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https://www.readbyqxmd.com/read/30114658/pharmacogenetic-analyses-of-2183-patients-with-advanced-colorectal-cancer-potential-role-for-common-dihydropyrimidine-dehydrogenase-variants-in-toxicity-to-chemotherapy
#1
Ayman Madi, David Fisher, Timothy S Maughan, James P Colley, Angela M Meade, Julie Maynard, Vikki Humphreys, Harpreet Wasan, Richard A Adams, Shelley Idziaszczyk, Rebecca Harris, Richard S Kaplan, Jeremy P Cheadle
BACKGROUND: Inherited genetic variants may influence response to, and side-effects from, chemotherapy. We sought to generate a comprehensive inherited pharmacogenetic profile for oxaliplatin and 5FU/capecitabine therapy in advanced colorectal cancer (aCRC). METHODS: We analysed more than 200 potentially functional, common, inherited variants in genes within the 5FU, capecitabine, oxaliplatin and DNA repair pathways, together with four rare dihydropyrimidine dehydrogenase (DPYD) variants, in 2183 aCRC patients treated with oxaliplatin-fluoropyrimidine chemotherapy with, or without, cetuximab (from MRC COIN and COIN-B trials)...
August 13, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/30114517/therapeutic-effects-of-caesalpinia-minax-hance-on-complete-freund-s-adjuvant-cfa-induced-arthritis-and-the-anti-inflammatory-activity-of-cassane-diterpenes-as-main-active-components
#2
Ziwei Tong, Li Cheng, Jizhou Song, Miao Wang, Jiuzhi Yuan, Xianzhe Li, Huiyuan Gao, Zhaohua Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Seeds of Caesalpinia minax Hance called 'Ku-Shi-Lian' (KSL) in China have been used as Zhuang or Dai folk medicines for treatment of common cold, fever, rheumatoid arthritis and dysentery for hundred years. AIM OF THE STUDY: This study aimed to investigate therapeutic efficacy of KSL extract using complete Freund's adjuvant (CFA) induced arthritis in a rat model and the anti-inflammatory activity of cassane diterpenes as the main active material basis of this herb...
August 13, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30114516/protective-effects-of-paederia-scandens-extract-on-rheumatoid-arthritis-mouse-model-by-modulating-gut-microbiota
#3
Man Xiao, Xiaopeng Fu, Yali Ni, Jifeng Chen, Shaoqing Jian, Liankai Wang, Li Li, Guankui Du
ETHNOPHARMACOLOGICAL RELEVANCE: Paederia scandens (Lour.) Merr. (P. scandens) has been traditionally used to treat the pain of rheumatism. AIM OF THE STUDY: The purpose of this study was to investigate the possible influences of P. scandens on the progression of rheumatoid arthritis (RA), inflammatory responses and gut bacterial communities in RA mouse model. MATERIALS AND METHODS: collagen-induced arthritis (CIA) mice were orally administered with P...
August 13, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30114498/should-the-histological-examination-be-used-in-the-diagnosis-of-aneurysms-of-the-dorsalis-pedis-artery-case-report-and-review-of-the-literature
#4
Tomasz Grzela, Radosław Piotrowicz, Krzysztof Leksowski
Aneurysms of the dorsalis pedis artery are rare, and they are not commonly examined histologically. In general, pseudoaneurysms are thought to be more common than true aneurysms of the dorsalis pedis artery. We present a patient with a true aneurysm of the dorsalis pedis artery, which was initially diagnosed as a pseudoaneurysm that had developed due to a blunt trauma of the ankle. However, the intraoperative appearance and histological examination both confirmed a true aneurysm. Our experiences seem to confirm, that postoperative histological examination is needed to distinguish pseudoaneurysms from true aneurysm of the dorsalis pedis artery...
August 13, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30114427/influence-of-debranching-and-retrogradation-time-on-behavior-changes-of-amorphophallus-paeoniifolius-nanostarch
#5
M Suriya, Chagam Koteswara Reddy, Sundaramoorthy Haripriya, N Harsha
In this study, Amorphophallus paeoniifolius (elephant foot yam) starch nanoparticles (SNPs) were produced using a native facile and green procedure integrated with debranching and recrystallization. SNPs were produced through debranching with pullulanase followed by 12- and 24-h retrogradation time. Transmission electron microscopy, dynamic light scattering, infrared spectroscopy, differential scanning colorimetry, and x-ray diffraction were utilized to illustrate the in-vitro digestibility, molecular structure, morphology, and behavior changes of SNPs...
August 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30114227/generation-and-characterisation-of-recombinant-fmdv-antibodies-applications-for-advancing-diagnostic-and-laboratory-assays
#6
Gareth Shimmon, Abhay Kotecha, Jingshan Ren, Amin S Asfor, Joseph Newman, Stephen Berryman, Eleanor M Cottam, Sarah Gold, Toby J Tuthill, Donald P King, Emiliana Brocchi, Andrew M Q King, Ray Owens, Elizabeth E Fry, David I Stuart, Alison Burman, Terry Jackson
Foot-and-mouth disease (FMD) affects economically important livestock and is one of the most contagious viral diseases. The most commonly used FMD diagnostic assay is a sandwich ELISA. However, the main disadvantage of this ELISA is that it requires anti-FMD virus (FMDV) serotype-specific antibodies raised in small animals. This problem can be, in part, overcome by using anti-FMDV monoclonal antibodies (MAbs) as detecting reagents. However, the long-term use of MAbs may be problematic and they may need to be replaced...
2018: PloS One
https://www.readbyqxmd.com/read/30113912/a-minimally-invasive-sinus-tarsi-approach-with-percutaneous-k-wires-fixation-for-intra-articular-calcaneal-fractures-in-children
#7
Lei Tong, Mingjing Li, Fan Li, Jian Xu, Tao Hu
The aim of this study was to analyze the management of displaced intra-articular calcaneal fractures in children at our pediatric orthopedic and to determine the results following open reduction via minimally invasive sinus tarsi approach and fixation with Kirschner wires (K-wires). Overall, 25 available cases of calcaneal fractures in children with mean age of 9.8 years were treated by open reduction from January 2010 to December 2015. All patients were followed up from 12 to 30 months (mean: 19 months). Clinical functional outcomes were graded using the American Orthopedic Foot and Ankle Society hindfoot scores...
August 15, 2018: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/30113876/low-efficacy-using-the-256-hz-tuning-fork-when-evaluating-the-influence-of-somatosensation-in-balance-control-for-relatively-healthy-elderly
#8
Anna Hafström
BACKGROUND: Diminished foot somatosensation contributes to balance deficits and increased fall risk. However, it remains unclear if the 256-Hz tuning fork is adequate to measure, in the outpatient clinical setting, somatosensation in relatively healthy elderly. AIMS/OBJECTIVES: To evaluate the performance of the 256-Hz tuning fork compared to other measures of somatosensation and balance. MATERIAL AND METHODS: Thirty-six subjects (mean 69...
August 16, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/30113548/adherence-to-activity-monitoring-devices-or-smartphone-applications-for-improving-physical-activity-in-adults-with-cardiovascular-disease-a-systematic-review-protocol
#9
Constance Kourbelis, Julie Franzon, Jonathon W Foote, Alex Brown, Mark Daniel, Neil T Coffee, Peter Newman, Anand Ganesan, Stephen Nicholls, Robyn A Clark
The question of this review is: what is the adherence to the use of activity monitoring devices or applications to improve physical activity in adults with cardiovascular disease?Specifically, the review objectives are.
August 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/30113521/walking-in-minimalist-shoes-is-effective-for-strengthening-foot-muscles
#10
Sarah T Ridge, Mark T Olsen, Dustin A Bruening, Kevin Jurgensmeier, David Griffin, Irene S Davis, A Wayne Johnson
INTRODUCTION: Weakness of foot muscles may contribute to a variety of loading related injuries. Supportive footwear may contribute to intrinsic foot muscle weakness by reducing the muscles' role in locomotion (e.g. absorbing forces and controlling motion). Increased stimulus to the foot muscles can be provided through a variety of mechanisms, including minimalist footwear and directed exercise. PURPOSE: To determine the effect of walking in minimalist footwear or performing foot strengthening exercises on foot muscle size and strength...
August 15, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/30113466/effect-of-reducing-assistance-during-robot-assisted-gait-training-on-step-length-asymmetry-in-patients-with-hemiplegic-stroke-a-randomized-controlled-pilot-trial
#11
Jin Seok Seo, Hee Seung Yang, Suk Jung, Chang Soon Kang, Sunghun Jang, Dae Hyun Kim
BACKGROUND: An assist-as-needed robot-assisted gait training protocol was recently developed. It allows active movement during training, but its exact criteria remain unknown. Asymmetric step length is a common abnormal gait pattern in hemiplegic stroke patients. We compared the effects of assist-as-needed robot-assisted gait training on the unaffected and affected limbs of hemiplegic stroke patients. METHOD: Twenty-four chronic stroke patients with asymmetric step lengths were randomly assigned to 1 of 2 groups...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30113445/validity-of-tinel-sign-and-prevalence-of-tibial-nerve-entrapment-at-the-tarsal-tunnel-in-both-diabetic-and-non-diabetic-subjects-a-cross-sectional-study
#12
Willem D Rinkel, Manuel Castro Cabezas, Johan W van Neck, Erwin Birnie, Steven E R Hovius, J Henk Coert
BACKGROUND: Nerve entrapments like carpal tunnel syndrome are more prevalent in patients with diabetes, especially in those with diabetic polyneuropathy. Our study aim was to investigate the validity of the Tinel sign in diagnosing tibial neuropathy and determine the prevalence of tibial nerve entrapment in both a diabetic and non-diabetic population. METHODS: 240 non-neuropathic subjects with diabetes and 176 diabetic subjects with neuropathy participating in the prospective Rotterdam Diabetic Foot Study and 196 reference subjects without diabetes and without neuropathy complaints were evaluated...
August 11, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/30113145/cardio-ankle-vascular-index-as-a-surrogate-marker-of-early-atherosclerotic-cardiovascular-disease-in-koreans-with-type-2-diabetes-mellitus
#13
So Young Park, Sang Ook Chin, Sang Youl Rhee, Seungjoon Oh, Jeong Taek Woo, Sung Woon Kim, Suk Chon
BACKGROUND: Carotid artery intima medial thickness (IMT), brachial-ankle pulse wave velocity (baPWV), and ankle-brachial index (ABI) are commonly used surrogate markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus (T2DM). The cardio-ankle vascular index (CAVI) is a complement to the baPWV, which is affected by blood pressure. However, it is unclear which marker is the most sensitive predictor of atherosclerotic cardiovascular disease (ASCVD). METHODS: This was a retrospective non-interventional study that enrolled 219 patients with T2DM...
July 27, 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/30113131/macroeconomic-impact-of-foot-and-mouth-disease-vaccination-strategies-for-an-outbreak-in-the-midwestern-united-states-a-computable-general-equilibrium
#14
Maryfrances Miller, Lirong Liu, Steven Shwiff, Stephanie Shwiff
The impacts of alternative responses to a hypothetical foot and mouth disease (FMD) outbreak occurring in the Midwestern United States are estimated using the Regional Economic Modeling Incorporated Policy Insight + (REMI) computable general equilibrium model, with particular attention paid to the employment impact estimates. The impact on employment and GDP is estimated using forecasts of a 10-year period with disease outbreak duration up to 2 years. Fifteen different vaccination protocols are compared to a disease control protocol that relies on animal depopulation with no vaccination...
August 16, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/30112690/prognostic-impact-of-the-ankle-brachial-index-on-the-development-of-micro-and-macrovascular-complications-in-individuals-with-type-2-diabetes-the-rio-de-janeiro-type-2-diabetes-cohort-study
#15
Claudia R L Cardoso, Juliana V Melo, Guilherme C Salles, Nathalie C Leite, Gil F Salles
AIMS/HYPOTHESIS: The prognostic importance of the ankle-brachial index (ABI) in individuals with diabetes is controversial. We aimed to evaluate the relationship between the ABI and the occurrence of micro- and macrovascular complications in individuals with type 2 diabetes. METHODS: The ABI was measured at baseline in 668 individuals with type 2 diabetes, and the individuals were followed-up for a median of 10 years. Multivariate Cox analysis was used to examine associations between the ABI and the occurrence of microvascular (retinopathy, microalbuminuria, renal function deterioration and peripheral neuropathy) and macrovascular (total cardiovascular events, major adverse cardiovascular events [MACE] and cardiovascular mortality) complications, and all-cause mortality...
August 15, 2018: Diabetologia
https://www.readbyqxmd.com/read/30112613/comparison-of-long-pulsed-nd-yag-laser-with-cryotherapy-in-treatment-of-acral-warts
#16
M Gheisari, B Iranmanesh, N Najar Nobari, M Amani
Acral warts are considered as prevalent reasons for dermatologic consultations and remain an important continuing challenge until now because there is no consensus about optimal therapeutic modality. This study investigated the efficacy of long-pulsed Nd: YAG laser therapy and cryotherapy in treatment of acral warts. Patients who underwent treatment with cryotherapy or long-pulsed Nd: YAG laser therapy for symmetrical and bilateral warts on the extremities (hand and foot) that is confirmed by an expert dermatologist from May 2016 until March 2018 were assessed for enrollment in our study...
August 15, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/30112582/updates-on-diabetic-foot-and-charcot-osteopathic-arthropathy
#17
REVIEW
Brian M Schmidt, Crystal M Holmes
PURPOSE OF REVIEW: Diabetes mellitus affects approximately 30.8 million people currently living in the USA. Chronic diabetes complications, including diabetic foot complications, remain prevalent and challenging to treat. We review clinical diagnosis and challenges providers may encounter when managing diabetic foot ulcers and Charcot neuroarthropathy. RECENT FINDINGS: Mechanisms controlling these diseases are being elucidated and not fully understood. Offloading is paramount to heal and manage diabetic foot ulcers and Charcot neuroarthropathy...
August 15, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30112353/genetic-identification-and-serological-evaluation-of-commercial-inactivated-foot-and-mouth-disease-virus-vaccine-in-pigs
#18
Sang H Je, Taeyong Kwon, Sung J Yoo, Dong-Uk Lee, Sang Won Seo, Jeong J Byun, Jeong Y Shin, Young S Lyoo
Vaccination is considered a frequently used tool to prevent and control foot-and-mouth disease (FMD). However, the effectiveness of conventional FMD virus (FMDV) vaccines in pigs has been controversial because the massive prophylactic vaccination could not elicit proper immune response nor prevent the broad spread of FMD outbreak, mainly in pig farms, in South Korea during outbreaks of 2014. In addition, there has been little information on the efficacy of inactivated, high potency, multivalent, oil-based FMDV vaccine in pigs, because an evaluation of FMDV vaccines had been mainly carried out using cattle...
July 2018: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/30112132/atraumatic-insufficiency-fractures-of-the-tarsal-bones-an-unusual-cause-of-recurrent-heel-pain-in-a-patient-with-rheumatoid-arthritis-a-case-report
#19
A Rajeev
The incidence of insufficiency fractures is approximately 1% in rheumatoid arthritis patients. The predisposing factors are chronic inflammation, skeletal deformities, biomechanical stresses and osteoporosis. The medications used in the treatment of rheumatoid arthritis such as Glucocorticosteroids and Methotrexate also contribute to the development of osteoporosis and insufficiency fractures. A 68-year old lady who was suffering from rheumatoid arthritis and on long term Methotrexate was seen in the outpatient clinic with recurrent episodes of heel pain...
July 2018: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/30112129/bilateral-talus-and-navicular-fractures-accompanied-with-unilateral-calcaneal-fracture-a-case-report
#20
G Bulut, I Colak, G Mik, Z Kilic, Z Tasdemir
An 18-year old male patient, with a history of paragliding accident, sustaining a coronal shear fracture of the body of the talus, an anterior process fracture of the calcaneus extending to the calcaneocuboid joint and a nondisplaced navicular body fracture at the right foot and a displaced fracture of the navicular body accompanied with posteromedial process fracture of the talus at the left side was referred to our emergency clinic. For the right foot, the coronal plane fracture of the talar body was anatomically reduced and fixed with screws...
July 2018: Malaysian Orthopaedic Journal
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