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https://www.readbyqxmd.com/read/29715129/second-opinion-reviews-for-cancer-diagnoses-in-anatomic-pathology-a-comprehensive-cancer-center-s-experience
#1
Carolina Strosberg, Julie Gibbs, Diana Braswell, Ronni R Leslie, Jane Messina, Barbara A Centeno, Domenico Coppola
AIM: The objective of this study was to define the rates of discrepancy between outside pathological diagnoses and secondary reviews. MATERIALS AND METHODS: We assessed the rates of discordance between outside diagnoses and secondary reviews, categorizing by organ site and minor or major (affecting patient care) discordances. RESULTS: A total of 9,289 consecutive surgical pathology (SP) and cytopathology (CP) cases reviewed in 2015 were identified...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/28987172/acute-and-chronic-viral-infections
#2
REVIEW
Nikolaus Deigendesch, Werner Stenzel
A large number of viruses belonging to various families are able to cause central nervous system (CNS) infections and contribute significantly to burden of disease in humans globally. Most viral CNS infections are benign and self-limiting, and most remain undiagnosed. However, some viruses can cause severe inflammation, leading to morbidity and mortality, and result in severe long-term residual damage and neurologic dysfunction in patients. The potential of viruses to cause CNS inflammation greatly varies depending on host factors, such as age, sex, and genetic background, as well as viral factors...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/26530263/the-role-of-neuropathology-in-the-management-of-patients-with-diffuse-low-grade-glioma-a-systematic-review-and-evidence-based-clinical-practice-guideline
#3
REVIEW
Daniel P Cahill, Andrew E Sloan, Brian V Nahed, Kenneth D Aldape, David N Louis, Timothy C Ryken, Steven N Kalkanis, Jeffrey J Olson
TARGET POPULATION: Adult patients (age ≥18 years) who have suspected low-grade diffuse glioma. QUESTION: What are the optimal neuropathological techniques to diagnose low-grade diffuse glioma in the adult? RECOMMENDATION: LEVEL I: Histopathological analysis of a representative surgical sample of the lesion should be used to provide the diagnosis of low-grade diffuse glioma. LEVEL III: Both frozen section and cytopathologic/smear evaluation should be used to aid the intra-operative assessment of low-grade diffuse glioma diagnosis...
December 2015: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/25776047/a-nationwide-telepathology-consultation-and-quality-control-program-in-china-implementation-and-result-analysis
#4
Je Chen, Yahui Jiao, Chaohui Lu, Jun Zhou, Zongjiu Zhang, Chen Zhou
BACKGROUND: Telepathology may play an important role in pathology consultation and quality control for cancer diagnosis in China, as the country has the largest population of cancer patients worldwide. In 2011, the Pathology Quality Control Center of China and Ministry of Health developed and implemented a nationwide telepathology consultation and quality control program for cancer diagnosis in China. We here report the results of the two-year implementation and experiences. METHODS: the program built an Internet based telepathology platform to connect participating hospitals and expert consultants...
December 2014: Diagnostic Pathology
https://www.readbyqxmd.com/read/25565398/a-nationwide-telepathology-consultation-and-quality-control-program-in-china-implementation-and-result-analysis
#5
Je Chen, Yahui Jiao, Chaohui Lu, Jun Zhou, Zongjiu Zhang, Chen Zhou
BACKGROUND: Telepathology may play an important role in pathology consultation and quality control for cancer diagnosis in China, as the country has the largest population of cancer patients worldwide. In 2011, the Pathology Quality Control Center of China and Ministry of Health developed and implemented a nationwide telepathology consultation and quality control program for cancer diagnosis in China. We here report the results of the two-year implementation and experiences. METHODS: the program built an Internet based telepathology platform to connect participating hospitals and expert consultants...
2014: Diagnostic Pathology
https://www.readbyqxmd.com/read/22985227/the-uems-section-board-of-pathology-chapter-6-requirement-for-recognition-of-postgraduate-training-in-pathology-a-presentation-of-the-paris-document
#6
REVIEW
M Tötsch, C Cuvelier, L Vass, A Fassina
After more than five years discussion the UEMS Section/Board of Pathology agreed a specification of requirements for recognition of post-graduate training in pathology, which is the key to the future of our discipline. The document published here, subject to ratification by UEMS Council, was voted on and accepted by the Pathology Board at the UEMS Paris meeting of 9 June 2012. Cytopathology is regarded as integral part of pathology: in general, training in pathology takes five years and maintains a common trunk of four (minimum three) years where surgical pathology, autopsy pathology and basic knowledge of neuropathology, dermatopathology and cytopathology are adequately trained and assessed...
October 2012: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/22745113/early-antioxidant-treatment-and-delayed-hypothermia-after-hypoxia-ischemia-have-no-additive-neuroprotection-in-newborn-pigs
#7
Xinli Ni, Zeng-Jin Yang, Bing Wang, Erin L Carter, Abby C Larson, Lee J Martin, Raymond C Koehler
BACKGROUND: The implementation and clinical efficacy of hypothermia in neonatal hypoxic-ischemic (HI) encephalopathy are limited, in part, by the delay in instituting hypothermia and access to equipment. In a piglet model of HI, half of the neurons in putamen already showed ischemic cytopathology by 6 hours of recovery. We tested the hypothesis that treatment with the superoxide dismutase-catalase mimetic EUK-134 at 30 minutes of recovery provides additive neuronal protection when combined with 1 day of whole-body hypothermia implemented 4 hours after resuscitation...
September 2012: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/21929559/%C3%AE-synuclein-neuropathology-is-controlled-by-nuclear-hormone-receptors-and-enhanced-by-docosahexaenoic-acid-in-a-mouse-model-for-parkinson-s-disease
#8
Eugenia Yakunin, Virginie Loeb, Haya Kisos, Yoav Biala, Shlomo Yehuda, Yoel Yaari, Dennis J Selkoe, Ronit Sharon
α-Synuclein (α-Syn) is a neuronal protein that accumulates progressively in Parkinson's disease (PD) and related synucleinopathies. Attempting to identify cellular factors that affect α-Syn neuropathology, we previously reported that polyunsaturated fatty acids (PUFAs) promote α-Syn oligomerization and aggregation in cultured cells. We now report that docosahexaenoic acid (DHA), a 22:6 PUFA, affects α-Syn oligomerization by activating retinoic X receptor (RXR) and peroxisome proliferator-activated receptor γ2 (PPARγ2)...
May 2012: Brain Pathology
https://www.readbyqxmd.com/read/21437732/a-peculiar-constellation-of-tau-pathology-defines-a-subset-of-dementia-in-the-elderly
#9
Gabor G Kovacs, Kinga Molnár, Lajos László, Thomas Ströbel, Gergö Botond, Selma Hönigschnabl, Angelika Reiner-Concin, Miklós Palkovits, Peter Fischer, Herbert Budka
Sporadic tauopathies are characterized by differential cellular and topographical predominance of phospho-tau immunoreactivity and biochemical distinction of the tau protein. Established entities include progressive supranuclear palsy, corticobasal degeneration, Pick's disease, and argyrophilic grain disease. During a community-based longitudinal study on aging, we detected tau pathologies not compatible with these categories. We immunostained for different phospho-tau epitopes, 4R and 3R tau isoforms, α-synuclein, amyloid-β, and phospho-TDP-43, analyzed the MAPT and ApoE genes, and performed western blotting for the tau protein...
August 2011: Acta Neuropathologica
https://www.readbyqxmd.com/read/19806442/amino-acids-variations-in-amyloid-beta-peptides-mitochondrial-dysfunction-and-new-therapies-for-alzheimer-s-disease
#10
REVIEW
Hani Atamna
Soluble oligomers and/or aggregates of Amyloid-beta (Abeta) are viewed by many as the principal cause for neurodegeneration in Alzheimer's disease (AD). However, the mechanism by which Abeta and its aggregates cause neurodegeneration is not clear. The toxicity of Abeta has been attributed to its hydrophobicity. However, many specific mitochondrial cytopathologies e.g., loss of complex IV, loss of iron homeostasis, or oxidative damage cannot be explained by Abeta's hydrophobicity. In order to understand the role of Abeta in these cytopathologies we hypothesized that Abeta impairs specific metabolic pathways...
October 2009: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/18971262/the-p14-fast-protein-of-reptilian-reovirus-increases-vesicular-stomatitis-virus-neuropathogenesis
#11
Christopher W Brown, Kyle B Stephenson, Stephen Hanson, Michael Kucharczyk, Roy Duncan, John C Bell, Brian D Lichty
The fusogenic orthoreoviruses express nonstructural fusion-associated small transmembrane (FAST) proteins that induce cell-cell fusion and syncytium formation. It has been speculated that the FAST proteins may serve as virulence factors by promoting virus dissemination and increased or altered cytopathology. To directly test this hypothesis, the gene encoding the p14 FAST protein of reptilian reovirus was inserted into the genome of a heterologous virus that does not naturally form syncytia, vesicular stomatitis virus (VSV)...
January 2009: Journal of Virology
https://www.readbyqxmd.com/read/17522439/signal-transduction-cascades-associated-with-oxidative-stress-in-alzheimer-s-disease
#12
REVIEW
Robert B Petersen, Akihiko Nunomura, Hyoung-gon Lee, Gemma Casadesus, George Perry, Mark A Smith, Xiongwei Zhu
It has now been established through multiple lines of evidence that oxidative stress is an early event in Alzheimer's disease, occurring prior to the canonical cytopathology. Thus, oxidative stress likely plays a key pathogenic role in the disease and is clearly involved in the cell loss and other neuropathology associated with Alzheimer's disease as demonstrated by the large number of metabolic signs of oxidative stress and by markers of oxidative damage. One puzzling observation, however, is that oxidative damage decreases with disease progression, such that levels of markers of rapidly formed oxidative damage, which are initially elevated, decrease as the disease progresses to advanced Alzheimer's disease...
May 2007: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/17060579/clinicopathologic-investigation-of-a-family-with-expanded-sca8-cta-ctg-repeats
#13
H Ito, H Kawakami, R Wate, S Matsumoto, T Imai, A Hirano, H Kusaka
We investigated a family manifesting progressive ataxia, with expanded SCA8 CTA/CTG repeats. Neuropathologically, degeneration of Purkinje, inferior olivary, and nigral neurons and periaqueductal gliosis were evident. The sites of Purkinje cell loss were occupied by fibrillary accumulations. The remaining Purkinje cells showed somatic sprouts, and intracytoplasmic 1C2-positive granular structures were recognizable. This characteristic distribution of neurodegeneration and Purkinje cell cytopathology were distinct from those of other hereditary spinocerebellar ataxias previously reported...
October 24, 2006: Neurology
https://www.readbyqxmd.com/read/17011168/irradiation-exacerbates-cortical-cytopathology-in-the-eker-rat-model-of-tuberous-sclerosis-complex-but-does-not-induce-hyperexcitability
#14
Naranzogt Tschuluun, H Jürgen Wenzel, Philip A Schwartzkroin
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by multi-organ pathologies. Most TSC patients exhibit seizures, usually starting in early childhood. The neuropathological hallmarks of the disease - cortical tubers, containing cytopathological neuronal and glial cell types - appear to be the source of seizure initiation. However, the contribution of these aberrant cell populations to TSC-associated epilepsies is not fully understood. To gain further insight, investigators have attempted to generate animal models with TSC-like brain abnormalities...
January 2007: Epilepsy Research
https://www.readbyqxmd.com/read/16763857/cortical-dysplasia-neuropathological-aspects
#15
REVIEW
Christian H Rickert
INTRODUCTION: Malformations of the cerebral cortex are a frequent cause of pharmacoresistant epilepsies and developmental disorders. EPIDEMIOLOGY AND GENETICS: The incidence of cortical dysplasias in epilepsy surgical series varies from 12 to 40% and focal cortical dysplasias (FCD) are one of the most common neuropathological findings in resection specimens from pediatric patients undergoing cortical resections for the treatment of refractory epilepsy. MACROSCOPY AND HISTOPATHOLOGY: Surgical specimens in FCD may appear normal macroscopically, but in some cases, widening of the cortex with poor demarcation from the underlying white matter is noted...
August 2006: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/16574280/locus-coeruleus-neurofibrillary-degeneration-in-aging-mild-cognitive-impairment-and-early-alzheimer-s-disease
#16
Aneta Grudzien, Pamela Shaw, Sandra Weintraub, Eileen Bigio, Deborah C Mash, M Marsel Mesulam
Neurofibrillary degeneration in the nucleus basalis and a loss of its cortical cholinergic projections are prominent components of the neuropathology in Alzheimer's disease (AD). The AD brain is also associated with a degeneration of the noradrenergic projections arising from the nucleus locus coeruleus (LC), but the time course of this lesion is poorly understood. To determine whether the LC displays neurofibrillary abnormalities early in the course of events leading to AD, we examined tissue specimens from seven cognitively normal controls and five subjects at the stages of mild cognitively impairment (MCI) or early AD...
March 2007: Neurobiology of Aging
https://www.readbyqxmd.com/read/15896347/cell-line-dependent-rna-expression-profiles-of-prion-infected-mouse-neuronal-cells
#17
Alex D Greenwood, Marion Horsch, Anna Stengel, Ina Vorberg, Gloria Lutzny, Elke Maas, Sandra Schädler, Volker Erfle, Johannes Beckers, Hermann Schätzl, Christine Leib-Mösch
The overall impact of prion disease on gene expression is not well characterized. We have carried out a large-scale expression analysis of specific cell types commonly employed in studies of prion disease. Neuroblastoma cells (N2a) and hypothalamic neuronal cells (GT1) can be persistently infected with mouse-adapted scrapie prions, the latter demonstrating cytopathologic effects associated with prion neuropathology. Exploiting a mouse DNA microarray containing approximately 21,000 spotted cDNAs, we have identified several hundred differentially expressed sequences in the two cell lines when infected with prion strain RML...
June 10, 2005: Journal of Molecular Biology
https://www.readbyqxmd.com/read/15581421/the-neuronal-cytoskeleton-as-a-potential-therapeutical-target-in-neurodegenerative-diseases-and-schizophrenia
#18
REVIEW
G Benitez-King, G Ramírez-Rodríguez, L Ortíz, I Meza
The cytoskeleton plays a key role in maintaining the highly asymmetrical shape and structural polarity of neurons that are essential for neuronal physiology. Cytoskeletal reorganization plays a key role in neuritogenesis. In neurodegenerative diseases, the cytoskeleton is abnormally assembled and impairment of neurotransmission occurs. In Alzheimer's disease, abundant amyloid plaques and neurofibrillary tangles constitute the two major neuropathologic alterations present in the brain. Neurofibrillary tangles are formed of paired helical filaments consisting nearly entirely of the microtubule-associated protein tau...
December 2004: Current Drug Targets. CNS and Neurological Disorders
https://www.readbyqxmd.com/read/15053949/oxidative-stress-signalling-in-alzheimer-s-disease
#19
REVIEW
Xiongwei Zhu, Arun K Raina, Hyoung-Gon Lee, Gemma Casadesus, Mark A Smith, George Perry
Multiple lines of evidence demonstrate that oxidative stress is an early event in Alzheimer's disease (AD), occurring prior to cytopathology, and therefore may play a key pathogenic role in the disease. Indeed, that oxidative mechanisms are involved in the cell loss and other neuropathology associated with AD is evidenced by the large number of metabolic signs of oxidative stress as well as by markers of oxidative damage. However, what is intriguing is that oxidative damage decreases with disease progression, such that levels of markers of rapidly formed oxidative damage, which are initially elevated, decrease as the disease progresses to advanced AD...
March 12, 2004: Brain Research
https://www.readbyqxmd.com/read/14656074/the-cellular-and-molecular-pathology-of-the-motor-system-in-hereditary-spastic-paraparesis-due-to-mutation-of-the-spastin-gene
#20
COMPARATIVE STUDY
Stephen B Wharton, Christopher J McDermott, Andrew J Grierson, Jonathan D Wood, Catherine Gelsthorpe, Paul G Ince, Pamela J Shaw
Hereditary spastic paraparesis (HSP) is a genetically heterogeneous disorder, the most common cause of which is mutation of the spastin gene. Recent evidence suggests a role for spastin in microtubule dynamics, but the distribution of the protein within the CNS is unknown. The core neuropathology of HSP is distal degeneration of the lateral corticospinal tract and of fasciculus gracilis, but there are few neuropathological studies of cases with a defined mutation. We aimed to determine the distribution of spastin expression in the human CNS and to investigate the cellular pathology of the motor system in HSP due to mutation of the spastin gene...
November 2003: Journal of Neuropathology and Experimental Neurology
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