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Felipe Berti Valer, Maiaro Cabral Rosa Machado, Rui Milton Patrício Silva-Junior, Ricardo Guelerman Pinheiro Ramos
The Irre Cell-Recognition Module (IRM) is a group of evolutionarily conserved and structurally related transmembrane glycoproteins of the immunoglobulin superfamily. In Drosophila melanogaster it comprises the products of the genes roughest (rst; also known as irreC-rst), kin-of-irre (kirre; also known as duf), stick-and-stones (sns) and hibris (hbs). In this model organism, the behavior of this group of proteins as a partly redundant functional unit mediating selective cell recognition was demonstrated in a variety of developmental contexts, but their possible involvement in ovarian development and oogenesis has not been investigated, notwithstanding the fact that some rst mutant alleles are also female sterile...
August 16, 2018: Genesis: the Journal of Genetics and Development
Aline de Matos Valerio, Milton Kampel, Vincent Vantrepotte, Nicholas D Ward, Henrique Oliveira Sawakuchi, Diani Fernanda Da Silva Less, Vania Neu, Alan Cunha, Jeffrey Richey
Coloured dissolved organic matter (CDOM) is one of the major contributors to the absorption budget of most freshwaters and can be used as a proxy to assess non-optical carbon fractions such as dissolved organic carbon (DOC) and the partial pressure of carbon dioxide (pCO2 ). Nevertheless, riverine studies that explore the former relationships are still relatively scarce, especially within tropical regions. Here we document the spatial-seasonal variability of CDOM, DOC and pCO2 , and assess the potential of CDOM absorption coefficient (aCDOM (412)) for estimating DOC concentration and pCO2 along the Lower Amazon River...
July 9, 2018: Optics Express
Jennifer L Dumouchel, Nagendra Chemuturi, Mark N Milton, Gian Camenisch, James E Chastain, Markus Walles, Vito Sasseville, Mithat Gunduz, Ganesh Iyer, Upendra Argikar
The eye is a complex organ with a series of anatomical barriers that provide protection from physical and chemical injury while maintaining homeostasis and function. The physiology of the eye is multifaceted with dynamic flows and clearance mechanisms. This review highlights that in vitro ocular transport and metabolism models are confined by the availability of clinically relevant absorption, distribution, metabolism, and excretion (ADME) data. In vitro ocular transport models used for pharmacology and toxicity poorly predict ocular exposure...
August 15, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
Milton Packer
No abstract text is available yet for this article.
August 7, 2018: European Heart Journal
K Milton, J Chau, B McGill, A Bauman
OBJECTIVES: The media is a substantial vehicle for conveying public health messages to the public. This study examined the extent to which the publication of special issues in a high-impact medical journal in 2012 and 2016 generated media interest in physical activity and health in the UK and explored the main issues that were reported. STUDY DESIGN: This is a systematic narrative review of print media. METHODS: Relevant print news articles were identified by searching Factiva and Google News...
August 11, 2018: Public Health
Milton Halyson Benevides de Freitas, Luciana Cavalcanti Lima, Tania Cursino de Menezes Couceiro, Wilton Bernadino da Silva, João Marcelo de Andrade, Marcio Handerson Benevides de Freitas
INTRODUCTION: Successful renal transplant and consequent good graft function depend on a good surgical technique, an anesthetic that ensures the hemodynamic stability of the receiver, and appropriate conditions of graft and recipient. Several factors can interfere with the perfusion of the graft and compromise its viability. The objective of this study was to evaluate perioperative factors associated with delayed graft function (DGF) in renal transplantation patients. METHODS: This is a historical cohort study of patients who underwent renal transplantation between 2011 and 2013...
August 13, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Sonia Johnson, Danielle Lamb, Louise Marston, David Osborn, Oliver Mason, Claire Henderson, Gareth Ambler, Alyssa Milton, Michael Davidson, Marina Christoforou, Sarah Sullivan, Rachael Hunter, David Hindle, Beth Paterson, Monica Leverton, Jonathan Piotrowski, Rebecca Forsyth, Liberty Mosse, Nicky Goater, Kathleen Kelly, Mel Lean, Stephen Pilling, Nicola Morant, Brynmor Lloyd-Evans
BACKGROUND: High resource expenditure on acute care is a challenge for mental health services aiming to focus on supporting recovery, and relapse after an acute crisis episode is common. Some evidence supports self-management interventions to prevent such relapses, but their effect on readmissions to acute care following a crisis is untested. We tested whether a self-management intervention facilitated by peer support workers could reduce rates of readmission to acute care for people discharged from crisis resolution teams, which provide intensive home treatment following a crisis...
August 4, 2018: Lancet
Milton Halyson Benevides de Freitas, Luciana Cavalcanti Lima, Tania Cursino de Menezes Couceiro, Maria Célia Ferreira da Costa, Márcio Handerson Benevides de Freitas
BACKGROUND AND OBJECTIVES: Conjoined twins are monozygotic twins physically joined at some part of the body. This is a rare phenomenon, estimated between 1:50,000 to 1:200,000 births. The objective of this report is to present the anesthetic management and the perioperative challenges for a separation surgery. CASE REPORT: Thoraco-omphalopagus twins were diagnosed by ultrasound and were followed by the fetal medicine team of the service. After 11hours of cesarean, the pediatric surgical team chose to separate the twins...
August 7, 2018: Revista Brasileira de Anestesiologia
Jonathan G Eastman, Milton L Chip Routt
The superior ramus is an irregularly shaped, undulating, and curvilinear osseous structure that can provide an osseous conduit for intramedullary screws. A wide spectrum of variability between the curve and obliquity of the superior ramus osseous fixation pathway (OFP) exists in both the anteroposterior and the coronal planes. A detailed understanding of the osseous topography and how it correlates with fluoroscopic imaging is mandatory. Obtaining the correct intraoperative inlet and combined obturator oblique-outlet fluoroscopic views specific to each patient's anatomy is necessary for safe implant insertion...
September 2018: Journal of Orthopaedic Trauma
Sue Fletcher-Watson, Jon Adams, Kabie Brook, Tony Charman, Laura Crane, James Cusack, Susan Leekam, Damian Milton, Jeremy R Parr, Elizabeth Pellicano
Participatory research methods connect researchers with relevant communities to achieve shared goals. These methods can deliver results that are relevant to people's lives and thus likely to have a positive impact. In the context of a large and growing body of autism research, with continued poor implementation, and some evidence of community dissatisfaction, there is a powerful case for participatory autism research. In order to develop a framework for such collaborative working, a UK seminar series was organised and co-produced by autistic and non-autistic people with academic, practitioner and lived expertise...
August 10, 2018: Autism: the International Journal of Research and Practice
Jorge Monteiro, Fernanda Silva-Pereira, Milton Severo
BACKGROUND: Most studies on academic cheating rely on self-reported questionnaires and focus on the individual, overlooking cheating as a group activity. The aim of this study is to estimate the true prevalence of cheating/anomalies among medical students using a statistical index developed for this purpose, and to explore the existence of social networks between anomalies in students' results. METHODS: Angoff's A index was applied to a sample of 30 written examinations, with a total of 1487 students and 7403 examinations taken, from the 2014/2015 academic year of the Faculty of Medicine of the University of Porto to detect anomaly pairs...
August 9, 2018: BMC Medical Education
Irina A Rodionova, Norman Goodacre, Jimmy Do, Ali Hosseinnia, Mohan Babu, Peter Uetz, Milton H Saier
Folate derivatives are important cofactors for enzymes in several metabolic processes. Folate-related inhibition and resistance mechanisms in bacteria are potential targets for antimicrobial therapies and therefore a significant focus of current research. Here, we report that the activity of Escherichia coli poly-γ-glutamyl tetrahydrofolate/dihydrofolate synthase (FolC) is regulated by the glutamate/glutamine-sensing uridylyltransferase (GlnD), the THF-dependent tRNA modification enzyme (MnmE) and the UDP-glucose dehydrogenase (Ugd) as shown by direct in vitro protein-protein interactions...
August 8, 2018: Journal of Biological Chemistry
Brian G Southwell, Milton Eder, John Finnegan, Alan T Hirsch, Russell V Luepker, Sue Duval, Carol Russell, Sam O'Byrne
BACKGROUND: Literature on health promotion evaluation and public understanding of health suggests the importance of investigating behaviour over time in conjunction with information environment trends as a way of understanding programme impact. We analysed population response to online promotion of an educational tool built by the Ask About Aspirin campaign in the USA to inform people about aspirin as a preventive aid. METHODS: We collected 156 weeks of time series data on audience behaviour, namely use of a self-assessment tool...
August 6, 2018: Journal of Epidemiology and Community Health
Yi Zhao, Zheng-Hai Du, Milton Talukder, Jia Lin, Xue-Nan Li, Cong Zhang, Jin-Long Li
The widely used Di-(2-ethylhexyl) phthalate (DEHP) has been reported to exhibit ubiquitous environmental and global health hazards. The bioaccumulation and environmental persistence of DEHP can cause serious health hazards in wildlife animals and human. However, DEHP-induced nephrotoxicity in bird is remained unknown. Thus, this study explored the related mechanism of DEHP nephrotoxicity in quail. For this purpose, quail were exposed with DEHP at doses of 0, 250, 500, and 1000 mg/kg body weight daily by gavage administration for 45 days...
July 26, 2018: Environmental Pollution
Marcelo R V Diniz, Ana L B Paiva, Clara Guerra-Duarte, Milton Y Nishiyama, Mauricio A Mudadu, Ursula de Oliveira, Márcia H Borges, John R Yates, Inácio de L Junqueira-de-Azevedo
Phoneutria nigriventer is one of the largest existing true spiders and one of the few considered medically relevant. Its venom contains several neurotoxic peptides that act on different ion channels and chemical receptors of vertebrates and invertebrates. Some of these venom toxins have been shown as promising models for pharmaceutical or biotechnological use. However, the large diversity and the predominance of low molecular weight toxins in this venom have hampered the identification and deep investigation of the less abundant toxins and the proteins with high molecular weight...
2018: PloS One
Milton N Schroth, John J Cho, Sylvia K Green, Spyros D Kominos, Microbiology Society Publishing
A prevailing opinion is that the strains of Pseudomonas aeruginosa that infects both plants and humans are two separate species. This study strongly disputes that notion until the modern molecular technology proves otherwise. This paper examines a spectrum of strains occurring in nature, their habitats, dissemination, their relationship to clinical strains, and the environmental conditions that favor their colonization of plants. The isolates were obtained from clinical specimens, plants, soil, and water. The identity of these strains was confirmed using pyocin typing and biochemical assays...
August 2018: Journal of Medical Microbiology
Lindsay Jasperse, Milton Levin, Katherine Tsantiris, Roxanna Smolowitz, Christopher Perkins, J Evan Ward, Sylvain De Guise
Given their particle feeding behavior, sessile nature, and abundance in coastal zones, bivalves are at significant risk for exposure to oil and oil dispersant following environmental disasters like the Deepwater Horizon oil spill. However, the effects of oil combined with oil dispersants on the health of oysters are not well studied. Therefore, eastern oysters (Crassostrea virginica) were exposed in vivo to Corexit® 9500, crude oil (high-energy water accommodated fraction; HEWAF), and a Corexit® /oil mixture (chemically-enhanced water accommodated fraction; CEWAF) to evaluate potential toxic effects on immunological (phagocytosis and respiratory burst), physiological (feeding rate), and histological endpoints...
July 20, 2018: Aquatic Toxicology
Milton Packer
The heightened risk of heart failure in type 2 diabetes cannot be explained by the occurrence of clinically overt myocardial ischemic events or hyperglycemia. Experimentally, insulin exerts detrimental effects on the heart, vasculature, kidneys, and adipose tissue that can lead to heart failure. In both randomized clinical trials and observational studies, antihyperglycemic drugs that act through insulin signaling (i.e., sulfonylureas, thiazolidinediones, and incretins) increase the risk or worsen the clinical course of heart failure, whereas drugs that ameliorate hyperinsulinemia and do not signal through insulin (i...
June 2018: JACC. Basic to Translational Science
Yngrid Dieguez Ferreira, Lilian de Fatima Costa Faria, Milton Luiz Gorzoni, Thais Andrea Dos Santos Gonçalves, José Wilson Curi Frascareli Filho, Thays Helena de Abreu Lima
Background: The Brazilian elderly population is growing exponentially, making prevention and treatment of chronic diseases a priority in this age group. Anemia in older adults is underdiagnosed, undervalued and associated with high morbimortality. Objective: To assess the prevalence of anemia in the elderly residents of a long-term care institution and to correlate this with individual patient history, the use of polypharmacy and mortality. Method: A retrospective study was carried out of data extracted from medical records of patients treated in 2014 at the Hospital Geriátrico e de Convalescentes Dom Pedro II under the Preventive Actions Program...
April 2018: Hematology, transfusion and cell therapy
Marta Dias-Vaz, Hélder Morgado, Milton Severo, José Estevão-Costa
OBJECTIVE: The GBI (Glasgow Benefit Inventory) and the GCBI (Glasgow Children's Benefit Inventory) are used to evaluate patient-reported Health-Related Quality of Life (HRQoL) following otoplasty for prominent ears. The aim of this study was to validate them through patients' and caregivers' perspectives, and in Portuguese language versions. STUDY DESIGN: After translation to Portuguese, the GBI and the GCBI were applied to patients (n=255) who underwent otoplasty throughout a five-year span and to their caregivers, respectively...
July 26, 2018: Clinical Otolaryngology
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