017, supplemented by manual searches of bibliographies...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30022636/treatment-outcomes-of-patients-with-stage-ii-pure-endometrioid-type-endometrial-cancer-a-taiwanese-gynecologic-oncology-group-tgog-2006-retrospective-cohort-study
#10
Hung Chun Fu, Jen Ruei Chen, Min Yu Chen, Keng Fu Hsu, Wen Fang Cheng, An Jen Chiang, Yu Min Ke, Yu Chieh Chen, Yin Yi Chang, Chia Yen Huang, Chieh Yi Kang, Yuan Yee Kan, Sheng Mou Hsiao, Ming Shyen Yen
OBJECTIVE: Choice of hysterectomy and adjuvant treatment for International Federation of Gynecology and Obstetrics (FIGO) 2009 stage II endometrioid endometrial cancer (EEC) is still controversial. Aims of this study were to evaluate survival benefits and adverse effects of different hysterectomies with or without adjuvant radiotherapy (RT), and to identify prognostic factors. METHODS: The patients at 14 member hospitals of the Taiwanese Gynecologic Oncology Group from 1992 to 2013 were retrospectively investigated...
September 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/30022631/clinical-associations-of-trousseau-s-syndrome-associated-with-cerebral-infarction-and-ovarian-cancer
#11
Hirokuni Takano, Keiko Nakajima, Yoko Nagayoshi, Hiromi Komazaki, Jiro Suzuki, Hiroshi Tanabe, Shigeki Niimi, Seiji Isonishi, Aikou Okamoto
OBJECTIVE: Since there have been few large series studies to date, we investigated the relationship between Trousseau's syndrome associated with cerebral infarction and its clinical associations with ovarian cancer. METHODS: In this study, we investigated the association between cerebral infarction onset and ovarian cancer. Eight-hundred twenty-seven consecutive ovarian cancer patients from 4 affiliated academic institutions were included in the study over a 12 years period...
September 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/30022627/prognostic-impact-of-reduced-tumor-free-margin-distance-on-long-term-survival-in-figo-stage-ib-ii-vulvar-squamous-cell-carcinoma
#12
Leonardo Micheletti, Mario Preti, Viviana Cintolesi, Elisabetta Corvetto, Silvana Privitera, Eleonora Palmese, Chiara Benedetto
OBJECTIVE: We aimed to identify the minimum tumor-free margin distance conferring long-term oncological safety in patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IB/II vulvar squamous cell carcinoma (VSCC). METHODS: This was a retrospective cohort study in patients with stage IB/II VSCC treated at a single institution in Turin, Italy. The main aim was to identify the minimum tumor-free margin distance that confers oncological safety in early-stage VSCC...
September 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/30019801/potential-risk-factors-associated-with-prognosis-of-neoadjuvant-chemotherapy-followed-by-interval-debulking-surgery-in-stage-iiic-iv-high-grade-serous-ovarian-carcinoma-patients
#13
Jie Zhang, Ning Liu, Aihong Zhang, Xiangxiang Bao
AIM: No consensus has been achieved on the prognostic factors for patients with advanced stage epithelial ovarian cancer who underwent neoadjuvant chemotherapy (NAC) followed by interval debulking surgery (IDS). This study aimed to investigate the prognostic factors for the patients diagnosed as International Federation of Gynecology and Obstetrics stage IIIc-IV high-grade serous ovarian cancer (HG-SOC). METHODS: A total of 200 patients histologically diagnosed as IIIc-IV stage HG-SOC were retrospectively analyzed...
July 18, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/30019594/adenocarcinoma-histology-is-a-poor-prognostic-factor-in-locally-advanced-cervical-cancer
#14
Joanna Jonska-Gmyrek, Leszek Gmyrek, Agnieszka Zolciak-Siwinska, Maria Kowalska, Beata Kotowicz
OBJECTIVE: This retrospective study aimed to compare prognostic factors and survival between adenocarcinoma (AC) and squamous cell carcinoma (SCC) in locally advanced cervical cancer treated at a single center. METHODS: All medical records of cervical cancer patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIB or IIIA,B, treated between 2004 and 2012, were reviewed. We treated patients with chemoradiotherapy (CRT) followed by brachytherapy (BT)...
August 10, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30018901/the-comparison-of-surgical-outcomes-and-learning-curves-of-radical-hysterectomy-by-laparoscopy-and-robotic-system-for-cervical-cancer-an-experience-of-a-single-surgeon
#15
Yoon Jung Heo, Seongmin Kim, Kyung Jin Min, Sanghoon Lee, Jin Hwa Hong, Jae Kwan Lee, Nak Woo Lee, Jae Yun Song
Objective: The aim of this study was to compare and determine the feasibility, surgical outcomes, learning curves of robotic radical hysterectomy with lymph node dissection (RRHND) to conventional laparoscopic radical hysterectomy with lymph node dissection (LRHND) performed by a single surgeon, in patients with cervical cancer. Methods: Between April 2009 and March 2013, 22 patients underwent LRHND and 19 patients underwent RRHND. Variables such as age, body mass index, International Federation of Gynecology and Obstetrics stage, histological results, number of dissected lymph nodes, operative time, estimated blood loss, days of hospitalization and complications were reviewed...
July 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29994911/predictive-value-of-kanagawa-cancer-center-scoring-system-for-lymph-node-metastasis-and-need-for-lymphadenectomy-in-patients-with-endometrial-cancer-a-validation-study
#16
Mozhdeh Momtahan, Marjan Hosseini, Minoo Robati, Fatemesadat Najib
OBJECTIVES: The objective of this study was to determine the predictive value of Kanagawa Cancer Center (KCC) scoring system for lymph node metastasis and need for lymphadenectomy in patients with endometrial cancer. METHODS: This cross-sectional study was conducted during a 2-year period in a gynecologic oncology referral center in Southern Iran. We included a total number of 94 patients with endometrial cancer. Preoperative assessment included tumor volume, myometrium invasion, histology, and CA125...
July 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29981172/prevalence-and-distribution-of-cervical-human-papillomavirus-hpv-genotypes-in-women-with-cytological-results-from-sichuan-province-china
#17
Bei Li, Hui Wang, Dan Yang, Jian Ma
The epidemiologic characteristics of HPV genotypes vary by age, ethnicity, geographic location and the available data of HPV epidemiological characteristics with cytology results in Sichuan province are limited. Our research was conducted from June 2016 to July 2017. A total of 10953 women getting HPV testing were enrolled. Liquid-based cytological results and histological results were collected. The overall HPV infection rate was 24.1% in Sichuan province. The prevalence of hrHPV were 19.9%. For hrHPV genotypes, HPV52 (15...
July 7, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29977634/unusual-case-of-a-torted-mesenteric-fibroid
#18
Rawan Bajis, Gregg Eloundou
Extrauterine leiomyomas are very rare and present a clinical and diagnostic challenge due to their unusual growth patterns and behaviours. A 47-year-old woman was transferred to our tertiary specialist obstetrics and gynaecology hospital with acute abdominal pain and a palpable abdominal mass. She was taken immediately to theatre with the presumptive diagnosis of an ovarian torsion. Intraoperatively, a large necrotic mass originating from the mesentery and attachments to the bowel at the ileocaecal junction was noted...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29961407/maternal-and-neonatal-outcomes-following-expectant-management-of-preterm-prelabour-rupture-of-membranes-before-viability
#19
Winnie Huiyan Sim, Hamon Ng, Penelope Sheehan
PURPOSE: To provide centre-based outcome data on obstetric and neonatal complications arising from expectantly managed pregnancies affected by preterm prelabour rupture of membranes (PPROM) before viability. MATERIALS AND METHODS: We collected data on 130 consecutive pregnancies complicated by spontaneous rupture of membranes before 24 weeks gestation, occurring over a 7-year period. These were women who delivered > 24 hours after membrane rupture, and had no signs of chorioamnionitis or advanced labour at admission...
July 1, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29940626/morphological-and-ultrasound-findings-in-the-placenta-of-diabetic-pregnancy
#20
Costin Berceanu, Adrian Victor Tetileanu, Anca Maria Ofiţeru, Elvira Brătilă, Claudia Mehedinţu, Nicoleta Loredana Voicu, Florin Adrian Szasz, Sabina Berceanu, Simona Vlădăreanu, Dan Bogdan Navolan
The purpose of this study is to analyze the morphological, histological, immunohistochemical and ultrasound findings in the placenta of maternal type 1 and gestational diabetes, to compare the pathological changes of the placental structure in the two types of metabolic disruptions, but also to establish correlations with the expression of these findings, influenced by different associated conditions. This multicenter study includes 53 pregnancies, of which 37 with pregestational and 16 with gestational diabetes...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
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