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https://www.readbyqxmd.com/read/30336152/enhancing-endogenous-adenosine-a-2a-receptor-signaling-induces-slow-wave-sleep-without-affecting-body-temperature-and-cardiovascular-function
#1
Mustafa Korkutata, Tsuyoshi Saitoh, Yoan Cherasse, Shuji Ioka, Feng Duo, Rujie Qin, Nobuyuki Murakoshi, Shinya Fujii, Xuzhao Zhou, Fumihiro Sugiyama, Jiang-Fan Chen, Hidetoshi Kumagai, Hiroshi Nagase, Michael Lazarus
Insomnia is one of the most common sleep problems with an estimated prevalence of 10%-15% in the general population. Although adenosine A2A receptor (A2A R) agonists strongly induce sleep, their cardiovascular effects preclude their use in treating sleep disorders. Enhancing endogenous A2A R signaling, however, may be an alternative strategy for treating insomnia, because adenosine levels in the brain accumulate during wakefulness. In the present study, we found that 3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid, denoted A2A R positive allosteric modulator (PAM)-1, enhanced adenosine signaling at the A2A R and induced slow wave sleep (SWS) without affecting body temperature in wild-type male mice after intraperitoneal administration, whereas the SWS-inducing effect of this benzoic acid derivative was abolished in A2A R KO mice...
October 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/30335476/obesity-and-sleep-disturbance-the-chicken-or-the-egg
#2
Giovanna Muscogiuri, Luigi Barrea, Giuseppe Annunziata, Carolina Di Somma, Daniela Laudisio, Annamaria Colao, Silvia Savastano
Epidemiological studies suggested an association between obesity and sleep disturbances. Obstructive sleep apnea is the most prevalent type of obesity-related sleep disorder that lead to an increased risk for numerous chronic health conditions. In addition the increased visceral adipose tissue might be responsible for the secretion of inflammatory cytokines that could contribute to alter the sleep-wake rhythm. Unhealthy food characterized by high consumption of fat and carbohydrate seems to negatively influence the quality of sleep while diet rich of fiber is associated to more restorative and deeper sleep...
October 18, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/30335080/-non-motor-disorders-in-patients-with-muscular-dystonia
#3
N I Salouchina, M R Nodel, V A Tolmacheva
Non-motor disturbances represented by sensory, affective, obsessive-compulsive disorders, cognitive dysfunction, sleep disturbances are often found in patients with dystonia and have a negative impact on their quality of life. The prevalence of sensory and affective disorders and sleep disturbances is above 50% in patients with cervical dystonia and is 25% in patients with blepharospasm, writing spasm; cognitive dysfunction is found in more than 25% of patients with focal dystonia. The relationship of non-motor, in particular psychiatric disorders, with the impairment of social and everyday life and worsening of quality of life in whole was shown...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/30335070/-dose-dependent-effects-of-cortexin-in-chronic-cerebral-ischemia-results-of-a-multicenter-randomized-controlled-study
#4
A I Fedin, G N Belskaya, O V Kurushina, V V Kovalchuk, E V Starych, L V Chichanovskaya, O A Baranova
AIM: To study an effect of cortexin on neurological symptoms and oxidative stress as part of the ischemic cascade in chronic cerebral ischemia (CCI), I-II stages. MATERIAL AND METHODS: The multicenter randomized controlled study included 189 patients with CCI, 42 (22.2%) men and 147 (77.8%) women, mean age 64.3±0.5 years. Patients were randomized into three groups. Group 1 received intramuscular injection of 20 mg of cortexin, group 2 received 10 mg of cortexin; group 3 received basic treatment only...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/30334862/poststroke-sleep-disorders-an-executive-summary
#5
Da-In Park, Smi Choi-Kwon
BACKGROUND: Poststroke sleep disorders (PSSDs) are common manifestations that may lead to adverse outcomes that pose a negative impact on the daily lives of stroke survivors. However, PSSD is poorly understood in terms of etiology, assessment, treatment, and nursing management. The purpose of this executive summary is to provide an overview to broaden our understanding of PSSDs. METHOD: The electronic databases EMBASE, PubMed, CINAHL, Cochrane Library, and Google Scholar were searched to identify any available relevant studies...
October 16, 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/30334487/-investigation-of-sleep-and-fatigue-in-patients-with-cancer
#6
Anna Klaudia Bollmann, Balázs Fábián, Judit Molnár
INTRODUCTION: The diagnosis of cancer elicits greater distress than any other diagnosis. The prevalence of psychological difficulties is high in cancer, and resources of the medical staff are limited. The development of efficient screening measures is therefore of utmost importance. Sleep is vital to all psychological functioning and poor sleep is a known problem in cancer. AIM: The main goal of the present study was testing of visual analogue scales assessing sleep quality and fatigue...
October 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/30333465/a-clinical-efficacy-experience-of-lacosamide-on-sleep-quality-in-patients-with-nocturnal-frontal-lobe-epilepsy-nfle
#7
Marilena Mangiardi, Guido Alfano
BACKGROUND: Nocturnal frontal lobe epilepsy (NFLE) is a focal epilepsy with seizures arising mainly during sleep and characterized by complex motor behavior or sustained dystonic posturing. First described in 1981, it was considered a motor disorder of sleep and was indicated as nocturnal paroxysmal dystonia (NPD). The debated on epileptic origin of this condition was demonstrated in 1990 and the term NFLE was introduced. Since then it has been demonstrated that the heterogeneous aspects of morpheic seizures were responsive to antiepileptic drugs (AED's) with sodium blocking action mechanism, especially the carbamazepine (CBZ)...
October 8, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30332331/neuroscience-and-greek-mythology
#8
Ioannis Karakis
This article highlights the major reflections of ancient Greek mythology in modern neuroscience. An analysis of ancient Greek texts and medical literature using the MeSH term mythology was performed to identify mythological references pertaining to neuroscience. The findings are discussed in relation to etymology, early conceptualization of the nervous system structure and function, incipient characterization of neuropsychiatric disease, and philosophical stance to the practice of medicine in ancient Greece...
October 17, 2018: Journal of the History of the Neurosciences
https://www.readbyqxmd.com/read/30328968/prevalence-of-and-pathways-to-benzodiazepine-use-in-brazil-the-role-of-depression-sleep-and-sedentary-lifestyle
#9
Clarice S Madruga, Thales L Paim, Hamer N Palhares, Andre C Miguel, Luciana T S Massaro, Raul Caetano, Ronaldo R Laranjeira
OBJECTIVE: This study aimed to determine the prevalence of benzodiazepine (BZD) use in Brazil and to investigate the direct and indirect effects of alcohol consumption, sedentary lifestyle (SL), depressive symptoms (DS), and sleep dissatisfaction (SD) on BZD use. METHODS: The Second Brazilian Alcohol and Drugs Survey (II BNADS) used stratified cluster probabilistic sampling to select 4,607 individuals aged 14 years and older from the Brazilian household population...
October 11, 2018: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/30328684/mathematical-modeling-of-circadian-rhythms
#10
REVIEW
Ameneh Asgari-Targhi, Elizabeth B Klerman
Circadian rhythms are endogenous ~24-hr oscillations usually entrained to daily environmental cycles of light/dark. Many biological processes and physiological functions including mammalian body temperature, the cell cycle, sleep/wake cycles, neurobehavioral performance, and a wide range of diseases including metabolic, cardiovascular, and psychiatric disorders are impacted by these rhythms. Circadian clocks are present within individual cells and at tissue and organismal levels as emergent properties from the interaction of cellular oscillators...
October 17, 2018: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/30328330/hemodynamic-autonomic-and-vascular-function-changes-after-sleep-deprivation-for-24-28-and-32-hours-in-healthy-men
#11
Joanna Słomko, Monika Zawadka-Kunikowska, Mariusz Kozakiewicz, Jacek J Klawe, Małgorzata Tafil-Klawe, Julia L Newton, Paweł Zalewski
This study aimed to analyze the impact of sleep deprivation (SD) on cardiac, hemodynamic, and endothelial parameters and to determine whether these are sustained with increased periods of SD. The study included 60 healthy men (mean: age 31.2±6.3 years; body mass index 24.6±2.6 kg/m²). Hemodynamic parameters, parameters of myocardial contractility, spectral analysis of heart rate (HR) and blood pressure (BP) variability, and the sensitivity of arterial baroreflex function were evaluated. Biochemical tests were performed to assess L-arginine (L-Arg) and asymmetric dimethylarginine (ADMA) levels in reflection of endothelial nitric oxide synthase ability...
November 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/30328223/treating-depression-with-adjunctive-antipsychotics
#12
REVIEW
Roger Mulder, Amber Hamilton, Lauren Irwin, Philip Boyce, Grace Morris, Richard J Porter, Gin S Malhi
OBJECTIVES: To evaluate the efficacy and safety of using adjunctive antipsychotics in patients with major depressive disorder. METHOD: Studies published since the last Cochrane review conducted in 2010 were identified via a literature search of recognised databases, using the keywords "adjunct*", "augment*", "antipsychotic" and "depression", and systematically evaluated. A targeted review of relevant guidelines was undertaken...
November 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/30328132/preliminary-evidence-that-vortioxetine-may-improve-sleep-quality-in-depressed-patients-with-insomnia-a-retrospective-questionnaire-analysis
#13
C Liguori, L Ferini-Strambi, F Izzi, L Mari, N Manfredi, A D'Elia, N B Mercuri, F Placidi
Insomnia is a frequent symptom in depressed patients. It can present with difficulty in initiating and/or maintaining sleep. We retrospectively evaluated a group of 15 patients affected by major depressive disorder (MDD) and complaining for insomnia, who started Vortioxetine (VOR) treatment for their depressive symptoms. The following questionnaires were captured at baseline and follow-up: Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and Beck Depression Inventory (BDI). PSQI total score significantly decreased between baseline and follow-up (p<0...
October 16, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/30328032/autonomic-dysfunction-in-sleep-disorders-introduction-to-the-series
#14
EDITORIAL
Jose-Alberto Palma
No abstract text is available yet for this article.
October 16, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30327397/scoping-review-of-systematic-reviews-of-complementary-medicine-for-musculoskeletal-and-mental-health-conditions
#15
Ava Lorenc, Gene Feder, Hugh MacPherson, Paul Little, Stewart W Mercer, Deborah Sharp
OBJECTIVE: To identify potentially effective complementary approaches for musculoskeletal (MSK)-mental health (MH) comorbidity, by synthesising evidence on effectiveness, cost-effectiveness and safety from systematic reviews (SRs). DESIGN: Scoping review of SRs. METHODS: We searched literature databases, registries and reference lists, and contacted key authors and professional organisations to identify SRs of randomised controlled trials for complementary medicine for MSK or MH...
October 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/30326812/-narcolepsy-and-other-central-disorders-of-hypersomnolence
#16
Johannes Mathis
Narcolepsy and Other 'Central Disorders of Hypersomnolence' Abstract. 'Excessive daytime sleepiness', 'hypersomnia' in the sense of prolonged sleep need, 'tiredness' or 'fatigue' are frequent complaints in primary care, requiring a careful separation in view of a correct diagnostic. After exclusion of various internistic and neurologic causes by clinical and laboratory investigations and after exclusion of sleep apnoea syndrome or other causes of disturbed sleep by polysomnography, the ambiguous group of 'Central Disorders of Hypersomnolence' remains, including narcolepsy with and without cataplexy, idiopathic hypersomnia, and non-organic hypersomnia...
2018: Praxis
https://www.readbyqxmd.com/read/30326346/borderline-personality-disorder-traits-and-suicide-risk-the-mediating-role-of-insomnia-and-nightmares
#17
Hilary L DeShong, Raymond P Tucker
BACKGROUND: Borderline personality disorder (BPD) is associated with high rates of suicide risk and problems related to sleep, including insomnia and nightmares. The purpose of the current study was to assess the potential indirect effect of BPD traits on suicide risk through both/either insomnia and nightmares. METHODS: Participants (N = 281) were recruited via Amazon's Mechanical Turk to complete the study remotely online. Participants completed measures of BPD traits and symptoms, suicide risk (history of suicidal thoughts and behaviors), insomnia symptoms, and distress and impairment related to nightmares...
October 9, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/30325486/hypertension-and-atrial-fibrillation-what-is-the-prevalence-of-obstructive-sleep-apnea-syndrome
#18
Afef Ben Halima, Samira Aouadi, Dorra Bejjar, Lobna Laroussi, Marouène Boukhris, Leila Gharbi, Faouzi Addad, Salem Kachboura
INTRODUCTION: Obstructive sleep apnea-hypopnea syndrome (OSAS) and cardiovascular disease are public health problems. The objective of our study was to evaluate the frequency of OSAS in patients with hypertension and atrial fibrillation (AF) and to investigate the factors associated with OSAS in this population. METHODS: It's a cross-sectional study including 73patients with hypertension and AF. All patients underwent a respiratory polygraphy. RESULTS: Seventy-Threepatients were included (57 women)...
March 2018: La Tunisie Médicale
https://www.readbyqxmd.com/read/30324875/perioperative-heart-brain-axis-protection-in-obese-surgical-patients-the-nutrigenomic-approach
#19
Jacopo Agrimi, Carlotta Baroni, Ekene Anakor, Vincenzo Lionetti
The number of obese patients undergoing cardiac and non cardiac surgery is rapidly increasing because they are more prone to concomitant diseases, such as diabetes, thrombosis, sleep-disordered breathing, cardiovascular and cerebrovascular diseases. Even if guidelines are already available to manage anesthesia and surgery of obese patients, the assessment of the perioperative morbidity and mortality from heart and brain disorders in morbidly obese surgical patients will be challenging in the next years. The present review will recapitulate the new mechanisms underlying the heart-brain axis vulnerability during the perioperative period in morbidly obese patients...
October 15, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/30324809/content-and-psychometric-evaluations-of-questionnaires-for-assessing-physical-function-in-people-with-low-back-disorders-a-systematic-review-of-the-literature
#20
Birgitta Wiitavaara, Marina Heiden
PURPOSE: The purpose was to investigate how physical function is assessed in people with musculoskeletal disorders in the low back. Specifically: Which questionnaires are used to assess physical function in people with musculoskeletal disorders in the low back? What aspects of physical function do those questionnaires measure? What are the measurement properties of the questionnaires? MATERIALS AND METHODS: A systematic review was performed to identify questionnaires and psychometric evaluations of them...
October 16, 2018: Disability and Rehabilitation
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