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Pi Liu, Luhong Zhu, Guohui Zou, Huajing Ke
PURPOSE: This study aimed to elucidate the molecular mechanisms of the anti-pancreatic fibrosis effects of matrine in rats. MATERIALS AND METHODS: Trinitrobenzene sulfonic acid was administrated to rats to establish a pancreatic fibrosis model. Rats were divided into four groups: Control, Sham, Model, and Matrine (n=8). Hematoxylin-eosin staining, Masson staining, and Azan staining were performed to evaluate pancreatic fibrosis. Expression of transforming growth factor-β1 (TGF-β1), α-smooth muscle actin (α-SMA), and collagen I in pancreatic tissues was evaluated by immunohistochemical staining...
January 2019: Yonsei Medical Journal
Kyle Wang, Dominic H Moon, Robert J Amdur, Roi Dagan, Nathan C Sheets, Colette J Shen, Rebecca Green, Samip N Patel, Adam M Zanation, Brian D Thorp, Trevor G Hackman, Mark C Weissler, William M Mendenhall, Bhishamjit S Chera
BACKGROUND: We investigated the quality of life (QOL) impact of post-radiation therapy (RT) superselective/selective neck dissection after de-intensified chemoradiation for human papillomavirus-associated oropharynx cancer. METHODS: A total of 147 patients received 60 Gy and weekly low-dose cisplatin on two phase 2 trials with planned post-RT neck dissection or surveillance positron emission tomography with neck dissection reserved for salvage. UW-QOL Shoulder Score, EORTC H&N-35, and EAT-10 were assessed...
December 15, 2018: Head & Neck
Andrew Spillane, Angela Hong, Gerald Fogarty
Previously important roles for adjuvant radiotherapy (RT) in melanoma patients included improved regional control after resection of high-risk nodal disease, to reduce local recurrence for desmoplastic, and other subtypes of melanoma with neurotropism, reducing in-brain relapse of brain metastases after surgery and other situations on a case-by-case basis. This review evaluates the integration of adjuvant RT into clinical practice at this time of rapidly evolving knowledge and improving outcomes from effective systemic therapy...
December 16, 2018: Journal of Surgical Oncology
Barbara Alicja Jereczek-Fossa, Barbara Bortolato, Marianna Alessandra Gerardi, Samantha Dicuonzo, Virginia Maria Arienti, Stefania Berlinghieri, Stefano Bracelli, Michela Buglione, Mariangela Caputo, Gianpiero Catalano, Luigi Franco Cazzaniga, Luigi De Cicco, Nadia Di Muzio, Francesco Romeo Filippone, Andrei Fodor, Davide Franceschini, Paolo Frata, Stefania Gottardo, Giovanni Battista Ivaldi, Antonio Laudati, Stefano Maria Magrini, Elisa Mantero, Ilaria Meaglia, Sara Morlino, Mauro Palazzi, Fabio Piccoli, Paola Romanelli, Marta Scorsetti, Flavia Serafini, Luciano Scandolaro, Riccardo Valdagni, Roberto Orecchia, Paolo Antognoni
AIMS: To evaluate the use of radiotherapy (RT) for oligometastatic cancer (OMC) among radiation oncologists in Lombardy, Italy. METHODS AND STUDY DESIGN: A survey with 12 items regarding data of 2016 was sent to all 34 Lombardy RT centers. The survey included six general items and six specific items regarding patient/disease/treatment characteristics. RESULTS: Thirteen centers answered the survey (38%). All centers responded to general items and 12 centers submitted patient/disease/treatment data...
December 15, 2018: La Radiologia Medica
Wen Yu, Guangjun Jin, Jiancheng Zhang, Wei Wei
The administration of cannabinoid receptor 2 (CB2R) agonist has been reported to produce a cardioprotective effect against the pathogenesis and progression of myocardial infarction (MI). Here in this study, we investigated the specific mechanism related to inflammatory suppression. JWH-133 was used for the activation of CB2R. MI mice models and cardiomyocytes under oxygen-glucose deprivation (OGD) challenge were used for the in vivo and in vitro studies, respectively. Detection of cardiac infarct size and levels of myocardial enzymes as well as echocardiographic examination were applied to assess MI severity and cardiac function...
December 15, 2018: Inflammation
Cheng Peng, Jun Xu, Xiangying Ding, Yuanyuan Lu, Jiao Zhang, Fang Wang, Jiaming Yu, Hongna Wang, Jinsong Zhang
PURPOSE: To assess the effects of posterior sclera reinforcement (PSR) in refractive outcomes, choroidal thickness (CT), and retinal thickness (RT) during a 3-year follow-up in eyes with pathological myopia. METHODS: Thirty-eight eyes of 26 adults with pathological myopia who underwent PSR (the PSR group) and 30 eyes of 18 adults with matched age and myopia who did not receive PSR treatment (the control group) were followed up with measurements of axial length (AL), spherical equivalent (SE), best corrected visual acuity (BCVA), CT, and RT at baseline, 1 and 3 months, and 1, 2, and 3 years postoperatively...
December 15, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Omid Reza Tamtaji, Mohsen Taghizadeh, Esmat Aghadavod, Alireza Mafi, Ehsan Dadgostar, Reza Daneshvar Kakhaki, Javad Abolhassani, Zatollah Asemi
OBJECTIVE: This study was conducted to evaluate the effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression related to inflammation, insulin and lipid in subjects with Parkinson's disease (PD). PATIENTS AND METHODS: This randomized, double-blind, placebo-controlled clinical trial was performed in 40 subjects with PD. Participants were randomly allocated into two groups to take either 1000 mg/day of omega-3 fatty acids from flaxseed oil plus 400 IU/day of vitamin E supplements or placebo (n = 20 each group) for 12 weeks...
December 8, 2018: Clinical Neurology and Neurosurgery
Megha L Nalawade, Rahul S Patil, Laxman N Bavkar, Sheetalnath B Rooge, Vivek S Haldavnekar, Akalpita U Arvindekar
AIMS: Prediabetes manifests several years earlier, before it progresses to diabetes. It is essential to track the earliest metabolic changes occurring in the prediabetic state and to understand the precise mechanism of how diabetes is initiated. MAIN METHODS: Alpha glucosidase was isolated from rat intestine and assayed using maltose as substrate. In vitro glycation of the enzyme was studied using varying fructose content through measurement of fructosamine, general and specific fluorescence...
December 13, 2018: Life Sciences
Xiao-Wen Zhu, Jing Wang, Ming-Xia Zhu, Yan-Fang Wang, Si-Yuan Yang, Xiao-Yan Ke
BACKGROUND: Aberrant expression of B7 homologue 3 (B7H3) has been observed in various malignancies. Our previous study demonstrated that knocking down of B7H3 inhibited cell proliferation, invasion and enhanced the therapeutic efficacy of chemotherapy in mantle cell lymphoma (MCL). However, the mechanism regulating of B7H3 expression remains unknown. Here, we present a new regulatory microRNA of B7H3, miR-506, that directly targets B7H3 and may play an inhibitory role in MCL progression...
December 12, 2018: Biochemical and Biophysical Research Communications
Fenbo Ma, Xiangchao Pang, Bin Tang
Chondrocytes culture within three-dimensional (3D) hydrogels is an attractive strategy for expanding their potential in various biomedical applications. Molecular weight (MW) of the polymers used for preparing one-component hydrogels for 3D cell culture can affect the activity of chondrocytes. However, whether MW of double network hydrogels affects cell fate remains to be determined. Here, a ternary hydrogel was employed to encapsulate chondrocytes. By altering MW of alginate, the hybrid hydrogels with different mechanical properties were prepared...
February 15, 2019: Carbohydrate Polymers
Tulio M Fumian, Julia M Fioretti, Jennifer H Lun, Ingrid A L Dos Santos, Peter A White, Marize P Miagostovich
Noroviruses are a leading cause of epidemic and pandemic acute gastroenteritis (AGE) worldwide, and contaminated food and water are important routes for its transmission. Raw sewage has been used for viral surveillance to monitor the emergence of new norovirus strains with the potential to cause epidemics. In this study, we investigated norovirus occurrence and norovirus RNA levels in 156 samples collected from May 2013 to May 2014, across three different stages (52 samples each) of a wastewater treatment plant (WWTP) in Rio de Janeiro, Brazil...
December 12, 2018: Environment International
Lynda Bourebaba, Izabela Michalak, Michael Röcken, Krzysztof Marycz
Reactive oxygen species (ROS) are key mediators of several cellular damage and thus associated with equine diseases such as inflammation and metabolic syndrome. This study aimed to evaluate the protective and antioxidant activities of methanolic extract prepared from Cladophora glomerata (C. glomerata) biomass, on equine adipose derived mesenchymal stem cells (EqASCs), under experimental oxidative stress induced by H2 O2 . Pre-treatment of EqASCs cells with different concentrations of C. glomerata methanolic extract (1% and 5%) provided a clear protection against cellular damage triggered by H2 O2 ...
December 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Rebecca Peters, Mario Stevenson
BACKGROUND: Since its sudden appearance and link to microcephaly in 2015, the number of PubMed references for Zika virus (ZIKV) has risen from 181 to 5,163, as of writing, with a vast proportion focused on the consequences of ZIKV infection during pregnancy. This level of attention underlies increased demand for sensitive and specific diagnostic tools able to assess risk to an unborn child, as well as to understand the dynamics and consequences of viral persistence. AIM: Review the expanding knowledge on ZIKV persistence and diagnostic challenges and summarize current advancements in detection...
December 12, 2018: Clinical Microbiology and Infection
Ruizhen Li, Nan Wang, Min Xue, Wenxin Long, Chunxia Cheng, Chunmei Mi, Zhou Gao
Preeclampsia (PE), a pregnancy-specific disorder, is a leading cause of perinatal maternal and fetal mortality and morbidity. Impaired migration and invasion of trophoblastic cells and an imbalanced systemic maternal inflammatory response have been proposed as possible causes of pathogenesis of PE. Comparative analysis of PE-affected placentas and healthy placentas has uncovered differentially expressed long noncoding RNAs, microRNAs, and mRNAs. This study was conducted to investigate the effect of a regulatory network among these RNAs on PE pathogenesis...
December 12, 2018: Cellular Signalling
Andrew J Bishop, Maria A Zarzour, Ravin Ratan, Keila E Torres, Barry W Feig, Wei-Lien Wang, Alexander J Lazar, Bryan S Moon, Christina L Roland, B Ashleigh Guadagnolo
OBJECTIVE: To update our experience with long-term outcomes in patients with desmoid fibromatosis treated with radiation therapy (RT) and to characterize factors associated with increased risk of local recurrence. METHODS: We reviewed the records of 209 consecutive patients with desmoid fibromatosis treated with RT, either alone or as combined modality therapy (CMT) with surgery, at our institution from 1965 to 2015. RESULTS: Median follow-up time was 98 months (range, 1-509 months)...
December 12, 2018: International Journal of Radiation Oncology, Biology, Physics
Natan Feter, Roselia Maria Spanevello, Mayara Sandrielly Pereira Soares, Luiza Spohr, Nathalia Stark Pedra, Natália Pontes Bona, Matheus Pintanel Freitas, Nicole Gomes Gonzales, Luiz Guilherme Martinho Sampaio Ito, Francieli Moro Stefanello, Airton José Rombaldi
The present study investigated the chronic effects of different physical exercise and physical activity models on cognitive function, cholinergic activity, and oxidative stress markers in the cerebral cortex and hippocampus. Eighty 60-day old C57BL/6 mice were divided into the following five groups: Sedentary (SED), moderate-intensity continuous training (MICT), high-intensity interval training (HIIT), resistance training (RT), and physical activity (RW, for "running wheel"). Cognitive function (recognition and spatial memory), oxidative stress parameters, and acetylcholinesterase (AChE) activity in the cerebral cortex and hippocampus were evaluated...
December 12, 2018: Physiology & Behavior
Michell Charlles de Souza Costa, Laura Marina Siqueira Maia, Victor Costa de Souza, Andréia Maria Gonzaga, Vergínia Correa de Azevedo, Letícia Ramos Martins, Juliana Helena Chaves Pavoni, Felipe Gomes Naveca, Renata Dezengrini Slhessarenko
Arboviruses have become a major public health concern in Brazil, especially after Zika virus (ZIKV) and Chikungunya virus (CHIKV) introduction, leading to massive epidemics. We conducted an investigation of arboviruses in patients with acute febrile illness for less than five days in Mato Grosso state (MT) during the period of ZIKV and CHIKV dissemination in Brazil. To achieve that, 453 human serum samples of patients suspected of Dengue (DENV), Yellow Fever (YFV), ZIKV or CHIKV collected in health units of 31 cities of MT were subjected to RT-PCR protocols for 10 flaviviruses, 5 alphaviruses and orthobunyaviruses from Simbu serogroup, nucleotide sequencing and viral isolation...
December 12, 2018: Acta Tropica
Pedro A R Fernandes, Sílvia A Moreira, Mauro D Santos, Ricardo V Duarte, Diana I Santos, Rita S Inácio, Susana P Alves, Rui J B Bessa, Ivonne Delgadillo, Jorge A Saraiva
Hyperbaric storage (HS) at variable room temperature (RT) has been proposed as an alternative to refrigeration at atmospheric pressure (RF/AP) for food preservation and scarce information is available regarding HS effect in meat products. In this study the RT/HS effect was evaluated at 100 MPa and variable RT (≈20 °C) for minced meat preservation up to 24 h, initially for one batch, and further two other different batches were independently studied. To assess RT/HS feasibility, microbiological and physicochemical parameters were analyzed, using storage at RF/AP and variable RT/AP (≈20 °C), for comparison...
December 15, 2018: Journal of the Science of Food and Agriculture
Hossein Zakariapour Bahnamiri, Mahdi Ganjkhanlou, Abolfazl Zali, Mostafa Sadeghi, Hossein Moradi Shahrbabak, Gholam Ali Nehzati Paghaleh
Fat-tailed sheep breeds can tolerate periods of negative energy balance without suffering from elevated concentration of plasma non-esterified fatty acid (NEFA). This ability was attributed to unique metabolism of fat-tailed adipose depot, whereas role of liver as an influential organ in fatty acid metabolism was not evaluated yet. Hence, current study was conducted to evaluate the effects of negative and positive energy balances on liver expression of genes related to fatty acid metabolism in fat-tailed and thin-tailed lambs...
December 14, 2018: Journal of Animal Physiology and Animal Nutrition
Qun Luo, Wanglong Deng, Haiwei Wang, Huiyong Fan, Ji Zhang
Bromodomain-containing 4 (BRD4) has been considered as an important requirement for disease maintenance and an attractive therapeutic target for cancer therapy. This protein can be targeted by JQ1, a selective small-molecule inhibitor. However, few studies have investigated whether BRD4 influenced acute promyelocytic leukemia (APL), and whether BRD4 had interaction with promyelocytic leukemia-retinoic acid receptor α (PML/RARα) fusion protein to some extent. Results from cell viability assay, cell cycle analysis, and Annexin-V/PI analysis indicated that JQ1 inhibited the growth of NB4 cells, an APL-derived cell line, and induced NB4 cell cycle arrest at G1 and apoptosis...
December 2018: Frontiers of Medicine
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