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Botulinum cosmetic

Matteo Caleo, Matteo Spinelli, Francesca Colosimo, Ivica Matak, Ornella Rossetto, Zdravko Lackovic, Laura Restani
Botulinum neurotoxin type A (BoNT/A) is an effective treatment for several movement disorders, including spasticity and dystonia. BoNT/A acts by cleaving synaptosomal-associated protein of 25 kDa (SNAP-25) at the neuromuscular junction, thus blocking synaptic transmission and weakening overactive muscles. However, not all the therapeutic benefits of the neurotoxin are explained by peripheral neuroparalysis, suggesting an action of BoNT/A on central circuits. Currently, the specific targets of BoNT/A central activity remain unclear...
October 12, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Michael B Lewis
Botulinum toxin (BTX) injections reduce muscle mobility and are commonly used to treat the appearance of glabellar frown lines. Research shows that this cosmetic treatment leads to a reduction in depression. This reduction is consistent with the theory of embodied emotions because patients have a reduced ability to frown and so receive less negative feedback associated with this action. The current research explored this effect and three further hypotheses for the effects of cosmetic BTX injections based on embodied emotions...
October 3, 2018: Scientific Reports
Joris R de Groot
No abstract text is available yet for this article.
September 18, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Akash Dhawan, Sunil Dhawan, Domenico Vitarella
Botulinum toxins have been utilized in a number of cosmetic and therapeutic applications. One of the more novel uses of botulinum toxin involves its use to mitigate the effects of superficial cutaneous scarring. This is accomplished by decreasing the dynamic tension of a wound by denervating the underlying muscle. Studies have indicated that botulinum toxin serotypes A and B have a positive effect on wound healing and scar appearance. However, larger prospective, blinded, randomized, placebo-controlled clinical trials are required to refine this concept and target optimum toxin dose placement, timing, and concentration...
September 1, 2018: Journal of Drugs in Dermatology: JDD
Mi-Sun Hur, Kwan Hyun Youn, Hee-Jin Kim
The present study aimed to determine the arrangement and terminal attachments of the zygomaticus minor muscle (Zmi) fibers connecting the orbital and mouth regions. The Zmi was examined in 32 specimens of embalmed Korean adult cadavers. The Zmi was present in all 32 specimens (100%). In 31 of the specimens (96.9%), the Zmi that inserted into the upper lip was formed by muscle fibers that arose from the zygomatic bone and muscle fibers that extended from the orbicularis oculi muscle (OOc). In 14 of the specimens (43...
September 8, 2018: Clinical Anatomy
Lili Bai, Xiaobo Peng, Yanqing Liu, Yawei Sun, Xin Wang, Xingwang Wang, Guodong Lin, Peng Zhang, Kun Wan, Zewu Qiu
This study was conducted to analyze the clinical characteristics of and treatment strategies for botulism among patients receiving cosmetic injection of botulinum toxin (BoNT).A total of 86 botulism patients caused by cosmetic injection of BoNT were enrolled in our study. All of the patients were diagnosed according to their history of cosmetic BoNT injection, clinical symptoms and signs, and other auxiliary examinations (including those on renal and liver functions, blood index detection, and chest X-ray)...
August 2018: Medicine (Baltimore)
Roy Kazan, Mirko S Gilardino
No abstract text is available yet for this article.
August 22, 2018: Aesthetic Surgery Journal
Dario Bertossi, Maurizio Cavallini, Pierfrancesco Cirillo, Salvatore Piero Fundarò, Sandro Quartucci, Chantal Sciuto, Davide Tonini, Gloria Trocchi, Massimo Signorini
BACKGROUND: The aesthetic treatment of facial and neck wrinkles with botulinum toxin is constantly increasing, thus making it necessary to collect procedures guidelines for the use of botulinum toxin in the treatment of wrinkles and/or cosmetic defects. METHODS: A group of nine Italian doctors, plastic and maxillo-facial surgeons, dermatologists and aesthetic physicians, experts in face and neck aesthetic treatments with onabotulinum toxin A, discussed on procedures used in their clinical practice...
August 9, 2018: Journal of Cosmetic Dermatology
Mehri Salari, Soumya Sharma, Mandar S Jog
Botulinum neurotoxins (BoNTs) produce local chemo-denervation by cleaving soluble N-ethylmaleimide-sensitive factor activating protein receptor (SNARE) proteins. Botulinum neurotoxins are therapeutically indicated in several neurological disorders and have been in use for three decades. The long-term efficacy, safety, and side effects of BoNTs have been well documented in the literature. However, the development of muscle atrophy following chronic exposure to BoNTs has not received sufficient attention. Muscle atrophy is not only cosmetically distressing, but also has an impact on future injections...
August 2, 2018: Toxins
Yue-Hua Li, Jiaomei Yang, Jia-Qi Liu, Song-Tao Xie, Yi-Jie Zhang, Wei Zhang, Ju-Lei Zhang, Zhao Zheng, Da-Hai Hu
BACKGROUND: Linear hypertrophic scar is a common surgical problem that can be difficult to manage, especially for the median sternotomy scar. Botulinum toxin type A (BTA) is widely used in cosmetic surgery and has been shown to improve scar quality recently. The aim of this study was to evaluate the efficacy of BTA injected in the early postoperative of median sternotomy on preventing scar formation. METHODS: In this prospective randomized controlled trial, 19 consecutive patients who underwent median sternotomy were enrolled...
July 17, 2018: Aesthetic Plastic Surgery
Richard C Allen
PURPOSE OF REVIEW: Periocular rehabilitation of the patient with a facial nerve palsy has evolved over time. Although protection of the ocular surface is paramount, application of disfiguring tarsorrhaphies should be utilized only in special situations. The purpose of this review is to discuss current surgical and medical strategies in treatment of the periocular area in patients with facial nerve palsy to give maximal functional and cosmetic results. RECENT FINDINGS: Upper lid lagophthalmos is preferentially treated with upper eyelid weights...
September 2018: Current Opinion in Ophthalmology
Mario V Mitkov, Colleen S Thomas, Jordan J Cochuyt, Antonio J Forte, Galen Perdikis
Background: Learning to inject botulinum toxin for cosmetic purposes is difficult for beginners given the nature of the procedure and patient population. Simulation training is an effective modality for medical professionals to acquire skills in an environment that provides low stress and ample opportunity for questions and correction of mistakes. Objective: Compare posttraining comfort, knowledge, and practical botulinum toxin injection scores between trainees who underwent simulation versus video training only...
July 3, 2018: Aesthetic Surgery Journal
Dagmar Scharschmidt, Ursula Mirastschijski, Simone Preiss, Elmar Brähler, Tanja Fischer, A Borkenhagen
BACKGROUND: The demand for minimally invasive cosmetic procedures has continued to rise, especially in Germany, yet few studies have examined this patient population. The literature in Germany has repeatedly voiced the speculation that users of minimally invasive, skin-rejuvenating procedures displayed a higher tendency toward dysmorphic behavior patterns or, respectively, other abnormal personality traits. OBJECTIVES: The aim of this study was to investigate body image, personality traits, quality of life, and socioeconomic parameters in users of botulinum toxin and/or facial fillers...
August 2018: Aesthetic Plastic Surgery
Souphiyeh Samizadeh, Koenraad De Boulle
Botulinum toxin A is produced by anaerobic spore-forming bacteria and is used for various therapeutic and cosmetic purposes. Botulinum toxin A injections are the most popular nonsurgical procedure worldwide. Despite an increased demand for botulinum toxin A injections, the clinical pharmacology and differences in formulation of commonly available products are poorly understood. The various products available in the market are unique and vary in terms of units, chemical properties, biological activities, and weight, and are therefore not interchangeable...
2018: Clinical, Cosmetic and Investigational Dermatology
Alexander Hawlitschka, Andreas Wree
Parkinson’s disease (PD) is one of the most frequent neurodegenerative disorders. Its main pathophysiological characteristic is the loss of dopaminergic neurons in the substantia nigra pars compacta followed by a lack of striatal dopaminergic input and a consequent disinhibition of tonically active cholinergic interneurons. The resulting striatal hypercholinism causes major motor symptoms in PD. Anticholinergic pharmacotherapies have antiparkinsonian effects on motor symptoms, but, due to systemic actions, also numerous severe side effects occur on a regular basis...
May 7, 2018: International Journal of Molecular Sciences
Bardia Amirlak, Michael H Chung, Ronnie A Pezeshk, Kyle Sanniec
BACKGROUND: Surgical decompression of peripheral cranial and spinal nerves at several anatomically studied trigger sites has demonstrated significant efficacy in bringing permanent relief to migraine sufferers. In their experience performing frontal nerve decompression on migraine patients, the authors noticed a previously undescribed accessory nerve and vessel in the frontotemporal area, and report its implication in migraine surgery and cosmetic filler injection. METHODS: A retrospective review of 113 patients who underwent frontal migraine decompression surgery with the senior author at the University of Texas Southwestern Medical Center from July of 2012 to May of 2016 was performed...
May 2018: Plastic and Reconstructive Surgery
M Axel Wollmer, Insa Neumann, Michelle Magid, Tillmann H Kruger
Treating glabellar frown lines with injections of botulinum toxin is the most frequently applied procedure in aesthetic medicine. In addition to its cosmetic effect, botulinum toxin may also positively modulate mood and affect, which may contribute to its popularity. A series of clinical studies has shown that this modulation can be used in the treatment of major depression. After a single glabellar treatment with botulinum toxin, patients suffering from unipolar depression experienced a quick, strong and sustained improvement in the symptoms of depression...
August 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Iselin Saltvig, Steen Henrik Matzen
Background: Headache is a common disorder of the nervous system; chronic headache in particular may affect quality of life negatively. The pathophysiology is multifactorial and not completely elucidated. Studies have demonstrated the beneficial effects of botulinum toxin A on chronic migraine headaches, but failed to show the same effect on chronic tension-type headaches. Methods: We present the case of a 32-year-old woman who after receiving cosmetic injections with botulinum toxin A for fine lines of the forehead experienced relief of subclinical tension-type headaches...
September 2017: Case Reports in Dermatology
Ahmet Yildirim, Turgut Adatepe, Aysegul Gunduz, Orhan Yagiz, Nurten Uzun
Repetitive nerve stimulation (RNS) is a highly sensitive electrophysiological test used for diagnosing myasthenia gravis (MG). Here, we evaluated electrodiagnostic value of RNS using facial nerve and occipitalis muscle. Patients with generalized MG were included. Clinical findings were assessed. RNS test was performed on occipitalis, nasalis, trapezius, abductor policis brevis (APB) and abductor digiti minimi (ADM) muscles. Twenty-five (78%) patients had relevant decrement during RNS test of at least one muscle...
February 10, 2018: Acta Neurologica Belgica
Mehdi Gheisari, Behnaz Hamedani, RezaM Robati, Nikoo Mozafari
BACKGROUND: Multiple eccrine hidrocystomas (MEH) are benign cystic lesions of the sweat gland ducts. They are characterized by translucent, skin-colored or bluish dome-shaped papules on the face, causing cosmetic concern. Recently, botulinum toxin-A, because of its antiperspirant properties, has been used to treat facial MEH. However, there are only some case reports in the literature. OBJECTIVE: Here, we conducted a prospective study to assess the efficacy and safety of intralesional injection of botulinum toxin-A (Dysport) for the treatment of MEH...
January 31, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
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