Xiangchuang Fan, Lusen Shi, Zimeng Yang, Yiwei Li, Chi Zhang, Baoshuai Bai, Lu Chen, Elzat Elham-Yilizati Yilihamu, Zhangyang Qi, Wenxiang Li, Peng Xiao, Mingshan Liu, Jichuan Qiu, Fan Yang, Ning Ran, Yifan Shang, Jiaxing Liu, Tehan Zhang, Xiaohong Kong, Hong Liu, Hengxing Zhou, Shiqing Feng
Spinal cord injury (SCI) has no effective treatment modalities. It faces a significant global therapeutical challenge, given its features of poor axon regeneration, progressive local inflammation, and inefficient systemic drug delivery due to the blood-spinal cord barrier (BSCB). To address these challenges, a new nano complex that achieves targeted drug delivery to the damaged spinal cord is proposed, which contains a mesoporous silica nanoparticle core loaded with microRNA and a cloaking layer of human umbilical cord mesenchymal stem cell membrane modified with rabies virus glycoprotein (RVG)...
March 21, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)