Read by QxMD icon Read

Guided regeneration

S Preethi Soundarya, A Haritha Menon, S Viji Chandran, N Selvamurugan
In the recent years, a paradigm shift is taking place where metallic/synthetic implants and tissue grafts are being replaced by tissue engineering approach. A well designed three-dimensional scaffold is one of the fundamental tools to guide tissue formation in vitro and in vivo. Bone is a highly dynamic and an integrative tissue, and thus enormous efforts have been invested in bone tissue engineering to design a highly porous scaffold which plays a critical role in guiding bone growth and regeneration. Numerous techniques have been developed to fabricate highly interconnected, porous scaffold for bone tissue engineering applications with the help of biomolecules such as chitosan, collagen, gelatin, silk, etc...
August 11, 2018: International Journal of Biological Macromolecules
John C O'Donnell, Kritika S Katiyar, Kate V Panzer, D Kacy Cullen
New neurons are integrated into the circuitry of the olfactory bulb throughout the lifespan in the mammalian brain-including in humans. These new neurons are born in the subventricular zone and subsequently mature as they are guided over long distances via the rostral migratory stream through mechanisms we are only just beginning to understand. Regeneration after brain injury is very limited, and although some neuroblasts from the rostral migratory stream will leave the path and migrate toward cortical lesion sites, this neuronal replacement is generally not sustained and therefore does not provide enough new neurons to alleviate functional deficits...
August 2018: Neural Regeneration Research
Mario Pérez-Sayáns, Alejandro I Lorenzo-Pouso, Pablo Galindo-Moreno, Fernando Muñoz-Guzón, Antonio González-Cantalapiedra, Mónica López-Peña, Manuel Somoza-Martín, Mercedes Gallas-Torreira, Abel García-García
This study compared the in vivo behavior of two biomaterials, xenograft (Bio-Oss® ) and alloplastic tricalcium phosphate (Sil-Oss® ), vs a control (no biomaterial) in beagle dogs treated with guided bone regeneration (GBR). Six male adult beagle dogs were included. The third and fourth mandibular premolars and first mandibular molars (3P3, 4P4 and 1M1) on both sides were extracted. After 12 weeks of healing, Straumann implants (3.3 × 8 mm) were placed, performing standardized defects (3.3 × 6 mm) in the vestibular aspect of the alveolar bone...
August 9, 2018: Odontology
Tinke-Marie De Witte, Lidy E Fratila-Apachitei, Amir A Zadpoor, Nicholas A Peppas
In recent years, bone tissue engineering has emerged as a promising solution to the limitations of current gold standard treatment options for bone related-disorders such as bone grafts. Bone tissue engineering provides a scaffold design that mimics the extracellular matrix, providing an architecture that guides the natural bone regeneration process. During this period, a new generation of bone tissue engineering scaffolds has been designed and characterized that explores the incorporation of signaling molecules in order to enhance cell recruitment and ingress into the scaffold, as well as osteogenic differentiation and angiogenesis, each of which is crucial to successful bone regeneration...
August 2018: Regenerative Biomaterials
Felipe Eduardo Pinotti, Guilherme José Pimentel Lopes de Oliveira, Cássio Rocha Scardueli, Marcell Costa de Medeiros, Andreas Stavropoulos, Rosemary Adriana Chiérici Marcantonio
PURPOSE: To assess whether the use of a non-crosslinked porcine collagen type I and III bi-layered membrane inter-positioned between the periosteum and a bone defect would interfere with the bone regenerative capacity of the periosteum. MATERIALS AND METHODS: Sixty rats, each with 1 critical-size calvarial defect (CSD; diameter, 5 mm) in the parietal bone, were randomly allocated to 1 of 3 equal-size groups after CSD creation: 1) the periosteum was excised and the flap was repositioned without interposition of a membrane (no-periosteum [NP] group); 2) the flap including the periosteum was repositioned (periosteum [P] group); and 3) a non-crosslinked collagen membrane was inter-positioned between the flap, including the periosteum, and the bone defect (membrane [M] group)...
August 6, 2018: Journal of Oral and Maxillofacial Surgery
Yihu Wang, Ming Ma, Jianing Wang, Weijie Zhang, Weipeng Lu, Yunhua Gao, Bing Zhang, Yanchuan Guo
Gelatin-based hydrogel, which mimics the natural dermal extracellular matrix, is a promising tissue engineering material. However, insufficient and uncontrollable mechanical and degradation properties remain the major obstacles for its application in medical bone regeneration material. Herein, we develop a facile but efficient strategy for a novel hydrogel as guided bone regeneration (GBR) material. In this study, methacrylic anhydride (MA) has been used to modify gelatin to obtain photo-crosslinkable methacrylated gelatin (GelMA)...
August 3, 2018: Materials
Gi-Young Seo, Daniel Stefan Thoma, Ui-Won Jung, Jung-Seok Lee
OBJECTIVES: To histologically determine the alteration in horizontal mucosal thickness at sites that received guided bone regeneration (GBR) with additional use of collagen matrix and to assess whether bone formation is affected by adding collagen matrix at GBR sites at 8 weeks of healing. MATERIALS AND METHODS: Eight weeks after bilateral extraction of maxillary premolars, standardized defects were created on buccal side of edentulous ridges in four beagle dogs...
August 6, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Haifei Shi, Tingting Weng, Chunmao Han, Xingang Wang
In human adults, the repair of cutaneous wounds usually leads to scar formation rather than regeneration. Dermal substitutes have been used as a regenerative template for reducing scar formation and improving the extent of dermal regeneration. However, achievement of complete regeneration is still a long way off. Dermal substitutes are characterized by unusual regenerative activity, appearing to function by acting as temporary configurational guides for cell infiltration and synthesis of new stroma. Fibroblasts are important cells with many vital functions in wound-healing processes...
August 6, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Dharaminder Singh, Adam J Harding, Emad Albadawi, Fiona M Boissonade, John W Haycock, Frederik Claeyssens
Entubulating devices to repair peripheral nerve injuries are limited in their effectiveness particularly for critical gap injuries. Current clinically used nerve guidance conduits are often simple tubes, far stiffer than that of the native tissue. This study assesses the use of poly(glycerol sebacate methacrylate) (PGSm), a photocurable formulation of the soft biodegradable material, PGS, for peripheral nerve repair. The material was synthesized, the degradation rate and mechanical properties of material were assessed and nerve guidance conduits were structured via stereolithography...
July 31, 2018: Acta Biomaterialia
David González, Gustavo Cabello, Gema Olmos, Emilia López Hernández, Carlos L Niñoles
The buccal bone wall is the part of the socket of an anterior tooth that is most susceptible to resorption. Immediate implants offer advantages in terms of time, comfort, and esthetics, especially regarding the maintenance of the papillae architecture. However, the loss of the buccal bone wall is often a limitation for such a therapy. This case report describes a clinical procedure designed to reconstruct the buccal bone wall to restore an anterior tooth where this wall was absent. The approach involved a flapless immediate implant based on the principles of guided bone regeneration (GBR), and consisted of the preparation of a large, flapless recipient bed ad modum envelope, immediate implant placement, deposition of xenograft surrounding the implant surface, and coverage with a collagen membrane...
2018: International Journal of Esthetic Dentistry
Yuanyuan Wang, Silvana Papagerakis, Denver Faulk, Stephen F Badylak, Yuming Zhao, Lihong Ge, Man Qin, Petros Papagerakis
Objective: Periodontitis affects nearly 90% of adults over the age of 70, resulting to periodontal tissue infection, destruction, and ultimately tooth loss. Guided tissue regeneration (GTR) is a method widely used to treat severe periodontal disease, and involves placement of an occlusive barrier to facilitate regeneration of the damaged area by periodontal ligament stem cells (PDLSCs). In this study, we evaluate natural extracellular matrix (ECM) as a scaffold material to provide a suitable microenvironment to support the proliferation, differentiation, and tissue-regenerating properties of PDLSCs...
2018: Frontiers in Physiology
Markus Witzler, Abla Alzagameem, Michel Bergs, Basma El Khaldi-Hansen, Stephanie E Klein, Dorothee Hielscher, Birgit Kamm, Judith Kreyenschmidt, Edda Tobiasch, Margit Schulze
Renewable resources are gaining increasing interest as a source for environmentally benign biomaterials, such as drug encapsulation/release compounds, and scaffolds for tissue engineering in regenerative medicine. Being the second largest naturally abundant polymer, the interest in lignin valorization for biomedical utilization is rapidly growing. Depending on its resource and isolation procedure, lignin shows specific antioxidant and antimicrobial activity. Today, efforts in research and industry are directed toward lignin utilization as a renewable macromolecular building block for the preparation of polymeric drug encapsulation and scaffold materials...
July 27, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Haeri Kim, Gi Hoon Yang, Chang Hyun Choi, Yong Suk Cho, GeunHyung Kim
Tissue engineering aims to repair or replace damaged tissues or organs using biomedical scaffolds cultured with cells. The scaffolds composed of biomaterials should guide the cells to mature into functional tissues or organs. An ideal scaffold to regenerate hard tissues should have mechanical stability as well as biocompatibilities. It has been well known that gelatin can provide outstanding biological activities, but its low mechanical stability can be one of obstacles to be used in hard tissue regeneration...
July 26, 2018: International Journal of Biological Macromolecules
Consuelo C Zumarán, Marcelo V Parra, Sergio A Olate, Eduardo G Fernández, Francisco T Muñoz, Ziyad S Haidar
Platelet-Rich fibrin (PRF) is a three-dimensional (3-D) autogenous biomaterial obtained via simple and rapid centrifugation from the patient's whole blood samples, without including anti-coagulants, bovine thrombin, additives, or any gelifying agents. At the moment, it is safe to say that in oral and maxillofacial surgery, PRFs (particularly, the pure platelet-rich fibrin or P-PRF and leukocyte and platelet-rich fibrin or L-PRF sub-families) are receiving the most attention, essentially because of their simplicity, cost-effectiveness, and user-friendliness/malleability; they are a fairly new "revolutionary" step in second-generation therapies based on platelet concentration, indeed...
July 26, 2018: Materials
Yunji Wang, Ye Qiu, Jie Li, Chunliang Zhao, Jinlin Song
Periodontitis is a common oral disease characterized by progressive destruction of periodontal tissue and loss of teeth. However, regeneration of periodontal tissue is a time-consuming process. Low-intensity pulsed ultrasound (LIPUS) is a widely used non-invasive intervention for enhancing bone healing in fractures and non-unions. With the hypothesis that LIPUS may accelerate periodontal regeneration, the effects of LIPUS on periodontal tissue regeneration were investigated both in vitro and in vivo. LIPUS (90 mw/cm2 , 20 min/d, 1...
November 2018: Ultrasonics
Brian J Green, Kristan S Worthington, Jessica R Thompson, Spencer J Bunn, Mary Rethwisch, Emily E Kaalberg, Chunhua Jiao, Luke A Wiley, Robert F Mullins, Edwin M Stone, Elliott H Sohn, Budd A Tucker, C Allan Guymon
Degradable polymers are integral components in many biomedical polymer applications. The ability of these materials to decompose in situ has become a critical component for tissue engineering, allowing scaffolds to guide cell and tissue growth while facilitating gradual regeneration of native tissue. The objective of this work is to understand the role of prepolymer molecular weight and functionality of photocurable poly(caprolactone) (PCL) in determining reaction kinetics, mechanical properties, polymer degradation, biocompatibility, and suitability for stereolithography...
August 9, 2018: Biomacromolecules
Lihong Lei, Yuanyuan Yu, Ting Ke, Weilian Sun, Lili Chen
A 36-year-old male patient diagnosed with severe chronic periodontitis was treated with novel surgery for his maxillary right lateral incisor. Preoperatively, a 3D printer was used to produce a photosensitive resin bony anatomy replica based on CBCT datasets. The patient's blood was centrifuged to obtain advanced platelet-rich fibrin (A-PRF) and Injected platelet-rich fibrin (I-PRF), which were mixed with Bio-Oss, and packed onto the 3D replica to form the ideal shape. The replica was then positioned at the planned sites without any change...
July 25, 2018: Journal of Oral Implantology
Arne Hendrik Boecker, Ahmet Bozkurt, Bong Sung Kim, Haktan Altinova, Julian Tank, Ronald Deumens, Rene Tolba, Joachim Weis, Gary Anthony Brook, Norbert Pallua, Sabien Geraldine Antonia van Neerven
The reconstruction of peripheral nerve injuries is clinically challenging, and today the autologous nerve transplantation is still considered as the only gold standard remedy for nerve lesions where a direct nerve coaptation is not possible. Nevertheless, the functional merits of many biomaterials have been tested as potential substitutes for the autologous nerve transplant. One of the strategies that have been pursued is the combination of bio-engineered nerve guides with cellular enrichment. In this present study, we combined the previously evaluated collagen-based and micro-structured nerve guide Perimaix with olfactory ensheathing cell enrichment...
July 25, 2018: Journal of Tissue Engineering and Regenerative Medicine
Margarita Trobos, Annika Juhlin, Furqan A Shah, Maria Hoffman, Herman Sahlin, Christer Dahlin
AIM: This study evaluates biofilm formation and barrier function against Streptococcus oralis of nonresorbable polytetrafluoroethylene (PTFE) guided bone regeneration membranes having expanded (e-PTFE) and dense (d-PTFE) microstructure. MATERIALS AND METHODS: Three e-PTFE membranes of varying openness, one d-PTFE membrane, and commercially pure titanium discs were evaluated. All e-PTFE membranes consisted of PTFE nodes interconnected by fibrils. The d-PTFE membrane was fibril-free, with large evenly spaced indentations...
July 24, 2018: Clinical Implant Dentistry and related Research
Xiao Li, Li Tang, Yong Feng Lin, Gui Fang Xie
BACKGROUND: Postoperative wound healing is an important part of the success of the dental implant surgery. However, in case of complex surgery or unfavorable factors, wound healing is often unsatisfactory. OBJECTIVE: The aim of this study was to explore the effects of vitamin C supplementation in wound healing, following the placement of dental implants with or without bone grafts and patients with chronic periodontitis. METHODS: This randomized controlled clinical trial included 128 patients requiring dental implants to replace missing teeth...
July 24, 2018: Clinical Implant Dentistry and related Research
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"