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Atrial Fibrillation And Gender

Joshua Payne, Samuel Aznaurov, Sandeep Gautam
BACKGROUND: Figure-of-Eight sutures (F8S) have emerged as an alternative to the standard practice of manual compression to achieve venous hemostasis after catheter ablation for atrial fibrillation (AF). In lieu of a knot to secure the sutures in place, a three-way stopcock can be used that can be loosened or tightened as needed to achieve hemostasis and is easier to remove. The safety and effectiveness of this technique when compared to traditional F8S is unknown. In this case series, we sought to describe this stopcock closure technique (SC) and compare procedural characteristics and outcomes to traditional F8S...
August 14, 2018: Journal of Cardiovascular Electrophysiology
Ajmer Singh, Yatin Mehta
Heart failure (HF) is a complex clinical syndrome that results from any structural or functional impairment of ventricular filling or ejection of blood. American College of Cardiology Foundation / American Heart Association 2013 guidelines have classified HF into two categories: (i) HF with reduced (≤40%) ejection fraction (HFrEF) or systolic HF, and (ii) HF with preserved (≥50%) ejection fraction (HFpEF) or diastolic HF. Risk factors for HFpEF include age more than 70 years, female gender, hypertension, wide pulse pressure, diabetes mellitus, chronic renal insufficiency, left ventricular hypertrophy, atrial fibrillation, smoking, recent weight gain, and exercise intolerance...
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
Edward Koźluk, Dorota Zyśko, Agnieszka Piątkowska, Marek Kiliszek, Piotr Lodziński, Sylwia Małkowska, Paweł Balsam, Dariusz Rodkiewicz, Małgorzata Żukowska, Grzegorz Opolski
BACKGROUND: Atrial fibrillation (AF) is a common clinical problem. The left atrium anatomy makes up a factor that may significantly affect the effectiveness of the AF ablation. OBJECTIVES: The aim of the study was to evaluate a long-term effectiveness ablation in patients with common pulmonary vein trunk (CPVT) and AF. MATERIAL AND METHODS: The outcomes of 129 procedures in 95 patients with CPVT out of 1,475 procedures carried out in 1,150 patients with AF treated with ablation, were analyzed...
August 8, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Boqia Xie, Bi-Xi Chen, Jiao-Yan Wu, Xingpeng Liu, Min-Fu Yang
BACKGROUND: This retrospective study was designed to explore the factors relevant to increased atrial 18 F-fluorodeoxyglucose (FDG) uptake in patients with atrial fibrillation (AF) who had undergone routine whole-body positron emission tomography/computed tomography (PET/CT) imaging. METHODS AND RESULTS: Forty-eight consecutive AF patients (32 persistent, 16 paroxysmal) were identified from our routine FDG PET/CT database. Twenty-two control subjects were selected to establish the normal range of FDG uptake (maximum standardized uptake value, SUVmax ) in target tissues...
August 7, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Barış Şimşek, Servet Altay, Nazmiye Özbilgin, Altan Onat
Although low-grade inflammation has been linked to the prediction of atrial fibrillation (AF), evidence from some reports suggest that autoimmune activation might potentially be a relevant mechanism. We assessed the predictive value of inflammation and other markers for the risk of incident AF.A score of age-controlled anthropometric, lipid, and nonlipid variables was compared in participants with recorded nonvalvular persistent/permanent AF (n = 110) to those of a nested cohort sample (n = 1126) of the Turkish Adult Risk Factor study...
August 2018: Medicine (Baltimore)
Abdullah Nabi Aslan, Serdal Baştuğ, Hacı Ahmet Kasapkara, Murat Can Güney, Serkan Sivri, Engin Bozkurt
Background: Ischemia of the atria and conductive system of the heart results in greater atrial electrophysiological changes and propensity for atrial fibrillation. P wave duration and dispersion have been proposed to be useful for the prediction of paroxysmal atrial fibrillation (PAF). This study aimed to investigate the effect of coronary artery dominance on P wave duration and dispersion. Methods: The study population included 194 patients with left dominant circulation (LDC) and 200 age- and gender-matched controls with right dominant circulation (RDC) and without coronary artery disease based on invasive coronary angiography findings...
July 2018: Acta Cardiologica Sinica
Fan Wang, Mengyun Zhu, Xiaoyu Wang, Wei Zhang, Yang Su, Yuyan Lu, Xin Pan, Di Gao, Xianling Zhang, Wei Chen, Yawei Xu, Yuxi Sun, Dachun Xu
BACKGROUND: Left atrial appendage morphology has been proved to be an important predictor of left atrial thrombus (LAT) and left atrial spontaneous echo contrast (LASEC) and stroke in patients with non-valvular atrial fibrillation (NVAF). However, the relation between left atrial appendage (LAA) lobes and LAT or LASEC is still unknown. The aim of this study is to investigate the correlation between the number of left atrial appendage lobes and LAT/LASEC in patients with NVAF. METHODS: This monocentric cross-sectional study enrolled 472 consecutive patients with non-valvular atrial fibrillation, who had transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) prior to cardioversion or left atrial appendage closure (LAAC) from July 2009 to August 2015 in department of cardiology of Shanghai Tenth People's Hospital...
July 31, 2018: BMC Cardiovascular Disorders
Xin-Hua Wang, Zheng Li, Jia-Liang Mao, Min-Hua Zang, Jun Pu
BACKGROUND: The prevalence, risk factors of left atrial low voltage areas (LVA) in paroxysmal atrial fibrillation (PAF) and the impact of LVA on the effectiveness of circumferential pulmonary vein isolation (CPVI) were not fully clarified. METHODS: One hundred fifty patients (mean age 64.7 years, 89 males) with PAF were consecutively enrolled to undergo CPVI. Prior to ablation a contact force sensing ablation catheter was utilized for LVA mapping in sinus rhythm...
July 19, 2018: International Journal of Cardiology
Tetsuma Kawaji, Satoshi Shizuta, Shintaro Yamagami, Takanori Aizawa, Takashi Yoshizawa, Masashi Kato, Takafumi Yokomatsu, Shinji Miki, Koh Ono, Takeshi Kimura
BACKGROUND: The incidence of subsequent need for permanent pacemaker implantation (PMI) after radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF) in real world patients with and without pre-existing bradycardia has not yet been fully evaluated.Methods and Results:A total of 1,131 consecutive patients undergoing first-time RFCA for AF who had no previous or planned device implantation, were enrolled in the present study. Of 799 paroxysmal AF (PAF) patients, 121 (15...
July 27, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Fei Fei Gong, Michael V Jelinek, Julian M Castro, Jennifer M Coller, Michele McGrady, Umberto Boffa, Louise Shiel, Danny Liew, Rory Wolfe, Simon Stewart, Alice J Owen, Henry Krum, Christopher M Reid, David L Prior, Duncan J Campbell
Background: The lack of effective therapies for heart failure with preserved ejection fraction (HFpEF) reflects an incomplete understanding of its pathogenesis. Design: We analysed baseline risk factors for incident HFpEF, heart failure with reduced ejection fraction (HFrEF) and valvular heart failure (VHF) in a community-based cohort. Methods: We recruited 2101 men and 1746 women ≥60 years of age with hypertension, diabetes, ischaemic heart disease (IHD), abnormal heart rhythm, cerebrovascular disease or renal impairment...
2018: Open Heart
A John Camm, Pierre Amarenco, Sylvia Haas, Susanne Hess, Paulus Kirchhof, Marc Lambelet, Miriam Bach, Alexander G G Turpie
Aims: Based on Phase III data, non-vitamin K antagonist oral anticoagulants are recommended for stroke prevention in patients with atrial fibrillation. To determine whether trial outcomes translate into similar event rates in unselected patients, this analysis compared outcomes from the real-world XANTUS study with those from the Phase III ROCKET AF study. Methods and results: Individual patient data from 4020 XANTUS patients were re-weighted to match the proportion of selected baseline characteristics in 7061 rivaroxaban-treated patients from ROCKET AF, using the matching-adjusted indirect comparison (MAIC) method...
July 19, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Tero Penttilä, Mika Lehto, Jussi Niiranen, Juha Mehtälä, Houssem Khanfir, Riitta Lassila, Pekka Raatikainen
Aims: Females with atrial fibrillation (AF) have been suggested to carry a higher risk for thromboembolic events than males. We compared the residual risk of stroke, bleeding events, and cardiovascular and all-cause mortality among female and male AF patients taking warfarin. Methods and results: Data from several nationwide registries and laboratory databases were linked with the civil registration number of the patients. A total of 54568 patients with data on the quality of warfarin treatment (time in therapeutic range) 60 days prior to the events were included (TTR60)...
July 21, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
Aurangzeb Memon, Louise D McCullough
Despite several advancements in stroke care, disparities continue to exist with regard to sex differences in cerebrovascular disease. These sex differences are due to a combination of several factors, many of which are unique to the female sex. Some of these unique factors, such as pregnancy and menopause, are related to hormonal changes seen throughout the female life cycle. Hormonal fluctuations, which impact the protective effects of the female sex hormones, can be induced by the use of hormonal contraception...
2018: Advances in Experimental Medicine and Biology
Marek Sramko, Dan Wichterle, Vojtech Melenovsky, Janka Franekova, Marcell Clemens, Masato Fukunaga, Josef Kautzner
BACKGROUND: We investigated whether the increase of plasma natriuretic peptides (NPs) in atrial fibrillation (AF) is independent of the effect of AF on the left atrial (LA) hemodynamics. METHODS: Hemodynamically stable patients scheduled for AF ablation underwent assessment of B-type natriuretic peptide (BNP) and mid-regional pro-atrial natriuretic peptide (MR-proANP), echocardiography, and direct measurement of left atrial (LA) pressure. Concentrations of the NPs were compared between patients in AF (n = 31) and controls in sinus rhythm (SR; n = 31) who were matched for age, gender, heart rate, left ventricular ejection fraction, LA volume index, and directly measured mean LA pressure...
July 26, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Robert C Bahler, Riem Hawi, Aleksandr Rovner, Robert S Finkelhor, Charles L Thomas, Neal V Dawson
Outcomes in asymptomatic patients with aortic stenosis (AS) have been reported primarily from tertiary centers. Whether observations from a community hospital cohort would be similar or if clinical variables would assume a more important role remains uncertain. This retrospective cohort study from one community hospital followed asymptomatic patients with moderate to severe AS for 3 years following an index echocardiogram. Patients underwent standard echocardiographic imaging and assessment of AS severity...
June 4, 2018: American Journal of Cardiology
M Korhonen, P Mustonen, M Hedman, J Vienonen, J Onatsu, R Vanninen, M Taina
AIM: To evaluate whether certain morphological features of the left atrial appendage (LAA) would influence the LAA/ascending aorta (AA) radiodensity ratio, as a reflection of the blood flow conditions in the LAA. MATERIALS AND METHODS: Eight-hundred and eight consecutive patients undergoing computed tomography angiography (CCTA) were evaluated. Of these, 749 had no history of atrial fibrillation and none had suffered acute stroke. The LAA/AA radiodensity ratio, and the length, lobe number, and morphological classification of LAAs were assessed...
July 17, 2018: Clinical Radiology
Irene Marzona, Marco Proietti, Alessio Farcomeni, Giulio Francesco Romiti, Imma Romanazzi, Valeria Raparelli, Stefania Basili, Gregory Y H Lip, Alessandro Nobili, Maria Carla Roncaglioni
BACKGROUND: Atrial fibrillation (AF) is the most commonly diagnosed arrhythmia, which is associated with an increased risk of stroke. Several studies have suggested that female AF patients could have a greater risk for stroke and thromboembolic events (TE). METHODS: A systematic literature review update and meta-analysis was conducted using Pubmed. The search used the terms "atrial fibrillation", "gender", "sex", "female", "women", "stroke", "thromboembolism"...
July 9, 2018: International Journal of Cardiology
Chung-Yu Chen, Kuang-Ming Liao
Background: Atrial fibrillation (AF) occurs frequently in patients with COPD. There are limited data about the impact of AF in hospitalized COPD patients on other serious health outcomes, such as acute organ dysfunction, severe sepsis, and respiratory failure. The aim of our study was to delineate the impact of AF in hospitalized COPD patients. Methods: We defined COPD populations with and without AF from the National Health Insurance database in Taiwan. The control subjects (patients with COPD without AF) were selected from the population of COPD patients who had no history of AF and were matched to the COPD patients with AF by age (±1 year), gender, and the year of COPD diagnosis (±1 year)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Manfred Berger, Meryem Emir, Tanja Brünnler, Felix Rockmann, Ralf Lehmann
BACKGROUND: Aim of this study was to evaluate the predictors of hs-cTnT in a non-ACS patient cohort admitted to the emergency department. METHOD: We performed a retrospective, single centre study encompassing in total 1003 patients. Individuals were retrospectively divided in ACS- and non-ACS patients by two independent investigators reviewing the medical records. In order to identify predictors of hs-cTnT elevation hazard ratios were calculated for age, gender, vital signs, cardiovascular risk factors, LVEF, serum levels of CRP, haemoglobin, and creatinine...
July 17, 2018: Clinical Cardiology
Bradley J Petek, Meagan M Wasfy
PURPOSE OF REVIEW: The number of female athletes participating in sports has increased exponentially over the past century. While cardiac adaptations to exercise have been well described, female athletes have been underrepresented in many prior studies. More recently, important research has embraced gender as an important biologic variable. We will review this work in order to examine how gender influences the impact of exercise on the heart. RECENT FINDINGS: Exercise-induced cardiac remodeling (EICR) manifests slightly differently in male and female athletes...
July 18, 2018: Current Treatment Options in Cardiovascular Medicine
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