keyword
https://read.qxmd.com/read/38199514/impact-of-center-volume-on-outcomes-after-ventricular-assist-device-implantation-in-pediatric-patients-an-analysis-of-the-sts-pedimacs-database
#21
JOURNAL ARTICLE
Shahnawaz Amdani, Bradley S Marino, Gerard Boyle, Amy Cassedy, Angela Lorts, David Morales, Anna Joong, Danielle Burstein, Neha Bansal, David L Sutcliffe
BACKGROUND: To date, no pediatric studies have highlighted the impact of center's ventricular assist device (VAD) volumes on post implant outcomes. METHODS: Children (age <19) enrolled in Pedimacs undergoing initial left ventricular assist device implantation from 2012 to 2020 were included. Center volume was analyzed as a continuous and categorical variable. For categorical analysis, center volumes were divided as: low volume (1-15 implants), medium volume (15-30 implants), and high volume (>30 implants) during our study period...
January 9, 2024: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/38165182/characteristics-and-outcomes-of-patients-in-the-emergency-department-with-left-ventricular-assist-devices
#22
MULTICENTER STUDY
Alexander S Finch, Michael M Mohseni, Leslie V Simon, Jennifer G Finch, Lemuel E Gordon-Hackshaw, Aaron B Klassen, Aidan F Mullan, David W Barbara, Benjamin J Sandefur
INTRODUCTION: Left ventricular assist devices (LVAD) are increasingly common among patients with heart failure. The unique physiologic characteristics of patients with LVADs present a challenge to emergency clinicians making treatment and disposition decisions. Despite the increasing prevalence of LVADs, literature describing emergency department (ED) visits among this population is sparse. We aimed to describe clinical characteristics and outcomes among patients with LVADs seen in two quaternary-care EDs in a five-year period...
November 2023: Western Journal of Emergency Medicine
https://read.qxmd.com/read/38161187/device-related-thrombosis-and-bleeding-in-pediatric-health-care-a-meta-analysis
#23
JOURNAL ARTICLE
Amanda Ullman, Areum Hyun, Victoria Gibson, Fiona Newall, Mari Takashima
CONTEXT: The risk of invasive device-related thrombosis and bleeding contributes to morbidity and mortality, yet their prevalence by device-types is poorly understood. OBJECTIVES: This study aimed to estimate pooled proportions and rates of thrombotic and bleeding complications associated with invasive devices in pediatric health care. DATA SOURCES: Medline, CINAHL, Embase, Web of Science, Scopus, Cochrane CENTRAL, clinical trial registries, and unpublished study databases were searched...
January 1, 2024: Hospital Pediatrics
https://read.qxmd.com/read/38131635/inhibition-of-angiogenesis-in-the-management-of-refractory-gastrointestinal-bleeding-in-patients-with-lvad-support
#24
JOURNAL ARTICLE
Sara S Inglis, Rabea Asleh, Vivek N Iyer, Sarah D Schettle, Philip J Spencer, Mauricio A Villavicencio, Richard J Rodeheffer, Sudhir S Kushwaha, Atta Behfar, Andrew N Rosenbaum
BACKGROUND: Gastrointestinal bleeding (GIB) in patients with continuous flow left ventricular assist devices (CF-LVADs) is often related to GI angiodysplasia (GIAD). We previously reported data on VEGF inhibition with IV bevacizumab in the treatment of LVAD-associated GIAD bleeding, and now present follow-up data on patients treated with IV bevacizumab and/or low-dose oral pazopanib. METHODS: All consecutive adult patients with LVAD-associated GIB from GIAD treated with bevacizumab or pazopanib, from July 20, 2017 to June 22, 2022, were included in the analysis...
December 22, 2023: Artificial Organs
https://read.qxmd.com/read/38117639/the-left-ventricular-assist-device-a-literature-review-and-guidelines-for-dental-care
#25
JOURNAL ARTICLE
Young Hwan Kim, Jennifer Pavone, Vivian A B Wasmuht-Perroud, Robert W Frare, Paul R Baker
About 6.2 million adults in the United States suffer from heart failure (HF). For patients with advanced HF refractory to medical therapy, an orthotopic heart transplant or a ventricular assist device (VAD) is the only long-term survival option. The most commonly used form of these devices is the left VAD (LVAD), implanted to support the left ventricle. As many as 2754 LVADs were implanted annually between 2006 and 2015, allowing recipients to maintain a relatively normal lifestyle, including both elective and emergency dental care in the ambulatory setting...
2024: General Dentistry
https://read.qxmd.com/read/38106739/intracerebral-hematoma-in-patients-with-impella-ventricular-assist-device-placement-for-cardiogenic-shock-report-of-three-cases
#26
Mitsuki Horio, Daina Kashiwazaki, Takahiro Tomita, Kunitaka Maruyama, Saori Hamada, Emiko Hori, Makiko Nakamura, Koichiro Kinugawa, Satoshi Kuroda
Despite the clear benefits of Impella in patients with cardiogenic shock, bleeding is a possible complication. Herein, we report three cases of intracerebral hemorrhage in patients with Impella implantation for cardiogenic shock, which were treated with hematoma evacuation. We present the clinical features, diagnosis, and management (hematoma evacuation) of patients with the Impella device (Abiomed, Danvers, Massachusetts) who developed intracerebral hemorrhage. Case one was a 56-year-old man who presented with chest pain and loss of consciousness, was diagnosed with acute myocardial infarction, and underwent urgent percutaneous coronary intervention and Impella placement...
November 2023: Curēus
https://read.qxmd.com/read/38093767/from-medical-therapy-to-mechanical-support-strategies-for-device-selection-and-implantation-techniques
#27
JOURNAL ARTICLE
Letizia F Bertoldi, Andrea Montisci, Dirk Westermann, Mario Iannaccone, Vasileios Panoulas, Nikos Werner, Norman Mangner
Cardiogenic shock (CS) is a complex clinical syndrome with a high risk of mortality. The recent, rapid development of temporary mechanical circulatory support (tMCS) has altered CS treatment. While catecholamines remain the cornerstone of CS therapy, tMCS usage has increased. According to shock severity, different treatment strategies including catecholamines alone, catecholamines and tMCS, or multiple tMCS might be used. State-of-the-art implantation techniques are necessary to avoid complications linked to the invasive nature of tMCS...
December 2023: European Heart Journal Supplements: Journal of the European Society of Cardiology
https://read.qxmd.com/read/38084653/bivalirudin-anticoagulation-for-cardiopulmonary-bypass-during-cardiac-surgery
#28
REVIEW
Noy Meshulami, Raghav Murthy, Maisy Meyer, Andrew D Meyer, Shubhi Kaushik
INTRODUCTION: Heparin is the primary anticoagulant for cardiopulmonary bypass (CPB) support during cardiac surgery. While widely used, ∼2% of cardiac surgery patients develop heparin-induced thrombocytopenia (HIT) and 4-26% develop heparin resistance. Bivalirudin is an alternative anticoagulant mainly used for percutaneous coronary interventions. Given the challenges associated with heparin anticoagulation, we conducted a review to explore the use of bivalirudin for CPB surgery...
December 12, 2023: Perfusion
https://read.qxmd.com/read/38079280/aortic-arch-branching-variations-and-risk-of-cerebrovascular-accidents-in-patients-with-a-left-ventricular-assist-device
#29
JOURNAL ARTICLE
Casper F Zijderhand, Jelena Sjatskig, Denne A Scharink, Jette J Peek, Ozcan Birim, Jos A Bekkers, Ad J J C Bogers, Kadir Caliskan
AIMS: This retrospective study investigated the association between anatomical variations in the aortic arch branching and adverse events, including the risk of cerebrovascular accidents (CVAs), in patients with a left ventricular assist device (LVAD). METHODS: Medical charts were reviewed for all patients with HeartMate 3 LVAD support at our center from 2016 to 2021. Computed tomography scans were evaluated to categorize the variations in the aortic arch branching based on seven different types, as described in the literature...
January 1, 2024: Journal of Cardiovascular Medicine
https://read.qxmd.com/read/38068287/role-of-genetic-polymorphisms-in-the-development-of-complications-in-patients-with-implanted-left-ventricular-assist-devices-heartware-heartmate-ii-and-heartmate-3
#30
JOURNAL ARTICLE
Madina R Zhalbinova, Saule E Rakhimova, Ulan A Kozhamkulov, Gulbanu A Akilzhanova, Assel A Chinybayeva, Kenes R Akilzhanov, Nurlan K Shaimardanov, Anargul G Kuanysheva, Joseph H Lee, Ulykbek Y Kairov, Makhabbat S Bekbossynova, Ainur R Akilzhanova
Left ventricular assist device (LVAD) implantation is one of the mechanical circulatory support (MCS) treatments for advanced heart failure (HF) patients. MCS has emerged as a lifesaving therapy that improves patients' quality of life. However, MCS remains limited by a paradoxical coagulopathy accompanied by thrombosis and bleeding. The mechanisms of MCS thrombosis are increasingly being defined, but MCS-related bleeding, which is related to shear-mediated alteration of platelet function, remains poorly understood...
November 22, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38065237/gastrointestinal-bleeding-following-heartmate-3-left-ventricular-assist-device-implantation-the-michigan-bleeding-risk-model
#31
JOURNAL ARTICLE
Yoav Hammer, Jiaheng Xie, Guangyu Yang, Abbas Bitar, Jonathan W Haft, Thomas M Cascino, Donald S Likosky, Francis D Pagani, Min Zhang, Keith D Aaronson
BACKGROUND: Gastrointestinal bleeding (GIB) results in frequent hospitalizations and impairs quality of life in durable left ventricular assist device (LVAD) recipients. Anticipation of these events before implantation could have important implications for patient selection and management. METHODS: The study population included all adult HeartMate 3 (HM3) primary LVAD recipients enrolled in the STS-Intermacs registry from January 2017-December 2020. Using multivariable modeling methodologies, we investigated the relationships between preimplantation characteristics and postimplant bleeding, bleeding and death, and additional bleeding episodes on subsequent bleeding episodes, and created a risk score to predict the likelihood of post-LVAD GIB based solely on pre-implantation factors...
December 6, 2023: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/38048601/impella-device-in-fulminant-myocarditis-japanese-registry-for-percutaneous-ventricular-assist-device-j-pvad-registry-analysis-on-outcomes-and-adverse-events
#32
JOURNAL ARTICLE
Takahito Nasu, Ryo Ninomiya, Yorihiko Koeda, Yoshihiro Morino
AIMS: Given that fulminant myocarditis, characterized by unstable hemodynamics, is a significant clinical challenge and that traditional pharmacological treatments have limitations, evaluating alternatives such as the Impella device is a crucial focus of this study. Further, this study presents pioneering large-scale registry data on its use in managing fulminant myocarditis. METHODS: Data from the Japanese Registry for Percutaneous Ventricular Assist Devices (J-PVAD) was analyzed to assess Impella's role in managing fulminant myocarditis from February 2020 to December 2021...
December 4, 2023: European Heart Journal. Acute Cardiovascular Care
https://read.qxmd.com/read/38045436/monitoring-left-ventricular-assist-device-parameters-to-detect-flow-and-power-impacting-complications-a-proof-of-concept
#33
JOURNAL ARTICLE
Mehran Moazeni, Lieke Numan, Mariusz K Szymanski, Niels P Van der Kaaij, Folkert W Asselbergs, Linda W van Laake, Emmeke Aarts
AIMS: The number of patients on left ventricular assist device (LVAD) support increases due to the growing number of patients with end-stage heart failure and the limited number of donor hearts. Despite improving survival rates, patients frequently suffer from adverse events such as cardiac arrhythmia and major bleeding. Telemonitoring is a potentially powerful tool to early detect deteriorations and may further improve outcome after LVAD implantation. Hence, we developed a personalized algorithm to remotely monitor HeartMate3 (HM3) pump parameters aiming to early detect unscheduled admissions due to cardiac arrhythmia or major bleeding...
December 2023: European heart journal. Digital health
https://read.qxmd.com/read/38039542/associations-between-preimplant-cancer-type-and-left-ventricular-assist-device-outcomes-an-intermacs-registry-analysis
#34
JOURNAL ARTICLE
Rebecca S Steinberg, Aditi Nayak, Alexis Okoh, Jeffrey Wang, Erin Matiello, Alanna A Morris, Jennifer A Cowger, Anju Nohria
We used the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) database to examine whether history of a solid versus hematologic malignancy impacts outcomes after left ventricular assist device (LVAD) implantation. We included LVAD recipients (2007-2017) with cancer history reported (N = 14,799, 21% female, 24% Black). Multivariate models examined the association between cancer type and post-LVAD mortality and adverse events. Competing risk analyses compared death and heart transplantation between cancer types and those without cancer in bridge-to-transplant (BTT) patients...
November 30, 2023: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/37997292/mechanical-circulatory-support-versus-vasopressors-alone-in-patients-with-acute-myocardial-infarction-and-cardiogenic-shock-undergoing-percutaneous-coronary-intervention
#35
JOURNAL ARTICLE
Awad I Javaid, Joel E Michalek, Aleksandra B Gruslova, Serene A Hoskins, Chowdhury H Ahsan, Marc D Feldman
BACKGROUND: Previous studies have compared Impella use to intra-aortic balloon pump (IABP) use in patients with acute myocardial infarction and cardiogenic shock (AMI-CS) undergoing percutaneous coronary intervention (PCI). Our objective was to compare clinical outcomes in patients with AMI-CS undergoing PCI who received Impella (percutaneous left ventricular assist device) without vasopressors, IABP without vasopressors, and vasopressors without mechanical circulatory support (MCS). METHODS: We queried the National Inpatient Sample (NIS) using ICD-10 codes (2015-2018) to identify patients with AMI-CS undergoing PCI...
November 23, 2023: Catheterization and Cardiovascular Interventions
https://read.qxmd.com/read/37990598/evaluation-of-enoxaparin-for-bridging-of-warfarin-in-outpatients-with-left-ventricular-assist-devices-lvads
#36
JOURNAL ARTICLE
Aklil Hiruy, Keith Anderson, Sanjeeb Bhattacharya, Ran Lee, James B Williams
BACKGROUND: Patients with left ventricular assist devices (LVADs) require systemic anticoagulation. The use of enoxaparin for bridging to warfarin remains understudied in this population. METHODS: This single-center retrospective study was performed to characterize enoxaparin use and associated thrombotic and bleeding outcomes in adult outpatients with LVADs from January 2018 to July 2021. RESULTS: Fifty-four enoxaparin bridging events were evaluated in 49 patients...
November 21, 2023: Artificial Organs
https://read.qxmd.com/read/37990175/secondary-analysis-of-potential-associations-between-oral-health-and-infection-related-parameters-in-patients-with-severe-heart-failure-results-of-a-german-cohort
#37
JOURNAL ARTICLE
Gerhard Schmalz, Alina Hennecke, Rainer Haak, Tanja Kottmann, Jens Garbade, Christian Binner, Dirk Ziebolz
OBJECTIVES: Aim of this retrospective cohort study was to evaluate whether oral health parameters would be associated with infection-related parameters and overall survival of patients with severe heart failure (HF). METHODS: Patients with severe HF, heart transplantation (HTx) and left-ventricular assist device (LVAD), which underwent a full oral examination between 2017 and 2018 were included. Infection-related and survival data were assessed from the patient´s medical records...
November 21, 2023: BMC Cardiovascular Disorders
https://read.qxmd.com/read/37988070/using-noninvasive-clinical-parameters-to-predict-mortality-and-morbidity-after-cardiac-interventions-in-patients-with-cirrhosis-a-systematic-review
#38
JOURNAL ARTICLE
Christo Mathew, Ankur Patel, George Cholankeril, Avegail Flores, Ruben Hernaez
BACKGROUND: Cardiovascular disease commonly affects advanced liver disease patients. They undergo cardiac interventions to improve cardiac outcomes. Cirrhosis increases complication risk, including bleeding, renal and respiratory failure, and further decompensation, including death, posing a clinical dilemma to proceduralists. Predicting outcomes is crucial in managing patients with cirrhosis. Our aim was to systematically review clinical parameters to assess the mortality and complication risk in patients with cirrhosis undergoing cardiac interventions...
January 1, 2024: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/37980622/treating-heparin-induced-thrombocytopenia-in-patients-undergoing-heartmate-3-left-ventricular-assist-device-implantation
#39
JOURNAL ARTICLE
Jonathan Eisenberger, Shmuel Somer, Eilon Ram, Eyal Nachum, Jonathan Frogal, Shany Levin, Jacob Lavee, Leonid Sternik, Jeffrey Morgan
BACKGROUND: Unfractionated heparin is the preferred anticoagulant used during open heart surgeries, including left ventricular assist device (LVAD) implantation. In cases in which patients are heparin-induced thrombocytopenia positive (HIT+), the accepted practice has been to substitute heparin with bivalirudin. This practice may be associated with significant bleeding and adverse outcomes. OBJECTIVES: To review our experience with HIT+ patients who were heparin-induced thrombocytopenia with thrombosis negative (HITT-) and who underwent HeartMate 3 LVAD implantation using heparin intraoperatively rather than bivalirudin...
November 2023: Israel Medical Association Journal: IMAJ
https://read.qxmd.com/read/37972458/an-in-silico-analysis-of-unsteady-flow-structures-in-a-microaxial-blood-pump-under-a-pulsating-rotation-speed
#40
JOURNAL ARTICLE
Chenghan Chen, Mingkui Zhang, Pengfei Hao, Feng He, Xiwen Zhang
BACKGROUND AND OBJECTIVE: Ventricular assist devices (VADs) are generally designed to perform continuous flow. However, it has been proven that continuous flow, which is not a physiological hemodynamic state, may cause severe complications such as gastrointestinal bleeding, pulmonary hypertension, and ventricular suction. For these reasons, many pulsating blood pump control strategies have been proposed and have the potential for application in percutaneous ventricular assist devices (pVADs) or microaxial blood pumps...
November 7, 2023: Computer Methods and Programs in Biomedicine
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