keyword
https://read.qxmd.com/read/38535075/anterior-scleral-thickness-and-anterior-segment-biometrics-measured-with-swept-source-ocular-coherence-tomography-in-high-myopic-eyes-with-and-without-glaucoma-a-comparative-study
#1
JOURNAL ARTICLE
Bachar Kudsieh, Rocio Vega-González, Sofia Bryan, Elena Almazan-Alonso, Mariluz Puertas, Lucia Gutiérrez-Martin, Ignacio Flores-Moreno, Jorge Ruiz-Medrano, Muhsen Samaan, Jose Maria Ruiz-Moreno
Background : To assess the anterior scleral thickness (AST), Schlemm's canal diameter (SCD), trabecular meshwork diameter (TMD) and conjunctiva tenon capsule thickness (CTT) in high myopic (HM) subjects and HM subjects with glaucoma (HMG) compared to control eyes. Methods: One hundred and twenty eyes were included, and AST at 0, 1, 2 and 3 mm from the scleral spur, SCD, TMD and CTT were measured. Results : Mean age was 64.2 ± 11.0 years, and the temporal SCD and temporal TMD were significantly longer in the HMG subjects compared to the controls (380...
March 20, 2024: Diagnostics
https://read.qxmd.com/read/38531334/drug-target-mendelian-randomization-study-of-pcsk9-and-hmg-coa-reductase-inhibition-and-atrial-fibrillation
#2
JOURNAL ARTICLE
Fuyuan Li, Yibin Mei, Qiongbi Wu, Xianjun Wu
INTRODUCTION: Atrial fibrillation (AF) is a prevalent cardiac arrhythmia with significant clinical implications. The potential influence of lipid-lowering therapies, specifically PCSK9 inhibitors (PCSK9i) and HMG-CoA reductase inhibitors (statins), on AF risk remains a topic of interest. This Mendelian Randomization (MR) study aimed to elucidate the causal relationship between genetically predicted inhibition of PCSK9 and HMG-CoA reductase and the risk of AF. METHODS: Utilizing publicly available, summary-level genome-wide association study (GWAS) data, we employed single-nucleotide polymorphisms (SNPs) associated with lower LDL-C levels as instruments for gene-simulated inhibition of PCSK9 and HMG-CoA reductase...
March 26, 2024: Cardiology
https://read.qxmd.com/read/38527035/hmgr-and-chs-gene-cloning-characterizations-and-tissue-specific-expressions-in-polygala-tenuifolia-willd
#3
JOURNAL ARTICLE
Yang Liu, Xiaofang Ma, Fuying Mao, Jinmiao Qiu, Jingyi Bi, Xiaowei Li, Xian Gu, Yuguang Zheng, Yunsheng Zhao
Triterpenoid saponins and flavonoids have several pharmacological activities against P. tenuifolia. The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) and chalcone synthase (CHS) are the rate-limiting enzymes of triterpenoid saponin and flavonoid biosynthesis, respectively. In this study, HMGR and CHS genes were cloned from P. tenuifolia, and their bioinformatics analyses and tissue-specific expression were investigated. The results showed that the HMGR and CHS genes were successfully cloned, separately named the PtHMGR gene (NCBI accession: MK424118) and PtCHS gene (NCBI accession: MK424117)...
2024: PloS One
https://read.qxmd.com/read/38523609/analyzing-the-causal-relationship-between-lipid-lowering-drug-target-genes-and-epilepsy-a-mendelian-randomization-study
#4
JOURNAL ARTICLE
Shicun Huang, Yuan Liu, Yi Zhang, Yiqing Wang, Ya Gao, Runnan Li, Lidong Yu, Xiaowei Hu, Qi Fang
BACKGROUND: Previous research has yielded conflicting results on the link between epilepsy risk and lipid-lowering medications. The aim of this study is to determine whether the risk of epilepsy outcomes is causally related to lipid-lowering medications predicted by genetics. METHODS: We used genetic instruments as proxies to the exposure of lipid-lowering drugs, employing variants within or near genes targeted by these drugs and associated with low-density lipoprotein cholesterol (LDL cholesterol) from a genome-wide association study...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38522713/early-statin-exposure-influences-cardiac-and-skeletal-development-with-implications-for-ion-channel-transcriptomes-in-zebrafish
#5
JOURNAL ARTICLE
Ying Zhao, Hou-Zhi Yang, Huinan Li, Shuang Liang, Meng Wang, Chun-Di Li, Donghai Zhuo, Feifei Fan, Miao Guo, Xinxin Lv, Lingzhu Zhang, Xu Chen, Shan-Shan Li, Xin Jin
Statins, widely prescribed for cholesterol management by inhibiting HMG-CoA reductase in the cholesterol biosynthesis pathway, may also influence vertebrate development. In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM)...
March 22, 2024: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://read.qxmd.com/read/38522316/diterpenoid-honatisine-overcomes-temozolomide-resistance-in-glioblastoma-by-inducing-mitonuclear-protein-imbalance-through-disruption-of-tfam-mediated-mtdna-transcription
#6
JOURNAL ARTICLE
Zongyang Li, Ke Sai, Guoxu Ma, Fanfan Chen, Xudong Xu, Lei Chen, Sicen Wang, Weiping Li, Guodong Huang, Ping Cui
BACKGROUND: Glioblastoma (GBM) represents as the most formidable intracranial malignancy. The systematic exploration of natural compounds for their potential applications in GBM therapy has emerged as a pivotal and fruitful avenue of research. PURPOSE: In the present study, a panel of 96 diterpenoids was systematically evaluated as a repository of potential antitumour agents. The primary objective was to discern their potency in overcoming resistance to temozolomide (TMZ)...
December 29, 2023: Phytomedicine
https://read.qxmd.com/read/38520741/pah-deficient-pathology-in-humanized-c-1066-11g-a-phenylketonuria-mice
#7
JOURNAL ARTICLE
Ainhoa Martínez-Pizarro, Sara Picó, Arístides López-Márquez, Claudia Rodriguez-López, Elena Montalvo, Mar Alvarez, Margarita Castro, Santiago Ramón-Maiques, Belén Pérez, José J Lucas, Eva Richard, Lourdes R Desviat
We have generated using CRISPR/Cas9 technology a partially humanized mouse model of the neurometabolic disease phenylketonuria (PKU), carrying the highly prevalent PAH variant c.1066-11G>A. This variant creates an alternative 3' splice site, leading to the inclusion of 9 nucleotides coding for 3 extra amino acids between Q355 and Y356 of the protein. Homozygous Pah c.1066-11A mice, with a partially humanized intron 10 sequence with the variant, accurately recapitulate the splicing defect and present almost undetectable hepatic PAH activity...
March 23, 2024: Human Molecular Genetics
https://read.qxmd.com/read/38520738/real-world-evidence-risdiplam-in-a-patient-with-spinal-muscular-atrophy-type-i-with-a-novel-splicing-mutation-and-one-smn2-copy
#8
JOURNAL ARTICLE
Kai Ma, Kaihui Zhang, Defang Chen, Chuan Wang, Mohnad Abdalla, Haozheng Zhang, Rujin Tian, Yang Liu, Li Song, Xinyi Zhang, Fangfang Liu, Guohua Liu, Dong Wang
Spinal muscular atrophy (SMA), which results from the deletion or/and mutation in the SMN1 gene, is an autosomal recessive neuromuscular disorder that leads to weakness and muscle atrophy. SMN2 is a paralogous gene of SMN1. SMN2 copy number affects the severity of SMA, but its role in patients treated with disease modifying therapies is unclear. The most appropriate individualized treatment for SMA has not yet been determined. Here, we reported a case of SMA type I with normal breathing and swallowing function...
March 23, 2024: Human Molecular Genetics
https://read.qxmd.com/read/38517996/mechanisms-underlying-the-therapeutic-effects-of-xiaoyaosan-in-treating-hyperplasia-of-mammary-glands-based-on-network-pharmacology
#9
JOURNAL ARTICLE
Peizhe Li, Yuxing Tai, Long Zhang, Sixian Wang, Qifan Guan, Xin Li, Shaowei Liu, Mingjun Liu
This study utilized network pharmacology to investigate the effects of Xiaoyaosan (XYS) on the intervention of hyperplasia of mammary glands (HMG) by targeting specific genes and signaling pathways. The active ingredients and targets of XYS, which consisted of 8 traditional Chinese medicines (TCM), were identified using TCMSP. The gene targets associated with HMG were obtained from the GeneCards Database, and the intersection data between the 2 was integrated. Cytoscape 3.8.1 software was used to construct a network diagram illustrating the relationship between compounds, drug active ingredients, target proteins, and the disease...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38513732/role-of-interleukin-6-signaling-pathway-in-the-anti-inflammatory-effects-of-statins-on-coronary-artery-disease-evidence-from-mendelian-randomization-analysis
#10
JOURNAL ARTICLE
Mojgan Yazdanpanah, Nahid Yazdanpanah, Mojtaba Chardoli, Abbas Dehghan
BACKGROUND: Statins are currently widely used in the prevention of coronary artery disease (CAD) primarily for lipid-lowering with a potential anti-inflammatory effect. However, it is not clear if their potential anti-inflammatory effects are mediated through the interleukin 6 (IL-6) signaling pathway. METHODS: Using the Mendelian randomization (MR) approach followed by multivariable MR analyses, we examined the extent to which the effects of statins on CAD might be mediated through the IL-6 signaling pathway...
March 19, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38513029/repeated-co-option-of-hmg-box-genes-for-sex-determination-in-brown-algae-and-animals
#11
JOURNAL ARTICLE
Rémy Luthringer, Morgane Raphalen, Carla Guerra, Sébastien Colin, Claudia Martinho, Min Zheng, Masakazu Hoshino, Yacine Badis, Agnieszka P Lipinska, Fabian B Haas, Josué Barrera-Redondo, Vikram Alva, Susana M Coelho
In many eukaryotes, genetic sex determination is not governed by XX/XY or ZW/ZZ systems but by a specialized region on the poorly studied U (female) or V (male) sex chromosomes. Previous studies have hinted at the existence of a dominant male-sex factor on the V chromosome in brown algae, a group of multicellular eukaryotes distantly related to animals and plants. The nature of this factor has remained elusive. Here, we demonstrate that an HMG-box gene acts as the male-determining factor in brown algae, mirroring the role HMG-box genes play in sex determination in animals...
March 22, 2024: Science
https://read.qxmd.com/read/38512067/correction-to-atp13a2-park9-regulates-endo-lysosomal-cargo-sorting-and-proteostasis-through-a-novel-pi-3-5-p2-mediated-scaffolding-function
#12
(no author information available yet)
No abstract text is available yet for this article.
March 21, 2024: Human Molecular Genetics
https://read.qxmd.com/read/38511726/correction-to-exon-specific-u1-snrnas-improve-elp1-exon-20-definition-and-rescue-elp1-protein-expression-in-a-familial-dysautonomia-mouse-model
#13
(no author information available yet)
No abstract text is available yet for this article.
March 21, 2024: Human Molecular Genetics
https://read.qxmd.com/read/38509914/ligands-of-hmg-like-dorsal-switch-protein-1-of-spodoptera-exigua-leads-to-mortality-in-diamondback-moth-plutella-xylostella
#14
JOURNAL ARTICLE
Md Mahi Imam Mollah
HMG-like dorsal switch protein 1 (DSP1) is the insect homolog of the high mobility group box 1 (HMGB1) protein of the vertebrates. Previous studies confirmed DSP1 in Spodoptera exigua , Tenebrio molitor , and Aedes albopictus, and were analyzed for their immune roles, survivability, and binding affinity with entomopathogenic bacterial metabolites. The present study aimed to predict, and confirm DSP1 in diamondback moth, Plutella xylostella along with the effect of Spodoptera exigua DSP1 ligands in the survivability of this insect...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38507070/plasticity-and-structural-alterations-of-mitochondria-and-sarcoplasmic-organelles-in-muscles-of-mice-deficient-in-%C3%AE-dystrobrevin-a-component-of-the-dystrophin-glycoprotein-complex
#15
JOURNAL ARTICLE
Saad O Malik, Alissa Wierenga, Chenlang Gao, Mohammed Akaaboune
The dystrophin-glycoprotein complex (DGC) plays a crucial role in maintaining the structural integrity of the plasma membrane and the neuromuscular junction. In this study, we investigated the impact of the deficiency of α-dystrobrevin (αdbn), a component of the DGC, on the homeostasis of intracellular organelles, specifically mitochondria and the sarcoplasmic reticulum (SR). In αdbn deficient muscles, we observed a significant increase in the membrane-bound ATP synthase complex levels, a marker for mitochondria in oxidative muscle fiber types compared to wild-type...
March 20, 2024: Human Molecular Genetics
https://read.qxmd.com/read/38507061/identification-of-caf-related-lncrnas-at-the-pan-cancer-level-represents-a-potential-carcinogenic-risk
#16
JOURNAL ARTICLE
Mingwei Wang, Minghui Jiang, Aimin Xie, Nan Zhang, Yan Xu
Cancer-associated fibroblasts (CAFs) are increasingly recognized as playing a crucial role in regulating cancer progression and metastasis. These cells can be activated by long non-coding RNAs (lncRNAs), promoting the malignant biological processes of tumor cells. Therefore, it is essential to understand the regulatory relationship between CAFs and lncRNAs in cancers. Here, we identified CAF-related lncRNAs at the pan-cancer level to systematically predict their potential regulatory functions. The identified lncRNAs were also validated using various external data at both tissue and cellular levels...
March 20, 2024: Human Molecular Genetics
https://read.qxmd.com/read/38504621/construction-and-regulation-of-the-abscisic-acid-biosynthesis-pathway-in-yarrowia-lipolytica
#17
JOURNAL ARTICLE
Lilu Liu, Kaiyuan Zhao, Zhen Liu
Abscisic acid (ABA) is an important plant hormone with a variety of physiological functions such as regulating plant growth and helping plants to resist an adverse growth environment. However, at present, the ABA yield of heterologous biosynthesis by metabolic engineering is still low for industrial production. Therefore, five Botrytis cinerea genes ( bcaba1 , bcaba2 , bcaba3 , bcaba4, and bccpr1 ) related to ABA biosynthesis were expressed in Yarrowia lipolytica PO1h; its ABA production was 24.33 mg/L. By increasing the copy number of IDI and ERG12S , ERG20Y MT , and bcaba3 , bcaba1 genes, the yield of ABA was increased to 54...
March 20, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38500815/-in-vitro-and-in-silico-studies-of-the-potential-cytotoxic-antioxidant-and-hmg-coa-reductase-inhibitory-effects-of-chitin-from-indonesia-mangrove-crab-scylla-serrata-shells
#18
JOURNAL ARTICLE
Inarah Fajriaty, Irda Fidrianny, Neng Fisheri Kurniati, Norsyahida Mohd Fauzi, Sarmila Hanim Mustafa, I Ketut Adnyana
This study aimed to characterize chitin extracted from Indonesia mangrove crab ( Scylla serrata ) shells, as well as to assess its in vitro cytotoxic, antioxidant, and HMG CoA reductase inhibitory potentials. In silico molecular docking, molecular dynamic, and ADMET prediction analyses were also carried out. Chitin was extracted from mangrove crab shells using deproteination and demineralization processes, Scanning Electron Microscopy (SEM) and Fourier Transform Infrared (FTIR) characterization are then performed...
May 2024: Saudi Journal of Biological Sciences
https://read.qxmd.com/read/38499986/multiple-congenital-granular-cell-epulis-involving-different-parts-of-the-oral-cavity-a-case-report
#19
JOURNAL ARTICLE
Yuelin Qin, Ningning Hu, Cuimei Zhang, Junwei Wang, Xuecai Yang
Congenital granular cell epulis (CGCE) is a rare disease, particularly when it affects multiple oral and maxillofacial regions. We present the case of a female neonate with 4 asymptomatic masses attached to the maxillary and mandibular gingiva as well as the tongue. Due to the size of the masses causing feeding and respiratory difficulties, lesion removal was performed under general anesthesia. Histopathological analysis revealed tightly arranged polygonal cells with abundant granular eosinophilic cytoplasm...
March 18, 2024: Ear, Nose, & Throat Journal
https://read.qxmd.com/read/38499742/the-effects-of-cholesterol-and-statins-on-parkinson-s-neuropathology-a-narrative-review
#20
REVIEW
Hayder M Al-Kuraishy, Esraa H Fahad, Salah Al-Windy, Suzy A El-Sherbeni, Walaa A Negm, Gaber El-Saber Batiha
Parkinson disease (PD) is chronic and progressive neurodegenerative disease of the brain characterized by motor symptoms including tremors, rigidity, postural instability, and bradykinesia. PD neuropathology is due to the progressive degeneration of dopaminergic neurons in the substantia nigra and accumulation of Lewy bodies in the survival neurons. The brain contains a largest amount of cholesterol which is mainly synthesized from astrocytes and glial cells. Cholesterol is intricate in the pathogenesis of PD and may be beneficial or deleterious...
March 18, 2024: Inflammopharmacology
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