Carlos García-Crespo, Ana Isabel de Ávila, Isabel Gallego, María Eugenia Soria, Antoni Durán-Pastor, Pilar Somovilla, Brenda Martínez-González, Javier Muñoz-Flores, Pablo Mínguez, Llanos Salar-Vidal, Mario Esteban-Muñoz, Elizabeth Cañar-Camacho, Cristina Ferrer-Orta, Sonia Zuñiga, Isabel Sola, Luis Enjuanes, Jaime Esteban, Ricardo Fernández-Roblas, Ignacio Gadea, Jordi Gómez, Nuria Verdaguer, Esteban Domingo, Celia Perales
BACKGROUND AND PURPOSE: There is a need for effective anti-COVID-19 treatments, mainly for individuals at risk of severe disease such as the elderly and the immunosuppressed. Drug repositioning has proved effective in identifying drugs that can find a new application for the control of coronavirus disease, in particular COVID-19. The purpose of the present study was to find synergistic antiviral combinations for COVID-19 based on lethal mutagenesis. EXPERIMENTAL APPROACH: The effect of combinations of remdesivir and ribavirin on the infectivity of SARS-CoV-2 in cell culture has been tested...
April 14, 2024: British Journal of Pharmacology