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Acute And Kidney And Disease

Karel Lábr, Jindřich Špinar, Jiří Pařenica, Lenka Špinarová, Filip Málek, Monika Špinarová, Ondřej Ludka, Jiří Jarkovský, Klára Benešová, Monika Goldbergová-Pávková, Růžena Lábrová
BACKGROUND/AIMS: The rate of incidence and prevalence of acute kidney injury is increasing due to an increased number of patients with heart failure. Therefore it is very pertinent to early detect the level of renal injuries and to make necessary heart failure predictions. Thus the aim of this study is to determine renal functions and prognosis stratification in chronic heart failure patients and importance of Neutrophil Gelatinase-Associated Lipocalin (NGAL), an early diagnostic marker of acute kidney injury, as well as stratification of cardiovascular risk in heart failure patients...
December 7, 2018: Kidney & Blood Pressure Research
Holly L Hutton, Maliha A Alikhan, A Richard Kitching
Inflammasomes influence a diverse range of kidney disease, including acute and chronic kidney diseases, and those mediated by innate and adaptive immunity. Both IL-18 and in particular IL-1β are validated therapeutic targets in several kidney diseases. In addition to leukocyte-derived inflammasomes, renal tissue cells express functional inflammasome components. Furthermore, a range of endogenous substances that directly activate inflammasomes also mediate kidney injury. Many of the functional studies have focussed on the NLRP3 inflammasome, and there is also evidence for the involvement of other inflammasomes in some conditions...
2018: Experientia. Supplementum
Mahboobeh Ghoochani, Mohammad Hadi Dehghani, Noushin Rastkari, Ramin Nabizadeh Nodehi, Masud Yunesian, Alireza Mesdaghinia, Anahita Houshiarrad, Maryam Saraei
Acute and chronic exposure to cadmium can cause numerous health effects including poisoning, as well as, bone, liver, and kidney diseases. Cadmium competes with iron absorption in blood and can induce anemia. Cadmium body burden can be measured through urine and blood samples. Urine reflects chronic and blood indicates recent and cumulative exposures to cadmium. Dietary is considered as the main source of exposure to cadmium in non-smoking general population. The study was conducted to determine cadmium level in blood, urine, and in diet of 120 non-smoking adults in Tehran...
December 7, 2018: Biological Trace Element Research
Babawale Taslim Bello, Olalekan Ezekiel Ojo, Olapeju Funke Oguntunde, Adedotun Ademola Adegboye
Introduction: Late presentation, usually to the emergency centre (EC), is frequently reported among patients with chronic kidney disease (CKD) in resource-limited settings, and is known to be associated with poor outcomes. This study aims to describe the pattern of EC presentation of adults with CKD in Southwest Nigeria. Methods: This was a prospective observational study of 158 consecutively presenting CKD patients at the EC of two tertiary hospitals in Southwest Nigeria...
December 2018: African Journal of Emergency Medicine Revue Africaine de la Médecine D'urgence
Miori Tanaka, Yoshimi Kishimoto, Mizuho Sasaki, Akari Sato, Tomoyasu Kamiya, Kazuo Kondo, Kaoruko Iida
Excessive oxidative stress plays a critical role in the progression of various diseases. Recently, we showed that Terminalia bellirica (Gaertn.) Roxb. extract (TBE) inhibits inflammatory response and reactive oxygen species (ROS) production in THP-1 macrophages. However, molecular mechanisms underlying anti-inflammatory and antioxidant activities of TBE and its major polyphenolic compounds gallic acid (GA) and ellagic acid (EA) remain unclear. We found that TBE and GA attenuated LPS-induced inflammatory mediator expression, ROS production, and activation of mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF- κ B) in RAW 264 macrophages...
2018: Oxidative Medicine and Cellular Longevity
Luis Enrique García-Ortuño, Norma Araceli Bobadilla
There is ample evidence showing that acute kidney injury (AKI) increases the risk of developing chronic kidney disease (CKD). Although considerable efforts have been undertaken in recent years to elucidate the mechanisms responsible for the AKI to CKD transition, many questions remain to be answered. In this review, we address most of the latest studies elucidating the mechanisms involved in this transition. Based on recent studies, the consensus to date is that endothelial and proximal tubular epithelium injury along with the activation of inflammatory processes occurring after an AKI episode, not only establish a close interrelation but also trigger a series of signaling pathways that culminate in the generation of tubulointerstitial fibrosis and chronic hypoxia, which lead to the progressive deterioration of functional tissue...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
David E Janhofer, Chrisovalantis Lakhiani, Paul J Kim, Cameron Akbari, Iram Naz, Eshetu A Tefera, Christopher E Attinger, Karen Kim Evans
BACKGROUND: In patients with lower extremity wounds, free tissue transfer is often the last option before amputation, making it crucial to optimize preoperative planning in order to prevent flap breakdown. No consensus exists regarding preoperative vascular work ups before lower extremity free tissue transfer. Here we analyzed the utility of using arteriography for lower extremity free flap planning. METHODS: A retrospective review was performed of 57 patients who underwent lower extremity arteriography and 59 free flap operations for lower extremity wounds between November 2014 and August 2017...
November 26, 2018: Plastic and Reconstructive Surgery
Amit Bardia, Mabel Wai, Manuel L Fontes
PURPOSE OF REVIEW: Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are a relatively new class of drugs used in the management of diabetes mellitus. This review will highlight key pharmacologic characteristics of this class of drugs; discuss their potential role in management of patients with cardiac disease; and raise several perioperative concerns for anesthesiologists caring for patients on SGLT-2 inhibitors. RECENT FINDINGS: Recent trials have shown a strong mortality benefit in diabetic patients on SGLT 2 inhibitors especially in patients with a high cardiovascular burden...
December 6, 2018: Current Opinion in Anaesthesiology
Sriram Sriperumbuduri, Swapnil Hiremath
PURPOSE OF REVIEW: Strong epidemiological and pathologic evidence associates NSAIDs with kidney disease, both acute and chronic. Hence, the usage of NSAIDs has decreased in patients with, or at risk for, chronic kidney disease (CKD). Coupled with this has been a rise in use of opioids and other non-NSAID alternatives, which do come with significant, and underrecognized, risk of nonrenal adverse events. We review the literature to understand if this shift is appropriate or deleterious...
December 5, 2018: Current Opinion in Nephrology and Hypertension
Ashley A Liou, Brent M Skiver, Eric Yates, Paul Persad, David Meyer, Andrew M Farland, Michael V Rocco
Alemtuzumab, a humanized monoclonal antibody that targets CD52 antigens on lymphocytes and monocytes, has shown efficacy in preventing relapse in relapsing-remitting multiple sclerosis. Despite known severe (yet rare) renal side effects such as anti-glomerular basement membrane disease and membranous glomerulopathy, to our knowledge, alemtuzumab has never been documented to cause drug-induced thrombotic microangiopathy. We describe a 39-year-old woman with relapsing-remitting multiple sclerosis who developed acute kidney injury requiring renal replacement therapy after 1 dose of alemtuzumab, as well as microangiopathic hemolytic anemia and thrombocytopenia...
December 7, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Tomoko Fujii, Tosiya Sato, Shigehiko Uchino, Kent Doi, Taku Iwami, Takashi Kawamura
PURPOSE: Acute kidney injury (AKI) is common in the intensive care unit (ICU). Selected clinical studies have implied human atrial natriuretic peptide (hANP) improves renal function; however, the treatment effects for AKI are unclear. METHODS: A multicenter prospective observational study in 13 Japanese ICUs. The effects of hANP were estimated by the standardized mortality ratio weighted analyses of generalized linear models using propensity scores. The primary outcome was renal replacement therapy (RRT) or death in the ICU...
December 1, 2018: Journal of Critical Care
Pauline Erpicum, Laurent Weekers, Olivier Detry, Catherine Bonvoisin, Marie-Hélène Delbouille, Céline Grégoire, Etienne Baudoux, Alexandra Briquet, Chantal Lechanteur, Gianni Maggipinto, Joan Somja, Hans Pottel, Frédéric Baron, François Jouret, Yves Beguin
Mesenchymal stromal cells (MSCs) exhibit anti-inflammatory and immune-regulatory properties, and preclinical studies suggest a potential benefit in solid organ transplantation. We report on the 1-year follow-up of an open-label phase I-II trial of a single infusion of third-party MSC post-kidney transplantation, in addition to standard immunosuppression. Ten kidney transplant recipients from deceased donors received third-party bone marrow MSCs (∼2 × 106 /kg) on day 3 ± 2 post-transplant and were compared to 10 concurrent controls...
December 6, 2018: Kidney International
Andreas D Flouris, Petros C Dinas, Leonidas G Ioannou, Lars Nybo, George Havenith, Glen P Kenny, Tord Kjellstrom
BACKGROUND: Occupational heat strain (ie, the effect of environmental heat stress on the body) directly threatens workers' ability to live healthy and productive lives. We estimated the effects of occupational heat strain on workers' health and productivity outcomes. METHODS: Following PRISMA guidelines for this systematic review and meta-analysis, we searched PubMed and Embase from database inception to Feb 5, 2018, for relevant studies in any labour environment and at any level of occupational heat strain...
December 2018: The Lancet. Planetary health
Kevin T Barton, Aadil Kakajiwala, Dennis J Dietzen, Charles W Goss, Hongjie Gu, Vikas R Dharnidharka
Beta-2-microglobulin (B2M) is a marker of proximal tubular injury and glomerular filtration. Analyses using older/non-standardized definitions have shown low efficacy of B2M to predict acute kidney injury (AKI). We assessed if elevated levels of B2M would associate with either the diagnosis of AKI [under current Kidney Disease: Improving Global Outcomes (KDIGO) criteria] or recovery from AKI. We performed a retrospective study, including children who had urine B2M (uB2M) and/or serum B2M (sB2M) measured by immunoturbidimetry in our clinical laboratory between January 2011 and December 2015...
December 2018: Clinical Kidney Journal
Alexandre Favà, Xavier Fulladosa, Nuria Montero, Juliana Draibe, Joan Torras, Montse Gomà, Josep M Cruzado
Renal injury is a common complication in multiple myeloma (MM). In fact, as many as 10% of patients with MM develop dialysis-dependent acute kidney injury related to increased free light chain (FLC) production by a plasma cell clone. Myeloma cast nephropathy (MCN) is the most prevalent pathologic diagnosis associated with renal injury, followed by light chain deposition disease and light chain amyloidosis. Several FLC removal techniques have been explored to improve kidney disease in MM but their impact on renal clinical outcomes remains unclear...
December 2018: Clinical Kidney Journal
Dharmendra Bhadauria, Praveen Etta, Anand Chelappan, Mohan Gurjar, Anupma Kaul, Raj Kumar Sharma, Amit Gupta, Narayan Prasad, Rungmei S Marak, Manoj Jain, Aneesh Srivastava, Hira Lal
Background: Isolated renal mucormycosis (IRM) is a potentially fatal disease affecting immunocompromised hosts. IRM affecting apparently immunocompetent patients is rare, with few previous reports, mostly from India. We describe 10 cases of bilateral IRM with no underlying risk factors. Methods: We performed a retrospective analysis of cases of IRM from our hospital information system admitted between 2009 and 2016. We analyzed the data of this cohort of IRM, including epidemiological characteristics, clinical presentation, diagnostic procedures, treatment details and outcome...
December 2018: Clinical Kidney Journal
Cédric Pinier, Philippe Gatault, Maud François, Christelle Barbet, Hélène Longuet, Nolwenn Rabot, Johann Noble, Elodie Bailly, Matthias Buchler, Bénédicte Sautenet, Jean-Michel Halimi
Background: Renal patients with diabetes mellitus are at very high risk of death before and after chronic dialysis initiation. Risk factors for death in this population are not clearly identified. Methods: We performed a retrospective survival analysis in 861 patients with diabetes mellitus consecutively followed up in the 2000-13 period in a nephrology setting. Results: The mean age was 70  ±  10 years [men 65.2%; diabetes duration 13...
December 2018: Clinical Kidney Journal
Sorino Claudio, Scichilone Nicola, Pedone Claudio, Negri Stefano, Visca Dina, Spanevello Antonio
A significant interaction between kidneys and lungs has been shown in physiological and pathological conditions. The two organs can both be targets of the same systemic disease (eg., some vasculitides). Moreover, loss of normal function of either of them can induce direct and indirect dysregulation of the other one. Subjects suffering from COPD may have systemic inflammation, hypoxemia, endothelial dysfunction, increased sympathetic activation and increased aortic stiffness. As well as the exposure to nicotine, all the foresaid factors can induce a microvascular damage, albuminuria, and a worsening of renal function...
December 6, 2018: Journal of Nephrology
Toshitsugu Sugimoto, Daisuke Inoue, Masayuki Maehara, Ichiro Oikawa, Takashi Shigematsu, Yoshiki Nishizawa
Limited data are available on the safety and efficacy of anti-resorptive agents, particularly once-monthly bisphosphonates, for use in osteoporotic patients with chronic kidney disease (CKD). We conducted a post hoc analysis of data from a 12-month, randomized, double-blind, phase III study to evaluate the safety and efficacy of once-monthly risedronate (RIS-OM) 75 mg tablets in Japanese osteoporosis patients with mild-to-moderate CKD. Patients who received RIS-OM 75 mg were stratified by baseline estimated glomerular filtration rate (eGFR; ≥ 90, ≥ 60 to < 90, or ≥ 30 to < 60 mL/min/1...
December 6, 2018: Journal of Bone and Mineral Metabolism
Monica Verdoia, Patrizia Pergolini, Matteo Nardin, Roberta Rolla, Lucia Barbieri, Paolo Marino, Alessandro Carriero, Harry Suryapranata, Giuseppe De Luca
BACKGROUND: ADP-antagonists such as prasugrel have reduced but yet not overcome the phenomenon of high-on treatment platelet reactivity (HRPR), that has been shown to increase the rate of major cardiovascular events after an acute coronary syndrome (ACS) or percutaneous coronary intervention (PCI). However, the exact prevalence and the principal determinants of suboptimal platelet inhibition in patients treated with dual antiplatelet therapy (DAPT) with prasugrel have not been completely clarified and were therefore the aim of the present study...
December 3, 2018: Journal of Cardiology
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