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New generation of spinal cages

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https://www.readbyqxmd.com/read/23469317/diagnosis-of-depression-in-adolescents-following-traumatic-fracture-a-retrospective-analysis
#1
Alyson L Kepple, James N Irvine, Vishal Madaan
OBJECTIVE: To assess how frequently adolescents are clinically diagnosed with depression following hospitalization for traumatic fracture, with the assumption that a retrospective approach would yield lower rates of depression compared to those reported previously in prospective studies. We hypothesized that depression would be less common among adolescents whose injuries were primarily limited to fractures of the appendicular skeleton, vertebral column, and/or thoracic cage compared to those sustaining concomitant spinal cord and/or brain injuries and those suffering from facial/skull fractures...
2012: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/22617171/bone-grafting-and-substitutes-in-spine-surgery
#2
REVIEW
M Cabraja, S Kroppenstedt
The increase of spinal procedures over the last decades has made the long-term problems, such as pseudarthrosis, apparent. This demands optimized strategies, techniques and technologies. Modern fixation systems have been developed as an adjunct to spinal fusion, and several generations of different synthetic cages have proved to be reasonable alternatives to autologous bone or allografts. The development of recombinant bone morphogenetic proteins (BMPs) is of promise, because of their great osteoinductive capabilities...
June 2012: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/20521963/cervical-motion-preservation-using-mesenchymal-progenitor-cells-and-pentosan-polysulfate-a-novel-chondrogenic-agent-preliminary-study-in-an-ovine-model
#3
Tony Goldschlager, Peter Ghosh, Andrew Zannettino, Stan Gronthos, Jeffrey V Rosenfeld, Silviu Itescu, Graham Jenkin
OBJECT: There is an unmet need for a procedure that could generate a biological disc substitute while at the same time preserving the normal surgical practice of achieving anterior cervical decompression. The objective of the present study was to test the hypothesis that adult allogeneic mesenchymal progenitor cells (MPCs) formulated with a chondrogenic agent could synthesize a cartilaginous matrix when implanted into a biodegradable carrier and cage, and over time, might serve as a dynamic interbody spacer following anterior cervical discectomy (ACD)...
June 2010: Neurosurgical Focus
https://www.readbyqxmd.com/read/19441986/ceramic-granules-enhanced-with-b2a-peptide-for-lumbar-interbody-spine-fusion-an-experimental-study-using-an-instrumented-model-in-sheep
#4
Bryan W Cunningham, Brent L Atkinson, Nianbin Hu, Jun Kikkawa, Louis Jenis, Joseph Bryant, Paul O Zamora, Paul C McAfee
OBJECT: New generations of devices for spinal interbody fusion are expected to arise from the combined use of bioactive peptides and porous implants. The purpose of this dose-ranging study was to evaluate the fusion characteristics of porous ceramic granules (CGs) coated with the bioactive peptide B2A2-K-NS (B2A) by using a model of instrumented lumbar interbody spinal fusion in sheep. METHODS: Instrumented spinal arthrodesis was performed in 40 operative sites in 20 adult sheep...
April 2009: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/19190924/a-new-distractable-implant-for-vertebral-body-replacement-biomechanical-testing-of-four-implants-for-the-thoracolumbar-spine
#5
COMPARATIVE STUDY
M Reinhold, W Schmoelz, F Canto, D Krappinger, M Blauth, Christian Knop
INTRODUCTION: Expandable titanium implants for vertebral body replacement in the thoracolumbar spine have been well established in the reconstruction of the anterior spinal column. Load transfer at the bone-implant interface remains a point of concern. The purpose of the study was to compare the performance in axial load transfer from the implant to the vertebral body in four different implants, all of them in clinical use to date. MATERIALS AND METHODS: We tested a second generation implant (Synex II) in comparison to three different expandable titanium cages: Synex I, Obelisc and X-Tenz...
October 2009: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/16518854/single-muscle-fiber-size-and-contractility-after-spinal-cord-injury-in-rats
#6
COMPARATIVE STUDY
Walter R Frontera, Howard Choi, Gomathi Krishnan, Lisa S Krivickas, Sunil Sabharwal, Yang D Teng
Spinal cord injury (SCI) results in muscle weakness but the degree of impairment at the level of single fibers is not known. The purpose of this study was to examine the effects of T9-level SCI on single muscle fibers from the tibialis anterior of rats. Significant decreases in cross-sectional area (CSA), maximal force (Po), and specific force (SF = Po/CSA) were noted at 2 weeks. Atrophy and force-generating capacity were reversed at 4 weeks, but SF remained impaired. Maximum shortening velocity (Vo) did not change after injury...
July 2006: Muscle & Nerve
https://www.readbyqxmd.com/read/16292588/bioresorbable-polymers-heading-for-a-new-generation-of-spinal-cages
#7
REVIEW
P I J M Wuisman, T H Smit
The use of polymer-based bioresorbable materials is now expanding to the realm of spinal interbody fusion. Bioresorbable polymers have important advantages over metals, because they are temporary, much less stiff, and radiolucent. Most promising is a group of alpha-polyesters, in particular polylactide acids (PLAs). Their biocompatibility is excellent, and they have sufficient stiffness and strength to provide initial and intermediate-term stability required for bone healing. However, polylactides have characteristics that make them vulnerable to complications if not properly controlled...
February 2006: European Spine Journal
https://www.readbyqxmd.com/read/15457695/prediction-of-spinal-deformity-in-scoliosis-from-geometric-torsion
#8
Philippe Poncet, Jacob L Jaremko, Janet Ronsky, James Harder, Jean Dansereau, Hubert Labelle, Ronald F Zernicke
The shape of a curved line that passes through thoracic and lumbar vertebrae is often used to study spinal deformity with measurements in "auxiliary" planes that are not truly three-dimensional (3D). Here we propose a new index, the geometric torsion, which could uniquely describe the spinal deformity. In this study we assessed whether geometric torsion could be effectively used. to predict spinal deformity with the aid of multiple linear regression. Anatomical landmarks were obtained from multi-view radiographic reconstruction and used to generate 3D model of the spine and rib cage of 28 patients...
2002: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/15303018/interbody-fusion-cage-design-using-integrated-global-layout-and-local-microstructure-topology-optimization
#9
Chia-Ying Lin, Chun-Ching Hsiao, Po-Quan Chen, Scott J Hollister
STUDY DESIGN: An approach combining global layout and local microstructure topology optimization was used to create a new interbody fusion cage design that concurrently enhanced stability, biofactor delivery, and mechanical tissue stimulation for improved arthrodesis. OBJECTIVE: To develop a new interbody fusion cage design by topology optimization with porous internal architecture. To compare the performance of this new design to conventional threaded cage designs regarding early stability and long-term stress shielding effects on ingrown bone...
August 15, 2004: Spine
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