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https://www.readbyqxmd.com/read/30537261/the-prognostic-value-of-troponin-t-and-n-terminal-pro-b-type-natriuretic-peptide-alone-and-in-combination-in-heart-failure-patients-with-and-without-diabetes
#1
Rasmus Rørth, Pardeep S Jhund, Søren L Kristensen, Akshay S Desai, Lars Køber, Jean L Rouleau, Scott D Solomon, Karl Swedberg, Michael R Zile, Milton Packer, John J V McMurray
AIMS: We examined the prognostic importance of N-terminal pro B-type natriuretic peptide (NT-proBNP) and troponin T (TnT) in heart failure patients with and without diabetes. METHODS AND RESULTS: We measured NT-proBNP and TnT in the biomarker substudy of the Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure trial (PARADIGM-HF). Of 1907 patients, 759 (40%) had diabetes. Median TnT in patients with diabetes was 18 (interquartile range 11-27) ng/L and 13 (9-21) ng/L in those without (P < 0...
December 10, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/30536678/heart-failure-with-reduced-ejection-fraction-comparison-of-patient-characteristics-and-clinical-outcomes-within-asia-and-between-asia-europe-and-the-americas
#2
Pooja Dewan, Pardeep S Jhund, Li Shen, Mark C Petrie, William T Abraham, M Atif Ali, Chen-Huan Chen, Akshay S Desai, Kenneth Dickstein, Jun Huang, Songsak Kiatchoosakun, Kee-Sik Kim, Lars Køber, Wen-Ter Lai, Yuhua Liao, Ulrik M Mogensen, Byung-Hee Oh, Milton Packer, Jean L Rouleau, Victor Shi, Antonio S Sibulo, Scott D Solomon, Piyamitr Sritara, Karl Swedberg, Hiroyuki Tsutsui, Michael R Zile, John J V McMurray
AIMS: Nearly 60% of the world's population lives in Asia but little is known about the characteristics and outcomes of Asian patients with heart failure with reduced ejection fraction (HFrEF) compared to other areas of the world. METHODS AND RESULTS: We pooled two, large, global trials, with similar design, in 13 174 patients with HFrEF (patient distribution: China 833, India 1390, Japan 209, Korea 223, Philippines 223, Taiwan 199 and Thailand 95, Western Europe 3521, Eastern Europe 4758, North America 613, and Latin America 1110)...
December 10, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/30535159/operating-at-the-very-low-end-of-the-crassulacean-acid-metabolism-cam-spectrum-sesuvium-portulacastrum-aizoaceae
#3
Klaus Winter, Milton Garcia, Aurelio Virgo, Joseph A M Holtum
Demonstration of CAM in species with low CAM-usage relative to C3-photosynthetic CO2 assimilation can be challenging experimentally but provides crucial information on the early steps of CAM evolution. Weakly-expressed CAM was detected in the well-known pantropical coastal, leaf-succulent herb Sesuvium portulacastrum (L.) L., demonstrating that CAM is present in the Sesuvioideae, the only sub-family of the Aizoaceae in which CAM had not yet been shown conclusively. In outdoor plots in Panama, leaves and stems of S...
December 7, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/30534936/-hepatitis-e-virus-seroprevalence-in-blood-donors-in-a-university-hospital-in-chile
#4
Natalia Covarrubias, Paulina Naveas, Julio Miranda, Carmen Hurtado, Daniela B Vera, Milton Larrondo, Javier Brahm, Mauricio Venegas
In Chile, there are few studies about seroprevalence of IgG antibodies against hepatitis E virus (HEV) in blood banks, between 4 and 8%. The development of new techniques with greater sensitivity and specificity, account for an increase in the seroprevalence of HEV in various countries, the current status in Chile being unknown. In the present study, we determined the seroprevalence of anti-HEV IgG in blood donors of the Clinical Hospital University of Chile, with last generation ELISA techniques. Out of a total of 186 samples, collected in 2014, 56 (30...
August 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/30533601/effect-of-internet-based-cognitive-behavioral-humanistic-and-interpersonal-training-vs-internet-based-general-health-education-on-adolescent-depression-in-primary-care-a-randomized-clinical-trial
#5
Tracy Gladstone, Daniela Terrizzi, Allison Stinson, Jennifer Nidetz, Jason Canel, Eumene Ching, Anita Berry, James Cantorna, Joshua Fogel, Milton Eder, Megan Bolotin, Lauren O Thomann, Kathy Griffith, Patrick Ip, David A Aaby, C Hendricks Brown, William Beardslee, Carl Bell, Theodore J Crawford, Marian Fitzgibbon, Linda Schiffer, Nina Liu, Monika Marko-Holguin, Benjamin W Van Voorhees
Importance: Although 13-20% of American adolescents experience a depressive episode annually, no scalable primary care model for adolescent depression prevention is currently available. Objective: To study whether CATCH-IT (Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training) reduces the hazard for depression in at-risk adolescents identified in primary care, as compared to a general health education attention control (HE)...
November 2018: JAMA network open
https://www.readbyqxmd.com/read/30533272/lateral-position-and-utility-of-navigation-for-posterior-fixation-of-unstable-cervical-fracture-with-ankylosing-spondylitis
#6
Zubair Ahammad, Jason Milton, Kailash Narayan, Victor Awuor
Background: Ankylosing spondylitis (AS) is a seronegative spondyloarthropathy within the spectrum of rheumatologic diseases. The systemic inflammation that characterizes AS leads to bone resorption and reformation. Pathologic remodeling may include kyphosis, osteoporosis, and multi-segment auto-fusion. Cervical fractures account for 53-78% of spinal trauma seen with AS. Surgical planning is often challenging owing to spinal deformity, medical comorbidities, the cervicothoracic foci of injury, and gross instability of these fracture...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/30532341/a-re-examination-of-responding-on-ratio-and-regulated-probability-interval-schedules
#7
Omar D Pérez, Michael R F Aitken, Amy L Milton, Anthony Dickinson
The higher response rates observed on ratio than on matched interval reward schedules has been attributed to the differential reinforcement of longer inter-response times (IRTs) on the interval contingency. Some data, however, seem to contradict this hypothesis, showing that the difference is still observed when the role of IRT reinforcement is neutralized by using a regulated-probability interval schedule (RPI). Given the mixed evidence for these predictions, we re-examined this hypothesis by training three groups of rats to lever press under ratio, interval and RPI schedules across two phases while matching reward rates within triads...
November 2018: Learning and Motivation
https://www.readbyqxmd.com/read/30531283/milton-thomas-edgerton-father-of-academic-plastic-surgery
#8
Gabriel F Santiago, Amir Wolff, Chad Gordon
No abstract text is available yet for this article.
December 10, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/30531279/milton-t-edgerton-md-providing-first-clues-to-our-most-unhappy-patients
#9
Mark B Constantian
No abstract text is available yet for this article.
December 10, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/30529197/%C3%AE-4%C3%AE-2-nicotinic-receptor-desensitizing-compounds-can-decrease-self-administration-of-cocaine-and-methamphetamine-in-rats
#10
Edward D Levin, Amir H Rezvani, Corinne Wells, Susan Slade, Venkata M Yenugonda, Yong Liu, Milton L Brown, Yingxian Xiao, Kenneth J Kellar
Sazetidine-A [6-(5(((S)-azetidine-2-yl)methoxy)pyridine-3-yl)hex-5-yn-1-ol] is a selective α4β2 nicotinic receptor desensitizing agent and partial agonist. Sazetidine-A has been shown in our previous studies to significantly reduce nicotine and alcohol self-administration in rats. The question arises whether sazetidine-A would reduce self-administration of other addictive drugs as well. Nicotinic receptors on the dopaminergic neurons in the ventral tegmental area play an important role in controlling the activity of these neurons and release of dopamine in the nucleus accumbens, which is critical mechanism for reinforcing value of drugs of abuse...
December 7, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/30525480/stainless-steel-column-for-robust-high-temperature-microchip-gas-chromatography
#11
Abhijit Ghosh, Austin R Foster, Carlos Vilorio, Jacob C Johnson, Luke T Tolley, Brian D Iverson, Aaron R Hawkins, H Dennis Tolley, Milton L Lee
This paper reports the first results of a robust, high performance, stainless-steel microchip gas chromatography (GC) column that is capable of analyzing complex real world mixtures as well as operating at very high temperatures. Using a serpentine design, a 10 m column with an approximately semicircular cross section with a 52 µm hydraulic diameter (Dh) was produced in a 17 cm x 6.3 cm x 0.1 cm rectangular steel chip. The channels were produced using a multilayer chemical etch and diffusion bonding process, and metal nuts were brazed onto the inlet and outlet ports allowing for column interfacing with ferrules and fused silica capillary tubing...
December 10, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/30522497/generalizing-remotely-supervised-transcranial-direct-current-stimulation-tdcs-feasibility-and-benefit-in-parkinson-s-disease
#12
Bryan Dobbs, Natalie Pawlak, Milton Biagioni, Shashank Agarwal, Michael Shaw, Giuseppina Pilloni, Marom Bikson, Abhishek Datta, Leigh Charvet
BACKGROUND: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that has been shown to improve common symptoms of neurological disorders like depressed mood, fatigue, motor deficits and cognitive dysfunction. tDCS requires daily treatment sessions in order to be effective. We developed a remotely supervised tDCS (RS-tDCS) protocol for participants with multiple sclerosis (MS) to increase accessibility of tDCS, reducing clinician, patient, and caregiver burden...
December 7, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/30522276/digital-acoustic-sensor-performance-across-the-infrasound-range-in-non-isolated-conditions
#13
Karina Asmar, Milton Garcés, Darren Hart, Brian Williams
The next generation of acoustic sensors is emerging to supplement legacy sensors traditionally used in regional and global networks. These devices operate under similar principles as traditional sensors, without the need of a separate external digitizer. The calibration of these sensors against their predecessors is crucial to the modernization of conventional technologies. This work describes the characterization of the next-generation MB3 digital microbarometer and the iPrecision smartphone microphone in a non-isolated calibration room across the infrasound (i...
November 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/30521428/effects-of-weight-loss-on-dynamic-hyperinflation-in-women-obese-asthmatics
#14
Aline Grandi Silva, Patricia Duarte Freitas, Palmira Gabriele Ferreira, Rafael Stelmach, Regina Maria Carvalho Pinto, João Marcos Salge, Mílton A Martins, Celso R F Carvalho
Obese adults with asthma are more likely to develop dynamic hyperinflation (DH) and expiratory flow limitation (EFL) than non-obese asthmatics, and weight-loss seems to improve the breathing mechanics during exercise. However, studies evaluating the effect of weight-loss on DH in obese adults with asthma have not been performed. OBJECTIVE: To evaluate the effect of a weight-loss program on DH in obese adults with asthma. METHODS: Forty-two asthma patients were enrolled in a weight-loss program (diet, psychological support and exercise) and were subsequently divided into two groups according to the percentage of weight-loss: the ≥5%group (n=19) and the &lt;5%group (n=23)...
December 6, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/30517230/over-the-counter-medications-potentially-inappropriate-for-the-elderly
#15
EDITORIAL
Milton Luiz Gorzoni, Renato Moraes Alves Fabbri
No abstract text is available yet for this article.
October 2018: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/30517169/comparative-genomics-of-transport-proteins-in-seven-bacteroides-species
#16
Hassan Zafar, Milton H Saier
The communities of beneficial bacteria that live in our intestines, the gut microbiome, are important for the development and function of the immune system. Bacteroides species make up a significant fraction of the human gut microbiome, and can be probiotic and pathogenic, depending upon various genetic and environmental factors. These can cause disease conditions such as intra-abdominal sepsis, appendicitis, bacteremia, endocarditis, pericarditis, skin infections, brain abscesses and meningitis. In this study, we identify the transport systems and predict their substrates within seven Bacteroides species, all shown to be probiotic; however, four of them (B...
2018: PloS One
https://www.readbyqxmd.com/read/30516681/ischemic-complications-after-high-grade-glioma-resection-could-interfere-with-residual-tumor-detection-with-18f-fluorocholine-pet-ct
#17
Ana María García Vicente, María José Rodriguez Muñoz, Francisco José Pena Pardo, Milton Miguel Martinez Madrigal, Angel Soriano Castrejón
Ischemic complications after resection of high-grade glioma are frequent and may constitute potential cause of false-positive results in postsurgical evaluation using F-fluorocholine PET/CT. On the other hand, hypoxia caused by ischemia promotes invasive glioma growth. We present 3 cases of patients with different grades of ischemic injury after resection of high-grade glioma. The combined interpretation of diffusion-weighted imaging and apparent diffusion coefficient map on MRI, in this clinical setting, is mandatory to avoid PET/CT misinterpretations...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30515036/personality-disorders-among-individuals-seeking-cosmetic-botulinum-toxin-type-a-bonta-injection-a-cross-sectional-study
#18
Alireza Mohebbipour Loron, Azra Ghaffari, Negin Poursafargholi
Objective: Body dysmorphic disorder, narcissistic personality disorder, and histrionic personality disorders are the most frequent personality disorders in patients seeking cosmetic interventions. Botulinum toxin type A (BoNTA) injection for cosmetic purpose is the most popular among non-surgical cosmetic procedures and is also the second common aesthetic treatment in Iran. The current study aimed to assess personality disorders in people who were referred for BoNTA injection in Ardabil, Iran...
October 2018: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/30514402/preclinical-pharmacokinetic-evaluation-to-facilitate-repurposing-of-tyrosine-kinase-inhibitors-nilotinib-and-imatinib-as-antiviral-agents
#19
Hari Krishna Ananthula, Scott Parker, Erin Touchette, R Mark Buller, Gopi Patel, Daniel Kalman, Johanna S Salzer, Nadia Gallardo-Romero, Victoria Olson, Inger K Damon, Tessa Moir-Savitz, Larry Sallans, Milton H Werner, Catherine M Sherwin, Pankaj B Desai
BACKGROUND: Several tyrosine kinase inhibitors (TKIs) developed as anti-cancer drugs, also have anti-viral activity due to their ability to disrupt productive replication and dissemination in infected cells. Consequently, such drugs are attractive candidates for "repurposing" as anti-viral agents. However, clinical evaluation of therapeutics against infectious agents associated with high mortality, but low or infrequent incidence, is often unfeasible. The United States Food and Drug Administration formulated the "Animal Rule" to facilitate use of validated animal models for conducting anti-viral efficacy studies...
December 4, 2018: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/30511371/comparison-of-microbial-growth-between-commercial-formula-and-blenderized-food-for-tube-feeding
#20
Teresa W Johnson, D L Milton, Kelly Johnson, Holly Carter, Ryan T Hurt, Manpreet S Mundi, Lisa Epp, Amy L Spurlock
BACKGROUND: Many healthcare facilities and providers prohibit blenderized tube feeding (BTF) for patients who request it due to concerns of high microbial load. The current project compared microbial loads of a standard ready-to-feed polymeric commercial formula (CF), a BTF made using baby food (BTF-BF), and a BTF prepared from blending whole food (BTF-WF), following food safety standards expected of U.S. hospitals. METHODS: Three tube-feeding formulas (CF, BTF-BF, BTF-WF) were prepared in a U...
December 3, 2018: Nutrition in Clinical Practice
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