Ying Zhao, Hou-Zhi Yang, Huinan Li, Shuang Liang, Meng Wang, Chun-Di Li, Donghai Zhuo, Feifei Fan, Miao Guo, Xinxin Lv, Lingzhu Zhang, Xu Chen, Shan-Shan Li, Xin Jin
Statins, widely prescribed for cholesterol management by inhibiting HMG-CoA reductase in the cholesterol biosynthesis pathway, may also influence vertebrate development. In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM)...
March 22, 2024: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP