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https://www.readbyqxmd.com/read/30517912/recognizing-common-skin-and-soft-tissue-infections-in-the-nephrology-clinic
#1
REVIEW
Karen M Van de Velde-Kossmann
Renal failure patients have an increased risk of infection, including skin and soft tissue infections. This increased susceptibility is multifactorial, due to the conditions causing the renal failure as well as complications of treatment and renal failure's innate effects on patient health. These infections have a significant impact on patient morbidity, increased hospital and procedural demands, and the cost of health care. Many renal failure patients are seen regularly by their nephrology clinic caregivers due to the need for frequent dialysis and transplant monitoring...
December 5, 2018: Blood Purification
https://www.readbyqxmd.com/read/30517906/haptic-information-provided-by-anchors-and-the-presence-of-cognitive-tasks-contribute-separately-to-reducing-postural-sway-in-young-adults
#2
Rosangela Alice Batistela, Alison Oates, Renato Moraes
BACKGROUND: Haptic information provided by the anchors reduces postural sway while standing upright. It is unclear whether this benefit would remain in the presence of cognitive tasks combined with a more challenging postural task. RESEARCH QUESTION: Our aim was to investigate the effects of the anchors and visual and auditory cognitive tasks on postural control in young adults in a challenging balancing task. METHODS: Twenty young adults stood upright on a balance beam with the central portion of each foot placed over the beam and feet at shoulder width without and with the use of the anchors in three cognitive conditions: control, visual Stroop task, and auditory digit-monitoring task...
November 28, 2018: Gait & Posture
https://www.readbyqxmd.com/read/30517675/return-to-duty-following-open-reduction-and-internal-fixation-of-unstable-ankle-fractures-in-the-active-duty-population
#3
John D Johnson, Laura A Chachula, Ryan J Bickley, Claude D Anderson, Paul M Ryan
Introduction: Literature on functional outcomes after ankle surgery is for the most part limited to return to sport studies. The purpose of this study was to determine occupational and functional outcomes following operative treatment of unstable ankle fractures in the active duty military population. Materials and Methods: All ankle fractures treated with open reduction internal fixation at a single institution from 2013 to 2015 were reviewed. Inclusion criteria included active duty personnel with a single-sided injury requiring operative management...
December 4, 2018: Military Medicine
https://www.readbyqxmd.com/read/30517549/diabetic-foot-ulcers-with-myiasis-a-potential-route-for-resistance-gene-dissemination-for-enterococci
#4
Felipe Tavares Rodrigues, Valéria Magalhães Aguiar, Claudia Soares Lessa
No abstract text is available yet for this article.
November 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/30517431/effects-of-nursing-care-on-patients-in-an-educational-program-for-prevention-of-diabetic-foot
#5
Suzana Fiore Scain, Elenara Franzen, Vânia Naomi Hirakata
OBJECTIVES: Identify in patients with type 2 diabetes what changes in the feet would be associated with demographic, clinical, biochemical and treatment characteristics and which would increase the risk of mortality. METHODS: Retrospective longitudinal study evaluating the alterations in feet of outpatients attended at a nursing visit. Data from the clinical history and foot exam were collected from 918 medical records of a convenience sample. RESULTS: At 10 years, the cumulative mortality attributable to peripheral polyneuropathy was 44...
November 29, 2018: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/30517410/degree-of-risk-for-foot-ulcer-due-to-diabetes-nursing-assessment
#6
Maria do Livramento Saraiva Lucoveis, Mônica Antar Gamba, Maria Angela Boccara de Paula, Ana Beatriz Pinto da Silva Morita
OBJECTIVE: To classify the level of risk for foot ulcers in people with diabetes mellitus and identify their main predictive risk factors. METHOD: Exploratory, descriptive study, in which patients were assessed in a municipal ambulatory of São Paulo through nursing consultation, following the guidelines of the International Consensus on the Diabetic Foot. Data were descriptively analyzed. RESULTS: The analyzed population was composed of 50 longevous and retired people, with household income of up to two minimum wages, with dermato-neurofunctional risk factors and unfavorable clinical indicators, and 66% had Risk 1; 16% Risk 2; 6% Risk 3 and 12% Risk 4...
November 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/30517288/effects-of-nanoparticles-of-hydroxy-aluminum-phthalocyanine-on-markers-of-liver-injury-and-glucose-metabolism-in-diabetic-mice
#7
M A B Melo, W Caetano, E L Oliveira, P M Barbosa, A L B Rando, M M D Pedrosa, V A F Godoi
Photodynamic therapy, by reducing pain and inflammation and promoting the proliferation of healthy cells, can be used to treat recurrent lesions, such as diabetic foot ulcers. Studies using the photosensitizer phthalocyanine, together with the nanostructured copolymeric matrix of Pluronic® and Carbopol® for the treatment of diabetic foot ulcers and leishmaniosis lesions, are showing promising outcomes. Despite their topical or subcutaneous administration, these molecules are absorbed and their systemic effects are unknown...
December 3, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30517158/cranio-caudal-and-medio-lateral-navicular-translation-are-representative-surrogate-measures-of-foot-function-in-asymptomatic-adults-during-walking
#8
Patric Eichelberger, Johannes Pohl, Theo Jaspers, Matteo Ferraro, Fabian Krause, Heiner Baur
INTRODUCTION: The translation of the navicular bone is thought to be a representative surrogate measure to assess foot pronation and hence foot function; however, it is not known how it is related to multi-segment foot kinematics. METHODS: Cranio-caudal (NCC) and medio-lateral (NML) navicular translation and multi-segment foot kinematics from the Oxford Foot Model (OFM) were simultaneously assessed during the stance phase of walking in 20 healthy adults. Relationships to forefoot to hindfoot (FFtoHF), hindfoot to tibia (HFtoTBA) and global hindfoot (HFL) motion were explored by cross-correlations at zero phase shift...
2018: PloS One
https://www.readbyqxmd.com/read/30517140/traces-of-history-conserved-over-600-years-in-the-geographic-distribution-of-genetic-variants-of-an-rna-virus-bovine-viral-diarrhea-virus-in-switzerland
#9
Hanspeter Stalder, Claudia Bachofen, Matthias Schweizer, Reto Zanoni, Dominik Sauerländer, Ernst Peterhans
The first records of smallpox and rabies date back thousands of years and foot-and-mouth disease in cattle was described in the 16th century. These diseases stood out by their distinct signs, dramatic way of transmission from rabid dogs to humans, and sudden appearance in cattle herds. By contrast, infectious diseases that show variable signs and affect few individuals were identified only much later. Bovine viral diarrhea (BVD), endemic in cattle worldwide, was first described in 1946, together with the eponymous RNA virus as its cause...
2018: PloS One
https://www.readbyqxmd.com/read/30517028/an-updated-normative-data-set-from-the-autonomic-reflex-screen-representative-of-southwestern-ontario
#10
Jacquie Baker, Kurt Kimpinski
BACKGROUND: In evaluating autonomic dysfunction, the autonomic reflex screen (ARS) is an established set of standardized tests to evaluate the presence and severity of autonomic dysfunction. Our laboratory previously reported normative data on 121 healthy individuals; however, the sample size in older individuals was reduced compared to other age groups. Therefore, the objective of the current study was to provide updated normative values representative of young, middle aged and older individuals from Southwestern Ontario...
December 5, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/30516676/18f-fdg-pet-and-bone-scintigraphy-of-epithelioid-hemangioendothelioma
#11
Marc-Antoine Hubaut, Alice Jaillard, Capucine Eloy, Gregory Petyt
We report the case of a 31-year-old woman with left foot bones located epithelioid hemangioendothelioma. It is a rare type of vascular tumor, locally aggressive with metastatic potential. It was revealed by a chronic isolated left foot pain. Conventional imaging showed multiple osteolytic lesions of the bones, appearing aggressive. Both bone scintigraphy and F-FDG PET showed an increased uptake of these lesions and confirmed the limited extent to distal extremity of the left lower limb. Final diagnosis was given on a surgical biopsy...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516674/unusual-focal-muscle-fdg-activity-related-to-altered-biomechanics
#12
Eleanor Gillis, Zhe Wen, Hongming Zhuang
A 20 year old man suffered severe right knee pain, especially when his right foot touched ground. The MRI findings suggested periosteal osteosarcoma, which led to a staging FDG PET/CT. The images showed not only a hypermetabolic right knee lesion but also focally elevated activity in select muscles, which was attributed to altered biomechanics. The resected lesion was pathologically proven as periosteal chondrosarcoma instead of periosteal osteosarcoma. In a follow-up period of 4 years after the surgery, there was no recurrent disease, nor any abnormality in the muscles which showed focal FDG activity on the initial FDG PET/CT...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516624/functional-outcomes-following-treatment-for-clubfoot-ten-year-follow-up
#13
Kelly A Jeans, Lori A Karol, Ashley L Erdman, Wilshaw R Stevens
BACKGROUND: The purpose of this study was to assess function, at the age of 10 years, of children initially treated nonoperatively for clubfoot with either the Ponseti or French physiotherapy program and to compare outcomes in feet that had undergone only nonoperative treatment with those that required subsequent surgery. METHODS: Gait analysis, isokinetic ankle strength, parent-reported outcomes, and daily step activity data were collected when patients who had been treated for idiopathic clubfoot reached the age of 10 years...
December 5, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/30516623/outcomes-of-the-ponseti-method-for-untreated-clubfeet-in-nepalese-patients-seen-between-the-ages-of-one-and-five-years-and-followed-for-at-least-10-years
#14
Bibek Banskota, Prakash Yadav, Tarun Rajbhandari, O P Shrestha, Divya Talwar, Ashok Banskota, David A Spiegel
BACKGROUND: To our knowledge, there are no reports of the Ponseti method initiated after walking age and with >10 years of follow-up. Our goal was to report the clinical findings and patient-reported outcomes for children with a previously untreated idiopathic clubfoot who were seen when they were between 1 and 5 years old, were treated with the Ponseti method, and had a minimum follow-up of 10 years. METHODS: A retrospective review of medical records was supplemented by a follow-up evaluation of physical findings (alignment and range of motion) and patient-reported outcomes using the Oxford Ankle Foot Questionnaire for Children (OxAFQ-C)...
December 5, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/30516182/a-rolling-circle-amplification-assisted-dna-walker-triggered-by-multiple-dnazyme-cores-for-highly-sensitive-electrochemical-biosensing
#15
Sina Wang, Yuhang Ji, Haomin Fu, Huangxian Ju, Jianping Lei
DNA walkers from monopodial to multipedal types have usually one cleavage site to power the walking system along with the track. Herein, a multipedal DNA walker (m-DNA walker) with multiple DNAzyme cores was constructed with the assistance of rolling circle amplification (RCA) for highly sensitive electrochemical biosensing. Firstly, a three-component DNA complex as a swing strand was prepared by integrating a padlock, an RCA primer and a block DNA as a recognition element in the DNA walker system. After ferrocene-labeled track DNA (trDNA) and capture DNA were fixed on a gold electrode, the three-component DNA complex was imported onto the electrode as a swing arm to form a m-DNA walker...
December 5, 2018: Analyst
https://www.readbyqxmd.com/read/30515957/risk-factors-for-mortality-in-patients-with-diabetic-foot-infections-a-prospective-cohort-study
#16
Sarah Alexandra Lynar, Claire Helen Robinson, Craig Steven Boutlis, Robert James Commons
BACKGROUND: An increasing prevalence of diabetes mellitus has led to a high risk of diabetic foot infections (DFI) and associated morbidity. However, little is known about the relationship between DFI and mortality. AIMS: To investigate the risk of mortality and associated factors in patients with DFI in an Australian context. METHODS: A prospective cohort study of inpatients with DFI between May 2012 and October 2016, at Royal Darwin Hospital, a tertiary referral hospital for the Top End of the Northern Territory...
December 4, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/30515655/deep-cutaneous-neoscytalidium-dimidiatum-infection-successful-outcome-with-amphotericin-b-therapy
#17
Shih-Jyun Yang, Chau-Yee Ng, Ting-Shu Wu, Po-Yen Huang, Yen-Mu Wu, Pei-Lun Sun
Phaeohyphomycosis is a term used to describe a heterogenous group of cutaneous and systemic mycotic infections caused by melanized fungi. Many fungi have been reported as pathogens of this disease. The disease spectrum ranges from superficial cutaneous infections, deep cutaneous infections, to systemic infections with internal organ involvement. We report two cases of deep cutaneous phaeohyphomycosis on the foot clinically presenting as cellulitis with abscess formation. The pathogens were isolated from the lesion and both were identified as Neoscytalidium dimidiatum by their colony morphology, microscopic features, and sequences of internal transcribed spacers of ribosomal DNA...
December 5, 2018: Mycopathologia
https://www.readbyqxmd.com/read/30515249/musculoskeletal-pain-and-symptoms-in-pregnancy-a-descriptive-study
#18
Serdar Kesikburun, Ümüt Güzelküçük, Ulaş Fidan, Yasin Demir, Ali Ergün, Arif Kenan Tan
Background: Pregnancy-induced hormonal and physiologic changes increase the risk of musculoskeletal problems in pregnancy. The purpose of this report is to provide a comprehensive look at the musculoskeletal pain and symptoms experienced during pregnancy. Methods: A total of 184 women (mean age 30.9 ± 5.0 years) who gave birth in the obstetrics clinic of a tertiary hospital were included in the study. The participants who had given birth at 37-42 weeks of pregnancy (term pregnancy) and aged over 18 years were selected for participation...
December 2018: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/30514835/3d-organoid-derived-human-glomeruli-for-personalised-podocyte-disease-modelling-and-drug-screening
#19
Lorna J Hale, Sara E Howden, Belinda Phipson, Andrew Lonsdale, Pei X Er, Irene Ghobrial, Salman Hosawi, Sean Wilson, Kynan T Lawlor, Shahnaz Khan, Alicia Oshlack, Catherine Quinlan, Rachel Lennon, Melissa H Little
The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming interdigitating foot processes with intervening slit diaphragms, disruption in which results in proteinuria. Studies into human podocytopathies to date have employed primary or immortalised podocyte cell lines cultured in 2D. Here we compare 3D human glomeruli sieved from induced pluripotent stem cell-derived kidney organoids with conditionally immortalised human podocyte cell lines, revealing improved podocyte-specific gene expression, maintenance in vitro of polarised protein localisation and an improved glomerular basement membrane matrisome compared to 2D cultures...
December 4, 2018: Nature Communications
https://www.readbyqxmd.com/read/30514731/adherence-to-guidelines-in-management-of-symptoms-suggestive-of-heart-failure-in-primary-care
#20
Benedict Hayhoe, Dani Kim, Paul P Aylin, F Azeem Majeed, Martin R Cowie, Alex Bottle
OBJECTIVE: Clinical guidelines on heart failure (HF) suggest timings for investigation and referral in primary care. We calculated the time for patients to achieve key elements in the recommended pathway to diagnosis of HF. METHODS: In this observational study, we used linked primary and secondary care data (Clinical Practice Research Datalink, a database of anonymised electronic records from UK general practices) between 2010 and 2013. Records were examined for presenting symptoms (breathlessness, fatigue, ankle swelling) and key elements of the National Institute for Health and Care Excellence-recommended pathway to diagnosis (serum natriuretic peptide (NP) test, echocardiography, specialist referral)...
December 4, 2018: Heart: Official Journal of the British Cardiac Society
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