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Aptamer flowcytometry

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https://www.readbyqxmd.com/read/27702507/fabrication-of-aptamer-decorated-dextran-coated-nano-graphene-oxide-for-targeted-drug-delivery
#1
Mona Alibolandi, Marzieh Mohammadi, Seyed Mohammad Taghdisi, Mohammad Ramezani, Khalil Abnous
In the current study, dextran (DEX) was covalently conjugated to the surface of nano-GO sheets, making stable biocompatible dextran coated GO (GO-DEX). The prepared GO-DEX was nontoxic to 4T1 mammary carcinoma cell line at concentrations up to 300μg/mL. AS1411 aptamer, a ssDNA aptamer which can improve the intracellular uptake by nucleolin recognition, also has been introduced to hydroxyl groups of DEX in GO-DEX to produce GO-DEX-Apt. Moreover, curcumin (CUR), a natural polyphenol, found in the rhizomes of Curcuma longa (turmeric) which shows antineoplastic effects, was loaded onto the GO-DEX and GO-DEX-Apt via π-π stacking interactions with a high loading capacity (∼29wt%)...
January 2, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/22615073/as1411-aptamer-tagged-plga-lecithin-peg-nanoparticles-for-tumor-cell-targeting-and-drug-delivery
#2
Athulya Aravind, Prashanti Jeyamohan, Remya Nair, Srivani Veeranarayanan, Yutaka Nagaoka, Yasuhiko Yoshida, Toru Maekawa, D Sakthi Kumar
Liposomes and polymers are widely used drug carriers for controlled release since they offer many advantages like increased treatment effectiveness, reduced toxicity and are of biodegradable nature. In this work, anticancer drug-loaded PLGA-lecithin-PEG nanoparticles (NPs) were synthesized and were functionalized with AS1411 anti-nucleolin aptamers for site-specific targeting against tumor cells which over expresses nucleolin receptors. The particles were characterized by transmission electron microscope (TEM) and X-ray photoelectron spectroscopy (XPS)...
November 2012: Biotechnology and Bioengineering
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