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sleep AND disorder

Sungyang Jo, Hyun-Woo Kim, Ji Ye Jeon, Sang-Ahm Lee
BACKGROUND: This study investigated the protective effect of rapid eye movement (REM) sleep without atonia against obstructive sleep apnea (OSA) in patients with idiopathic REM sleep behavior disorder (RBD). METHODS: In this case-control study, patients with idiopathic RBD and OSA (RBD-OSA) were consecutively enrolled and OSA controls without RBD were matched for age, sex, and apnea-hypopnea index (AHI). Clinical and polysomnographic characteristics were compared between RBD-OSA patients and OSA controls...
November 19, 2018: Sleep Medicine
Shobi Sivathamboo, Sarah Farrand, Zhibin Chen, Elise J White, Andrew Andreas Pattichis, Callum Hollis, John Carino, Caitlin J Roberts, Thomas Minogue, Nigel C Jones, Raju Yerra, Christopher French, Piero Perucca, Patrick Kwan, Dennis Velakoulis, Terence J O'Brien, Jeremy Goldin
OBJECTIVE: To examine the prevalence and risk factors of sleep-disordered breathing (SDB) in individuals with epilepsy and psychogenic nonepileptic seizures (PNES). METHODS: We conducted a cross-sectional study of consecutive patients admitted for inpatient video-EEG monitoring at The Royal Melbourne Hospital, Australia, between December 1, 2011, and July 31, 2017. Participants underwent routine clinical investigations during their monitoring period including polysomnography, neurocognitive testing, and screening instruments of daytime somnolence, sleep quality, and quality of life...
December 14, 2018: Neurology
Eric D Achtyes, Dror Ben-Zeev, Zhehui Luo, Heather Mayle, Brandi Burke, Armando J Rotondi, Jennifer D Gottlieb, Mary F Brunette, Kim T Mueser, Susan Gingerich, Piper S Meyer-Kalos, Patricia Marcy, Nina R Schooler, Delbert G Robinson, John M Kane
INTRODUCTION: Technology-delivered healthcare interventions may enhance dissemination of evidence-based treatments in low-resource areas. These interventions may be accessed 'on-demand,' including after hours. Patients with schizophrenia do engage with technological aids but when/how they would utilize these tools is not known. METHODS: We conducted a large, prospective, ten-site, longitudinal study of four technology-assisted interventions for patients with schizophrenia spectrum disorders within 60 days of psychiatric hospital discharge, a high risk period...
December 11, 2018: Schizophrenia Research
Banafsheh Nikfar, Bahram Moazzami, Shahla Chaichian, Leila Ghalichi, Mahnaz Ekhlasi-Hundrieser, Mohammadreza Chashmyazdan, Batool Kazemi, Fatemeh Soltan, Mahshid Bozorgizadeh, Meisam Akhlaghdoust, Marzie Salehi, Yousef Alimohamadi
BACKGROUND: Having good quality of sleep is essential to good health. Sleep disorders could incur intangible expenses. The aim of this cross-sectional study was to evaluate the Persian version of the Pittsburgh Sleep Quality Index (PSQI-P) questionnaire administered to 3 categories of workers (clinical personnel, clerical staff, and logistics workers) in a private hospital located in Tehran, Iran. METHODS: In 2017, all Pars hospital personnel were invited to participate in the study...
November 1, 2018: Archives of Iranian Medicine
Ka-Fai Chung, Yvonne Patricia Yuan-Ping Poon, Ting-Kin Ng, Chui-Kwan Kan
Circadian rhythm disruption, manifested as circadian misalignment, difficulty initiating sleep, and sleep-wake irregularity, is often left unrecognized in patients with schizophrenia. Studies have shown multiple adverse consequences of sleep irregularity, but limited data is available on schizophrenia. This is a secondary analysis of a case-control study of 66 schizophrenia patients with delayed sleep-wake phase (with or without meeting criteria for the disorder) and normal sleep-wake phase (mean age = 44...
December 2018: Psychiatry Research
András Szentkirályi, Ambra Stefani, Heinz Hackner, Maria Czira, Inga K Teismann, Henry Völzke, Beate Stubbe, Sven Gläser, Ralf Ewert, Thomas Penzel, Ingo Fietze, Peter Young, Birgit Högl, Klaus Berger
Study Objectives: Periodic limb movements in sleep (PLMS) are frequent motor phenomena; however, population-based data are scarce. We assessed the prevalence of PLMS and factors associated with PLMS within two German population-based cohorts, the SHIP-TREND and BiDirect. Methods: Single-night polysomnography was performed on 1107 subjects recruited from the general population (mean age: 52.9 years, 54.1% men) in the SHIP-TREND and on 247 participants (mean age: 57...
December 14, 2018: Sleep
Wei Huang, Theodore M Johnson, Nancy G Kutner, Sean N Halpin, Paul Weiss, Patricia C Griffiths, Donald L Bliwise
OBJECTIVE: To evaluate real, as compared with sham, acupuncture in improving persistent sleep disturbance in veterans with mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD). METHODS: This sham-controlled randomized clinical trial at a US Department of Veterans Affairs Medical Center (2010-2015) included 60 veterans aged 24-55 years (mean of 40 years) with history of mTBI of at least 3 months and refractory sleep disturbance. Most of these participants (66...
December 11, 2018: Journal of Clinical Psychiatry
Sabra M Abbott, Roneil Malkani, Phyllis C Zee
Circadian rhythm disorders have been classically associated with disorders of abnormal timing of the sleep-wake cycle, however circadian dysfunction can play a role in a wide range of pathology, ranging from the increased risk for cardiometabolic disease and malignancy in shift workers, prompting the need for a new field focused on the larger concept of circadian medicine. The relationship between circadian disruption and human health is bidirectional, with changes in circadian amplitude often preceding the classical symptoms of neurodegenerative disorders...
December 14, 2018: European Journal of Neuroscience
Burak Arslan, Cem T Gezmis, Buğra Çetin, Serkan Gönültas, Ersin Gökmen, Okan Gürkan, Enver Ozdemir
OBJECTIVE: The aim of this study was to investigate the relationship between obstructive sleep apnea syndrome (OSAS) and lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH). METHODS: This multicenter study was performed on 122 male patients with dyspnea and/or sleep disorder. Patient characteristics were recorded. All patients underwent full-night polysomnography, and the apnea-hypopnea index (AHI) was calculated. LUTS were evaluated using the International Prostate Symptom Score (IPSS) and prostate volume was calculated by transabdominal ultrasonography...
December 12, 2018: Lower Urinary Tract Symptoms
Sameena Shah, Rabab Zehra Jafri, Khalil Mobin, Rabeea Mirza, Kashmira Nanji, Fatima Jahangir, Sufian Jawed Patel, Muzamil Shabana Ejaz, Iman Qaiser, Hira Iftikhar, Komal Aziz, Wajiha Khan, Humza S Maqbool, Hassaan Ahmed
BACKGROUND: Nocturnal enuresis (NE) is a common symptom in children worldwide. International Children's Continence Society (ICCS) defines enuresis as either mono-symptomatic, NE with lower urinary tract symptoms and NE with co-morbid conditions. The objectives of this study were to determine the frequencies and types of NE and associated symptoms and conditions in children aged 5 to 16 years based on ICCS criteria. METHODS: A multi-center cross sectional study was conducted between November 2012 and December 2013 in the primary care clinics of four hospitals in Karachi...
December 14, 2018: BMC Family Practice
Carrie E Mahoney, Andrew Cogswell, Igor J Koralnik, Thomas E Scammell
Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery about 20 years ago that narcolepsy is caused by selective loss of the neurons producing orexins (also known as hypocretins) sparked great advances in the field. Here, we review the current understanding of how orexin neurons regulate sleep-wake behaviour and the consequences of the loss of orexin neurons. We also summarize the developing evidence that narcolepsy is an autoimmune disorder that may be caused by a T cell-mediated attack on the orexin neurons and explain how these new perspectives can inform better therapeutic approaches...
December 13, 2018: Nature Reviews. Neuroscience
Terence E Donovan, Riccardo Marzola, Kevin R Murphy, David R Cagna, Frederick Eichmiller, James R McKee, James E Metz, Jean-Pierre Albouy, Mathias Troeltzsch
PROBLEM: There are countless numbers of scientific studies published in countless scientific journals on subjects related to restorative dentistry. PURPOSE: The purpose of this article is to review pertinent scientific studies published in 2017 on topics of interest to restorative dentists. METHODS AND MATERIALS: The authors, considered to be experts in their disciplines searched the scientific literature in 7 different areas (prosthodontics, periodontics, dental materials, occlusion and temporomandibular disorders, sleep-disordered breathing, oral medicine and oral and maxillofacial surgery and dental caries)...
December 2018: Journal of Prosthetic Dentistry
Masahiro Sano, Sayaka Sano, Hiromasa Kato, Ken Arakawa, Masaaki Arai
BACKGROUND: When mouth breathing becomes habitual, it can cause sleep disorders and abnormal maxillofacial growth, thus early detection of habitual mouth breathing is important. We created a questionnaire for early detection of habitual mouth breathing using a score based on a spectrum of factors found to be characteristic of mouth breathers. METHODS: First, a draft 50-question questionnaire was given to 101 random dental clinic patients, classified by dental professionals into habitual mouth breathers (n = 28) and nose breathers (n = 73)...
December 13, 2018: BMC Oral Health
Andreas Küffer, Laura D Straus, Aric A Prather, Sabra S Inslicht, Anne Richards, Judy K Shigenaga, Erin Madden, Thomas J Metzler, Thomas C Neylan, Aoife O'Donovan
BACKGROUND: Posttraumatic stress disorder (PTSD) is associated with disturbed sleep and elevated levels of pro-inflammatory cytokines, including interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Studies in animals and healthy humans have also shown that disrupted sleep elevates pro-inflammatory cytokines, including IL-6 and TNF-α. A better understanding of overnight cytokine levels and sleep might shed light on possible mechanisms for elevated inflammation in PTSD. Thus, we investigated overnight levels of IL-6 and TNF-α in individuals with and without PTSD while recording sleep polysomnography (PSG)...
December 5, 2018: Psychoneuroendocrinology
Danique R M Vlaskamp, Benjamin J Shaw, Rosemary Burgess, Davide Mei, Martino Montomoli, Han Xie, Candace T Myers, Mark F Bennett, Wenshu XiangWei, Danielle Williams, Saskia M Maas, Alice S Brooks, Grazia M S Mancini, Ingrid M B H van de Laar, Johanna M van Hagen, Tyson L Ware, Richard I Webster, Stephen Malone, Samuel F Berkovic, Renate M Kalnins, Federico Sicca, G Christoph Korenke, Conny M A van Ravenswaaij-Arts, Michael S Hildebrand, Heather C Mefford, Yuwu Jiang, Renzo Guerrini, Ingrid E Scheffer
OBJECTIVE: To delineate the epileptology, a key part of the SYNGAP1 phenotypic spectrum, in a large patient cohort. METHODS: Patients were recruited via investigators' practices or social media. We included patients with (likely) pathogenic SYNGAP1 variants or chromosome 6p21.32 microdeletions incorporating SYNGAP1 . We analyzed patients' phenotypes using a standardized epilepsy questionnaire, medical records, EEG, MRI, and seizure videos. RESULTS: We included 57 patients (53% male, median age 8 years) with SYNGAP1 mutations (n = 53) or microdeletions (n = 4)...
December 12, 2018: Neurology
Hung-Chi Lu, Harvey Pollack, John J Lefante, Alea A Mills, Di Tian
Sleep abnormalities are common among children with neurodevelopmental disorders. The human chr16p11.2 microdeletion is associated with a range of neurological and neurobehavioral abnormalities. Previous studies of a mouse model of human chr16p11.2 microdeletion (chr16p11.2df/+) have demonstrated pathophysiological changes at the synapses in the hippocampus and striatum; however, the impact of this genetic abnormality on system level brain functions, such as sleep and neural oscillation, has not been adequately investigated...
December 12, 2018: Sleep
Jared M Saletin, Stephanie Jackvony, Katherina A Rodriguez, Daniel P Dickstein
Study Objectives: Sleep disruption is common in attention-deficit-hyperactivity-disorder (ADHD). Likewise, deficits in attention are a hallmark of sleep deprivation in healthy individuals. Whether ADHD and sleep deprivation modulate common, or disparate, neural systems is unknown. No study has yet utilized fMRI to investigate sleep loss in ADHD. We address this gap by performing a novel meta-analysis to compare patterns of fMRI activation during sleep deprivation and ADHD. Methods: We performed a coordinate-based activation-likelihood-estimate (ALE) meta-analysis using the GingerALE software...
December 12, 2018: Sleep
Gil Bar-Sela, Dina Tauber, Inbal Mitnik, Hedva Sheinman-Yuffe, Tatiana Bishara-Frolova, Judith Aharon-Peretz
OBJECTIVES: In patients with cancer, the use of medical cannabis has increased significantly during the recent years. There is evidence that cannabis consumption may affect cognitive performance; however, this potential effect has not been investigated prospectively in patients with cancer to date. We aimed to evaluate the effect of cannabis consumption on cognitive abilities as well as on symptom relief in patients with cancer during chemotherapy treatment. PATIENTS AND METHODS: A prospective study was carried out on a group of 17 patients on cannabis treatment (case) who were compared with 17 patients not on cannabis treatment (control)...
January 2019: Anti-cancer Drugs
Aikaterini Lavrentaki, Asad Ali, Brendan Cooper, Abd Tahrani
Obstructive sleep apnoea (OSA) is a common disorder that is associated with serious co-morbidities with a negative impact on quality of life, life expectancy and health costs. As OSA is related to obesity and is associated with sleep disruption, increased inflammation and oxidative stress, it is not surprising that OSA has an impact on the secretion of multiple hormones and is implicated in the development of many endocrine conditions. On the other hand, many endocrine conditions that can affect obesity and/or upper airways anatomy and stability have been implicated in the development or worsening of OSA...
December 1, 2018: European Journal of Endocrinology
Kathleen Ries Merikangas, Joel Swendsen, Ian B Hickie, Lihong Cui, Haochang Shou, Alison K Merikangas, Jihui Zhang, Femke Lamers, Ciprian Crainiceanu, Nora D Volkow, Vadim Zipunnikov
Importance: Biologic systems involved in the regulation of motor activity are intricately linked with other homeostatic systems such as sleep, feeding behavior, energy, and mood. Mobile monitoring technology (eg, actigraphy and ecological momentary assessment devices) allows the assessment of these multiple systems in real time. However, most clinical studies of mental disorders that use mobile devices have not focused on the dynamic associations between these systems. Objectives: To examine the directional associations among motor activity, energy, mood, and sleep using mobile monitoring in a community-identified sample, and to evaluate whether these within-day associations differ between people with a history of bipolar or other mood disorders and controls without mood disorders...
December 12, 2018: JAMA Psychiatry
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