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https://www.readbyqxmd.com/read/30515221/the-effects-of-platelet-derived-growth-factor-bb-on-bone-marrow-stromal-cell-mediated-vascularized-bone-regeneration
#1
Maolin Zhang, Wenwen Yu, Kunimichi Niibe, Wenjie Zhang, Hiroshi Egusa, Tingting Tang, Xinquan Jiang
Regenerative medicine for bone tissue mainly depends on efficient recruitment of endogenous or transplanted stem cells to guide bone regeneration. Platelet-derived growth factor (PDGF) is a functional factor that has been widely used in tissue regeneration and repair. However, the short half-life of PDGF limits its efficacy, and the mechanism by which PDGF regulates stem cell-based bone regeneration still needs to be elucidated. In this study, we established genetically modified PDGF-B-overexpressing bone marrow stromal cells (BMSCs) using a lentiviral vector and then explored the mechanism by which PDGF-BB regulates BMSC-based vascularized bone regeneration...
2018: Stem Cells International
https://www.readbyqxmd.com/read/30514957/biomaterial-guided-delivery-of-gene-vectors-for-targeted-articular-cartilage-repair
#2
REVIEW
Magali Cucchiarini, Henning Madry
Articular cartilage defects are prevalent and are potentially involved in the initiation of osteoarthritis, yet the lack of efficient therapeutic options to treat cartilage defects represents a substantial challenge. Molecular treatments that require the delivery of therapeutic gene vectors are often less effective that specific, targeted approaches, and the scientific evidence for acellular biomaterial-assisted procedures is limited. Controlled delivery of gene vectors using biocompatible materials is emerging as a novel strategy for the sustained and tuneable release of gene therapies in a spatiotemporally precise manner, thereby reducing intra-articular vector spread and possible loss of the therapeutic gene product...
December 4, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30514442/the-effect-of-membrane-coverage-on-the-resorption-of-autogenous-intraoral-block-grafts-in-horizontal-ridge-augmentation-a-systematic-review-of-literature-and-meta-analysis-inevitability-or-an-iatrogenic-vulnerability
#3
REVIEW
John Zaki, Marwa Alnawawy, Nermin Yussif, Ahmed Elkhadem
BACKGROUND: Autogenous intraoral block grafting is the gold standard augmentation technique for moderate-to-severe horizontal ridge deficiency. However, the graft undergoes variable resorption during healing that might jeopardize the outcome of the procedure. Several studies hypothesized that covering the graft with a membrane decreases the amount of graft resorption, but this effect is not established in the literature. OBJECTIVE: The objective of this study is to assess the clinical value of covering intraoral block grafts with membranes in horizontal ridge augmentation regarding graft resorption (primary outcome), graft success, net bone gain, and complications (secondary outcomes)...
December 2018: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/30513940/reconstructing-bone-with-natural-bone-graft-a-review-of-in-vivo-studies-in-bone-defect-animal-model
#4
REVIEW
Mengying Liu, Yonggang Lv
Bone defects caused by fracture, disease or congenital defect remains a medically important problem to be solved. Bone tissue engineering (BTE) is a promising approach by providing scaffolds to guide and support the treatment of bone defects. However, the autologous bone graft has many defects such as limited sources and long surgical procedures. Therefore, xenograft bone graft is considered as one of the best substitutions and has been effectively used in clinical practice. Due to better preserved natural bone structure, suitable mechanical properties, low immunogenicity, good osteoinductivity and osteoconductivity in natural bone graft, decellularized and demineralized bone matrix (DBM) scaffolds were selected and discussed in the present review...
December 3, 2018: Nanomaterials
https://www.readbyqxmd.com/read/30509121/fabrication-in-vitro-and-in-vivo-studies-of-bilayer-composite-membrane-for-periodontal-guided-tissue-regeneration
#5
Saba Zahid, Abdul Samad Khan, Aqif Anwar Chaudhry, Sarah Ghafoor, Qurat Ul Ain, Ahtasham Raza, Muhammad Imran Rahim, Oliver Goerke, Ihtesham Ur Rehman, Asma Tufail
Development of a guided occlusive biodegradable membrane with controlled morphology in order to restrict the ingrowth of epithelial cells is still a challenge in dental tissue engineering. A bilayer membrane with a non-porous upper layer (polyurethane) and porous lower layer (polycaprolactone and bioactive glass composite) with thermoelastic properties to sustain surgery treatment was developed by lyophilization. Morphology, porosity, and layers attachment were controlled by using the multi-solvent system. In vitro and in vivo biocompatibility, cell attachment, and cell proliferation were analyzed by immunohistochemistry and histology...
December 3, 2018: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/30508512/steered-migration-and-changed-morphology-of-human-astrocytes-by-an-applied-electric-field
#6
Chun Yang, Lei Wang, Weiji Weng, Shen Wang, Yuxiao Ma, Qing Mao, Guoyi Gao, Rui Chen, Junfeng Feng
Direct current electric field (DC EF) plays a role in influencing the biological behaviors and functions of cells. We hypothesize that human astrocytes (HAs) could also be influenced in EF. Astrocytes, an important type of nerve cells with a high proportion quantitatively, are generally activated and largely decide the brain repair results after brain injury. So far, no electrotaxis study on HAs has been performed. We here obtained HAs derived from brain trauma patients. After purification and identification, HAs were seeded in the EF chamber and recorded in a time-lapse image system...
November 30, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/30505446/cell-secreted-extracellular-matrix-independent-of-cell-source-promotes-the-osteogenic-differentiation-of-human-stromal-vascular-fraction
#7
Jenna N Harvestine, Hakan Orbay, Jonathan Y Chen, David E Sahar, J Kent Leach
Lipoaspirates contain a readily accessible heterogeneous cell source for use in bone regeneration collectively referred to as the stromal vascular fraction (SVF). However, the osteogenic potential of SVF is inferior to other progenitor cell populations, thereby requiring alternative strategies to potentiate its effective use in cell-based therapies of bone repair. Cell-secreted extracellular matrix (ECM) is a promising substrate to guide cell phenotype or for use in biomaterial design, yet the instructional capacity of ECMs produced by various cell types is unknown...
June 28, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/30505425/large-adipose-tissue-generation-in-a-mussel-inspired-bioreactor-of-elastic-mimetic-cryogel-and-platelets
#8
Qiang Chang, Junrong Cai, Ying Wang, Ruijia Yang, Malcolm Xing, Feng Lu
Soft tissue generation, especially in large tissue, is a major challenge in reconstructive surgery to treat congenital deformities, posttraumatic repair, and cancer rehabilitation. The concern is along with the donor site morbidity, donor tissue shortage, and flap necrosis. Here, we report a dissection-free adipose tissue chamber-based novel guided adipose tissue regeneration strategy in a bioreactor of elastic gelatin cryogel and polydopamine-assisted platelet immobilization intended to improve angiogenesis and generate large adipose tissue in situ...
January 2018: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/30505176/biomolecular-phases-in-transverse-palatal-distraction-a-review
#9
REVIEW
Ibrahim Alshahrani
Transverse palatal distraction is a biological process of regenerating new bone and enveloping soft tissues in the maxillary palate region. This technique is similar to Osteo-distraction (OD) procedure for bone lengthening in which gradual and controlled traction forces are applied on the osteotomy gaps to produce new bone in between the surgically separated bone segments. This review describes the different phases after osteotomy and the biological process involved during the new bone and soft tissue formation...
November 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/30504694/effect-of-doxycycline-doped-bone-substitute-on-vertical-bone-augmentation-on-rat-calvaria
#10
Peng Zhang, Lin Ding, Shohei Kasugai
Bio-Oss (BO), one of the bone substitutes, is extensively used for augmentation in dental field because it is highly biocompatible and osteoconductive, which however does not stimulate bone formation. Doxycycline (DOX), a widely-used antibiotic, shows inhibitory effects on inflammation and osteoclastogenesis, and it has been reported to stimulate bone formation. The objective of this study is to investigate the vertical bone formation with DOX doped BO in guided bone regeneration on rat calvaria. Forty rats underwent calvarial vertical augmentation surgeries...
December 1, 2018: Dental Materials Journal
https://www.readbyqxmd.com/read/30484284/autologous-platelet-concentrates-for-treating-periodontal-infrabony-defects
#11
REVIEW
Massimo Del Fabbro, Lorena Karanxha, Saurav Panda, Cristina Bucchi, Jayakumar Nadathur Doraiswamy, Malaiappan Sankari, Surendar Ramamoorthi, Sheeja Varghese, Silvio Taschieri
BACKGROUND: Periodontal disease is a condition affecting tooth-supporting tissues (gingiva, alveolar bone, periodontal ligament, and cementum), with the potential of introducing severe adverse effects on oral health. It has a complex pathogenesis which involves the combination of specific micro-organisms and a predisposing host response. Infrabony defects are one of the morphological types of alveolar bone defects that can be observed during periodontitis. Recent approaches for the treatment of infrabony defects, combine advanced surgical techniques with platelet-derived growth factors...
November 26, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30482651/apical-u-shape-splitting-technique-for-undercut-areas-of-the-anterior-alveolar-ridge-a-prospective-non-randomized-controlled-study
#12
Q Wu, B Yang, S Gao, P Gong, L Xiang, Y Man, Y Qu
The aim of this study was to investigate a novel apical U-shape splitting technique for horizontal bone augmentation in undercut areas and to compare its efficacy with that of guided bone regeneration (GBR). This was a prospective non-randomized controlled clinical trial. A total of 36 patients, who presented with a labial undercut that was not able to house a normally inclined implant, underwent the new technique or GBR. Radiographic and clinical data were obtained preoperatively, immediately after surgery, and 12 months after surgery...
October 25, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/30479933/injectable-and-spatially-patterned-microporous-annealed-particle-map-hydrogels-for-tissue-repair-applications
#13
Nicole J Darling, Elias Sideris, Naomi Hamada, S Thomas Carmichael, Tatiana Segura
Spatially patterned hydrogels are becoming increasingly popular in the field of regenerative medicine and tissue repair because of their ability to guide cell infiltration and migration. However, postfabrication technologies are usually required to spatially pattern a hydrogel, making these hydrogels difficult to translate into the clinic. Here, an injectable spatially patterned hydrogel is reported using hyaluronic acid (HA)-based particle hydrogels. These particle hydrogels are sequentially loaded into a syringe to form a pattern and, once injected, they maintain the pattern...
November 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/30471474/in-vitro-and-in-vivo-studies-of-electroactive-reduced-graphene-oxide-modified-nanofiber-scaffolds-for-peripheral-nerve-regeneration
#14
Juan Wang, Yuan Cheng, Liang Chen, Tonghe Zhu, Kaiqiang Ye, Chao Jia, Hongjun Wang, Meifang Zhu, Cunyi Fan, Xiumei Mo
Graphene, as a promising biomaterial, has received great attention in biomedical fields due to its intriguing properties, especially the conductivity and biocompatibility. Given limited studies on the effects of graphene-based scaffolds on peripheral nerve regeneration in vitro and in vivo under electrical stimulation (ES), the present study was intended to systematically investigate how conductive graphene-based nanofibrous scaffolds regulate Schwann cell (SC) behavior including migration, proliferation and myelination, and PC12 cell differentiation in vitro via ES, and whether these conductive scaffolds could guide SC migration and promote nerve regeneration in vivo...
November 22, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30469378/scaffold-structural-microenvironmental-cues-to-guide-tissue-regeneration-in-bone-tissue-applications
#15
REVIEW
Xuening Chen, Hongyuan Fan, Xiaowei Deng, Lina Wu, Tao Yi, Linxia Gu, Changchun Zhou, Yujiang Fan, Xingdong Zhang
In the process of bone regeneration, new bone formation is largely affected by physico-chemical cues in the surrounding microenvironment. Tissue cells reside in a complex scaffold physiological microenvironment. The scaffold should provide certain circumstance full of structural cues to enhance multipotent mesenchymal stem cell (MSC) differentiation, osteoblast growth, extracellular matrix (ECM) deposition, and subsequent new bone formation. This article reviewed advances in fabrication technology that enable the creation of biomaterials with well-defined pore structure and surface topography, which can be sensed by host tissue cells (esp...
November 21, 2018: Nanomaterials
https://www.readbyqxmd.com/read/30468436/heterogeneous-chemistry-in-the-3-d-state-an-original-approach-to-generate-bioactive-mechanically-competent-bone-scaffolds
#16
Anna Tampieri, Andrea Ruffini, Alberto Ballardini, Monica Montesi, Silvia Panseri, Francesca Salamanna, Milena Fini, Simone Sprio
The present work investigates heterogeneous gas-solid reactions involved in the biomorphic transformation of natural wood into large 3-D hydroxyapatite (HA) scaffolds recapitulating physico-chemical, morphological and mechanical features typical of natural bone. In particular, we found that the use of a reactive CO2/H2O gas mixture, under supercritical conditions at high pressure, permits to control heterogeneous CaO-CO2 reactions throughout the whole bulk and to direct the nucleation-growth of CaCO3 at a relatively low temperature, thus obtaining a highly reactive 3-D precursor enabling the formation of a large biomorphic HA scaffold preserving fine nanostructure by a hydrothermal process...
November 23, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/30466196/a-bioactive-collagen-membrane-that-enhances-bone-regeneration
#17
Behnoush Khorsand, Satheesh Elangovan, Liu Hong, Michael S D Kormann, Aliasger K Salem
Membranes are an integral component of guided bone regeneration protocols. This pre-clinical study was aimed at enhancing the bioactivity of collagen membranes by incorporating plasmid DNA (pDNA) or chemically modified RNA (cmRNA) encoding bone morphogenetic protein-9 (BMP-9). In addition, we also endeavored to harness the regenerative potential of the periosteum by creating perforations in the membrane. Nanoplexes of polyethylenimine (PEI)-nucleic acids (PEI-pDNA or PEI-cmRNA encoding BMP-9) were incorporated into commercially obtained and perforated collagen membranes (PCM) to produce PCM-pDNA(BMP-9) or PCM-cmRNA(BMP-9)...
November 22, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30464466/small-molecules-modified-biomimetic-gelatin-hydroxyapatite-nanofibers-constructing-an-ideal-osteogenic-microenvironment-with-significantly-enhanced-cranial-bone-formation
#18
Daowei Li, Kai Zhang, Ce Shi, Lijun Liu, Guangxing Yan, Cangwei Liu, Yijun Zhou, Yue Hu, Hongchen Sun, Bai Yang
Background: Repair of nonunion critical-sized bone defects is a significant clinical challenge all over the world. Construction of osteogenic microenvironment that provides osteoconductive and osteoinductive signals is a leading strategy. Materials and methods: In the present study, ascorbic acid (AA) and β-glycerophosphate disodium salt hydrate (β-GP) modified biomimetic gelatin/hydroxyapatite (GH) nanofibrous scaffolds were developed by electrospinning. Then the scaffolds were crosslinked by N-hydroxysulfo-succinimide sodium salt (NHS) and 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC)...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30458111/ferrous-supply-regeneration-nanoengineering-for-cancer-cell-specific-ferroptosis-in-combination-with-imaging-guided-photodynamic-therapy
#19
Tao Liu, Wenlong Liu, Mingkang Zhang, Wuyang Yu, Fan Gao, Chuxin Li, Shi-Bo Wang, Jun Feng, Xian-Zheng Zhang
Non-apoptotic ferroptosis is of clinical importance because it offers a solution to the inevitable biocarriers of traditional apoptotic therapeutic means. Inspired by industrial electro-Fenton technology featured with electrochemical iron cycling, we construct ferrous-supply-regeneration nanoengineering to intervene tumorous iron metabolism for enhanced ferroptosis. Fe3+ ion and naturally derived tannic acid (TA) spontaneously form a network-like corona onto sorafenib (SRF) nanocores. The formed SRF@FeIII TA nanoparticles can respond to a lysosomal acid environment with corona dissociation, permitting SRF release to inhibit GPX4 enzyme for ferroptosis initiation...
November 26, 2018: ACS Nano
https://www.readbyqxmd.com/read/30445700/a-graded-multifunctional-hybrid-scaffold-with-superparamagnetic-ability-for-periodontal-regeneration
#20
Simone Sprio, Elisabetta Campodoni, Monica Sandri, Lorenzo Preti, Tobias Keppler, Frank A Müller, Nicola M Pugno, Anna Tampieri
The regeneration of dental tissues is a still an unmet clinical need; in fact, no therapies have been completely successful in regenerating dental tissue complexes such as periodontium, which is also due to the lack of scaffolds that are able to guide and direct cell fate towards the reconstruction of different mineralized and non-mineralized dental tissues. In this respect, the present work develops a novel multifunctional hybrid scaffold recapitulating the different features of alveolar bone, periodontal ligament, and cementum by integrating the biomineralization process, and tape casting and electrospinning techniques...
November 15, 2018: International Journal of Molecular Sciences
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