Read by QxMD icon Read


Adriana Czerwik, Marta Płonek, Przemyslaw Podgórski, Marcin Wrzosek
BACKGROUND: In humans, temporal lobe epilepsy (TLE), is a type of focal epilepsy occurring mainly in the mesial TLE (mTLE), commonly associated with hippocampal sclerosis (HS). OBJECTIVES: According to recent studies, TLE might also occur in dogs and could be associated with hippocampal atrophy (HA)/HS. To date, hippocampal lesions have not been correlated with electroencephalographic (EEG) findings in epileptic dogs. ANIMALS: An EEG examination, brain magnetic resonance imaging, and volumetric assessment of the hippocampus were performed in 16 nonepileptic and 41 epileptic dogs...
October 16, 2018: Journal of Veterinary Internal Medicine
Siti Nurbaya Yaakub, Gareth J Barker, Sarah J Carr, Eugenio Abela, Michalis Koutroumanidis, Robert D C Elwes, Mark P Richardson
We investigated gray and white matter morphology in patients with mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE+HS) and first-degree asymptomatic relatives of patients with mTLE+HS. Using T1-weighted magnetic resonance imaging (MRI), we sought to replicate previously reported findings of structural surface abnormalities of the anterior temporal lobe in asymptomatic relatives of patients with mTLE+HS in an independent cohort. We performed whole-brain MRI in 19 patients with mTLE+HS, 14 first-degree asymptomatic relatives of mTLE+HS patients, and 32 healthy control participants...
October 15, 2018: Epilepsia
Yoshihiro Noda, Reza Zomorrodi, Zafiris J Daskalakis, Daniel M Blumberger, Motoaki Nakamura
The underlying mechanism of repetitive transcranial magnetic stimulation (rTMS) effects on cognition has not been fully examined. Previously, we have reported the left hippocampal volume increase and theta-gamma coupling (TGC) enhancement associated with working memory improvement following rTMS in depression. This study was aimed to examine whether there is a structure-function relationship in hippocampal neuroplasticity induced by prefrontal rTMS. Thirty-one patients with major depression underwent longitudinal MRI scans and resting-state EEG recordings with the 10-20 system using averaged ear-lobes reference, following 10 sessions of high-frequency rTMS over the left dorsolateral prefrontal cortex...
November 2018: International Journal of Psychophysiology
Carolina Abulafia, David Loewenstein, Rosie Curiel-Cid, Bárbara Duarte-Abritta, Stella M Sánchez, Daniel E Vigo, Mariana N Castro, Lucas J Drucaroff, Silvia Vázquez, Gustavo Sevlever, Charles B Nemeroff, Salvador M Guinjoan, Mirta F Villarreal
Failure to recover from proactive semantic interference (frPSI) has been shown to be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer's disease. The authors sought to characterize the structural and amyloid in vivo correlates of frPSI in cognitively normal offspring of patients with late-onset Alzheimer's disease (O-LOAD), compared with individuals without a family history of neurodegenerative disorders (CS). The authors evaluated the LASSI-L, a test tapping frPSI and other types of semantic interference and delayed recall on the RAVLT, along with 3-T MRI volumetry and positron emission tomography Pittsburgh compound B, in 27 O-LOAD and 18 CS with equivalent age, sex, years of education, ethnicity, premorbid intelligence, and mood symptoms...
October 11, 2018: Journal of Neuropsychiatry and Clinical Neurosciences
Akifumi Hagiwara, Masaaki Hori, Julien Cohen-Adad, Misaki Nakazawa, Yuichi Suzuki, Akihiro Kasahara, Moeko Horita, Takuya Haruyama, Christina Andica, Tomoko Maekawa, Koji Kamagata, Kanako Kunishima Kumamaru, Osamu Abe, Shigeki Aoki
OBJECTIVES: The aim of this study was to evaluate the linearity, bias, intrascanner repeatability, and interscanner reproducibility of quantitative values derived from a multidynamic multiecho (MDME) sequence for rapid simultaneous relaxometry. MATERIALS AND METHODS: The NIST/ISMRM (National Institute of Standards and Technology/International Society for Magnetic Resonance in Medicine) phantom, containing spheres with standardized T1 and T2 relaxation times and proton density (PD), and 10 healthy volunteers, were scanned 10 times on different days and 2 times during the same session, using the MDME sequence, on three 3 T scanners from different vendors...
September 5, 2018: Investigative Radiology
Yael Eshet, Erez Nissim Baruch, Ronnie Shapira-Frommer, Yael Steinberg-Silman, Teodor Kuznetsov, Guy Ben-Betzalel, Sameh Daher, Iris Gluck, Nethanel Asher, Sara Apter, Jacob Schachter, Jair Bar, Ben Boursi, Gal Markel
Immune checkpoint inhibitor (ICI)-related diarrhea is attributed to inflammatory colitis, with no other drug-related differential diagnosis. Here, we investigated the occurrence of pancreatic atrophy (PA) in ICI-treated cancer patients and its correlation to exocrine pancreatic insufficiency (EPI). Metastatic melanoma, non-small cell lung carcinoma, and head & neck squamous cell carcinoma patients (n=403) treated with anti-PD-1 (n=356) or anti-CTLA-4 (n=47) were divided into a Case group (radiological evidence of PA), Control group matched by age, gender, and previous lines of treatment, and Colitis group (ICI-induced colitis)...
October 1, 2018: Cancer Immunology Research
Martin Jakobs, Jessica Jesser, Tobias Albrecht, Antje Wick, Andreas Unterberg, Rezvan Ahmadi
INTRODUCTION: Sphenopalatine ganglion stimulation (SPG-S) is an invasive form of neuromodulation by which a neurostimulator is implanted into the pterygopalatine fossa to treat refractory chronic cluster headache. The implant is MRI conditional, up to 3 T, however there is no clinical data on the shape, size, and location of the artifact produced by the implant. MATERIALS AND METHODS: Records of patients with SPG-S were analyzed for postoperative cranial MRI scans...
September 30, 2018: Neuromodulation: Journal of the International Neuromodulation Society
Eberhard Rabe, Patrick Carpentier, Arnaud Maggioli
The aim of this review was to discuss the different techniques of leg edema measurement that have been used in clinical trials to help determine the most appropriate method of assessment and quantification for use in future research. Venoactive drugs such as micronized purified flavonoid fraction (MPFF) are established agents for the treatment of venous leg edema, but results from randomized- controlled trials vary depending on the method of edema assessment. The medical literature was searched for published articles using the terms venous lower limb edema and method of edema assessment...
September 24, 2018: International Angiology: a Journal of the International Union of Angiology
Anthony Merlocco, Russell R Cross, Peter Kellman, Hui Xue, Laura Olivieri
BACKGROUND: Myocardial strain is an important measure of cardiac function and can be assessed on cardiac magnetic resonance (MR) through the current gold standard of breath-held segmented steady-state free precession (SSFP) cine imaging. Novel free-breathing techniques have been validated for volumetry and systolic function, allowing for evaluation of sicker and younger children who cannot reliably hold their breath. It is unclear whether strain measurements can be reliably performed on free-breathing, motion-corrected, re-binning cine images...
September 22, 2018: Pediatric Radiology
Chunjie Guo, Daniel Ferreira, Katarina Fink, Eric Westman, Tobias Granberg
OBJECTIVES: To compare the cross-sectional robustness of commonly used volumetric software and effects of lesion filling in multiple sclerosis (MS). METHODS: Nine MS patients (six females; age 38±13 years, disease duration 7.3±5.2 years) were scanned twice with repositioning on three MRI scanners (Siemens Aera 1.5T, Avanto 1.5T, Trio 3.0T) the same day. Volumetric T1 -weighted images were processed with FreeSurfer, FSL-SIENAX, SPM and SPM-CAT before and after 3D FLAIR lesion filling with LST...
September 21, 2018: European Radiology
S Schindler, L Schmidt, M Stroske, M Storch, A Anwander, R Trampel, M Strauß, U Hegerl, S Geyer, P Schönknecht
OBJECTIVE: The purpose of this study was to determine, in vivo, whether the hypothalamus volume is reduced in patients with mood disorders. METHODS: The cross-sectional study included 20 unmedicated (MDDu) and 20 medicated patients with major depressive disorder, 21 patients with bipolar disorder, and 23 controls. Twenty of the controls were matched to the MDDu. Seven Tesla, T1-weighted magnetic resonance images were acquired and processed using methods specifically developed for high-precision volumetry of the hypothalamus...
September 19, 2018: Acta Psychiatrica Scandinavica
Marthony Robins, Jayashree Kalpathy-Cramer, Nancy A Obuchowski, Andrew Buckler, Maria Athelogou, Rudresh Jarecha, Nicholas Petrick, Aria Pezeshk, Berkman Sahiner, Ehsan Samei
RATIONALE AND OBJECTIVES: To evaluate a new approach to establish compliance of segmentation tools with the computed tomography volumetry profile of the Quantitative Imaging Biomarker Alliance (QIBA); and determine the statistical exchangeability between real and simulated lesions through an international challenge. MATERIALS AND METHODS: The study used an anthropomorphic phantom with 16 embedded physical lesions and 30 patient cases from the Reference Image Database to Evaluate Therapy Response with pathologically confirmed malignancies...
September 12, 2018: Academic Radiology
Gilles Straub, Claudio Caviezel, Thomas Frauenfelder, Konrad E Bloch, Daniel Franzen
Surgical and bronchoscopic lung volume reduction (LVR) have been demonstrated to improve lung function, dyspnea and quality of life in patients with severe pulmonary emphysema. The most important functional prerequisite for a successful LVR is hyperinflation measured by body plethysmography. A residual volume (RV) of more than 180% predicted and a RV/total lung capacity (TLC) ratio of more than 0.58 were inclusion criteria in major LVR trials. Here we report a successful LVR in a 68-year-old man with advanced, heterogeneous emphysema without plethysmographic evidence of severe hyperinflation (RV/TLC 0...
August 2018: Journal of Thoracic Disease
Petra Steinacker, Sarah Anderl-Straub, Janine Diehl-Schmid, Elisa Semler, Ingo Uttner, Christine A F von Arnim, Henryk Barthel, Adrian Danek, Klaus Fassbender, Klaus Fliessbach, Hans Foerstl, Timo Grimmer, Hans-Jürgen Huppertz, Holger Jahn, Jan Kassubek, Johannes Kornhuber, Bernhard Landwehrmeyer, Martin Lauer, Juan Manuel Maler, Benjamin Mayer, Patrick Oeckl, Johannes Prudlo, Anja Schneider, Alexander E Volk, Jens Wiltfang, Matthias L Schroeter, Albert C Ludolph, Markus Otto
OBJECTIVE: To determine the association of serum neurofilament light chain (NfL) with functional deterioration and brain atrophy during follow-up of patients with behavioral variant frontotemporal dementia (bvFTD). METHODS: Blood NfL levels from 74 patients with bvFTD, 26 with Alzheimer disease (AD), 17 with mild cognitive impairment (MCI), and 15 healthy controls (Con) at baseline and follow-up were determined and analyzed for the diagnostic potential in relation to functional assessment (Clinical Dementia Rating Scale Sum of Boxes [CDR-SOB], frontotemporal lobar degeneration-related CDR-SOB, Mini-Mental State Examination [MMSE]) and brain volumetry...
September 12, 2018: Neurology
Yosuke Mitsui, Takuya Sadahira, Motoo Araki, Yuki Maruyama, Koichiro Wada, Ryuta Tanimoto, Yasuyuki Kobayashi, Masami Watanabe, Toyohiko Watanabe, Yasutomo Nasu
BACKGROUND: Excessive visceral fat may decrease renal function because of metabolic derangements. The aim of this study was to evaluate the impact of abdominal fat distribution on renal function of recipients after kidney transplantation using the visceral adipose tissue (VAT)/subcutaneous adipose tissue (SAT) ratio. METHODS: Seventy-nine patients underwent living kidney transplantation from 2009 to 2017. Patients without a correct measurement of VAT and SAT, follow-up of < 6 months, or with kidney transplant rejection or a virus infection were excluded...
September 6, 2018: Clinical and Experimental Nephrology
Jill Abrigo, Lin Shi, Yishan Luo, Qianyun Chen, Winnie Chiu Wing Chu, Vincent Chung Tong Mok
Background One significant barrier to incorporate Alzheimer's disease (AD) imaging biomarkers into diagnostic criteria is the lack of standardized methods for biomarker quantification. The European Alzheimer's Disease Consortium-Alzheimer's Disease Neuroimaging Initiative (EADC-ADNI) Harmonization Protocol project provides the most authoritative guideline for hippocampal definition and has produced a manually segmented reference dataset for validation of automated methods. Purpose To validate automated hippocampal volumetry using AccuBrain™, against the EADC-ADNI dataset, and assess its diagnostic performance for differentiating AD and normal aging in an independent cohort...
September 5, 2018: Acta Radiologica
S Fjalldal, C Follin, S Gabery, P C Sundgren, I M Björkman-Burtscher, J Lätt, P Mannfolk, C H Nordström, L Rylander, B Ekman, R Cheong, A Pålsson, Å Petersén, E M Erfurth
BACKGROUND/OBJECTIVES: Hypothalamic obesity (HO) occurs in 50% of patients with the pituitary tumor craniopharyngioma (CP). Attempts have been made to predict the risk of HO based on hypothalamic (HT) damage on magnetic resonance imaging (MRI), but none have included volumetry. We performed qualitative and quantitative volumetric analyses of HT damage. The results were explored in relation to feeding related peptides and body fat. SUBJECTS/METHODS: A cross-sectional study of childhood onset CPs involving 3 Tesla MRI, was performed at median 22 years after first operation; 41 CPs, median age 35 (range: 17-56), of whom 23 had HT damage, were compared to 32 controls...
September 4, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Dennis M Hedderich, Judith E Spiro, Oliver Goldhardt, Johannes Kaesmacher, Benedikt Wiestler, Igor Yakushev, Claus Zimmer, Tobias Boeckh-Behrens, Timo Grimmer
BACKGROUND: Volumetric quantification of structural MRI has been shown to increase the diagnostic accuracy of patients with mild cognitive impairment (MCI); however, its implementation in clinical routine is usually technically difficult and time-consuming. OBJECTIVE: The purpose of this study was to investigate whether volumetric information obtained from the free and easy-to-use online tool volBrain can improve correct identification of MCI patients with Alzheimer's disease (AD) compared to visual reading...
2018: Journal of Alzheimer's Disease: JAD
Hiroyuki Tao, Masataro Hayashi, Masashi Furukawa, Ryohei Miyazaki, Shintaro Yokoyama, Akio Hara, Kazunori Okabe
OBJECTIVES: We previously reported that the use of a stapler to divide intersegmental planes did not decrease preserved pulmonary volume or function relative to electrocautery. However, preservation of pulmonary volume or function can be compromised when a stapler is used with larger intersegmental planes. Here, we assessed the correlations between preserved lung volume and pulmonary function after segmentectomy and the size of the intersegmental planes, based on the division method. METHODS: Intersegmental plane sizes in 56 patients were semi-automatically calculated using image analysis software on computed tomography images...
August 30, 2018: General Thoracic and Cardiovascular Surgery
Michael Paks, Paul Leong, Paul Einsiedel, Louis B Irving, Daniel P Steinfort, Diane M Pascoe
Solid pulmonary nodules are a common finding requiring serial computed tomography (CT) imaging. We sought to explore the detection and measurement accuracy of an ultralow-dose CT (ULDCT) protocol compared with our standard low-dose CT (LDCT) nodule follow-up protocol.In this pragmatic single-center pilot prospective cohort study, patients scheduled for clinically indicated CT surveillance of 1 or more known solid pulmonary nodules >2 mm underwent ULDCT immediately after routine LDCT. The Bland-Altman 95% limits of agreement for diameter and volumetry were calculated...
August 2018: Medicine (Baltimore)
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"