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ventricular assist device bleeding

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https://www.readbyqxmd.com/read/30073890/video-capsule-endoscopy-is-safe-and-effective-in-suspected-small-bowel-bleeding-among-left-ventricular-assist-device-recipients
#1
David Itskoviz, Ben Ben Avraham, Hagar Banai, Irit Avni, Tuvia Ben Gal, Iris Dotan, Eyal Gal
INTRODUCTION: Suspected small bowel bleeding is frequently encountered in left ventricular assist device recipients and the identification of the culprit lesion may be challenging. Data regarding the safety and yield of small bowel capsule in the investigation of suspected small bowel bleeding are limited. We aimed to evaluate the safety and efficacy of small bowel video capsule endoscopy for the investigation of suspected small bowel bleeding among left ventricular assist device recipients...
August 3, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/30064855/readmission-patterns-during-long-term-follow-up-after-left-ventricular-assist-device-implantation
#2
Himabindu Vidula, Valentina Kutyifa, Brent A Johnson, Robert L Strawderman, Donald Harrington, Bronislava Polonsky, Anna Papernov, Jeffrey D Alexis
As more patients are supported for longer periods by a left ventricular assist device (LVAD), hospital readmission is becoming a growing problem. However, data about temporal changes in readmission rates and causes for patients with prolonged LVAD support are limited. We aimed to evaluate rates, causes, and predictors of any and long-term readmission after LVAD placement at our institution. We followed 177 HeartMate II LVAD patients for a mean of 1.90 ± 1.33 years post initial discharge after implantation...
June 21, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/30052304/long-term-evaluation-of-a-fully-magnetically-levitated-circulatory-support-device-for-advanced-heart-failure-two-year-results-from-the-heartmate-3-ce-mark-study
#3
Jan D Schmitto, Yuriy Pya, Daniel Zimpfer, Thomas Krabatsch, Jens Garbade, Vivek Rao, Michiel Morshuis, Friedhelm Beyersdorf, Silvana Marasco, Poornima Sood, Laura Damme, Ivan Netuka
AIM: This study aimed to assess safety and outcomes of patients, 2 years after implantation with the HeartMate 3 Left Ventricular Assist System. METHODS AND RESULTS: This study included 50 adults with New York Heart Association (NYHA) class IIIB or IV symptoms or American College of Cardiology/American Heart Association stage D heart failure with an ejection fraction ≤25% and a cardiac index ≤2.2 L/min/m2 without inotropes, or inotrope-dependent with optimal medical management, or listed for heart transplant...
July 27, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/30048974/understanding-left-ventricular-assist-devices
#4
REVIEW
Nadia Aissaoui, Jerome Jouan, Melissa Gourjault, Benoit Diebold, Sofia Ortuno, Amer Hamdan, Christian Latremouille, Romain Pirracchio, Michiel Morshuis
BACKGROUND/AIMS: Long-term mechanical assist devices are now commonly used in the treatment of severe heart failure to unload the failing ventricle, maintain sufficient end-organ perfusion and improve functional capacity. Depending on the assisted ventricles, 3 categories of long-term assist devices are available: left ventricular assist device (LVAD), biventricular assist device and total artificial heart. Improvements in technology, especially the advent of smaller, durable continuous flow pumps, have led to the use of LVADs in a much broader population of patients in the last 10 years...
July 26, 2018: Blood Purification
https://www.readbyqxmd.com/read/30042258/-outpatient-care-for-implantable-left-ventricular-assist-device-patients
#5
Yorihiko Matsumoto, Tomoyuki Fujita, Satsuki Fukushima, Osamu Seguchi, Masanobu Yanase, Yumiko Hori, Takako Nakaya, Norihide Fukushima, Junjirou Kobayashi
From 2005, 124 patients have received implantable left ventricular assist device (iVAD) in our institute, including HeartMate II (84), EVAHEART (17), Jarvik2000 (13), DuraHeart (9), HVAD (1). At February 2018, 60 patients were waiting for heart transplant with iVAD support. Multi-specialist team consisted of clinical engineer, VAD management specialist, nurse, transplant coordinator for recipient and physicians provide patients care. Thirty one percents returned to their social activity after iVAD implantation...
July 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/30034847/successful-establishment-of-a-left-ventricular-assist-device-program-in-an-emerging-country-one-year-experience
#6
Emilija Nestorovic, Jan D Schmitto, Sudhir S Kushwaha, Svetozar Putnik, Dusko Terzic, Natasa Milic, Aleksandar Mikic, Dejan Markovic, Danijela Trifunovic, Arsen Ristic, Miljko Ristic
Background: The primary goal of this study was to evaluate the outcomes of patients with end-stage heart failure (HF) who underwent continuous flow left ventricular assist device (CF-LVAD) in a developing country and to compare to those reported by more developed countries. The secondary goal was on determining factors that may be connected to improved survival. Methods: We prospectively analyzed 47 consecutive patients who underwent CF-LVAD at our institution. After one year the survival and adverse event profiles of patients were evaluated...
June 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/30034844/argatroban-administration-as-therapy-for-thrombosis-in-patients-with-continuous-flow-ventricular-assist-devices
#7
Leonhard Wert, Jasmin S Hanke, Günes Dogan, Marcel Ricklefs, Anamika Chatterjee, Christina Feldmann, Issam Ismail, L Christian Napp, Axel Haverich, Jan D Schmitto
Background: Device thrombosis is one of the main complications in left ventricular assist devices (LVAD) therapy and remains a challenging issue. Data on device thrombosis management, especially on the application of direct thrombin inhibitors such as argatroban, is limited and a consensus on thrombosis management has not yet been established. Methods: In this study we analysed retrospective clinical data obtained from 26 patients on VAD therapy who received argatroban for suspected VAD thrombosis, between April, 2012 and February, 2017...
June 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/30034841/minimally-invasive-surgery-improves-outcome-of-left-ventricular-assist-device-surgery-in-cardiogenic-shock
#8
Leonhard Wert, Anamika Chatterjee, Günes Dogan, Jasmin S Hanke, Dietmar Boethig, Kirstin A Tümler, L Christian Napp, Dominik Berliner, Christina Feldmann, Christian Kuehn, Andreas Martens, Malakh L Shrestha, Axel Haverich, Jan D Schmitto
Background: Left ventricular assist device (LVAD) (HVAD, Medtronic, Minneapolis, MN, USA) implantation is already a widely accepted treatment option for end-stage heart failure (HF) but also still considered as a rescue therapy for patients suffering from cardiogenic shock. Standard LVAD implantation techniques are often associated with high mortality rates and can result in severe complications, like bleeding or right heart failure (RHF). The aim of our study was to assess the outcome of Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) 1 patients (so called "crash and burn" patients) undergoing a LVAD implantation by standard or less invasive surgery...
June 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/30034840/less-invasive-heartmate-3-left-ventricular-assist-device-implantation
#9
Jan D Schmitto, Thomas Krabatsch, Laura Damme, Ivan Netuka
Background: The novel HeartMate 3 (Abbott, Chicago, IL, USA) left ventricular assist device (LVAD) was worldwide first implanted by Prof. Schmitto and his team in 2014 at the Hannover Medical School, Germany and received CE Mark approval in October, 2015 following completion of a clinical trial. Methods: Although HeartMate 3 implantation in the clinical trial was restricted to conventional sternotomy, the small size of the pump allows for less-invasive implantation, generally associated with less trauma and reduced perioperative complication rates...
June 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/30019817/impella-assisted-chronic-total-occlusion-percutaneous-coronary-interventions-a-multicenter-retrospective-analysis
#10
Robert F Riley, James M McCabe, Sanjog Kalra, Mohamad Lazkani, Ashish Pershad, Darshan Doshi, Ajay J Kirtane, William Nicholson, Katherine Kearney, Tony Demartini, J Aaron Grantham, Jeffrey Moses, William Lombardi, Dimitri Karmpaliotis
INTRODUCTION: Patients with coronary chronic total occlusions (CTO) often have concurrent higher-risk anatomy and physiology (significant calcium, left ventricular dysfunction, multivessel disease) that increase their procedural risk. We present a retrospective multicenter case series describing use of the Impella percutaneous ventricular assist device (p-VAD) during CTO PCI. METHODS: We performed a retrospective analysis of self-reported data from five large referral centers from 2013 to 2017 and identified patients that underwent elective, hemodynamically supported CTO PCI with the Impella p-VAD device (2...
July 18, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/30004942/benchtop-von-willebrand-factor-testing-comparison-of-commercially-available-ventricular-assist-devices-and-evaluation-of-variables-for-a-standardized-test-method
#11
Phillip A Coghill, Suren Kanchi, Zheila J Azartash-Namin, James W Long, Trevor A Snyder
Gastrointestinal bleeding occurs in 20-30% of patients receiving ventricular assist devices (VADs) due, in part, to acquired von Willebrand syndrome. We examined factors to optimize a benchtop method to quantify changes in von Willebrand Factor (VWF) multimer distribution and function in VADs, then applied them to evaluate commercially available devices. Human plasma was circulated through flow loops with VADs. Several experimental conditions were examined, including temperature, viscosity, and enzyme inhibition...
July 12, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29993524/viscosity-prediction-in-a-physiologically-controlled-ventricular-assist-device
#12
Anastasios Petrou, Menelaos Kanakis, Stefan Boes, Panagiotis Pergantis, Mirko Meboldt, Marianne Schmid Daners
OBJECTIVE: We present a novel machine learning model to accurately predict the blood-analog viscosity during support of a pathological circulation with a rotary ventricular assist device (VAD). The aim is the continuous monitoring of the hematocrit (HCT) of VAD patients with the benefit of a more reliable pump flow estimation and a possible early detection of adverse events, such as bleeding or pump thrombosis. METHODS: A large dataset was generated with a blood pump connected to a hybrid mock circulation by varying the pump speed, the physiological requirements of the modelled circulation, and the viscosity of the blood-analog...
January 24, 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29984811/effective-strategy-of-rescue-treatment-for-acute-pump-thrombosis-after-left-ventricular-assist-device-implantation-in-patients-with-high-risk-of-bleeding-complications
#13
Karol Wierzbicki, Izabela Górkiewicz-Kot, Anna Kędziora, Maciej Stąpór, Dorota Sobczyk, Hubert Hymczak, Irena Milaniak, Michał Kaleta, Jacek Piątek, Bogusław Kapelak
No abstract text is available yet for this article.
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29968261/predictive-value-of-preoperative-serum-albumin-levels-on-outcomes-in-patients-undergoing-lvad-implantation
#14
Andre C Critsinelis, Chitaru Kurihara, Masashi Kawabori, Tadahisa Sugiura, Vei-Vei Lee, Andrew B Civitello, Jeffrey A Morgan
BACKGROUND: We performed a single-center retrospective analysis to determine whether preoperative serum albumin levels were associated with postoperative adverse events and short- and long-term survival in patients who underwent continuous-flow left ventricular assist device (CF-LVAD) implantation. METHODS: From November 2003 through March 2016, 526 patients underwent CF-LVAD implantation. Patients whose preoperative serum albumin level was normal (≥3.5 g/dL) were compared to patients with preoperative hypoalbuminemia (<3...
July 2, 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29960661/hospital-complications-and-causes-of-90-day-readmissions-after-implantation-of-left-ventricular-assist-devices
#15
Byomesh Tripathi, Shilpkumar Arora, Varun Kumar, Kamia Thakur, Sopan Lahewala, Nileshkumar Patel, Mihir Dave, Mahek Shah, Sejal Savani, Purnima Sharma, Dhrubajyoti Bandyopadhyay, Ghanshyam Palamaner Subash Shantha, Alexander Egbe, Saurav Chatterjee, Nimesh Kirit Patel, Radha Gopalan, Vincent M Figueredo, Abhishek Deshmukh
Left ventricular assist devices (LVADs) have emerged as an attractive option in patients with advance heart failure. Nationwide readmission database 2013 to 2014 was utilized to identify LVAD recipients using ICD-9 procedure code 37.66. The primary outcome was 90-day readmission. Readmission causes were identified using ICD-9 codes in primary diagnosis field. The secondary outcomes were LVAD associated with hospital complications. Hierarchic 2-level logistic models were used to evaluate study outcomes. We identified 4,693 LVAD recipients (mean age 57years, 76...
May 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29921985/high-molecular-weight-von-willebrand-factor-multimer-loss-and-bleeding-in-patients-with-short-term-mechanical-circulatory-support-devices-a-case-series
#16
Michael Goldfarb, Lawrence S Czer, Lee D Lam, Jaime Moriguchi, Francisco A Arabia, Oksana Volod
Acquired von Willebrand syndrome (VWS) due to loss of high-molecular-weight multimers (HMWMs) has been reported with longer term mechanical devices and is associated with mucosal bleeding, a primary hemostasis type of bleeding. However, little is known whether a similar defect occurs in patients with short-term mechanical circulatory support (STMCS) devices. We reviewed von Willebrand factor (VWF) profiles in patients with STMCS devices who underwent VWS workup from December 2015 to March 2017 at an academic quaternary care hospital...
June 2018: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/29907499/incidence-of-temporary-mechanical-circulatory-support-before-heart-transplantation-and-impact-on-post-transplant-outcomes
#17
David Ouyang, Gunsagar Gulati, Richard Ha, Dipanjan Banerjee
BACKGROUND: Proposed changes to the United Network for Organ Sharing heart transplant allocation protocol will prioritize patients receiving temporary mechanical circulatory support (tMCS), including extracorporeal membrane oxygenation (ECMO), percutaneous ventricular assist devices (PVADs), and intra-aortic balloon pumps (IABPs). We sought to evaluate contemporary trends in the incidence and outcomes of patients who required tMCS during the hospitalization before heart transplantation...
April 26, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29906524/timing-of-gastrointestinal-bleeding-after-implantation-of-left-ventricular-assist-devices-associates-with-anatomic-location-presentation-and-management
#18
James H Tabibian, Daniel P Rhoades, Kimberly A Forde, Rhondalyn C McLean, Vinay Chandrasekhara
BACKGROUND & AIMS: Continuous-flow left ventricular assist devices (LVADs) for advanced heart failure have been associated with gastrointestinal bleeding (GIB). We examined the association between time of GIB after LVAD implantation and bleeding location (determined by endoscopy), etiology, and patient outcomes. METHODS: We performed a retrospective study of consecutive patients who underwent implantation of continuous-flow LVADs from 2008 through 2015. We analyzed data on anatomic location of GIB, etiology, length of hospital stay, transfusion requirement, time to endoscopy, and rate of readmission within 30 days...
June 12, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29903893/living-without-a-pulse-the-vascular-implications-of-continuous-flow-left-ventricular-assist-devices
#19
Suneet N Purohit, William K Cornwell, Jay D Pal, JoAnn Lindenfeld, Amrut V Ambardekar
Pulsatility seems to have a teleological role because evolutionary hierarchy favors higher ordered animals with more complex, multichamber circulatory systems that generate higher pulse pressure compared with lower ordered animals. Yet despite years of such natural selection, the modern generation of continuous-flow left ventricular assist devices (CF-LVADs) that have been increasingly used for the last decade have created a unique physiology characterized by a nonpulsatile, nonlaminar blood flow profile with the absence of the usual large elastic artery Windkessel effect during diastole...
June 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29879864/utility-of-the-psychosocial-assessment-of-candidates-for-transplantation-in-patients-undergoing-continuous-flow-left-ventricular-assist-device-implantation
#20
Meghana Halkar, Amy S Nowacki, Kay Kendall, Nephertiti Efeovbokhan, Eiran Z Gorodeski, Nader Moazami, Randall C Starling, James B Young, Sangjin Lee, W H Wilson Tang
PURPOSE: Psychosocial assessment of patients comprises an important element in the selection process of appropriate candidates for left ventricular assist device (LVAD) implantation. We sought to determine the association of the well-validated psychosocial assessment of candidates for transplantation (PACT) scale to clinical outcomes post-LVAD implantation. MATERIALS AND METHODS: The PACT scale was used retrospectively to reconstruct psychosocial profiles of all patients who underwent a continuous-flow LVAD implantation for all indications at our institution between March 2008 and August 2012 (N = 230)...
January 1, 2018: Progress in Transplantation
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