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Hadis Dashtestani, Rachel Zaragoza, Hamed Pirsiavash, Kristine M Knutson, Riley Kermanian, Joy Cui, J Douglas Harrison, Milton Halem, Amir Gandjbakhche
Individuals differ in the extent to which they make decisions in different moral dilemmas. In this study, we investigated the relationship between functional brain activities during moral decision making and psychopathic personality traits in a healthy population. We measured the hemodynamic activities of the brain by functional near-infrared spectroscopy (fNIRS). FNIRS is an evolving non-invasive neuroimaging modality which is relatively inexpensive, patient friendly and robust to subject movement. Psychopathic traits were evaluated through a self-report questionnaire called the Psychopathic Personality Inventory Revised (PPI-R)...
October 18, 2018: Behavioural Brain Research
Candace Doepker, Kara Franke, Esther Myers, Jeffrey J Goldberger, Harris R Lieberman, Charles O'Brien, Jennifer Peck, Milton Tenenbein, Connie Weaver, Daniele Wikoff
In 2016⁻2017, we conducted and published a systematic review on caffeine safety that set out to determine whether conclusions that were presented in the heavily cited Health Canada assessment, remain supported by more recent data. To that end, we reviewed data from 380 studies published between June 2001 and June 2015, which were identified from an initial batch of over 5000 articles through a stringent search and evaluation process. In the current paper, we use plain language to summarize our process and findings, with the intent of sharing additional context for broader reach to the general public...
October 18, 2018: Nutrients
Rebeca Buzzo Feltrin, Maria Cristina Rodrigues Guilam, Manoel Barral-Netto, Nísia Trindade Lima, Milton Ozório Moraes
Public policy planning associated with the management of the Science, Technology, and Innovation is decisive to improve public health. It is important to develop novel strategies to plan, supervise, manage, use and evaluate research using indicators that extrapolates metrics in current use. In 2011, the Brazilian government introduced the Brazil Without Extreme Poverty plan (BWEP) that aimed to integrate several conditional cash transfer programs (CCT). The original that aimed to integrate of the CCTs were expanded in order to integrate social justice and dignity that induced several actions towards the promotion of social development of the beneficiaries...
2018: PloS One
Craig White, Milton C Weinstein, Abbey L Fingeret, Gregory W Randolph, Akira Miyauchi, Yasuhiro Ito, Tiannan Zhan, Ayman Ali, G Scott Gazelle, Carrie C Lubitz
OBJECTIVE: To assess relative clinical and economic performance of the revised American Thyroid Association (ATA) thyroid cancer guidelines compared to current standard of care. BACKGROUND: Diagnosis of thyroid cancer in the United States has tripled whereas mortality has only marginally increased. Most patients present with small papillary carcinomas and have historically received at least a total thyroidectomy as a treatment. In 2015, the ATA released the revised guidelines recommending an option for active surveillance (AS) of small papillary thyroid carcinoma and thyroid lobectomy for larger unifocal tumors...
October 17, 2018: Annals of Surgery
Renato Fraga Righetti, Tabata Maruyama Dos Santos, Leandro do Nascimento Camargo, Luciana Ritha Cássia Rolim Barbosa Aristóteles, Silvia Fukuzaki, Flávia Castro Ribas de Souza, Fernanda Paula Roncon Santana, Marcus Vinicius Rodrigues de Agrela, Maysa Mariana Cruz, Maria Isabel Cardoso Alonso-Vale, Isabella Santos Genaro, Beatriz Mangueira Saraiva-Romanholo, Edna Aparecida Leick, Milton de Arruda Martins, Carla Máximo Prado, Iolanda de Fátima Lopes Calvo Tibério
Introduction: T helper 17 (Th17) has been implicated in a variety of inflammatory lung and immune system diseases. However, little is known about the expression and biological role of IL-17 in acute lung injury (ALI). We investigated the mechanisms involved in the effect of anti-IL17 in a model of lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. Methods: Mice were pre-treated with anti-IL17, 1h before saline/LPS intratracheal administration alongside non-treated controls and levels of exhaled nitric oxide (eNO), cytokine expression, extracellular matrix remodeling and oxidative stress, as well as immune cell counts in bronchoalveolar lavage fluid (BALF), and respiratory mechanics were assessed in lung tissue...
2018: Frontiers in Pharmacology
Pablo Augusto de Souza Fonseca, Samir Id-Lahoucine, Antonio Reverter, Juan F Medrano, Marina S Fortes, Joaquim Casellas, Filippo Miglior, Luiz Brito, Maria Raquel S Carvalho, Flávio S Schenkel, Loan T Nguyen, Laercio R Porto-Neto, Milton G Thomas, Angela Cánovas
The identification of biological processes related to the regulation of complex traits is a difficult task. Commonly, complex traits are regulated through a multitude of genes contributing each to a small part of the total genetic variance. Additionally, some loci can simultaneously regulate several complex traits, a phenomenon defined as pleiotropy. The lack of understanding on the biological processes responsible for the regulation of these traits results in the decrease of selection efficiency and the selection of undesirable hitchhiking effects...
2018: PloS One
Hugo de L Corrêa, Heitor S Ribeiro, Áthila T D Maya, Rodrigo P Neves, Milton R de Moraes, Ricardo M Lima, Otávio T Nóbrega, Aparecido P Ferreira
de L. Corrêa, H, Ribeiro, HS, Maya, ÁTD, Neves, RP, de Moraes, MR, Lima, RM, Nóbrega, OT, and Ferreira, AP. Influence of the ACTN3 genotype and the exercise intensity on the respiratory exchange ratio and excess oxygen consumption after exercise. J Strength Cond Res XX(X): 000-000, 2018-This study aimed to assess the respiratory exchange ratio (RER) and excess postexercise oxygen consumption (EPOC) after high-intensity interval training and continuous moderate-intensity aerobic training in accordance with the ACTN3 genotype...
October 17, 2018: Journal of Strength and Conditioning Research
Pamela Scorza, Yuri Cutipe, Maria Mendoza, César Arellano, Jerome T Galea, Milton L Wainberg
Peru secured a legislative advance for mental health care with a 2012 law mandating that mental health services be available in primary care. One of the main challenges faced by this reform is implementation in remote regions. This column describes a pilot project in Peru that took place from 2010 to 2014 to develop capacity for including mental health services in primary care in one of the most isolated, high-needs regions of the country. The authors describe use of accompaniment-based training and supervision of clinicians and comprehensive, engaged regional partnerships formed to increase the impact and sustainability of the service expansion...
October 18, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
Takahiro Kodama, Jing Yi, Justin Y Newberg, Jean C Tien, Hao Wu, Milton J Finegold, Michiko Kodama, Zhubo Wei, Takeshi Tamura, Tetsuo Takehara, Randy L Johnson, Nancy A Jenkins, Neal G Copeland
Nonalcoholic fatty liver disease (NAFLD) is the fastest rising cause of hepatocellular carcinoma (HCC) in Western countries; however, the molecular mechanisms that cause NAFLD-HCC remain elusive. To identify molecular drivers of NAFLD-HCC, we performed Sleeping Beauty (SB) transposon mutagenesis screens in liver-specific Pten knockout and in high-fat diet-fed mice, which are murine models of NAFLD-HCC. SB mutagenesis accelerated liver tumor formation in both models and identified 588 and 376 candidate cancer genes (CCGs), respectively; 257 CCGs were common to both screens and were enriched in signaling pathways known to be important for human HCC...
October 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
Milton Saute
No abstract text is available yet for this article.
October 2018: Israel Medical Association Journal: IMAJ
Daniel Pecoraro Demarque, Rui Milton Patrício Silva, Leandro Figueiredo Santos, Andréia Machado Leopoldino, Enilza Maria Espreafico, Norberto Peporine Lopes
The purpose of this contribution is to evaluate the cytotoxicity and apoptosis inducing ability of structurally diverse anthraquinones to establish a relationship between structure and toxicity. Besides the wide spread use of anthraquinones in pharmacological drugs for constipation and non-prescription dietary supplements for weight loss, extracts are still commercialized as crude extracts and long-term side effects are still relevant. In this work we developed a method to quantify the cascarosides isolated from Rhamnus purshiana (Cascara Sagrada) using LC-MS/MS and evaluated the effects of this extract and isolated compounds on cellular viability using NOK-SI, HeLa, and T98G cell lineages...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
Rodrigo San-Martin, Maria Inês Zimiani, Claudemiro Noya, Milton Augusto Vendramini Ávila, Rosana Shuhama, Cristina Marta Del-Ben, Paulo Rossi Menezes, Francisco José Fraga, Cristiane Salum
Prepulse inhibition (PPI) test has been widely used to evaluate sensorimotor gating. In humans, deficits in this mechanism are measured through the orbicularis muscle response using electromyography (EMG). Although this mechanism can be modulated by several brain structures and is impaired in some pathologies as schizophrenia and bipolar disorder, neural PPI evaluation is rarely performed in humans. Since eye blinks are a consequence of PPI stimulation, they strongly contaminate the electroencephalogram (EEG) signal...
2018: Frontiers in Neuroscience
Laurence Culot, Lucas Augusto Pereira, Ilaria Agostini, Marco Antônio Barreto de Almeida, Rafael Souza Cruz Alves, Izar Aximoff, Alex Bager, María Celia Baldovino, Thiago Ribas Bella, Júlio César Bicca-Marques, Caryne Braga, Carlos Rodrigo Brocardo, Ana Kellen Nogueira Campelo, Gustavo R Canale, Jader da Cruz Cardoso, Eduardo Carrano, Diogo Cavenague Casanova, Camila Righetto Cassano, Erika Castro, Jorge José Cherem, Adriano Garcia Chiarello, Braz Antonio Pereira Cosenza, Rodrigo Costa-Araújo, Nilmara Cristina da Silva, Mario S Di Bitetti, Aluane Silva Ferreira, Priscila Coutinho Ribas Ferreira, Marcos de S Fialho, Lisieux Franco Fuzessy, Guilherme Siniciato Terra Garbino, Francini de Oliveira Garcia, Cassiano A F R Gatto, Carla Cristina Gestich, Pablo Rodrigues Gonçalves, Nila Rássia Costa Gontijo, Maurício Eduardo Graipel, Carlos Eduardo Guidorizzi, Robson Odeli Espíndola Hack, Gabriela Pacheco Hass, Renato Richard Hilário, André Hirsch, Ingrid Holzmann, Daniel Henrique Homem, Hilton Entringer Júnior, Gilberto Sabino-Santos Júnior, Maria Cecília Martins Kierulff, Christoph Knogge, Fernando Lima, Elson Fernandes de Lima, Cristiana Saddy Martins, Adriana Almeida de Lima, Alexandre Martins, Waldney Pereira Martins, Fabiano R de Melo, Ricardo Melzew, João Marcelo Deliberador Miranda, Flávia Miranda, Andréia Magro Moraes, Tainah Cruz Moreira, Maria Santina de Castro Morini, Mariana B Nagy-Reis, Luciana Oklander, Leonardo de Carvalho Oliveira, Adriano Pereira Paglia, Anderson Pagoto, Marcelo Passamani, Fernando de Camargo Passos, Carlos A Peres, Michell Soares de Campos Perine, Míriam Plaza Pinto, Antonio Rossano Mendes Pontes, Marcio Port Carvalho, Bárbara Heliodora Soares do Prado, André Luis Regolin, Gabriela Cabral Rezende, Alessandro Rocha, Joedison Dos S Rocha, Raisa Reis de Paula Rodarte, Lilian Patrícia Sales, Edmilson Dos Santos, Paloma Marques Santos, Christine Steiner São Bernardo, Ricardo Sartorello, Leonardo La Serra, Eleonore Setz, Anne Sophie de Almeida E Silva, Leonardo Henrique da Silva, Pedro Bencke Ermel da Silva, Maurício Silveira, Rebecca L Smith, Sara Machado de Souza, Ana Carolina Srbek-Araujo, Leonardo Carreira Trevelin, Claudio Valladares Padua, Luciana Zago, Eduardo Marques, Stephen Francis Ferrari, Raone Beltrão-Mendes, Denison José Henz, Francys E da Veiga da Costa, Igor Kintopp Ribeiro, Lucas Lacerda Toth Quintilham, Marcos Dums, Pryscilla Moura Lombardi, Renata Twardowsky Ramalho Bonikowski, Stéfani Gabrieli Age, João Pedro Souza-Alves, Renata Chagas, Rogério Grassetto Teixeira da Cunha, Monica Mafra Valença-Montenegro, Gabriela Ludwig, Leandro Jerusalinsky, Gerson Buss, Renata Bocorny de Azevedo, Roberio Freire Filho, Felipe Bufalo, Louis Milhe, Mayara Mulato Dos Santos, Raíssa Sepulvida, Daniel da Silva Ferraz, Michel Barros Faria, Milton Cezar Ribeiro, Mauro Galetti
Primates play an important role in ecosystem functioning and offer critical insights into human evolution, biology, behavior, and emerging infectious diseases. There are 26 primate species in the Atlantic Forests of South America, 19 of them endemic. We compiled a dataset of 5,472 georeferenced locations of 26 native and 1 introduced primate species, as hybrids in the genera Callithrix and Alouatta. The dataset includes 700 primate communities, 8,121 single species occurrences and 714 estimates of primate population sizes, covering most natural forest types of the tropical and subtropical Atlantic Forest of Brazil, Paraguay and Argentina and some other biomes...
October 13, 2018: Ecology
Milton L Wainberg, Liat Helpman, Cristiane S Duarte, Sten H Vermund, Jennifer J Mootz, Lidia Gouveia, Maria A Oquendo, Karen McKinnon, Francine Cournos
Although psychiatric disorders are classified as non-communicable diseases, we believe this classification is too rigid and limiting. We present evidence of the communicability of psychiatric disorders through three major pathways: infectious and ecological, familial, and sociocultural communicability. Successful strategies developed to control the spread of communicable infectious diseases are relevant to curtailing the communicability of psychiatric disorders, thereby reducing their burden. Current interventions and policies that conceptualise psychiatric illnesses as non-communicable mostly focus on the individual...
October 10, 2018: Lancet Psychiatry
Catherine Carlson, Annika Sweetland, Milton Wainberg
No abstract text is available yet for this article.
October 9, 2018: Lancet Psychiatry
Milton Tan, Jonathan W Armbruster
The order Cypriniformes is the most diverse order of freshwater fishes. Recent phylogenetic studies have approached a consensus on the phylogenetic relationships of Cypriniformes and proposed a new phylogenetic classification of family-level groupings in Cypriniformes. The lack of a reference for the placement of genera amongst families has hampered the adoption of this phylogenetic classification more widely. We herein provide an updated compilation of the membership of genera to suprageneric taxa based on the latest phylogenetic classifications...
September 13, 2018: Zootaxa
D L Hoffmann, C D Standish, M García-Diez, P B Pettitt, J A Milton, J Zilhão, J J Alcolea-González, P Cantalejo-Duarte, H Collado, R de Balbín, M Lorblanchet, J Ramos-Muñoz, G-Ch Weniger, A W G Pike
Slimak et al challenge the reliability of our oldest (>65,000 years) U-Th dates on carbonates associated with cave paintings in Spain. They cite a supposed lack of parietal art for the 25,000 years following this date, along with potential methodological issues relating to open-system behavior and corrections to detrital or source water 230 Th. We show that their criticisms are unfounded.
October 12, 2018: Science
Milton O Aguilera, Laura R Delgui, Patricia S Romano, María I Colombo
Multiple tissues and systems in the organism undergo modifications during aging due to an accumulation of damaged proteins, lipids, and genetic material. To counteract this process, the cells are equipped with specific mechanisms, such as autophagy and senescence. Particularly, the immune system undergoes a process called immunosenescence, giving rise to a chronic inflammatory status of the organism, with a decreased ability to counteract antigens. The obvious result of this process is a reduced defence capacity...
October 10, 2018: Cells
Milton Llera-Montero, João Sacramento, Rui Ponte Costa
The probabilistic nature of synaptic transmission has remained enigmatic. However, recent developments have started to shed light on why the brain may rely on probabilistic synapses. Here, we start out by reviewing experimental evidence on the specificity and plasticity of synaptic response statistics. Next, we overview different computational perspectives on the function of plastic probabilistic synapses for constrained, statistical and deep learning. We highlight that all of these views require some form of optimisation of probabilistic synapses, which has recently gained support from theoretical analysis of long-term synaptic plasticity experiments...
October 8, 2018: Current Opinion in Neurobiology
Velia Margarita Cárdenas Villarreal, Rosario Edith Ortiz Félix, Ernesto Cortés-Castell, Patricia Edina Miranda Félix, Milton Carlos Guevara Valtier, María Mercedes Rizo-Baeza
INTRODUCTION: despite the fact that childhood obesity is a serious health problem, little is known about its related factors in early childhood. OBJECTIVE: to evaluate which maternal, cognitive and infant factors influence the infant's energy intake and if these influence their nutritional status before the year. METHODS: descriptive study of correlation. Two hundred and sixty-seven dyads (mother/child) participated. The questionnaires consisted of four instruments for the cognitive variables of the mother (maternal self-efficacy, attitude in the diet, perception of signs of hunger, satiety and weight of the child), energy intake through a 24-hour reminder and sociodemographic and anthropometric data of the mother and child, through which maternal body mass index (BMI) and Z-score of infant weight/height have been calculated...
October 5, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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