keyword
https://read.qxmd.com/read/38536541/bone-marrow-mesenchymal-stem-cell-derived-exosomes-promote-the-recovery-of-spinal-cord-injury-and-inhibit-ferroptosis-by-inactivating-il-17-pathway
#1
JOURNAL ARTICLE
Wen Tang, Kai Zhao, Xiaobo Li, Xiaozhong Zhou, Peigen Liao
Mesenchymal stem cell (MSC)-derived exosomes are considered as alternative to cell therapy in various diseases. This study aimed to understand the effect of bone marrow MSC-derived exosomes (BMMSC-exos) on spinal cord injury (SCI) and to unveil its regulatory mechanism on ferroptosis. Exosomes were isolated from BMMSCs and the uptake of BMMSCs-exos by PC12 cells was determined using PKH67 staining. The effect of BMMSC-exos on SCI in rats was studied by evaluating pathological changes of spinal cord tissues, inflammatory cytokines, and ferroptosis-related proteins...
March 27, 2024: Journal of Molecular Neuroscience: MN
https://read.qxmd.com/read/38527680/chitin-a-versatile-biopolymer-based-functional-therapy-for-cartilage-regeneration
#2
JOURNAL ARTICLE
Huma Hameed, Mahtab Ahmad Khan, Ana Cláudia Paiva-Santos, Nelofer Ereej, Saleha Faheem
Chitin is the second most abundant biopolymer and its inherent biological characteristics make it ideal to use for tissue engineering. For many decades, its properties like non-toxicity, abundant availability, ease of modification, biodegradability, biocompatibility, and anti-microbial activity have made chitin an ideal biopolymer for drug delivery. Research studies have also shown many potential benefits of chitin in the formulation of functional therapy for cartilage regeneration. Chitin and its derivatives can be processed into 2D/3D scaffolds, hydrogels, films, exosomes, and nano-fibers, which make it a versatile and functional biopolymer in tissue engineering...
March 23, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38525237/intrauterine-injection-of-bioengineered-hydrogel-loaded-exosomes-derived-from-hucm-stem-cells-and-spermidine-prominently-augments-the-pregnancy-rate-in-thin-endometrium-rats
#3
JOURNAL ARTICLE
Xiuying Lin, Yanqiu Fang, Xuguang Mi, Jianhua Fu, Shiling Chen, Mengxue Wu, Ningyi Jin
The endometrium is essential to the development of embryos and pregnancy. Human umbilical cord mesenchymal stem cells (HUCMSCs) are promising stem cell sources. HUCMSCs self-renew quickly and are painless to collect. Spermidine is an inherent polyamine needed for cellular and molecular processes that regulate physiology and function. HUCMSCs and spermidine (SN) may heal intrauterine adhesions. HUCMSCs were investigated for endometrial repair in rats. Composite hydrogels are used for medical exosome implantation, including their materials, properties, and embedding procedures...
December 2024: Regenerative Therapy
https://read.qxmd.com/read/38524392/human-mesenchymal-stem-cell-derived-exosomes-promote-the-proliferation-and-melanogenesis-of-primary-melanocytes-by-attenuating-the-h-2-o-2-related-cytotoxicity-in-vitro
#4
JOURNAL ARTICLE
Yexiao Wang, Zibin He, Bingqin Luo, Hioteng Wong, Liangcai Wu, Hui Zhou
BACKGROUND: Mesenchymal stem cell-derived exosomes (MSC-Exo) have therapeutic potential. However, the impact of MSC-Exo on the survival and melanogenesis of human primary melanocytes following H2 O2 -induced damage has not been clarified. We therefore investigated the effects of MSC-Exo on the H2 O2 -affected survival of human primary melanocytes and their proliferation, apoptosis, senescence, and melanogenesis in vitro. METHODS: MSC-Exo were prepared from human MSCs by sequential centrifugations and characterized by Transmission Electron Microscopy, Western blot and Nanoparticle Tracking Analysis...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38523514/potential-druggability-of-mesenchymal-stem-stromal-cell-derived-exosomes
#5
JOURNAL ARTICLE
Fan Zhang, Leisheng Zhang, Hao Yu
Exosomes secreted by mesenchymal stem/stromal cells (MSC-Exos) are advantageous candidate sources for novel acellular therapy. Despite the current standards of good manufacturing practice (GMP), the deficiency of suitable quality-control methods and the difficulties in large-scale preparation largely restrict the development of therapeutic products and their clinical applications worldwide. Herein, we mainly focus on three dominating issues commonly encountered in exosomal GMP, including issues upstream of the cell culture process, downstream of the purification process, exosomes quality control, and the drug properties of exosomes and their druggability from a corporate perspective...
March 22, 2024: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/38521740/sequential-transplantation-of-exosomes-and-bmscs-pretreated-with-hypoxia-efficiently-facilitates-perforator-skin-flap-survival-area-in-rats
#6
JOURNAL ARTICLE
Jin-Ping Ding, Yan Sun, Bo Chen, Wen-Jiang Qian, Shi-Wei Bao, Hong-Yi Zhao
Bone marrow mesenchymal stem cells (BMSC) are promising candidates for the treatment of trans-territory perforator flap necrosis. However, the low retention and survival rate of engrafted BMSCs limit their therapeutic efficacy. Strategies either modifying BMSCs or alleviating the inflammatory environment may solve this problem. Thus, we aimed to explore the therapeutic efficacy of sequential transplantation of exosomes and hypoxia pretreated BMSCs on flap necrosis. After the perforator flap model was created, the exosomes derived from BMSCs were injected immediately into choke zone II followed by transplantation of hypoxia pretreated BMSCs on Day 2...
December 28, 2023: British Journal of Oral & Maxillofacial Surgery
https://read.qxmd.com/read/38520545/exosomes-in-renal-cell-carcinoma-challenges-and-opportunities
#7
REVIEW
Mahan Mohammadi, Kamran Mansouri, Pantea Mohammadi, Mehran Pournazari, Houshang Najafi
Renal cell carcinoma (RCC) is the most common type of kidney cancer that accounts for approximately 2-3% of adult malignancies. Among the primary treatment methods for this type of cancer are surgery and targeted treatment. Still, due to less than optimal effectiveness, there are problems such as advanced distant metastasis, delayed diagnosis, and drug resistance that continue to plague patients. In recent years, therapeutic advances have increased life expectancy and effective treatment in renal cell carcinoma patients...
March 23, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38518900/mesenchymal-stem-cell-derived-exosomes-promote-tissue-repair-injury-in-rats-with-liver-trauma-by-regulating-gut-microbiota-and-metabolism
#8
JOURNAL ARTICLE
Bo Yi, Juan Pan, Zhaoming Yang, Zemin Zhu, Yongkang Sun, Tao Guo, Zhijian Zhao
OBJECTIVE: The effects of mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-exos) on serum metabolites and intestinal microbiota in rats after liver trauma were discussed. METHODS: Adult Wistar Albino rats were assigned into control, model (liver trauma), MSCs, and MSC-exos groups (n = 6). The study examined changes in the inflammatory environment in liver tissues were analyzed by histological examination and analysis of macrophage phenotypes...
March 20, 2024: Molecular and Cellular Probes
https://read.qxmd.com/read/38516531/extracellular-vesicles-derived-from-mesenchymal-stem-cells-the-wine-in-hebe-s-hands-to-treat-skin-aging
#9
REVIEW
Qixiang Gui, Neng Ding, Zuochao Yao, Minjuan Wu, Ruifeng Fu, Yue Wang, Yunpeng Zhao, Lie Zhu
Owing to its constant exposure to the external environment and various stimuli, skin ranks among the organs most vulnerable to manifestations of aging. Preventing and delaying skin aging has become one of the prominent research subjects in recent years. Mesenchymal stem cells (MSCs) are multipotent stem cells derived from mesoderm with high self-renewal ability and multilineage differentiation potential. MSC-derived extracellular vesicles (MSC-EVs) are nanoscale biological vesicles that facilitate intercellular communication and regulate biological behavior...
March 2024: Precision Clinical Medicine
https://read.qxmd.com/read/38515611/thread-structural-microneedles-loaded-with-engineered-exosomes-for-annulus-fibrosus-repair-by-regulating-mitophagy-recovery-and-extracellular-matrix-homeostasis
#10
JOURNAL ARTICLE
Shaojun Hu, Meng Zhu, Hongyuan Xing, Yucheng Xue, Jun Li, Zhan Wang, Zhou Zhu, Miaojie Fang, Zilong Li, Jianbin Xu, Yong He, Ning Zhang
Low back pain is among the most grave public health concerns worldwide and the major clinical manifestation of intervertebral disc degeneration (IVDD). The destruction of annulus fibrosus (AF) is the primary cause of IVDD. A sustainable and stable treatment system for IVDD is lacking because of the special organizational structure and low nutrient supply of AF. We here found that IVDD results in the impaired mitochondrial function of AF tissue, and mitochondrial autophagy (mitophagy) plays a protective role in this process...
July 2024: Bioactive Materials
https://read.qxmd.com/read/38513992/plasma-exosomal-mir-30a-5p-inhibits-osteogenic-differentiation-of-bone-marrow-mesenchymal-stem-cells-from-a-chronic-unpredictable-mild-stress-induced-depression-rat-model
#11
JOURNAL ARTICLE
Boyu Tan, Xueyao Jiang, Li Chen, Rongsheng Wang, Hongyan Wei
With rising society stress, depression-induced osteoporosis is increasing. However, the mechanism involved is unclear. In this study, we explored the effect of plasma exosomal miRNAs on bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation in a chronic unpredictable mild stress (CUMS)-induced depression rat model. After 12 weeks of CUMS-induced depression, the pathological changes in the bone tissue and markers of osteogenic differentiation were tested by micro-computed tomography, hematoxylin-eosin staining, and quantitative real-time reverse transcription PCR (qRT-PCR)...
March 19, 2024: Molecular and Cellular Probes
https://read.qxmd.com/read/38512651/bmscs-derived-exosome-cish-alleviates-myocardial-infarction-by-inactivating-the-nf-%C3%AE%C2%BAb-pathway-to-stimulate-macrophage-m2-polarization
#12
JOURNAL ARTICLE
Minzhi Ouyang, Yang Yang, Guolong Yu, Jiling Zhao, Yi Peng
Current myocardial infarction (MI) treatments are suboptimal, necessitating deeper pathogenesis understanding of MI. This research explored how exosomes (Exo) derived from bone marrow mesenchymal stem cells (BMSCs) contribute to MI mitigation and their therapeutic potential. Isolated BMSCs was identified by microscope, flow cytometry, alizarin red and oil red O staining. Exo were identified by TEM, NTA and western blot. HE staining, masson staining, and cardiac function parameters were used to assess the cardiac function in MI mice...
March 21, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38512548/challenges-of-mesenchymal-stem-cells-in-the-clinical-treatment-of-covid-19
#13
REVIEW
Luping Li, Xiaoshuang Zhang, Yawen Wu, Cencan Xing, Hongwu Du
The 2019 coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has brought an enormous public health burden to the global society. The duration of the epidemic, the number of infected people, and the widespread of the epidemic are extremely rare in modern society. In the initial stage of infection, people generally show fever, cough, and dyspnea, which can lead to pneumonia, acute respiratory syndrome, kidney failure, and even death in severe cases. The strong infectivity and pathogenicity of SARS-CoV-2 make it more urgent to find an effective treatment...
March 21, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38509833/targeted-repair-of-spinal-cord-injury-based-on-mirna-124-3p-loaded-mesoporous-silica-camouflaged-by-stem-cell-membrane-modified-with-rabies-virus-glycoprotein
#14
JOURNAL ARTICLE
Xiangchuang Fan, Lusen Shi, Zimeng Yang, Yiwei Li, Chi Zhang, Baoshuai Bai, Lu Chen, Elzat Elham-Yilizati Yilihamu, Zhangyang Qi, Wenxiang Li, Peng Xiao, Mingshan Liu, Jichuan Qiu, Fan Yang, Ning Ran, Yifan Shang, Jiaxing Liu, Tehan Zhang, Xiaohong Kong, Hong Liu, Hengxing Zhou, Shiqing Feng
Spinal cord injury (SCI) has no effective treatment modalities. It faces a significant global therapeutical challenge, given its features of poor axon regeneration, progressive local inflammation, and inefficient systemic drug delivery due to the blood-spinal cord barrier (BSCB). To address these challenges, a new nano complex that achieves targeted drug delivery to the damaged spinal cord is proposed, which contains a mesoporous silica nanoparticle core loaded with microRNA and a cloaking layer of human umbilical cord mesenchymal stem cell membrane modified with rabies virus glycoprotein (RVG)...
March 21, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38509665/immunological-regulation-of-gut-tropic-immune-cells-by-extracellular-vesicles
#15
REVIEW
Yasunari Matsuzaka, Ryu Yashiro
The remarkable diversity of lymphocytes, essential components of the immune system, serves as an ingenious mechanism for maximizing the efficient utilization of limited host defense resources. While cell adhesion molecules, notably in gut-tropic T cells, play a central role in this mechanism, the counterbalancing molecular details have remained elusive. Conversely, we've uncovered the molecular pathways enabling extracellular vesicles secreted by lymphocytes to reach the gut's mucosal tissues, facilitating immunological regulation...
January 2024: Immunological Investigations
https://read.qxmd.com/read/38508525/regulatory-t-cell-derived-exosome-mediated-macrophages-polarization-for-osteogenic-differentiation-in-fracture-repair
#16
JOURNAL ARTICLE
Tingting Wu, Lulu Wang, Chen Jian, Chen Gao, Yajing Liu, Zhiwen Fu, Chen Shi
Refractory fracture presents an intractable challenge in trauma treatment. Selective polarization of macrophages as well as the recruitment of osteogenic precursor cells play key roles in osteogenic differentiation during fracture healing. Here we constructed regulatory T cell (Treg)-derived exosomes (Treg-Exo) for the treatment of fracture. The obtained exosomes displayed a spheroid shape with a hydrated particle size of approximately 130 nm. With further purification using CD39 and CD73 antibody-modified microfluidic chips, CD39 and CD73 specifically expressing exosomes were obtained...
March 18, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38505171/targeted-delivery-of-mesenchymal-stem-cell-derived-bioinspired-exosome-mimetic-nanovesicles-with-platelet-membrane-fusion-for-atherosclerotic-treatment
#17
JOURNAL ARTICLE
Yu Jiang, Miao Yu, Zhi-Feng Song, Zhi-Yao Wei, Ji Huang, Hai-Yan Qian
PURPOSE: Accumulating evidence indicates that mesenchymal stem cells (MSCs)-derived exosomes hold significant potential for the treatment of atherosclerosis. However, large-scale production and organ-specific targeting of exosomes are still challenges for further clinical applications. This study aims to explore the targeted efficiency and therapeutic potential of biomimetic platelet membrane-coated exosome-mimetic nanovesicles (P-ENVs) in atherosclerosis. METHODS: To produce exosome-mimetic nanovesicles (ENVs), MSCs were successively extruded through polycarbonate porous membranes...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38500663/extracellular-vesicles-as-a-new-frontier-of-diagnostic-biomarkers-in-osteosarcoma-diseases-a-bibliometric-and-visualized-study
#18
JOURNAL ARTICLE
Yanhong Pei, Yu Guo, Wei Wang, Boyang Wang, Fanwei Zeng, Qianyu Shi, Jiuhui Xu, Lei Guo, Chaowei Ding, Xiangpang Xie, Tingting Ren, Wei Guo
The use of liquid biopsy in cancer research has grown exponentially, offering potential for early detection, treatment stratification, and monitoring residual disease and recurrence. Exosomes, released by cancer cells, contain tumor-derived materials and are stable in biofluids, making them valuable biomarkers for clinical evaluation. Bibliometric research on osteosarcoma (OS) and exosome-derived diagnostic biomarkers is scarce. Therefore, we aimed to conduct a bibliometric evaluation of studies on OS and exosome-derived biomarkers...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38500415/exosomes-derived-from-bone-marrow-mesenchymal-stem-cells-alleviate-rheumatoid-arthritis-symptoms-via-shuttling-proteins
#19
JOURNAL ARTICLE
Lijun Wang, Fei Li, Liting Wang, Bingxing Wu, Min Du, Hua Xing, Shifeng Pan
Our prior investigations have evidenced that bone marrow mesenchymal stem cell (BMSC) therapy can significantly improve the outcomes of rheumatoid arthritis (RA). This study aims to conduct a comprehensive analysis of the proteomics between BMSCs and BMSCs-Exos, and to further elucidate the potential therapeutic effect of BMSCs-Exos on RA, so as to establish a theoretical framework for the prevention and therapy of BMSCs-Exos on RA. The 4D label-free LC-MS/MS technique was used for comparative proteomic analysis of BMSCs and BMSCs-Exos...
March 18, 2024: Journal of Proteome Research
https://read.qxmd.com/read/38499232/microglial-uptake-of-hadscs-exo-mitigates-neuroinflammation-in-ich
#20
JOURNAL ARTICLE
Lanqing Zhao, Jinwei Li
Intracerebral hemorrhage (ICH) is associated with secondary neuroinflammation, leading to severe central nervous system damage. Exosomes derived from human adipose-derived mesenchymal stem cells (hADSCs-Exo) have shown potential therapeutic effects in regulating inflammatory responses in ICH. This study aims to investigate the role of hADSCs-Exo in ICH and its underlying mechanism involving miRNA-mediated regulation of formyl peptide receptor 1 (FPR1). Flow cytometry was used to identify hADSCs and extract exosomes...
March 16, 2024: Cellular Signalling
keyword
keyword
160521
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.