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Acute And Kidney And Disease

S M Hosseini-Moghaddam, M Shokoohi, G Singh, S F Dufresne, A Boucher, A Jevnikar, G V R Prasad, A Shoker, D Kabbani, M Hebert, H Cardinal, I Houde, A Humar, D Kumar
Background: Pneumocystis pneumonia (PCP) is associated with morbidity and mortality in solid organ transplant (SOT) recipients. In this case-control study, we determined the association between post-transplant PCP and 3 variables: cytomegalovirus infection, allograft rejection and prophylaxis. Methods: Eight transplantation centers participated. For each case (SOT recipient with PCP), 3-5 controls (SOT recipients without PCP) were included. Controls were matched to the cases based on transplant center, type of allograft and date of transplantation (± 6 months)...
August 13, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Jonatan Barrera-Chimal, Leslie Rocha, Isabel Amador-Martínez, Rosalba Pérez-Villalva, Rafael González, Cesar Cortés-González, Norma Uribe, Victoria Ramírez, Nathan Berman, Gerardo Gamba, Norma A Bobadilla
Background: Acute kidney injury (AKI) is not as harmless as previously thought since it may lead to chronic kidney disease (CKD). Because most of the time ischemic AKI occurs unexpectedly, it is difficult to prevent its occurrence and there are no specific therapeutic approaches to prevent the AKI to CKD transition. We aimed to determine whether mineralocorticoid receptor blockade (MRB) in the first days after ischemia/reperfusion (IR) can prevent progression to CKD. Methods: Four groups of male Wistar rats were included: sham and three groups of bilateral renal ischemia for 45 min, one without treatment and the other two receiving spironolactone for 5 or 10 days, starting 24 h after IR...
August 9, 2018: Nephrology, Dialysis, Transplantation
Ouidad Zehou, Claire Leibler, Jean-Philippe Arnault, Johnny Sayegh, Henri Montaudié, Philippe Rémy, Denis Glotz, Carole Cordonnier, Ludovic Martin, Céleste Lebbé
Immune checkpoint inhibitors are new therapeutic options for metastatic melanoma, but little data is available in organ transplant recipient populations. Six French patients, 3 men and 3 women, mean age 66 years (range 44-74), all kidney transplant recipients, received ipilimumab (CTLA-4 inhibitor) for metastatic melanoma. At diagnosis of advanced melanoma, immunosuppressive therapy had been minimized in all but one. Adverse effects included one case of grade 1 diarrhea and one grade 1 pruritus. One patient had acute T-cell-mediated rejection confirmed by histology, after the first injection of ipilimumab...
August 14, 2018: American Journal of Transplantation
Kuan-Ting Wu, Chung-Yang Chen, Bradley Chen, Jun-Wen Wang, Po-Chun Lin, Shih-Hsiang Yen
Background: Etiology of acute kidney disease (AKD) after total knee arthroplasty (TKA) was considered as multifactorial. However, the role of early postoperative volume supplement in AKD rate has not been investigated. The purpose of this study was to evaluate the incidence and risk factors of AKD in patients with early volume supplement following TKA. Methods: This was a retrospective study with 458 patients who underwent unilateral TKA. All the patients received 6% tetrastarch, 7...
2018: BioMed Research International
John M Haynes, James N Selby, Isaiah Pl Abad, Teresa Vandekolk, Joan K Ho, Wai-Ling Lieuw, Katie Leach, Judith Savige, Sheetal Saini, Craig Fisher, Sharon Ricardo
Renal podocyte survival depends upon the dynamic regulation of a complex cell architecture that links glomerular basement membrane to integrins, ion channels and receptors. Alport syndrome is a heritable chronic kidney disease where mutations in α3, α4 or α5 collagen genes promote podocyte death. In rodent models of renal failure, activation of the calcium sensing receptor (CaSR) can protect podocytes from stress related death. In this study we assess CaSR function in podocyte-like cells from induced-pluripotent stem cells derived from two patients with Alport Syndrome (AS1 & AS2), a renal disease free individual (NHMC) and an immortalized podocyte-like (HIP) cell line...
August 13, 2018: Journal of Pharmacology and Experimental Therapeutics
Yu-Feng Lin, Shuei-Liong Lin, Tao-Min Huang, Shao-Yu Yang, Tai-Shuan Lai, Likwang Chen, Vin-Cent Wu, Tzong-Shinn Chu, Kwan-Dun Wu
OBJECTIVE: Acute kidney injury (AKI) is related to a high prevalence of insulin resistance. However, information is lacking on the sequelae of further metabolic change among AKI requiring dialysis in patients who could be weaned off dialysis (acute kidney disease [AKD]). RESEARCH DESIGN AND METHODS: Using the National Health Insurance Research Database from 2000 to 2010, with the exclusion of those with diabetes at the start, we identified 3,307 subjects with AKD and 9,921 matched control subjects from 963,037 hospitalized patients for the comparison of the outcomes, including new-onset diabetes and all-cause mortality...
August 13, 2018: Diabetes Care
Ahmed Ghallab, Ute Hofmann, Selahaddin Sezgin, Nachiket Vartak, Reham Hassan, Ayham Zaza, Patricio Godoy, Kai Markus Schneider, Georgia Guenther, Yasser A Ahmed, Aya A Abbas, Verena Keitel, Lars Kuepfer, Steven Dooley, Frank Lammert, Christian Trautwein, Michael Spiteller, Dirk Drasdo, Alan F Hofmann, Peter L M Jansen, Jan G Hengstler, Raymond Reif
Bile duct ligation (BDL) is an experimental procedure that mimics obstructive cholestatic disease. One of the early consequences of BDL in rodents are so-called 'bile infarcts' that correspond to Charcot-Gombault necrosis in human cholestasis. The mechanisms causing bile infarcts and their pathophysiological relevance are unclear. Therefore, intravital two-photon-based imaging of bile duct-ligated mice was performed with fluorescent bile salts (BS) and non-BS organic anion analogues. Key findings were followed-up by MALDI imaging, clinical chemistry, immunostaining, and gene expression analyses...
August 13, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Maxime Rossi, Sandrine Delbauve, Eric Wespes, Thierry Roumeguère, Oberdan Leo, Véronique Flamand, Alain Le Moine, Jean-Michel Hougardy
Acute kidney injury (AKI) is a major public health concern, which is contributing to serious hospital complications, chronic kidney disease (CKD) and even death. Renal ischemia-reperfusion injury (IRI) remains a leading cause of AKI. The stress-responsive enzyme, heme oxygenase-1 (HO-1) mediates protection against renal IRI and may be preventively induced using hemin prior to renal insult. This HO-1 induction pathway called hemin preconditioning is largely known to be effective. Therefore, HO-1 might be an interesting therapeutic target in case of predictable AKI (e...
August 9, 2018: Biochemical and Biophysical Research Communications
F Dewi, R J Egan, T Abdelrahman, C Morris, M J Stechman, W G Lewis
AIMS: Post-operative acute kidney injury (AKI) is a common and independent mortality risk factor carrying high clinical and economic cost. This study aimed to establish the incidence of AKI in patients undergoing emergency laparotomy (EL), to determine patients' risk profile and consequent mortality. METHODS: Consecutive 239 patients of median age 68 (IQR 51-76) years, undergoing EL in a UK tertiary hospital, were studied. Primary outcome measure was AKI and in-hospital operative mortality...
August 10, 2018: World Journal of Surgery
Daniele Roberto Giacobbe, Alessandra di Masi, Loris Leboffe, Valerio Del Bono, Marianna Rossi, Dario Cappiello, Erika Coppo, Anna Marchese, Annarita Casulli, Alessio Signori, Andrea Novelli, Katja Perrone, Luigi Principe, Alessandra Bandera, Luca Enrico Vender, Andrea Misin, Pierpaolo Occhilupo, Marcello Melone, Paolo Ascenzi, Andrea Gori, Roberto Luzzati, Claudio Viscoli, Stefano Di Bella
This study aimed to assess the predictors of acute kidney injury (AKI) during colistin therapy in a cohort of patients with bloodstream infections (BSI) due to colistin-susceptible Gram-negative bacteria, focusing on the role of serum albumin levels. The study consisted of two parts: (1) a multicentre retrospective clinical study to assess the predictors of AKI during colistin therapy, defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria; and (2) bioinformatic and biochemical characterization of the possible interaction between human serum albumin and colistin...
August 10, 2018: Scientific Reports
Bikrant Bihari Lal, Priti Vijay, Vikrant Sood, Rajeev Khanna, Seema Alam
No abstract text is available yet for this article.
August 8, 2018: Journal of Pediatric Gastroenterology and Nutrition
S J Klein, F Husain-Syed, C Karagiannidis, G F Lehner, K Singbartl, M Joannidis
Interactions between lung and kidney can significantly affect the course of acute diseases, a phenomenon that was first observed in the 1950s by describing pulmonary dysfunction in uremic patients. From animal experiments there is ample evidence for remote lung injury following acute kidney injury (AKI), with an increased risk for the development of pulmonary edema and acute respiratory distress syndrome (ARDS). Coincident ARDS and AKI are associated with higher rates of intubation and mechanical ventilation, significantly prolonged weaning from mechanical ventilation and increased mortality...
August 9, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
Hamid Mohamadlou, Anna Lynn-Palevsky, Christopher Barton, Uli Chettipally, Lisa Shieh, Jacob Calvert, Nicholas R Saber, Ritankar Das
Background: A major problem in treating acute kidney injury (AKI) is that clinical criteria for recognition are markers of established kidney damage or impaired function; treatment before such damage manifests is desirable. Clinicians could intervene during what may be a crucial stage for preventing permanent kidney injury if patients with incipient AKI and those at high risk of developing AKI could be identified. Objective: In this study, we evaluate a machine learning algorithm for early detection and prediction of AKI...
2018: Canadian Journal of Kidney Health and Disease
Carlos G Musso, Alejandrina Castañeda, María Giordani, Cesar Mombelli, Silvia Groppa, Nora Imperiali, Guillermo Rosa Diez
Kidney transplant patients (KTPs), and particularly those with advanced chronic kidney rejection, may be affected by opportunistic infections, metabolic alterations and vascular and oncologic diseases that promote clinical conditions that require a variety of treatments, the combinations of which may predispose them to hyponatremia. Salt and water imbalance can induce abnormalities in volemia and/or serum sodium depending on the nature of this alteration (increase or decrease), its absolute magnitude (mild or severe) and its relative magnitude (body sodium:water ratio)...
August 2018: Clinical Kidney Journal
Yemi Raheem Raji, Samuel Oluwole Ajayi, Adeyinka F Ademola, Taiwo Akeem Lawal, Omobolaji O Ayandipo, Tinuola Adigun, Babatunde Salako
Background: Acute kidney injury (AKI) is an underreported but major cause of morbidity and mortality among patients undergoing major surgical interventions in sub-Saharan Africa (SSA). Whereas AKI is often seen following major cardiac surgery in high-income countries, a similar spectrum of surgical diseases and interventions is not seen in developing countries. The impacts on surgical outcomes have also not been well characterized in SSA. This study aimed at identifying risk factors, incidence and determinants and short-term outcomes of AKI among patients undergoing major surgery...
August 2018: Clinical Kidney Journal
Yuxi Wang, Zhi Zhao, Weiqi Yang, Lin Li, Fengming Zhu, Guangchang Pei, Juan Yang, Han Zhu, Huzi Xu, Meng Wang, Qian Yang, Zhizhi Hu, Pengge Wang, Gang Xu, Rui Zeng, Ying Yao
Tamoxifen is used to activate tamoxifen-dependent Cre recombinase (CreER) to generate time- and tissue-specific genetically mutant mice. However, tamoxifen is also an active estrogen analogue that binds with higher affinity to estrogen receptors and exhibits anti-apoptosis, anti-inflammation, and antifibrotic properties. Renal ischemia reperfusion (I/R) injury is characterized by increased apoptosis and inflammation, so optimal utility of tamoxifen-inducible CreER genetic systems in I/R model is important. The purpose of this study was to optimize the tamoxifen dose and evaluate its safety and tolerability in the development of mouse I/R injury...
2018: American Journal of Translational Research
Luke Maxfield, Aurora Peck, Laura Bond Youngblood
We report a 66-year-old man with a history of congestive heart failure, atrial fibrillation on warfarin therapy and chronic kidney disease that presented with acute dyspnoea. He had multiple palpable purpuric lesions on his bilateral lower extremities. Laboratory findings supported acute anaemia with no obvious bleeding source, supratherapeutic international normalised ratio and acute on chronic kidney injury. Oesophogastroduodenoscopy and colonoscopy initially suggested ischaemic colitis. The patient's legs were treated symptomatically with topical steroids...
August 9, 2018: BMJ Case Reports
Gennaro Giustino, Roxana Mehran, Patrick W Serruys, Joseph F Sabik, Milan Milojevic, Charles A Simonton, John D Puskas, David E Kandzari, Marie-Claude Morice, David P Taggart, Anthony H Gershlick, Philippe Généreux, Zixuan Zhang, Thomas McAndrew, Björn Redfors, Michael Ragosta, Irving L Kron, Ovidiu Dressler, Martin B Leon, Stuart J Pocock, Ori Ben-Yehuda, Arie Pieter Kappetein, Gregg W Stone
BACKGROUND: The optimal revascularization strategy for patients with left main coronary artery disease (LMCAD) and chronic kidney disease (CKD) remains unclear. OBJECTIVES: This study investigated the comparative effectiveness of percutaneous coronary intervention (PCI) versus coronary artery bypass graft (CABG) surgery in patients with LMCAD and low or intermediate anatomical complexity according to baseline renal function from the multicenter randomized EXCEL (Evaluation of XIENCE Versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) trial...
August 14, 2018: Journal of the American College of Cardiology
Nathan James Lanning, Calvin VanOpstall, Megan L Goodall, Jeffrey P MacKeigan, Brendan David Looyenga
Defects in vesicular trafficking underlie a wide variety of human diseases. Genetic disruption of leucine-rich repeat kinase 2 (LRRK2) in rodents results in epithelial vesicular trafficking errors that can also be induced by treatment of animals with LRRK2 kinase inhibitors. Here we demonstrate that defects in human renal cells lacking LRRK2 phenocopy those seen in the kidneys of Lrrk2 knockout mice, characterized by accumulation of intracellular waste vesicles and fragmentation of the Golgi apparatus. This phenotype can be recapitulated by knockdown of N-ethylmaleimide sensitive factor (NSF), which physically associates with LRRK2 in renal cells...
August 8, 2018: American Journal of Physiology. Renal Physiology
Jin Hyen Baek, Ayla Yalamanoglu, Ronald P Brown, David M Saylor, Richard A Malinauskas, Paul W Buehler
Plasma hemoglobin (Hb) is elevated in some hematologic disease states, during exposures to certain toxicants, and with the use of some medical devices. Exposure to free Hb can precipitate oxidative reactions within tissues and alter the normal physiological function of critical organ systems. As kidney structures can be highly sensitive to Hb exposures, we evaluated the acute dose dependent renal toxicologic response to purified Hb isolated from RBCs. Male Hartley guinea pigs (n = 5 per group) were dosed with 0...
July 31, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
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