keyword
https://read.qxmd.com/read/38545781/evolocumab-treatment-in-pediatric-patients-with-homozygous-familial-hypercholesterolemia-pooled-data-from-three-open-label-studies
#21
JOURNAL ARTICLE
Frederick J Raal, Robert A Hegele, Andrea Ruzza, J Antonio G López, Ajay K Bhatia, Johnny Wu, Huei Wang, Daniel Gaudet, Albert Wiegman, Jian Wang, Raul D Santos
BACKGROUND: Pediatric patients with homozygous familial hypercholesterolemia (HoFH) have an increased risk of atherosclerotic cardiovascular disease and difficulty meeting low-density lipoprotein cholesterol (LDL-C) goals. In this post hoc analysis, we evaluated pooled safety and efficacy data from 3 studies in pediatric patients with HoFH treated with the PCSK9 (proprotein convertase subtilisin/kexin type 9) monoclonal antibody inhibitor evolocumab. METHODS: Patients with HoFH aged 10 to 17 years received treatment with open-label evolocumab 420 mg subcutaneously monthly or biweekly in the TAUSSIG, RAMAN, or HAUSER-OLE clinical studies...
March 28, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38545557/combined-allergic-bronchopulmonary-mycosis-and-eosinophilic-granulomatosis-with-polyangiitis-a-case-report-and-literature-review
#22
Ning Cui, Jingluan Wang, Yanmei Shao, Jingming Zhao, Zhaozhong Cheng
A 27-year-old female visited our hospital with a history of asthma, peripheral blood eosinophilia, increased total IgE, Aspergillus fumigatus specific IgE, reversible mild bronchiectasis, sinusitis, bronchial mucus plugs and cultivation of Aspergillus from BALF. Glucocorticoids therapy is effective. These results met the diagnostic criteria for both allergic bronchopulmonary aspergillosis (ABPM) and eosinophilic granulomatosis with polyangiitis (EGPA). Special attention should be paid to the possibility of both diseases coexisting in the disease process...
2024: Respiratory Medicine Case Reports
https://read.qxmd.com/read/38545378/rhein-against-staphylococcus-xylosus-by-interfering-with-respiratory-metabolism-and-inducing-oxidative-stress
#23
JOURNAL ARTICLE
Yuyang Li, Weiwei Chen, Jinxin Ma, Guoying Huang, Guangquan Li, Qiumei He, Xiangyu Kong, Ling Tang, Jinqing Chen, Wenyou Ding, Zhongbin Zhang, Wenya Ding
Currently, dairy mastitis caused by Staphylococcus xylosus poses a serious challenge for dairy farming. In this study, we explored the role and mechanism of rhein against S. xylosus with the hope of providing new research ideas to solve mastitis in dairy cows and ensure the source safety of dairy products. Through in vitro antimicrobial studies, we found that the minimum inhibitory concentration (MIC) of rhein was 64 μg/mL, and it significantly interfered with the formation of S. xylosus biofilm at sub-MIC...
2024: Current research in food science
https://read.qxmd.com/read/38545172/a-novel-signature-integrated-endoplasmic-reticulum-stress-and-apoptosis-related-genes-to-predict-prognosis-for-breast-cancer
#24
JOURNAL ARTICLE
Hao Fan, Mingjie Dong, Chaomin Ren, Pengfei Shao, Yu Gao, Yushan Wang, Yi Feng
BACKGROUND: Breast cancer (BC) is the primary cause of cancer mortality. Herein, we aimed to establish and verify a prognostic model consisting of endoplasmic reticulum stress and apoptosis related genes (ERAGs) to predict patient survival. METHODS: The Cancer Genome Atlas (TCGA) database was used to download gene expression and clinical data to identify the differentially expressed genes (DEGs). Using univariate Cox regression analysis and the Least Absolute Shrinkage and Selection Operator (LASSO)-penalized Cox proportional hazards regression analysis, the prognostic ERAGs were screened...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38545053/deep-learning-based-target-tracking-with-x-ray-images-for-radiotherapy-a-narrative-review
#25
REVIEW
Xi Liu, Li-Sheng Geng, David Huang, Jing Cai, Ruijie Yang
BACKGROUND AND OBJECTIVE: As one of the main treatment modalities, radiotherapy (RT) (also known as radiation therapy) plays an increasingly important role in the treatment of cancer. RT could benefit greatly from the accurate localization of the gross tumor volume and circumambient organs at risk (OARs). Modern linear accelerators (LINACs) are typically equipped with either gantry-mounted or room-mounted X-ray imaging systems, which provide possibilities for marker-less tracking with two-dimensional (2D) kV X-ray images...
March 15, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38545009/clinical-severity-and-high-resolution-ct-severity-score-in-covid-19-is-there-an-association
#26
JOURNAL ARTICLE
Raja Mobeen Ahmed, Kaleem Ullah Toori, Muhammad Arsalan Qureshi
OBJECTIVES: To identify a correlation between the clinical parameters and CT chest severity score in COVID-19. METHODS: A total of 205 RT-PCR positive patients were included in this descriptive cross-sectional study with convenience sampling from November 2020 to June 2021 in KRL Hospital. The study population was stratified in disease severity as per the WHO's guidelines. Clinical and radiological characteristics were compared in survivors and non survivors to draw conclusion...
2024: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/38544976/exploring-biosurfactant-from-halobacterium-jilantaiense-as-drug-against-hiv-and-zika-virus-fabrication-characterization-cytosafety-property-molecular-docking-and-molecular-dynamics-simulation
#27
JOURNAL ARTICLE
Mohammed S Almuhayawi, Naglaa Elshafey, Nashwa Hagagy, Samy Selim, Soad K Al Jaouni, Ahmed R Sofy, Mennatalla Samy, Hattan S Gattan, Mohammed H Alruhaili, Mohanned Talal Alharbi, Mohammed K Nagshabandi, Muyassar K Tarabulsi, Mohamed E Elnosary
Biosurfactants are surface-active molecules with unique qualities and various uses. Many microorganisms produce secondary metabolites with surface-active characteristics that serve various antiviral functions. The HIV and Zika viruses were chosen for this study because they can spread from mother to child and result in potentially fatal infections in infants. Halophilic bacteria from the Red Sea solar saltern in Egypt were screened using drop collapse, emulsification activity, and oil displacement assays to produce biosurfactants and emulsifiers...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38544965/clinical-and-genetic-analysis-of-patients-with-tk2-deficiency
#28
JOURNAL ARTICLE
Francisco Ceballos, Pablo Serrano-Lorenzo, Laura Bermejo-Guerrero, Alberto Blázquez, Juan F Quesada-Espinosa, Jorge Amigo, Pablo Minguez, Carmen Ayuso, Elena García-Arumí, Nuria Muelas, Teresa Jaijo, Andres Nascimento, Beatriz Galán-Rodriguez, Carmen Paradas, Joaquín Arenas, Angel Carracedo, Ramon Martí, Miguel A Martín, Cristina Domínguez-González
OBJECTIVES: Thymidine kinase 2 deficiency (TK2d) is a rare autosomal recessive disorder that stems from a perturbation of the mitochondrial DNA maintenance. Nucleoside treatment has recently shown promise as a disease-modifying therapy. TK2d was initially associated with rapidly progressive fatal myopathy in children featuring mitochondrial DNA depletion. Subsequently, less severe variants of the disease were described, with onset of symptoms during adolescence or adulthood and associated with the presence of multiple mtDNA deletions...
April 2024: Neurology. Genetics
https://read.qxmd.com/read/38544929/silencing-klf6-alleviates-cigarette-smoke-extract-induced-mitochondrial-dysfunction-in-bronchial-epithelial-cells-by-sirt4-upregulation
#29
JOURNAL ARTICLE
Menghong Wan, Chen Wang, Jiamin Cui, Qing Xia, Lei Zhang
BACKGROUND: The incidence of chronic obstructive pulmonary disease (COPD) is increasing year by year. Kruppel-like factor 6 (KLF6) plays an important role in inflammatory diseases. However, the regulatory role of KLF6 in COPD has not been reported so far. METHODS: The viability of human bronchial epithelial cells BEAS-2B induced by cigarette smoke extract (CSE) was detected by CCK-8 assay. The protein expression of KLF6 and sirtuin 4 (SIRT4) was appraised with Western blot...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38544836/radical-prostatectomy-versus-radiotherapy-as-local-therapy-for-primary-tumors-in-patients-with-oligometastatic-prostate-cancer
#30
JOURNAL ARTICLE
Won Sik Ham, Jee Soo Park, Won Sik Jang, Jongchan Kim
INTRODUCTION: We compared radical prostatectomy (RP) and radiotherapy (RT) as local therapies for primary tumors and examined their associations with survival outcomes and urinary tract complications in patients with oligometastatic prostate cancer (omPC). METHODS: We evaluated the data of 85 patients diagnosed with omPC who underwent local therapy for primary tumors between January 2008 and December 2018. Of the 85 patients, 31 underwent prostate RT, while 54 underwent RP...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38544825/molecular-determination-of-tumor-necrosis-factor-alpha-interleukin-8-interleukin-10-and-c-x-c-chemokine-receptor-2-genetic-variations-and-their-association-with-disease-susceptibility-and-mortality-in-covid-19-patients
#31
JOURNAL ARTICLE
Badr A Alsayed, Rashid Mir, Mohammad M Mir, Tarig M S Alnour, Shereen Fawzy, Mesaik M Ahmed, Dnyanesh Amle
BACKGROUND: Altered cytokine levels have been associated with poor outcomes among COVID-19 patients. TNF-α, IL-8 and IL-10 are key cytokines in COVID-19 pathogenesis, and CXCR-2 is a major chemokine receptor involved in inflammatory response. Polymorphisms in the genes of these proteins are proposed to influence disease outcomes. In this study, we aimed to find out the association of genetic polymorphisms in TNF-α, IL-8, IL-10 and CXCR-2 genes with susceptibility to and mortality of COVID-19...
February 23, 2024: Current Genomics
https://read.qxmd.com/read/38544803/long-read-sequencing-reveals-chromothripsis-in-a-molecularly-unsolved-case-of-cornelia-de-lange-syndrome
#32
JOURNAL ARTICLE
Ilaria Bestetti, Milena Crippa, Alessandra Sironi, Matteo Bellini, Francesca Tumiatti, Sara Ballabio, Ferruccio Ceriotti, Luigi Memo, Maria Iascone, Lidia Larizza, Palma Finelli
Thanks to a long-read sequencing (LRS) approach, in this study, we have reported a molecularly solved case of a proband with a clinical diagnosis of Cornelia de Lange syndrome (CDLS), which is a multisystemic disorder whose causative molecular defects involve cohesin complex genes, with NIPBL located at 5p13.2 accounting for approximately 50%-60% of CDLS cases. The first-tier tests revealed an abnormal karyotype 46,XY,t(5;15)(p13;q25)dn and a preserved NIPBL sequencing. Copy number variants (CNVs) at the translocation breakpoints, in disease genes, or in probably pathogenic loci were excluded by a-CGH analysis...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38544617/sars-cov-2-contamination-on-healthy-individuals-hands-in-community-settings-during-the-covid-19-pandemic
#33
JOURNAL ARTICLE
Hidehito Matsui, Miho Sugamata, Harumi Endo, Yumiko Suzuki, Yukiko Takarabe, Yukie Yamaguchi, Rei Hokari, Aki Ishiyama, Chihiro Ueda, Eri Nakajima, Osamu Takeuchi, Atsushi Ujihara, Yasuo Imoto, Hideaki Hanaki
Introduction Hand hygiene is an infection control measure for COVID-19 in our daily lives; however, the contamination levels of SARS-CoV-2 in the hands of healthy individuals remain unclear. Thus, we aimed to evaluate SARS-CoV-2 contamination levels by detecting viral RNA and viable viruses in samples obtained from the hands of 925 healthy individuals. Methods Swab samples were collected from the palms and fingers of healthy participants, including office workers, public officers, university students, university faculty and staff, and hospital staff between December 2022 and March 2023...
February 2024: Curēus
https://read.qxmd.com/read/38544395/casc19-an-oncogenic-long-non-coding-rna-in-different-cancers
#34
JOURNAL ARTICLE
Yinxin Wu, Jie Mou, Gang Zhou, Chengfu Yuan
A 324 bp lncRNA called CASC19 is found on chromosome 8q24.21. Recent research works have revealed that CASC19 is involved in the prognosis of tumors and related to the regulation of the radiation tolerance mechanisms during tumor radiotherapy (RT). This review sheds light on the changes and roles that CASC19 plays in many tumors and diseases, such as nasopharyngeal carcinoma (NPC), cervical cancer, colorectal cancer (CRC), non-small cell lung cancer (NSCLC), clear cell renal cell carcinoma (ccRCC), gastric cancer (GC), pancreatic cancer (PC), hepatocellular carcinoma (HCC), glioma, and osteoarthritis (OA)...
March 27, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38544331/the-impact-of-indole-and-mucin-on-sporulation-biofilm-formation-and-enterotoxin-production-in-foodborne-clostridium-perfringens
#35
JOURNAL ARTICLE
Chao Wang, Tom Defoirdt, Andreja Rajkovic
AIMS: Indole and mucin are compounds found in the host environment as they are produced by the host or by the host-associated microbiota. This study investigated whether indole and mucin impact C. perfringens growth and sporulation, as well as enterotoxin production and biofilm formation. METHODS AND RESULTS: There was no impact on growth of C. perfringens for up to 400 µM indole and 240 mg/L mucin, and neither indole nor mucin affected sporulation. Reverse-transcriptase qPCR showed that mucin strongly upregulated the expression of C...
March 27, 2024: Journal of Applied Microbiology
https://read.qxmd.com/read/38544183/ultralow-noise-chopper-amplifier-for-seafloor-e-field-measurement
#36
JOURNAL ARTICLE
Sixuan Song, Kai Chen
The seafloor E-field signal is extremely weak and difficult to measured, even with a high signal-to-noise ratio. The preamplifier for electrodes is a key technology for ocean-bottom electromagnetic receivers. In this study, a chopper amplifier was proposed and developed to measure the seafloor E-field signal in the nanovolt to millivolt range at significantly low frequencies. It included a modulator, transformer, AC amplifier, high-impedance (hi-Z) module, demodulator, low-pass filter, and chopper clock generator...
March 17, 2024: Sensors
https://read.qxmd.com/read/38543959/development-of-a-potency-assay-for-nous-209-a-multivalent-neoantigens-based-genetic-cancer-vaccine
#37
JOURNAL ARTICLE
Rosa Bartolomeo, Fulvia Troise, Simona Allocca, Giulia Sdruscia, Rosa Vitale, Veronica Bignone, Anna Maria Petrone, Giuseppina Romano, Anna Morena D'Alise, Valentino Ruzza, Irene Garzia, Guido Leoni, Rossella Merone, Francesca Lanzaro, Stefano Colloca, Loredana Siani, Elisa Scarselli, Gabriella Cotugno
Quality control testing of vaccines, including potency assessment, is critical to ensure equivalence of clinical lots. We developed a potency assay to support the clinical advancement of Nous-209, a cancer vaccine based on heterologous prime/boost administration of two multivalent viral vector products: GAd-209 and MVA-209. These consist of a mix of four Adeno (Great Ape Adenovirus; GAd) and four Modified Vaccinia Ankara (MVA) vectors respectively, each containing a different transgene encoding a synthetic polypeptide composed of antigenic peptide fragments joined one after the other...
March 19, 2024: Vaccines
https://read.qxmd.com/read/38543898/antibody-response-after-3-dose-booster-against-sars-cov-2-mrna-vaccine-in-kidney-transplant-recipients
#38
JOURNAL ARTICLE
Domenico Tripodi, Roberto Dominici, Davide Sacco, Gennaro Santorelli, Rodolfo Rivera, Sandro Acquaviva, Marino Marchisio, Paolo Brambilla, Graziana Battini, Valerio Leoni
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with a high rate of mortality in kidney transplant recipients (KTRs). Current vaccine strategies for KTRs seem to be unable to provide effective protection against coronavirus disease 2019 (COVID-19), and the occurrence of severe disease in some vaccinated KTRs suggested a lack of immunity. We initially analyzed the antibody response in a group of 32 kidney transplant recipients (KTRs) followed at the nephrology and dialysis unit of the Hospital Pio XI of Desio, ASST-Brianza, Italy...
March 1, 2024: Vaccines
https://read.qxmd.com/read/38543889/analysis-of-the-presence-and-levels-of-igg-antibodies-directed-against-the-s1-protein-receptor-binding-domain-and-the-n-protein-of-sars-cov-2-in-patients-with-multiple-sclerosis-treated-with-immunomodulatory-therapies
#39
JOURNAL ARTICLE
Joanna Kulikowska, Katarzyna Kapica-Topczewska, Monika Gudowska-Sawczuk, Agnieszka Kulczyńska-Przybik, Marcin Bazylewicz, Anna Mirończuk, Agata Czarnowska, Waldemar Brola, Barbara Mroczko, Jan Kochanowicz, Alina Kułakowska
The coronavirus 2019 disease (COVID-19) course and serological statuses of patients with relapsing-remitting multiple sclerosis (RRMS), treated with disease-modifying therapies (DMTs) are generally parallel that of the general population. Over the pandemic's course, however, a notable increase in the number of RRMS patients who received vaccination against severe acute respiratory coronavirus 2 (SARS-CoV-2) and those who had COVID-19 (symptomatic and asymptomatic) was reported. This virus and/or vaccination likely influenced DMT-treated RRMS patients' serological statuses regarding the presence of SARS-CoV-2 antibodies and their quantitative expression...
February 29, 2024: Vaccines
https://read.qxmd.com/read/38543845/parvovirus-b19-outbreak-in-israel-retrospective-molecular-analysis-from-2010-to-2023
#40
JOURNAL ARTICLE
Orna Mor, Marina Wax, Shoshana-Shani Arami, Maya Yitzhaki, Or Kriger, Oran Erster, Neta S Zuckerman
This study presents an analysis of the epidemiological trends of parvovirus B19 (B19V) in Israel from 2010 to 2023, with particular emphasis on the outbreak in 2023. The analysis utilized molecular diagnostic data from individual patients obtained at the Central Virology Laboratory. Between 2010 and 2022, 8.5% of PCR-tested samples were positive for B19V, whereas in 2023, this percentage surged to 31% of PCR-tested samples. Throughout the study period, annual cycles consistently peaked in early spring/summer, with the most recent prominent outbreak occurring in 2016...
March 20, 2024: Viruses
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