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Norbert Brüggemann, Aloysius Domingo, Dirk Rasche, Christian K E Moll, Raymond L Rosales, Roland Dominic G Jamora, Henrike Hanssen, Alexander Münchau, Julia Graf, Anne Weissbach, Vera Tadic, Cid C Diesta, Jens Volkmann, Andrea Kühn, Thomas F Münte, Volker Tronnier, Christine Klein
Importance: Anecdotal evidence suggests that deep brain stimulation (DBS) of the internal globus pallidus (GPi) is effective in ameliorating dystonia in X-linked dystonia parkinsonism (XDP), a disease that is usually refractive to medical therapy. Objective: To determine the efficacy of GPi-DBS in a cohort of patients with XDP in a prospective study and identify predictors of postoperative outcomes. Design, Setting, and Participants: This observational prospective cohort study enrolled patients in February 2013 and was completed in December 2014...
December 3, 2018: JAMA Neurology
Florian Siedek, Stefan Haneder, Jonas Dörner, John N Morelli, Seung-Hun Chon, David Maintz, Christian Houbois
PURPOSE: This study aims to determine whether contrast-enhanced (CE)-magnetic resonance imaging (MRI) is comparable to CE-computed tomography (CT) for estimation of split renal function (SRF). For this purpose, two different kidney volumetry methods, the renal cortex volumetry (RCV) and modified ellipsoid volume (MELV), are compared for both acquisition types (CT vs. MRI) with regard to accuracy and reliability, subsequently referred to as RCVCT /RCVMRI and MELVCT /MELVMRI . METHODS: This retrospective study included 29 patients (18 men and 11 women; mean age 62...
December 1, 2018: Abdominal Radiology
Sonja Schönecker, Franz Hell, Kai Bötzel, Elisabeth Wlasich, Nibal Ackl, Christine Süßmair, Markus Otto, Sarah Anderl-Straub, Albert Ludolph, Jan Kassubek, Hans-Jürgen Huppertz, Janine Diehl-Schmid, Lina Riedl, Carola Roßmeier, Klaus Fassbender, Epameinondas Lyros, Johannes Kornhuber, Timo Jan Oberstein, Klaus Fliessbach, Anja Schneider, Matthias L Schroeter, Johannes Prudlo, Martin Lauer, Holger Jahn, Johannes Levin, Adrian Danek
The applause sign, i.e., the inability to execute the same amount of claps as performed by the examiner, was originally reported as a sign specific for progressive supranuclear palsy (PSP). Recent research, however, has provided evidence for the occurrence of the applause sign in various conditions. The aim of this study was to determine the prevalence of the applause sign and correlate its presence with neuropsychological and MRI volumetry findings in frontotemporal lobar degeneration and related conditions...
December 1, 2018: Journal of Neurology
Alina Nickel, David Milford, Manuel Fischer, Martin Bendszus, Sabine Heiland
INTRODUCTION: Glioblastoma multiforme is the most frequent innate brain tumor and still yields an unfavorable prognosis of 15 months of survival after diagnosis. Animal models play an important role in the investigation of therapeutic strategies of brain tumors. Thereby, MRI is substantial to individual follow-up examination for therapeutic response. Contrast agent dosage at 1.5 and 3T MRI has been thoroughly tested, while there is hardly any data for 9.4T. Therefore, the aim of this study was to find the optimal contrast agent dosage at 9...
November 20, 2018: Zeitschrift Für Medizinische Physik
G P D Argyropoulos, K E Watkins, E Belton-Pagnamenta, F Liégeois, K S Saleem, M Mishkin, F Vargha-Khadem
Bilateral volume reduction in the caudate nucleus has been established as a prominent brain abnormality associated with a FOXP2 mutation in affected members of the 'KE family', who present with developmental orofacial and verbal dyspraxia in conjunction with pervasive language deficits. Despite the gene's early and prominent expression in the cerebellum and the evidence for reciprocal cerebellum-basal ganglia connectivity, very little is known about cerebellar abnormalities in affected KE members. Using cerebellum-specific voxel-based morphometry (VBM) and volumetry, we provide converging evidence from subsets of affected KE members scanned at three time points for grey matter (GM) volume reduction bilaterally in neocerebellar lobule VIIa Crus I compared with unaffected members and unrelated controls...
November 20, 2018: Cerebellum
Virginia B Planz, Meghan G Lubner, Perry J Pickhardt
Volumetric analysis is an objective 3D assessment of a lesion or organ that may more accurately depict the burden of complex objects compared to traditional linear size measurement. Small changes in linear size are amplified by corresponding changes in volume, which could have significant clinical implications. Though early methods of calculating volumes were time-consuming and laborious, multiple software platforms are now available with varying degrees of user-software interaction ranging from manual to fully automated...
November 20, 2018: British Journal of Radiology
Anthony C Wang, Ashish H Shah, Charif Sidani, Brandon G Gaynor, Simon Dockrell, S Shelby Burks, Zoukaa B Sargi, Roy R Casiano, Jacques J Morcos
Background  Assessment of the extent of resection after surgical resection of pituitary adenomas is most commonly reported in terms of the presence or absence of residual tumor. A quantitative comparison of volumetric resection between endonasal endoscopy (EE) and microsurgery (MS) has rarely been done. Methods  A retrospective analysis was performed on a consecutive series of 154 patients with pituitary adenomas treated by the same surgeon at a single institution. We employed volumetric analysis pre- and postoperatively on two cohorts of pituitary adenoma patients treated through MS ( n  = 37) versus EE approach ( n  = 117)...
December 2018: Journal of Neurological Surgery. Part B, Skull Base
Lorenz Epprecht, Marc Mosimann, Domenic Vital, David Holzmann
Objective  We compare the open and transnasal approaches for the excision of juvenile nasopharyngeal angiofibromas regarding the rate of morbidity, and residual tumor and its symptomatic recurrence over time. In addition, we present volumetric measurements of juvenile nasopharyngeal angiofibromas over time. Methods  All surgically treated patients of our institution were reviewed back to 1969 for type of surgery, residual tumor by magnetic resonance imaging (MRI)-based volumetry, recurrence, and morbidity...
December 2018: Journal of Neurological Surgery. Part B, Skull Base
Joshua Giambattista, Nevin McVicar, Sarah Hamilton, Montgomery Martin, Benjamin Maas, Cheryl Ho, Jonn Wu, Eric Tran, John Hay, Eric Berthelet
Introduction The addition of induction chemotherapy (IC) to the standard concurrent chemoradiotherapy (CCRT) is under consideration in locally advanced nasopharyngeal carcinoma (LANPC). To-date, no studies have reported primary gross tumour volume (GTVp) changes using gemcitabine and cisplatin as the IC phase in LANPC. We investigated the timing and magnitude of GTVp response throughout sequential gemcitabine and cisplatin IC and CCRT for LANPC. Toxicity and tumour control probability (TCP) analyses are also presented Methods Ten patients with LANPC underwent sequential IC and CCRT between 2011 and 2015...
September 13, 2018: Curēus
Jouni K Kuusisto, Vesa M Järvinen, Juha P Sinisalo
BACKGROUND: Left atrial volume is a prognostic factor in cardiac pathologies. We aimed to validate left atrial volume detection with 3D and 2D echocardiography (3DE and 2DE) by human cadaveric casts. 3DE facilitates measurement of atrial volume without geometrical assumptions or dependence on imaging angle in contrast to 2DE methods. METHODS: For method validation, six water-filled balloons were submerged in a 20-l water tank and their volumes were measured with 3DE...
November 15, 2018: BMC Medical Imaging
Cong Zhou, Yuqi Cheng, Liangliang Ping, Jian Xu, Zonglin Shen, Linling Jiang, Li Shi, Shuran Yang, Yi Lu, Xiufeng Xu
Magnetic resonance imaging (MRI) methods have been used to detect cerebral anatomical distinction between obsessive-compulsive disorder (OCD) patients and healthy controls (HC). Machine learning approach allows for the possibility of discriminating patients on the individual level. However, few studies have used this automatic technique based on multiple modalities to identify potential biomarkers of OCD. High-resolution structural MRI and diffusion tensor imaging (DTI) data were acquired from 48 OCD patients and 45 well-matched HC...
2018: Frontiers in Psychiatry
Ebba Beller, Daniel Keeser, Antonia Wehn, Berend Malchow, Temmuz Karali, Andrea Schmitt, Irina Papazova, Boris Papazov, Franziska Schoeppe, Giovanna Negrao de Figueiredo, Birgit Ertl-Wagner, Sophia Stoecklein
PURPOSE: Development of a warp-based automated brain segmentation approach of 3D fluid-attenuated inversion recovery (FLAIR) images and comparison to 3D T1-based segmentation. METHODS: 3D FLAIR and 3D T1-weighted sequences of 30 healthy subjects (mean age 29.9 ± 8.3 years, 8 female) were acquired on the same 3T MR scanner. Warp-based segmentation was applied for volumetry of total gray matter (GM), white matter (WM), and 116 atlas regions. Segmentation results of both sequences were compared using Pearson correlation (r)...
November 6, 2018: Neuroradiology
H Kato, M Usui, A Nakatsuka, A Hayasaki, T Ito, Y Iizawa, Y Murata, A Tanemura, N Kuriyama, Y Azumi, M Kishiwada, S Mizuno, H Sakurai, S Isaji
Isolated biliary leakage is difficult to manage, and afflicted patients often develop refractory fistula. The present case was a 43-year-old male donor whose wife developed acute fulminant liver failure. Computed tomography (CT) volumetry showed that the estimated remnant liver volume was only 394 mL (31%) if his right lobe would be harvested. Since remnant liver volume was marginal, our proposed cut line for the right hepatectomy was set in order to preserve branches of the middle hepatic vein draining segments 4b+8 and 5...
November 2018: Transplantation Proceedings
Kemal Murat Haberal, Feride Kural Rahatlı, Hale Turnaoğlu, Gonca Özgün, Mehmet Coşkun
OBJECTIVES: Computed tomography liver volumetry has been widely used to detect total and segmental liver volume in living-donor liver transplantation. However, use of this technique to evaluate the cirrhotic liver remains unclear. In this study, we evaluated the accuracy of freehand computed tomography volumetry to assess total liver volume by comparing weights of total hepatectomy specimens in patients with cirrhosis. For our analyses, we considered the density of a cirrhotic liver to be 1...
November 6, 2018: Experimental and Clinical Transplantation
Stelmo Magalhaes Barros Netto, Aristofanes Correa Silva, Anselmo Cardoso de Paiva, Rofolfo Acatauassu Nunes, Marcelo Gattass
Lung cancer is the type of cancer that most kills after the beginning diagnostic. To aid the specialist in this diagnostic, the temporal evaluation comes up as a tool to analyze the indeterminate lesions that may be benign or malignant lesions during the treatment. With this intention, it is proposed a methodology for analysis, quantification, and visualization of changes in lung lesions. This methodology used modified quality threshold clustering algorithm to associate each voxel of the lesion to a cluster and the changes in the lesion over time are defined when a voxel changes to another cluster...
October 31, 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Hiroaki Takahashi, Sota Masuoka, Katsuhiro Nasu, Kensaku Mori, Takahiro Kojima, Kuniaki Fukuda, Kazuhiro Takahashi, Toshitaka Ishiguro, Takahiro Hosokawa, Manabu Minami
Background: Sorafenib has been used in the treatment of advanced hepatocellular carcinoma (HCC) and renal cell carcinoma (RCC). Sorafenib-associated organ reduction have been reported on imaging, such as thyroid, pancreas and muscle, but there has been no research on prostate volume reduction (PVR). Methods: We retrospectively analyzed 26 patients (twenty with HCC and six patients with RCC) who underwent sorafenib therapy for 31 to 1225 days (median, 100 days). PVR was estimated by two independent readers using CT volumetry...
October 26, 2018: Journal of the Belgian Society of Radiology
Manoj Gupta, Partha Sarathi Choudhury, Shivendra Singh, Dibyamohan Hazarika
Future remnant liver function (FRL-F) estimation is important before major liver resection to avoid posthepatectomy liver failure (PHLF). Conventionally, it is estimated by global dynamic liver function tests which assume homogeneous liver function and unable to calculate regional function. Computed tomography is another method to estimate FRL volume but assumes that volume is equivalent to function. Hence, a global and regional non-invasive liver function test is desirable. Studies were identified by MEDLINE, PubMed, and Google Scholar for articles from January 1990 to December 2017 using the following keywords "Mebrofenin, hepatobiliary scintigraphy (HBS), FRL-F, PHLF, portal vein embolization (PVE)...
October 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Ulf Karl-Martin Teichgräber, Judith Hackbarth
Objectives: To date, the reliability of ultrasound for the quantitative assessment of pleural effusion has been limited. In the following study, an easy and cost-effective bedside ultrasound method was developed and investigated for specific use in the intensive care unit (ICU). Methods: 22 patients (median age: 58.5 years, range: 37-88 years, 14 men and 8 women) with a total of 31 pleural effusions were examined in the ICU. The inclusion criterion was complete visualization of the effusion on chest computed tomography (CT)...
October 2018: Ultrasound International Open
Nicholas Krasnow, Bradley Pogostin, James Haigney, Brittany Groh, Winston Weiler, Michael Tenner, Marion Kessler, Michael Frey, Richard A Noto
Background Pituitary cysts have been speculated to cause endocrinopathies. We sought to describe the prevalence and volumetry of pituitary cysts in patients with growth hormone deficiency (GHD) and idiopathic short stature (ISS). Methods Six hundred and eighteen children evaluated for growth failure at the Division of Pediatric Endocrinology at New York Medical College between the years 2002 and 2012, who underwent GH stimulation testing and had a brain magnetic resonance imaging (MRI) prior to initiating GH treatment were randomly selected to be a part of this study...
November 27, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Maxim Avanesov, Anastassia Löser, Alla Smagarynska, Sarah Keller, Helena Guerreiro, Enver Tahir, Murat Karul, Gerhard Adam, Jin Yamamura
PURPOSE: The necrosis-fibrosis hypothesis describes a continuum between single attacks of acute pancreatitis (SAP), recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) with endocrine and exocrine pancreatic insufficiency. For prevention purposes we evaluated clinico-radiological parameters and pancreatic volumetry to compare SAP and RAP and provide prognostic relevance on short-term mortality, need for intervention and the hospitalization duration. MATERIALS AND METHODS: We retrospectively investigated 225 consecutive patients (150 males, range 19-97years) with acute pancreatitis (74%SAP, 26%RAP) according to the revised Atlanta classification...
2018: PloS One
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