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Guided regeneration

Javier Navarro, Jay Swayambunathan, Max Lerman, Marco Santoro, John P Fisher
The layers in skin determine its protective and hemostasis functions. This layered microstructure cannot be naturally regenerated after severe burns; we aim to reconstruct it using guided tissue regeneration (GTR). In GTR, a membrane is used to regulate tissue growth by stopping fast-proliferating cells and allowing slower cells to migrate and reconstruct specialized microstructures. Here, we proposed the use of keratin membranes crosslinked via dityrosine bonding. Variables from the crosslinking process were grouped within an energy density (ED) parameter to manufacture and evaluate the membranes...
October 17, 2018: Acta Biomaterialia
Pauline Marie Chichiricco, Raphael Riva, Jean-Michel Thomassin, Julie Lesoeur, Xavier Struillou, Catherine Le Visage, Christine Jérôme, Pierre Weiss
OBJECTIVE: Periodontitis is an inflammatory disease that destroys the tooth-supporting attachment apparatus. Guided tissue regeneration (GTR) is a technique based on a barrier membrane designed to prevent wound space colonization by gingival cells. This study examined a new formulation composed of two polymers that could be photochemically cross-linked in situ into an interpenetrated polymer network (IPN) forming a hydrogel membrane. METHODS: We synthetized and characterized silanized hydroxypropyl methylcellulose (Si-HPMC) for its cell barrier properties and methacrylated carboxymethyl chitosan (MA-CMCS) for its degradable backbone to use in IPN...
October 15, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
Carlos L Muñoz Brenes, Kelly W Jones, Peter Schlesinger, Juan Robalino, Lee Vierling
Protected areas (PAs) are a prominent approach to maintaining and enhancing biodiversity and ecosystem services. A critical question for safeguarding these resources is how PA governance processes and management structures influence their effectiveness. We conduct an impact evaluation of 12 PAs in three Central American countries to assess how processes in management restrictions, management capacity, and decentralization affect the annual change in the satellite-derived Normalized Difference Vegetation Index (NDVI)...
2018: PloS One
Bartłomiej Górski, Tomasz Kaczyński, Andrzej Miskiewicz, Renata Górska
BACKGROUND: In order to regenerate periodontal tissues, necessary conditions for this process must be created during surgery, primarily by allowing uninfected adhesion of the clot to the root surface, and then its stable position in the defect. OBJECTIVES: The aim of this secondary analysis was to evaluate early postoperative healing of papillary incisions and its correlations with patient-, siteand technique-related factors following guided tissue regeneration (GTR) in treatment of intrabony defects in patients with aggressive periodontitis (AgP)...
July 2018: Dental and medical problems
Jing Han, Baojin Ma, Hongrui Liu, Ting Wang, Fang Wang, Chengjia Xie, Minqi Li, Hong Liu, Shaohua Ge
Periodontitis is an inflammatory disease leading to tooth loss, alveolar bone absorption and disorder of masticatory function. Guided tissue regeneration (GTR) is one of the most common strategies for regeneration of lost periodontium. During surgical process, barrier membranes, and osteoinductive/osteoconductive materials should be placed, respectively, which may increase risks of infection, bleeding, and difficulty of operation. Here, we introduced a new kind of hydroxyapatite (HAp) nanowires modified polylactic acid (PLA) membrane to achieve barrier/osteoinduction dual functions...
October 16, 2018: Journal of Biomedical Materials Research. Part A
Dong Li, Xiao-Ying Zou, Ikbale El-Ayachi, Luis O Romero, Zongdong Yu, Alejandro Iglesias-Linares, Julio F Cordero-Morales, George T-J Huang
The potential of human mesenchymal stromal/stem cells (MSCs) including oral stem cells (OSCs) as a cell source to derive functional neurons has been inconclusive. Here we tested a number of human OSCs for their neurogenic potential compared to non-OSCs and employed various neurogenic induction methods. OSCs including dental pulp stem cells (DPSCs), gingiva-derived mesenchymal stem cells (GMSCs), stem cells from apical papilla and non-OSCs including bone marrow MSCs (BMMSCs), foreskin fibroblasts and dermal fibroblasts using non-neurosphere-mediated or neurosphere-mediated methods to guide them toward neuronal lineages...
October 15, 2018: Stem Cell Reviews
Hatice O Ozguldez, Junghwa Cha, Yoonmi Hong, Ilkyoo Koh, Pilnam Kim
Background: Human mesenchymal stem cells (hMSCs) are, due to their pluripotency, useful sources of cells for stem cell therapy and tissue regeneration. The phenotypes of hMSCs are strongly influenced by their microenvironment, in particular the extracellular matrix (ECM), the composition and structure of which are important in regulating stem cell fate. In reciprocal manner, the properties of ECM are remodeled by the hMSCs, but the mechanism involved in ECM remodeling by hMSCs under topographical stimulus is unclear...
2018: Biomaterials Research
Megan A Yamoah, Maryam Moshref, Janhavi Sharma, Wei Chun Chen, Hannah A Ledford, Jeong Han Lee, Karen S Chavez, Wenying Wang, Javier E López, Deborah K Lieu, Padmini Sirish, Xiao-Dong Zhang
Purpose: The delivery of transgenes into human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (hiPSC-CMs) represents an important tool in cardiac regeneration with potential for clinical applications. Gene transfection is more difficult, however, for hiPSCs and hiPSC-CMs than for somatic cells. Despite improvements in transfection and transduction, the efficiency, cytotoxicity, safety, and cost of these methods remain unsatisfactory. The objective of this study is to examine gene transfection in hiPSCs and hiPSC-CMs using magnetic nanoparticles (NPs)...
2018: International Journal of Nanomedicine
Alberto Sensini, Luca Cristofolini
Tendon and ligament tissue regeneration and replacement are complex since scaffolds need to guarantee an adequate hierarchical structured morphology, and non-linear mechanical properties. Moreover, to guide the cells' proliferation and tissue re-growth, scaffolds must provide a fibrous texture mimicking the typical of the arrangement of the collagen in the extracellular matrix of these tissues. Among the different techniques to produce scaffolds, electrospinning is one of the most promising, thanks to its ability to produce fibers of nanometric size...
October 12, 2018: Materials
Deepak Bushan Raina, Irfan Qayoom, David Larsson, Ming Hao Zheng, Ashok Kumar, Hanna Isaksson, Lars Lidgren, Magnus Tägil
A metaphyseal bone defect due to infection, tumor or fracture leads to loss of cancellous and cortical bone. An animal model separating the cancellous and cortical healing was used with a combination of a macroporous gelatin-calcium sulphate-hydroxyapatite (Gel-CaS-HA) biomaterial as a cancellous defect filler, and a thin collagen membrane (CM) guiding cortical bone regeneration. The membrane was immobilized with bone morphogenic protein-2 (rhBMP-2) to enhance the osteoinductive properties. The Gel-CaS-HA cancellous defect filler contained both rhBMP-2 and a bisphosphonate, (zoledronate = ZA) to prevent premature callus resorption induced by the pro-osteoclast effect of rhBMP-2 alone...
October 4, 2018: Biomaterials
Melanie J Gupte, W Benton Swanson, Jiang Hu, Xiaobing Jin, Haiyun Ma, Zhanpeng Zhang, Zhongning Liu, Kai Feng, Ganjun Feng, Guiyong Xiao, Nan Hatch, Yuji Mishina, Peter X Ma
In the U.S., 30% of adults suffer joint pain, most commonly in the knee, which severely limits mobility and is often attributed to injury of cartilage and underlying bone in the joint. Current treatment methods such as microfracture result in less resilient fibrocartilage with eventual failure; autografting can cause donor site morbidity and poor integration. To overcome drawbacks in treatment, tissue engineers can design cell-instructive biomimetic scaffolds using biocompatible materials as alternate therapies for osteochondral defects...
October 12, 2018: Acta Biomaterialia
Renjie Liu, Caglar Remzi Becer, Hazel R C Screen
The creation of biomaterials with aligned fibers offers broad applications in tissue regeneration, guiding cell organization and physiological cues, and providing appropriate mechanical properties for many biomedical applications. Herein, for the first time, highly aligned electrospun membranes are designed and developed using glycopolymers. The membranes retain the strong mechanical properties of polycaprolactone, and fiber alignment facilitates the creation of anisotropic mechanical properties, enabling failure stress to be manipulated by an order of magnitude relative to randomly ordered fibers...
October 15, 2018: Macromolecular Bioscience
Miji Yeo, Geun Hyung Kim
For muscle regeneration, a uniaxially arranged micropattern is important to mimic the structure of the natural extracellular matrix. Recently, cell electrospinning (CE) has been tested to fabricate cell-laden fibrous structures by embedding cells directly into micro/nanofibers. Although homogenous cell distribution and a reasonable cell viability of the cell-laden fibrous structure fabricated using the CE process are achieved, unique topographical cues formed by an aligned fibrous structure have not been applied...
October 11, 2018: Small
Amir Reza Rokn, Abbas Monzavi, Mehrdad Panjnoush, Hamid Mahmood Hashemi, Mohammad Javad Kharazifard, Tahereh Bitaraf
BACKGROUND: Short implants have been proposed as an alternative for the rehabilitation of atrophic edentulous areas. PURPOSE: To evaluate the efficacy of 4-mm implants vs longer implants in the atrophic posterior mandibles. MATERIALS AND METHODS: Eleven patients with bilateral atrophic mandibles were rehabilitated with two to four 4-mm implants and 10 or 8-mm long implants in augmented bone using Guided Bone Regeneration procedure. One side of the mandibles was randomly allocated to vertical augmentation with mixed autogenous bone and allograft...
October 11, 2018: Clinical Implant Dentistry and related Research
Joseph H Feinberg, Priyesh Mehta, Lawrence V Gulotta, Answorth A Allen, David W Altchek, Frank A Cordasco, Hollis G Potter, Russell F Warren, Thomas L Wickiewicz, Scott W Wolfe
INTRODUCTION: The purpose was to investigate if surgical arthroscopic decompression or ultrasound-guided aspiration of a paralabral cyst would result in suprascapular nerve recovery from axonal regeneration based on electrodiagnostic testing. METHODS: Nine patients with pre-operative electromyography evidence of suprascapular neuropathy due to paralabral cysts at the suprascapular or spinoglenoid notch were prospectively studied. Eight patients underwent arthroscopic surgical decompression, and one patient underwent ultrasound-guided aspiration...
October 5, 2018: Muscle & Nerve
Peter W Reddien
Regeneration is one of the great mysteries of biology. Planarians are flatworms capable of dramatic feats of regeneration, which have been studied for over 2 centuries. Recent findings identify key cellular and molecular principles underlying these feats. A stem cell population (neoblasts) generates new cells and is comprised of pluripotent stem cells (cNeoblasts) and fate-specified cells (specialized neoblasts). Positional information is constitutively active and harbored primarily in muscle, where it acts to guide stem cell-mediated tissue turnover and regeneration...
October 4, 2018: Cell
Thimo Maurer, Michael H Stoffel, Yury Belyaev, Niklaus G Stiefel, Beatriz Vidondo, Susanne Küker, Helga Mogel, Birgit Schäfer, Jasmin Balmer
Collagen is the main structural element of connective tissues, and its favorable properties make it an ideal biomaterial for regenerative medicine. In dental medicine, collagen barrier membranes fabricated from naturally occurring tissues are used for guided bone regeneration. Since the morphological characteristics of collagen membranes play a crucial role in their mechanical properties and affect the cellular behavior at the defect site, in-depth knowledge of the structure is key. As a base for the development of novel collagen membranes, an extensive morphological analysis of four porcine membranes, including centrum tendineum, pericardium, plica venae cavae and small intestinal submucosa, was performed...
2018: PloS One
Arash Khojasteh, Sepanta Hosseinpour, Maryam Rezai Rad, Marzieh Alikhasi
This case report sought to describe efficient clinical applications of adipose- derived stem cells (AdSCs) originated from buccal fat pad (BFP) in combination with conventional guided bone regeneration as protected healing space for reconstruction of large alveolar defects after multi-impacted teeth extractions. The first case was a 19-year-old female with several impacted teeth in the maxillary and mandibular regions, which were not capable to forced erupt and recommended by the orthodontist for surgical extraction...
October 3, 2018: Journal of Oral Implantology
Leandro Chambrone, Maria Aparecida Salinas Ortega, Flávia Sukekava, Roberto Rotundo, Zamira Kalemaj, Jacopo Buti, Giovan Paolo Pini Prato
BACKGROUND: Gingival recession is defined as the oral exposure of the root surface due to a displacement of the gingival margin apical to the cemento-enamel junction and it is regularly linked to the deterioration of dental aesthetics. Successful treatment of recession-type defects is based on the use of predictable root coverage periodontal plastic surgery (RCPPS) procedures. This review is an update of the original version that was published in 2009. OBJECTIVES: To evaluate the efficacy of different root coverage procedures in the treatment of single and multiple recession-type defects...
October 2, 2018: Cochrane Database of Systematic Reviews
Jungtae Lee, Dajung Lee, Seo-Eun Oh, Kyeong-Mee Park, Kyung-Seok Hu, Sungtae Kim
OBJECTIVE: Barrier membranes are important in maintaining space in guided bone regeneration process by preventing downgrowth of epithelial or connective tissue. In this study, the effects of resorbable membranes during the early stages of bone regeneration in rats with impaired bone healing capacity were investigated. STUDY DESIGN: Twenty-eight rats were selected for this study. Half of the animals were selected for radiation therapy before surgical procedure (G3, G4)...
July 20, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
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