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Pediatric GERD

Conor McCann, Paul S Cullis, Amanda J McCabe, Fraser D Munro
AIM OF THE STUDY: The aim of the study was to identify major gastrointestinal complications associated with direct jejunal feeding. We hypothesized that jejunal feeding may cause life-threatening surgical complications in a minority of patients. METHODS: All patients undergoing jejunal feeding between 1/2008 and 1/2018 at a pediatric surgical unit were identified retrospectively. Data sought from records included demographics, comorbidities, indications, feeding strategies, adverse events, and follow-up...
November 6, 2018: Journal of Pediatric Surgery
Marc Bardou, Kyle J Fortinsky, Nicolas Chapelle, Maxime Luu, Alan Barkun
Gastroesophageal reflux (GER), and its complicated form gastroesophageal reflux disease (GERD) is a common condition in infants and children. As GERD is often considered to cause extra-oesophageal symptoms in children and in the absence of standardized diagnostic and treatment algorithm, many children are inappropriately exposed to empirical anti-reflux treatments, with Acid-Suppressive Medications (ASM); mostly proton pump inhibitors (PPIs). Areas covered: The authors summarize the pharmacological management of pediatric GERD and discuss the efficacy of PPIs as randomized controlled trials have failed to demonstrate their clinical efficacy in the pediatric population...
November 29, 2018: Expert Opinion on Pharmacotherapy
Doyeon Kim, Eun Kyung Lee, Ji Seon Jeong, Nam-Su Gil, Tae Soo Hahm, Young Hee Shin
BACKGROUND: It is often difficult for the pediatric patient to cooperate or to remain immobile during MR scans. Therefore, sedation is usually needed for children. PURPOSE: To evaluate the incidence and contributing factors of unanticipated intubation during sedation for MRI scan in children. STUDY TYPE: Retrospective observational study. POPULATION/SUBJECTS: In all, 1165 charts were reviewed retrospectively of patients who had been sedated by anesthesiologists at a single institution from May 2015 to June 2016...
October 22, 2018: Journal of Magnetic Resonance Imaging: JMRI
Matea Kovačić, Josipa Unić, Zrinjka Mišak, Oleg Jadrešin, Vlatka Konjik, Sanja Kolaček, Iva Hojsak
BACKGROUND AND AIMS: Despite rising incidence of eosinophilic esophagitis (EoE), data on the follow-up and treatment outcomes in pediatric patients are scarce. Therefore, the aim of this study was to present data on the treatment outcomes in children diagnosed with EoE who were treated in a tertiary medical center. PATIENTS AND METHODS: A retrospective study involving patients younger than 18 years who were diagnosed with EoE in our center between January 2011 and June 2017...
October 19, 2018: Esophagus: Official Journal of the Japan Esophageal Society
Masoumeh Asgarshirazi, Monir Farokhzadeh-Soltani, Zarrintaj Keihanidost, Mamak Shariat
Objective: This cross sectional study aims to survey developing feeding disorders and nutritional deficiencies disorders in children with neurodevelopmental disorders such as cerebral palsy. Materials and methods: A total of 50 children (28 boys and 22 girls) with cerebral palsy and symptoms suggesting gastrointestinal problems such as choking, recurrent pneumonia and poor weight gain, who referred to the Pediatric department of Vali-asr Hospital, Imam Khomeini hospital complex between 1 October 2012 and 30 October 2013, were checked...
December 2017: Journal of Family & Reproductive Health
Gabor Kovacs, Daniel Dumitrescu, Andreas Barner, Sebastian Greiner, Ekkehard Grünig, Alfred Hager, Thomas Köhler, Rainer Kozlik-Feldmann, Irmtraut Kruck, Astrid E Lammers, Derliz Mereles, Andreas Meyer, Joachim Meyer, Stefan Pabst, Hans-Jürgen Seyfarth, Christoph Sinning, Stephan Sorichter, Gerd Stähler, Heinrike Wilkens, Matthias Held
In the summer of 2016, delegates from the German Society of Cardiology (DGK), the German Respiratory Society (DGP), and the German Society of Pediatric Cardiology (DGPK) met in Cologne, Germany, to define consensus-based practice recommendations for the management of patients with pulmonary hypertension (PH). These recommendations were built on the 2015 European Pulmonary Hypertension guidelines, aiming at their practical implementation, considering country-specific issues, and including new evidence, where available...
August 27, 2018: International Journal of Cardiology
Vasile Valeriu Lupu, Marin Burlea, Nicolai Nistor, Violeta Streanga, Magdalena Iuliana Starcea, Gabriela Paduraru, Dragos Catalin Ghica, Elena Cristina Mitrofan, Mihaela Moscalu, Ancuta Ignat
Gastroesophageal reflux (GER) is the intermittent or permanent passage of stomach content into the esophagus and gastroesophageal reflux disease (GERD) is the reflux which triggers a whole set of symptoms or complications. The study compares the 24-hours esophageal pH-metry, used for diagnosis of the GERD, with the esophagitis degree observed at the upper digestive endoscopy.72 children were included, aged over 4 years old, admitted in a pediatric gastroenterology regional center in Northeast Romania, diagnosed with GERD by 24 hours pH-metry (with a positive Boix-Ochoa score), which also underwent the upper digestive endoscopy...
September 2018: Medicine (Baltimore)
Paul E Beaulé, George Grammatopoulos, Andrew Speirs, K C Geoffrey Ng, Sasha Carsen, Hanspeter Frei, Gerd Melkus, Kawan Rakhra, Mario Lamontagne
This article reviews a body of work performed by the investigators over 9 years that has addressed the significance of cam morphology in the development of hip osteoarthritis (OA). Early hip joint degeneration is a common clinical presentation and preexisting abnormal joint morphology is a risk factor for its development. Interrogating Hill's criteria, we tested whether cam-type femoroacetabular impingement leads to hip OA. Strength of association was identified between cam morphology, reduced range-of-movement, hip pain, and cartilage degeneration...
September 3, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Daisuke Masui, Suguru Fukahori, Shinji Ishii, Naoki Hashizume, Nobuyuki Saikusa, Motomu Yoshida, Naruki Higashidate, Saki Sakamoto, Shiori Tsuruhisa, Hirotomo Nakahara, Yoshiaki Tanaka, Minoru Yagi
BACKGROUND: The present study aimed to evaluate whether the detailed observation of pH/MII waveforms and the analysis of baseline impedance (BI) values could detect esophageal dysmotility in pediatric patients with esophageal disorders. PATIENTS AND METHODS: Eleven patients with congenital esophageal disorder in whom pH/MII was conducted from April 2011 to June 2015, were enrolled in this study. The diagnoses of the patients were as follows: postoperative esophageal atresia (EA), n = 6; esophageal achalasia (EAch), n = 4; and congenital esophageal stenosis (CES), n = 1...
August 25, 2018: Esophagus: Official Journal of the Japan Esophageal Society
Daniel P Fox, Julina Ongkasuwan
Acute croup is a common admitting diagnosis for pediatric patients. If a patient is not responding to medical management for presumed croup, the otolaryngology team is occasionally consulted for direct laryngoscopy and bronchoscopy (DLB) to rule out tracheitis or another airway pathology. We conducted a study to determine if inpatient DLB in acute croup is safe and efficacious and to correlate preoperative vital signs with intraoperative findings. We reviewed the charts of 521 patients with an admitting diagnosis of acute tracheitis, acute laryngotracheitis, or croup...
August 2018: Ear, Nose, & Throat Journal
Molly Crenshaw, Molly Gribbin, Saba Qasmieh, Jessica Heil, Caitlin Ward, Steven Kariya, Jeremy Kern
INTRODUCTION: George Washington Students for Haiti conducts mobile clinics in the Central Plateau of Haiti. Baseline health data for specific rural areas of Haiti are needed. METHODS: Medical teams conducted mobile clinics in rural locations of Haiti's Central Plateau. Diagnoses, blood pressure, growth parameters, medications prescribed, and referrals were recorded. RESULTS: Analyses included 865 patients. The leading pediatric diagnoses were acute respiratory infection, dermatitis, and abdominal pain...
2018: Journal of Health Care for the Poor and Underserved
Stephanie Posten, Tonya Adamiak, Melissa Jensen
Eosinophilic esophagitis (EoE) is a chronic immune-mediated esophageal inflammatory disease that is becoming more widely recognized as a cause of feeding difficulties in infants and young children, as well as gastroesophageal reflux disease (GERD)-like symptoms, dysphagia, and food impaction in children and adolescents. The diagnosis of EoE is clinicopathologic, based on endoscopic, histologic, and clinical findings. Patients with suspected eosinophilic esophagitis require an endoscopy with biopsies. The diagnosis requires the presence of 15 or more intraepithelial eosinophils/HPF in at least one endoscopic esophageal mucosal biopsy...
August 2018: South Dakota Medicine: the Journal of the South Dakota State Medical Association
Gerd Horneff, Marieke M B Seyger, Dilek Arikan, Jasmina Kalabic, Jaclyn K Anderson, Andreas Lazar, David A Williams, Chen Wang, Rita Tarzynski-Potempa, Jeffrey S Hyams
OBJECTIVE: To evaluate the safety of adalimumab in pediatric patients who participated in clinical trials of juvenile idiopathic arthritis (polyarticular juvenile idiopathic arthritis and pediatric enthesitis-related arthritis), psoriasis, and Crohn's disease. STUDY DESIGN: This analysis included data from 7 global, randomized, and open-label AbbVie-sponsored clinical trials of adalimumab and their open-label extensions conducted between September 2002 and December 31, 2015 (cutoff date for ongoing studies)...
July 25, 2018: Journal of Pediatrics
Anna Byrjalsen, Ulrik Stoltze, Karin Wadt, Lisa Lyngsie Hjalgrim, Anne-Marie Gerdes, Kjeld Schmiegelow, Ayo Wahlberg
With an impending introduction of genome sequencing into paediatric oncology to facilitate personalised medicine, this study examines parent perspectives on participating in whole genome sequencing (WGS) research in the difficult weeks following diagnosis. As an embedded part of Sequencing Tumor and Germline DNA-Implications and National Guidelines (STAGING), a project aiming to implement WGS of all newly diagnosed paediatric cancer patients in Denmark, a parent perspective study was conducted by a clinical geneticist and anthropologist to document pragmatic, social and ethical dilemmas...
November 2018: European Journal of Cancer Care
Kothimbakkam Sai Sarath Kumar, Jayanthi Mungara, Nilaya Reddy Venumbaka, Poornima Vijayakumar, Deebiga Karunakaran
Aims: This study aimed to document the prevalence of oral manifestations seen among pediatric gastroesophageal reflux disease (GERD) patients in Chennai, Tamil Nadu, India. Methodology: This study was performed at various children's hospitals in Chennai. Fifty-one GERD patients who were assessed by endoscopy and 24 h pH-metry, 31 (60.78%) males and 20 (39.21%) females, aged 2-12 years (mean age, 7.43 years), comprised the study group. All patients answered a detailed frequency questionnaire related to regurgitation and acidic foods and participated in a clinical dental examination...
April 2018: Journal of the Indian Society of Pedodontics and Preventive Dentistry
Nina F Steutel, Miranda W Langendam, Marc A Benninga, Minke E P Jansen, Merit M Tabbers
OBJECTIVE: Acid-suppressant prescriptions for children have increased over past decades, despite guideline recommendations to prescribe prudently. Acid suppressants are often ineffective and may lead to side effects. We aimed to reduce inappropriate acid-suppressant prescriptions for gastroesophageal reflux in a tertiary care setting through active implementation of national guideline recommendations and to evaluate intervention effect. METHODS: Implementation consisted of 2 steps...
November 2018: Journal of Pediatric Gastroenterology and Nutrition
Robert Smigiel, Gerd Landsberg, Maximilian Schilling, Małgorzata Rydzanicz, Agnieszka Pollak, Anna Walczak, Anna Stodolak, Piotr Stawinski, Hanna Mierzewska, Maria M Sasiadek, Oliver J Gruss, Rafal Ploski
PTPN23 encodes a ubiquitously expressed non-receptor type, catalytically inactive protein-tyrosine phosphatase found in all cells including neurons. Recently, we have identified PTPN23 in a cellular screen for the systematic identification of novel regulators of survival motor neuron (SMN) function in the assembly of splicing factors (Uridine-rich small nuclear ribonucleoproteins, UsnRNPs). Based on three families, recessive PTPN23 variants have been associated with human disease tentatively, without functional studies...
June 13, 2018: European Journal of Human Genetics: EJHG
Carolina Gutiérrez-Junquera, Sonia Fernández-Fernández, M Luz Cilleruelo, Ana Rayo, Enriqueta Román
Eosinophilic esophagitis (EoE) is a chronic, local, immune-mediated disorder characterized by symptoms of esophageal dysfunction and the presence of a dense eosinophilic infiltrate in the esophageal mucosa. Consensus diagnostic recommendations for EoE diagnosis included absence of histological response to a proton-pump inhibitor (PPI) trial, to exclude gastro-oesophageal reflux disease (GERD)-associated esophagitis. This recommendation exposed an entity known as "proton pump inhibitor-responsive esophageal eosinophilia" (PPI-REE), which refers to patients with EoE phenotype who are PPI-responsive and do not present GERD...
2018: Frontiers in Pediatrics
Miriam Listing, Kirsten Mönkemöller, Ina Liedmann, Martina Niewerth, Claudia Sengler, Joachim Listing, Dirk Foell, Arnd Heiligenhaus, Ariane Klein, Gerd Horneff, Gerd Ganser, Johannes-Peter Haas, Jens Klotsche, Kirsten Minden
BACKGROUND: Achieving the best possible health-related quality of life (HRQoL) for a patient is an important treatment goal in juvenile idiopathic arthritis (JIA). We investigated the 36-month trajectories of HRQoL in children with JIA compared with healthy peers and identified the predictors of an unfavorable HRQoL. METHODS: Patients with a recent JIA diagnosis were enrolled in the German inception cohort study ICON. As a peer group, friends of patients of the same age and sex were asked to cooperate...
May 30, 2018: Arthritis Research & Therapy
Samuel Wittekind, Wayne Mays, Yvette Gerdes, Sandra Knecht, John Hambrook, William Border, John Lynn Jefferies
Patients with a Fontan circulation have impaired exercise capacity. Cardiac rehabilitation (CR) has shown promise in enhancing peak exercise parameters in this population, but an improvement in submaximal exercise has not been consistently demonstrated. We assessed the hypothesis that participation in CR will be associated with more efficient oxygen extraction and ventilation during submaximal exercise. In this prospective study, pediatric Fontans completed two 60 min CR sessions per week for 12 weeks. Cardiopulmonary exercise testing and stress echocardiography were performed at baseline and last CR session, and then compared with a paired sample t test...
June 2018: Pediatric Cardiology
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