Zahid Nawaz, Naheed Riaz, Muhammad Saleem, Ambar Iqbal, Syeda Abida Ejaz, Bushra Bashir, Saima Muzaffar, Muhammad Ashraf, Aziz-Ur-Rehman, Muhammad Sajjad Bilal, Bala Krishna Prabhala, Salvia Sajid
Inflammation is a multifaceted phenomenon triggered by potentially active mediators acutely released arachidonic acid metabolites partially in lipoxygenase (LOX) pathway which are primarily accountable for causing several diseases in humans. It is widely believed that an inhibitor of the LOX pathway represents a rational approach for designing more potent antiinflammatory leads with druggable super safety profiles. In our continual efforts in search for anti-LOX molecules, the present work was to design a new series of N-alkyl/aralkyl/aryl derivatives (7a-o) of 4-phenyl-5-(1-phenylcarbamoylpiperidine)-4H-1,2,4-triazole-3-thiol which was commenced in seriate formation of phenylcarbamoyl derivative (1), hydrazide (2), semicarbazide (3) and 4-phenyl-5-(1-phenylcarbamoylpiperidine)-4H-1,2,4-triazole-3-thiol (4)...
November 23, 2023: Bioorganic Chemistry